Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentdesmosome

DSC2 DSC3

2.05e-0428162GO:0030057
GeneOntologyCellularComponentcornified envelope

DSC2 DSC3

1.25e-0369162GO:0001533
GeneOntologyCellularComponentcalcium channel complex

TRPV5 TRPV6

1.40e-0373162GO:0034704
DomainTRPV5/TRPV6

TRPV5 TRPV6

5.22e-072142IPR008344
DomainCadherin_pro

DSC2 DSC3

1.09e-057142PF08758
DomainDesmosomal_cadherin

DSC2 DSC3

1.09e-057142IPR009122
DomainCadherin_pro_dom

DSC2 DSC3

1.46e-058142IPR014868
DomainCadherin_pro

DSC2 DSC3

1.46e-058142SM01055
DomainTRP_channel

TRPV5 TRPV6

2.86e-0511142IPR004729
DomainCadherin_C

DSC2 DSC3

1.55e-0425142PF01049
DomainCadherin_cytoplasmic-dom

DSC2 DSC3

1.55e-0425142IPR000233
DomainCatenin_binding_dom

DSC2 DSC3

2.09e-0429142IPR027397
Domain-

DSC2 DSC3

2.09e-04291424.10.900.10
DomainCadherin_CS

DSC2 DSC3

2.93e-03109142IPR020894
DomainCadherin

DSC2 DSC3

3.15e-03113142PF00028
DomainCADHERIN_1

DSC2 DSC3

3.15e-03113142PS00232
DomainIon_trans_dom

TRPV5 TRPV6

3.20e-03114142IPR005821
Domain-

DSC2 DSC3

3.20e-031141422.60.40.60
DomainIon_trans

TRPV5 TRPV6

3.20e-03114142PF00520
DomainCADHERIN_2

DSC2 DSC3

3.20e-03114142PS50268
DomainCA

DSC2 DSC3

3.26e-03115142SM00112
DomainCadherin-like

DSC2 DSC3

3.31e-03116142IPR015919
DomainCadherin

DSC2 DSC3

3.43e-03118142IPR002126
DomainEF_Hand_1_Ca_BS

EFCAB6 PLCD3

7.38e-03175142IPR018247
DomainEF_HAND_1

EFCAB6 PLCD3

9.91e-03204142PS00018
DomainAnk_2

TRPV5 TRPV6

1.10e-02215142PF12796
DomainAnk

TRPV5 TRPV6

1.23e-02228142PF00023
DomainEF_HAND_2

EFCAB6 PLCD3

1.26e-02231142PS50222
Domain-

TRPV5 TRPV6

1.44e-022481421.25.40.20
DomainANK

TRPV5 TRPV6

1.47e-02251142SM00248
DomainANK_REPEAT

TRPV5 TRPV6

1.49e-02253142PS50088
DomainAnkyrin_rpt-contain_dom

TRPV5 TRPV6

1.51e-02254142IPR020683
DomainANK_REP_REGION

TRPV5 TRPV6

1.51e-02254142PS50297
Domain-

EFCAB6 PLCD3

1.58e-022611421.10.238.10
DomainAnkyrin_rpt

TRPV5 TRPV6

1.60e-02262142IPR002110
DomainEF-hand-dom_pair

EFCAB6 PLCD3

1.90e-02287142IPR011992
PathwayREACTOME_TRP_CHANNELS

TRPV5 TRPV6

2.48e-0428122MM14943
PathwayREACTOME_TRP_CHANNELS

TRPV5 TRPV6

2.48e-0428122M27241
PathwayPID_PTP1B_PATHWAY

TRPV6 LCK

8.60e-0452122M50
PathwayPID_CD8_TCR_PATHWAY

TRPV6 LCK

8.94e-0453122M88
Pubmed

Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3.

TRPV5 TRPV6

2.25e-07217212077127
Pubmed

Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4.

TRPV5 TRPV6

2.25e-07217216565876
Pubmed

Expression of transient receptor potential vanilloid channels TRPV5 and TRPV6 in retinal pigment epithelium.

TRPV5 TRPV6

2.25e-07217220405023
Pubmed

Alteration of calcium homeostasis in primary preeclamptic syncytiotrophoblasts: effect on calcium exchange in placenta.

TRPV5 TRPV6

2.25e-07217220178461
Pubmed

The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties.

