Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K27me2/H3K27me3 demethylase activity	KDM6A UTY	4.51e-05	5	43	2	GO:0071558
GeneOntologyMolecularFunction	racemase and epimerase activity, acting on carbohydrates and derivatives	DSEL GFUS	2.46e-04	11	43	2	GO:0016857
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	GALNT15 A4GNT GCNT3 UGT3A1	3.24e-04	153	43	4	GO:0008194
GeneOntologyMolecularFunction	racemase and epimerase activity	DSEL GFUS	6.78e-04	18	43	2	GO:0016854
GeneOntologyMolecularFunction	hexosyltransferase activity	GALNT15 A4GNT GCNT3 UGT3A1	1.08e-03	211	43	4	GO:0016758
GeneOntologyMolecularFunction	phosphatidylinositol kinase activity	PIK3C2B PIP4K2A	1.42e-03	26	43	2	GO:0052742
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM6A UTY	1.65e-03	28	43	2	GO:0141052
GeneOntologyMolecularFunction	histone demethylase activity	KDM6A UTY	2.02e-03	31	43	2	GO:0032452
GeneOntologyMolecularFunction	protein demethylase activity	KDM6A UTY	2.16e-03	32	43	2	GO:0140457
GeneOntologyMolecularFunction	lipase activity	GDPD5 LIPK ABHD11	3.26e-03	138	43	3	GO:0016298
GeneOntologyMolecularFunction	glycosyltransferase activity	GALNT15 A4GNT GCNT3 UGT3A1	3.36e-03	288	43	4	GO:0016757
GeneOntologyMolecularFunction	lipid kinase activity	PIK3C2B PIP4K2A	3.52e-03	41	43	2	GO:0001727
GeneOntologyMolecularFunction	demethylase activity	KDM6A UTY	4.05e-03	44	43	2	GO:0032451
GeneOntologyMolecularFunction	protein-membrane adaptor activity	SPTBN4 SYNE1	4.23e-03	45	43	2	GO:0043495
GeneOntologyMolecularFunction	acetylglucosaminyltransferase activity	A4GNT GCNT3	4.60e-03	47	43	2	GO:0008375
GeneOntologyMolecularFunction	carboxylic ester hydrolase activity	NDST1 LIPK ABHD11	4.67e-03	157	43	3	GO:0052689
GeneOntologyMolecularFunction	chromatin DNA binding	SUZ12 KDM6A UTY	5.55e-03	167	43	3	GO:0031490
GeneOntologyMolecularFunction	sulfotransferase activity	NDST1 DSEL	6.26e-03	55	43	2	GO:0008146
GeneOntologyCellularComponent	MLL3/4 complex	KDM6A UTY	3.08e-04	12	46	2	GO:0044666
GeneOntologyCellularComponent	histone methyltransferase complex	SUZ12 KDM6A UTY	6.03e-04	75	46	3	GO:0035097
Domain	LRRC37_N	LRRC37A LRRC37B LRRC37A3 LRRC37A2	3.52e-11	4	47	4	IPR032754
Domain	LRRC37AB_C	LRRC37A LRRC37B LRRC37A3 LRRC37A2	3.52e-11	4	47	4	PF14914
Domain	LRRC37AB_C	LRRC37A LRRC37B LRRC37A3 LRRC37A2	3.52e-11	4	47	4	IPR029423
Domain	LRRC37	LRRC37A LRRC37B LRRC37A3 LRRC37A2	3.52e-11	4	47	4	PF15779
Domain	LRRC37A/B-like	LRRC37A LRRC37B LRRC37A3 LRRC37A2	3.52e-11	4	47	4	IPR015753
Domain	LRR	PPP1R37 LRRC37A LRRC37B LRRC37A3 LRRC37A2	1.46e-04	201	47	5	PS51450
Domain	Leu-rich_rpt	PPP1R37 LRRC37A LRRC37B LRRC37A3 LRRC37A2	5.78e-04	271	47	5	IPR001611
Domain	PI3/4_kinase_CS	SMG1 PIK3C2B	6.37e-04	15	47	2	IPR018936
Domain	PI3Kc	SMG1 PIK3C2B	7.27e-04	16	47	2	SM00146
Domain	-	SMG1 PIK3C2B	7.27e-04	16	47	2	1.10.1070.11
Domain	LRR_8	LRRC37A LRRC37B LRRC37A3 LRRC37A2	8.90e-04	171	47	4	PF13855
Domain	PI3_4_KINASE_1	SMG1 PIK3C2B	9.24e-04	18	47	2	PS00915
Domain	PI3_4_KINASE_2	SMG1 PIK3C2B	9.24e-04	18	47	2	PS00916
Domain	PI3/4_kinase_cat_dom	SMG1 PIK3C2B	9.24e-04	18	47	2	IPR000403
Domain	PI3_PI4_kinase	SMG1 PIK3C2B	9.24e-04	18	47	2	PF00454
Domain	PI3_4_KINASE_3	SMG1 PIK3C2B	9.24e-04	18	47	2	PS50290
