Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	USH2 complex	ADGRV1 USH2A	9.75e-05	4	85	2	GO:1990696
GeneOntologyCellularComponent	stereocilia ankle link	ADGRV1 USH2A	2.43e-04	6	85	2	GO:0002141
GeneOntologyCellularComponent	stereocilia ankle link complex	ADGRV1 USH2A	2.43e-04	6	85	2	GO:0002142
GeneOntologyCellularComponent	stereocilium membrane	ADGRV1 USH2A	2.43e-04	6	85	2	GO:0060171
GeneOntologyCellularComponent	periciliary membrane compartment	ADGRV1 USH2A	2.43e-04	6	85	2	GO:1990075
GeneOntologyCellularComponent	stereocilia coupling link	ADGRV1 USH2A	4.50e-04	8	85	2	GO:0002139
Domain	Cadherin-like	DCHS2 PCDHGB5 SGCA PCDH19 PCDHGB4 PCDH7	1.48e-05	116	85	6	IPR015919
Domain	CNH	MAP4K3 MAP4K5 TGFBRAP1	3.98e-05	15	85	3	PF00780
Domain	CNH	MAP4K3 MAP4K5 TGFBRAP1	3.98e-05	15	85	3	PS50219
Domain	CNH_dom	MAP4K3 MAP4K5 TGFBRAP1	3.98e-05	15	85	3	IPR001180
Domain	SPAR_C	SIPA1L3 SIPA1L2	6.12e-05	3	85	2	PF11881
Domain	SIPA1L_C	SIPA1L3 SIPA1L2	6.12e-05	3	85	2	IPR021818
Domain	MAPKKKK	MAP4K3 MAP4K5	1.22e-04	4	85	2	IPR021160
Domain	Cadherin_CS	DCHS2 PCDHGB5 PCDH19 PCDHGB4 PCDH7	1.40e-04	109	85	5	IPR020894
Domain	CADHERIN_1	DCHS2 PCDHGB5 PCDH19 PCDHGB4 PCDH7	1.66e-04	113	85	5	PS00232
Domain	Cadherin	DCHS2 PCDHGB5 PCDH19 PCDHGB4 PCDH7	1.66e-04	113	85	5	PF00028
Domain	CADHERIN_2	DCHS2 PCDHGB5 PCDH19 PCDHGB4 PCDH7	1.72e-04	114	85	5	PS50268
Domain	-	DCHS2 PCDHGB5 PCDH19 PCDHGB4 PCDH7	1.72e-04	114	85	5	2.60.40.60
Domain	CA	DCHS2 PCDHGB5 PCDH19 PCDHGB4 PCDH7	1.80e-04	115	85	5	SM00112
Domain	Cadherin	DCHS2 PCDHGB5 PCDH19 PCDHGB4 PCDH7	2.03e-04	118	85	5	IPR002126
Domain	CPSASE_1	CAD ACACB	2.03e-04	5	85	2	PS00866
Domain	Cadherin_2	PCDHGB5 PCDH19 PCDHGB4 PCDH7	2.19e-04	65	85	4	PF08266
Domain	Cadherin_N	PCDHGB5 PCDH19 PCDHGB4 PCDH7	2.19e-04	65	85	4	IPR013164
Domain	CPSASE_2	CAD ACACB	3.03e-04	6	85	2	PS00867
Domain	CPSase_L_D2	CAD ACACB	4.24e-04	7	85	2	PF02786
Domain	CbamoylP_synth_lsu-like_ATP-bd	CAD ACACB	4.24e-04	7	85	2	IPR005479
Domain	BC-like_N	CAD ACACB	4.24e-04	7	85	2	IPR005481
Domain	Biotin_carb_N	CAD ACACB	4.24e-04	7	85	2	PF00289
Domain	ARM-type_fold	SMG1 GPRASP1 PIK3CD RTTN NUP188 TARBP1 GPRASP2	8.96e-04	339	85	7	IPR016024
Domain	Rap_GAP	SIPA1L3 SIPA1L2	9.00e-04	10	85	2	PF02145
Domain	ARM-rpt_dom	GPRASP1 GPRASP2	1.10e-03	11	85	2	IPR006911
Domain	Rap_GAP_dom	SIPA1L3 SIPA1L2	1.10e-03	11	85	2	IPR000331
Domain	Arm_2	GPRASP1 GPRASP2	1.10e-03	11	85	2	PF04826
Domain	RAPGAP	SIPA1L3 SIPA1L2	1.10e-03	11	85	2	PS50085
Domain	-	CAD ACACB	1.55e-03	13	85	2	3.40.50.20
Domain	6-hairpin_glycosidase-like	AGL SPATA20	1.55e-03	13	85	2	IPR008928
Domain	ATP-grasp	CAD ACACB	1.80e-03	14	85	2	IPR011761
Domain	PreATP-grasp_dom	CAD ACACB	1.80e-03	14	85	2	IPR016185
Domain	CNH	MAP4K3 MAP4K5	1.80e-03	14	85	2	SM00036
Domain	ATP_GRASP	CAD ACACB	1.80e-03	14	85	2	PS50975
Domain	Sugar/inositol_transpt	SLC2A12 SLC2A4	1.80e-03	14	85	2	IPR003663
Domain	PI3/4_kinase_CS	SMG1 PIK3CD	2.07e-03	15	85	2	IPR018936
Domain	-	CAD ACACB	2.07e-03	15	85	2	3.30.1490.20
Domain	-	SMG1 PIK3CD	2.36e-03	16	85	2	1.10.1070.11
Domain	PI3Kc	SMG1 PIK3CD	2.36e-03	16	85	2	SM00146
Domain	SUGAR_TRANSPORT_2	SLC2A12 SLC2A4	2.66e-03	17	85	2	PS00217
Domain	PI3/4_kinase_cat_dom	SMG1 PIK3CD	2.99e-03	18	85	2	IPR000403
Domain	ATP_grasp_subdomain_1	CAD ACACB	2.99e-03	18	85	2	IPR013815
Domain	PI3_PI4_kinase	SMG1 PIK3CD	2.99e-03	18	85	2	PF00454
