Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	keratohyalin granule	FLG FLG2	1.73e-05	5	28	2	GO:0036457
MousePheno	increased circulating insulin level	TCF20 ATXN2 HDC ARNT2 BAD	5.12e-05	283	21	5	MP:0002079
Domain	Filaggrin	FLG FLG2	2.49e-06	2	30	2	IPR003303
Domain	S100_CABP	FLG FLG2	8.54e-04	27	30	2	PS00303
Domain	S_100	FLG FLG2	8.54e-04	27	30	2	PF01023
Domain	S100_Ca-bd_sub	FLG FLG2	9.19e-04	28	30	2	IPR013787
Domain	S100/CaBP-9k_CS	FLG FLG2	9.19e-04	28	30	2	IPR001751
Domain	S_100	FLG FLG2	9.19e-04	28	30	2	SM01394
Domain	PHD	TCF20 BAZ1A	8.96e-03	89	30	2	SM00249
Domain	Znf_PHD	TCF20 BAZ1A	9.35e-03	91	30	2	IPR001965
Domain	ZF_PHD_2	TCF20 BAZ1A	1.02e-02	95	30	2	PS50016
Domain	ZF_PHD_1	TCF20 BAZ1A	1.04e-02	96	30	2	PS01359
Domain	HLH	USF3 ARNT2	1.37e-02	111	30	2	PF00010
Domain	HLH	USF3 ARNT2	1.49e-02	116	30	2	SM00353
Domain	BHLH	USF3 ARNT2	1.51e-02	117	30	2	PS50888
Domain	bHLH_dom	USF3 ARNT2	1.53e-02	118	30	2	IPR011598
Pubmed	Expression of filaggrin-2 protein in the epidermis of human skin diseases: a comparative analysis with filaggrin.	FLG FLG2	7.69e-07	2	31	2	24813994
Pubmed	Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.	FLG FLG2	2.31e-06	3	31	2	23403047
Pubmed	Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.	FLG FLG2	2.31e-06	3	31	2	32437351
Pubmed	GATA3 regulates FLG and FLG2 expression in human primary keratinocytes.	FLG FLG2	2.31e-06	3	31	2	28928464
Pubmed	Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype.	FLG FLG2	1.15e-05	6	31	2	27304082
Pubmed	Interaction network of human early embryonic transcription factors.	BCL9L EPC2 TCF20 FLG2 BAZ1A	1.39e-05	351	31	5	38297188
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CDK8 EP400P1 FAM117B USF3 SMG7 ATXN2 GOLM2 BAD	3.62e-05	1489	31	8	28611215
Pubmed	TRIM25 and DEAD-Box RNA Helicase DDX3X Cooperate to Regulate RIG-I-Mediated Antiviral Immunity.	FLG FLG2 SBSN	7.39e-05	91	31	3	34445801
Pubmed	Isoform-specific GSK3A activity is negatively correlated with human sperm motility.	SMG7 GOLM2 SBSN	7.63e-05	92	31	3	30824926
Pubmed	TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.	FLG FLG2 SBSN	1.56e-04	117	31	3	36898370
Pubmed	Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.	FLG FLG2	1.60e-04	21	31	2	19601998
Pubmed	Human transcription factor protein interaction networks.	FLG BCL9L EPC2 TCF20 SMG7 FLG2 ATXN2	2.15e-04	1429	31	7	35140242
Pubmed	NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer.	FLG2 ATXN2 SBSN	3.56e-04	155	31	3	33838681
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ZCCHC14 HOXC8 TCF20 BAZ1A ARNT2	3.80e-04	709	31	5	22988430
Pubmed	Proteomic characterization of the human sperm nucleus.	SEMG2 FLG FLG2 RAB2A	5.96e-04	438	31	4	21630459
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	BCL9L TCF20 SMG7 ATXN2	6.99e-04	457	31	4	32344865
Pubmed	A human MAP kinase interactome.	USF3 TCF20 CPLANE1 BAD	8.79e-04	486	31	4	20936779
Interaction	PI4KAP1 interactions	FLG FLG2 SBSN	1.70e-05	35	29	3	int:PI4KAP1
Interaction	PRSS16 interactions	FLG FLG2 SBSN	3.41e-05	44	29	3	int:PRSS16