Domain	Leu-rich_rpt_typical-subtyp	LRRC37A LRRC37B LRRC37A3 LRRC37A2	1.01e-03	177	47	4	IPR003591
Domain	LRR_TYP	LRRC37A LRRC37B LRRC37A3 LRRC37A2	1.01e-03	177	47	4	SM00369
Domain	-	PPP1R37 LRRC37A LRRC37B LRRC37A3 LRRC37A2	1.23e-03	321	47	5	3.80.10.10
Domain	L_dom-like	PPP1R37 LRRC37A LRRC37B LRRC37A3 LRRC37A2	1.36e-03	328	47	5	IPR032675
Domain	Actinin_actin-bd_CS	SPTBN4 SYNE1	1.52e-03	23	47	2	IPR001589
Domain	ACTININ_2	SPTBN4 SYNE1	1.52e-03	23	47	2	PS00020
Domain	ACTININ_1	SPTBN4 SYNE1	1.52e-03	23	47	2	PS00019
Domain	Spectrin	SPTBN4 SYNE1	1.52e-03	23	47	2	PF00435
Domain	JmjC	KDM6A UTY	1.65e-03	24	47	2	PF02373
Domain	LRR_1	LRRC37A LRRC37B LRRC37A3 LRRC37A2	2.21e-03	219	47	4	PF00560
Domain	Spectrin_repeat	SPTBN4 SYNE1	2.41e-03	29	47	2	IPR002017
Domain	Abhydrolase_1	LIPK ABHD11	2.75e-03	31	47	2	PF00561
Domain	JMJC	KDM6A UTY	2.93e-03	32	47	2	PS51184
Domain	JmjC_dom	KDM6A UTY	2.93e-03	32	47	2	IPR003347
Domain	Spectrin/alpha-actinin	SPTBN4 SYNE1	2.93e-03	32	47	2	IPR018159
Domain	SPEC	SPTBN4 SYNE1	2.93e-03	32	47	2	SM00150
Domain	JmjC	KDM6A UTY	3.11e-03	33	47	2	SM00558
Domain	AB_hydrolase_1	LIPK ABHD11	3.11e-03	33	47	2	IPR000073
Domain	Sulfotransferase_dom	NDST1 DSEL	3.70e-03	36	47	2	IPR000863
Domain	Sulfotransfer_1	NDST1 DSEL	3.70e-03	36	47	2	PF00685
Domain	TPR_8	KDM6A UTY	7.87e-03	53	47	2	PF13181
Domain	CH	SPTBN4 SYNE1	1.17e-02	65	47	2	SM00033
Domain	CH	SPTBN4 SYNE1	1.34e-02	70	47	2	PF00307
Domain	-	SPTBN4 SYNE1	1.38e-02	71	47	2	1.10.418.10
Domain	CH	SPTBN4 SYNE1	1.45e-02	73	47	2	PS50021
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A LRRC37B LRRC37A3 LRRC37A2	6.11e-10	10	47	4	23064749
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A LRRC37A3 LRRC37A2	9.24e-09	4	47	3	22419166
Pubmed	Positive and negative selection on mammalian Y chromosomes.	KDM6A UTY	1.79e-06	2	47	2	15758204
Pubmed	Lysine demethylases KDM6A and UTY: The X and Y of histone demethylation.	KDM6A UTY	1.79e-06	2	47	2	31097364
Pubmed	Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons.	KDM6A UTY	1.79e-06	2	47	2	18434530
Pubmed	Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer.	KDM6A UTY	1.79e-06	2	47	2	27533081
Pubmed	An H-YDb epitope is encoded by a novel mouse Y chromosome gene.	KDM6A UTY	1.79e-06	2	47	2	8944031
Pubmed	The UTX gene escapes X inactivation in mice and humans.	KDM6A UTY	5.36e-06	3	47	2	9499428
Pubmed	X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.	KDM6A UTY	1.07e-05	4	47	2	32732223
Pubmed	Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility.	KDM6A UTY	1.07e-05	4	47	2	10767340
Pubmed	Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms.	KDM6A UTY	1.07e-05	4	47	2	9854018
Pubmed	Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes.	SUZ12 KDM6A	1.78e-05	5	47	2	19575012
Pubmed	UTX Affects Neural Stem Cell Proliferation and Differentiation through PTEN Signaling.	KDM6A UTY	3.74e-05	7	47	2	29551674
Pubmed	UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death.	KDM6A UTY	4.98e-05	8	47	2	36412518
Pubmed	UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development.	KDM6A UTY	6.40e-05	9	47	2	23028370
Pubmed	UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity.	KDM6A UTY	6.40e-05	9	47	2	22949634
