Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	fatty acid elongase activity	ELOVL1 ELOVL2	4.87e-05	7	31	2	GO:0009922
GeneOntologyMolecularFunction	acyltransferase activity, transferring groups other than amino-acyl groups	ELOVL1 MOGAT1 NAA11 ELOVL2	4.81e-04	238	31	4	GO:0016747
GeneOntologyMolecularFunction	transforming growth factor beta receptor binding	SMURF1 SMURF2	1.05e-03	31	31	2	GO:0005160
GeneOntologyMolecularFunction	acyltransferase activity	ELOVL1 SMURF1 MOGAT1 NAA11 SMURF2 ELOVL2	1.07e-03	775	31	6	GO:0016746
GeneOntologyBiologicalProcess	fatty acid elongation, polyunsaturated fatty acid	ELOVL1 ELOVL2	4.57e-05	7	31	2	GO:0034626
GeneOntologyBiologicalProcess	fatty acid elongation, monounsaturated fatty acid	ELOVL1 ELOVL2	4.57e-05	7	31	2	GO:0034625
GeneOntologyBiologicalProcess	fatty acid elongation, unsaturated fatty acid	ELOVL1 ELOVL2	4.57e-05	7	31	2	GO:0019368
GeneOntologyBiologicalProcess	fatty acid elongation, saturated fatty acid	ELOVL1 ELOVL2	6.09e-05	8	31	2	GO:0019367
GeneOntologyBiologicalProcess	alpha-linolenic acid metabolic process	ELOVL1 ELOVL2	9.76e-05	10	31	2	GO:0036109
GeneOntologyBiologicalProcess	sulfur compound biosynthetic process	ELOVL1 AKR1A1 HS3ST2 ELOVL2	1.41e-04	178	31	4	GO:0044272
GeneOntologyBiologicalProcess	very long-chain fatty acid biosynthetic process	ELOVL1 ELOVL2	1.69e-04	13	31	2	GO:0042761
GeneOntologyBiologicalProcess	fatty acid elongation	ELOVL1 ELOVL2	2.27e-04	15	31	2	GO:0030497
GeneOntologyBiologicalProcess	long-chain fatty-acyl-CoA biosynthetic process	ELOVL1 ELOVL2	3.68e-04	19	31	2	GO:0035338
GeneOntologyCellularComponent	radial spoke stalk	CFAP91 CFAP61	6.38e-06	3	31	2	GO:0001536
GeneOntologyCellularComponent	radial spoke	CFAP91 CFAP61	2.21e-04	15	31	2	GO:0001534
Domain	ELO_CS	ELOVL1 ELOVL2	3.98e-05	6	31	2	IPR030457
Domain	ELO	ELOVL1 ELOVL2	5.57e-05	7	31	2	PF01151
Domain	ELO	ELOVL1 ELOVL2	5.57e-05	7	31	2	PS01188
Domain	ELO_fam	ELOVL1 ELOVL2	5.57e-05	7	31	2	IPR002076
Domain	HECT	SMURF1 SMURF2	9.12e-04	27	31	2	PF00632
Domain	HECTc	SMURF1 SMURF2	9.12e-04	27	31	2	SM00119
Domain	HECT_dom	SMURF1 SMURF2	9.12e-04	27	31	2	IPR000569
Domain	HECT	SMURF1 SMURF2	9.12e-04	27	31	2	PS50237
Domain	-	CFAP61 NAA11	2.00e-03	40	31	2	3.40.630.30
Domain	Acyl_CoA_acyltransferase	CFAP61 NAA11	2.52e-03	45	31	2	IPR016181
Domain	WW	SMURF1 SMURF2	2.75e-03	47	31	2	PF00397
Domain	WW	SMURF1 SMURF2	2.87e-03	48	31	2	SM00456
Domain	WW_DOMAIN_2	SMURF1 SMURF2	3.23e-03	51	31	2	PS50020
Domain	WW_DOMAIN_1	SMURF1 SMURF2	3.23e-03	51	31	2	PS01159
Domain	WW_dom	SMURF1 SMURF2	3.36e-03	52	31	2	IPR001202
Domain	C2	SMURF1 SMURF2	1.99e-02	131	31	2	PF00168
Pathway	REACTOME_LINOLEIC_ACID_LA_METABOLISM	ELOVL1 ELOVL2	8.40e-05	8	25	2	MM14822
Pathway	REACTOME_LINOLEIC_ACID_LA_METABOLISM	ELOVL1 ELOVL2	8.40e-05	8	25	2	M27115
Pathway	WP_ELONGATION_OF_VERY_LONG_CHAIN_FATTY_ACIDS	ELOVL1 ELOVL2	1.97e-04	12	25	2	MM17077
Pathway	REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM	ELOVL1 ELOVL2	2.33e-04	13	25	2	MM14821
Pathway	REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM	ELOVL1 ELOVL2	2.33e-04	13	25	2	M27114
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	ELOVL1 ELOVL2	2.71e-04	14	25	2	MM15840
