Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncysteine-type deubiquitinase activity

USP6 USP2 USP8 USP22 USP51 USP11 USP4 USP27X USP15 USP3

2.58e-131145110GO:0004843
GeneOntologyMolecularFunctiondeubiquitinase activity

USP6 USP2 USP8 USP22 USP51 USP11 USP4 USP27X USP15 USP3

6.08e-131245110GO:0101005
GeneOntologyMolecularFunctionubiquitin-like protein peptidase activity

USP6 USP2 USP8 USP22 USP51 USP11 USP4 USP27X USP15 USP3

1.67e-121375110GO:0019783
GeneOntologyMolecularFunctioncysteine-type peptidase activity

USP6 USP2 USP8 USP22 USP51 USP11 USP4 USP27X USP15 USP3

4.85e-111925110GO:0008234
GeneOntologyMolecularFunctioncysteine-type endopeptidase activity

USP6 USP2 USP8 USP11 USP27X USP15

8.24e-0886516GO:0004197
GeneOntologyMolecularFunctionhistone H2A deubiquitinase activity

USP22 USP51 USP3

3.12e-076513GO:0140950
GeneOntologyMolecularFunctionhistone deubiquitinase activity

USP22 USP51 USP3

8.71e-078513GO:0140934
GeneOntologyMolecularFunctionpeptidase activity

USP6 USP2 USP8 USP22 USP51 USP11 USP4 USP27X USP15 USP3

5.04e-066545110GO:0008233
GeneOntologyMolecularFunctionK48-linked deubiquitinase activity

USP8 USP27X USP15

2.02e-0521513GO:1990380
GeneOntologyMolecularFunctionhistone H4 acetyltransferase activity

USP22 BRPF1 BRD1

2.68e-0523513GO:0010485
GeneOntologyMolecularFunctionhistone H2B deubiquitinase activity

USP22 USP3

3.82e-054512GO:0140936
GeneOntologyMolecularFunctionhistone modifying activity

USP22 USP51 BRPF1 BRD1 USP3

2.90e-04229515GO:0140993
GeneOntologyMolecularFunctionhistone acetyltransferase activity

USP22 BRPF1 BRD1

3.00e-0451513GO:0004402
GeneOntologyMolecularFunctionhistone H4K8 acetyltransferase activity

BRPF1 BRD1

3.47e-0411512GO:0043996
GeneOntologyMolecularFunctionhistone H4K5 acetyltransferase activity

BRPF1 BRD1

3.47e-0411512GO:0043995
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

USP22 BRPF1 BRD1

3.75e-0455513GO:0061733
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

FBN1 FBN2

4.15e-0412512GO:0030023
GeneOntologyMolecularFunctionhistone H4K12 acetyltransferase activity

BRPF1 BRD1

4.15e-0412512GO:0043997
GeneOntologyMolecularFunctionCCR1 chemokine receptor binding

CCL3 CCL3L1

4.15e-0412512GO:0031726
GeneOntologyMolecularFunctionpeptide N-acetyltransferase activity

USP22 BRPF1 BRD1

4.85e-0460513GO:0034212
GeneOntologyMolecularFunctionCCR5 chemokine receptor binding

CCL3 CCL3L1

4.90e-0413512GO:0031730
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

FBN1 FBN2

5.71e-0414512GO:0097493
GeneOntologyMolecularFunctionK63-linked deubiquitinase activity

USP8 USP27X

7.50e-0416512GO:0061578
GeneOntologyMolecularFunctionendopeptidase activity

USP6 USP2 USP8 USP11 USP27X USP15

7.64e-04430516GO:0004175
GeneOntologyMolecularFunctionN-acetyltransferase activity

USP22 BRPF1 BRD1

1.04e-0378513GO:0008080
GeneOntologyMolecularFunctionextracellular matrix structural constituent

FBN1 FBN2 COL15A1 LAMA1

1.35e-03188514GO:0005201
GeneOntologyMolecularFunctionphospholipase activator activity

CCL3 CCL3L1

1.56e-0323512GO:0016004
GeneOntologyMolecularFunctionhistone reader activity

BRD1 USP15

2.00e-0326512GO:0140566
GeneOntologyMolecularFunctionlipase activator activity

CCL3 CCL3L1

2.16e-0327512GO:0060229
GeneOntologyMolecularFunctionN-acyltransferase activity

USP22 BRPF1 BRD1

2.26e-03102513GO:0016410
GeneOntologyMolecularFunctionacetyltransferase activity

USP22 BRPF1 BRD1

2.38e-03104513GO:0016407
GeneOntologyMolecularFunctionchromatin-protein adaptor activity

BRD1 USP15

4.92e-0341512GO:0140463
GeneOntologyMolecularFunctionchemokine activity

CCL3 CCL3L1

7.53e-0351512GO:0008009
GeneOntologyMolecularFunctionionotropic glutamate receptor binding

NETO2 NETO1

7.82e-0352512GO:0035255
GeneOntologyMolecularFunctionchemoattractant activity

CCL3 CCL3L1

8.41e-0354512GO:0042056
GeneOntologyMolecularFunctionCCR chemokine receptor binding

CCL3 CCL3L1

9.02e-0356512GO:0048020
GeneOntologyBiologicalProcessprotein deubiquitination

USP6 USP2 USP8 USP22 USP51 USP11 USP4 USP27X USP15 USP3

4.80e-131255110GO:0016579
GeneOntologyBiologicalProcessprotein modification by small protein removal

USP6 USP2 USP8 USP22 USP51 USP11 USP4 USP27X USP15 USP3

2.01e-121445110GO:0070646
GeneOntologyBiologicalProcessprotein modification by small protein conjugation or removal

USP6 USP2 GMCL2 USP8 USP22 USP51 USP11 USP4 USP27X USP15 USP3

2.86e-0510095111GO:0070647
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN1 FBN2

3.59e-054512GO:0035583
GeneOntologyBiologicalProcessregulation of hemopoiesis

FBN1 BRPF1 GPR55 CCL3 CCL3L1 PGLYRP3 CCR6 BRD1

4.95e-05540518GO:1903706
GeneOntologyBiologicalProcesspost-translational protein modification

USP6 USP2 GMCL2 USP8 USP22 USP51 USP11 USP4 USP27X USP15 USP3

5.05e-0510745111GO:0043687
GeneOntologyBiologicalProcessretinal blood vessel morphogenesis

LAMA1 LRP5

8.93e-056512GO:0061304
GeneOntologyBiologicalProcessmaintenance of protein location in extracellular region

FBN1 FBN2

1.66e-048512GO:0071694
GeneOntologyBiologicalProcessregulation of osteoclast differentiation

