Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone binding	BAZ2A KMT5C ZNF689 TSPYL5 CHD1 CHD7 HDGFL2	1.59e-05	265	61	7	GO:0042393
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2C SETD1B	2.54e-04	8	61	2	GO:0140945
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2C SETD1B	4.07e-04	10	61	2	GO:0140999
GeneOntologyMolecularFunction	histone modifying activity	KMT2C SETD1B HIPK4 JADE2 KMT5C	6.70e-04	229	61	5	GO:0140993
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	KMT2C SETD1B KMT5C	1.18e-03	68	61	3	GO:0016279
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	LIG1 RTEL1 NTHL1 CHD1 CHD7	1.22e-03	262	61	5	GO:0140097
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	KMT2C SETD1B KMT5C	1.23e-03	69	61	3	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	KMT2C SETD1B KMT5C	1.34e-03	71	61	3	GO:0042054
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2C SETD1B	1.68e-03	20	61	2	GO:0042800
Domain	NPIP	NPIPB13 NPIPB3 NPIPB5	1.24e-05	14	62	3	IPR009443
Domain	AT_hook	KMT2C BAZ2A AHDC1	9.63e-05	27	62	3	SM00384
Domain	AT_hook_DNA-bd_motif	KMT2C BAZ2A AHDC1	9.63e-05	27	62	3	IPR017956
Domain	DNA/RNA_helicase_DEAH_CS	RTEL1 CHD1 CHD7	2.11e-04	35	62	3	IPR002464
Domain	DEAH_ATP_HELICASE	RTEL1 CHD1 CHD7	2.71e-04	38	62	3	PS00690
Domain	SET	KMT2C SETD1B KMT5C	3.39e-04	41	62	3	PF00856
Domain	-	NKX2-6 DNAJC1 DUX1 SIX3 RAX CUX1	3.46e-04	283	62	6	1.10.10.60
Domain	SET	KMT2C SETD1B KMT5C	4.78e-04	46	62	3	SM00317
Domain	Methyl_CpG_DNA-bd	BAZ2A MBD6	5.85e-04	11	62	2	IPR001739
Domain	MBD	BAZ2A MBD6	5.85e-04	11	62	2	PF01429
Domain	DNA-bd_dom	BAZ2A MBD6	5.85e-04	11	62	2	IPR016177
Domain	MBD	BAZ2A MBD6	5.85e-04	11	62	2	SM00391
Domain	MBD	BAZ2A MBD6	5.85e-04	11	62	2	PS50982
Domain	SET_dom	KMT2C SETD1B KMT5C	6.11e-04	50	62	3	IPR001214
Domain	SET	KMT2C SETD1B KMT5C	6.11e-04	50	62	3	PS50280
Domain	Homeodomain-like	NKX2-6 DNAJC1 DUX1 SIX3 RAX CUX1	8.03e-04	332	62	6	IPR009057
Domain	-	ELOA HDGFL2	8.26e-04	13	62	2	1.20.930.10
Domain	TFIIS_N	ELOA HDGFL2	9.62e-04	14	62	2	IPR017923
Domain	Homeobox	NKX2-6 DUX1 SIX3 RAX CUX1	1.07e-03	234	62	5	PF00046
Domain	HOMEOBOX_1	NKX2-6 DUX1 SIX3 RAX CUX1	1.11e-03	236	62	5	PS00027
Domain	HOX	NKX2-6 DUX1 SIX3 RAX CUX1	1.13e-03	237	62	5	SM00389
Domain	HOMEOBOX_2	NKX2-6 DUX1 SIX3 RAX CUX1	1.18e-03	239	62	5	PS50071
Domain	Homeobox_dom	NKX2-6 DUX1 SIX3 RAX CUX1	1.18e-03	239	62	5	IPR001356
Domain	Post-SET_dom	KMT2C SETD1B	1.26e-03	16	62	2	IPR003616
Domain	PostSET	KMT2C SETD1B	1.26e-03	16	62	2	SM00508
Domain	AT_hook	KMT2C BAZ2A	1.26e-03	16	62	2	PF02178
Domain	POST_SET	KMT2C SETD1B	1.26e-03	16	62	2	PS50868
Domain	PHD	KMT2C BAZ2A JADE2	1.98e-03	75	62	3	PF00628
Domain	Znf_PHD-finger	KMT2C BAZ2A JADE2	2.30e-03	79	62	3	IPR019787
Domain	EPHD	KMT2C JADE2	2.40e-03	22	62	2	PS51805
Domain	Chromo_domain	CHD1 CHD7	2.85e-03	24	62	2	IPR023780