Domain	PI3_4_KINASE_3	SMG1 PIK3CD	2.99e-03	18	85	2	PS50290
Domain	PI3_4_KINASE_1	SMG1 PIK3CD	2.99e-03	18	85	2	PS00915
Domain	PI3_4_KINASE_2	SMG1 PIK3CD	2.99e-03	18	85	2	PS00916
Domain	-	CAD ACACB	2.99e-03	18	85	2	3.30.470.20
Domain	CH	GAS2L1 FLNC PLEC	3.24e-03	65	85	3	SM00033
Domain	CH	GAS2L1 FLNC PLEC	4.00e-03	70	85	3	PF00307
Domain	-	GAS2L1 FLNC PLEC	4.16e-03	71	85	3	1.10.418.10
Domain	CH	GAS2L1 FLNC PLEC	4.50e-03	73	85	3	PS50021
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	GAS2L1 FLNC CRYBG2 ARHGEF40 GAREM2 PLEKHM2 PIK3CD SIPA1L3 RTTN SPATA20 NUP188 PLEC SIPA1L2 KLHL17	6.15e-07	1105	87	14	35748872
Pubmed	Characteristics of Retinitis Pigmentosa Associated with ADGRV1 and Comparison with USH2A in Patients from a Multicentric Usher Syndrome Study Treatrush.	ADGRV1 USH2A	6.19e-06	2	87	2	34638692
Pubmed	GLUT12 functions as a basal and insulin-independent glucose transporter in the heart.	SLC2A12 SLC2A4	6.19e-06	2	87	2	23041416
Pubmed	FHL2 interacts with iASPP and impacts the biological functions of leukemia cells.	PPP1R13L FHL2	6.19e-06	2	87	2	28402264
Pubmed	The vesicle- and target-SNARE proteins that mediate Glut4 vesicle fusion are localized in detergent-insoluble lipid rafts present on distinct intracellular membranes.	SNAP23 SLC2A4	6.19e-06	2	87	2	12376543
Pubmed	Insulin-stimulated translocation of glucose transporter (GLUT) 12 parallels that of GLUT4 in normal muscle.	SLC2A12 SLC2A4	6.19e-06	2	87	2	19549745
Pubmed	Enhanced expressions of FHL2 and iASPP predict poor prognosis in acute myeloid leukemia.	PPP1R13L FHL2	6.19e-06	2	87	2	29910468
Pubmed	Usher's Syndrome Type II: A Comparative Study of Genetic Mutations and Vestibular System Evaluation.	ADGRV1 USH2A	6.19e-06	2	87	2	28653555
Pubmed	Disease expression in Usher syndrome caused by VLGR1 gene mutation (USH2C) and comparison with USH2A phenotype.	ADGRV1 USH2A	6.19e-06	2	87	2	15671307
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	LLGL1 ACACB MAP4K3 MAP4K5 PCDH19 SNAP23 SIPA1L2 PCDH7	1.09e-05	421	87	8	36976175
Pubmed	PRMT2 silencing regulates macrophage polarization through activation of STAT1 or inhibition of STAT6.	PRMT2 STAT6	1.85e-05	3	87	2	38172698
Pubmed	Respiratory failure, cleft palate and epilepsy in the mouse model of human Xq22.1 deletion syndrome.	GPRASP1 GPRASP2	1.85e-05	3	87	2	24569167
Pubmed	PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome.	ADGRV1 USH2A	1.85e-05	3	87	2	20440071
Pubmed	mgl-1, a mouse homologue of the Drosophila tumor-suppressor gene l(2)gl, maps to chromosome 11.	LLGL1 SLC2A4	1.85e-05	3	87	2	8020994
Pubmed	Novel interactions of ankyrins-G at the costameres: the muscle-specific Obscurin/Titin-Binding-related Domain (OTBD) binds plectin and filamin C.	FLNC PLEC	1.85e-05	3	87	2	21223964
Pubmed	Targeted next generation sequencing in Italian patients with Usher syndrome: phenotype-genotype correlations.	ADGRV1 USH2A	1.85e-05	3	87	2	29142287
Pubmed	Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle.	SLC2A12 SLC2A4	1.85e-05	3	87	2	16803853
Pubmed	RapGAPs in brain: multipurpose players in neuronal Rap signalling.	SIPA1L3 SIPA1L2	1.85e-05	3	87	2	20576033
Pubmed	The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1.	ADGRV1 USH2A	1.85e-05	3	87	2	16434480
Pubmed	Non-USH2A mutations in USH2 patients.	ADGRV1 USH2A	1.85e-05	3	87	2	22147658
