Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	triplex DNA binding	DDX12P DDX11	9.94e-05	4	82	2	GO:0045142
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF567 ZNF878 THRB MAFA INSM1 ZNF778 INSM2 ZBTB26 ZNF226 ZNF333 ZNF774 ZNF835 ZNF441 SMAD4 ZNF513 HOXA2	2.53e-04	1459	82	16	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF567 THRB MAFA INSM1 ZNF778 INSM2 ZBTB26 ZNF226 ZNF333 ZNF774 ZNF835 SMAD4 ZNF513 HOXA2	5.03e-04	1244	82	14	GO:0000978
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	HOXB2 ZNF878 THRB MAFA INSM1 ZNF778 INSM2 ZBTB26 ZNF226 ZNF333 ZNF774 ZNF441 SMAD4 ZNF513 HOXA2	5.68e-04	1412	82	15	GO:0000981
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF567 THRB MAFA INSM1 ZNF778 INSM2 ZBTB26 ZNF226 ZNF333 ZNF774 ZNF835 SMAD4 ZNF513 HOXA2	6.23e-04	1271	82	14	GO:0000987
GeneOntologyBiologicalProcess	snoRNA splicing	RNF113B RNF113A	1.56e-05	2	82	2	GO:0034247
Domain	PKC	PRKCI PRKCZ	1.90e-05	2	82	2	IPR012233
Domain	-	ZNF567 ZNF878 INSM1 ZNF778 INSM2 ZBTB26 ZNF226 ZNF333 ZNF774 ZNF835 ZNF441 ZNF513	3.90e-05	679	82	12	3.30.160.60
Domain	zf-C2H2	ZNF567 ZNF878 INSM1 ZNF778 INSM2 ZBTB26 ZNF226 ZNF333 ZNF774 ZNF835 ZNF441 ZNF513	4.75e-05	693	82	12	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF567 ZNF878 INSM1 ZNF778 INSM2 ZBTB26 ZNF226 ZNF333 ZNF774 ZNF835 ZNF441 ZNF513	4.81e-05	694	82	12	IPR013087
Domain	REJ	PKD1L1 PKDREJ	1.14e-04	4	82	2	PS51111
Domain	REJ_dom	PKD1L1 PKDREJ	1.14e-04	4	82	2	IPR014010
Domain	ZINC_FINGER_C2H2_2	ZNF567 ZNF878 INSM1 ZNF778 INSM2 ZBTB26 ZNF226 ZNF333 ZNF774 ZNF835 ZNF441 ZNF513	1.37e-04	775	82	12	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF567 ZNF878 INSM1 ZNF778 INSM2 ZBTB26 ZNF226 ZNF333 ZNF774 ZNF835 ZNF441 ZNF513	1.41e-04	777	82	12	PS00028
Domain	Znf_C2H2-like	ZNF567 ZNF878 INSM1 ZNF778 INSM2 ZBTB26 ZNF226 ZNF333 ZNF774 ZNF835 ZNF441 ZNF513	1.76e-04	796	82	12	IPR015880
Domain	KIND_dom	PTPN13 SPIRE1	1.89e-04	5	82	2	IPR011019
Domain	KIND	PTPN13 SPIRE1	1.89e-04	5	82	2	SM00750
Domain	KIND	PTPN13 SPIRE1	1.89e-04	5	82	2	PS51377
Domain	Znf_C2H2	ZNF567 ZNF878 INSM1 ZNF778 INSM2 ZBTB26 ZNF226 ZNF333 ZNF774 ZNF835 ZNF441 ZNF513	1.96e-04	805	82	12	IPR007087
Domain	ZnF_C2H2	ZNF567 ZNF878 INSM1 ZNF778 INSM2 ZBTB26 ZNF226 ZNF333 ZNF774 ZNF835 ZNF441 ZNF513	2.02e-04	808	82	12	SM00355
Domain	PKD/REJ-like	PKD1L1 PKDREJ	2.82e-04	6	82	2	IPR002859
Domain	REJ	PKD1L1 PKDREJ	2.82e-04	6	82	2	PF02010
Domain	GPS	PKD1L1 ADGRB3 PKDREJ	5.69e-04	37	82	3	IPR000203
Domain	-	RNF113B RNF113A PAN3	7.17e-04	40	82	3	4.10.1000.10
Domain	KRAB	ZNF567 ZNF878 ZNF778 ZNF226 ZNF333 ZNF774 ZNF441	9.94e-04	358	82	7	PS50805
Domain	PKD_channel	PKD1L1 PKDREJ	1.02e-03	11	82	2	PF08016
Domain	PKD1_2_channel	PKD1L1 PKDREJ	1.02e-03	11	82	2	IPR013122
Domain	ZnF_C3H1	RNF113B RNF113A PAN3	1.22e-03	48	82	3	SM00356
Domain	PB1	PRKCI PRKCZ	1.67e-03	14	82	2	SM00666
Domain	PB1	PRKCI PRKCZ	1.67e-03	14	82	2	PF00564
Domain	zf-H2C2_2	ZNF778 ZNF333	1.67e-03	14	82	2	PF13465
Domain	PB1	PRKCI PRKCZ	1.67e-03	14	82	2	PS51745
Domain	PB1_dom	PRKCI PRKCZ	1.67e-03	14	82	2	IPR000270
Domain	Znf_CCCH	RNF113B RNF113A PAN3	2.12e-03	58	82	3	IPR000571
Domain	ZF_C3H1	RNF113B RNF113A PAN3	2.12e-03	58	82	3	PS50103