FBN1 GPR55 CCL3 CCL3L1

1.94e-04116514GO:0045670
GeneOntologyBiologicalProcessretina vasculature morphogenesis in camera-type eye

LAMA1 LRP5

3.25e-0411512GO:0061299
GeneOntologyBiologicalProcesssequestering of extracellular ligand from receptor

FBN1 FBN2

3.25e-0411512GO:0035581
GeneOntologyBiologicalProcessnegative regulation of osteoclast differentiation

FBN1 GPR55 CCL3

4.20e-0459513GO:0045671
GeneOntologyBiologicalProcessextracellular regulation of signal transduction

FBN1 FBN2

4.59e-0413512GO:1900115
GeneOntologyBiologicalProcessextracellular negative regulation of signal transduction

FBN1 FBN2

4.59e-0413512GO:1900116
GeneOntologyBiologicalProcessastrocyte cell migration

CCL3 CCL3L1

4.59e-0413512GO:0043615
GeneOntologyBiologicalProcessnegative regulation of leukocyte differentiation

FBN1 GPR55 CCL3 PGLYRP3

5.28e-04151514GO:1902106
GeneOntologyBiologicalProcessprotein-containing complex localization

USP6 NETO2 NETO1 PCM1 NMD3

6.07e-04278515GO:0031503
GeneOntologyBiologicalProcessregulation of leukocyte differentiation

FBN1 GPR55 CCL3 CCL3L1 PGLYRP3 CCR6

6.38e-04429516GO:1902105
GeneOntologyBiologicalProcessnegative regulation of hemopoiesis

FBN1 GPR55 CCL3 PGLYRP3

6.41e-04159514GO:1903707
GeneOntologyBiologicalProcessosteoclast differentiation

FBN1 GPR55 CCL3 CCL3L1

6.87e-04162514GO:0030316
GeneOntologyBiologicalProcessregulation of myeloid cell differentiation

FBN1 GPR55 CCL3 CCL3L1 BRD1

7.12e-04288515GO:0045637
GeneOntologyCellularComponentMOZ/MORF histone acetyltransferase complex

BRPF1 BRD1

1.17e-047502GO:0070776
GeneOntologyCellularComponentH3 histone acetyltransferase complex