Pubmed	Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).	ACACB SLC2A12 SLC2A4	2.25e-05	22	87	3	20965718
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FLNC ARHGEF40 CAD LLGL1 MAP4K3 LSG1 MAP4K5 MRPS23 SAMM50 PLEC FHL2 NONO AQR	3.11e-05	1353	87	13	29467282
Pubmed	Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina.	ADGRV1 USH2A	3.70e-05	4	87	2	37127773
Pubmed	Individual USH2 proteins make distinct contributions to the ankle link complex during development of the mouse cochlear stereociliary bundle.	ADGRV1 USH2A	3.70e-05	4	87	2	26401052
Pubmed	Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism.	ADGRV1 USH2A	3.70e-05	4	87	2	18463160
Pubmed	Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss.	ADGRV1 USH2A	3.70e-05	4	87	2	20502675
Pubmed	Deafness-Associated ADGRV1 Mutation Impairs USH2A Stability through Improper Phosphorylation of WHRN and WDSUB1 Recruitment.	ADGRV1 USH2A	3.70e-05	4	87	2	37066759
Pubmed	Regulated transport of the glucose transporter GLUT4.	SNAP23 SLC2A4	3.70e-05	4	87	2	11994746
Pubmed	Placental glucose transfer and fetal growth.	SLC2A12 SLC2A4	3.70e-05	4	87	2	12583599
Pubmed	Usher Syndrome Type II	ADGRV1 USH2A	3.70e-05	4	87	2	20301515
Pubmed	Alternative binding modes identified for growth and differentiation factor-associated serum protein (GASP) family antagonism of myostatin.	GPRASP1 GPRASP2	3.70e-05	4	87	2	25657005
Pubmed	Localization of PDZD7 to the stereocilia ankle-link associates this scaffolding protein with the Usher syndrome protein network.	ADGRV1 USH2A	3.70e-05	4	87	2	23055499
Pubmed	Whirlin and PDZ domain-containing 7 (PDZD7) proteins are both required to form the quaternary protein complex associated with Usher syndrome type 2.	ADGRV1 USH2A	3.70e-05	4	87	2	25406310
Pubmed	Extra-nuclear telomerase reverse transcriptase (TERT) regulates glucose transport in skeletal muscle cells.	SLC2A12 SLC2A4	3.70e-05	4	87	2	24970747
Pubmed	Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction.	FLNC FHL2	3.70e-05	4	87	2	17360532
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	CAD KRT75 PIK3CD MAP4K5 NONO TUBAL3	5.69e-05	266	87	6	19380743
Pubmed	A novel Usher protein network at the periciliary reloading point between molecular transport machineries in vertebrate photoreceptor cells.	ADGRV1 USH2A	6.16e-05	5	87	2	17906286
Pubmed	Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice.	ADGRV1 USH2A	6.16e-05	5	87	2	24334608
Pubmed	Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2.	ADGRV1 USH2A	6.16e-05	5	87	2	16301216
Pubmed	GPRASP proteins are critical negative regulators of hematopoietic stem cell transplantation.	GPRASP1 GPRASP2	6.16e-05	5	87	2	32027737
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	CAD TENT4B LSG1 SIPA1L3 ASCC1 MRPS23 SAMM50 PLEC PPP1R13L FHL2 NONO AQR	6.86e-05	1257	87	12	36526897
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	FLNC CAD LLGL1 LSG1 KCTD3 MRPS23 PLEC SIPA1L2 NONO COG4 AQR	8.12e-05	1082	87	11	38697112
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	UNC119B CAD LLGL1 LSG1 MAP4K5 ACAD9 ASCC1 MRPS23 SNAP23 SAMM50 SIPA1L2 PCDH7 AQR	8.13e-05	1487	87	13	33957083
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TTYH1 GPRASP1 DCHS2 FRY SIPA1L3 PRMT2 PLEC BTBD1 TARBP1 COG4 GPRASP2 STAT6	8.46e-05	1285	87	12	35914814