Domain	LH2	PKD1L1 PKDREJ	2.78e-03	18	82	2	SM00308
Domain	HATPase_c	MLH3 BCKDK	2.78e-03	18	82	2	SM00387
Domain	HATPase_c	MLH3 BCKDK	3.10e-03	19	82	2	PF02518
Domain	-	MLH3 BCKDK	3.44e-03	20	82	2	3.30.565.10
Domain	PLAT	PKD1L1 PKDREJ	3.79e-03	21	82	2	PS50095
Domain	DAG/PE-bd	PRKCI PRKCZ	3.79e-03	21	82	2	IPR020454
Domain	-	PKD1L1 PKDREJ	3.79e-03	21	82	2	2.60.60.20
Domain	Homeobox_Antennapedia_CS	HOXB2 HOXA2	3.79e-03	21	82	2	IPR001827
Domain	PLAT	PKD1L1 PKDREJ	3.79e-03	21	82	2	PF01477
Domain	HATPase_C	MLH3 BCKDK	3.79e-03	21	82	2	IPR003594
Domain	PLAT/LH2_dom	PKD1L1 PKDREJ	3.79e-03	21	82	2	IPR001024
Domain	KRAB	ZNF567 ZNF878 ZNF778 ZNF226 ZNF333 ZNF441	4.91e-03	358	82	6	PF01352
Domain	ANTENNAPEDIA	HOXB2 HOXA2	4.94e-03	24	82	2	PS00032
Domain	WD40	WDR45 DCAF8L2 FBXW5 CFAP44 DMXL1	5.65e-03	259	82	5	PF00400
Domain	KRAB	ZNF567 ZNF878 ZNF778 ZNF226 ZNF333 ZNF441	5.67e-03	369	82	6	SM00349
Domain	KRAB	ZNF567 ZNF878 ZNF778 ZNF226 ZNF333 ZNF441	5.74e-03	370	82	6	IPR001909
Domain	WD40	WDR45 DCAF8L2 FBXW5 CFAP44 DMXL1	6.52e-03	268	82	5	SM00320
Pathway	WP_WNT_SIGNALING	CCND3 WNT5B PRKCI PRKCZ MAPK10	9.37e-06	61	66	5	MM15893
Pathway	WP_WNT_SIGNALING_AND_PLURIPOTENCY	CCND3 WNT5B PRKCI PRKCZ MAPK10	1.08e-04	101	66	5	M39387
Pathway	WP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY	CCND3 WNT5B PRKCI PRKCZ MAPK10	1.08e-04	101	66	5	MM15829
Pubmed	Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport.	PRKCI PRKCZ	5.76e-06	2	84	2	16644736
Pubmed	Expression of the atypical protein kinase C (aPKC) isoforms iota/lambda and zeta during mouse embryogenesis.	PRKCI PRKCZ	5.76e-06	2	84	2	16931174
Pubmed	Requirements for pseudosubstrate arginine residues during autoinhibition and phosphatidylinositol 3,4,5-(PO₄)₃-dependent activation of atypical PKC.	PRKCI PRKCZ	5.76e-06	2	84	2	25035426
Pubmed	Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells.	PRKCZ CXCL12	5.76e-06	2	84	2	15630457
Pubmed	Regulation of cell survival by atypical protein kinase C isozymes.	PRKCI PRKCZ	5.76e-06	2	84	2	12791393
Pubmed	Loss of SETD2 aggravates colorectal cancer progression caused by SMAD4 deletion through the RAS/ERK signalling pathway.	SETD2 SMAD4	5.76e-06	2	84	2	37962020
Pubmed	aPKCλ/ι and aPKCζ contribute to podocyte differentiation and glomerular maturation.	PRKCI PRKCZ	5.76e-06	2	84	2	23334392
Pubmed	Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation.	PRKCI PRKCZ	5.76e-06	2	84	2	21653884
Pubmed	Two novel atypical PKC inhibitors; ACPD and DNDA effectively mitigate cell proliferation and epithelial to mesenchymal transition of metastatic melanoma while inducing apoptosis.	PRKCI PRKCZ	5.76e-06	2	84	2	29048609
Pubmed	PKCλ/ι signaling promotes triple-negative breast cancer growth and metastasis.	PRKCI PRKCZ	5.76e-06	2	84	2	24786829
Pubmed	The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors.	PRKCI PRKCZ	5.76e-06	2	84	2	30610188
Pubmed	Atypical protein kinase C isoforms differentially regulate directional keratinocyte migration during wound healing.	PRKCI PRKCZ	5.76e-06	2	84	2	30660448
Pubmed	Functional comparison of protein domains within aPKCs involved in nucleocytoplasmic shuttling.	PRKCI PRKCZ	5.76e-06	2	84	2	23213435