TRPV5 TRPV6

2.25e-07217222354706
Pubmed

Diverse calcium channel types are present in the human placental syncytiotrophoblast basal membrane.

TRPV5 TRPV6

2.25e-07217216564089
Pubmed

Single-channel activities of the human epithelial Ca2+ transport proteins CaT1 and CaT2.

TRPV5 TRPV6

2.25e-07217211719848
Pubmed

A single amino acid mutation results in a rapid inactivation of epithelial calcium channels.

TRPV5 TRPV6

2.25e-07217211846401
Pubmed

Concerted action of associated proteins in the regulation of TRPV5 and TRPV6.

TRPV5 TRPV6

2.25e-07217217233615
Pubmed

First evidence of TRPV5 and TRPV6 channels in human parathyroid glands: possible involvement in neoplastic transformation.

TRPV5 TRPV6

2.25e-07217225164318
Pubmed

Endogenous expression of TRPV5 and TRPV6 calcium channels in human leukemia K562 cells.

TRPV5 TRPV6

2.25e-07217219295174
Pubmed

Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity.

TRPV5 TRPV6

2.25e-07217223968883
Pubmed

Expression of calcium channels along the differentiation of cultured trophoblast cells from human term placenta.

TRPV5 TRPV6

2.25e-07217212390878
Pubmed

[The functional characteristics oF TRPV5 and TRPV6 channels in normal and transformed human blood lymphocytes].

TRPV5 TRPV6

2.25e-07217224592736
Pubmed

Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6.

TRPV5 TRPV6

2.25e-07217212574114
Pubmed

Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6.

TRPV5 TRPV6

2.25e-07217216705151
Pubmed

Expression and prognostic roles of TRPV5 and TRPV6 in non-small cell lung cancer after curative resection.

TRPV5 TRPV6

2.25e-07217224761864
Pubmed

Structural conservation of the genes encoding CaT1, CaT2, and related cation channels.

TRPV5 TRPV6

2.25e-07217211549322
Pubmed

[TRPV5 and TRPV6 calcium channels in human T cells].

TRPV5 TRPV6

2.25e-07217219140341
Pubmed

TRPV5 and TRPV6 are expressed in placenta and bone tissues during pregnancy in mice.

TRPV5 TRPV6

2.25e-07217230916584
Pubmed

Regulation of the mouse epithelial Ca2(+) channel TRPV6 by the Ca(2+)-sensor calmodulin.

TRPV5 TRPV6

2.25e-07217215123711
Pubmed

Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels.

TRPV5 TRPV6

6.74e-07317217200157
Pubmed

Assignment of the human genes for desmocollin 3 (DSC3) and desmocollin 4 (DSC4) to chromosome 18q12.

DSC2 DSC3

6.74e-0731727774948
Pubmed

cDNA cloning and expression of a novel human desmocollin.

DSC2 DSC3

6.74e-0731727929347
Pubmed

Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear.

TRPV5 TRPV6

6.74e-07317219922080
Pubmed

Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport.

TRPV5 TRPV6

6.74e-07317216763551
Pubmed

Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity.

TRPV5 TRPV6

6.74e-07317216380433
Pubmed

A molecular determinant of phosphoinositide affinity in mammalian TRPV channels.

TRPV5 TRPV6

6.74e-07317227291418
Pubmed

Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane.

TRPV5 TRPV6

6.74e-07317216354700
Pubmed

The influence of desmocollin 1-3 expression on prognosis after curative resection of colorectal liver metastases.

DSC2 DSC3

6.74e-07317223975055
Pubmed

Structure and function of desmosomal proteins and their role in development and disease.

DSC2 DSC3

6.74e-07317214523549
Pubmed

Compositionally different desmosomes in the various compartments of the human hair follicle.

DSC2 DSC3

6.74e-0731729810708
Pubmed

Desmocollin switching in colorectal cancer.

DSC2 DSC3

6.74e-07317217088906
Pubmed

Changing pattern of desmocollin 3 expression accompanies epidermal organisation during skin development.

DSC2 DSC3

6.74e-0731729389456
Pubmed

Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex.

TRPV5 TRPV6

1.35e-06417212660155
Pubmed

Plakoglobin as a regulator of desmocollin gene expression.

