Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionfructose-bisphosphate aldolase activity

ALDOA ALDOB ALDOC

4.59e-0731553GO:0004332
GeneOntologyMolecularFunctionaldehyde-lyase activity

ALDOA ALDOB ALDOC

7.23e-05111553GO:0016832
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

INSR IGF1R EFEMP1 LTK EPHA10

1.50e-04651555GO:0004714
GeneOntologyMolecularFunctioninsulin receptor activity

INSR IGF1R

1.79e-0431552GO:0005009
GeneOntologyCellularComponentprotein complex involved in cell adhesion

ITGA2 ITGA5 ITGAE ITGB5 NID1

7.62e-05591555GO:0098636
GeneOntologyCellularComponentintegrin complex

ITGA2 ITGA5 ITGAE ITGB5

8.89e-05321554GO:0008305
GeneOntologyCellularComponentnuclear pore inner ring

NUP205 NUP155

1.63e-0431552GO:0044611
GeneOntologyCellularComponentinsulin receptor complex

INSR IGF1R

3.25e-0441552GO:0005899
GeneOntologyCellularComponentaxon

TANC2 PRTG KLHL24 INSR BCAN VPS16 ITGA2 KLHL20 TBC1D24 IGF1R GRK2 CNTN5 UHMK1 TANC1 VSTM5 ALDOC UNC80

3.40e-0489115517GO:0030424
DomainFBA_I

ALDOA ALDOB ALDOC

5.39e-0731533IPR000741
DomainGlycolytic

ALDOA ALDOB ALDOC

5.39e-0731533PF00274
DomainAldolase_I_AS

ALDOA ALDOB ALDOC

5.39e-0731533IPR029768
DomainALDOLASE_CLASS_I

ALDOA ALDOB ALDOC

5.39e-0731533PS00158
Domain-

WWC3 RASA3 INPP4A DYSF SYDE2 PLA2G4F CAPN5 CPNE7

3.02e-0514815382.60.40.150
DomainIntegrin_dom

ITGA2 ITGA5 ITGAE ITGB5

4.79e-05251534IPR032695
DomainC2_dom

WWC3 RASA3 INPP4A DYSF SYDE2 PLA2G4F CAPN5 CPNE7

6.27e-051641538IPR000008
DomainTyr_kinase_rcpt_2_CS

INSR IGF1R LTK

8.48e-05111533IPR002011
Domain-

PAPPA2 PRTG PSG3 INSR FSD2 BCAN HEPACAM2 ADAMTSL3 CD1E IGF1R CNTN5 PSG8 VSTM5 IL1RAP EPHA10 CD276

1.11e-04663153162.60.40.10
DomainRECEPTOR_TYR_KIN_II

INSR IGF1R LTK

1.12e-04121533PS00239
DomainC2

WWC3 RASA3 INPP4A DYSF PLA2G4F CAPN5 CPNE7

1.70e-041421537PS50004
DomainTyr_kinase_insulin-like_rcpt

INSR IGF1R

1.99e-0431532IPR016246
DomainIg-like_fold

PAPPA2 PRTG PSG3 INSR FSD2 BCAN HEPACAM2 ADAMTSL3 CD1E IGF1R CNTN5 PSG8 VSTM5 IL1RAP EPHA10 CD276

2.28e-0470615316IPR013783
DomainIntegrin_alpha_C_CS

ITGA2 ITGA5 ITGAE

2.79e-04161533IPR018184
DomainPPR

DENND4A DENND4C

3.96e-0441532PF01535
DomainIntegrin_alpha-2

ITGA2 ITGA5 ITGAE

4.02e-04181533IPR013649
DomainINTEGRIN_ALPHA

ITGA2 ITGA5 ITGAE

4.02e-04181533PS00242
DomainIntegrin_alpha2

ITGA2 ITGA5 ITGAE

4.02e-04181533PF08441
DomainIntegrin_alpha

ITGA2 ITGA5 ITGAE

4.02e-04181533IPR000413
DomainInt_alpha

ITGA2 ITGA5 ITGAE

4.74e-04191533SM00191
DomainInt_alpha_beta-p

ITGA2 ITGA5 ITGAE

4.74e-04191533IPR013519
DomainVWFA

ITGA2 ITGAE ITGB5 COL21A1 CPNE7

5.68e-04821535PS50234
DomainVWA

ITGA2 ITGAE ITGB5 COL21A1 CPNE7

6.34e-04841535SM00327
DomainFG_GAP

ITGA2 ITGA5 ITGAE

7.40e-04221533PS51470
DomainFN3

PAPPA2 PRTG INSR FSD2 IGF1R CNTN5 EPHA10

8.40e-041851537SM00060
DomainPentatricopeptide_repeat

DENND4A DENND4C PRKDC

8.46e-04231533IPR002885
DomainC2

RASA3 INPP4A DYSF PLA2G4F CAPN5 CPNE7

9.33e-041371536SM00239
DomainPeptidase_M12B_ADAM-TS

ADAMTSL3 ADAMTS7 ADAMTS20

9.62e-04241533IPR013273
DomainFG-GAP

ITGA2 ITGA5 ITGAE

9.62e-04241533PF01839
DomainFG-GAP

ITGA2 ITGA5 ITGAE

9.62e-04241533IPR013517
DomainVWF_A

ITGA2 ITGAE ITGB5 COL21A1 CPNE7

1.33e-03991535IPR002035
DomainRecep_L_domain

INSR IGF1R

1.36e-0371532PF01030
DomainFurin-like

INSR IGF1R

1.36e-0371532PF00757
DomainRcpt_L-dom

INSR IGF1R

1.36e-0371532IPR000494
DomainFurin-like_Cys-rich_dom

INSR IGF1R

1.36e-0371532IPR006211
Domain-

INSR IGF1R

1.36e-03715323.80.20.20
PathwayPID_INTEGRIN_CS_PATHWAY

ITGA2 ITGA5 ITGAE ITGB5

7.11e-05261234M47
PathwayREACTOME_GLUCOSE_METABOLISM

NUP88 NUP205 NUP155 ALDOA ALDOB ALDOC

7.96e-05821236MM15394
PathwayREACTOME_GLUCOSE_METABOLISM

NUP88 NUP205 NUP155 ALDOA ALDOB ALDOC

9.73e-05851236M1870
PathwayKEGG_FRUCTOSE_AND_MANNOSE_METABOLISM

ALDOA ALDOB ALDOC GMPPA

2.09e-04341234M15898
PathwayWP_INTEGRINMEDIATED_CELL_ADHESION

CAPN3 ITGA2 ITGA5 ITGAE ITGB5 CAPN5

2.66e-041021236M39577
PathwayWP_INTEGRINMEDIATED_CELL_ADHESION

CAPN3 ITGA2 ITGA5 ITGAE ITGB5 CAPN5

2.66e-041021236MM15830
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

CAPN3 BCAN ITGA2 ITGA5 ITGAE ITGB5 EFEMP1 COL21A1 NID1 CAPN5

2.95e-0430012310M610
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TANC2 DOCK3 PGAP3 EP400 RASA3 KIF26A ITGA5 DYSF GBA2 ITGB5 TBC1D24 RADIL IGF1R ADAMTS7 PI4KA EXOSC6 LRRC56 TANC1 DTX2 PRKDC LTK SIPA1L2 CD276

9.84e-1011051562335748872
Pubmed

Mode of interactions of human aldolase isozymes with cytoskeletons.

ALDOA ALDOB ALDOC

8.85e-08315639244396
Pubmed

Aldolase positively regulates of the canonical Wnt signaling pathway.

ALDOA ALDOB ALDOC

8.85e-083156324993527
Pubmed

Human skeletal-muscle aldolase: N-terminal sequence analysis of CNBr- and o-iodosobenzoic acid-cleavage fragments.

ALDOA ALDOB ALDOC

8.85e-08315636696436
Pubmed

Family-based analysis of candidate genes for polycystic ovary syndrome.

ENPP1 INSR FEM1B IGF1R CAPN5

1.27e-0727156520200332
Pubmed

Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump.

ALDOA ALDOB ALDOC

3.53e-074156311399750
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

DSC2 RASA3 INSR OCRL ITGA2 TBC1D24 IGF1R NUP155 PI4KA EFR3B SIPA1L2 GAB1

4.96e-074211561236976175
Pubmed

Integrin requirement for hippocampal synaptic plasticity and spatial memory.

ITGA2 ITGA5 ITGAE ITGB5

6.80e-0716156412904471
Pubmed

Probing nuclear pore complex architecture with proximity-dependent biotinylation.

NUP88 CSMD3 NUP205 CD1E NUP155 PRKDC

1.35e-0677156624927568
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

TRHDE PAPPA2 DSC2 MUC5B DYSF ITGB5 FCGBP EFEMP1 RNH1 UGDH NID1 CAPN5 ALDOA ALDOB ALDOC GMPPA DOP1B CPNE7

1.65e-0610701561823533145
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

DNAJC13 DSC2 EP400 INSR RNF213 OCRL KIF20A NUP155 PI4KA SYDE2 UGDH PRKDC ALDOA TARS1 GAB1

2.46e-067771561535844135
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

DNAJC13 EP400 RASA3 OCRL VPS16 ECM1 NUP205 KIF20A EIF2D NUP155 RNH1 FDPS PI4KA CHTF18 VPS35 UGDH TANC1 PRKDC ALDOA TARS1

3.01e-0613531562029467282
Pubmed

Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.