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CAD TENT4B LSG1 ACAD9 KAT8 SIPA1L3 KCTD3 ASCC1 MRPS23 SNAP23 FHL2 NONO AQR	8.70e-05	1497	87	13	31527615
Pubmed	Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression.	PIK3CD STAT6	9.22e-05	6	87	2	30930171
Pubmed	Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes.	SNAP23 SLC2A4	9.22e-05	6	87	2	10394363
Pubmed	PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential.	LLGL1 PCDHGB5 PCDH19 PCDH7	9.38e-05	94	87	4	32062451
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	LLGL1 KCTD3 CPE ADGRV1 SIPA1L2 SMC5 TUBAL3	1.05e-04	430	87	7	32581705
Pubmed	Biochemical characterization of native Usher protein complexes from a vesicular subfraction of tracheal epithelial cells.	ADGRV1 USH2A	1.29e-04	7	87	2	20058854
Pubmed	Whirlin replacement restores the formation of the USH2 protein complex in whirlin knockout photoreceptors.	ADGRV1 USH2A	1.29e-04	7	87	2	21212183
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	ARHGEF40 CAD KRT75 AGL AQR	1.58e-04	202	87	5	24639526
Pubmed	Genetic predisposition of responsiveness to therapy for chronic hepatitis C.	TGFBRAP1 CASP5	1.72e-04	8	87	2	16886895
Pubmed	Microarray-based mutation analysis of 183 Spanish families with Usher syndrome.	ADGRV1 USH2A	1.72e-04	8	87	2	19683999
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	GPRASP1 FLNC ACAD9 KCTD3 NUP188 PLEC BTBD1 TARBP1 GPRASP2 AQR	2.08e-04	1005	87	10	19615732
Pubmed	Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease.	CACNA1A CPE	2.20e-04	9	87	2	15917267
Pubmed	Molecular enzymology of carnitine transfer and transport.	SLC25A20 ACACB	2.20e-04	9	87	2	11257506
Pubmed	Identification of DeltaNp63alpha protein interactions by mass spectrometry.	FLNC CAD NONO	2.41e-04	48	87	3	20085233
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	SMG1 CAD ACAD9 EIF2B2 ASCC1 MRPS23 SNAP23 SAMM50 NUP188 NONO TAP1 COG4	2.44e-04	1440	87	12	30833792
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SPATC1 SMG1 FLNC KRT75 ACACB PCDHGB5 LSG1 SIPA1L3 PCDHGB4 PLEC SIPA1L2 NONO	2.47e-04	1442	87	12	35575683
Pubmed	DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.	UNC119B FLNC SIPA1L3 SIPA1L2	2.56e-04	122	87	4	30773093
Pubmed	Massively parallel DNA sequencing facilitates diagnosis of patients with Usher syndrome type 1.	ADGRV1 USH2A	2.75e-04	10	87	2	24618850
Pubmed	Usher protein functions in hair cells and photoreceptors.	ADGRV1 USH2A	2.75e-04	10	87	2	24239741
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	FLNC CAD PLEC FHL2 TUBAL3	3.18e-04	235	87	5	28378594
Pubmed	Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation.	SNAP23 SLC2A4	3.35e-04	11	87	2	12832401
Pubmed	Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.	FLNC USH2A	3.35e-04	11	87	2	24349473
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	ARHGEF40 CAD PPT2 ACAD9 MRPS23 NT5C2 SNAP23 NUP188 FHL2 TAP1 AQR	3.89e-04	1297	87	11	33545068
Pubmed	High-resolution mapping of mouse chromosome 8 identifies an evolutionary chromosomal breakpoint.	CACNA1A CPE	4.02e-04	12	87	2	9680377
Pubmed	Identification of epilepsy genes in human and mouse.	CACNA1A ADGRV1	4.02e-04	12	87	2	11700294
Pubmed	Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome.	FLNC SLC25A20 SAMM50 FHL2	5.19e-04	147	87	4	26465331
Pubmed	Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.	CACNA1A CRYBG2 ACAD9	5.39e-04	63	87	3	17672918