DSC2 DSC3

1.35e-06417223652796
Pubmed

Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma.

DSC2 DSC3

2.25e-06517222438068
Pubmed

Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP).

DSC2 DSC3

2.25e-0651721889810
Pubmed

Nomenclature of the desmosomal cadherins.

DSC2 DSC3

2.25e-0651728486729
Pubmed

Role and regulation of TRP channels in neutrophil granulocytes.

TRPV5 TRPV6

2.25e-06517212765698
Pubmed

Calcium transport genes are differently regulated in maternal and fetal placenta in the knockout mice of calbindin-D(9k) and -D(28k).

TRPV5 TRPV6

2.25e-06517222407925
Pubmed

Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse.

DSC2 DSC3

3.37e-0661729404003
Pubmed

Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18.

DSC2 DSC3

3.37e-0661727959727
Pubmed

Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects.

TRPV5 TRPV6

6.29e-06817233859252
Pubmed

Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype.

DSC2 DSC3

1.01e-051017212724416
Pubmed

Defining desmosomal plakophilin-3 interactions.

DSC2 DSC3

1.48e-051217212707304
Pubmed

Assessment of splice variant-specific functions of desmocollin 1 in the skin.

DSC2 DSC3

1.75e-051317214673151
Pubmed

Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos.

TRPV5 TRPV6

1.75e-051317222266179
Pubmed

Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice.

DSC2 DSC3

2.35e-05151729847250
Pubmed

Desmocollin 3 is required for pre-implantation development of the mouse embryo.

DSC2 DSC3

2.69e-051617216418220
Pubmed

IRF6 and AP2A Interaction Regulates Epidermal Development.

DSC2 DSC3

2.69e-051617229913133
Pubmed

RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis.

DSC2 DSC3

2.69e-051617230689641
Pubmed

Mapping the expression of transient receptor potential channels across murine placental development.

TRPV5 TRPV6

6.17e-052417233884443
Pubmed

International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.

TRPV5 TRPV6

6.70e-052517216382100
Pubmed

An introduction to TRP channels.

TRPV5 TRPV6

7.84e-052717216460286
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

TRPV5 TRPV6

1.18e-043317219834762
Pubmed

A genome-wide association study (GWAS) for bronchopulmonary dysplasia.

DSC2 DSC3

1.25e-043417223897914
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

TRPV5 TRPV6

1.56e-043817230786075
Pubmed

Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.

TRPV5 TRPV6

2.10e-044417219322198
Pubmed

Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.

DSC2 DSC3

4.88e-046717221875946
InteractionGPR156 interactions

PLCD3 PHTF1 GTF3C1

1.85e-0571153int:GPR156
InteractionCALB1 interactions

TRPV5 TRPV6

7.86e-0518152int:CALB1
InteractionUBXN6 interactions

PLCD3 VPS16 LCK GTF3C1

7.88e-05325154int:UBXN6
Cytoband18q12.1

DSC2 DSC3

4.17e-052617218q12.1
CytobandEnsembl 112 genes in cytogenetic band chr18q12

DSC2 DSC3

6.76e-04104172chr18q12
CytobandEnsembl 112 genes in cytogenetic band chr7q34

TRPV5 TRPV6

2.11e-03185172chr7q34
GeneFamilyDesmosomal cadherins

DSC2 DSC3

4.62e-067921188
GeneFamilyTransient receptor potential cation channels

TRPV5 TRPV6

8.27e-052892249
GeneFamilyAnkyrin repeat domain containing

TRPV5 TRPV6

6.04e-0324292403
CoexpressionGSE11057_NAIVE_CD4_VS_PBMC_CD4_TCELL_UP

FNBP4 ECHDC2 TRAF3IP3 LCK

6.96e-06198174M3108
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_LATE_MESOTHELIAL_CELL

DSC2 DSC3 PLCD3 ECHDC2 TCAIM

6.52e-05704175M45672
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Epcam____kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSC2 PLCD3 TRPV5 TRPV6

7.48e-071931740208fcd8ea4662f40fc2c072ac220d97823eec12
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6|Hippocampus / BrainAtlas - Mouse McCarroll V32

DSC3 TRPV6 LCK

1.02e-051131736f270b7e59c18243e876311df721e948ce21e850
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|343B / Donor, Lineage, Cell class and subclass (all cells)

