Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	SRGAP2C SRGAP2	1.10e-05	2	69	2	GO:0021816
GeneOntologyBiologicalProcess	pseudopodium assembly	SRGAP2C APC SRGAP2	2.36e-05	17	69	3	GO:0031269
GeneOntologyBiologicalProcess	pseudopodium organization	SRGAP2C APC SRGAP2	3.34e-05	19	69	3	GO:0031268
GeneOntologyCellularComponent	INO80-type complex	EP400 CFDP1 YY1AP1	1.11e-04	28	70	3	GO:0097346
GeneOntologyCellularComponent	nuclear chromosome	BLM FKBP6 EP400 CFDP1 YY1AP1 SMC1B	2.08e-04	254	70	6	GO:0000228
GeneOntologyCellularComponent	synaptonemal complex	BLM FKBP6 SMC1B	4.92e-04	46	70	3	GO:0000795
GeneOntologyCellularComponent	synaptonemal structure	BLM FKBP6 SMC1B	4.92e-04	46	70	3	GO:0099086
GeneOntologyCellularComponent	condensed chromosome	BLM RIF1 FKBP6 CFDP1 APC SMC1B	5.69e-04	307	70	6	GO:0000793
GeneOntologyCellularComponent	cell body fiber	SACS APC	5.96e-04	11	70	2	GO:0070852
GeneOntologyCellularComponent	Swr1 complex	EP400 CFDP1	8.42e-04	13	70	2	GO:0000812
GeneOntologyCellularComponent	dendritic spine head	SYNE1 SRGAP2	1.29e-03	16	70	2	GO:0044327
Domain	srGAP2	SRGAP2C SRGAP2 SRGAP2B	4.62e-08	3	68	3	IPR030252
Domain	FCH	SRGAP2C SRGAP2 SRGAP2B	6.76e-05	22	68	3	PF00611
Domain	FCH	SRGAP2C SRGAP2 SRGAP2B	6.76e-05	22	68	3	SM00055
Domain	FCH_dom	SRGAP2C SRGAP2 SRGAP2B	7.76e-05	23	68	3	IPR001060
Domain	F_BAR	SRGAP2C SRGAP2 SRGAP2B	1.00e-04	25	68	3	IPR031160
Domain	F_BAR	SRGAP2C SRGAP2 SRGAP2B	1.00e-04	25	68	3	PS51741
Domain	DNA/RNA_helicase_DEAH_CS	BLM EP400 DHX29	2.78e-04	35	68	3	IPR002464
Domain	DEAH_ATP_HELICASE	BLM EP400 DHX29	3.55e-04	38	68	3	PS00690
Domain	-	RBM10 RBM5	5.77e-04	10	68	2	4.10.1060.10
Domain	RRM_1	SETD1A RBM10 RBM26 RBM5 RBM34	9.63e-04	208	68	5	PF00076
Domain	RRM	SETD1A RBM10 RBM26 RBM5 RBM34	1.16e-03	217	68	5	SM00360
Domain	RRM_dom	SETD1A RBM10 RBM26 RBM5 RBM34	1.42e-03	227	68	5	IPR000504
Domain	RRM	SETD1A RBM10 RBM26 RBM5 RBM34	1.50e-03	230	68	5	PS50102
Domain	CH	EHBP1 SYNE1 LRCH3	1.72e-03	65	68	3	SM00033
Domain	-	SETD1A RBM10 RBM26 RBM5 RBM34	1.95e-03	244	68	5	3.30.70.330
Domain	CH	EHBP1 SYNE1 LRCH3	2.12e-03	70	68	3	PF00307
Domain	-	EHBP1 SYNE1 LRCH3	2.21e-03	71	68	3	1.10.418.10
Domain	CH	EHBP1 SYNE1 LRCH3	2.39e-03	73	68	3	PS50021
Domain	Nucleotide-bd_a/b_plait	SETD1A RBM10 RBM26 RBM5 RBM34	2.48e-03	258	68	5	IPR012677
Domain	CH-domain	EHBP1 SYNE1 LRCH3	2.58e-03	75	68	3	IPR001715
Domain	zf-RanBP	RBM10 RBM5	2.88e-03	22	68	2	PF00641
Domain	G_patch	RBM10 RBM5	3.15e-03	23	68	2	SM00443
Domain	G_patch_dom	RBM10 RBM5	3.15e-03	23	68	2	IPR000467
Domain	ZnF_RBZ	RBM10 RBM5	3.15e-03	23	68	2	SM00547
Domain	G_PATCH	RBM10 RBM5	3.15e-03	23	68	2	PS50174
Domain	ZF_RANBP2_2	RBM10 RBM5	3.15e-03	23	68	2	PS50199
Domain	G-patch	RBM10 RBM5	3.15e-03	23	68	2	PF01585
Domain	ZF_RANBP2_1	RBM10 RBM5	3.42e-03	24	68	2	PS01358
Domain	P-loop_NTPase	BLM ABCF1 EP400 N4BP2 MYO18B DNA2 DNAH5 DHX29 SMC1B	3.50e-03	848	68	9	IPR027417
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ERICH1 TUT4 EP400 N4BP2 RBM26 XRN1 APC RBM5 SRGAP2 DNAJA1 JMJD1C GOLGA4 TFRC	3.30e-09	733	72	13	34672954
Pubmed	Human transcription factor protein interaction networks.	BLM SETD1A RIF1 TAF3 NOP14 EP400 ADRM1 TNPO2 RBM10 CFDP1 XRN1 MRPS11 YY1AP1 DNAJA1 JMJD1C RBM34 TFRC	3.93e-09	1429	72	17	35140242
Pubmed	Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.	SRGAP2C SRGAP2 SRGAP2B	8.51e-09	3	72	3	22559944
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	BLM SETD1A ABCF1 EP400 SND1 RBM10 APC LMTK2 DHX29 LRCH3	2.53e-08	440	72	10	34244565
Pubmed	Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication.	SRGAP2C SRGAP2 SRGAP2B	3.40e-08	4	72	3	22559943
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	BLM ABCF1 NOP14 SND1 SACS N4BP2 SYNE1 NECTIN2 MRPS11 EMC10 DNA2 DNAJA1 DHX29 GOLGA4 RBM34 TFRC	4.92e-08	1487	72	16	33957083
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	BLM POLR1F RIF1 ABCF1 NOP14 EP400 COPZ1 SND1 SYNE1 RBM26 XRN1 APC RBM5 SRGAP2 DHX29 LRCH3	5.39e-08	1497	72	16	31527615
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	ABCF1 SND1 RBM10 RBM26 XRN1 APC JMJD1C TFRC	6.16e-08	256	72	8	33397691
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	BLM TAF3 ABCF1 NOP14 EP400 SACS SYNE1 RBM10 MRPS11 APC RBM5 EDIL3 DNAJA1	3.08e-07	1082	72	13	38697112
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	EHBP1 RIF1 ABCF1 EP400 SND1 RBM10 CFDP1 RBM26 XRN1 SRGAP2 DHX29 UBFD1	4.59e-07	934	72	12	33916271
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	SETD1A RIF1 NOP14 EP400 RBM10 RBM26 YY1AP1 JMJD1C	5.46e-07	341	72	8	32971831
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	BLM POLR1F SETD1A RIF1 ABCF1 NOP14 EP400 SND1 XRN1 DNAJA1 DHX29 GOLGA4 RBM34 TFRC	6.15e-07	1353	72	14	29467282