BRPF1 BRD1

1.56e-048502GO:0070775
GeneOntologyCellularComponentmicrofibril

FBN1 FBN2

4.30e-0413502GO:0001527
HumanPhenoAbnormal upper to lower segment ratio

FBN1 FBN2

2.42e-053152HP:0012772
DomainUSP_CS

USP6 USP2 USP8 USP22 USP51 USP11 USP4 USP27X USP15 USP3

1.37e-15665010IPR018200
DomainUSP_1

USP6 USP2 USP8 USP22 USP51 USP11 USP4 USP27X USP15 USP3

2.55e-15705010PS00972
DomainUCH

USP6 USP2 USP8 USP22 USP51 USP11 USP4 USP27X USP15 USP3

2.97e-15715010PF00443
DomainUSP_2

USP6 USP2 USP8 USP22 USP51 USP11 USP4 USP27X USP15 USP3

2.97e-15715010PS00973
DomainUSP_3

USP6 USP2 USP8 USP22 USP51 USP11 USP4 USP27X USP15 USP3

3.44e-15725010PS50235
DomainUSP_dom

USP6 USP2 USP8 USP22 USP51 USP11 USP4 USP27X USP15 USP3

3.44e-15725010IPR028889
DomainPeptidase_C19_UCH

USP6 USP2 USP8 USP22 USP51 USP11 USP4 USP27X USP15 USP3

3.44e-15725010IPR001394
DomainUb_USP-typ

USP11 USP4 USP15

7.21e-084503IPR028135
DomainUbiquitin_3

USP11 USP4 USP15

7.21e-084503PF14836
DomainDUSP

USP11 USP4 USP15

3.59e-076503SM00695
DomainDUSP

USP11 USP4 USP15

3.59e-076503PF06337
Domain-

USP11 USP4 USP15

6.27e-0775033.30.2230.10
DomainPept_C19_DUSP

USP11 USP4 USP15

6.27e-077503IPR006615
DomainDUSP

USP11 USP4 USP15

6.27e-077503PS51283
Domainzf-UBP

USP22 USP51 USP3

6.44e-0614503PF02148
DomainZF_UBP

USP22 USP51 USP3

6.44e-0614503PS50271
DomainZnf_UBP

USP22 USP51 USP3

6.44e-0614503IPR001607
DomainUSP_C

USP11 USP15

2.10e-053502IPR029346
DomainUSP7_C2

USP11 USP15

2.10e-053502PF14533
DomainFBN

FBN1 FBN2

2.10e-053502IPR011398
DomainEGF_1

ITGBL1 FBN1 FBN2 LAMA1 LRP5 MUC12

5.87e-05255506PS00022
DomainEGF_2

ITGBL1 FBN1 FBN2 LAMA1 LRP5 MUC12

7.26e-05265506PS01186
DomainTB

FBN1 FBN2

1.46e-047502PF00683
DomainLDLR_class-A_CS

NETO2 NETO1 LRP5

1.66e-0440503IPR023415
DomainEnhancer_polycomb-like_N

BRPF1 BRD1

1.95e-048502IPR019542
Domain-

FBN1 FBN2

1.95e-0485023.90.290.10
DomainEPL1

BRPF1 BRD1

1.95e-048502PF10513
DomainLdl_recept_a

NETO2 NETO1 LRP5

2.37e-0445503PF00057
DomainTB

FBN1 FBN2

2.50e-049502PS51364
DomainTB_dom

FBN1 FBN2

2.50e-049502IPR017878
Domain-

NETO2 NETO1 LRP5

2.53e-04465034.10.400.10
DomainLDLRA_1

NETO2 NETO1 LRP5

2.87e-0448503PS01209
DomainLDrepeatLR_classA_rpt

NETO2 NETO1 LRP5

3.05e-0449503IPR002172
DomainLDLa

NETO2 NETO1 LRP5

3.05e-0449503SM00192
DomainLDLRA_2

NETO2 NETO1 LRP5

3.05e-0449503PS50068
DomainEGF

ITGBL1 FBN1 FBN2 LAMA1 LRP5

4.04e-04235505SM00181
DomainEGF-like_dom

ITGBL1 FBN1 FBN2 LAMA1 LRP5

5.25e-04249505IPR000742
DomainEGF-like_CS

FBN1 FBN2 LAMA1 LRP5 MUC12

6.50e-04261505IPR013032
DomainPWWP

BRPF1 BRD1

1.29e-0320502SM00293
DomainEPHD

BRPF1 BRD1

1.57e-0322502PS51805
DomainPWWP

BRPF1 BRD1

1.71e-0323502PF00855
DomainPWWP_dom

BRPF1 BRD1

1.71e-0323502IPR000313
DomainPWWP

BRPF1 BRD1

1.87e-0324502PS50812
DomaincEGF

FBN1 FBN2

2.19e-0326502IPR026823
DomaincEGF

FBN1 FBN2

2.19e-0326502PF12662
DomainBromodomain_CS

BRPF1 BRD1

2.19e-0326502IPR018359
DomainEGF_CA

FBN1 FBN2 LRP5

2.36e-0399503PS01187
DomainBROMODOMAIN_1

BRPF1 BRD1

4.41e-0337502PS00633
DomainEGF-like_Ca-bd_dom

FBN1 FBN2 LRP5

4.46e-03124503IPR001881
DomainBromodomain

BRPF1 BRD1

4.64e-0338502PF00439
DomainBROMODOMAIN_2

BRPF1 BRD1

5.39e-0341502PS50014
DomainBROMO

BRPF1 BRD1

5.65e-0342502SM00297
DomainBromodomain

BRPF1 BRD1

5.65e-0342502IPR001487
Domain-

BRPF1 BRD1

5.65e-03425021.20.920.10
DomainLamG

COL15A1 LAMA1

6.18e-0344502SM00282
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

USP2 USP8 USP22 USP11 USP4 USP15 USP3

5.48e-07191377MM15289
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

USP2 USP8 USP22 USP11 USP4 USP15 USP3

1.46e-06221377M27578
PathwayREACTOME_DEUBIQUITINATION

USP2 USP8 USP22 USP11 USP4 USP15 USP3

4.52e-06262377MM15286
PathwayREACTOME_DEUBIQUITINATION

USP2 USP8 USP22 USP11 USP4 USP15 USP3

1.07e-05299377M27574
PathwayREACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES

CCL3 CCL3L1 CCR6

4.65e-0458373MM14978
Pubmed

Human and mouse proteases: a comparative genomic approach.

USP6 USP2 USP8 USP22 USP51 USP11 USP4 USP27X USP15 USP3

3.12e-1781511012838346
Pubmed

Deubiquitinating enzymes: a new class of biological regulators.

USP6 USP2 USP8 USP11 USP4 USP15

3.63e-14155169827704
Pubmed

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.

USP6 USP2 USP8 USP22 USP11 USP4 USP27X USP15 USP3

8.79e-1314751929576527
Pubmed

Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes.

USP2 USP8 USP11 USP4 USP15 USP3

5.15e-106451633141564
Pubmed

A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate.

USP2 USP8 USP51 USP4 USP15

2.02e-093651522626734
Pubmed

Structural variability of the ubiquitin specific protease DUSP-UBL double domains.

USP11 USP4 USP15

2.97e-09351322001210
Pubmed

Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11.

USP11 USP4 USP15

2.97e-09351326503449
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

USP6 USP2 USP8 USP22 USP11 USP4 ALDH9A1 USP27X USP15 USP3 ZMYM4 NMD3

1.79e-081005511219615732
Pubmed

Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.

USP2 USP8 USP4 USP15

8.18e-082851422118674
Pubmed

Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin.

USP2 USP11 USP4 USP15

1.63e-073351430323974
Pubmed

USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor.

USP11 USP4 USP15

1.65e-07851322706160
Pubmed

USP11 Is a Negative Regulator to γH2AX Ubiquitylation by RNF8/RNF168.

USP2 USP8 USP11

1.65e-07851326507658
Pubmed

The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types.

USP8 USP11 USP4

2.48e-07951322195557
Pubmed

USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA.

USP2 USP22 USP3

6.47e-071251327801882
Pubmed

Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5.

CCL3 CCL3L1 CCR6

1.33e-06155139139699
Pubmed

Ubiquitin Specific Peptidase 15 (USP15) suppresses glioblastoma cell growth via stabilization of HECTD1 E3 ligase attenuating WNT pathway activity.

USP11 USP4 USP15

1.99e-061751329299163
Pubmed

Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.

FBN1 FBN2

2.11e-06251212399449
Pubmed

A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain.

NETO2 NETO1

2.11e-06251211943477
Pubmed

Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.

FBN1 FBN2

2.11e-06251221851253
Pubmed

Responsiveness to DDAVP in Cushing's disease is associated with USP8 mutations through enhancing AVPR1B promoter activity.

USP8 AVPR1B

2.11e-06251235451730
Pubmed

Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.

FBN1 FBN2

2.11e-06251212429739
Pubmed

Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.

FBN1 FBN2

2.11e-06251224833718
Pubmed

New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.

FBN1 FBN2

2.11e-06251230044367
Pubmed

Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.

FBN1 FBN2

2.11e-06251221440062
Pubmed

MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.

FBN1 FBN2

2.11e-06251215131124
Pubmed

Neto auxiliary protein interactions regulate kainate and NMDA receptor subunit localization at mossy fiber-CA3 pyramidal cell synapses.

NETO2 NETO1

2.11e-06251224403160
Pubmed

Expression of Btcl2, a novel member of Btcl gene family, during development of the central nervous system.

NETO2 NETO1

2.11e-06251215464227
Pubmed

NETO1 Guides Development of Glutamatergic Connectivity in the Hippocampus by Regulating Axonal Kainate Receptors.

NETO2 NETO1

2.11e-06251228680963
Pubmed

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

FBN1 FBN2

2.11e-06251224265020
Pubmed

Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.

FBN1 FBN2

2.11e-06251212524050
Pubmed

In vivo studies of mutant fibrillin-1 microfibrils.

FBN1 FBN2

2.11e-06251220529844
Pubmed

Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.

FBN1 FBN2

2.11e-06251225524144
Pubmed

Microfibril structure masks fibrillin-2 in postnatal tissues.

FBN1 FBN2

2.11e-06251220404337
Pubmed

Molecular insights into the recognition of N-terminal histone modifications by the BRPF1 bromodomain.

BRPF1 BRD1

2.11e-06251224333487
Pubmed

Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.

FBN1 FBN2

2.11e-06251223133647
Pubmed

Fibrillln mutations in Marfan syndrome and related phenotypes.

FBN1 FBN2

2.11e-0625128791520
Pubmed

Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.

FBN1 FBN2

2.11e-0625128120105
Pubmed

The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.

FBN1 FBN2

2.11e-06251235419902
Pubmed

Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.

FBN1 FBN2

2.11e-0625128307578
Pubmed

Fibrillins 1 and 2 perform partially overlapping functions during aortic development.

FBN1 FBN2

2.11e-06251216407178
Pubmed

Isolation and characterization of the mouse ubiquitin-specific protease Usp15.

USP11 USP15

2.11e-06251212532266
Pubmed

Fibrillin assembly: dimer formation mediated by amino-terminal sequences.