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	ELOVL1 ELOVL2	2.71e-04	14	25	2	M39780
Pathway	BIOCARTA_EFP_PATHWAY	SMURF1 SMURF2	3.57e-04	16	25	2	M22011
Pathway	REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS	ELOVL1 ELOVL2	6.82e-04	22	25	2	MM15451
Pathway	REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS	ELOVL1 ELOVL2	8.14e-04	24	25	2	M1016
Pathway	REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING	SMURF1 SMURF2	9.56e-04	26	25	2	M628
Pathway	REACTOME_SIGNALING_BY_BMP	SMURF1 SMURF2	1.36e-03	31	25	2	M1662
Pathway	REACTOME_SIGNALING_BY_BMP	SMURF1 SMURF2	1.36e-03	31	25	2	MM14789
Pathway	REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS	ELOVL1 ELOVL2	1.45e-03	32	25	2	MM15446
Pathway	REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS	ELOVL1 ELOVL2	1.94e-03	37	25	2	M729
Pathway	PID_BMP_PATHWAY	SMURF1 SMURF2	2.49e-03	42	25	2	M181
Pathway	WP_HEDGEHOG_SIGNALING_WP4249	SMURF1 SMURF2	2.61e-03	43	25	2	M39706
Pubmed	Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids.	ELOVL1 ELOVL2	7.69e-07	2	31	2	10791983
Pubmed	The functions and regulation of Smurfs in cancers.	SMURF1 SMURF2	7.69e-07	2	31	2	31899247
Pubmed	Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells.	SMURF1 SMURF2	7.69e-07	2	31	2	18927080
Pubmed	SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis.	SMURF1 SMURF2	7.69e-07	2	31	2	33090007
Pubmed	Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma.	SMURF1 SMURF2	2.31e-06	3	31	2	37537194
Pubmed	A conserved CaM- and radial spoke associated complex mediates regulation of flagellar dynein activity.	CFAP91 CFAP61	2.31e-06	3	31	2	17967944
Pubmed	The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1.	SMURF1 SMURF2	2.31e-06	3	31	2	23475958
Pubmed	Bortezomib prevents oncogenesis and bone metastasis of prostate cancer by inhibiting WWP1, Smurf1 and Smurf2.	SMURF1 SMURF2	2.31e-06	3	31	2	25051198
Pubmed	USF2 inhibits the transcriptional activity of Smurf1 and Smurf2 to promote breast cancer tumorigenesis.	SMURF1 SMURF2	2.31e-06	3	31	2	30244169
Pubmed	Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice.	SMURF1 SMURF2	2.31e-06	3	31	2	15173588
Pubmed	Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.	SMURF1 SMURF2	2.31e-06	3	31	2	24925320
Pubmed	Non-proteolytic ubiquitin modification of PPARγ by Smurf1 protects the liver from steatosis.	SMURF1 SMURF2	4.61e-06	4	31	2	30566427
Pubmed	Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein.	SMURF1 SMURF2	4.61e-06	4	31	2	34370213
Pubmed	Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.	SMURF1 SMURF2	4.61e-06	4	31	2	16373342
Pubmed	Nedd8 targets ubiquitin ligase Smurf2 for neddylation and promote its degradation.	SMURF1 SMURF2	4.61e-06	4	31	2	27086113
Pubmed	Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids.	ELOVL1 ELOVL2	4.61e-06	4	31	2	10970790
Pubmed	The WW1 Domain Enhances Autoinhibition in Smurf Ubiquitin Ligases.	SMURF1 SMURF2	4.61e-06	4	31	2	31628949
Pubmed	Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity.	SMURF1 SMURF2	7.68e-06	5	31	2	20937913
Pubmed	An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network.	SMURF1 SMURF2	7.68e-06	5	31	2	28839186
Pubmed	Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts.	SMURF1 SMURF2	7.68e-06	5	31	2	14722617