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	TUT4 ABCF1 NOP14 SND1 SYNE1 RBM26 XRN1 MRPS11 RBM5 DHX29 RBM34	8.18e-07	807	72	11	22681889
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	BLM POLR1F RIF1 NOP14 SND1 RBM10 RBM26 MRPS11 RBM5 DNAJA1 JMJD1C TFRC	8.37e-07	989	72	12	36424410
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	BLM POLR1F RIF1 TAF3 EP400 SND1 ADRM1 CFDP1 RBM26 DNAJA1 UBFD1 TFRC	1.09e-06	1014	72	12	32416067
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	BLM SETD1A RIF1 EP400 TNPO2 RBM10 RBM26 DNAJA1	1.61e-06	394	72	8	27248496
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	EHBP1 SND1 NECTIN2 XRN1 APC DNAJA1 DHX29 JMJD1C GOLGA4 TFRC	1.97e-06	708	72	10	39231216
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	BLM RIF1 EP400 RBM10 CFDP1 RBM26 JMJD1C	2.06e-06	283	72	7	30585729
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	BLM POLR1F RIF1 ABCF1 NOP14 SND1 XRN1 DNAJA1 DHX29 RBM34	3.66e-06	759	72	10	35915203
Pubmed	RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5.	RBM10 RBM5	4.23e-06	2	72	2	28662214
Pubmed	The human-specific paralogs SRGAP2B and SRGAP2C differentially modulate SRGAP2A-dependent synaptic development.	SRGAP2C SRGAP2B	4.23e-06	2	72	2	31822692
Pubmed	SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses.	SRGAP2C SRGAP2	4.23e-06	2	72	2	27373832
Pubmed	Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay.	RBM10 RBM5	4.23e-06	2	72	2	28586478
Pubmed	Cancer predisposition caused by elevated mitotic recombination in Bloom mice.	BLM APC	4.23e-06	2	72	2	11101838
Pubmed	Enhanced tumor formation in mice heterozygous for Blm mutation.	BLM APC	4.23e-06	2	72	2	12242442
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BLM RIF1 TLK1 TAF3 ABCF1 EP400 RBM10 YY1AP1 DHX29 GOLGA4	4.35e-06	774	72	10	15302935
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	BLM ERICH1 RIF1 EP400 COPZ1 NECTIN2 XRN1 APC RBM5 GOLGA4	4.50e-06	777	72	10	35844135
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	BLM SETD1A RIF1 TLK1 EP400 RBM10 RBM5 JMJD1C	4.50e-06	453	72	8	29656893
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	RIF1 ABCF1 SND1 SYNE1 RBM26 RBM5 MYO18B DNAJA1 DNAH5 DHX29 GOLGA4 RBM34 TFRC	6.47e-06	1425	72	13	30948266
Pubmed	A human MAP kinase interactome.	EHBP1 RIF1 TLK1 EXPH5 N4BP2 SYNE1 APC YY1AP1	7.51e-06	486	72	8	20936779
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	SETD1A EP400 RBM10 CFDP1 JMJD1C	8.96e-06	134	72	5	25452129
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	POLR1F EHBP1 EXPH5 N4BP2 NECTIN2 XRN1 APC LMTK2 SRGAP2 GOLGA4	1.10e-05	861	72	10	36931259
Pubmed	Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases.	BLM DNA2	1.27e-05	3	72	2	27612385
Pubmed	Co- and post-transcriptional regulation of Rbm5 and Rbm10 in mouse cells as evidenced by tissue-specific, developmental and disease-associated variation of splice variant and protein expression levels.	RBM10 RBM5	1.27e-05	3	72	2	26784654
Pubmed	DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells.	BLM DNA2	1.27e-05	3	72	2	25122754
Pubmed	Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium.	APC EDIL3	1.27e-05	3	72	2	19690388
Pubmed	Clinical and genetic findings in an Ashkenazi Jewish population with colorectal neoplasms.	BLM APC	1.27e-05	3	72	2	15959913
Pubmed	Fine-tuning and autoregulation of the intestinal determinant and tumor suppressor homeobox gene CDX2 by alternative splicing.	APC EDIL3	1.27e-05	3	72	2	28862703
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	RIF1 RBM10 APC DNA2 DNAJA1 DHX29	1.37e-05	250	72	6	33536335
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	BLM EHBP1 RIF1 TLK1 ABCF1 COPZ1 SND1 ADRM1 NECTIN2 SRGAP2 RSPH10B LRCH3	1.60e-05	1321	72	12	27173435
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	ABCF1 NOP14 SND1 RBM10 RBM26 MRPS11 DNAJA1 DHX29 RBM34	1.64e-05	713	72	9	29802200
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	ABCF1 COPZ1 SND1 RBM10 RBM26 MRPS11 DNAJA1 DHX29	1.76e-05	547	72	8	37267103
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SETD1A TAF3 EP400 SND1 RBM10 RBM26 XRN1 JMJD1C	1.81e-05	549	72	8	38280479
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	EHBP1 EXPH5 RBM10 XRN1 APC JMJD1C	1.82e-05	263	72	6	34702444
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	EHBP1 PTPRJ SND1 NECTIN2 XRN1 SRGAP2 DHX29 UBFD1	2.22e-05	565	72	8	25468996
Pubmed	Cereblon Regulates the Proteotoxicity of Tau by Tuning the Chaperone Activity of DNAJA1.	DNAJA1 CRBN	2.53e-05	4	72	2	33972400
Pubmed	A type I DnaJ homolog, DjA1, regulates androgen receptor signaling and spermatogenesis.	NECTIN2 DNAJA1	2.53e-05	4	72	2	15660130
Pubmed	RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.	RBM10 RBM5	2.53e-05	4	72	2	24332178