FBN1 FBN2

2.11e-06251210504303
Pubmed

Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.

FBN1 FBN2

2.11e-0625121852206
Pubmed

N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.

FBN1 FBN2

2.11e-06251210359653
Pubmed

Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.

FBN1 FBN2

2.11e-0625127744963
Pubmed

Identification of new variants within the two functional genes CCL3 and CCL3L encoding the CCL3 (MIP-1alpha) chemokine: implications for HIV-1 infection.

CCL3 CCL3L1

2.11e-06251219055602
Pubmed

NETO1 Regulates Postsynaptic Kainate Receptors in CA3 Interneurons During Circuit Maturation.

NETO2 NETO1

2.11e-06251231044365
Pubmed

Kainate receptor auxiliary subunit NETO2 is required for normal fear expression and extinction.

NETO2 NETO1

2.11e-06251230770891
Pubmed

Fibrillin microfibrils in bone physiology.

FBN1 FBN2

2.11e-06251226408953
Pubmed

Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.

FBN1 FBN2

2.11e-06251218006876
Pubmed

Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS.

USP2 USP22 USP4

2.39e-061851330410068
Pubmed

ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.

FBN1 FBN2 LAMA1

2.39e-061851339040056
Pubmed

USP37 is a SNAI1 deubiquitinase.

USP2 USP11 USP3

5.88e-062451331911859
Pubmed

Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.

FBN1 FBN2

6.32e-06351210825173
Pubmed

Proteolysis of macrophage inflammatory protein-1alpha isoforms LD78beta and LD78alpha by neutrophil-derived serine proteases.

CCL3 CCL3L1

6.32e-06351215728180
Pubmed

Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1.

BRPF1 BRD1

6.32e-06351220400950
Pubmed

Phosphorylation of USP15 and USP4 Regulates Localization and Spliceosomal Deubiquitination.

USP4 USP15

6.32e-06351231330151
Pubmed

Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1.

NETO2 NETO1

6.32e-06351226720915
Pubmed

piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination.

USP8 MUC12

6.32e-06351237332045
Pubmed

Three human homologs of a murine gene encoding an inhibitor of stem cell proliferation.

CCL3 CCL3L1

6.32e-0635122271120
Pubmed

Neto2 Assembles with Kainate Receptors in DRG Neurons during Development and Modulates Neurite Outgrowth in Adult Sensory Neurons.

NETO2 NETO1

6.32e-06351228235897
Pubmed

Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.

FBN1 FBN2

6.32e-06351230201140
Pubmed

Structures of human genes coding for cytokine LD78 and their expression.

CCL3 CCL3L1

6.32e-0635121694014
Pubmed

Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.

FBN1 FBN2

6.32e-06351220855508
Pubmed

Adamts18 modulates the development of the aortic arch and common carotid artery.

FBN1 FBN2 LAMA1

7.54e-062651334189436
Pubmed

Lack of chemokine (C-C motif) ligand 3 leads to decreased survival and reduced immune response after bacterial meningitis.

CCL3 CCL3L1

1.26e-05451230199766
Pubmed

Leukemia cell infiltration causes defective erythropoiesis partially through MIP-1α/CCL3.

CCL3 CCL3L1

1.26e-05451227109512
Pubmed

Identification and characterization of an inhibitor of haemopoietic stem cell proliferation.

CCL3 CCL3L1

1.26e-0545122320111
Pubmed

Macrophage inflammatory protein-1alpha mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1beta up-regulation.

CCL3 CCL3L1

1.26e-05451220223588
Pubmed

The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors.

NETO2 NETO1

1.26e-05451226277340
Pubmed

Requirement of MIP-1 alpha for an inflammatory response to viral infection.

CCL3 CCL3L1

1.26e-0545127667639
Pubmed

The chemokine CCL3 promotes experimental liver fibrosis in mice.

CCL3 CCL3L1

1.26e-05451223799074
Pubmed

Role of macrophage inflammatory protein-1alpha in T-cell-mediated immunity to viral infection.

CCL3 CCL3L1

1.26e-05451214581577
Pubmed

Sequence of the murine haemopoietic stem cell inhibitor/macrophage inflammatory protein 1 alpha gene.

CCL3 CCL3L1

1.26e-0545122216738
Pubmed

Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.

FBN1 FBN2

1.26e-05451212429738
Pubmed

Potential role of the chemokine macrophage inflammatory protein 1alpha in human and experimental schistosomiasis.

CCL3 CCL3L1

1.26e-05451215784598
Pubmed

Absence of macrophage inflammatory protein-1{alpha} does not impact macrophage accumulation in adipose tissue of diet-induced obese mice.

CCL3 CCL3L1

1.26e-05451220551286
Pubmed

Exposure to mechanical ventilation promotes tolerance to ventilator-induced lung injury by Ccl3 downregulation.

CCL3 CCL3L1

1.26e-05451226472813
Pubmed

CpG domains downstream of TSSs promote high levels of gene expression.

CCL3 CCL3L1

1.26e-05451224413563
Pubmed

Contribution of the sympathetic nervous system on the burn-associated impairment of CCL3 production.

CCL3 CCL3L1

1.26e-05451215760677
Pubmed

Dual fluorescence reporter mice for Ccl3 transcription, translation, and intercellular communication.

CCL3 CCL3L1

1.26e-05451238661718
Pubmed

The Chemokine CCL3 Regulates Myeloid Differentiation and Hematopoietic Stem Cell Numbers.

CCL3 CCL3L1

1.26e-05451230279500
Pubmed

Expression and regulation of macrophage inflammatory protein-1 alpha by murine alveolar and peritoneal macrophages.

CCL3 CCL3L1

1.26e-0545128292385
Pubmed

Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model.

CCL3 CCL3L1

1.26e-05451216009684
Pubmed

Type 1 T-cell responses in chlamydial lung infections are associated with local MIP-1alpha response.

CCL3 CCL3L1

1.26e-05451220622889
Pubmed

Molecular cloning and posttranscriptional regulation of macrophage inflammatory protein-1 alpha in alveolar macrophages.

CCL3 CCL3L1

1.26e-0545127779098
Pubmed

Ccl3 enhances docetaxel chemosensitivity in breast cancer by triggering proinflammatory macrophage polarization.

CCL3 CCL3L1

1.26e-05451235613826
Pubmed

Regulatory T cells were recruited by CCL3 to promote cryo-injured muscle repair.

CCL3 CCL3L1

1.26e-05451230321562
Pubmed

CCL3 aggravates intestinal damage in NEC by promoting macrophage chemotaxis and M1 macrophage polarization.

CCL3 CCL3L1

1.26e-05451236550354
Pubmed

Neutrophil-derived CCL3 is essential for the rapid recruitment of dendritic cells to the site of Leishmania major inoculation in resistant mice.