TRAF3IP3 LCK GTF3C1

1.82e-05137173885e4cfc237eca1fa2eb1f2fd8d84f151e21ecfa
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EFCAB6 TRAF3IP3 LCK

2.29e-051481737cb4865a1e9522e24f9c14799568b67172bd99dc
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRAF3IP3 PHTF1 LCK

3.00e-051621735731f9514434296132df4bc86f78ce87b07cdeca
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRAF3IP3 PHTF1 LCK

3.00e-051621730321fc954ae4ad67ca438cbbc84632562d222188
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-regulatory_T_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TRPV6 TRAF3IP3 LCK

3.35e-051681732d2eab3190374f79f373e31c8b062ff4e1766396
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TRPV6 TRAF3IP3 LCK

3.35e-05168173df58156721457b34af1e81c0eb8a7243cbbfb303
ToppCellInt-URO-Lymphocyte-T_NK-CD4_TEM|Int-URO / Disease, Lineage and Cell Type

ECHDC2 TRAF3IP3 LCK

3.41e-051691735b2fb89cbc9b92d609994d6e5aa35a67c3cc8f22
ToppCell10x3'2.3-week_17-19-Lymphocytic_T-T_NK-Treg|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ECHDC2 TRAF3IP3 LCK

3.71e-051741737ca39c9ecd609e5ade30dac1a948a4a4fff1b3b2
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPV5 TRPV6 ZNF503-AS2

3.91e-05177173c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells-CD4_T_cells_L.1.1.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TRAF3IP3 PHTF1 LCK

4.04e-051791736bbb32d7e582a96cb3cfc3eb911b05d518e7d5e9
ToppCell356C-Lymphocytic-NK_cells-NK_cell_B2|356C / Donor, Lineage, Cell class and subclass (all cells)

TRAF3IP3 LCK GTF3C1

4.25e-0518217352baef8173df0a55307c375674a37c2488066738
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-T_cells-Th1|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRPV5 TRAF3IP3 LCK

4.46e-05185173326c8b6ea0e9140616d7b867db1385b980dc3678
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSC2 TRPV5 TRPV6

5.06e-0519317304d47ba7cc1f19f1ffb18d9e68469e75063697cf
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TRAF3IP3 LCK GTF3C1

5.13e-05194173fa72c2f3e6b8bfc2ef126deb219ec6a44809385b
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TRAF3IP3 LCK GTF3C1

5.13e-05194173f0707601883b234ed477c7704ca9a88efaefc3fd
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TRAF3IP3 LCK GTF3C1

5.13e-05194173bc7c4efe2a82057fb95582da983e36f413990902
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-innate_lymphocytic|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TRAF3IP3 LCK GTF3C1

5.13e-051941738bfd7c5be518b81b17913139bcb3ebea01f48dd5
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TRAF3IP3 LCK GTF3C1

5.13e-05194173b43788e458a80ab93f485f4577370aec448ad95e
ToppCell(0)_NK|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

TRAF3IP3 LCK GTF3C1

5.29e-05196173e2578a562d9903a33a7c60db229005680af8141c
ToppCell(0)_NK_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

TRAF3IP3 LCK GTF3C1

5.29e-051961739b080859130cf156bfa833dc71fd39734cb9a32d
ToppCellnormal_Lung-T/NK_cells-NK|normal_Lung / Location, Cell class and cell subclass

TRAF3IP3 LCK GTF3C1

5.37e-051971736045a05a5f1073d683806eb46a3fa98358414625
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DSC3 TRAF3IP3 LCK

5.37e-0519717380ffafa9473f4ee7a3a792d11b5541e1c984c9f0
ToppCellBL-critical-LOC-Lymphoid-CTL|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FNBP4 TRAF3IP3 LCK

5.37e-05197173fb70918867fbd111bb192a797dcafed5f39ea299
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DSC3 TRAF3IP3 LCK

5.37e-05197173f3dfc22ff63e6173451a0917c5aedcde793fd170
ToppCell356C-Lymphocytic-NK_cells|356C / Donor, Lineage, Cell class and subclass (all cells)

TRAF3IP3 LCK GTF3C1

5.37e-05197173ae55ac5c714e55061d605dee030cbe29b43cf9c1
ToppCell390C-Lymphocytic-NK_cells-NK_cell_B|390C / Donor, Lineage, Cell class and subclass (all cells)