Pubmed	Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene.	PTPN13 MAPK10	5.76e-06	2	84	2	12436199
Pubmed	Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion.	DDX12P DDX11	5.76e-06	2	84	2	32855419
Pubmed	Atypical protein kinase C activity is required for extracellular matrix degradation and invasion by Src-transformed cells.	PRKCI PRKCZ	5.76e-06	2	84	2	19492416
Pubmed	Ceramide regulates atypical PKCzeta/lambda-mediated cell polarity in primitive ectoderm cells. A novel function of sphingolipids in morphogenesis.	PRKCI PRKCZ	5.76e-06	2	84	2	17105725
Pubmed	Hox2 Genes Are Required for Tonotopic Map Precision and Sound Discrimination in the Mouse Auditory Brainstem.	HOXB2 HOXA2	5.76e-06	2	84	2	28052248
Pubmed	Localization of chi1-related helicase genes to human chromosome regions 12p11 and 12p13: similarity between parts of these genes and conserved human telomeric-associated DNA.	DDX12P DDX11	5.76e-06	2	84	2	8833153
Pubmed	Regulation of asymmetric division and CD8+ T lymphocyte fate specification by protein kinase Cζ and protein kinase Cλ/ι.	PRKCI PRKCZ	5.76e-06	2	84	2	25617472
Pubmed	Atypical PKC-zeta and PKC-iota mediate opposing effects on MCF-7 Na+/K+ATPase activity.	PRKCI PRKCZ	5.76e-06	2	84	2	15887250
Pubmed	Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1.	DDX12P DDX11	5.76e-06	2	84	2	9013641
Pubmed	Human placenta and trophoblasts simultaneously express three isoforms of atypical protein kinase-c.	PRKCI PRKCZ	5.76e-06	2	84	2	35124330
Pubmed	HIV envelope gp120 activates human arterial smooth muscle cells.	PRKCI PRKCZ MAPK10	6.06e-06	15	84	3	11504923
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	ZNF567 THRB CBFA2T2 BARD1 INSM2 ZNF226 EZH1 KDM4B SMAD4 ZNF513 HOXA2	8.56e-06	877	84	11	20211142
Pubmed	Solution structure of atypical protein kinase C PB1 domain and its mode of interaction with ZIP/p62 and MEK5.	PRKCI PRKCZ	1.73e-05	3	84	2	15143057
Pubmed	The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C.	PRKCI PRKCZ	1.73e-05	3	84	2	8797824
Pubmed	MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling.	PRKCI PRKCZ	1.73e-05	3	84	2	11158308
Pubmed	HIV-1-Tat potentiates CXCL12/stromal cell-derived factor 1-induced downregulation of membrane CXCR4 in T lymphocytes through protein kinase C zeta.	PRKCZ CXCL12	1.73e-05	3	84	2	18760839
Pubmed	The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis.	PRKCI PRKCZ	1.73e-05	3	84	2	19528321
Pubmed	Identification of Lmo1 as part of a Hox-dependent regulatory network for hindbrain patterning.	HOXB2 HOXA2	1.73e-05	3	84	2	17676642
Pubmed	Aberrant expression of the polarity complex atypical PKC and non-muscle myosin IIA in active and inactive inflammatory bowel disease.	PRKCI PRKCZ	1.73e-05	3	84	2	21667320
Pubmed	Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation.	PRKCI PRKCZ	1.73e-05	3	84	2	14570876
Pubmed	Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation.	DDX12P DDX11	1.73e-05	3	84	2	17611414
Pubmed	The chemokine SDF1 controls multiple steps of myogenesis through atypical PKCzeta.	PRKCZ CXCL12	1.73e-05	3	84	2	17971416
Pubmed	Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways.	PRKCI PRKCZ	1.73e-05	3	84	2	14734537