Pubmed	EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.	GAS2L1 PLEC PPP1R13L	5.39e-04	63	87	3	29162697
Pubmed	Identification of a novel family of G protein-coupled receptor associated sorting proteins.	GPRASP1 GPRASP2	5.52e-04	14	87	2	15086532
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	PCDH19 RTL9 HACE1 SIPA1L2	6.04e-04	153	87	4	10718198
Pubmed	14-3-3ε mediates the cell fate decision-making pathways in response of hepatocellular carcinoma to Bleomycin-induced DNA damage.	CAD NT5C2 NONO	6.17e-04	66	87	3	23472066
Pubmed	Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression.	PCDHGB5 PCDHGB4	6.36e-04	15	87	2	23515096
Pubmed	p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.	SMG1 LLGL1 SNAP23 SPATA20	6.97e-04	159	87	4	30581152
Pubmed	Linking nuclear matrix-localized PIAS1 to chromatin SUMOylation via direct binding of histones H3 and H2A.Z.	FLNC PLEC USH2A NONO	6.97e-04	159	87	4	34537242
Pubmed	Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.	ADGRV1 USH2A	7.26e-04	16	87	2	17567809
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHGB5 PCDHGB4 PCDH7	8.62e-04	74	87	3	10817752
Pubmed	AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.	SLC25A20 ACACB	9.22e-04	18	87	2	16054041
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHGB5 PCDHGB4 PCDH7	9.68e-04	77	87	3	10835267
Pubmed	Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.	FLNC FHL2	1.03e-03	19	87	2	27171814
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHGB5 PCDHGB4 PCDH7	1.08e-03	80	87	3	10716726
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	SMG1 FRY CAD MRPS23 SIPA1L2 PPP1R13L SLC2A12	1.12e-03	639	87	7	23443559
Pubmed	Limb-Girdle Muscular Dystrophy Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	SGCA PLEC	1.26e-03	21	87	2	20301582
Pubmed	A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.	KCTD3 BTBD1 KLHL17	1.38e-03	87	87	3	37495603
Pubmed	Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic-Like Behaviors.	STAT6 CFAP65	1.38e-03	22	87	2	33304758
Pubmed	Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.	CAD AGL ADGRV1 BTBD1 NONO TUBAL3	1.54e-03	495	87	6	28581483
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	MAP4K3 PIK3CD ACAD9 SNAP23 DHDDS NUP188 PLEC COG4 STAT6	1.57e-03	1084	87	9	11544199
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	SMG1 FLNC SGCA AGL PLEC BTBD1	1.57e-03	497	87	6	23414517
Pubmed	Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events.	GPRASP1 GPRASP2	1.65e-03	24	87	2	16221301
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	ACACB SAMM50 PLEC FHL2 NONO STAT6	1.67e-03	503	87	6	36217030
Pubmed	RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.	CAD PLEKHM2 MRPS23 NUP188 TUBAL3	1.75e-03	344	87	5	36282215
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	LSG1 SIPA1L3 SIPA1L2 PPP1R13L	1.91e-03	209	87	4	36779422
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	SMG1 UNC119B ARHGEF40 MAP4K3 MAP4K5 NUP188 PLEC TUBAL3	2.02e-03	910	87	8	36736316
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	FLNC HACE1 PLEC PCDH7	2.08e-03	214	87	4	22199357
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	FLNC MAP4K5 PLEC SMC5 NONO	2.13e-03	360	87	5	33111431
Pubmed	MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation.	MAP4K3 MAP4K5 ACAD9 MRPS23	2.15e-03	216	87	4	32640226