Pubmed	Inhibition of HECT E3 ligases as potential therapy for COVID-19.	SMURF1 SMURF2	7.68e-06	5	31	2	33762578
Pubmed	Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection.	SMURF1 SMURF2	7.68e-06	5	31	2	21402695
Pubmed	NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.	SMURF1 SMURF2	7.68e-06	5	31	2	28798345
Pubmed	Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling.	SMURF1 SMURF2	1.15e-05	6	31	2	21897371
Pubmed	ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2-MRCKα balance.	SMURF1 SMURF2	1.15e-05	6	31	2	28049720
Pubmed	Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.	SMURF1 SMURF2	1.15e-05	6	31	2	32361710
Pubmed	Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells.	SMURF1 SMURF2	1.15e-05	6	31	2	19318350
Pubmed	Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways.	SMURF1 SMURF2	1.15e-05	6	31	2	22921829
Pubmed	Hepatitis C virus/human interactome identifies SMURF2 and the viral protease as critical elements for the control of TGF-β signaling.	SMURF1 SMURF2	1.15e-05	6	31	2	23781096
Pubmed	CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription.	SMURF1 SMURF2	1.61e-05	7	31	2	14701756
Pubmed	A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases.	SMURF1 SMURF2	1.61e-05	7	31	2	30587574
Pubmed	SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis.	SMURF1 SMURF2	1.61e-05	7	31	2	27292644
Pubmed	The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function.	SMURF1 SMURF2	1.61e-05	7	31	2	28169289
Pubmed	A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.	SMURF1 SMURF2	2.15e-05	8	31	2	19307600
Pubmed	Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1.	SMURF1 SMURF2	2.15e-05	8	31	2	28881580
Pubmed	Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.	SMURF1 SMURF2	2.15e-05	8	31	2	20484049
Pubmed	Formin 2 Regulates Lysosomal Degradation of Wnt-Associated β-Catenin in Neural Progenitors.	SMURF1 SMURF2	2.76e-05	9	31	2	29659741
Pubmed	ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.	ELOVL1 ELOVL2	3.44e-05	10	31	2	20937905
Pubmed	Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).	SMURF1 SMURF2	3.44e-05	10	31	2	15221015
Pubmed	Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.	SMURF1 SMURF2	3.44e-05	10	31	2	15138260
Pubmed	Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.	SMURF1 SMURF2	3.44e-05	10	31	2	25092867
Pubmed	CFAP61 is required for sperm flagellum formation and male fertility in human and mouse.	CFAP91 CFAP61	3.44e-05	10	31	2	34792097
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	LARS1 ELOVL1 AKR1A1 FGG NT5C3A RYR1	4.00e-05	732	31	6	34732716
Pubmed	Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.	ELOVL1 ELOVL2	4.21e-05	11	31	2	23689133
Pubmed	Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.	SMURF1 SMURF2	4.21e-05	11	31	2	17996703
Pubmed	USP11 augments TGFβ signalling by deubiquitylating ALK5.	SMURF1 SMURF2	4.21e-05	11	31	2	22773947
Pubmed	NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation.	SMURF1 SMURF2	5.05e-05	12	31	2	24107629
Pubmed	TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.	SMURF1 SMURF2	6.95e-05	14	31	2	21791611
Pubmed	HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.	SMURF1 SMURF2	6.95e-05	14	31	2	26147758