Pubmed	RPA Phosphorylation Inhibits DNA Resection.	BLM DNA2	2.53e-05	4	72	2	31153714
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	ABCF1 NOP14 COPZ1 SND1 ADRM1 RBM10 RBM26 DNAJA1 DHX29 RBM34	3.08e-05	971	72	10	33306668
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	BLM ERICH1 RIF1 TAF3 NOP14 CFDP1 JMJD1C RBM34	3.73e-05	608	72	8	36089195
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	TLK1 NOP14 SND1 SACS PCDHGA10 N4BP2 SYNE1 XRN1 RBM5 OTUD3 DNAJA1 TFRC	3.78e-05	1442	72	12	35575683
Pubmed	ATRX proximal protein associations boast roles beyond histone deposition.	BLM NOP14 TNPO2 CFDP1	3.94e-05	91	72	4	34780483
Pubmed	Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication.	BLM RIF1	4.21e-05	5	72	2	20711169
Pubmed	Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells.	EDIL3 DNAH5	4.21e-05	5	72	2	25712475
Pubmed	Neuropilin-1 expression in cancer and development.	LYVE1 APC	4.21e-05	5	72	2	22025255
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	RIF1 ABCF1 EP400 SND1 SACS SYNE1 RBM10 EDIL3 DNAJA1 TFRC	4.81e-05	1024	72	10	24711643
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	BLM RIF1 EP400 COPZ1 NECTIN2 GOLGA4 TFRC	5.59e-05	472	72	7	38943005
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	BLM RIF1 ABCF1 NOP14 SND1 XRN1 DNAJA1 RBM34	6.16e-05	653	72	8	22586326
Pubmed	BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.	BLM DNA2	6.31e-05	6	72	2	21325134
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	RIF1 TUT4 SND1 DNAJA1 JMJD1C	6.57e-05	203	72	5	22083510
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	EHBP1 TLK1 SACS EXPH5 N4BP2 GNPTAB JMJD1C	7.33e-05	493	72	7	15368895
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	BLM SETD1A SND1 ADRM1 DNAJA1 CRBN TFRC	7.43e-05	494	72	7	26831064
Pubmed	Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families.	EHBP1 PTPRJ SYNE1 NECTIN2 GOLGA4 TFRC	7.46e-05	339	72	6	37232246
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	BLM RBM10 RBM26 XRN1 DNA2 TFRC	7.58e-05	340	72	6	24332808
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	ABCF1 ADRM1 MYO18B DNAJA1 DHX29 RBM34 LRCH3	7.62e-05	496	72	7	31343991
Pubmed	Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men.	EHBP1 LMTK2	8.82e-05	7	72	2	19866473
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	TLK1 ABCF1 NOP14 EP400 SND1 TNPO2 RBM10 RBM26 RBM5 JMJD1C	8.91e-05	1103	72	10	34189442
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	ZNF544 SYNE1 APC GOLGA4	1.16e-04	120	72	4	31413325
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	EHBP1 TUT4 ABCF1 ADRM1 XRN1 APC LMTK2 EMC10 DNAJA1 DHX29	1.16e-04	1139	72	10	36417873
Pubmed	Individual and cumulative association of prostate cancer susceptibility variants with clinicopathologic characteristics of the disease.	EHBP1 LMTK2	1.17e-04	8	72	2	20450899
Pubmed	DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells.	BLM DNA2	1.17e-04	8	72	2	30464262
Pubmed	Established prostate cancer susceptibility variants are not associated with disease outcome.	EHBP1 LMTK2	1.17e-04	8	72	2	19423541
Pubmed	Prognostic significance of prostate cancer susceptibility variants on prostate-specific antigen recurrence after radical prostatectomy.	EHBP1 LMTK2	1.17e-04	8	72	2	19900942
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	EHBP1 NOP14 ADRM1 SYNE1 NECTIN2 APC EDIL3 GOLGA4	1.20e-04	719	72	8	35337019
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	ABCF1 COPZ1 SND1 ADRM1 TNPO2 RBM10 RBM26 SRGAP2 DNAJA1 TFRC	1.25e-04	1149	72	10	35446349
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	POLR1F TUT4 SND1 XRN1 APC SRGAP2 DNAJA1 DHX29	1.26e-04	724	72	8	36232890
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	RIF1 ABCF1 SND1 N4BP2 RBM10 RBM5 RBM34	1.46e-04	551	72	7	34728620
Pubmed	Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.	EHBP1 LMTK2	1.51e-04	9	72	2	19318432
Pubmed	A dicer-independent miRNA biogenesis pathway that requires Ago catalysis.	EDIL3 TFRC	1.51e-04	9	72	2	20424607
Pubmed	A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis.	APC IL18R1	1.51e-04	9	72	2	25362351
Pubmed	The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling.	APC CRBN	1.51e-04	9	72	2	34489457
Pubmed	Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within interleukin-6 family cytokines.	APC EDIL3	1.51e-04	9	72	2	39128004
Pubmed	Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.	SETD1A SACS GOLGA4	1.55e-04	50	72	3	37974198
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	EP400 TNPO2 APC YY1AP1 DNAJA1 JMJD1C	1.79e-04	398	72	6	35016035
Pubmed	A balance between elongation and trimming regulates telomere stability in stem cells.	BLM DNA2	1.88e-04	10	72	2	27918544
Pubmed	Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair.	BLM RIF1	1.88e-04	10	72	2	23509288