Domain	PHD	KMT2C BAZ2A JADE2	3.23e-03	89	62	3	SM00249
Domain	Chromo	CHD1 CHD7	3.35e-03	26	62	2	PF00385
Domain	Homeobox_CS	NKX2-6 DUX1 RAX CUX1	3.39e-03	186	62	4	IPR017970
Domain	Znf_PHD	KMT2C BAZ2A JADE2	3.44e-03	91	62	3	IPR001965
Domain	CHROMO_1	CHD1 CHD7	3.88e-03	28	62	2	PS00598
Domain	CHROMO_2	CHD1 CHD7	3.88e-03	28	62	2	PS50013
Domain	FHA	SNIP1 AFDN	3.88e-03	28	62	2	SM00240
Domain	ZF_PHD_2	KMT2C BAZ2A JADE2	3.88e-03	95	62	3	PS50016
Domain	ZF_PHD_1	KMT2C BAZ2A JADE2	4.00e-03	96	62	3	PS01359
Domain	HMGI/Y_DNA-bd_CS	KMT2C BAZ2A	4.74e-03	31	62	2	IPR000637
Domain	FHA_DOMAIN	SNIP1 AFDN	4.74e-03	31	62	2	PS50006
Domain	FHA	SNIP1 AFDN	4.74e-03	31	62	2	PF00498
Domain	SNF2_N	CHD1 CHD7	5.04e-03	32	62	2	IPR000330
Domain	Chromodomain-like	CHD1 CHD7	5.04e-03	32	62	2	IPR016197
Domain	SNF2_N	CHD1 CHD7	5.04e-03	32	62	2	PF00176
Domain	Chromo/shadow_dom	CHD1 CHD7	5.36e-03	33	62	2	IPR000953
Domain	CHROMO	CHD1 CHD7	5.36e-03	33	62	2	SM00298
Domain	FHA_dom	SNIP1 AFDN	6.35e-03	36	62	2	IPR000253
Domain	-	SNIP1 AFDN	6.35e-03	36	62	2	2.60.200.20
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SNIP1 KMT2C URB1 DST BAZ2A POLDIP3 NTHL1 GPATCH1 CHD7 DNAJC1 HDGFL2 AHDC1 RCC2 ZMYM4 CUX1 RPL15	2.31e-09	1294	67	16	30804502
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SNIP1 KMT2C TMEM161A URB1 DST BAZ2A NTHL1 AFDN CHD1 CHD7 DNAJC1 HDGFL2 AHDC1 RCC2 ZMYM4	1.26e-07	1497	67	15	31527615
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	ELOA BAZ2A POLDIP3 GPATCH1 GIGYF2 AFDN CHD1 CHD7 HDGFL2 RCC2 ZMYM4 CUX1	2.54e-07	954	67	12	36373674
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	URB1 DST BAZ2A POLDIP3 GIGYF2 AFDN CHD1 CHD7 RCC2 RPL15	4.82e-07	653	67	10	22586326
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	ELOA DST BAZ2A POLDIP3 GPATCH1 EGLN1 GIGYF2 CHD1 HDGFL2 RCC2 RPL15	1.61e-06	934	67	11	33916271
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ELOA BAZ2A RADX NTHL1 CHD1 CHD7 HDGFL2 ZMYM4 CUX1	2.49e-06	608	67	9	36089195
Pubmed	Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro.	KMT2C SETD1B KMT5C	3.06e-06	15	67	3	35907431
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	SNIP1 LIG1 KMT2C CHD1 CHD7 HDGFL2 AHDC1 ZMYM4	3.35e-06	469	67	8	27634302
Pubmed	Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution.	RTEL1 POLDIP3	3.66e-06	2	67	2	32561545
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	KMT2C URB1 DST RTEL1 GIGYF2 CHD7	4.92e-06	225	67	6	12168954
Pubmed	Divergent origins and concerted expansion of two segmental duplications on chromosome 16.	NPIPB3 NPIPB5	1.10e-05	3	67	2	11948212
Pubmed	Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring.	MAGI1 DDN	1.10e-05	3	67	2	16464232
Pubmed	Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.	LIG1 RTEL1 POLDIP3 AHDC1 ZMYM4	1.36e-05	157	67	5	30686591