CCL3 CCL3L1

1.26e-05451220140197
Pubmed

Human eye development is characterized by coordinated expression of fibrillin isoforms.

FBN1 FBN2

1.26e-05451225406291
Pubmed

The CCL3/macrophage inflammatory protein-1alpha-binding protein evasin-1 protects from graft-versus-host disease but does not modify graft-versus-leukemia in mice.

CCL3 CCL3L1

1.26e-05451220100934
Pubmed

The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory.

CCL3 CCL3L1

1.26e-05451226511387
Pubmed

ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.

USP51 USP27X

1.26e-05451227132940
Pubmed

Development and pathology of Fasciola hepatica in CCL3-deficient mice.

CCL3 CCL3L1

1.26e-05451220643506
Pubmed

An increase in the susceptibility of burned patients to infectious complications due to impaired production of macrophage inflammatory protein 1 alpha.

CCL3 CCL3L1

1.26e-05451212370381
Pubmed

MIP-1alpha as a critical macrophage chemoattractant in murine wound repair.

CCL3 CCL3L1

1.26e-0545129541500
Pubmed

The chemokine MIP1alpha/CCL3 determines pathology in primary RSV infection by regulating the balance of T cell populations in the murine lung.

CCL3 CCL3L1

1.26e-05451220195359
Pubmed

Acceleration of idiopathic pneumonia syndrome (IPS) in the absence of donor MIP-1 alpha (CCL3) after allogeneic BMT in mice.

CCL3 CCL3L1

1.26e-05451212511416
Pubmed

Otitis Media and Nasopharyngeal Colonization in ccl3-/- Mice.

CCL3 CCL3L1

1.26e-05451228847849
InteractionATXN7L3 interactions

USP6 USP22 USP51 USP11 USP27X

2.22e-0753515int:ATXN7L3
InteractionUSP28 interactions

USP8 USP51 USO1 USP4 USP15 PCM1

3.99e-07113516int:USP28
InteractionRNF19B interactions

USP22 USP4 USP15 NEK9 ZMYM4

2.12e-0683515int:RNF19B
InteractionPLA2G2A interactions

USP2 USP8 USP4 USP15

2.52e-0638514int:PLA2G2A
InteractionUSP51 interactions

USP22 USP51 USP27X USP15

4.17e-0643514int:USP51
InteractionTCEAL2 interactions

USP11 USP4 USP15

2.98e-0524513int:TCEAL2
InteractionUSP21 interactions

USP2 USP8 USP51 USP4 USP15

5.34e-05161515int:USP21
InteractionSUPT20H interactions

USP22 USP51 USP4 USP27X

6.93e-0587514int:SUPT20H
InteractionLTBP1 interactions

FBN1 FBN2 PCDHGA7 CCL3

8.62e-0592514int:LTBP1
InteractionUSP27X interactions

USP22 USP51 USP27X

1.12e-0437513int:USP27X
InteractionMUC12 interactions

USP8 MUC12

1.31e-047512int:MUC12
InteractionTAF5L interactions

USP22 USP51 CCL3 USP27X

1.55e-04107514int:TAF5L
InteractionATXN7 interactions

FBN1 USP22 USP51 USP27X

1.66e-04109514int:ATXN7
Cytoband14q24.3

MLH3 NEK9

4.85e-039351214q24.3
CytobandXp11.23

USP11 USP27X

5.06e-0395512Xp11.23
Cytoband17q12

HEATR9 CCL3

5.48e-039951217q12
GeneFamilyUbiquitin specific peptidases

USP6 USP2 USP8 USP22 USP51 USP11 USP4 USP27X USP15 USP3

6.01e-18563510366
GeneFamilyPWWP domain containing

BRPF1 BRD1

8.21e-04223521147
GeneFamilyChemokine ligands|Endogenous ligands

CCL3 CCL3L1

3.42e-0345352483
GeneFamilyG protein-coupled receptors, Class A orphans

GPR26 GPR55

9.97e-0378352262
GeneFamilyPHD finger proteins

BRPF1 BRD1

1.31e-029035288
CoexpressionWATANABE_ULCERATIVE_COLITIS_WITH_CANCER_UP

FBN1 LRP5 MN1

6.58e-0619513M12084
ToppCellCV-Severe-7|CV / Virus stimulation, Condition and Cluster

MLH3 CCL3 CCL3L1 NFAT5 PCM1

1.76e-061765153de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCellCV-Severe-7|Severe / Virus stimulation, Condition and Cluster

MLH3 CCL3L1 NFAT5 PCM1

5.01e-0517751482fdd6185b368f54f03de389427cbe3071d21a99
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 COL15A1 MN1

5.12e-0517851427497dbfcf9bb4dd0bf7caa0bd78c7e85f5c18ee
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 COL15A1 MN1

5.12e-05178514d348a9550db940d204706529759dc51e30506b5f
ToppCellP28-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ITGBL1 FBN1 COL15A1 MN1

5.35e-051805149adebde5f4ca6dcb90e9113622862e14298465ac
ToppCellmetastatic_Brain-Fibroblasts-Myofibroblasts|metastatic_Brain / Location, Cell class and cell subclass

ITGBL1 FBN1 FBN2 NETO1

5.46e-05181514bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 FBN2 COL15A1

5.95e-05185514785c55d39909fac74415f24427979691e7e694e6
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 FBN2 COL15A1

5.95e-0518551497a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 FBN2 COL15A1

6.07e-0518651494d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 FBN2 COL15A1

6.20e-051875144e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 FBN2 COL15A1

6.20e-05187514d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 FBN2 COL15A1

6.20e-05187514827eae63fabf6892a82ce7779b5f395958d3d628
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGBL1 FBN1 COL15A1 MN1

6.33e-051885146c6486cae9a8f2f8200598cb4bfd3fd513eb28a3
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGBL1 FBN1 COL15A1 MN1

6.33e-05188514bba6b273bd47dd0e27fde914e9e6fc9d76fd5176
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 COL15A1 MN1

6.46e-05189514378f26f751ab4b470948c35dd8347de72dd12ff7
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 COL15A1 MN1

6.46e-05189514f0a2d4ef9896d764971ebbc6952510c128bb76e8
ToppCellCOVID-19_Mild-Treg|COVID-19_Mild / Disease condition and Cell class

GPR55 CCR6 PLCL1 USP15

6.46e-05189514f0fceb5f87ca260bfe038c0db3487a6d2e1b0a6e
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGBL1 FBN1 FBN2 MN1

6.59e-05190514947807863a9b247c301c6cf63d6fd5a2c8018e66
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGBL1 FBN1 FBN2 MN1