Pubmed	Harnessing host enhancers of SARS-CoV-2 entry as novel targets for antiviral therapy.	PTPRJ NECTIN2 TFRC	2.07e-04	55	72	3	38945485
Pubmed	rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions.	ADRM1 RBM10 RBM5 RBM34	2.21e-04	142	72	4	30217970
Pubmed	Prostate cancer risk associated loci in African Americans.	EHBP1 LMTK2	2.30e-04	11	72	2	19549807
Pubmed	The Ets2 Repressor Factor (Erf) Is Required for Effective Primitive and Definitive Hematopoiesis.	LYVE1 TFRC	2.30e-04	11	72	2	28694332
Pubmed	Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans.	EHBP1 LMTK2	2.30e-04	11	72	2	19902474
Pubmed	Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.	APC IL18R1	2.30e-04	11	72	2	23034650
Pubmed	Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer.	EHBP1 LMTK2	2.30e-04	11	72	2	20878950
Pubmed	An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders.	RGN RBM10	2.30e-04	11	72	2	11944989
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	EHBP1 TLK1 TUT4 PTPRJ ZNF544 NECTIN2 RBM5 SRGAP2 JMJD1C GOLGA4 LRCH3	2.34e-04	1489	72	11	28611215
Pubmed	Deletion of the Syncytin A receptor Ly6e impairs syncytiotrophoblast fusion and placental morphogenesis causing embryonic lethality in mice.	LYVE1 EDIL3	2.75e-04	12	72	2	29500366
Pubmed	Susceptibility loci associated with prostate cancer progression and mortality.	EHBP1 LMTK2	2.75e-04	12	72	2	20460480
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	SYNE1 GNPTAB SRGAP2 GOLGA4	2.79e-04	151	72	4	17043677
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ABCF1 SACS TNPO2 SYNE1 GNPTAB APC YY1AP1 SRGAP2 EDIL3 DNAJA1	3.06e-04	1285	72	10	35914814
Interaction	KCNA3 interactions	EHBP1 CCDC73 SND1 EXPH5 NECTIN2 XRN1 APC DNAJA1 DNAH5 DHX29 JMJD1C GOLGA4 TFRC	9.54e-06	871	71	13	int:KCNA3
Interaction	PHLPP1 interactions	ABCF1 SND1 RBM10 RBM26 XRN1 APC JMJD1C TFRC	2.20e-05	333	71	8	int:PHLPP1
Interaction	COPS5 interactions	BLM EHBP1 TUT4 ABCF1 COPZ1 TNPO2 MYLK4 MRPS11 APC RBM5 DNAJA1 DHX29 CRBN TFRC	2.54e-05	1102	71	14	int:COPS5
Interaction	ATG16L1 interactions	POLR1F SND1 ADRM1 N4BP2 TNPO2 RBM10 NECTIN2 RBM26 APC LMTK2 SRGAP2 DNAJA1 LRCH3 TFRC	4.50e-05	1161	71	14	int:ATG16L1
Interaction	NUP43 interactions	BLM SETD1A RIF1 TAF3 NOP14 EP400 SND1 RBM26 APC JMJD1C	6.43e-05	625	71	10	int:NUP43
Interaction	SIRT6 interactions	BLM SETD1A ABCF1 EP400 SND1 RBM10 APC LMTK2 DHX29 LRCH3	6.70e-05	628	71	10	int:SIRT6
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	SRGAP2C SRGAP2 SRGAP2B	1.72e-05	23	40	3	1288
GeneFamily	RNA binding motif containing	SETD1A RBM10 RBM26 RBM5 RBM34	1.02e-04	213	40	5	725
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	SACS RBM26 APC LMTK2	6.70e-04	181	40	4	694
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	RBM10 RBM5	9.76e-04	21	40	2	89
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	RBM10 RBM5	1.07e-03	22	40	2	579
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	SACS DNAJA1	5.26e-03	49	40	2	584
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	PTPRJ NECTIN2 IL18R1 TFRC	1.09e-02	394	40	4	471
Coexpression	HAMAI_APOPTOSIS_VIA_TRAIL_UP	BLM RIF1 TUT4 SACS GNPTAB RBM26 APC DNAJA1 DHX29 GOLGA4	1.05e-05	656	71	10	M18979
Coexpression	RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP	POLR1F RIF1 TLK1 ADRM1 XRN1 APC SRGAP2 SRGAP2B RBM34 TFRC	2.37e-05	721	71	10	M10237
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#5_top-relative-expression-ranked_1000	RIF1 TLK1 TUT4 ABCF1 APC RBM5 SRGAP2 GOLGA4 TFRC	1.67e-06	339	70	9	gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_1000_k5
CoexpressionAtlas	facebase_RNAseq_e10.5_MandArch_2500_K1	BLM POLR1F RIF1 TUT4 ABCF1 ADRM1 GNPTAB RBM26 APC DNA2 DNAJA1 IL18R1 RBM34 LRCH3	4.47e-05	1241	70	14	facebase_RNAseq_e10.5_MandArch_2500_K1
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_top-relative-expression-ranked_1000	RIF1 RGN TLK1 TUT4 ABCF1 APC RBM5 SRGAP2 DNA2 GOLGA4 TFRC	5.83e-05	801	70	11	gudmap_developingKidney_e15.5_ureter tip_1000_flank cortic collct
CoexpressionAtlas	DevelopingKidney_e15.5_Cap mesenchyme_emap-27738_k-means-cluster#5_top-relative-expression-ranked_1000	RIF1 TUT4 APC UBFD1 TFRC	1.21e-04	146	70	5	gudmap_developingKidney_e15.5_Cap mesenchyme_1000_k5
CoexpressionAtlas	facebase_RNAseq_e10.5_MaxArch_2500_K3	BLM POLR1F RIF1 TAF3 TUT4 GNPTAB MYLK4 RBM26 APC DNA2 DNAJA1 IL18R1 LRCH3	2.00e-04	1252	70	13	facebase_RNAseq_e10.5_MaxArch_2500_K3
CoexpressionAtlas	dev gonad_e11.5_M_PrimGermCell_Oct_top-relative-expression-ranked_500	BLM ARL14EPL RIF1 FKBP6 DNA2 SMC1B TFRC	2.37e-04	376	70	7	gudmap_dev gonad_e11.5_M_PrimGermCell_Oct_500
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_top-relative-expression-ranked_500	SETD1A RIF1 FKBP6 SACS RBM26 RBM5 SMC1B	2.61e-04	382	70	7	gudmap_developingGonad_e14.5_ ovary_500