TRAF3IP3 LCK GTF3C1

5.45e-051981730dc4a564dcab8ac42f238f98ee1f2090b0dcffe6
ToppCell356C-Lymphocytic-NK_cells-NK_cell_B|356C / Donor, Lineage, Cell class and subclass (all cells)

TRAF3IP3 LCK GTF3C1

5.45e-051981730bf7a339e9ee384f1a198ca7c1c51b9a54a7b99f
ToppCell390C-Lymphocytic-NK_cells|390C / Donor, Lineage, Cell class and subclass (all cells)

TRAF3IP3 LCK GTF3C1

5.45e-05198173872ddb2738c5e0375830bb0e5b2c50383bf58738
ToppCellSepsis-Int-URO-Lymphocyte-T/NK-CD4+_Tem|Int-URO / Disease, condition lineage and cell class

ECHDC2 TRAF3IP3 LCK

5.54e-05199173c55634d4b66ab4e3f9262a83d993ea0c5f01ea61
ToppCell356C-Lymphocytic-NK_cells-NK_cell_A|356C / Donor, Lineage, Cell class and subclass (all cells)

TRAF3IP3 LCK GTF3C1

5.54e-05199173868412bbd8a203f3e9369fb6dc09791c07023496
ToppCelldistal-Hematologic-Natural_Killer-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TRAF3IP3 LCK GTF3C1

5.54e-05199173928b152f3bade90dfdb15e46aaa0c85063db0026
ToppCelldistal-3-Hematologic-Natural_Killer|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TRAF3IP3 LCK GTF3C1

5.62e-05200173ea11ace5d540c02f23242e48e4d0d7d54999af0e
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TRAF3IP3 LCK GTF3C1

5.62e-05200173eda7a1d822e8663510662bc0ca34eaccc88d71ca
ToppCelldistal-1-Hematologic-Natural_Killer|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TRAF3IP3 LCK GTF3C1

5.62e-0520017369756eba4b9b6cd5115aa7b76dfc36bb70097993
ToppCellParenchymal-10x3prime_v2-Immune_Lymphocytic-NK-ILC|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TRAF3IP3 LCK GTF3C1

5.62e-0520017348131c7c9444af84afb23184382d82e850acb445
ToppCellParenchymal-10x3prime_v2-Immune_Lymphocytic-NK-ILC-T_NK-NK|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TRAF3IP3 LCK GTF3C1

5.62e-0520017385bb2f4c97b03258615bc09279c70766c99ec942
ToppCellParenchymal-10x3prime_v2-Immune_Lymphocytic-NK-ILC-T_NK|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TRAF3IP3 LCK GTF3C1

5.62e-05200173755d65be8f05d4bf37c5dbe54948d2d8ab357d30
ToppCellPND07-28-samps-Lymphocyte-T_cells-T_cells_1|PND07-28-samps / Age Group, Lineage, Cell class and subclass

TRAF3IP3 LCK

9.04e-04118172461a971f3e8047c727b7c6e00d2d64e97d50c6de
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_NKT-T_cells-Erythroid|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRAF3IP3 LCK

9.04e-0411817204355cac58ec046730365d6649aa1e31396901c3
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lhx6|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

EFCAB6 DSC2

9.35e-04120172a4e3f9a83bc52ccc75bcd64b1be4e2c5441f6d1a
ToppCellLPS_only-Lymphocytic_NKT-T_cells-iNKT-MAIT|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRAF3IP3 LCK

9.97e-0412417205e114fcfe84cfc8d92978a4eda6db4d8a616e0e
ToppCellLPS-IL1RA-Lymphocytic_NKT-T_cells-Erythroid|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRAF3IP3 LCK

1.06e-03128172c2045f052cc713e52312eb015825711576fcb6c5
ToppCellLymphoid-T_cells_(Cd4+_Tnaive-Tcm)|World / shred on cell class and cell subclass (v4)

TRAF3IP3 LCK

1.13e-0313217214a371fc7e47a45b84f10a939163d030ad967de5
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell|343B / Donor, Lineage, Cell class and subclass (all cells)

TRAF3IP3 LCK

1.20e-03136172b4a934feea46eeb10d407d1545bd225173078792
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-OPC_related-Oligodendrocyte/OPC|GW26 / Sample Type, Dataset, Time_group, and Cell type.