Pubmed	PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes.	PRKCI PRKCZ	1.73e-05	3	84	2	17588663
Pubmed	Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos.	PRKCI PRKCZ	1.73e-05	3	84	2	23791731
Pubmed	Control of MT1-MMP transport by atypical PKC during breast-cancer progression.	PRKCI PRKCZ	1.73e-05	3	84	2	24753582
Pubmed	Mammalian ChlR1 has a role in heterochromatin organization.	DDX12P DDX11	1.73e-05	3	84	2	21854770
Pubmed	Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina.	CCND3 PRKCI PRKCZ	2.32e-05	23	84	3	16267237
Pubmed	Atypical protein kinase C is essential for embryonic vascular development in mice.	PRKCI PRKCZ	3.45e-05	4	84	2	33547760
Pubmed	Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones.	PRKCI PRKCZ	3.45e-05	4	84	2	19549684
Pubmed	The diacylglycerol kinase α/atypical PKC/β1 integrin pathway in SDF-1α mammary carcinoma invasiveness.	PRKCI CXCL12	3.45e-05	4	84	2	24887021
Pubmed	Hydrogen sulfide and L-cysteine increase phosphatidylinositol 3,4,5-trisphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin homolog (PTEN) protein and activating phosphoinositide 3-kinase (PI3K)/serine/threonine protein kinase (AKT)/protein kinase Cζ/λ (PKCζ/λ) in 3T3l1 adipocytes.	PRKCI PRKCZ	3.45e-05	4	84	2	21953448
Pubmed	WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta.	PRKCI PRKCZ	3.45e-05	4	84	2	17313651
Pubmed	Disruption of gene expression rhythms in mice lacking secretory vesicle proteins IA-2 and IA-2β.	INSM1 INSM2	3.45e-05	4	84	2	22785238
Pubmed	Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62.	PRKCI PRKCZ	3.45e-05	4	84	2	26187466
Pubmed	PIP3 but not PIP2 increases GLUT4 surface expression and glucose metabolism mediated by AKT/PKCζ/λ phosphorylation in 3T3L1 adipocytes.	PRKCI PRKCZ	3.45e-05	4	84	2	23749168
Pubmed	Identification of a short Spir interaction sequence at the C-terminal end of formin subgroup proteins.	FMN1 SPIRE1	3.45e-05	4	84	2	19605360
Pubmed	Phosphorylated MARCKS: a novel centrosome component that also defines a peripheral subdomain of the cortical actin cap in mouse eggs.	PRKCI PRKCZ	3.45e-05	4	84	2	15766745
Pubmed	Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι.	PRKCI PRKCZ	3.45e-05	4	84	2	27653691
Pubmed	Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation.	PRKCI PRKCZ	3.45e-05	4	84	2	38815584
Pubmed	Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance.	PRKCI PRKCZ	3.45e-05	4	84	2	30552022
Pubmed	Atypical protein kinase C phosphorylates IKKalphabeta in transformed non-malignant and malignant prostate cell survival.	PRKCI PRKCZ	3.45e-05	4	84	2	18571841
Pubmed	Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.	PRKCI PRKCZ	3.45e-05	4	84	2	9566925
Pubmed	A novel PKC-ι inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma.	PRKCI PRKCZ	3.45e-05	4	84	2	21315177
Pubmed	Par-3 controls tight junction assembly through the Rac exchange factor Tiam1.	PRKCI PRKCZ	3.45e-05	4	84	2	15723052
Pubmed	An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics.	PRKCI PRKCZ	5.74e-05	5	84	2	19668197
Pubmed	Asymmetric division of contractile domains couples cell positioning and fate specification.	PRKCI PRKCZ	5.74e-05	5	84	2	27487217
Pubmed	Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population.	PRKCI PRKCZ	5.74e-05	5	84	2	33207226