CoexpressionAtlas	facebase_RNAseq_e10.5_MandArch_2500	BLM POLR1F RIF1 TUT4 ABCF1 ADRM1 GNPTAB RBM26 APC DNA2 DNAJA1 IL18R1 RBM34 LRCH3	2.65e-04	1468	70	14	facebase_RNAseq_e10.5_MandArch_2500
CoexpressionAtlas	dev gonad_e11.5_F_PrimGermCell_Oct_top-relative-expression-ranked_500	BLM ARL14EPL RIF1 FKBP6 DNA2 SMC1B TFRC	2.78e-04	386	70	7	gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_500
CoexpressionAtlas	DevelopingGonad_e18.5_ovary_emap-12283_top-relative-expression-ranked_500	SETD1A RIF1 FKBP6 CCDC73 RBM26 RBM5 SMC1B	2.83e-04	387	70	7	gudmap_developingGonad_e18.5_ovary_500
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_top-relative-expression-ranked_500	BLM ARL14EPL RIF1 FKBP6 DNA2 SMC1B TFRC	2.83e-04	387	70	7	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_500
CoexpressionAtlas	dev gonad_e12.5_F_GermCellOvary_Oct_top-relative-expression-ranked_500	BLM ARL14EPL RIF1 FKBP6 DNA2 SMC1B TFRC	3.77e-04	406	70	7	gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_500
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_k-means-cluster#1_top-relative-expression-ranked_500	BLM RIF1 FKBP6 TFRC	4.03e-04	105	70	4	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_k1_500
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cyth3_(Cyth3)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	PCDHGA10 EXPH5 RBM26 RBM5 RSPH10B	4.96e-06	153	72	5	88ca2d2c2ab19fbee13e18951b993ee05dd30f67
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cyth3_(Cyth3)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	PCDHGA10 EXPH5 RBM26 RBM5 RSPH10B	4.96e-06	153	72	5	553dff9688a1996d8f4ba16e60c683593d781389
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C CCDC73 EXPH5 SRGAP2 SRGAP2B	1.09e-05	180	72	5	d685fa2b013bc085dbef7c40956ed3043f83e483
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C EXPH5 SRGAP2 SRGAP2B EDIL3	1.18e-05	183	72	5	848fc6dd129150897ee339343e83c645b6e779eb
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TUT4 XRN1 APC JMJD1C GOLGA4	1.21e-05	184	72	5	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LYVE1 SRGAP2C SRGAP2 SRGAP2B TFRC	1.42e-05	190	72	5	2d54fca50593fbd11fe13fc2bfaf937a05db776d
ToppCell	LV-08._Macrophage\|World / Chamber and Cluster_Paper	LYVE1 SRGAP2C PTPRJ SRGAP2 SRGAP2B	1.45e-05	191	72	5	e7a0bc46ba9ba772636a583f3387748418e18832
ToppCell	LV-08._Macrophage\|LV / Chamber and Cluster_Paper	LYVE1 SRGAP2C PTPRJ SRGAP2 SRGAP2B	1.49e-05	192	72	5	7be12d580aaf2f2f1562203fcad3a44639b8c5a6
ToppCell	Control-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	BLM SRGAP2C PTPRJ SRGAP2 SRGAP2B	1.53e-05	193	72	5	3479c01aaae7afd7e02d00e0cb21951c0106a0fd
ToppCell	Control-Myeloid-ncMonocyte\|Control / Disease state, Lineage and Cell class	BLM SRGAP2C PTPRJ SRGAP2 SRGAP2B	1.61e-05	195	72	5	fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	TLK1 TAF3 EXPH5 DHX29 GOLGA4	1.73e-05	198	72	5	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	(09)_Interm._secr.>cil.\|World / shred by cell type by condition	RSPH10B2 CCDC74B SYNE1 DNAH5 RSPH10B	1.81e-05	200	72	5	3305e14dba12e94da42f0414fdc7a2c8caf0a183
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_C\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	LYVE1 CCDC73 EDIL3 RTP4	1.19e-04	156	72	4	6c8f442ed94ae31e6832b68137e98ae78091ac6c
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EHBP1 ARL14EPL EXPH5 DNAH5	1.25e-04	158	72	4	f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EHBP1 ARL14EPL EXPH5 DNAH5	1.25e-04	158	72	4	8c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	LYVE1 PTPRJ EMC10 MYO18B	1.66e-04	170	72	4	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	TUT4 SYNE1 JMJD1C TFRC	1.69e-04	171	72	4	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_NK-natural_killer_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SYNE1 GNPTAB IL18R1 RSPH10B	1.73e-04	172	72	4	68fd03f2c8ee01fe46194400f74ede3830e00f34
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BLM GOLGA8S SYNE1 EDIL3	1.73e-04	172	72	4	c056d44e2e130ceccadfcdceb192a7f095d779c8
ToppCell	COVID-19-kidney-Podocyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SRGAP2C EXPH5 SRGAP2 SRGAP2B	1.85e-04	175	72	4	a73e3a65fd5c1e09cb0c2dae20c1a7bfcae49223
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C EXPH5 SRGAP2 SRGAP2B	1.93e-04	177	72	4	4d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C EXPH5 SRGAP2 SRGAP2B	1.98e-04	178	72	4	edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C EXPH5 SRGAP2 SRGAP2B	2.02e-04	179	72	4	7394e77e665bf16d3733df91bb12907be460ab44
ToppCell	368C-Epithelial_cells-Epithelial-F_(Ciliated)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	RSPH10B2 CCDC74B DNAH5 C1orf141	2.11e-04	181	72	4	5a4574f1bfd0b4ca78da7effda43420857e17296