DSC3 PLCD3

1.21e-031371728ce463d1d74ac0ce80b812217d6bd76a788f14d2
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-OPC_related|GW26 / Sample Type, Dataset, Time_group, and Cell type.

DSC3 PLCD3

1.21e-03137172264d5e06c37d1a9ef7748091b67d2a5aa803096e
ToppCellLPS-IL1RA-Hematopoietic_Mast-Mast_cells-T-cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRAF3IP3 LCK

1.23e-0313817210c263c58b83a018791f77098f18927d904cb13b
ToppCellLPS-IL1RA-Lymphocytic_NKT-iNKT/MAIT-T-cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRAF3IP3 LCK

1.25e-03139172ecc2a6ecc27748c50885cd4f0ad8a8cd1252aee6
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFCAB6 LCK

1.27e-031401727ca49bd7ba9381e75c10f888775df17e5d46804d
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFCAB6 LCK

1.27e-031401721a31bc33d5723b9bc528cc0047ca5f4c80531c7a
ToppCellLPS-IL1RA-Hematopoietic_Mast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRAF3IP3 LCK

1.30e-03142172f7d0d5ca9fc3dd929d4fdd59b71bfa623007e992
ToppCellLPS-IL1RA-Hematopoietic_Mast-Mast_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRAF3IP3 LCK

1.30e-031421722a9a070e7c53ac593d46c6c5f6983f07d4413501
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRAF3IP3 LCK

1.36e-03145172a9f5a32abcf3eb2c66bd65f2521a6dd4ce56c635
ToppCellLPS-IL1RA+antiTNF-Hematopoietic_Mast-Mast_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRAF3IP3 LCK

1.38e-03146172a5c84ad44d6ffb25028a4fd5454fd5de81b16a5e
ToppCellLPS-IL1RA+antiTNF-Hematopoietic_Mast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRAF3IP3 LCK

1.38e-031461728133037881c15e75637fc616091a7055488dd5fc
ToppCellP15-Hematopoietic|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TRAF3IP3 LCK

1.38e-031461722b3e6ff6069573ee213000aeab5de9a33afc1a99
ToppCellLPS-antiTNF-Hematopoietic_Mast-Mast_cells-T-cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRAF3IP3 LCK

1.40e-031471721ecd7c084e73eb6fae1ab1f9aae17115d3d62cbd
ToppCellControl-Lymphocytic_NKT-iNKT/MAIT-T-cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRAF3IP3 LCK

1.42e-03148172003e10bf477984248211b99d75daa8f7dcdb12c8
ToppCellPND01-Immune-Immune_Lymphocytic_T/NK|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRAF3IP3 LCK

1.42e-03148172b78dac56b333bf901136ccafb0999f345e978f51
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRAF3IP3 LCK

1.42e-031481723aa47398cb805c6c6e16b375cc3e9c7f04bb91f4
ToppCellLPS-antiTNF-Hematopoietic_Mast-Mast_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRAF3IP3 LCK

1.43e-0314917259aa1f2a5cbeba64c4529fb05f544db17fd8b188
ToppCellLPS-antiTNF-Hematopoietic_Mast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRAF3IP3 LCK

1.43e-031491721527cdd98a2734cbf8ce4c6170557280b71c55cb
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRAF3IP3 LCK

1.43e-031491724fda987bc7bb6d1dbd41b8f1f8c1bc59613255a8
ToppCellfacs-Lung-3m-Hematologic-Lymphocytic_NK_ILC|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TRPV5 LCK

1.45e-031501721f83e3be3f94aefe991a3ccd292c2d11ddef858e
ToppCellLPS_only-Hematopoietic_Mast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRAF3IP3 LCK

1.45e-031501722c5078a1f769ba8153dee756b53d28eb7b434a96
ToppCellLPS_only-Hematopoietic_Mast-Mast_cells-T-cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRAF3IP3 LCK

1.45e-03150172ccb782fbcb3122266354a112a9a850506664f44d
ToppCellfacs-Lung-3m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TRPV5 LCK

1.45e-03150172cd666db614bc1b43d71e8eb7bf38cae4d580be80
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|390C / Donor, Lineage, Cell class and subclass (all cells)