Pubmed	Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes.	LAMA4 EZH1	5.74e-05	5	84	2	9584197
Pubmed	A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.	PRKCI PRKCZ	5.74e-05	5	84	2	16792529
Pubmed	mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity.	PRKCI PRKCZ	5.74e-05	5	84	2	24375676
Pubmed	DIDO as a Switchboard that Regulates Self-Renewal and Differentiation in Embryonic Stem Cells.	PRKCI PRKCZ	5.74e-05	5	84	2	28330622
Pubmed	A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1.	PRKCI PRKCZ	5.74e-05	5	84	2	10764742
Pubmed	A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties.	CCND3 LRRN4 UNC5D	6.41e-05	32	84	3	24192035
Pubmed	CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain.	PRKCI PRKCZ	8.59e-05	6	84	2	20152182
Pubmed	PKCzetaII is a target for degradation through the tumour suppressor protein pVHL.	PRKCI PRKCZ	8.59e-05	6	84	2	17350623
Pubmed	A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity.	PRKCI PRKCZ	8.59e-05	6	84	2	10934475
Pubmed	ROCK-nmMyoII, Notch and Neurog3 gene-dosage link epithelial morphogenesis with cell fate in the pancreatic endocrine-progenitor niche.	PRKCI PRKCZ	8.59e-05	6	84	2	30126902
Pubmed	A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene.	HOXB2 HOXA2	8.59e-05	6	84	2	7903601
Pubmed	Gene expression analysis of the embryonic subplate.	AQP11 INSM1 LAMA4 MAPK10 UNC5D	1.16e-04	196	84	5	21862448
Pubmed	The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.	PRKCI PRKCZ	1.20e-04	7	84	2	10356400
Pubmed	A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl.	PRKCI PRKCZ	1.20e-04	7	84	2	12629547
Pubmed	Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve.	HOXB2 HOXA2	1.20e-04	7	84	2	8898234
Pubmed	PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions.	PRKCI PRKCZ	1.20e-04	7	84	2	12459187
Pubmed	Hoxa1 and Krox-20 synergize to control the development of rhombomere 3.	HOXB2 HOXA2	1.20e-04	7	84	2	9806922
Pubmed	Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis.	PRKCI PRKCZ	1.20e-04	7	84	2	24153433
Pubmed	Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction.	PRKCI PRKCZ	1.60e-04	8	84	2	20463008
Pubmed	Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C.	PRKCI PRKCZ	1.60e-04	8	84	2	12893243
Pubmed	The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis.	DDX12P DDX11	1.60e-04	8	84	2	22678773
Pubmed	The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development.	PRKCI PRKCZ	1.60e-04	8	84	2	10882525
Pubmed	Identification of PKCzetaII: an endogenous inhibitor of cell polarity.	PRKCI PRKCZ	1.60e-04	8	84	2	14685273
Pubmed	Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse.	HOXB2 HOXA2	1.60e-04	8	84	2	10662633
Pubmed	Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein.	CPSF3 SMAD4	1.60e-04	8	84	2	16115198
Pubmed	Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.	PRKCI PRKCZ	1.60e-04	8	84	2	11260256
Pubmed	Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling.	PRKCI PRKCZ	1.60e-04	8	84	2	10383403
Pubmed	Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins.	PRKCI PRKCZ	2.05e-04	9	84	2	12813044
Pubmed	The Apical Domain Is Required and Sufficient for the First Lineage Segregation in the Mouse Embryo.	PRKCI PRKCZ	2.05e-04	9	84	2	28171747