ITGA2 ITGA5 ITGAE ITGB5

6.31e-0627156431541017
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

TANC2 IPO5 DNAJC13 INPP4A DAPK1 BCAN ITGA2 ECI1 TBC1D24 MLIP AGO1 GRK2 PI4KA VPS35 TANC1 SIPA1L2 ALDOA ALDOC TARS1 DNAH11

6.90e-0614311562037142655
Pubmed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.

PRTG PSG3 HEPACAM2 CNTN5 PSG8 VSTM5 IL1RAP

9.09e-06162156725826454
Pubmed

Heterodimerization of glycosylated insulin-like growth factor-1 receptors and insulin receptors in cancer cells sensitive to anti-IGF1R antibody.

INSR IGF1R

2.00e-052156222438913
Pubmed

Cutaneous inflammatory disorder in integrin alphaE (CD103)-deficient mice.

ITGAE PRKDC

2.00e-052156211086102
Pubmed

Insulin and IGF-1 have both overlapping and distinct effects on CD4+ T cell mitochondria, metabolism, and function.

INSR IGF1R

2.00e-052156238383709
Pubmed

Oncogenic functions of IGF1R and INSR in prostate cancer include enhanced tumor growth, cell migration and angiogenesis.

INSR IGF1R

2.00e-052156224809298
Pubmed

A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis.

INSR IGF1R

2.00e-052156221139139
Pubmed

The insulin and IGF1 receptor kinase domains are functional dimers in the activated state.

INSR IGF1R

2.00e-052156225758790
Pubmed

Structure and expression of mouse aldolase genes. Brain-specific aldolase C amino acid sequence is closely related to aldolase A.

ALDOA ALDOC

2.00e-05215623009179
Pubmed

Compounds from the marine sponge Cribrochalina vasculum offer a way to target IGF-1R mediated signaling in tumor cells.

INSR IGF1R

2.00e-052156227384680
Pubmed

Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart.

INSR IGF1R

2.00e-052156235786404
Pubmed

Insulin-Mediated Signaling Facilitates Resistance to PDGFR Inhibition in Proneural hPDGFB-Driven Gliomas.

INSR IGF1R

2.00e-052156228138037
Pubmed

Thyrocyte-specific deletion of insulin and IGF-1 receptors induces papillary thyroid carcinoma-like lesions through EGFR pathway activation.

INSR IGF1R

2.00e-052156230070361
Pubmed

Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes.

INSR IGF1R

2.00e-052156231562314
Pubmed

Aldolase-B knockout in mice phenocopies hereditary fructose intolerance in humans.

ALDOA ALDOB

2.00e-052156225637246
Pubmed

Insulin-like growth factor I receptors are more abundant than insulin receptors in human micro- and macrovascular endothelial cells.

INSR IGF1R

2.00e-052156214722023
Pubmed

Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance.

INSR IGF1R

2.00e-052156217416680
Pubmed

Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling.

INSR IGF1R

2.00e-052156222692545
Pubmed

Integrin αvβ5 heterodimer is a specific marker of human pancreatic beta cells.

ITGA5 ITGB5

2.00e-052156233859325
Pubmed

High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy.

INSR IGF1R

2.00e-052156221177763
Pubmed

Changes in insulin and IGF-I receptor expression during differentiation of human preadipocytes.

INSR IGF1R

2.00e-052156218693051
Pubmed

Expression of the pregnancy-specific beta 1-glycoprotein genes in human testis.

PSG3 PSG8

2.00e-05215622302228
Pubmed

Insulin/IGF-1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet function.

INSR IGF1R

2.00e-052156219817984
Pubmed

Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy.

INSR IGF1R

2.00e-052156219744489
Pubmed

Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor.

INSR IGF1R

2.00e-052156228065828
Pubmed

Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior.

INSR IGF1R

2.00e-052156230765523
Pubmed

Functional collaboration of insulin-like growth factor-1 receptor (IGF-1R), but not insulin receptor (IR), with acute GH signaling in mouse calvarial cells.

INSR IGF1R

2.00e-052156224302626
Pubmed

Novel nuclear localization and potential function of insulin-like growth factor-1 receptor/insulin receptor hybrid in corneal epithelial cells.

INSR IGF1R

2.00e-052156222879999
Pubmed

Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling.

INSR IGF1R

2.00e-052156236548088
Pubmed

Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function.

INSR IGF1R

2.00e-052156217189427
Pubmed

Mesothelium expression of integrins in vivo and in vitro.

ITGA2 ITGA5

2.00e-05215629509387
Pubmed

Fibulin-3-mediated inhibition of epithelial-to-mesenchymal transition and self-renewal of ALDH+ lung cancer stem cells through IGF1R signaling.

IGF1R EFEMP1

2.00e-052156224013232
Pubmed

[Effects of insulin on expression of insulin receptor and insulin-like growth factor-1 receptor and proliferation in Reh cells].

INSR IGF1R

2.00e-052156222541124
Pubmed

A functional assessment of insulin/insulin-like growth factor-I hybrid receptors.

INSR IGF1R

2.00e-05215627895674
Pubmed

Insulin receptor and IGF1R are not required for oocyte growth, differentiation, and maturation in mice.

INSR IGF1R

2.00e-052156219851056
Pubmed

Combined and individual tumor-specific expression of insulin-like growth factor-I receptor, insulin receptor and phospho-insulin-like growth factor-I receptor/insulin receptor in primary breast cancer: Implications for prognosis in different treatment groups.

INSR IGF1R

2.00e-052156228030849
Pubmed

Insulin-like growth factor type 1 receptor and insulin receptor isoform expression and signaling in mammary epithelial cells.

INSR IGF1R

2.00e-052156219406949
Pubmed

Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis.

INSR IGF1R

2.00e-052156227905925
Pubmed

Protein studies in dysferlinopathy patients using llama-derived antibody fragments selected by phage display.

CAPN3 DYSF

2.00e-052156215827562
Pubmed

Placental glycogen stores are increased in mice with H19 null mutations but not in those with insulin or IGF type 1 receptor mutations.

INSR IGF1R

2.00e-052156219524295
Pubmed

Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation.

INSR IGF1R

2.00e-052156218650937
Pubmed

A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding.

INSR IGF1R

2.00e-052156230213860
Pubmed

Epithelial-mesenchymal transition predicts sensitivity to the dual IGF-1R/IR inhibitor OSI-906 in hepatocellular carcinoma cell lines.

INSR IGF1R

2.00e-052156222161861
Pubmed

Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity.

INSR IGF1R

2.00e-052156229040448
Pubmed

A novel approach to identify two distinct receptor binding surfaces of insulin-like growth factor II.

INSR IGF1R

2.00e-052156219139090
Pubmed

Apolipoprotein C3 and circulating mediators of preadipocyte proliferation in states of lipodystrophy.

INSR IGF1R

2.00e-052156235964946
Pubmed

Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization.

INSR IGF1R

2.00e-052156212813019
Pubmed

Epigenetic DNA methylation in the promoters of the Igf1 receptor and insulin receptor genes in db/db mice.

INSR IGF1R

2.00e-052156221474992
Pubmed

Endothelial Cell Mediated Promotion of Ciliated Cell Differentiation of Human Airway Basal Cells via Insulin and Insulin-Like Growth Factor 1 Receptor Mediated Signaling.

INSR IGF1R

2.00e-052156228050756
Pubmed

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.

INSR IGF1R

2.00e-052156216642022
Pubmed

IGF1R Expression in Ovarian Granulosa Cells Is Essential for Steroidogenesis, Follicle Survival, and Fertility in Female Mice.

INSR IGF1R

2.00e-052156228407051
Pubmed

BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis.

INSR IGF1R

2.00e-052156226438154
Pubmed

Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.

INSR IGF1R

2.00e-052156223671263
Pubmed

Partial dysferlin reconstitution by adult murine mesoangioblasts is sufficient for full functional recovery in a murine model of dysferlinopathy.

DYSF PRKDC

2.00e-052156221364666
Pubmed

Suppression of Cardiac Autophagy by Hyperinsulinemia in Insulin Receptor-Deficient Hearts Is Mediated by Insulin-Like Growth Factor Receptor Signaling.

INSR IGF1R

2.00e-052156231088290
Pubmed

Development of a Quantitative PCR Assay for Detection of Human Insulin-Like Growth Factor Receptor and Insulin Receptor Isoforms.

INSR IGF1R

2.00e-052156226862994
Pubmed

Human microvascular endothelial cells are sensitive to IGF-I but resistant to insulin at the receptor level.

INSR IGF1R

2.00e-052156218708119
Pubmed

Role of insulin receptor in the regulation of glucose uptake in neonatal hepatocytes.

INSR IGF1R

2.00e-052156216644916
Pubmed

The signaling potential of the receptors for insulin and insulin-like growth factor I (IGF-I) in 3T3-L1 adipocytes: comparison of glucose transport activity, induction of oncogene c-fos, glucose transporter mRNA, and DNA-synthesis.