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	ELOA BAZ2A POLDIP3 GPATCH1 CHD7 HDGFL2	1.81e-05	283	67	6	30585729
Pubmed	Function of Rx, but not Pax6, is essential for the formation of retinal progenitor cells in mice.	SIX3 RAX	2.19e-05	4	67	2	11105055
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	URB1 JADE2 POLDIP3 GIGYF2 CHD1 AHDC1 ZMYM4 CUX1 RPL15	3.49e-05	847	67	9	35850772
Pubmed	Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6.	SIX3 RAX	3.64e-05	5	67	2	11003833
Pubmed	The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation.	SIX3 RAX	3.64e-05	5	67	2	19146846
Pubmed	Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis.	SIX3 RAX	3.64e-05	5	67	2	37452018
Pubmed	Microphthalmia/Anophthalmia/Coloboma Spectrum – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	CHD7 SIX3 RAX	3.92e-05	34	67	3	20301552
Pubmed	A human MAP kinase interactome.	MAGI1 KMT2C DST JADE2 GIGYF2 CUX1 ARHGAP33	4.20e-05	486	67	7	20936779
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	DST UBXN7 DDN MTCL1	4.46e-05	101	67	4	9872452
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	URB1 GPATCH1 GIGYF2 AFDN RSPO1	4.53e-05	202	67	5	24639526
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KMT2C URB1 SETD1B DST KMT5C HMGXB3 MBD6 AHDC1 CLDN23 ARHGAP33	4.83e-05	1105	67	10	35748872
Pubmed	Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium.	SIX3 RAX	5.46e-05	6	67	2	11641222
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	KMT2C BAZ2A JADE2 EGLN1 AFDN HMGXB3 RAX CUX1	6.48e-05	709	67	8	22988430
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	ELOA RTEL1 POLDIP3 CHD1 ZMYM4	7.09e-05	222	67	5	37071664
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KMT2C DST JADE2 UBXN7 HMGXB3 RCC2 ZMYM4	7.16e-05	529	67	7	14621295
Pubmed	Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein.	SIX3 CUX1	7.63e-05	7	67	2	18836447
Pubmed	rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina.	SIX3 RAX	7.63e-05	7	67	2	9096350
Pubmed	An Eye Organoid Approach Identifies Six3 Suppression of R-spondin 2 as a Critical Step in Mouse Neuroretina Differentiation.	SIX3 RAX	7.63e-05	7	67	2	29117559
Pubmed	Human transcription factor protein interaction networks.	KMT2C DST RADX POLDIP3 UBXN7 GIGYF2 CHD7 MBD6 RCC2 ZMYM4 CUX1	8.40e-05	1429	67	11	35140242
Pubmed	Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.	CHD1 HDGFL2 AHDC1 ZMYM4	9.92e-05	124	67	4	20850016
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2C SETD1B	1.02e-04	8	67	2	23130995
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2C SETD1B	1.02e-04	8	67	2	22266653
Pubmed	The homeobox gene Hesx1 is required in the anterior neural ectoderm for normal forebrain formation.	SIX3 RAX	1.02e-04	8	67	2	10882526
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	LIG1 DST SCARF2 GPATCH1 EGLN1 AFDN CUX1 RPL15	1.22e-04	777	67	8	35844135