Pubmed	Identification of a novel member of the snail/Gfi-1 repressor family, mlt 1, which is methylated and silenced in liver tumors of SV40 T antigen transgenic mice.	INSM1 INSM2	2.05e-04	9	84	2	11221845
Pubmed	Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein.	PRKCI PRKCZ	2.05e-04	9	84	2	7850771
Pubmed	Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report.	PRKCI PRKCZ	2.05e-04	9	84	2	8206685
Pubmed	Ror2 is required for midgut elongation during mouse development.	PRKCI PRKCZ	2.05e-04	9	84	2	20063415
Pubmed	In vivo functional analysis of the Hoxa-1 3' retinoic acid response element (3'RARE).	HOXB2 HOXA2	2.05e-04	9	84	2	9053316
Pubmed	Regulation of HIV-1 gag protein subcellular targeting by protein kinase C.	PRKCI PRKCZ	2.05e-04	9	84	2	7876252
Pubmed	Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defects.	PRKCI PRKCZ	2.05e-04	9	84	2	21423666
Pubmed	Protein tyrosine kinase 7 is essential for tubular morphogenesis of the Wolffian duct.	PRKCI PRKCZ	2.05e-04	9	84	2	26944093
Pubmed	Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia.	HOXB2 HOXA2	2.05e-04	9	84	2	12242306
Pubmed	Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1.6) mutant embryos.	HOXB2 HOXA2	2.05e-04	9	84	2	8102800
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF567 ZNF878 ZNF778 INSM2 ZBTB26 ZNF226 ZNF333 ZNF774 ZNF835 ZNF441 ZNF513	2.87e-05	718	62	11	28
GeneFamily	Zinc fingers C2H2-type\|SNAG transcriptional repressors	INSM1 INSM2	5.12e-04	10	62	2	1259
GeneFamily	WD repeat domain containing	WDR45 DCAF8L2 FBXW5 CFAP44 DMXL1	2.03e-03	262	62	5	362
ToppCell	COVID-19-kidney-Plasma\|COVID-19 / Disease (COVID-19 only), tissue and cell type	WNT5B AMPD1 EAF2 SLC15A2 TPTE2 ANKRD28	5.95e-07	160	84	6	f8d9e459976e711e9ad39ea2b6173140c0589d6e
ToppCell	3'_v3-blood-Lymphocytic_T_CD4-Trm_Th1/Th17\|blood / Manually curated celltypes from each tissue	WNT5B PTPN13 HLA-DRB5 ANKRD28 ZNF774	1.06e-05	153	84	5	d09bc7322b59f613d66673359ee6af1aea99ce87
ToppCell	Control-B_cells-Plasma_cells\|Control / group, cell type (main and fine annotations)	WNT5B AMPD1 EAF2 TPTE2 ANKRD28	2.02e-05	175	84	5	fb23858cfce71509cafbe0d9728e678012ff2962
ToppCell	nucseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	WNT5B AMPD1 EAF2 TPTE2 ANKRD28	2.64e-05	185	84	5	3b77bc49cd3740acc025e162a36282ac09e12198
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CCND3 PTPN13 FMN1 C4BPA PRKCZ	2.78e-05	187	84	5	5df9e1f5ca32217af255e76e6fb5afa346337811
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-B_cell-B_cell\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	THRB INSM1 BCAN CFAP44 ZNF441	2.85e-05	188	84	5	99fdd305f75ed38dd507e7a17ffe27c26b86e454
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-B_cell\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	THRB INSM1 BCAN CFAP44 ZNF441	2.85e-05	188	84	5	5a0519b189e96001d95f9d24363448e8602b8d4d
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-B_cell-B_cell-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	THRB INSM1 BCAN CFAP44 ZNF441	2.85e-05	188	84	5	e8b7c1c2eb2e390ad79b358236468b0f15ea58a5