6.73e-05191514db4943dd19207663fb9e27f8940fa4b06a933625
ToppCellCOPD-Lymphoid-T_Regulatory|Lymphoid / Disease state, Lineage and Cell class

NETO2 CCR6 PLCL1 USP15

6.73e-051915143ae18bc4e3dff49b5d5958da8ebc3f747274b69c
ToppCellCOVID-19_Severe-Treg|COVID-19_Severe / Disease condition and Cell class

GPR55 CCR6 PLCL1 USP15

6.73e-0519151406fdd76ea13b93e29959c745698b57af6746aaeb
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 FBN1 ADGRG2 MN1

6.73e-051915142c51850f5c559d665b8a27a12b75af9ed58dffe1
ToppCellCOVID-19-kidney-Myeloid|kidney / Disease (COVID-19 only), tissue and cell type

ATP6V1B2 CCL3 CCL3L1 USP15

6.87e-05192514441cd1ec171f643b28e1f6f9c04def629cc7391b
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGBL1 FBN1 COL15A1 MN1

6.87e-0519251432acd89617934016cd135d2cc797e8e79ae1b37f
ToppCelldroplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGBL1 FBN1 COL15A1 MN1

6.87e-05192514c3707243c5590d852c9f28429c96f50a1fa6b0dc
ToppCellfacs-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 COL15A1 MN1

6.87e-05192514a2c31390da4962bda9a936470b0b68fa1f5d47d1
ToppCelldroplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGBL1 FBN1 COL15A1 MN1

6.87e-05192514f9fb24457999dc9e751a099d7f995543b9330ad4
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGBL1 FBN1 COL15A1 MN1

6.87e-051925140e7e55505bd5454d7cf952a63fdcb46ec76f1973
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGBL1 FBN1 COL15A1 MN1

6.87e-051925147b48df661f61ce494bf6f0b9a74b0422e29c24bf
ToppCellfacs-Lung-nan-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 COL15A1 MN1

6.87e-05192514eeab1cef7c36ae824381952c5b2c982368c379fd
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

PLCL1 USP15 USP3 PCM1

6.87e-0519251447646d7e4990be85072987f92bf18d52f8da752e
ToppCellCOVID-19-kidney-Myeloid|COVID-19 / Disease (COVID-19 only), tissue and cell type

ATP6V1B2 CCL3L1 USP15 USP3

6.87e-051925140b9d22a222f1201e375f8e55cace9ef939febae4
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGBL1 FBN1 COL15A1 MN1

7.01e-05193514025836c5c5a711e477c326559e618e47cae42d11
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 COL15A1 ADGRG2

7.01e-051935140a665531d581d4e3941e29d3f95569da8f166447
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 FBN1 COL15A1 NETO1

7.01e-05193514dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 COL15A1 MN1

7.01e-05193514858a186804b36d45957238d3d3eed2768b961641
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 COL15A1 ADGRG2

7.01e-0519351424ce1f37cca655415410d2403a52d1ebb3332280
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 FBN1 COL15A1 MN1

7.01e-051935147865e7ec0a288249540d4cba94ae01c93e1b617c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 FBN1 COL15A1 NETO1

7.01e-05193514e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCelldroplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGBL1 FBN1 COL15A1 MN1

7.15e-051945145594f7437448cb4b37d2d100f44d30c4a367df26
ToppCellmoderate-Epithelial-FOXN4+|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NETO2 SANBR MUC12 PCM1

7.15e-051945145dffa578149104dda33774361e9e77b227b5f1ce
ToppCellmoderate-Epithelial-FOXN4+|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NETO2 SANBR MUC12 PCM1

7.15e-05194514dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCell18-Distal-Mesenchymal-Mesenchyme_SERPINF1-high|Distal / Age, Tissue, Lineage and Cell class

ITGBL1 FBN1 FBN2 COL15A1

7.29e-05195514f86737bff21d81673238813df61a15cfe88d0b15
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGBL1 FBN1 COL15A1 MN1

7.29e-05195514773728703bc8969bff0e1de58fe3e1631add0a0a
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 FBN1 COL15A1 NETO1

7.58e-051975144cf4e9553397cd8dee883dbec24f41bec41aff99
ToppCell(2)_Fibroblasts-(24)_Fibro-5|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis

USP2 ITGBL1 FBN1 COL15A1

7.58e-0519751483a4b79fbfa1cf63441dee4424c3b87c988287bf
ToppCell(2)_Fibroblasts-(24)_Fibro-5|World / Cell class and subclass of bone marrow stroma cells in homeostatis

USP2 ITGBL1 COL15A1 MN1

7.89e-051995146c0354f57883330c685a8d9d5d3014ace7eca584
ToppCelllymphoid-NK_cell-NK_cell|NK_cell / Lineage, cell class and subclass

USP22 CCL3 BRD1 USP3

7.89e-05199514945fbf5845403a8b22d04963f50ad69c414b6153
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ITGBL1 FBN1 COL15A1 PLCL1

8.04e-0520051458b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

LRP5 CCL3 CCR6

1.76e-04955133d6b97576ce4e7a3e495cbc7246ea8c0b2a386f7
ToppCellCOVID-19_Convalescent-Classical_Monocyte-cMono_1|Classical_Monocyte / Disease condition and Cell class

CCL3 CCL3L1

2.36e-0420512f245d0c009d45a3bd18cd970d82f10da2936c9f5
ToppCellStriatum-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Striatum / BrainAtlas - Mouse McCarroll V32

FBN2 COL15A1 LAMA1

2.65e-04109513f4b9fe5335cabe48a5fae7ec51bab0d7bdb17321
ToppCellStriatum-Endothelial-ENDOTHELIAL_TIP|Striatum / BrainAtlas - Mouse McCarroll V32

FBN2 COL15A1 LAMA1

2.65e-04109513a84a4a3ac19692e5595b9820d49e12ae336f4bbf
ToppCellStriatum-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)-|Striatum / BrainAtlas - Mouse McCarroll V32

FBN2 COL15A1 LAMA1

2.65e-04109513f7d7b67f7585f2ae0ac905bcf3980264cf9234b8
ToppCellStriatum-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Striatum / BrainAtlas - Mouse McCarroll V32

FBN2 COL15A1 LAMA1

2.65e-04109513f007fa3dc92d6c8543585e47ccec218263b3266e
ToppCellStriatum-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)|Striatum / BrainAtlas - Mouse McCarroll V32

FBN2 COL15A1 LAMA1

2.65e-041095138460683529759585bd363d10a16ee13af2bd4e28
ToppCellCOVID-19_Convalescent-Classical_Monocyte-cMono_1|COVID-19_Convalescent / Disease condition and Cell class

CCL3 CCL3L1

3.72e-042551200e8c78c4fcc961eb37ea5838f4203ae32cf7faa
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast-FB-2|PND01-03-samps / Age Group, Lineage, Cell class and subclass