INSR IGF1R

2.00e-05215621660482
Pubmed

Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes.

INSR IGF1R

2.00e-052156225246545
Pubmed

Lipodystrophy Due to Adipose Tissue-Specific Insulin Receptor Knockout Results in Progressive NAFLD.

INSR IGF1R

2.00e-052156227207510
Pubmed

Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function.

INSR IGF1R

2.00e-052156227207537
Pubmed

Reduced insulin-like growth factor I receptor and altered insulin receptor isoform mRNAs in normal mucosa predict colorectal adenoma risk.

INSR IGF1R

2.00e-052156225017244
Pubmed

Differential expression of IGF-I and insulin receptor isoforms in HPV positive and negative human cervical cancer cell lines.

INSR IGF1R

2.00e-052156218711691
Pubmed

Differential Expression of IR-A, IR-B and IGF-1R in Endometrial Physiology and Distinct Signature in Adenocarcinoma.

INSR IGF1R

2.00e-052156227088794
Pubmed

Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase.

DAPK1 KLHL20

2.00e-052156231279627
Pubmed

Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit.

ENPP1 INSR

2.00e-052156210615944
Pubmed

Preclinical and first-in-human phase I studies of KW-2450, an oral tyrosine kinase inhibitor with insulin-like growth factor receptor-1/insulin receptor selectivity.

INSR IGF1R

2.00e-052156226850678
Pubmed

Insulin, insulin receptor and insulin-like growth factor-I receptor on the human ocular surface.

INSR IGF1R

2.00e-052156212613967
Pubmed

Signalling through the insulin receptor and the insulin-like growth factor-I receptor.

INSR IGF1R

2.00e-05215627821728
Pubmed

A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer.

INSR IGF1R

2.00e-052156221908557
Pubmed

Obesity and intestinal epithelial deletion of the insulin receptor, but not the IGF 1 receptor, affect radiation-induced apoptosis in colon.

INSR IGF1R

2.00e-052156226251471
Pubmed

Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis.

INSR IGF1R

2.00e-052156225981038
Pubmed

Differential effects of IGF-I, IGF-II and insulin in human preadipocytes and adipocytes--role of insulin and IGF-I receptors.

INSR IGF1R

2.00e-052156221524684
Pubmed

Insulin and IGF1 receptors in human cardiac microvascular endothelial cells: metabolic, mitogenic and anti-inflammatory effects.

INSR IGF1R

2.00e-052156222825921
Pubmed

Expression of GRK2 and IGF1R in hepatocellular carcinoma: clinicopathological and prognostic significance.

IGF1R GRK2

2.00e-052156228202495
Pubmed

Targeting Insulin Receptor in Breast Cancer Using Small Engineered Protein Scaffolds.

INSR IGF1R

2.00e-052156228468775
Pubmed

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change.

INSR IGF1R

2.00e-052156219835884
Pubmed

Immunolocalization of alpha 2, alpha 5, and alpha 6 integrin subunits in salivary tissue and adenomas of the parotid gland.

ITGA2 ITGA5

2.00e-05215627861330
Pubmed

The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121).

ENPP1 INSR

2.00e-052156211289049
Pubmed

Absence of T and B lymphocytes modulates dystrophic features in dysferlin deficient animal model.

DYSF PRKDC

2.00e-052156222465227
Pubmed

The expression and role of hybrid insulin/insulin-like growth factor receptor type 1 in endometrial carcinoma cells.

INSR IGF1R

2.00e-052156220620597
Pubmed

Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood-brain barrier.

INSR IGF1R

2.00e-052156215063759
Pubmed

Genotype-Structure-Phenotype Correlations of Disease-Associated IGF1R Variants and Similarities to Those of INSR Variants.

INSR IGF1R

2.00e-052156234074726
Pubmed

Fructose-1,6-Bisphosphate Aldolase B Depletion Promotes Hepatocellular Carcinogenesis Through Activating Insulin Receptor Signaling and Lipogenesis.

INSR ALDOB

2.00e-052156234292642
Pubmed

Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins.

TANC2 TANC1

2.00e-052156221068316
Pubmed

IGF-I and insulin activate mitogen-activated protein kinase via the type 1 IGF receptor in mouse embryonic stem cells.

INSR IGF1R

2.00e-052156217641087
GeneFamilyCD molecules|Integrin alpha subunits

ITGA2 ITGA5 ITGAE

1.54e-041810731160
GeneFamilyFibronectin type III domain containing

PRTG INSR FSD2 IGF1R CNTN5 EPHA10

3.78e-041601076555
GeneFamilyAdenosine receptors|V-set domain containing

PSG3 BCAN HEPACAM2 PSG8 VSTM5 CD276

4.18e-041631076590
GeneFamilyNucleoporins

NUP88 NUP205 NUP155

8.82e-043210731051
GeneFamilyBEN domain containing

BEND4 BEND2

1.22e-0391072422
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

INPP4A SYDE2 CAPN5

1.25e-03361073823
GeneFamilyReceptor Tyrosine Kinases|CD molecules

INSR IGF1R LTK

1.70e-03401073321
GeneFamilyCD molecules|V-set domain containing|Pregnancy specific glycoproteins

PSG3 PSG8

1.84e-031110721315
GeneFamilyKinesins|Pleckstrin homology domain containing

KIF26A KIF7 KIF20A

2.54e-03461073622
GeneFamilyC2 domain containing|Calpains

CAPN3 CAPN5

3.46e-03151072975
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

PAPPA2 BCAN CSMD3

4.68e-035710731179
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS7 ADAMTS20

5.56e-0319107250
CoexpressionGSE6875_WT_VS_FOXP3_KO_TREG_UP

DNAJC13 RASA3 SMC5 MOXD1 AGO1 GRK2 FDPS PI4KA GAB1

3.15e-062001559M6803
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRHDE MUC5B CSMD3 RYR3 ADAMTS20 MYH15 UNC80 EPHA10 DNAH11

1.87e-0818415692cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRHDE MUC5B CSMD3 RYR3 ADAMTS20 MYH15 UNC80 EPHA10 DNAH11

1.87e-081841569ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRHDE MUC5B CSMD3 RYR3 ADAMTS20 MYH15 UNC80 EPHA10 DNAH11

1.87e-0818415692b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA5 ADAMTSL3 ECM1 ITGB5 EFEMP1 SLIT3 UGDH NID1 GPNMB

2.05e-081861569a7ab70b049742dfe7ee30557031bfac6412edf52
ToppCell3'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRHDE DAPK1 HEPACAM2 ITGB5 LRRC56 KLHDC7A KLK13 ABHD16A

2.36e-071791568906555ce2ca264a0215b120c7ff7c9b411de6a34
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

INPP4A HEPACAM2 ADAMTSL3 CSMD3 DOP1B CPNE7 DNAH11

8.52e-071461567ec1f793409d1a81c0f9323eb3c82ffe01dae0e44
ToppCell356C-Lymphocytic-NK_cells-NK_cell_E|356C / Donor, Lineage, Cell class and subclass (all cells)

INPP4A CDIN1 UBAP1 CEP76 GBA2 ABHD16A CPNE7

1.86e-061641567d5bb57c321f2973836efc8990449494cc1fb87c7
ToppCell356C-Lymphocytic-NK_cells-NK_cell_E|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

INPP4A CDIN1 UBAP1 GBA2 SLC9A7 ABHD16A CPNE7

2.75e-061741567a79ebb01a5849c314e02594a9c95009dbb03cb8c
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE BEND4 RYR3 SYDE2 CNTN5 IL1RAP GAB1

2.75e-061741567ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCelldroplet-Bladder-nan-24m-Epithelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF20A RADIL EFEMP1 NPC1L1 SLIT3 LTK UNC80

3.32e-061791567dfd9d29281510d32f1a2e8336d2e58ef496cfd1d
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAPK1 PNPLA5 NUP205 KIF20A SYDE2 GPNMB POLQ

3.98e-06184156716aa8e88bdd51b1d132d5cf33c29963b384a8bae
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

CDIN1 RNF213 NUP155 MCM9 PRKDC POLQ DOP1B

4.12e-061851567a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL3 ECM1 EFEMP1 SLIT3 UGDH NID1 GPNMB

4.27e-061861567ff6ccfdf2509f96caa10281c29a95b432f6c6dcc
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

CDIN1 RNF213 NUP155 MCM9 PRKDC POLQ DOP1B

4.27e-0618615678571956890fc9894d766ba294a28e376b4aba428
ToppCellfacs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM1 PMEPA1 EFEMP1 SLIT3 NID1 GPNMB CPNE7

4.42e-061871567f3ef3f5a761f8306edc39bf16e76e44aae6fa7f6
ToppCellfacs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM1 PMEPA1 EFEMP1 SLIT3 NID1 GPNMB CPNE7

4.42e-0618715671669df899b1759c338ffce196fe009840123cfcd
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACKR4 ECM1 TSPAN5 EFEMP1 SLIT3 UGDH NID1