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SNIP1 KMT2C SETD1B HDGFL2 RCC2	1.26e-04	251	67	5	31076518
Pubmed	Genomic analysis of mouse retinal development.	SLC6A11 DST BAZ2A POLDIP3 SIX3 HDGFL2 RAX ZMYM4 RPL15	1.30e-04	1006	67	9	15226823
Pubmed	exma: an X-linked insertional mutation that disrupts forebrain and eye development.	SIX3 RAX	1.30e-04	9	67	2	11956759
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2C SETD1B	1.30e-04	9	67	2	22665483
Pubmed	Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina.	SIX3 RAX	1.30e-04	9	67	2	15569927
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	DST GIGYF2 CHD7 RBBP8NL ZMYM4 CUX1	1.56e-04	418	67	6	34709266
Pubmed	Mutational screening of 10 genes in Chinese patients with microphthalmia and/or coloboma.	SIX3 RAX	1.63e-04	10	67	2	20057906
Pubmed	Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins.	SIX3 RAX	1.63e-04	10	67	2	11069920
Pubmed	New nomenclature for chromatin-modifying enzymes.	KMT2C SETD1B KMT5C	1.86e-04	57	67	3	18022353
Pubmed	Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.	SNIP1 ZNF469 RSPO1	1.95e-04	58	67	3	24144296
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	ELOA POLDIP3 UBXN7 HDGFL2	1.96e-04	148	67	4	32538781
Pubmed	Natural antisense transcripts associated with genes involved in eye development.	SIX3 RAX	1.99e-04	11	67	2	15703187
Pubmed	The Homeodomain Transcription Factors Vax1 and Six6 Are Required for SCN Development and Function.	SIX3 RAX	1.99e-04	11	67	2	31705443
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	ELOA DST POLDIP3 TSPYL5 CHD7 AHDC1 RCC2 ARHGAP33 RPL15	2.24e-04	1082	67	9	38697112
Pubmed	Identification of genes expressed in retinal progenitor/stem cell colonies isolated from the ocular ciliary body of adult mice.	SIX3 RAX	2.38e-04	12	67	2	16765103
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2C SETD1B	2.38e-04	12	67	2	27563068
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	SETD1B BAZ2A CHD7 MBD6	2.46e-04	157	67	4	30186101
Pubmed	Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development.	SIX3 RAX	2.81e-04	13	67	2	12569128
Pubmed	Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide Exchange Factors for Rap1 Small GTPase, in Formation of Apical Surface Adherens Junctions and Neural Progenitor Development in the Mouse Cerebral Cortex.	AFDN CUX1	2.81e-04	13	67	2	27390776
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	LIG1 DST POLDIP3 CHD1 HDGFL2 CUX1	3.00e-04	472	67	6	38943005
Pubmed	Cell-autonomous involvement of Mab21l1 is essential for lens placode development.	SIX3 RAX	3.28e-04	14	67	2	12642482
Pubmed	Impairment of radial glial scaffold-dependent neuronal migration and formation of double cortex by genetic ablation of afadin.	AFDN CUX1	3.78e-04	15	67	2	25988834