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	SMG1 LLGL1 MAP4K3 SIPA1L3 RTTN SNAP23 TARBP1	2.19e-03	719	87	7	35337019
Interaction	KRT8 interactions	SMG1 CAD KRT75 MAP4K3 LSG1 SIPA1L3 NUP188 PLEC SIPA1L2 PCDH7 COG4	3.06e-06	441	87	11	int:KRT8
Cytoband	Xq22.1	GPRASP1 PCDH19 GPRASP2	7.68e-05	43	87	3	Xq22.1
GeneFamily	Fibronectin type III domain containing\|USH2 complex	ADGRV1 USH2A	6.04e-05	4	58	2	1244
GeneFamily	Mitogen-activated protein kinase kinase kinase kinases	MAP4K3 MAP4K5	1.01e-04	5	58	2	655
GeneFamily	Non-clustered protocadherins	PCDH19 PCDH7	6.54e-04	12	58	2	21
Coexpression	GSE22886_IGG_IGA_MEMORY_BCELL_VS_BM_PLASMA_CELL_UP	GPRASP1 FRY PIK3CD AGL SNAP23 TARBP1 STAT6	4.38e-06	200	86	7	M4449
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGEF40 GAREM2 PCDH19 PAGR1 FHL2 PCDH7	1.12e-06	172	87	6	de4961f4037c439d3e0ec706a257b0ec17f4d5be
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TTYH1 DCHS2 ATP13A4 CPE ADGRV1 SLC2A12	2.68e-06	200	87	6	d0812817ef99608994193787a62d39adeb2070ca
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TTYH1 DCHS2 ATP13A4 CPE ADGRV1 SLC2A12	2.68e-06	200	87	6	cd54ddf1919c98e84b7e4aba85b374fc8b407206
ToppCell	Basal_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	KRT75 PPP1R13L FHL2 PCDH7 SOAT2	1.76e-05	164	87	5	85487a303194f5244956ec1ca2d1758d38117f41
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRYBG2 PIK3CD SMC5 ITGB7 KLHL17	2.27e-05	173	87	5	de124fb7ded04664d4184bf12f1f201c0784f07c
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	FLNC FRY ACACB FHL2 PCDH7	3.05e-05	184	87	5	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	droplet-Lung-nan-3m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTYH1 ACAD9 TGFBRAP1 CPE PCDH7	3.13e-05	185	87	5	6a85399cfdb9b89683c874e7f046957f9a601dc2
ToppCell	droplet-Lung-nan-3m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTYH1 ACAD9 TGFBRAP1 CPE PCDH7	3.13e-05	185	87	5	64791056cdbb739136dbef08f4b16e2b5427faad
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SPATC1 ATP13A4 ACACB GAREM2 ADGRV1	3.21e-05	186	87	5	73cf266aeecd3cc15e8cb6094588a393bca8fbe6
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNC SGCA CPE PCDH7 SLC2A4	3.30e-05	187	87	5	218c9b4f28499389c43005d9626af2ac01066027
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SPATC1 ATP13A4 ACACB GAREM2 ADGRV1	3.30e-05	187	87	5	401be371b32066db926de3415bb4ce9465749dc3
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNC SGCA CPE PCDH7 SLC2A4	3.30e-05	187	87	5	c7ac4b328efc2ebb72f71154661914193ff402ca
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Airway_Smooth_Muscle\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC SGCA CPE PCDH7 SLC2A4	3.38e-05	188	87	5	61f010c165826b434ca3d27553d4c9e13d2c0c51
ToppCell	droplet-Lung-nan-18m-Mesenchymal-bronchial_smooth_muscle_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC SGCA CPE PCDH7 SLC2A4	3.38e-05	188	87	5	7553ef7de3575af4cf34704b405b551c1af8eb83
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SPATC1 ATP13A4 ACACB GAREM2 ADGRV1	3.56e-05	190	87	5	78cc6c28b31de041c24175a98f47da256ecc15a2
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SPATC1 ATP13A4 ACACB GAREM2 ADGRV1	3.56e-05	190	87	5	5c64b727669b23d2a23c8ad1d5d6caab7af37d56