Pubmed	Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth.	SUZ12 LRRC37B	1.17e-04	12	47	2	17632510
Pubmed	Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.	KDM6A UTY	1.38e-04	13	47	2	14660691
Pubmed	UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program.	KDM6A UTY	1.38e-04	13	47	2	22192413
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	CKS2 SUZ12 ZFHX4 KDM6A PIP4K2A	1.98e-04	398	47	5	35016035
Pubmed	KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis.	KDM6A UTY	2.12e-04	16	47	2	35212626
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	KDM6A UTY	2.70e-04	18	47	2	12023983
Pubmed	Liganded ERα Stimulates the E3 Ubiquitin Ligase Activity of UBE3C to Facilitate Cell Proliferation.	PPP2R3A SUZ12	3.01e-04	19	47	2	26389696
Pubmed	The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.	ZFHX4 KDM6A	3.34e-04	20	47	2	35177643
Pubmed	Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.	KDM6A UTY	3.34e-04	20	47	2	19047629
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ARHGAP39 SYNE1 KLHL4	3.62e-04	102	47	3	11214970
Pubmed	DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.	SPTBN4 SYNE1	4.06e-04	22	47	2	12812986
Pubmed	Functional coherence of the human Y chromosome.	KDM6A UTY	5.26e-04	25	47	2	9381176
Pubmed	Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.	SUZ12 ARHGAP39	6.14e-04	27	47	2	19026994
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	NUP188 SYNE1 RRP1 PIP4K2A	1.05e-03	332	47	4	25693804
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM6A UTY	8.70e-04	24	33	2	485
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPTBN4 GDPD5 SARDH LRRC37B	2.15e-05	155	47	4	51f6447945389649d99dcf7603b396195c631ead
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic-Mast_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPTBN4 GDPD5 SARDH LRRC37B	2.15e-05	155	47	4	23dc71cab28094ca0ac4d2baf4e24871ed107781
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	SMG1 LRRC37A KDM6A UTY	2.56e-05	162	47	4	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	normal-na-Lymphocytic_T-T4_reg-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	CPA6 ARHGAP39 UTY KLHL4	2.62e-05	163	47	4	43887e7687fc6367efac0c1f56a9534b06f47b7f
ToppCell	metastatic_Brain-Myeloid_cells-pDCs\|metastatic_Brain / Location, Cell class and cell subclass	LRRC37A KCNK17 UTY SDR42E2	2.69e-05	164	47	4	06db4cc064f0765c481ce880207823872c27bfa9
ToppCell	metastatic_Brain-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	LRRC37A KCNK17 UTY SDR42E2	2.95e-05	168	47	4	4bf3f85aac4b335efa93d22c9ce7b153cb5ce152
ToppCell	ASK452-Immune-B_cell\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	KCNK17 LRRC37A3 KDM6A LRRC37A2	3.39e-05	174	47	4	69723f5666abc3af5f0431901a60246c9915ef81
ToppCell	3'_v3-blood-Lymphocytic_T_CD8\|blood / Manually curated celltypes from each tissue	DSEL UTY SYNE1 PIP4K2A	4.77e-05	190	47	4	5dca8654964c41580fa3b094579fe7cb296d406f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GALNT15 PIK3C2B SYNE1 PIP4K2A	5.07e-05	193	47	4	456aa8a8f1f9cbba0bd618a5f623909079c0f56b
ToppCell	facs-Thymus-nan-3m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 UTY NPEPPS PIP4K2A	5.17e-05	194	47	4	f1661f9f2439fca5c1012c693b0744c4e3b90a9b