Pubmed	Rax is a selector gene for mediobasal hypothalamic cell types.	SIX3 RAX	3.78e-04	15	67	2	23283339
Pubmed	Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon.	AFDN CUX1	3.78e-04	15	67	2	25100583
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	KMT2C SETD1B ZNF689 MBD6 AHDC1 ZMYM4	3.86e-04	495	67	6	27705803
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	MAGI1 DST EGLN1 GIGYF2 AFDN RCC2 RPL15	4.24e-04	708	67	7	39231216
Pubmed	SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.	KMT2C SETD1B	4.31e-04	16	67	2	23870121
Pubmed	SOX2 Regulates Neuronal Differentiation of the Suprachiasmatic Nucleus.	SIX3 RAX	4.31e-04	16	67	2	35008655
Pubmed	H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.	KMT2C SETD1B	4.31e-04	16	67	2	24368734
Pubmed	Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus.	BAZ2A SIX3 RAX	4.51e-04	77	67	3	21525287
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	ZNF469 MXRA5 DST CUX1	4.76e-04	187	67	4	26460568
Pubmed	Lhx2 is required for patterning and expansion of a distinct progenitor cell population committed to eye development.	SIX3 RAX	4.88e-04	17	67	2	21886788
Pubmed	Screening E3 substrates using a live phage display library.	NPIPB3 RPL15	4.88e-04	17	67	2	24124579
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MAGI1 DST DDN GIGYF2 AFDN CHD7 MTCL1 CUX1	5.16e-04	963	67	8	28671696
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ELOA RADX POLDIP3 EGLN1 CHD1 CHD7 DNAJC1	5.22e-04	733	67	7	34672954
Pubmed	Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.	NPIPB4 JADE2 NPIPB3	5.62e-04	83	67	3	9039502
Pubmed	Interaction network of human early embryonic transcription factors.	KMT2C CHD7 MBD6 AHDC1 ZMYM4	5.89e-04	351	67	5	38297188
Pubmed	Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation.	SIX3 RAX	6.12e-04	19	67	2	18697938
Pubmed	Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate.	SIX3 RAX	6.12e-04	19	67	2	20890044
Pubmed	The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.	SNIP1 EGLN1 HDGFL2 RCC2	6.48e-04	203	67	4	35012549
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KMT2C BAZ2A GIGYF2 AFDN ZMYM4 CUX1	6.65e-04	549	67	6	38280479
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	SNIP1 POLDIP3 NTHL1 MTCL1 ZMYM4	6.68e-04	361	67	5	26167880
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	KMT2C SETD1B	6.79e-04	20	67	2	29785026
Pubmed	Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH.	SIX3 RAX	6.79e-04	20	67	2	16854970
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	LIG1 ELOA BAZ2A GIGYF2 AFDN CHD7 ZMYM4	7.19e-04	774	67	7	15302935
Pubmed	OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.	POLDIP3 RCC2	7.50e-04	21	67	2	30662561
Pubmed	Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes.	SIX3 RAX	7.50e-04	21	67	2	29679559
Pubmed	Optic vesicle morphogenesis requires primary cilia.	SIX3 RAX	7.50e-04	21	67	2	32169553