TRAF3IP3 LCK

1.45e-03150172fdbfc8f743cf848978cf0488493f6df60be53982
ToppCellLPS_only-Hematopoietic_Mast-Mast_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRAF3IP3 LCK

1.45e-031501727290e9a812b1b2f919e67ccde0acf52687ab138f
ToppCellfacs-Lung-3m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TRPV5 LCK

1.45e-03150172f6ed3e7b36014d1e429b255b0027d89865e1ac07
ToppCellLymphoid|World / shred on cell class and cell subclass (v4)

TRAF3IP3 LCK

1.47e-03151172d7577b2416b91a8be0198dea703385f86f816059
ToppCellP15-Hematopoietic-Immune|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TRAF3IP3 LCK

1.47e-03151172a54045cac65a66197e3ad2b002fa6c511102834a
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRAF3IP3 LCK

1.47e-031511721525422afadff68a1525ced6d5db45fdea450678
ToppCellLPS-IL1RA+antiTNF-Hematopoietic_Mast-Mast_cells-T-cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRAF3IP3 LCK

1.47e-03151172b85a763459a0f019d1f9975d09b9f2247d62c9d3
ToppCell343B-Lymphocytic-NK_cells-NK_cell_B0|343B / Donor, Lineage, Cell class and subclass (all cells)

TRAF3IP3 LCK

1.47e-03151172563439b0278776b82c1836c3de9fa80d1a4109af
ToppCellP15-Hematopoietic-Immune-immune_cell_unspecified|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TRAF3IP3 LCK

1.47e-031511726b905d309f2a9b8828399b36f4942aec8696bee6
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRAF3IP3 LCK

1.49e-03152172ed6df77ba04b715e12c2e1591b4a1e894ca49d25
ToppCellLeuk-UTI-Lymphocyte-T_NK-Treg|Leuk-UTI / Disease, Lineage and Cell Type

TRAF3IP3 LCK

1.51e-03153172b24c693b142206d13b29c96faa7f79a1a22bc2ef
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPV5 TRPV6

1.51e-031531729b6675ace8a83c8d446b722301d0ec4e6840f3fc
ToppCellPBMC-Control-cDC_2|Control / Compartment, Disease Groups and Clusters

EFCAB6 LCK

1.51e-031531724ee37266b0054f276c7a73ab9220f681b9d74c71
ToppCellRV-17._Lymphocyte|RV / Chamber and Cluster_Paper

TRAF3IP3 LCK

1.51e-03153172e1ea621184014415870e00d511386b8cc3e0833b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRPV5 TRPV6

1.51e-0315317279c4f4ccdc8249c8461075c73491bc3b2d13344a
ToppCell356C-Lymphocytic-NK_cells-NK_cell_D2|356C / Donor, Lineage, Cell class and subclass (all cells)

TRAF3IP3 LCK

1.51e-031531725fb7d92cddc816c64071465e955ed0ea3bb45316
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|367C / Donor, Lineage, Cell class and subclass (all cells)

LCK GTF3C1

1.53e-03154172a39877cdf7b441b5c953f744ed30f1d5acf4ea19
ToppCellNS-critical-d_0-4-Lymphoid-NKT|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TRAF3IP3 LCK

1.53e-0315417208ffa4b6f4a1c3de037acf9d30bd14c195738ad9
ToppCellP28-Hematopoietic|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TRAF3IP3 LCK

1.53e-0315417213980ae1957b05350c11171c9c118decfe998d3d
ToppCell343B-Lymphocytic-NK_cells-NK_cell_B|343B / Donor, Lineage, Cell class and subclass (all cells)

TRAF3IP3 LCK

1.53e-03154172886e7cd01cb48ca3e97debeea2b1f100b09d47e6
ToppCellAdult-Epithelial-basal_cell-D122|Adult / Lineage, Cell type, age group and donor

DSC3 TRPV6

1.53e-0315417238d346402417960044ae999e61f0092b46f2b591
ToppCell18-Distal-Immune-Immune|Distal / Age, Tissue, Lineage and Cell class

TRAF3IP3 LCK

1.53e-03154172ecfaed6fbffd1305a2216d48ecb33d8a182a9dd9
ToppCellCOVID-19-kidney-Mito-rich_(Imm)|COVID-19 / Disease (COVID-19 only), tissue and cell type