ToppCell	facs-Thymus-nan-3m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 UTY NPEPPS PIP4K2A	5.17e-05	194	47	4	66c056232ac216780acf4cc8ea325bd8ed1909c9
ToppCell	facs-Thymus-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 UTY NPEPPS PIP4K2A	5.17e-05	194	47	4	cda1b197efb199330ea7ab25a7cee22cae22589d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GALNT15 PIK3C2B SYNE1 PIP4K2A	5.17e-05	194	47	4	a52c5906fce43c2f72cf7e463a3d15cde06431f6
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SMG1 SYNE1 PIP4K2A TXK	5.38e-05	196	47	4	a9157809122e6fc5783a291522f103bef30943e4
ToppCell	severe_influenza-NK\|World / disease group, cell group and cell class (v2)	SYNE1 PIP4K2A KLHL4 TXK	5.49e-05	197	47	4	8e86a1ee0418e153d4f0bf291006cffc6cf36f71
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 UTY SYNE1 TXK	5.71e-05	199	47	4	f0b0097df0026496470a80d8cc9375ffd8389b00
Disease	Kabuki syndrome (implicated_via_orthology)	KDM6A UTY	7.13e-06	3	46	2	DOID:0060473 (implicated_via_orthology)
Disease	Ischemic stroke, fibrinogen measurement	MS4A4A PPP2R3A	3.35e-03	55	46	2	EFO_0004623, HP_0002140
Disease	family history of Alzheimer’s disease	PPP1R37 MS4A4A	5.52e-03	71	46	2	EFO_0009268
Disease	Alzheimer disease	PPP1R37 MS4A4A ANKRD55 KLHL4	6.82e-03	485	46	4	MONDO_0004975
Disease	post-traumatic stress disorder symptom measurement	SYNE1 LRRC37A2	7.29e-03	82	46	2	EFO_0008535

Protein segments in the cluster

Peptide	Gene	Start	Entry
AQMQTVPNAGHWIHA	ABHD11	286	Q8NFV4
ALHLWNHMNQEGRAV	A4GNT	286	Q9UNA3
NHGVHFMAAIAFVWN	DOP1A	1821	Q5JWR5
LHWAAFHNQPQHTQM	ANKRD55	166	Q3KP44
QNWMHHLNKTHSGLI	CPA6	146	Q8N4T0
QARLAWEAQQAHFHM	ARHGAP39	556	Q9C0H5
TFQAWHGMQFLHKLI	LRRC37A3	956	O60309
TFQAWHGMQFLHKLI	LRRC37A2	956	A6NM11
TFQAWHGMQFLHKLI	LRRC37A	956	A6NMS7
LQQLGWMHHTVDLLG	KDM6A	246	O15550
AIHQQHWDFQENGMI	GALNT15	581	Q8N3T1
LGHLMQQGVNHWASR	KCNK17	151	Q96T54
HILGTVLQMHSAQAW	OR2V2	221	Q96R30
WSHMQPHLFHNQSVL	NDST1	391	P52848
TFQAWHGMQFLHNLI	LRRC37B	646	Q96QE4
HIAVGQQMNLHWLHK	GDPD5	111	Q8WTR4
QQMNLHWLHKIGLVV	GDPD5	116	Q8WTR4
FWRKNVHMNDNVLHS	GFUS	86	Q13630
GHELAHQWFGNLVTM	NPEPPSL1	351	A6NEC2
GAWTFANLQQNHLMG	HELZ	1681	P42694
QSFIAMWRKLLNNHH	PPP2R3A	781	Q06190
FHALMQWVGHDVQNR	KLHL4	346	Q9C0H6
KQWTHMNHQDALGLL	PIK3C2B	876	O00750
LGLKWHQMVNNICQF	P2RY13	201	Q9BPV8
VLWNNQLTHTGMAFL	PPP1R37	311	O75864
HHVVWSLFNTLFMNP	nan	56	C9JQL5
GDLNWMLQNHHLLAN	GCNT3	396	O95395
GNMAVIHSHLWKGLQ	MS4A4A	41	Q96JQ5
ARMNWVHVHNLVQAH	SDR42E2	241	A6NKP2
HVFHQNCIVMWLAGG	RNF103	641	O00237
WGKQLLHNHQATNMI	DSEL	216	Q8IZU8
GHELAHQWFGNLVTM	NPEPPS	351	P55786
LMWGVNHSINELSHV	PIP4K2A	41	P48426
TVLQQLGWMHHNMDL	UTY	241	O14607
ELGWKFLNLMHHNQQ	TCP11X2	366	Q5H9J9
FFRNLPHWIQQHTAM	SYNE1	646	Q8NF91
HLNAMGFHVILVNNW	FASTKD2	661	Q9NYY8
QRVQLHIAMFQWQHE	SMG1	3191	Q96Q15
HIAMFQWQHEDLLIN	SMG1	3196	Q96Q15
AQHLFLQAFWQTMNR	RRP1	91	P56182
LAMGGAVAQHNWSHI	SARDH	646	Q9UL12
LGVQQSLGWVHYMIH	CKS2	46	P33552
MQKHRVVAWLSQHNF	PITPNM1	1071	O00562
MHNAFAHLPQGVIWT	UGT3A1	316	Q6NUS8
ELWQEHQHMHFLAAQ	ZFHX4	2461	Q86UP3
HAWVQNHGAGLFVMI	TAS1R1	671	Q7RTX1
LWNLHVMKHGFIADN	SUZ12	616	Q15022
WHFHLPQLMRDIQVN	NUP188	1466	Q5SRE5
QWMQKLHDQLELQHF	SPTBN4	1296	Q9H254
ELIWYHQHNAAGLMT	TXK	226	P42681
MLHWAQAVNSGQLQA	LIPK	291	Q5VXJ0