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	URB1 DST POLDIP3 GIGYF2 AFDN CHD1 RCC2 RPL15	7.71e-04	1024	67	8	24711643
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	SCARF2 GPATCH1 GIGYF2 AFDN DNAJC1	7.92e-04	375	67	5	32788342
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	GPATCH1 GIGYF2 AFDN CUX1	8.03e-04	215	67	4	35973513
Pubmed	Rap1 GTPases Are Master Regulators of Neural Cell Polarity in the Developing Neocortex.	AFDN CUX1	8.24e-04	22	67	2	26733533
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	KMT2C SETD1B	8.24e-04	22	67	2	26886794
Pubmed	Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development.	RSPO1 RAX	9.01e-04	23	67	2	16893423
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	MAGI1 GIGYF2	9.01e-04	23	67	2	9225980
Pubmed	A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development.	SIX3 RAX	9.01e-04	23	67	2	22792072
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	SETD1B RADX POLDIP3 CHD7 ZCCHC2 ZMYM4	9.49e-04	588	67	6	38580884
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	POLDIP3 GIGYF2 CHD1 MTCL1 HDGFL2 RPL15	1.06e-03	601	67	6	33658012
Pubmed	Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations.	LIG1 NTHL1	1.07e-03	25	67	2	20226869
Pubmed	The ciliogenic transcription factor RFX3 regulates early midline distribution of guidepost neurons required for corpus callosum development.	SIX3 CUX1	1.07e-03	25	67	2	22479201
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	URB1 SETD1B DST BAZ2A POLDIP3 AFDN CHD1 CHD7 RPL15	1.12e-03	1353	67	9	29467282
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SETD1B BAZ2A DDN GIGYF2 MTCL1	1.14e-03	407	67	5	12693553
Pubmed	Tissue-specific regulation of retinal and pituitary precursor cell proliferation.	SIX3 RAX	1.15e-03	26	67	2	12130660
Interaction	CBX3 interactions	LIG1 ELOA BAZ2A KMT5C ZNF689 UBXN7 CHD1 CHD7 HDGFL2 AHDC1 ZMYM4 CUX1	6.35e-07	646	63	12	int:CBX3
Interaction	MEN1 interactions	KMT2C URB1 SETD1B BAZ2A JADE2 GPATCH1 UBXN7 GIGYF2 AFDN CHD1 AHDC1 ZMYM4 CUX1 RPL15	2.68e-06	1029	63	14	int:MEN1
Interaction	H3-3A interactions	ELOA KMT2C SETD1B BAZ2A RADX NTHL1 TSPYL5 CHD1 CHD7 HDGFL2 ZMYM4 CUX1	2.97e-06	749	63	12	int:H3-3A
Interaction	H2BC8 interactions	ELOA BAZ2A RADX UBXN7 CHD1 CHD7 HDGFL2 RCC2 ZMYM4 CUX1	1.10e-05	576	63	10	int:H2BC8
Interaction	H3C1 interactions	ELOA KMT2C SETD1B BAZ2A EGLN1 TSPYL5 CHD1 CHD7 HDGFL2 RCC2 ZMYM4 CUX1	1.93e-05	901	63	12	int:H3C1
Interaction	PHF20 interactions	LIG1 KMT2C SETD1B JADE2	2.26e-05	53	63	4	int:PHF20
Interaction	SNRNP40 interactions	SNIP1 URB1 BAZ2A POLDIP3 GPATCH1 UBXN7 CHD1 HDGFL2 AHDC1 RCC2	2.62e-05	637	63	10	int:SNRNP40
Interaction	TERF2IP interactions	SNIP1 ELOA BAZ2A RADX UBXN7 CHD1 CHD7 ZMYM4 CUX1	5.16e-05	552	63	9	int:TERF2IP