ToppCell	COVID-19-lung-Plasma_cells_PRDM1/BLIMP_hi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	WNT5B EAF2 SLC15A2 ANKRD28 DDX11	2.85e-05	188	84	5	567b08514d9d84cbb40f9b7a679eec304f023428
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CCND3 PTPN13 FMN1 PRKCI PRKCZ	3.00e-05	190	84	5	8aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RNF113B HLA-DRB5 BARD1 KDM4B DMXL1	3.00e-05	190	84	5	ed100e271aac82806f59e0c613ccda63f59100c1
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination__)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCND3 WDR45 AQP11 GZMA RPS17	3.00e-05	190	84	5	2f5460fa028dfe6b80dd024063a4513dc532a94d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 TMEM178A FMN1 SPIRE1 MAPK10	3.00e-05	190	84	5	4836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	WNT5B AMPD1 EAF2 SLC15A2 BCAN	3.48e-05	196	84	5	fd18a9ae8401121ae276adff1a85d5f938e2df91
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	WNT5B AMPD1 EAF2 SLC15A2 TPTE2	3.57e-05	197	84	5	749e0e332644543cbdf2ee38c2b301ce0a019a7f
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTPN13 TMC2 NDST4 PRKCZ	3.57e-05	98	84	4	ffe21b3681fdeaf4a8447bd2b13772d03cdd45aa
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_plasma\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	WNT5B AMPD1 EAF2 SLC15A2 TPTE2	3.65e-05	198	84	5	567fcf882c8612356946240843525b786f3c8dbe
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PTPN13 FMN1 SPIRE1 C4BPA MAPK10	3.65e-05	198	84	5	2e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PTPN13 PRKCI C4BPA PRKCZ MAPK10	3.74e-05	199	84	5	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PTPN13 FMN1 PRKCI C4BPA PRKCZ	3.74e-05	199	84	5	8587bd98de7767a575088afbea07a1feb4516b9b
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PTPN13 FMN1 PRKCI PRKCZ MAPK10	3.74e-05	199	84	5	5cea0d9e261903e0eaad60c28a07dff72ce65027
Disease	Warsaw breakage syndrome (implicated_via_orthology)	DDX12P DDX11	2.23e-05	3	81	2	DOID:0060535 (implicated_via_orthology)
Disease	high grade glioma (implicated_via_orthology)	PRKCI BCAN PRKCZ	2.43e-04	44	81	3	DOID:3070 (implicated_via_orthology)
Disease	colorectal cancer (is_implicated_in)	SETD2 MLH3 PTPN13 KDM4B	3.51e-04	121	81	4	DOID:9256 (is_implicated_in)
Disease	prostate cancer (is_marker_for)	CCND3 EAF2 CXCL12 KDM4B	9.12e-04	156	81	4	DOID:10283 (is_marker_for)
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	SETD2 KDM4B	9.85e-04	17	81	2	DOID:0060307 (is_implicated_in)
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	MLH3 BARD1	1.23e-03	19	81	2	C1333991
Disease	Colorectal cancer, hereditary nonpolyposis, type 1	MLH3 BARD1	1.23e-03	19	81	2	C2936783
Disease	hemoglobin measurement, mean corpuscular hemoglobin	CCND3 THRB	1.66e-03	22	81	2	EFO_0004509, EFO_0004527
Disease	Lynch syndrome (is_implicated_in)	MLH3 SMAD4	1.98e-03	24	81	2	DOID:3883 (is_implicated_in)
Disease	breast carcinoma (is_implicated_in)	THRB CXCL12	2.14e-03	25	81	2	DOID:3459 (is_implicated_in)
Disease	breast cancer (implicated_via_orthology)	THRB BARD1	2.14e-03	25	81	2	DOID:1612 (implicated_via_orthology)
Disease	brain cancer (implicated_via_orthology)	INSM1 INSM2	2.32e-03	26	81	2	DOID:1319 (implicated_via_orthology)