ToppCell	368C-Epithelial_cells-Epithelial-F_(Ciliated)\|368C / Donor, Lineage, Cell class and subclass (all cells)	RSPH10B2 CCDC74B DNAH5 C1orf141	2.11e-04	181	72	4	a4e891603645f694687e68e585744ddc1a3c8697
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C EXPH5 SRGAP2 SRGAP2B	2.11e-04	181	72	4	5bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCell	COPD-Myeloid-DC_Mature\|World / Disease state, Lineage and Cell class	SRGAP2C NECTIN2 SRGAP2 SRGAP2B	2.11e-04	181	72	4	675603a401d92cf9fdcd44e211ec899fa86a0d49
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	SRGAP2B JMJD1C RBM34 TFRC	2.11e-04	181	72	4	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C EXPH5 SRGAP2 SRGAP2B	2.11e-04	181	72	4	8e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCell	COVID-19-kidney-Podocyte\|kidney / Disease (COVID-19 only), tissue and cell type	SRGAP2C EXPH5 SRGAP2 SRGAP2B	2.20e-04	183	72	4	fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C EXPH5 SRGAP2 SRGAP2B	2.20e-04	183	72	4	3c516fe5083f02bad1f464ed284010b4131a833c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C EXPH5 SRGAP2 SRGAP2B	2.20e-04	183	72	4	7c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C EXPH5 SRGAP2 SRGAP2B	2.20e-04	183	72	4	612d93df03252d4d2ccdce5a9bc162cfd9172a1a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C EXPH5 SRGAP2 SRGAP2B	2.20e-04	183	72	4	eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C EXPH5 SRGAP2 SRGAP2B	2.20e-04	183	72	4	9c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C EXPH5 SRGAP2 SRGAP2B	2.24e-04	184	72	4	7294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C EXPH5 SRGAP2 SRGAP2B	2.29e-04	185	72	4	b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C EXPH5 SRGAP2 SRGAP2B	2.29e-04	185	72	4	9197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C EXPH5 SRGAP2 SRGAP2B	2.29e-04	185	72	4	ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C EXPH5 SRGAP2 SRGAP2B	2.38e-04	187	72	4	24c2a3962da364e46e98abeab5f8234376fa26bb
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C EXPH5 SRGAP2 SRGAP2B	2.43e-04	188	72	4	047c4e0b03fc8334e38c48977e41d26dbe229d47
ToppCell	Control-Myeloid-cDC2\|Control / Disease state, Lineage and Cell class	SRGAP2C SRGAP2 SRGAP2B IL18R1	2.53e-04	190	72	4	4e481e42353d47af7991744000403af2873f6a41
ToppCell	Control-Myeloid-cDC2\|World / Disease state, Lineage and Cell class	SRGAP2C SRGAP2 SRGAP2B IL18R1	2.58e-04	191	72	4	11dfd8f38beb294f42710cfbd355cb089e1023c0
ToppCell	droplet-Heart-nan-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EHBP1 MYLK4 MYO18B TFRC	2.58e-04	191	72	4	97fb4232417a39801e87725755fd16a57c250209
ToppCell	COPD-Myeloid-cDC2\|World / Disease state, Lineage and Cell class	SRGAP2C SRGAP2 SRGAP2B IL18R1	2.58e-04	191	72	4	4e4887175200a57e1b041f2f131e3df774df3509
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	GNPTAB DNA2 IL18R1 TFRC	2.58e-04	191	72	4	9454f642c3621370fa23640b631301346b300950
ToppCell	COPD-Myeloid-cDC2\|COPD / Disease state, Lineage and Cell class	SRGAP2C SRGAP2 SRGAP2B IL18R1	2.58e-04	191	72	4	2af6e4a6bd1f2193ece2131c3b7d976dd23a6966
ToppCell	droplet-Heart-nan-3m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EHBP1 MYLK4 MYO18B TFRC	2.58e-04	191	72	4	64070a309d7e3f6001272409ab9ce206d0e7d73f
ToppCell	COPD-Myeloid-cDC2\|Myeloid / Disease state, Lineage and Cell class	SRGAP2C SRGAP2 SRGAP2B IL18R1	2.64e-04	192	72	4	984cdc2f1d93e164bc946d63f58dacb629f82eb7
ToppCell	RV-08._Macrophage\|World / Chamber and Cluster_Paper	LYVE1 PTPRJ SRGAP2 SRGAP2B	2.64e-04	192	72	4	a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCell	BAL-Mild\|BAL / Compartment, Disease Groups and Clusters	SRGAP2C XRN1 SRGAP2 RTP4	2.64e-04	192	72	4	1a6cbf014d3f7a3fb6f53adab078c4742e7137de
ToppCell	control-Lymphoid-CTL\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PTPRJ SYNE1 GNPTAB XRN1	2.69e-04	193	72	4	89d407a88b5956559a589425b89b3eb8dc78e1dd
ToppCell	Control-Myeloid-cDC2\|Myeloid / Disease state, Lineage and Cell class	SRGAP2C SRGAP2 SRGAP2B IL18R1	2.69e-04	193	72	4	4cb938c346cc32ec122d11e6b9f25db20e0f7ff6
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2C EXPH5 SRGAP2 SRGAP2B	2.69e-04	193	72	4	3eaa0461618582a1754400624350d269d24e750a
ToppCell	RV-08._Macrophage\|RV / Chamber and Cluster_Paper	LYVE1 PTPRJ SRGAP2 SRGAP2B	2.69e-04	193	72	4	12bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCell	COVID-19_Mild-PLT_4\|World / Disease Group and Platelet Clusters	RBM5 DHX29 JMJD1C CRBN	2.69e-04	193	72	4	98a52523aa1efd5d14a2878ed106828a80a33aa2
ToppCell	IPF-Myeloid-cDC2\|Myeloid / Disease state, Lineage and Cell class	SRGAP2C SRGAP2 SRGAP2B IL18R1	2.74e-04	194	72	4	accf4b7b09e2048f2e47a52201e0158684dda8fe