Interaction	SMC5 interactions	ELOA BAZ2A POLDIP3 GPATCH1 GIGYF2 AFDN CHD1 CHD7 HDGFL2 RCC2 ZMYM4 CUX1	5.34e-05	1000	63	12	int:SMC5
Interaction	AKR7L interactions	ELOA DST GIGYF2 HDGFL2	7.61e-05	72	63	4	int:AKR7L
Interaction	SIRT7 interactions	URB1 DST BAZ2A POLDIP3 GIGYF2 AFDN CHD1 CHD7 RCC2 RPL15	9.63e-05	744	63	10	int:SIRT7
Interaction	NUP43 interactions	SETD1B DST BAZ2A GPATCH1 UBXN7 CHD1 AHDC1 RCC2 ZMYM4	1.33e-04	625	63	9	int:NUP43
Interaction	PAX6 interactions	KMT2C UBXN7 CHD7 SIX3 RAX ZMYM4 CUX1	1.42e-04	366	63	7	int:PAX6
Interaction	H3C3 interactions	ELOA BAZ2A RADX CHD1 CHD7 HDGFL2 ZMYM4 CUX1	1.48e-04	495	63	8	int:H3C3
Interaction	CENPA interactions	URB1 BAZ2A UBXN7 CHD1 CHD7 HDGFL2 CUX1	1.70e-04	377	63	7	int:CENPA
Interaction	ASH2L interactions	KMT2C SETD1B JADE2 CHD7 RCC2 RPL15	1.77e-04	265	63	6	int:ASH2L
Interaction	NAA40 interactions	ELOA DST BAZ2A POLDIP3 GPATCH1 EGLN1 GIGYF2 CHD1 HDGFL2 RCC2 RPL15	2.01e-04	978	63	11	int:NAA40
Cytoband	16p12.2	NPIPB4 NPIPB3 NPIPB5	2.13e-05	37	66	3	16p12.2
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2C SETD1B KMT5C	6.17e-05	34	41	3	487
GeneFamily	Zinc fingers CXXC-type\|Methyl-CpG binding domain containing	BAZ2A MBD6	2.72e-04	11	41	2	1025
GeneFamily	DNA helicases	RTEL1 CHD7	6.68e-04	17	41	2	1167
GeneFamily	PHD finger proteins	KMT2C BAZ2A JADE2	1.11e-03	90	41	3	88
GeneFamily	Ataxins\|Trinucleotide repeat containing	MAGI1 GIGYF2	1.46e-03	25	41	2	775
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	CHD7 DNAJC1	6.43e-03	53	41	2	532
Coexpression	LIM_MAMMARY_LUMINAL_PROGENITOR_DN	DST SCARF2 CUX1	5.20e-06	14	65	3	M2576
Coexpression	LIM_MAMMARY_LUMINAL_PROGENITOR_DN	DST SCARF2 CUX1	5.20e-06	14	65	3	MM961
Coexpression	GSE27786_CD4_TCELL_VS_ERYTHTROBLAST_UP	NTHL1 CHD7 CCDC115 ZCCHC2 ZMYM4 ZNF707	1.04e-05	200	65	6	M4827
Coexpression	GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP	SNIP1 SETD1B ALKAL1 CCDC115 CUX1	1.74e-05	129	65	5	M423
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC6A11 CHRNA6 TRPM5 BRME1 RBBP8NL	1.29e-06	127	66	5	5b0adbcafad31a6759c9bdce2f7f9591a8edc450
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MAGI1 NPIPB4 GPATCH1 ZCCHC2 ZNF707	4.52e-06	164	66	5	d6806deabf5f5c355934387be2baae125ac33fb8
ToppCell	CV-Severe-7\|CV / Virus stimulation, Condition and Cluster	URB1 DST NPIPB3 CHD7 NPIPB5	6.37e-06	176	66	5	3de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	URB1 DST NPIPB3 CHD7 NPIPB5	6.55e-06	177	66	5	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-Immature_INs\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	MAGI1 DST AFDN CHD7 SIX3	9.24e-06	190	66	5	842760bfe0a52e67bad800efa7d99448a4a23ebb
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KMT2C NPIPB4 NPIPB3 NPIPB5 CUX1	9.97e-06	193	66	5	779276e775cb2492e8dd36436295a536084a6415