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	MLH3 BARD1	2.32e-03	26	81	2	C0009405
Disease	Adenocarcinoma of large intestine	MLH3 PRKCZ SMAD4	2.37e-03	96	81	3	C1319315
Disease	Hereditary non-polyposis colorectal cancer syndrome	MLH3 BARD1	2.50e-03	27	81	2	C1112155

Protein segments in the cluster

Peptide	Gene	Start	Entry
YTRLGNDFHTNKRVC	RPS17	21	P08708
TQHRKSRPANHCVYF	C4BPA	376	P04003
RASYFQCVQREIKPH	CCND3	41	P30281
AYHARPDSDQRFCTQ	BARD1	721	Q99728
VKRNFNYHILSPCDL	CPSF3	486	Q9UKF6
QPSFARCISNEYRHL	ADGRB3	561	O60242
RKVCNDRNHYNFNPV	GZMA	176	P12544
KFGRSPLHYAAANCN	ANKRD28	436	O15084
LKNNPHRDFYNCRKV	AMPD1	286	P23109
DFARRLCEHKYGNAP	BCKDK	236	O14874
CAHTNRLAVAYKQPA	DMXL1	1051	Q9Y485
VHSFGYDCRKRANLQ	CFAP44	136	Q96MT7
DRSNKGFHNCYQVRE	FMN1	41	Q68DA7
FPNKHSRFNVYCFRD	BCAN	341	Q96GW7
QAKHAVSNFCRYDPR	KLHL31	381	Q9H511
YCANGHTFQAKRFNR	PRKCI	136	P41743
GYAQSCRFKRVQQRH	MAFA	266	Q8NHW3
DTRPRFLQQDKYECH	HLA-DRB5	31	Q30154
SRPFQNQTHAKRAYR	MAPK10	96	P53779
QCPYDKNHQIRACRF	GTSF1	16	Q8WW33
SYFNNTKCVAQHRGP	DCAF8L2	306	P0C7V8
RAHRAYTPNDECFFI	FBXW5	461	Q969U6
HCARAAKQTPSQYLA	CBFA2T2	191	O43439
SKCHSVQDLENPRFY	MLH3	76	Q9UHC1
VNCSTPANYFHVLRR	OGDHL	816	Q9ULD0
IYKVCHANPSERARF	COPB1	231	P53618
AACEAHYSTKNPRAI	MSL3	506	Q8N5Y2
LANSEKYCTPRHQDF	KDM4B	101	O94953
RKFNAAAARTEPYCA	KDM4B	671	O94953
KSANYFHSEEAPRRA	NDST4	666	Q9H3R1
RRRQEKQAACPFYNH	DDX11	306	Q96FC9
RQSFQNPVVTKCRHY	RNF113A	266	O15541
QYADPFALAQHRCSR	INSM2	271	Q96T92
EFHFNKYLCRPRRVE	HOXB2	161	P14652
RHFNDPNADAYFTKR	PAN3	581	Q58A45
PNCSNRCFHAKYRAH	PXDNL	716	A1KZ92
ANRKRECGNAHYQRA	FKBP8	221	Q14318
QPRCAFHTVRYDFKP	EAF2	26	Q96CJ1
RYTCQREFALKHLPN	CS	356	O75390
RRQEKQAACPFYNHE	DDX12P	326	Q92771
KSDSVHLYCNPVNFR	DNAAF9	101	Q5TEA3
SYRNNFNKRLHTCLP	MBTPS2	346	O43462
EAKNRKYNPSSFHRC	EFHB	431	Q8N7U6
YPAVHCRTEDKNFSL	SLC15A2	556	Q16348
FRQIKRHCAEPFTEY	NDUFA8	71	P51970
SPEKVNCSYHRLAAF	PKD1L1	1711	Q8TDX9
SPLTQHFQNSRRYCD	POPDC3	276	Q9HBV1
RCDTHLVAYKNPAFD	LRRN4	716	Q8WUT4
HIRNSNCAPSFSYVK	PTPN13	156	Q12923
LPHLANFAESCYRKN	LAMA4	136	Q16363
YADPFALAQHKCSRI	INSM1	276	Q01101
EFHFNKYLCRPRRVE	HOXA2	161	O43364
CTNRPFYRIVAAHNK	MRPS16	26	Q9Y3D3
DHVSFYCKTAPNRAI	SAMHD1	516	Q9Y3Z3
QAFQNPVVTKCRHYF	RNF113B	261	Q8IZP6
AQRCTAIKYHFSQPI	TMEM178A	136	Q8NBL3
RNEKHCRNCFYPTLN	PKDREJ	876	Q9NTG1
PSAYIKVFDLRQCHR	SMAD4	431	Q13485
FPKIHSRRFRDYCSQ	SECISBP2	621	Q96T21
TFHKYVFTPDGNCNR	WDR45	331	Q9Y484
YHVSERSFACKNPIR	AQP11	146	Q8NBQ7
FYNRPLHCVFNDTRL	CNNM1	501	Q9NRU3
ARCPYASAHLDNLKR	ZNF513	391	Q8N8E2
CGNAFRRKSYLIDHQ	ZNF567	286	Q8N184
REITNYRARHQKCNF	SENP5	546	Q96HI0
QCGKAFRSSNYIRVH	ZNF441	451	Q8N8Z8
VSNHYERDFFIPCQK	ZNF778	146	Q96MU6
GKYFRNSSCLNNHVR	ZNF778	371	Q96MU6
SDAPNHYQAVCRALF	SPIRE1	211	Q08AE8
YRCPECGKTFNQRSH	ZNF774	431	Q6NX45
FRRTIQKNLHPSYSC	THRB	131	P10828
RFANHSVNPNCYAKV	EZH1	686	Q92800
RGYNQFKSVQVERCH	WNT5B	321	Q9H1J7
SNRQPLHCAFSLERY	UNC5D	781	Q6UXZ4
GDYCSNRRFQRKQHA	SETD2	1536	Q9BYW2
RPYQCNQCEKAFRHS	ZNF333	616	Q96JL9
NECGKSFRRNSHYQV	ZNF226	506	Q9NYT6
PYACAQCAKAFRNRS	ZNF835	221	Q9Y2P0
LCSERAYDPKHFHNR	TPTE2	266	Q6XPS3
QQPKCKSHSSRAAAY	USP34	1831	Q70CQ2
PHERVFKASRSNNFY	TMC2	681	Q8TDI7
FALNRCEKPIQDSHY	RPTN	226	Q6XPR3
PCRFFESHVARANVK	CXCL12	31	P48061
PKCTRVFRHLENYAN	ZBTB26	276	Q9HCK0
DKAFNCPSSFQYHER	ZNF878	261	C9JN71
HLFQAKRFNRRAYCG	PRKCZ	131	Q05513