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SPATC1 ATP13A4 ACACB GAREM2 ADGRV1	3.56e-05	190	87	5	e67d9400467b438592690b23d681e6c2fb8f09fd
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SPATC1 ATP13A4 ACACB GAREM2 ADGRV1	3.56e-05	190	87	5	b56c55f608b30f7379941ac7d5f0f5200f305fca
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TTYH1 FRY FIBIN CPE FHL2	3.65e-05	191	87	5	f9a46956778a8773d6656340ecf5d218376d79c2
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SPATC1 ATP13A4 ACACB GAREM2 ADGRV1	3.74e-05	192	87	5	f7e4509003d71f805b9d4587098e90d2897b6739
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SPATC1 ATP13A4 ACACB GAREM2 ADGRV1	3.74e-05	192	87	5	43beaac1de99b9c1a6dab4a450b4e81286987b64
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SPATC1 ATP13A4 ACACB GAREM2 ADGRV1	3.74e-05	192	87	5	705ce805cb00a53793b57bcf466d0fbec590a83c
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SPATC1 ATP13A4 ACACB GAREM2 ADGRV1	3.83e-05	193	87	5	b03d908d4b8940927f72c76a1b0f237d13f39056
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SPATC1 ATP13A4 ACACB GAREM2 ADGRV1	3.83e-05	193	87	5	40edc07b6e7f19f6ee885fa5af0b63ef1b0f2468
ToppCell	Macroglial-Astrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	SPATC1 ATP13A4 ACACB CPE ADGRV1	4.54e-05	200	87	5	941536b7c32f1e63c70535233b2ccce0cd7bf96e
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FLNC FRY CPE PCDH7 SLC2A4	4.54e-05	200	87	5	a66449b22b39dd6987fc2c3ed160d24564234ced
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TTYH1 ATP13A4 CPE ADGRV1 SLC2A12	4.54e-05	200	87	5	7a8160e6477708f22e48c609bf8f43f3715dcb03
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DCHS2 ATP13A4 CPE ADGRV1 SLC2A12	4.54e-05	200	87	5	07d942803360e1a1e8e131d6e31c726dd0db1a0b
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Serous\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TTYH1 LLGL1 DHDDS GPRASP2 AQR	4.54e-05	200	87	5	61bae10c8b12196d9cee766897971b81cb897191
Disease	liver fat measurement	MAP4K5 TGFBRAP1 SAMM50 PLEC	6.93e-06	43	84	4	EFO_0010821
Disease	valine measurement	ACACB MAP4K5 SLC2A4	2.04e-04	40	84	3	EFO_0009792
Disease	serum albumin measurement	FRY LLGL1 MAP4K3 MAP4K5 RTL9 ADGRV1 PLEC PCDH7	2.86e-04	592	84	8	EFO_0004535
Disease	response to tenofovir, creatinine clearance measurement	NT5C2 OR5M3 OR5M8 PCDH7	3.00e-04	112	84	4	EFO_0007934, EFO_0009279
Disease	Insulin Resistance	ACACB CPE SLC2A4	6.77e-04	60	84	3	C0021655
Disease	Insulin Sensitivity	ACACB CPE SLC2A4	6.77e-04	60	84	3	C0920563
Disease	neuronal ceroid lipofuscinosis (implicated_via_orthology)	ATP13A4 PPT2	7.13e-04	14	84	2	DOID:14503 (implicated_via_orthology)
Disease	Autosomal recessive limb-girdle muscular dystrophy	SGCA PLEC	7.13e-04	14	84	2	cv:C2931907
Disease	lysophosphatidylcholine 14:0 measurement	CAD MAP4K5	8.21e-04	15	84	2	EFO_0010356
Disease	Congenital total cataract	CRYAA SIPA1L3	9.36e-04	16	84	2	C0266539
Disease	bipolar disorder, sex interaction measurement	SIPA1L2 FHL2	1.19e-03	18	84	2	EFO_0008343, MONDO_0004985
Disease	mental development measurement	PCDHGB5 PCDHGB4	2.30e-03	25	84	2	EFO_0008230
Disease	fasting blood glucose measurement, HOMA-B, fasting blood insulin measurement	MAP4K5 OR1L3	2.30e-03	25	84	2	EFO_0004465, EFO_0004466, EFO_0004469
Disease	Limb-girdle muscular dystrophy	SGCA PLEC	2.49e-03	26	84	2	cv:C0686353