4.58e-061881567aa516273cdde53c8c0295f06830972388f890c97
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 PAPPA2 DAPK1 RGS11 DENND4C RYR3 EFEMP1

4.74e-061891567e059be2965cca70ff5576df055d0af1775b76e00
ToppCelldroplet-Limb_Muscle-nan-18m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK3 BCAN PEX11A CSMD3 MLIP KLK13 UNC80

4.91e-061901567e2481bd5166fde2cdc0c3824894f2bccb8294fdd
ToppCell5'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRHDE TANC2 DAPK1 HEPACAM2 LRRC56 KLHDC7A KLK13

5.08e-06191156754f07e4de61735051498846afb44b1798bed8144
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE ENPP1 DAPK1 ADAMTSL3 COL21A1 ADAMTS20 TANC1

5.08e-0619115679c0ee270209b02043393416ecc9a81ddedfbb8b6
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-goblet|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MUC5B HEPACAM2 FCGBP PLA2G4F CAPN5 LTK DOP1B

5.44e-061931567402aad2f9e789ad1f2e1536cdc9ce61de7625427
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE ENPP1 DAPK1 ADAMTSL3 MOXD1 COL21A1 TANC1

5.44e-0619315672c15186d15545804cc262da9137ab825609d4b2c
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MUC5B HEPACAM2 FCGBP PLA2G4F CAPN5 LTK DOP1B

5.44e-0619315677ee3b1ef5c455f321b4e154ae62c69543fe9b30e
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE PRTG ADAMTSL3 ITGB5 COL21A1 ADAMTS20 TANC1

5.44e-061931567e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Mesenchymal-mesenchymal_stem_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL3 ECM1 ITGB5 EFEMP1 SLIT3 UGDH NID1

5.44e-061931567160691b671710be10220803d788c2c961c236af1
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACKR4 ADAMTSL3 ECM1 EFEMP1 SLIT3 UGDH NID1

5.63e-0619415677b6ec45adb7ece3c8a7b78c5782413b5825effe2
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE PRTG DAPK1 ADAMTSL3 ITGB5 COL21A1 TANC1

5.63e-0619415671bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCellfacs-Heart-LA|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM1 PMEPA1 ITGB5 NDFIP1 NID1 GPNMB CPNE7

6.02e-0619615678a84aeb1a565dd3e2a690fcaf1ab804f5e253545
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACKR4 ADAMTSL3 ECM1 EFEMP1 SLIT3 UGDH NID1

6.02e-061961567ed6047b48b6a96baa6a90c7af784e7c34b32824d
ToppCellCOVID-19-COVID-19_Mild-Myeloid-immature_Neutrophil|COVID-19_Mild / Disease, condition lineage and cell class

DYSF ECM1 KIF20A SUV39H1 TANC1 POLQ ALDOA

6.65e-061991567e222b90caf45904d8f763574e7b6aac13333df92
ToppCell(5)_Fibroblast-F|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

ACKR4 ADAMTSL3 ECM1 EFEMP1 SLIT3 UGDH CAPN5

6.65e-0619915671f66db4f502de4a5159cde90fcb3befb26b8d375
ToppCelldistal-mesenchymal|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ADAMTSL3 ECM1 MOXD1 EFEMP1 COL21A1 SLIT3 NID1

6.87e-062001567b54137a4545690f51e154bb05964eaa650c3ca8e
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TRHDE ITGA2 ADAMTSL3 MOXD1 COL21A1 SLIT3 NID1

6.87e-06200156734f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

E2F7 BEND2 SLC7A3 ADAMTS7 NKPD1 POLQ

1.80e-051551566969fc4c98a96bf2f436e8e63d4deb2183ef3b864
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRHDE CECR2 MUC5B RYR3 MYH15 UNC80

2.15e-051601566c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRHDE CECR2 MUC5B RYR3 MYH15 UNC80

2.15e-05160156625c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRHDE DOCK3 SFXN4 NDFIP1 CHTF18 SLIT3

2.23e-0516115665fba13f0aa5002f7eefe219e2c6a07e163f1a50d
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRHDE TANC2 HEPACAM2 LRRC56 KLHDC7A KLK13

2.83e-0516815668072d0496b7b730c4601009eaa69ec5366d26d73
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACKR4 RADIL EFEMP1 SLIT3 NID1 GPNMB

2.93e-051691566bb43abad2c049b7f4d307737347290e01b3339a3
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACKR4 RADIL EFEMP1 SLIT3 NID1 GPNMB

2.93e-0516915665f18e3f40a5b1b167903f37516ec8181e889c7c5
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACKR4 RADIL EFEMP1 SLIT3 NID1 GPNMB

2.93e-0516915668bfa2d3bb541d02f55d7c95b8fd156c8403befca
ToppCellAdult-Mesenchymal-pericyte_cell-D231|Adult / Lineage, Cell type, age group and donor

BEND2 ADAMTSL3 ECM1 SLIT3 NID1 ABHD16A

3.23e-051721566858cee96c1c06160863b4adcd7023c0d678bd50f
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PGAP3 ENPP1 CEP76 ACKR4 ITGAE SLC9A7

3.34e-0517315668bffd512a4e561e23cc04478e2ca6fd5d3771fe4
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PGAP3 ENPP1 CEP76 ACKR4 ITGAE SLC9A7

3.34e-0517315663e3c61468e703330788a10d850ef41a85680f86d
ToppCellAdult-Epithelial-lung_goblet_cell-D231|Adult / Lineage, Cell type, age group and donor

INSR MUC5B HEPACAM2 FCGBP MLIP KLK13

3.45e-0517415667d2f802f493f19a068e097b2909a9000e2160266
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRTG INSR FCGBP UGDH DTX2 KLK13

3.56e-051751566dbd9dac129fb6ae5f55e7b96d04b37585458dc4a
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BEND4 ITGA5 HESX1 CHTF18 GAB1 DNAH11

3.68e-0517615663766e0533b103ec92ac75eba3df02e287efc53fa
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BEND4 ITGA5 HESX1 CHTF18 GAB1 DNAH11

3.68e-051761566aa1bada2175d8370fc71939a607407155259d195
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

E2F7 ITGA5 DYSF KIF20A NID1 POLQ

3.80e-05177156673ba0f0b4b33f10e9f036d6d9befa48a1258e682
ToppCell21-Trachea-Epithelial-Submucosal_gland|Trachea / Age, Tissue, Lineage and Cell class

DSC2 INSR FSD2 MUC5B SLIT3 VSTM5

3.92e-0517815663e406e38eea0d38dc25edecf703c4c89ec6a28e0
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

INPP4A HEPACAM2 ADAMTSL3 CSMD3 DOP1B DNAH11

4.17e-051801566cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ENPP1 ACKR4 ECM1 PMEPA1 KIF7 NID1

4.17e-051801566935c091bbcd6d10b81dc4731779e5bd98205c99f
ToppCellLV|World / Chamber and Cluster_Paper

KLHL24 CDIN1 FSD2 NHLRC2 MLIP GAB1

4.17e-0518015665ac6f485a58bb29462fec02dfbe8eb70864eafe3
ToppCell5'-Airway_Nasal-Mesenchymal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ENPP1 ACKR4 ECM1 PMEPA1 KIF7 NID1

4.17e-0518015663dd384b7f3d9582b8fec9fe05100e466e6218b76
ToppCell5'-Adult-Appendix-Neuronal-Glial_mature|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RGS11 BCAN MOXD1 ADAMTS7 COL21A1 DNAH11

4.30e-0518115663aa81ac64d0cc9a74fbfa71e2176740548e7cd06
ToppCell5'-Adult-Appendix-Neuronal-Glial_mature-Adult_Glia|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RGS11 BCAN MOXD1 ADAMTS7 COL21A1 DNAH11

4.30e-051811566997ba1be2824b00d684f2163d0114656ed11fa53
ToppCellfacs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACKR4 ECM1 RADIL EFEMP1 UGDH NID1

4.30e-051811566c7f5aedcb74c21fb587a95a16d700e2a38a380ee
ToppCellfacs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACKR4 ECM1 RADIL EFEMP1 UGDH NID1

4.30e-0518115660ec9621a078d004bbd25a587757d24b5cf162959
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 KIF26A DYSF ADAMTS20 CAPN5 CD276

4.30e-0518115667af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCell5'-Adult-Appendix-Neuronal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RGS11 BCAN MOXD1 ADAMTS7 COL21A1 DNAH11

4.30e-051811566e6b7e8dd5c13cc10ba22f2f5a8c669486f934bdc
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-club_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK3 PGAP3 MUC5B MOXD1 PLA2G4F PADI1

4.30e-0518115664a0f1b121570430afb100c589657d931184e124f
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-club_cell-club_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK3 PGAP3 MUC5B MOXD1 PLA2G4F PADI1

4.30e-05181156634b49092f71128898af3b311170c4ed8adfefcff
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ENPP1 ACKR4 ECM1 PMEPA1 KIF7 NID1

4.57e-051831566803376f5260de83c48d4f7301278d078a32b3e6e
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ENPP1 ACKR4 ECM1 PMEPA1 KIF7 NID1