NETO1 C1orf105 GPR55

3.96e-041255136cd741dd1c7ee6b16437cca7c15c99b5c95603fc
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ITGBL1 COL15A1 LAMA1

4.05e-04126513f1f24b06d301c266226d1a59dd28585f5ac68f29
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ITGBL1 COL15A1 LAMA1

4.05e-04126513fe6900eb37e4f09465a1276586c73dd38545fa2a
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ITGBL1 COL15A1 LAMA1

4.05e-041265131ac4cc747e466bc79e33b97608b19ad29a7a6a41
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ITGBL1 COL15A1 LAMA1

4.05e-041265132de551d7a8765afec1da8852727c79fec90f45f8
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_TIP|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ITGBL1 COL15A1 LAMA1

4.05e-041265133d507f829882d043f633db2612b76936e2042445
ToppCellControl-Classical_Monocyte-|Control / Disease condition and Cell class

GPR55 CCL3 CCL3L1

4.44e-04130513e55f522dab5a6c3af30ad87ac8b32166f660c314
ToppCellControl-Classical_Monocyte-|Classical_Monocyte / Disease condition and Cell class

GPR55 CCL3 CCL3L1

4.44e-041305134433b40b099845f113993b6ecf85ec594b4b9219
ToppCellCerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Cerebellum / BrainAtlas - Mouse McCarroll V32

FBN2 COL15A1 LAMA1

4.85e-04134513d29ac8152dc581c0da2430d06cd259ac0eded808
ToppCellCerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Cerebellum / BrainAtlas - Mouse McCarroll V32

FBN2 COL15A1 LAMA1

4.85e-04134513459c39df15d3cf9144ce7827e8d14830d31353bb
ToppCellCerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Apod_(Apod)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

FBN2 COL15A1 LAMA1

4.85e-04134513d065449ca3679e4818b74fb7302cc7f1ce62f691
ToppCellCerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Apod_(Apod)|Cerebellum / BrainAtlas - Mouse McCarroll V32

FBN2 COL15A1 LAMA1

4.85e-041345130be389f416818a22e80098dd809fdf45b14171e8
ToppCellSmart-seq2-blood_(Smart-seq2)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_cytokine_secreting_effector_T_cell|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HEATR9 GPR55 MUC12

5.39e-04139513a542ef99ba57f364ea9707b3119e11f5a240034c
ToppCellfacs-Heart-Unknown-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR26 NETO2 LAMA1

5.62e-041415134aa4b3476dc5abefbd348353cfe711cd5fe3d52f
ToppCellfacs-Heart-Unknown-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR26 NETO2 LAMA1

5.62e-04141513e40c6f1b7fbaa46b3eaa55f1b37ef360b04370a8
ToppCellfacs-Heart-Unknown-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR26 NETO2 LAMA1

5.74e-04142513759fbbd15b4fb313bd6269b7f087edafebd530ef
ToppCellLPS-IL1RA-Myeloid-Monocytes,_Macrophages-Erythroid|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ITGBL1 USP27X MN1

5.97e-041445137c471e332f87d60f4dbed01f3e66bf39995218d0
ToppCellPBMC-Severe-cDC_8|Severe / Compartment, Disease Groups and Clusters

CCL3 CCL3L1 PLCL1

6.10e-0414551323a9a4fd1934c4a38d9259105c1fdbac459575cb
ToppCellCerebellum-Endothelial-ENDOTHELIAL_TIP|Cerebellum / BrainAtlas - Mouse McCarroll V32

FBN2 COL15A1 LAMA1

6.60e-041495133980fa4f1986a2f164a1826ea043fb71f1d756cd
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FBN2 CCL3 CCL3L1

7.12e-041535135fbb90b8477f9fdabf3be19efd3068fbf70abee6
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

USP2 LAMA1 PLCL1

7.12e-041535130307f10e772021ae68a42690634df458672a6df9
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

FBN2 CCL3 CCL3L1

7.12e-041535132c46183481e6d5a7fa190a743062509465f88e56
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

FBN2 CCL3 CCL3L1

7.12e-04153513decc4f3098a9374a6b65c015a9d36380986290bf
ToppCellPBMC-Control-cDC_8|Control / Compartment, Disease Groups and Clusters

LRP5 CCL3L1 ZNF513

7.12e-04153513db1a6914f2033fb0748e0523cffe5d6dc4e901be
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FBN2 CCL3 CCL3L1

7.12e-0415351336a28805c0545c2f410c74a6ca0a70d840e75715
ToppCell5'-Adult-Appendix-Hematopoietic-T_cells-gdT|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HEATR9 GPR55 USP27X

7.26e-04154513d2aa24c593a1c0c6f186b74a18438b64b4e59701
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ITGBL1 COL15A1 LAMA1

7.26e-0415451365dbb60f636562eeba3dafadae9c0c7db2b27476
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP51 CLPS NFAT5

7.40e-04155513441fcb6d05364fc6f4973f0b973f1a80b573ce1f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL15A1 USP27X MN1

7.54e-04156513ea9223bb6450b22df11efa1705ab72dab005244a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL15A1 USP27X MN1

7.54e-04156513586b5509074c4cc359e9e31a968c2ded71c994ca
ToppCellfacs-MAT-Fat-18m-Lymphocytic-NK_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP51 HEATR9 CCL3

7.68e-04157513e6846ffd1bb18bf0469bc6d49ab6cf3533d9cde6
ToppCellSmart-seq2-spleen_(Smart-seq2)-lymphocytic-T_lymphocytic-mature_NK_T_cell|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HEATR9 CCL3 CCL3L1

7.68e-041575133aa12913410925d577205cb6f1f5ae6bea20d93f
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ATP6V1B2 CCL3 CCL3L1

7.96e-041595136c0ef40f64d2e35eaae3d0002e3c1f22d1239736
ToppCellHealthy/Control-Treg|Healthy/Control / Disease group and Cell class

ADGRG2 GPR55 PLCL1

7.96e-0415951316a322760c99f3e2c3b73cbb399f77868951d3cb
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

USP51 SANBR NEK9

7.96e-041595131472536eea61d4f13033efe42f128bae1614fa74
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ATP6V1B2 CCL3 CCL3L1

7.96e-04159513745a59c33b04620c5329bdd50e74a8e611f2dc55
ToppCellHealthy/Control-Treg|World / Disease group and Cell class

ADGRG2 GPR55 PLCL1

8.26e-04161513457297cda5c9cee3bcc069fdecbbe24def027e5f
ToppCellVE-mono3|VE / Condition, Cell_class and T cell subcluster