ToppCell	COPD-Myeloid-Macrophage\|World / Disease state, Lineage and Cell class	SRGAP2C SRGAP2 SRGAP2B TFRC	2.74e-04	194	72	4	7d682408e9a6239a4e47befc9376e760cc3d133a
ToppCell	LA-08._Macrophage\|World / Chamber and Cluster_Paper	LYVE1 SRGAP2 SRGAP2B TFRC	2.74e-04	194	72	4	c1805572bcc11b1cd29083329d7b5911489fb758
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SRGAP2C NECTIN2 SRGAP2 SRGAP2B	2.80e-04	195	72	4	c9469e2d31beb30ebb64b3f0a5239e23119fbaa5
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Ciliated\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CCDC74B DNAH5 C1orf141 RSPH10B	2.80e-04	195	72	4	cfcf554b436083179dea1d6fd6e3a800ea2430fe
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1D RIF1 XRN1 GOLGA4	2.80e-04	195	72	4	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SRGAP2C NECTIN2 SRGAP2 SRGAP2B	2.80e-04	195	72	4	2f2e29089a8cb748d2c1329c5c8465165b25bc8b
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Myeloid\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LYVE1 SRGAP2C SRGAP2 SRGAP2B	2.80e-04	195	72	4	f289a44010788853d7726d4b5aa75f3c62186c08
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CCDC74B SYNE1 DNAH5 C1orf141	2.91e-04	197	72	4	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	TUT4 XRN1 JMJD1C GOLGA4	2.91e-04	197	72	4	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	Sigmoid-B_cell-B_cell_IgG_Plasma\|B_cell / Region, Cell class and subclass	TLK1 XRN1 DHX29 CRBN	2.96e-04	198	72	4	305d7ae9b070ac7211638a5282374c02bf13af40
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	TUT4 XRN1 JMJD1C GOLGA4	2.96e-04	198	72	4	44417089b62056269cac38d3134ff209c05b7007
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TUT4 XRN1 JMJD1C GOLGA4	2.96e-04	198	72	4	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	LPS_anti-TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ANKRD31 CCDC74B DNAH5 C1orf141	3.02e-04	199	72	4	15f7814b7074170eee7ccacaa670b1d128fc68bb
ToppCell	Hematolymphoid-Microglia\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SRGAP2C PTPRJ SRGAP2 SRGAP2B	3.08e-04	200	72	4	21bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCell	COVID-mono1\|COVID / Condition, Cell_class and T cell subcluster	LYVE1 SRGAP2C SRGAP2 SRGAP2B	3.08e-04	200	72	4	bd002c54305c746c07b7418a2084195e9c852ec5
ToppCell	Hematolymphoid-Microglia-TYROBP----L1-3\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SRGAP2C PTPRJ SRGAP2 SRGAP2B	3.08e-04	200	72	4	a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCell	Hematolymphoid-Microglia-TYROBP--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SRGAP2C PTPRJ SRGAP2 SRGAP2B	3.08e-04	200	72	4	dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCell	Hematolymphoid-Microglia-TYROBP---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SRGAP2C PTPRJ SRGAP2 SRGAP2B	3.08e-04	200	72	4	a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCell	Hematolymphoid-Microglia-TYROBP-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SRGAP2C PTPRJ SRGAP2 SRGAP2B	3.08e-04	200	72	4	3bba5219453322198e8fdb0921d5f8c403598751
ToppCell	Hematolymphoid-Microglia-TYROBP\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SRGAP2C PTPRJ SRGAP2 SRGAP2B	3.08e-04	200	72	4	33036d21c1c82109284473a515c4f890b33fdd5c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ANKRD31 SYNE1 APC CCDC196	3.08e-04	200	72	4	07d942803360e1a1e8e131d6e31c726dd0db1a0b
ToppCell	COVID-mono1-\|COVID / Condition, Cell_class and T cell subcluster	LYVE1 SRGAP2C SRGAP2 SRGAP2B	3.08e-04	200	72	4	445a1aab962673dcc926c33ce9bed5ede9c41c57
ToppCell	mild-gd_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 GNPTAB XRN1 GOLGA4	3.08e-04	200	72	4	109f673a4967ffa52270a0b4f818b3461288db44
Disease	Bloom syndrome (implicated_via_orthology)	BLM DNA2	1.48e-05	3	66	2	DOID:2717 (implicated_via_orthology)
Disease	Werner syndrome (implicated_via_orthology)	BLM DNA2	4.91e-05	5	66	2	DOID:5688 (implicated_via_orthology)
Disease	immature platelet count	TLK1 COPZ1 NECTIN2 JMJD1C	9.55e-05	106	66	4	EFO_0803544
Disease	coffee consumption measurement, tea consumption measurement	PTPRJ XRN1 JMJD1C	1.33e-04	44	66	3	EFO_0006781, EFO_0010091
Disease	free cholesterol in large LDL measurement	ANKRD31 NECTIN2 JMJD1C	2.06e-04	51	66	3	EFO_0022176
Disease	cholesterol to total lipids in small VLDL percentage	ANKRD31 NECTIN2 JMJD1C	2.06e-04	51	66	3	EFO_0022242
Disease	susceptibility to bacterial meningitis measurement	CACNA1D DNAH5 CRBN	2.18e-04	52	66	3	EFO_0008411
Disease	triglycerides to total lipids in very large VLDL percentage	ANKRD31 NECTIN2 JMJD1C	2.31e-04	53	66	3	EFO_0022340
Disease	free cholesterol to total lipids in medium VLDL percentage	ANKRD31 NECTIN2 JMJD1C	2.87e-04	57	66	3	EFO_0022284