Pubmed	Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer.	SMURF1 SMURF2	6.95e-05	14	31	2	29263404
Pubmed	Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.	SMURF1 SMURF2	9.16e-05	16	31	2	25723849
Pubmed	RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.	SMURF1 SMURF2	1.04e-04	17	31	2	28292929
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	ELOVL1 NMUR1 DENND1B CLCN4 SMURF2 RYR1 TAX1BP1	1.16e-04	1293	31	7	15342556
Pubmed	SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.	SMURF1 SMURF2	1.30e-04	19	31	2	21572392
Pubmed	Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.	SMURF1 SMURF2	1.60e-04	21	31	2	37005481
Pubmed	Bone morphogenetic proteins.	SMURF1 SMURF2	1.92e-04	23	31	2	15621726
Pubmed	Regulation of planar cell polarity by Smurf ubiquitin ligases.	SMURF1 SMURF2	2.28e-04	25	31	2	19379695
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	SMURF1 SMURF2	2.47e-04	26	31	2	26949039
Pubmed	Bmp2 and Notch cooperate to pattern the embryonic endocardium.	SMURF1 SMURF2	2.47e-04	26	31	2	29853617
Pubmed	Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.	ELOVL1 ELOVL2	2.66e-04	27	31	2	25269881
Pubmed	Biosynthesis of triacylglycerols.	ELOVL1 ELOVL2	2.86e-04	28	31	2	8944226
Pubmed	TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis.	SMURF1 SMURF2	3.29e-04	30	31	2	23973329
Interaction	LDLRAD4 interactions	SMURF1 MAGT1 SMURF2 TAX1BP1	1.96e-06	59	31	4	int:LDLRAD4
CoexpressionAtlas	DevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_1000	GREB1L GXYLT2 NXPE2 MAGT1 DENND1B NAA11 SMURF2 RYR1	1.05e-05	795	30	8	gudmap_developingGonad_e16.5_ovary_1000
CoexpressionAtlas	DevelopingGonad_e16.5_ovary_emap-9563_k-means-cluster#5_top-relative-expression-ranked_1000	GREB1L GXYLT2 NXPE2 DENND1B RYR1	1.29e-05	219	30	5	gudmap_developingGonad_e16.5_ovary_1000_k5
Disease	prostate cancer (implicated_via_orthology)	P4HA3 MAGT1	5.17e-04	33	30	2	DOID:10283 (implicated_via_orthology)
Disease	chin morphology measurement	DENND1B MOGAT1	2.31e-03	70	30	2	EFO_0007842

Protein segments in the cluster

Peptide	Gene	Start	Entry
YPYMVEWYTKSHGLL	NT5C3A	146	Q9H0P0
LHYNRYHLPMYAWPG	CFAP61	1221	Q8NHU2
LLYHSMHYYLNNIWP	ADGRD1	426	Q6QNK2
YFLRRGKYPDYQHWM	CRYGA	56	P11844
LVLFYVEYHTPWYMA	CLCN4	316	P51793
MFSNLIHYPRYSLYW	CFAP91	76	Q7Z4T9
MYPTYWYHDPRTFQL	MMP26	226	Q9NRE1
WHVYNPVLQLPYYEM	RBM11	146	P57052
ADTPYHLYPAYGWVM	PLLP	56	Q9Y342
AYDMGDYYHAIPWLE	P4HA3	191	Q7Z4N8
YIPYLMWLYFDWHTP	MOGAT1	51	Q96PD6
GMYVLHLESWLQYFP	HS3ST2	251	Q9Y278
WMLSIFRSKYHGYPY	MAGT1	316	Q9H0U3
LVGLPLELYEMWHNY	NMUR1	111	Q9HB89
LELYEMWHNYPFLLG	NMUR1	116	Q9HB89
GLAWEDMLYPLYQKY	GXYLT2	291	A0PJZ3
EYEMPLYRKYWPNHI	GREB1L	1551	Q9C091
IIGDFWLHSPMYYFL	OR5T1	61	Q8NG75
WLHSPMYYFLGVLSF	OR5T1	66	Q8NG75
MSWSLHPRNLILYFY	FGG	1	P02679
HILEMYEGWYRGYTL	DOCK5	36	Q9H7D0
YYGLSVFPSMHKYLW	ELOVL2	186	Q9NXB9
NYQYPVIIHLIWMYG	ELOVL1	226	Q9BW60
GSAALLYPMYWQHIY	DENND1B	231	Q6P3S1
LYLGWYMVMSLLGHY	RYR1	4791	P21817
RDYYTFLWSPMPEHY	TAX1BP1	61	Q86VP1
IYLMGDSTLHQWIYY	NXPE2	361	Q96DL1
HLSYYLYNHVAMWPE	LARS1	681	Q9P2J5
EWLYLLCHEMLNPYY	SMURF1	446	Q9HCE7
YLDLYLMHWPYAFER	AKR1A1	106	P14550
WLYLLSHEMLNPYYG	SMURF2	441	Q9HAU4
YQMKYYLYHGLSWPQ	NAA11	26	Q9BSU3
IWYKGQLMDLYHYIT	PSG5	66	Q15238