USP6 CCL3 CCL3L1

8.26e-041615137df3fefc55ab43b897fc78d1f0c7383b10ac33d5
ToppCellVE-mono3-|VE / Condition, Cell_class and T cell subcluster

USP6 CCL3 CCL3L1

8.26e-041615134e45bf7eceb0ee30dec4d8852778366776ea5a8f
ToppCellBAL-Mild-cDC_5|Mild / Compartment, Disease Groups and Clusters

FBN1 CCL3 CCL3L1

8.26e-041615137a6e8ed0b5d999efce8945d8083ab01d71be9a92
ToppCellMild_COVID-19-Myeloid-MoAM2|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

FBN2 CCL3 CCL3L1

8.41e-04162513e5fc80ab19d513af6a7e677a5e67bfebca2e963b
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZNF592 HEATR9 GPR55

8.41e-04162513ca30d9bf61f4133566fdc91c7996e130ea554d01
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRP5 PLCL1 BRD1

8.41e-0416251380317c4253bf8e897782e562f29835f181c65b98
Diseaseglioblastoma (implicated_via_orthology)

USP22 USP51 USP27X

3.59e-079493DOID:3068 (implicated_via_orthology)
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN2

8.10e-063492DOID:65 (implicated_via_orthology)
Diseasescoliosis (is_implicated_in)

FBN1 FBN2

1.62e-054492DOID:0060249 (is_implicated_in)
DiseaseChagas disease (biomarker_via_orthology)

CCL3 CCL3L1

4.04e-056492DOID:12140 (biomarker_via_orthology)
Diseasecrescentic glomerulonephritis (biomarker_via_orthology)

CCL3 CCL3L1

7.52e-058492DOID:13139 (biomarker_via_orthology)
Diseaseanterior uveitis (biomarker_via_orthology)

CCL3 CCL3L1

9.65e-059492DOID:1407 (biomarker_via_orthology)
Diseasenephritis (biomarker_via_orthology)

CCL3 CCL3L1

1.47e-0411492DOID:10952 (biomarker_via_orthology)
Diseaserenal fibrosis (biomarker_via_orthology)

CCL3 CCL3L1

1.76e-0412492DOID:0050855 (biomarker_via_orthology)
Disease

CCL3 CCL3L1

3.19e-0416492609423
DiseaseSusceptibility to HIV infection

CCL3 CCL3L1

3.19e-0416492cv:C1836230
Diseasebipolar disorder (is_implicated_in)

AVPR1B BRD1

1.07e-0329492DOID:3312 (is_implicated_in)
Diseasecysteine-rich with EGF-like domain protein 1 measurement

BRPF1 BRD1

1.30e-0332492EFO_0021870
DiseaseMitral valve prolapse

ZNF592 MN1

1.64e-0336492HP_0001634
Diseaseascending aortic diameter

FBN1 FBN2 USP15

1.64e-03140493EFO_0021787

Protein segments in the cluster

PeptideGeneStartEntry
QNSNVILFCDMCNLA

BRD1

226

O95696
ALMANFLTQGQVCCN

ALDH9A1

276

P49189
NCTFTIKLNNTMNAC

ADGRG2

186

Q8IZP9
AINFNCGMLLLTCIS

CCR6

126

P51684
SNMCINNTLVCNGLQ

NETO1

301

Q8TDF5
CAQSARCLVNFNILM

PCDHGA7

96

Q9Y5G6
CGLNEFNKLGLNQCM

NEK9

556

Q8TD19
CMHNNGQCGQLCLAI

LRP5

906

O75197
LNLTCGNLLCTVVNM

GPR26

46

Q8NDV2
ICQTLMQDQQTLSCL

PCM1

1016

Q15154
LCSVLTQDFCMLFNN

MLH3

911

Q9UHC1
QCQQQSVCSQMLRGL

PGLYRP3

56

Q96LB9
INLENGELCMNSAQC

CLPS

26

P04118
CQTMLLIQLPFCGNN

OR6X1

156

Q8NH79
QLSMCFSNVNCCLDV

GPR55

271

Q9Y2T6
MFLFGIQNNCSQLLT

NFAT5

1446

O94916
CFTVISNQMCQGQLS

FBN1

186

P35555
AALAVLLCTMALCNQ

CCL3

6

P10147
CFTQVNNQMCQGQLT

FBN2

216

P35556
NNGQCWCLLMLLSVS

COL15A1

6

P39059
QMCKNSQDIICSNAG

ITGBL1

141

O95965
GQSCLAALSTACQNM

MN1

821

Q10571
NGSMDNVCLFLNLAN

ATP6V1B2

251

P21281
SSCQKAMFQCGLLQQ

USO1

301

O60763
AMFQCGLLQQLCTIL

USO1

306

O60763
SMGCAFINLCILASQ

TMEM205

61

Q6UW68
CINCLQNTMGINCET

LAMA1

361

P25391
AAACMLQLDGLIQQC

GMCL2

186

Q8NEA9
SNMCINNSLVCNGVQ

NETO2

306

Q8NC67
TPCNMNCINANLLTR

SANBR

261

Q6NSI8
NSNVILFCDMCNLAV

BRPF1

286

P55201
QCDSMLLRNQQLCST

C1orf105

71

O95561
AALAVLLCTMALCNQ

CCL3L1

6

P16619
CSLCNYSCNQSMNLK

ZNF513

446

Q8N8E2
NMKQIQLACLSCGLS

PLCL1

1051

Q15111
INLGNTCFMNCIVQA

USP51

366

Q70EK9
INLGNTCFMNCIVQA

USP27X

81

A6NNY8
RGLINLGNTCFMNCI

USP22

176

Q9UPT9
LGNTCFMNCIVQALT

USP22

181

Q9UPT9
TISMLLGNLNSCCNP

AVPR1B

321

P47901
NLGNTCFMNSALQCL

USP4

306

Q13107
CFMNSALQCLSNTAP

USP4

311

Q13107
TCQVCQMLLPNQCSF

ZNF592

741

Q92610
CSNMVQEFLLQCLCQ

HEATR9

291

A2RTY3
NTCFMNSAIQCLSNT

USP15

296

Q9Y4E8
QTDCYNNLAACLLQM

TTC9C

71

Q8N5M4
LRNLGNTCFMNAILQ

USP3

161

Q9Y6I4
NLGNTCFMNSILQCL

USP2

271

O75604
NLGNTCYMNSILQCL

USP8

781

P40818
NTCFMNSALQCLSNV

USP11

316

P51784
NLGNTCFMNSSIQCV

USP6

536

P35125
LLCILMFCNQQSVCD

ZMYM4

841

Q5VZL5
KSQMNCNLGTCQLQR

MUC12

5336

Q9UKN1
LAQSLGNMNQICVCI

NMD3

261

Q96D46