TRAF3IP3 LCK

1.53e-03154172b437acc11e35fe05389e552d507f6f76e20cc102
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPV5 TRPV6

1.53e-031541729316732964a819a8e935a952faa3823109f90b77
ToppCellPND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EFCAB6 LCK

1.55e-031551721fb49b48e34e740118908951e079ea2a9994ae4f
ToppCellE18.5-Immune-Immune_Lymphocytic_T/NK|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRAF3IP3 LCK

1.55e-03155172efe69145910c5e049d0ed30699c26ef963e0a285
ToppCellRV-17._Lymphocyte|World / Chamber and Cluster_Paper

TRAF3IP3 LCK

1.55e-03155172189276a3b400b2202e6681e23732e6452bfe704e
ToppCellE18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRAF3IP3 LCK

1.55e-03155172d8e9f355ce933f6383c3d1e35ff55235a95c7fcd
ToppCellPND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EFCAB6 LCK

1.55e-031551724ae91bc7dbb9f713a1f110c17834b1d89f1b28db
ToppCell3'_v3-Lung-Lymphocytic_Invariant-Inducer-like-MAIT|Lung / Manually curated celltypes from each tissue

LCK GTF3C1

1.55e-0315517272c61be0a8d3ee10600a33c58fb01c35fd3f14d4
ToppCellPND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EFCAB6 LCK

1.55e-03155172fdcc8a475156329b3594d5ed22ba03538305327c
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

TRAF3IP3 LCK

1.14e-0350112GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_UNASSIGNED_1
ComputationalNeighborhood of ITGAL

TRAF3IP3 VPS16

1.37e-0355112GNF2_ITGAL
DrugPiperidino acetanilide

DSC2 DSC3

1.10e-057172CID000078402
Drug3,5-bis(trifluoromethyl)pyrazole

TRPV5 TRPV6

2.35e-0510172CID000518991
DrugAC1MMLID

TRPV5 TRPV6 GTF3C1

4.17e-0592173CID000013245
DrugAC1LWLPQ

TRPV5 TRPV6

6.26e-0516172CID001778727
Diseasedesmocollin-2 measurement

DSC2 DSC3

2.75e-065162EFO_0021936
Diseasearrhythmogenic right ventricular cardiomyopathy (implicated_via_orthology)

DSC2 DSC3

2.75e-065162DOID:0050431 (implicated_via_orthology)
Diseasebronchopulmonary dysplasia

DSC2 DSC3

2.69e-0445162MONDO_0019091
Diseaseanxiety measurement

TRPV5 TRPV6

1.54e-03108162EFO_0009863
Diseaseneutrophil count

TRAF3IP3 PHTF1 MRPS14 GTF3C1

5.55e-031382164EFO_0004833

Protein segments in the cluster

PeptideGeneStartEntry
EPRMQIICRRRWREP

C8orf86

71

Q6ZUL3
RRAKRRWAPIPCSML

DSC2

131

Q02487
MLRVLCLLRPWRPLR

ECHDC2

1

Q86YB7
QLMRLCWKERPEDRP

LCK

471

P06239
RRAKRRWAPIPCSMQ

DSC3

131

Q14574
LRIQPKIVHCWRPMR

EFCAB6

1426

Q5THR3
RIRVLREMVPEAWRC

CA5BP1

141

Q8WTZ4
RPMRRLCLEKIFPHW

TCAIM

6

Q8N3R3
PEDWRARLKRRKMAP

FNBP4

1001

Q8N3X1
RRQCGRWLPVLMVVI

TRAF3IP3

521

Q9Y228
PPERCKLAREIRWRL

ZNF503-AS2

156

A6NEH8
CVMTSRPRGVKRRWR

MRPS14

91

O60783
PIIKRRQCRPEIRMW

PHTF1

231

Q9UMS5
MLCGRWRRCRRPPEE

PLCD3

1

Q8N3E9
TDRRLRPWCREQPTM

SMRP1

221

Q8NCR6
IRAPPKQMVWCSRPR

VPS16

261

Q9H269
TVMLERKLPRCLWPR

TRPV6

641

Q9H1D0
CIRKRWLRKPRPVSL

GTF3C1

2046

Q12789
TVMLERKLPRCLWPR

TRPV5

601

Q9NQA5