Disease	skin neoplasm	BCL2L12 RCC2 CUX1	4.91e-04	74	61	3	EFO_0004198
Disease	Anophthalmia-microphthalmia syndrome	SIX3 RAX	8.61e-04	21	61	2	cv:C5680330
Disease	melanoma	SLC6A11 DNAJC1 RAX CUX1	1.75e-03	248	61	4	C0025202
Disease	keratinocyte carcinoma	TSPYL5 RCC2 CUX1	1.89e-03	118	61	3	EFO_0010176

Protein segments in the cluster

Peptide	Gene	Start	Entry
QRISDRRGSGKPRPK	AFDN	1111	P55196
PREAGLRRRKGPTKT	CCDC115	96	Q96NT0
RRKGKDQPESRRPGS	CUX1	411	P39880
EPAGRRRARPVRSKA	BHLHA9	51	Q7RTU4
ARARGRPRKTKPGSM	BAZ2A	1186	Q9UIF9
GRRGARVTDKEPKPL	ALKAL1	31	Q6UXT8
RRKRFLPKVRAAGDG	ALPK3	1366	Q96L96
PGPVRRRGKVELIKF	BCL2L12	46	Q9HB09
RRKAGRGRKADAGPE	AHDC1	396	Q5TGY3
ERKRRKAGGARRSPP	DDN	126	O94850
PARTDGGRTKKRLDP	DDN	261	O94850
SLVDGEPPMKRRRGR	CHD7	2501	Q9P2D1
KRGRPRTIPRENIKG	CHD1	1111	O14646
GATDARPRRRKPARL	DNAJC1	436	Q96KC8
GDVEPSRKPKRRRAA	NPIPB3	1021	Q92617
RKRGGPAGRKRERPE	RCC2	26	Q9P258
GGRSEQPKARQRRKP	NKX2-6	121	A6NCS4
AAKGRKAKRGSRAPP	MTCL1	156	Q9Y4B5
GDVEPSRKPKRRRAA	NPIPB12	841	F8W0I5
RAHQEKPERPLRGGK	RADX	171	Q6NSI4
EARPARGRKPGSRRE	MBD6	871	Q96DN6
RGRKPGSRREPGRLA	MBD6	876	Q96DN6
AADKRPRGRPRKDGA	KMT2C	31	Q8NEZ4
AAAANGPKRRSPEKR	MAGI1	1341	Q96QZ7
GPKRRSPEKRREGTR	MAGI1	1346	Q96QZ7
RLAGRHKARKPPAGS	HIPK4	481	Q8NE63
RKGEGAFRTRPREPA	KMT5C	236	Q86Y97
IPVLDKGRAGRKRFP	DST	7111	Q03001
RAPELKGRARGKPSL	HMGXB3	496	Q12766
RPGDPARKARGRTRL	JADE2	586	Q9NQC1
KEGQGVGPRVKRRPR	GPATCH1	166	Q9BRR8
GDVEPSRKPKRRRAA	NPIPB5	1046	A8MRT5
GDVEPSRKPKRRRAA	NPIPB4	1051	C9JG80
AVRAPRRGPLGGRKK	HDGFL2	211	Q7Z4V5
EVKRLRGLGDRPKPR	RBBP8NL	121	Q8NC74
KAPASPAERRKGERG	ARHGAP33	566	O14559
PRGLARRPAKGKLAS	CHRNA6	371	Q15825
RRPAKGKLASHGEPR	CHRNA6	376	Q15825
PRRKAADGGHRRALP	BRME1	371	Q0VDD7
RRALPGAADLRPKGA	DOCK8-AS1	236	Q5T8R8
RPKGARADDRRPLRA	DOCK8-AS1	246	Q5T8R8
DRRFEKPGRKDVGRP	GIGYF2	166	Q6Y7W6
GGREKEESPQPRRKR	CUSTOS	131	Q96C57
AKPPRDVRRRQEKFG	ELOA	696	Q14241
PRAGAREPRKAAARR	EGLN1	86	Q9GZT9
PGRRDPQKGRRKRTA	DUX1	86	O43812
SPVKRPGRKAARVLG	LIG1	51	P18858
DERCRRRRKGPSAGP	CLDN23	186	Q96B33
RKRGAAAKGRLNARP	POLDIP3	11	Q9BY77
GDVEPSRKPKRRRAA	NPIPB13	1051	A6NJU9
RPAEEPRGGRKKIRL	RTEL1	866	Q9NZ71
RGNRARGVSRSPPKK	SNIP1	66	Q8TAD8
EELRALAGKPRPRGR	TMEM161A	46	Q9NX61
LAGKPRPRGRKERWA	TMEM161A	51	Q9NX61
PGPLRRREAAAEARK	NTHL1	36	P78549
VRRVPCPEGQKRRKG	RSPO1	201	Q2MKA7
RGRPLGPVDKYRVRK	SIX3	181	O95343
KRDPKGVGVRRRPAR	SETD1B	1011	Q9UPS6
GHRSRKELREKGPPR	SPEGNB	41	A0A087WV53
AKGPRGRKRRPGEAE	URB1	2026	O60287
KERDRRLGARPACPK	RAX	61	Q9Y2V3
DARPGAKAPSRRRRD	ZCCHC2	26	Q9C0B9
RGPRPGARKSADPKR	ZNF707	81	Q96C28
RPGDRRRAEKGPAKR	TRPM5	486	Q9NZQ8
VRRGGRKRPVPKGAT	RPL15	66	P61313
PPRKKSREAAGELGR	SCARF2	851	Q96GP6
GRKPPGHFAAERRRL	VWCE	26	Q96DN2
GGAAPARHPRVKRDK	SLC6A11	31	P48066
KRAPLVFSGKRRAPG	ZNF469	3586	Q96JG9
QGPGKARPSRKRGRR	ZNF689	11	Q96CS4
GAPKRRRPARSIFDG	UBXN7	96	O94888
HRDGFPQPRRRGRKK	ZMYM4	1166	Q5VZL5
RGKGRAKARVRPAPD	TSPYL5	16	Q86VY4
PSKRGRRPGAKALSR	MXRA5	676	Q9NR99