GeneFamily	EF-hand domain containing\|S100 fused type protein family	FLG FLG2	1.17e-05	7	14	2	1350
GeneFamily	EF-hand domain containing	FLG FLG2	1.21e-02	219	14	2	863
Coexpression	TABULA_MURIS_SENIS_MARROW_CD4_POSITIVE_ALPHA_BETA_T_CELL_AGEING	BCL9L ATXN2 BAZ1A	1.67e-05	42	31	3	MM3791
Disease	asthma	THSD4 SCUBE3 SEMG2 FLG ATXN2	1.03e-03	751	31	5	MONDO_0004979
Disease	sarcoidosis	FAM117B ATXN2	2.07e-03	64	31	2	MONDO_0019338
Disease	wheezing	USF3 AMMECR1L	2.13e-03	65	31	2	EFO_0009715
Disease	allergic disease, age at onset	FLG ATXN2	2.54e-03	71	31	2	EFO_0004847, MONDO_0005271
Disease	leucine measurement	C16orf82 ATXN2	2.68e-03	73	31	2	EFO_0009770
Disease	pulmonary function measurement	THSD4 EP400P1	2.98e-03	77	31	2	EFO_0003892
Disease	monocyte measurement	FAM117B ATXN2	3.37e-03	82	31	2	EFO_0803547
Disease	systemic scleroderma	FLG2 RAB2A	3.61e-03	85	31	2	EFO_0000717
Disease	age of onset of childhood onset asthma	SCUBE3 ATXN2	4.22e-03	92	31	2	OBA_2001015
Disease	childhood onset asthma	SCUBE3 FLG ATXN2	5.11e-03	334	31	3	MONDO_0005405
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	TCF20 ATXN2	5.25e-03	103	31	2	EFO_0008595, EFO_0020944
Disease	low density lipoprotein cholesterol measurement, phospholipid measurement	FAM117B ATXN2	7.06e-03	120	31	2	EFO_0004611, EFO_0004639
Disease	autoimmune thyroid disease	RAB2A ATXN2	7.76e-03	126	31	2	EFO_0006812
Disease	celiac disease	SMG7 ATXN2	7.76e-03	126	31	2	EFO_0001060

Protein segments in the cluster

Peptide	Gene	Start	Entry
GHNNINGVVQPSGTS	EPC2	661	Q52LR7
SGPLQNHQHVDSSSG	AMMECR1L	46	Q6DCA0
QQEQPTSSSHHGGAG	BAD	51	Q92934
VSGHGQDGPHQQSHQ	FLG	1086	P20930
DTQSVSAHGQAGPHQ	FLG	1406	P20930
TQSVSAHGQAGPHQQ	FLG	1731	P20930
GPHQQSHQESTRGQS	FLG	1741	P20930
QSVSAHGQAGPHQQS	FLG	2381	P20930
DTQSVSGHGQAGPHQ	FLG	3351	P20930
SGHGQAGPHQQSHQE	FLG	3356	P20930
TQSVSAHGQAGPHQQ	FLG	3676	P20930
GQDQNPNHHLSGSCT	CDHR4	521	A6H8M9
PPSHQNGFANGHVNS	BAZ1A	141	Q9NRL2
GQQSGEQHSHQQPGQ	ARNT2	666	Q9HBZ2
HAATNATHAGNQGGQ	RAB2A	191	P61019
HHPSSQGGGVLQSTV	HDC	136	P19113
QHGSNSGQTSGFGQH	FLG2	1091	Q5D862
GSHRPQSQEQTHGQA	FLG2	1436	Q5D862
QSQEQTHGQAGSQHG	FLG2	1441	Q5D862
GHTHGQAGSQHGQSE	FLG2	1671	Q5D862
EHGHPSHGQTIQTGS	FLG2	1931	Q5D862
RHGQSGHGQSTQTGS	FLG2	2156	Q5D862
HSGHIQGQAGSQQRQ	FLG2	2271	Q5D862
TNGSQPGAPHNSTHT	FAM174C	46	Q9BVV8
ATPTGQQQSQHGGSH	ATXN2	1151	Q99700
HTQSGGTIHHLGPQS	EP400P1	216	Q6ZTU2
HGQESHNSGNRSDGP	GPR87	16	Q9BY21
GQNSTGNVQNVPHGS	CPLANE1	2146	Q9H799
QQQQQHGSPTRSGGG	FAM117B	46	Q6P1L5
NHGKTGNGGAQSQHQ	BCL9L	46	Q86UU0
HHGTSGISNSGYQQN	HOXC8	61	P31273
QQGNNHTNGTGHPGN	CDK8	376	P49336
HTNGTGHPGNQDSSH	CDK8	381	P49336
PARAGHNGNSTNSNH	SCUBE3	456	Q8IX30
NGNHQSGSSSHQGGA	SBSN	546	Q6UWP8
DSHINHNGNPGTSKQ	GOLM2	301	Q6P4E1
ATQQSFHLHGTGQPN	RUSC2	126	Q8N2Y8
HSGTPQNNGNVAHFD	TMC3	761	Q7Z5M5
HSPAGNQVQAGKQSH	SMG7	701	Q92540
KGGQAHHGTQNPSQD	SEMG2	131	Q02383
HHGTQNPSQDQGNSP	SEMG2	136	Q02383
QQGSGVSSEHVSGHN	USF3	1611	Q68DE3
HGNQQSYPQEVHGSS	TCF20	11	Q9UGU0
AGIPSSQSGAQHHGQ	ZCCHC14	236	Q8WYQ9
SQSGAQHHGQHPAGS	ZCCHC14	241	Q8WYQ9
HSPETSNNHGVGTHG	THSD4	261	Q6ZMP0
SNNHGVGTHGATQSF	THSD4	266	Q6ZMP0
SPQRGHSQHSEASQG	C16orf82	46	Q7Z2V1