4.57e-0518315666d98973098c6d20c5305bce6a83a549a7d8dbfba
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ENPP1 ACKR4 ECM1 PMEPA1 KIF7 NID1

4.57e-051831566cc7f5a17b40e8d901885174922e5fa8877643071
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PAPPA2 DSC2 ECM1 TSPAN5 EFEMP1 ALDOC

4.57e-051831566274f274cf60daa30d6a4cd603a3af7823bfb8016
ToppCelldroplet-Limb_Muscle-nan-21m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA2 CSMD3 MLIP POLQ KLK13 UNC80

4.86e-0518515663d1353dbcb60e2531ef67e1bd218b7bc4d7c7c9b
ToppCelldroplet-Limb_Muscle-nan-21m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA2 CSMD3 MLIP POLQ KLK13 UNC80

4.86e-051851566995a8ddc3fd8e6879d8b5de8cbdefe232d34833b
ToppCellIPF-Myeloid-DC_Langerhans|Myeloid / Disease state, Lineage and Cell class

ENPP1 ZNF710 CD1E FCGBP SLIT3 SLC9A7

4.86e-051851566ced17f69486591c3cbbdc852a3e82c3f3a4a30d7
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DAPK1 DYSF ECM1 IGF1R GPNMB SIPA1L2

5.00e-051861566f73cb91e74a806858650ae97f543fc779ba4cff8
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DAPK1 DYSF ECM1 IGF1R GPNMB SIPA1L2

5.00e-0518615668694ca16c9780729f4fba67ba20e35745f1eb4e9
ToppCellfacs-Heart-LA-24m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM1 EFEMP1 SLIT3 NID1 GPNMB CPNE7

5.00e-051861566ed0a91f47e77fe21d4c7678d0f2a7c5f97d63dda
ToppCellfacs-Trachea-nan-24m-Mesenchymal|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM1 EFEMP1 SLIT3 UGDH NID1 GPNMB

5.16e-05187156671385068e3fd0bfa7822ae176113a49460c8636b
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACKR4 ECM1 RADIL SLIT3 UGDH NID1

5.16e-0518715660d4b7da81036c2aa678654b9fe49c939d08fcd9b
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL3 ECM1 EFEMP1 SLIT3 NID1 GPNMB

5.16e-0518715664e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL3 ECM1 EFEMP1 SLIT3 NID1 GPNMB

5.16e-051871566d36e7fc6125e7a4310499365022d38f34b757a73
ToppCellfacs-Trachea-nan-24m-Mesenchymal-fibroblast|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM1 EFEMP1 SLIT3 UGDH NID1 GPNMB

5.16e-051871566b930d5f7d410ac1f340babec5c937388f64cafc0
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL3 ECM1 EFEMP1 SLIT3 NID1 GPNMB

5.16e-051871566827eae63fabf6892a82ce7779b5f395958d3d628
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSMD3 MLIP ADAMTS20 IL1RAP KLK13 UNC80

5.16e-051871566a0bd2b0ec9e73521c245037b1dd51ff8cf24cbf5
ToppCellfacs-Trachea-nan-24m-Mesenchymal-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM1 EFEMP1 SLIT3 UGDH NID1 GPNMB

5.16e-051871566e891e571f6bb9433a0046215de6cabd89ed1effc
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSMD3 MLIP ADAMTS20 IL1RAP KLK13 UNC80

5.16e-051871566f2af79a20438108c814a73f9e24cd986d537237f
ToppCellRV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

DOCK3 KLHL24 CDIN1 FSD2 MLIP GAB1

5.16e-05187156678cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCellfacs-Bladder-nan-24m-Epithelial-bladder_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACKR4 ADAMTSL3 ECM1 EFEMP1 SLIT3 NID1

5.16e-0518715662c145e9d11424939dd99012a8cedf5d998b966e9
ToppCelldroplet-Limb_Muscle-nan-18m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK3 CSMD3 MLIP ADAMTS20 IL1RAP UNC80

5.31e-0518815668385fd384fc55e3b17802bb6698eb93b2c16d7f2
ToppCelldroplet-Limb_Muscle-nan-18m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK3 CSMD3 MLIP ADAMTS20 IL1RAP UNC80

5.31e-051881566cb9d0b48e2fd9cc576132803273b9c0382900944
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

DOCK3 KLHL24 CDIN1 FSD2 MLIP GAB1

5.47e-0518915669c1debd65c13d63fd4f3158917d621b44b714c26
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA5 ECM1 EFEMP1 SLIT3 UGDH NID1

5.63e-051901566bd0d68dc1b6f388190a6ba8a83b011619abe2bdd
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA5 ECM1 EFEMP1 SLIT3 UGDH NID1

5.63e-051901566e275de94468872e70cf305b3b450823d4c9c5e3f
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA5 ECM1 EFEMP1 SLIT3 UGDH NID1

5.63e-051901566ee2f4a55d2fd18b83e55399b5b5697a15a2d2e70
ToppCelldroplet-Limb_Muscle-nan-24m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM1 EFEMP1 SLIT3 UGDH NID1 GPNMB

5.63e-051901566ad0f5605db6b694445ec9bd5dc8d2d834358c0f9
ToppCelldroplet-Limb_Muscle-nan-24m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM1 EFEMP1 SLIT3 UGDH NID1 GPNMB

5.80e-05191156683d1915835df6f2eb23f87986d695e71398edb9d
ToppCelldroplet-Mammary_Gland-nan-18m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM1 EFEMP1 SLIT3 UGDH NID1 GPNMB

5.80e-051911566a57cf0519d749febc0b69fe0b098b7ba53d63258
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

RNF213 NUP155 MCM9 PRKDC POLQ DOP1B

5.80e-0519115669454f642c3621370fa23640b631301346b300950
ToppCelldroplet-Mammary_Gland-nan-18m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM1 EFEMP1 SLIT3 UGDH NID1 GPNMB

5.80e-05191156619c67a812b8ce97472d316acd15aeefe8736000d
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ITGA2 ADAMTSL3 MOXD1 COL21A1 SLIT3 NID1

5.80e-0519115666688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCellLV-04._Ventricular_Cardiomyocyte_I|LV / Chamber and Cluster_Paper

DOCK3 KLHL24 CDIN1 FSD2 MLIP TANC1

5.97e-051921566ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ECM1 EFEMP1 SLIT3 UGDH NID1 GPNMB

5.97e-051921566fc940f91ff8e051631dbf25e6e8d73cf8337eccb
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA5 ECM1 ITGB5 SLIT3 UGDH NID1

5.97e-051921566beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ITGA2 ADAMTSL3 MOXD1 COL21A1 SLIT3 NID1

5.97e-05192156699ce9e3c4c50cf64ebb62145f2b5420efa0db309
ComputationalGenes in the cancer module 412.

ITGA2 ITGA5 ITGAE ITGB5

3.39e-0613924MODULE_412
ComputationalGenes in the cancer module 275.