Disease	glucose tolerance test	MAP4K5 SLC2A4	2.68e-03	27	84	2	EFO_0004307

Protein segments in the cluster

Peptide	Gene	Start	Entry
RLGEAVRTELTTLEE	TTYH1	146	Q9H313
ILATVGTEFDLRTLR	CACNA1A	181	O00555
GTEFDLRTLRAVRVL	CACNA1A	186	O00555
ISDLETLRGELRFDI	PRMT2	316	P55345
GDTLSALQETELRFR	ARHGEF40	811	Q8TER5
LIRGLEVTSTEVVDR	ARHGEF40	1036	Q8TER5
ESLGFELTVERLVSI	NT5C2	66	P49902
RVVTLVTFAGTLLER	BCL2L10	96	Q9HD36
RETVESDLIFLGLLI	ATP13A4	676	Q4VNC1
TLTLLFEGIARIVET	COG4	271	Q9H9E3
LRDTRILLIFEGTNE	ACAD9	416	Q9H845
TSTTVIRLIIERIGE	ADGRV1	46	Q8WXG9
EQTLTLIFLDGERER	ADGRV1	5296	Q8WXG9
VISARTRIDVLLDTF	ASCC1	141	Q8N9N2
TQLEEFRASELLRSG	AQR	1006	O60306
EQILRTGRDLFSLDS	PAGR1	216	Q9BTK6
VLGRLRALSDTTEEL	SLC2A12	236	Q8TD20
SGELLVSSRLDREEI	PCDHGB4	81	Q9UN71
LRAETLVTLDFTSRI	LLGL1	326	Q15334
LKELSIRGDFRTTVE	ACACB	721	O00763
SFSTILVDGRLDREQ	PCDH19	401	Q8TAB3
ETESILGRIIRVTDE	TENT4B	406	Q8NDF8
IESETTFSLIFRLRE	MUC16	6356	Q8WXI7
EISDSTRIFRLLGSD	MAP4K3	851	Q8IVH8
TRIFRLLGSDRVVVL	MAP4K3	856	Q8IVH8
FGFIRLETRTLAEIA	NONO	111	Q15233
FTEILNGASRRLELV	MAGEB1	146	P43366
EARTGLLSFEESQRI	LSG1	86	Q9H089
FTLVSVLLVERAGRR	SLC2A4	336	P14672
EILRDFRGTLSIKDL	KAT8	371	Q9H7Z6
ILVEASRGEVVLTSR	CFAP65	1871	Q6ZU64
VRFETGLIELELSNR	KIAA1109	3176	Q2LD37
TESVRRLLRLDETSG	PCDH7	351	O60245
LREVTTEFTVDARSL	FLNC	1266	Q14315
EERVLLLQFVTGSSR	HACE1	826	Q8IYU2
DVLRELIRDEGVTSL	SLC25A20	251	O43772
SGELLVSSRLDREEI	PCDHGB5	81	Q9Y5G0
DVTEFILLGLTSRRE	OR5M3	6	Q8NGP4
RLRALGFSEELIVEL	ITGB7	456	P26010
FGTLVTVSRLDRESI	DCHS2	1566	Q6V1P9
TVVTVLDLFDGRESL	PPT2	66	Q9UMR5
RTLVSGLLLEDSVRV	FOXO3B	171	A0A2Z4LIS9
FTRRSSVGVAVLELL	KLHL17	611	Q6TDP4
RDRTRGSIFITELIT	CASP5	371	P51878
RVGDSSLLIFVRVLR	GAS2L1	236	Q99501
DTLSIRESRLFGAVV	BTBD1	231	Q9H0C5
DELLTSLRVIRTDFG	CRYBG2	1246	Q8N1P7
RSFEGRELLVIELSD	CPE	81	P16870
LSLVGRGFLTERDDI	FHL2	256	Q14192
RLESIEITESLVLGF	FRY	976	Q5TBA9
GRTNSLVFRELVEEL	FRY	991	Q5TBA9
SLFRTVLDSGISEVR	CRYAA	51	P02489
LSERIESFVETLKRG	EIF2B2	11	P49770
LSLTLREEFTVLGRQ	FIBIN	76	Q8TAL6
DILIRTSGEVRLSDF	DHDDS	201	Q86SQ9
LDVTFEVTELRRLTG	SAMM50	116	Q9Y512
ELSFREGESVTVLRR	PPP1R13L	776	Q8WUF5
RISTLRDETGAIFID	KCTD3	51	Q9Y597
TQEISDETRVFRLLG	MAP4K5	801	Q9Y4K4
FRLLGSDRVVVLESR	MAP4K5	811	Q9Y4K4
TLVSGLEFIRFELDL	PLEKHM2	141	Q8IWE5
EFILLGLSSRSEDQR	OR1L3	11	Q8NH93
FIRDSGVVSLIETLL	GPRASP1	1191	Q5JY77
LEEVSRSLRFIGLSE	GAREM2	811	Q75VX8
RSLRFIGLSEDVVSF	GAREM2	816	Q75VX8
LETVGSIFSRTRDLV	MRPS23	6	Q9Y3D9
SDAILRTRFLEGLSE	RTL9	1266	Q8NET4
IDARVLSRVTDLFIG	RTTN	796	Q86VV8
TNREILEVFSGDLLR	USH2A	281	O75445
RDFIRDSGVVSLIET	GPRASP2	631	Q96D09
LLRVFSTVVRSIGER	SMG1	401	Q96Q15
ITDESLESTRRILGL	SNAP23	16	O00161
RTSELTTLRGAILED	SIPA1L2	536	Q9P2F8
GDFSEVRRVLKLLET	SELENOO	611	Q9BVL4
FRTRELITLRGSILE	SIPA1L3	551	O60292
GSETRRLSLFLVLVV	TAP1	181	Q03518
TLVTEFILLGLTSRR	OR5M8	6	Q8NGP6
SVGSEVIDLVLERTR	TUBAL3	116	A6NHL2
DSFDTTRQRLVLEIG	SGCA	111	Q16586
QSGERLSAFVLRLEV	PNMA6A	251	P0CW24
ISTLAIDFIDEGRLL	SOAT2	136	O75908
ELFRSGQLDVRELIS	TGFBRAP1	371	Q8WUH2
SLETRVVLNGREETL	nan	481	Q6ZTK2
VGEIAFQLDRRILSS	SPATC1	446	Q76KD6
SEIIGKRELRSESIF	TMEM232	226	C9JQI7
SLTGRLDEVLRTLVT	STAT6	256	P42226
EDGLTRVGFRTVLLR	SPATA20	186	Q8TB22
FTRFKIRDLETGTVL	UNC119B	96	A6NIH7
SVVRRQLFLDVLDGT	NUP188	1126	Q5SRE5
RTGLIEVVLRSDTIA	PIK3CD	821	O00329
EVETLRQERLSFSGL	PLEC	3431	Q15149
ALLDIFTIREELGTV	CAD	2056	P27708
GEASAERVETLRFLL	TARBP1	26	Q13395
ELFRASGNLVITREI	SMC5	126	Q8IY18
VFVTRLGISSLIREA	AGL	566	P35573
LESITTERGRLEAEL	KRT75	211	O95678