Disease	triglycerides to total lipids in small VLDL percentage	ANKRD31 NECTIN2 JMJD1C	3.02e-04	58	66	3	EFO_0022338
Disease	cholesterol in IDL measurement	ANKRD31 NECTIN2 JMJD1C	3.02e-04	58	66	3	EFO_0021899
Disease	free cholesterol to total lipids in very large VLDL percentage	ANKRD31 NECTIN2 JMJD1C	3.18e-04	59	66	3	EFO_0022289
Disease	C-C motif chemokine 28 measurement	COPZ1 JMJD1C	3.21e-04	12	66	2	EFO_0020199
Disease	total lipids in IDL	ANKRD31 NECTIN2 JMJD1C	3.34e-04	60	66	3	EFO_0022161
Disease	free cholesterol in IDL measurement	ANKRD31 NECTIN2 JMJD1C	3.51e-04	61	66	3	EFO_0022181
Disease	triglycerides to total lipids in medium VLDL percentage	ANKRD31 NECTIN2 JMJD1C	3.86e-04	63	66	3	EFO_0022335
Disease	cholesterol to total lipids in medium VLDL percentage	ANKRD31 NECTIN2 JMJD1C	3.86e-04	63	66	3	EFO_0022239
Disease	interleukin 18 receptor 1 measurement	IL18R1 C1orf141	5.08e-04	15	66	2	EFO_0008178
Disease	shigellosis	MYLK4 C1orf141	5.79e-04	16	66	2	EFO_0005585
Disease	free cholesterol to total lipids in small VLDL percentage	ANKRD31 NECTIN2 JMJD1C	6.43e-04	75	66	3	EFO_0022287
Disease	chronic obstructive pulmonary disease	EHBP1 CACNA1D SETD1A CFDP1 SRGAP2 DNAH5 IL18R1	8.59e-04	688	66	7	EFO_0000341
Disease	ulcerative colitis, Crohn's disease	OTUD3 C1orf141	9.12e-04	20	66	2	EFO_0000384, EFO_0000729
Disease	trans fatty acid measurement, trans/trans-18:2 fatty acid measurement	CACNA1D MYO18B	1.32e-03	24	66	2	EFO_0006821, EFO_0006826
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	PTPRJ APC	1.55e-03	26	66	2	C0009405
Disease	Colorectal cancer	PTPRJ APC	1.67e-03	27	66	2	cv:C0346629
Disease	COLORECTAL CANCER	PTPRJ APC	1.67e-03	27	66	2	114500
Disease	Neoplasm of the large intestine	PTPRJ APC	1.67e-03	27	66	2	cv:C0009404
Disease	hypertension, COVID-19	CACNA1D PTPRJ	1.67e-03	27	66	2	EFO_0000537, MONDO_0100096
Disease	remnant cholesterol measurement	EHBP1 ANKRD31 NECTIN2	1.85e-03	108	66	3	EFO_0010815
Disease	Hereditary Nonpolyposis Colorectal Cancer	PTPRJ APC	1.92e-03	29	66	2	C1333990

Protein segments in the cluster

Peptide	Gene	Start	Entry
KKFKNPNNVLIEQAE	ERICH1	121	Q86X53
KKALADQQKAQQPAV	EP400	2526	Q96L91
VADFNPETRQQKKKA	ARL14EPL	51	P0DKL9
KAKPQNKFAALDNEE	ABCF1	186	Q8NE71
KSPQMNDFNIKENKS	C1orf141	141	Q5JVX7
QDSKEAKKPNIINFD	CRBN	36	Q96SW2
EQAATFKLEKNKQGQ	DHX29	276	Q7Z478
DKNPNEGEKFKQISQ	DNAJA1	36	P31689
FNKQDSKADVPQKAD	CCDC74B	191	Q96LY2
ALKQTPKNNFAERQK	CCDC74B	351	Q96LY2
SLNKQKENFKNSFQP	RBM10	661	P98175
FQKKVQFGNENTKLE	RBM26	521	Q5T8P6
RSVNKEKFKQQNSNP	RBM34	361	P42696
EKFKQQNSNPRLKNV	RBM34	366	P42696
AEPQNSFKELNNENK	GOLGA8S	361	H3BPF8
NPNQKDQKQKSALDE	ANKRD31	1246	Q8N7Z5
KPKKDRQNVQQNEDA	RSPH10B	56	P0C881
KPKKDRQNVQQNEDA	RSPH10B2	56	B2RC85
KDAKNNEVSFSQIKP	PTPRJ	1001	Q12913
NKNPTIKKNAEFEDQ	IL18R1	166	Q13478
LDFVKQKASQSPQKQ	LRCH3	506	Q96II8
KKANQQLNFTEAKEA	LYVE1	46	Q9Y5Y7
LNNPKDFQELNKQTK	GNPTAB	271	Q3T906
KKYQQKLEQEENPGN	GOLGA4	2086	Q13439
NSSEQKPENELKNKN	JMJD1C	391	Q15652
NDNAPKFQAENLDVK	PCDHGA10	131	Q9Y5H3
PSVKEQKAFEKNIFN	COPZ1	36	P61923
NAQKKKNRGSDAQDF	MYLK4	371	Q86YV6
REEKDNAGKNQKNQF	EXPH5	921	Q8NEV8
KASANPKEQDTFLKN	LMTK2	171	Q8IWU2
KANSNPFEVKVNRQK	NOP14	26	P78316
LNKQKENFKNSFQPV	RBM5	551	P52756
NKAQASPSEENKANK	OTUD3	321	Q5T2D3
SPSEENKANKNQLAK	OTUD3	326	Q5T2D3
QASPVAFKKINNNDD	NPY1R	366	P25929
KEQPFNHDINNELKK	FKBP6	281	O75344
KQRKDKVFQGNFDND	EDIL3	426	O43854
SFFKQNEKEKPQANV	CFDP1	191	Q9UEE9
TNQQRVKDFFKNAPA	BLM	81	P54132
ENKEKNPIKENFPFN	CCDC125	441	Q86Z20
DKKFQNVPEVNNENS	CCDC73	391	Q6ZRK6
KNKVKNQIYPEADFA	CCDC144B	581	Q3MJ40
NPQDIKENNKKAYDG	EHBP1	496	Q8NDI1
FNQNKTTDPKEEIKQ	LAS2	311	Q8IYD9
DQQKAPQTKNKADLQ	CCDC196	126	A0A1B0GTZ2
QKAKNPQEQKSFFAK	EMC10	211	Q5UCC4
FQKAINNSFAPEKLQ	DNA2	166	P51530
KFNGAQVNPKFKQCD	SACS	3681	Q9NZJ4
KKNNKPEVNQIANSD	CACNA1D	786	Q01668
QKLKQNPNAKQFDFS	DNAH5	451	Q8TE73
ANQAKNQSAEAKEAK	RTP4	196	Q96DX8
LNSENQPKKAVVADK	TAF3	371	Q5VWG9
KAKQIAQKDVAFAPE	SYNE1	2041	Q8NF91
NAETEQNKKKADPEN	RIF1	1496	Q5UIP0
APTANLDQKDKQFVA	SND1	331	Q7KZF4
TKDQQFKKDQNVLSP	SRGAP2C	81	P0DJJ0
TKDQQFKKDQNVLSP	SRGAP2B	81	P0DMP2
DKKNNRFNDGKVDPA	RGN	96	Q15493
ENADNNTKANVTKPK	TFRC	46	P02786
EEKAKPFQNAAKQQA	SETD1A	831	O15047
PFQNAAKQQAKEEDK	SETD1A	836	O15047
AFAKAMQNNAKPEQK	ADRM1	376	Q16186
LKNNSKVFNDKLPNN	APC	1816	P25054
NPNIKDSKDNQAKQN	APC	2691	P25054
PKQRKNKAVNGAEND	TLK1	366	Q9UKI8
QDAAAKQKVEQNAAP	MRPS11	41	P82912
PKDAAQQDAKAEENK	UBFD1	166	O14562
AAVAFKNAKQFEQAK	NAPG	41	Q99747
DAQFNFNKKKNIAAE	SMC1B	181	Q8NDV3
VQDKLKQLNQFPDFN	TNPO2	31	O14787
TKDQQFKKDQNVLSP	SRGAP2	81	O75044
RVANKKNFENKEAQS	XRN1	1611	Q8IZH2
KKKHQEVQDQDPVFQ	POLR1F	281	Q3B726
SKPEDKQKAAAAFAQ	MYO18B	791	Q8IUG5
NPQDKILFTKAEDNK	YY1AP1	296	Q9H869
KPNSQVKELKQNSAF	ZNF544	186	Q6NX49
NSIAEENKAKADQPK	TUT4	581	Q5TAX3
QKVSPQQEKHKQNFA	PIFO	96	Q8TCI5
NQNRAKEAFEKKISP	N4BP2	496	Q86UW6
KPKNQAEAQKVTFSQ	NECTIN2	161	Q92692