ITGA2 ITGA5 ITGAE ITGB5

8.45e-0616924MODULE_275
Drugchloroacetol phosphate

UGDH ALDOA ALDOB ALDOC

3.15e-0861564CID000168137
Drugacetol phosphate

ALDOA ALDOB ALDOC

3.16e-0731563CID000150865
Drug4-hydroxy-9-fluorenone

ALDOA ALDOB ALDOC

3.16e-0731563CID000016139
DrugHtfp

ALDOA ALDOB ALDOC

3.16e-0731563CID000125055
DrugDIDIT

ALDOA ALDOB ALDOC

3.16e-0731563CID000196082
Drug2-keto-3-deoxy- l-lyxonate

ALDOA ALDOB ALDOC

3.16e-0731563CID000192781
Drugandroisoxazole

ALDOA ALDOB ALDOC

3.16e-0731563CID000009676
Drug2-keto-3-bromobutyrate

ALDOA ALDOB ALDOC

3.16e-0731563CID000191968
Drug3-isochromanone

ALDOA ALDOB ALDOC

3.16e-0731563CID000078092
Drug5-deoxy-5-fluoro-L-sorbose

ALDOA ALDOB ALDOC

3.16e-0731563CID000191809
DrugD-ribulose-1-p

ALDOA ALDOB ALDOC

3.16e-0731563CID000000615
Drug4-hydroxy-2-ketopimelate

ALDOA ALDOB ALDOC

3.16e-0731563CID000000553
DrugAC1L19F1

ALDOA ALDOB ALDOC

3.16e-0731563CID000000519
Drugformylacetate

ALDOA ALDOB ALDOC

1.26e-0641563CID000075269
Drugdihydroxyacetone sulfate

ALDOA ALDOB ALDOC

1.26e-0641563CID000439751
DrugC06441

ALDOA ALDOB ALDOC

1.26e-0641563CID000441020
Drug3-hydroxy-1-indanone

ALDOA ALDOB ALDOC

1.26e-0641563CID000176448
Drugl-123

ALDOA ALDOB ALDOC

1.26e-0641563CID000093552
Drug1,3-dioxan-5-one

ALDOA ALDOB ALDOC

3.12e-0651563CID009793707
DrugAC1L4F2K

ALDOA ALDOB ALDOC

3.12e-0651563CID000184526
Druggamma-oxalocitramalate

ALDOA ALDOB ALDOC

3.12e-0651563CID000000130
Drug2,3-dihydroxy-p-cumate

ALDOA ALDOB ALDOC

3.12e-0651563CID000029587
DrugAC1NX490

ALDOA ALDOB ALDOC

3.12e-0651563CID005743230
Drugphosphoglycollamide

ALDOA ALDOB ALDOC

3.12e-0651563CID000191768
DrugD-erythrulose 1-phosphate

ALDOA ALDOB ALDOC

3.12e-0651563CID000152153
Drughydroxypyruvaldehyde phosphate

ALDOA ALDOB ALDOC

3.12e-0651563CID000193787
Drugmycestericin D

ALDOA ALDOB ALDOC

6.22e-0661563CID006439504
DrugC02783

ALDOA ALDOB ALDOC

6.22e-0661563CID000439805
Drug2,2-dimethyl-1,3-dioxan-5-one

ALDOA ALDOB ALDOC

6.22e-0661563CID002733141
Drug2-(N-decyl)aminonaphthalene-6-sulfonic acid

ALDOA ALDOB ALDOC

6.22e-0661563CID000189836
Drugparapyruvate

ALDOA ALDOB ALDOC

6.22e-0661563CID000440249
Drugacetyldithio-CoA

ALDOA ALDOB ALDOC

6.22e-0661563CID003082679
Drug0 Gz

ALDOA ALDOB ALDOC

6.22e-0661563CID000000372
Drugglucose-6-P

SLC2A7 CAPN3 INSR GBA2 EIF2D IGF1R GRK2 VPS35 UHMK1 ALDOA ALDOB ALDOC

8.78e-0636615612CID000000208
DrugVitexin [3681-93-4]; Up 200; 9.2uM; MCF7; HT_HG-U133A

RASA3 INSR HESX1 ZNF710 L3MBTL1 ADAMTS7 SLC9A7 IL1RAP GAB1

9.41e-0619815694413_UP
Drugacenaphthenone

ALDOA ALDOB ALDOC

1.08e-0571563CID000075229
DrugDAPpNP

ALDOA ALDOB ALDOC

1.08e-0571563CID005492375
Drug5-deoxy-D-xylulose-1-phosphate

ALDOA ALDOB ALDOC

1.08e-0571563CID000192931
DrugZ-Glu-Tyr

ALDOA ALDOB ALDOC

1.08e-0571563CID000096820
DrugC0447

ALDOA ALDOB ALDOC

1.08e-0571563CID000128786
Drug3-hydroxy-4-oxobutyl-1-phosphonate

ALDOA ALDOB ALDOC

1.72e-0581563CID003016813
DrugL-rhamnulose-1-phosphate

ALDOA ALDOB ALDOC

1.72e-0581563CID000439413
Drugamorphin

ALDOA ALDOB ALDOC

1.72e-0581563CID000122792
Drugdeoxyribose

ITGA5 ALDOA ALDOB ALDOC

2.40e-05251564CID000010786
Drug2-oxopentenoate

ALDOA ALDOB ALDOC

2.57e-0591563CID000000976
Drug2,4,4'-trichlorobiphenyl

KDM5B PRTG EP400 INPP4A CECR2 E2F7 DAPK1 BEND4 CSMD3 PNPLA5 BRWD3 NUP205 KIF20A MLIP NUP155 ADAMTS7 UHMK1 SLC9A7 TANC1 CHURC1 POLQ GMPPA UNC80 CD276

3.35e-05141115624ctd:C081766
Drugtartronate semialdehyde

ALDOA ALDOB ALDOC

3.66e-05101563CID000001122
DrugSM-8

ALDOA ALDOB ALDOC

3.66e-05101563CID000486037
DrugUrsolic acid [77-52-1]; Up 200; 8.8uM; MCF7; HT_HG-U133A

KLHL24 INPP4A DAPK1 BCAN KLHL20 NID1 KLK13 DOP1B

3.79e-0518215682230_UP
DrugInsulin Glargine

INSR IGF1R

4.66e-0521562ctd:D000069036
DrugInsulin Lispro

INSR IGF1R

4.66e-0521562DB00046
DrugInsulin Glargine

INSR IGF1R

4.66e-0521562DB00047
DrugIchiba acid

ALDOA ALDOC

4.66e-0521562CID000440403
Drug3-HM

ALDOA ALDOC

4.66e-0521562CID000439464
Drugbromohydroxyacetone phosphate

ALDOA ALDOC

4.66e-0521562CID000152675
Druganthracene diol

ALDOA ALDOC

4.66e-0521562CID000155464
Drug2,4,5,2',5'-pentachlorobiphenyl

KDM5B PRTG EP400 INPP4A CECR2 E2F7 DAPK1 BEND4 CSMD3 PNPLA5 BRWD3 NUP205 KIF20A MLIP NUP155 ADAMTS7 UHMK1 SLC9A7 TANC1 CHURC1 POLQ GMPPA UNC80 CD276

4.69e-05144115624ctd:C009828
Drugketose

ITGA2 ALDOA ALDOB ALDOC

5.78e-05311564CID000439494
DrugTenoxicam [59804-37-4]; Up 200; 11.8uM; MCF7; HT_HG-U133A

PAPPA2 INPP4A DAPK1 ADAMTSL3 CD1E MOXD1 EFR3B LTK

5.95e-0519415684182_UP
DrugDNA-PK Inhibitor III; Down 200; 1uM; MCF7; HT_HG-U133A

TANC2 PAPPA2 DSC2 INPP4A MUC5B ITGA5 KLK13 PADI1

6.39e-0519615687513_DN
DrugAC1Q5BXE

UHMK1 ALDOA ALDOB ALDOC

6.57e-05321564CID000000037
DrugLY294002; Up 200; 10uM; ssMCF7; HG-U133A

TANC2 KLHL24 DYSF PMEPA1 IGF1R RNH1 KLK13 HERC5

6.63e-051971568401_UP
DrugAlthiazide [5588-16-9]; Up 200; 10.4uM; MCF7; HT_HG-U133A

PAPPA2 RASA3 GRK2 L3MBTL1 COL21A1 ALDOB CFAP69 CPNE7

6.63e-0519715686829_UP
Drug1trd

ALDOA ALDOB ALDOC

6.63e-05121563CID000004797
Drugdihydropteridine

ALDOA ALDOB ALDOC

6.63e-05121563CID000000167
Drugmethyl triflate

INSR ITGA2 RNH1

6.63e-05121563CID000009526
DrugLincomycin hydrochloride [859-18-7]; Down 200; 9uM; HL60; HT_HG-U133A

IPO5 PAPPA2 CAPN3 INSR ZNF710 FEM1B CAPN5 CPNE7

6.87e-0519815682380_DN
DrugGliquidone [33342-05-1]; Down 200; 7.6uM; MCF7; HT_HG-U133A

PAPPA2 INPP4A BCAN OCRL ITGA2 KLHL20 FAAH ANGEL2

6.87e-0519815686505_DN
Drug3,4,3',4'-tetrachlorobiphenyl

IPO5 KLHL24 DSC2 INSR MRPL19 NHLRC2 PEX11A GBA2 NDFIP1 FCGBP SYDE2 IL1RAP

7.07e-0545315612ctd:C028451
Drug6-bromocyclohex-4-ene-1,2,3-triol

CAPN3 ITGA2 ITGA5 GBA2

7.43e-05331564CID000122062
Drugfuculose

ALDOA ALDOB ALDOC

8.58e-05131563CID000000841
Drugbeta-isopropyl-tropolone

ALDOA ALDOB ALDOC

1.09e-04141563CID000080297
Drug2-keto-4-hydroxyglutarate

ALDOA ALDOB ALDOC

1.09e-04141563CID000000599
DrugValimon

CAPN3 GBA2 UHMK1

1.35e-04151563CID000037716
DrugMecasermin

INSR IGF1R

1.39e-0431562DB01277
Drug3,3,3-trifluoropropanoic acid

ALDOA ALDOC

1.39e-0431562CID002777972
Drug4-fluorothreonine

ALDOA ALDOC

1.39e-0431562CID000128057
Drug(4S,7R,8R,9R,13Z,16S)-4,8-dihydroxy-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methylthiazol-4-yl)vinyl]-1-oxacyclohexadec-13-ene-2,6-dione

ALDOA ALDOC

1.39e-0431562CID009869661
DrugAC1L19ID

ALDOA ALDOC

1.39e-0431562CID000000560
DrugCilengitide

ITGA5 ITGB5

1.39e-0431562ctd:C422910
DrugC11 -427

ALDOA ALDOC

1.39e-0431562CID000443195
Drugglycidaldehyde

ALDOA ALDOB ALDOC

1.65e-04161563CID000013002
Drugtrimethylaminobutyraldehyde

ALDOA ALDOB ALDOC

2.00e-04171563CID000000133
Drug3HPP

ALDOA ALDOB ALDOC

2.00e-04171563CID000000091
DrugZnATP

ALDOA ALDOB ALDOC

2.00e-04171563CID006455240
DrugN-bromoacetylethanolamine phosphate

ALDOA ALDOB ALDOC

2.00e-04171563CID000188343
DrugIodogen

HESX1 ALDOA ALDOB ALDOC

2.33e-04441564CID000040065
Drug2-deoxyribose 5-phosphate

ALDOA ALDOB ALDOC

2.39e-04181563CID000150629
Drug1H-imidazole hydrochloride

ALDOA ALDOB ALDOC

2.39e-04181563CID000518985
Drugribulose-1,5-bisphosphate

NDUFAB1 SLC7A3 ALDOA ALDOB ALDOC

2.53e-04821565CID000001192
DrugD -Adonose

UGDH ALDOA ALDOB ALDOC

2.54e-04451564CID000079021
DrugAC1L1GKK

INSR IGF1R

2.77e-0441562CID000003725
Drug9-fluorenone-1-carboxylic acid

ALDOA ALDOC

2.77e-0441562CID000074083
Drugtris(dimethylamino)phosphonium

ITGA2 NDUFAB1

2.77e-0441562CID000015355
DrugAC1L9A8P

ALDOA ALDOC

2.77e-0441562CID000440943
Drug9-chloromethylanthracene

INSR DTX2

2.77e-0441562CID000032385
Drugphenanthrene trans-3,4-dihydrodiol

ALDOA ALDOC

2.77e-0441562CID000119398
DrugDHMP

ALDOA ALDOC

2.77e-0441562CID000098784
DrugAC1L2YVP

ALDOA ALDOB ALDOC

2.82e-04191563CID000080135
Drugmalonate semialdehyde

ALDOA ALDOB ALDOC

2.82e-04191563CID000000868
Diseaseamino acid measurement

TANC2 IPO5 MED10 SLC2A7 E2F7 NXPE2 ITGA2 ACKR4 PMEPA1 RYR3 CNTN5 MCM9 SLIT3 PRKDC

1.27e-0567815314EFO_0005134
DiseaseDSGEGDFXAEGGGVR measurement

PEX11A IGF1R

7.99e-0531532EFO_0021136
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

INSR FEM1B IGF1R ADAMTS20 ALDOB

2.23e-041051535DOID:9352 (implicated_via_orthology)
Diseasegestational diabetes (biomarker_via_orthology)

INSR IGF1R

2.64e-0451532DOID:11714 (biomarker_via_orthology)
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Positive

DAPK1 DYSF BEND2 ITGB5 IGF1R

6.18e-041311535C4704862
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Negative

DAPK1 DYSF BEND2 ITGB5 IGF1R

6.18e-041311535C4552091
DiseaseJuvenile arthritis

DAPK1 DYSF BEND2 ITGB5 IGF1R

6.18e-041311535C3495559
DiseaseJuvenile psoriatic arthritis

DAPK1 DYSF BEND2 ITGB5 IGF1R

6.18e-041311535C3714758
Diseasejoint hypermobility measurement

PRTG EFEMP1 COL21A1

6.65e-04331533EFO_0007905
Diseasecreatinine measurement

DNAJC13 INPP4A FSD2 BEND4 PMEPA1 BRWD3 IGF1R MLIP ADAMTS7 KLHDC7A ALDOB UNC80 CPNE7 DUSP11

7.01e-0499515314EFO_0004518
DiseaseJuvenile-Onset Still Disease

DAPK1 DYSF BEND2 ITGB5 IGF1R

7.08e-041351535C0087031
Diseaseglycylvaline measurement

NDFIP1 DNAH11

7.33e-0481532EFO_0021129
DiseaseLung diseases

INSR IGF1R PRKDC DNAH11

7.36e-04781534C0024115
Diseasealcohol dependence (implicated_via_orthology)

INSR IGF1R

9.39e-0491532DOID:0050741 (implicated_via_orthology)
Diseasecarpal tunnel syndrome

PMEPA1 ITGB5 EFEMP1 FDPS

1.21e-03891534EFO_0004143
Diseasehigh grade glioma (is_marker_for)

KDM5B BCAN EFEMP1

1.35e-03421533DOID:3070 (is_marker_for)
Diseasesleep disorder (implicated_via_orthology)

INSR IGF1R

1.42e-03111532DOID:535 (implicated_via_orthology)
Diseasepro‐interleukin‐16 measurement

FSD2 ADAMTSL3

1.42e-03111532EFO_0010629
Diseasehigh grade glioma (implicated_via_orthology)

INSR BCAN IGF1R

1.55e-03441533DOID:3070 (implicated_via_orthology)
Diseasecongenital diaphragmatic hernia (implicated_via_orthology)

KIF7 SLIT3

1.70e-03121532DOID:3827 (implicated_via_orthology)
Diseaseleft atrial volume measurement

EIF2D EFEMP1

1.70e-03121532EFO_0600035
Diseasedistal myopathy (implicated_via_orthology)

DYSF MYH15

1.70e-03121532DOID:11720 (implicated_via_orthology)
DiseaseAutosomal recessive limb-girdle muscular dystrophy

CAPN3 DYSF

2.33e-03141532cv:C2931907
Diseasediabetic neuropathy (implicated_via_orthology)

INSR IGF1R

2.33e-03141532DOID:9743 (implicated_via_orthology)
Diseasemuscular dystrophy (is_implicated_in)

CAPN3 DYSF

3.45e-03171532DOID:9884 (is_implicated_in)
DiseaseAstrocytosis

ITGA2 ITGA5

3.45e-03171532C3887640
Diseasepre-malignant neoplasm (biomarker_via_orthology)

INSR SUV39H1

3.45e-03171532DOID:0060071 (biomarker_via_orthology)
DiseaseGliosis

ITGA2 ITGA5

3.45e-03171532C0017639
Diseasebipolar disorder, sex interaction measurement

SLIT3 SIPA1L2

3.87e-03181532EFO_0008343, MONDO_0004985
Diseasemigraine disorder, systolic blood pressure

RNF213 ITGB5

3.87e-03181532EFO_0006335, MONDO_0005277
DiseaseIGF-1 measurement

DOCK3 PAPPA2 CAPN3 PMEPA1 HESX1 KIF7 SLIT3 DOP1B

4.06e-034881538EFO_0004627
DiseaseCongenital hernia of foramen of Morgagni

INSR IGF1R

4.31e-03191532C0265699
DiseaseCongenital hernia of foramen of Bochdalek

INSR IGF1R

4.31e-03191532C0265700
Diseaseprostate adenocarcinoma (is_implicated_in)

INSR IGF1R

4.77e-03201532DOID:2526 (is_implicated_in)
Diseasecerebellum white matter volume change measurement, age at assessment

TRHDE ADAMTS7

4.77e-03201532EFO_0008007, EFO_0021498

Protein segments in the cluster

PeptideGeneStartEntry
NRIPLNVRDIVYCTG

TRHDE

846

Q9UKU6
GQYIYRLEPNVEELC

CHTF18

811

Q8WVB6
DQIYLVNERRCSQAP

EP400

1751

Q96L91
INNLYPGCENVSVRS

DAPK1

746

P53355
DPYSVAAILQQRCQA

EIF2D

516

P41214
YESRLGCLENSIPQL

CYP27C1

236

Q4G0S4
PGYELQGEERITCIQ

CSMD3

1556

Q7Z407
LARYASICQQNGIVP

ALDOC

171

P09972
LARYASICQQNGLVP

ALDOB

171

P05062
LARYASICQQNGIVP

ALDOA

171

P04075
LSRIPDENCQINRYG

GPNMB

361

Q14956
QVPGRVTQLCRQYSD

NDUFAB1

56

O14561
NAEQLCRYQGPVLLI

ABHD16A

411

O95870
GYCPRCQELEQEVIS

BEND4

321

Q6ZU67
YLPLEVCNIVAGQRC

AGO1

336

Q9UL18
ENLSCIYDQLQAPVV

DNAH11

286

Q96DT5
CKDEQLIPQLGYVAN

BRWD3

611

Q6RI45
GTYSCLVRNPVLQQD

CD276

216

Q5ZPR3
IDDRLPTVNNQLIYC

CAPN5

136

O15484
QDENGINRPVCSYVK

CEP76

311

Q8TAP6
LGISQNCVYEVQQVP

ANGEL2

401

Q5VTE6
NGLSQEGPIYRCQEE

CECR2

1401

Q9BXF3
QPRLGEKVYLCNQDE

DSC2

831

Q02487
RLVICQFPNGQILED

ADAMTS20

1381

P59510
VQRQNVYCLERQAGP

ADAMTS7

841

Q9UKP4
FQPYIEEICQNLRGD

GRK2

146

P25098
IPNVQLDDAGIYECR

CNTN5

356

O94779
LYFPAQLRQQTEELC

MLIP

251

Q5VWP3
QRGYQVCPVLADIEC

MUC5B

1366

Q9HC84
ERLKQGCEIIQSTPY

DENND4A

111

Q7Z401
KQVLGPQCLSYEVER

PADI1

226

Q9ULC6
PERALYIQANNCVEA

RASA3

651

Q14644
CEELRYGAQAQVPTL

RGS11

336

O94810
SGCQSIIYIPQDVVR

INPP4A

396

Q96PE3
VAVRESPQLAELCYQ

NUP205

1051

Q92621
IQLRSDEECRQVYPG

KLK13

181

Q9UKR3
ALDPRQAGQYVLCDV

RADIL

101

Q96JH8
PQLVFYTVNDNARCI

ACKR4

171

Q9NPB9
ELRPNDSGIYRCEVQ

BCAN

126

Q96GW7
FQNRVPELSYLGIIC

SLC2A7

371

Q6PXP3
QCYLPDNAQGRKVLE

DTX2

536

Q86UW9
IEYGIQRITCPNVDG

IL1RAP

151

Q9NPH3
EGCQRLYPVLQQSLV

EXOSC6

246

Q5RKV6
IQEDPQDYLLLINCQ

GAB1

176

Q13480
LVVQCLQRATPEQYQ

FDPS

336

P14324
EVQTQYLPQVLGCLV

DOP1B

496

Q9Y3R5
EILPCNRYSSEQNGA

KMT5B

196

Q4FZB7
YIEQLNNCRIGLQPA

KIAA1109

1046

Q2LD37
LGALVCRVQLVTYQP

FRMD8P1

171

Q9BZ68
LQENYPICDLSENGR

BEND2

731

Q8NDZ0
AYGNRTECRNPQELE

FEM1B

301

Q9UK73
EICGPGIDIRNDYQQ

IGF1R

31

P08069
ENLFGAEYQLQICVP

ITGAE

996

P38570
RLQYCTQDPDVLNSL

LTK

776

P29376
NDGCPQLFQERSVIV

L3MBTL1

186

Q9Y468
VAVVDQRPINYCETG

NID1

751

P14543
VAQVNEENLPVYNRC

EFR3B

576

Q9Y2G0
YQVSVGQCLRAVDPL

GALNT11

571

Q8NCW6
EVLENVFRVNCYPGI

HESX1

121

Q9UBX0
GQEAVYQACVQPLLE

KIF7

66

Q2M1P5
IIDQLGCLVITGNQY

PI4KA

656

P42356
YLREDPVCGAQLQNQ

KIF26A

551

Q9ULI4
YEGIARNLSCREPNQ

ENPP1

471

P22413
VPVYRTNQCAGEFVI

KDM5B

566

Q9UGL1
TGYRIELQACNQDTP

INSR

816

P06213
IRTYQVCNVLEPNQD

EPHA10

71

Q5JZY3
IDQGRNPQLYTKECL

MED10

71

Q9BTT4
LQYVCDNSPEVRQAA

IPO5

911

O00410
YRGSVNITDDCQKPQ

PLA2G4F

586

Q68DD2
CDVGYPALKREQQVT

ITGA2

876

P17301
QSVYQNLCREAEGKP

ITGB5

506

P18084
DTQQGCIAPVELRYV

NHLRC2

711

Q8NBF2
LIRYVENPSQVLNCE

NUP155

1331

O75694
NLRCLQGRVNPVEYS

SMPD4

106

Q9NXE4
YQGPCTLQLRDPEQQ

PMEPA1

161

Q969W9
VPQEDRLYLVGNVCI

PASD1

161

Q8IV76
QIINYTIRCNPVGLQ

PRTG

751

Q2VWP7
QNELRPCLVAELVGY

HERC5

281

Q9UII4
IYIQENNLPGVLLCT

PCDHAC2

476

Q9Y5I4
AQRNISLQDICYAPL

NPC1L1

461

Q9UHC9
ELSCPQALEGQQLLY

ITGA5

846

P08648
VEPACGSRYQQLQNE

NDFIP1

11

Q9BT67
RYQVVNICDDEGLNP

PAPPA2

526

Q9BXP8
RTQSLNYGCIVENPQ

GMPPA

146

Q96IJ6
LADNPRYCIGLNETQ

ECI1

166

P42126
QLEYPFEIQILAGCR

CD1E

116

P15812
QDGVSCLNIVERYDP

KLHL20

421

Q9Y2M5
VDQLIQNSPECYQLL

KLHL24

271

Q6TFL4
LPELKRETYGQIQVC

E2F7

386

Q96AV8
PDDAILQCDAQYLQI

DOCK3

1406

Q8IZD9
CLERQNYIEDLQNGP

DUSP11

236

O75319
LGLAFQTPEAYCQQR

GBA2

856

Q9HCG7
IPDGVLANQVYQCIV

CDIN1

131

Q9Y2V0
YEPEQTVLIDNCRQQ

FCGBP

3996

Q9Y6R7
EVPLREINQKYGCNR

POLQ

731

O75417
IQGVVEAYQNCLPRV

CPNE7

466

Q9UBL6
LRIYCDPEQNNRETA

COL21A1

406

Q96P44
EVILATPYGRCANVN

DENND4C

116

Q5VZ89
IINYPQLENELFCNI

DNAJC13

1241

O75165
PQVRLDLGNCYEVLT

KLHDC7A

426

Q5VTJ3
KEDIGNYSCLVRNPV

HEPACAM2

211

A8MVW5
PGDEQVNCFNINYLR

ECM1

491

Q16610
CETQLSQAPRQGLLY

FAAH

121

O00519
VACRYQNLTEVPDAI

CHADL

46

Q6NUI6
VVIDDCLPTYNNQLV

CAPN3

176

P20807
QCYQNGLPLRDLAQI

CFAP69

76

A5D8W1
AAQGPQECLVRIYIV

DYSF

1571

O75923
VSICVLILRYQPDQE

SLC7A3

421

Q8WY07
TRNETGPYQCEIQDR

PSG3

301

Q16557
SQGDREPVYRDCVLQ

PGAP3

21

Q96FM1
EEPALSQYQRLLCIN

NUP88

91

Q99567
PENPGEQYQRQCELI

MCM9

621

Q9NXL9
PQGYQVVRSRTCQDI

EFEMP1

321

Q12805
VGLCENQYPDINVIT

SYDE2

876

Q5VT97
VGPTCDEYAQKVRQQ

TARS1

626

P26639
IFPQIGQIQYCSLEE

SFXN4

306

Q6P4A7
SVEDLGQVRYLQLCP

LRRC56

171

Q8IYG6
TCYPERVVGVLNAIN

NKPD1

241

Q17RQ9
ILNPQDTYCRGDQLD

NXPE2

116

Q96DL1
LDPYLVLQQLRCNGV

MYH15

696

Q9Y2K3
PSLEVVADNCRQGYL

PNPLA5

231

Q7Z6Z6
TRNETGPYQCEIRDQ

PSG8

301

Q9UQ74
CESVVQLQPGRSYII

FSD2

526

A1L4K1
EYVIPELSIQCLRQA

SIPA1L2

571

Q9P2F8
VNYRTEVLNNAPILC

TANC1

926

Q9C0D5
INYRTEVLNNAPILC

TANC2

876

Q9HCD6
NLCDILNPLDQLGIY

PEX11A

201

O75192
EPCALTLAQRNGQYE

OCRL

26

Q01968
DCPNRVVQKGIRYDL

SUV39H1

231

O43463
CQLQNRDVLNPVYVE

EARS2

386

Q5JPH6
YVLPDGKEIQLCQER

ACTL7A

301

Q9Y615
VEKEYPNRGNTCLEN

CHURC1

6

Q8WUH1
EICFELYNPRVQEIQ

MRPL19

161

P49406
KNNGTCTQDPVELYR

SLIT3

926

O75094
VDNTQVPSYCLNARG

TBC1D24

96

Q9ULP9
ERDLTPLILSNCQYQ

RNF213

4926

Q63HN8
PLILSNCQYQVEEGR

RNF213

4931

Q63HN8
PEGQRAVQALCAVYE

UGDH

186

O60701
ARCLQSQGVSLYIPQ

VSTM5

26

A8MXK1
SLPDCLQVVREVQYD

UBAP1

41

Q9NZ09
SPENLGLYCDIRQLV

UNC80

921

Q8N2C7
QTILPGDNLITECRY

MOXD1

431

Q6UVY6
RQTLRLCEDQNGNPY

KIF20A

326

O95235
NIYVERQRPALGECL

RYR3

3041

Q15413
NYLLQCTRNILPDEG

VPS35

151

Q96QK1
AIQICEYLRLPEVQG

VPS16

466

Q9H269
VYQLACNGRALEEPA

ZNF710

66

Q8N1W2
SVRQPGCLLEQLVLY

RNH1

421

P13489
YGNTVCVQEILQRCP

SLF1

851

Q9BQI6
LCAVNLYGPDAQVDR

PRKDC

1431

P78527
IDRQACEQLYNPIGI

PRSS48

176

Q7RTY5
INTQCGYDARQKPEV

TSPAN5

196

P62079
LARCLTSPQVYDNQE

SLC9A7

631

Q96T83
VCNLGAEQTLPQEYQ

SMC5

826

Q8IY18
GYRAPEAELQNCLAQ

UHMK1

196

Q8TAS1
LQLYVCSVTPQLQEE

WWC3

686

Q9ULE0
QLGYNLREVCPVQEI

ZSCAN23

171

Q3MJ62
QNPTRKEQGIYECSV

ADAMTSL3

1251

P82987