Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionarachidonate-CoA ligase activity

ACSL6 ACSL5

1.53e-0411342GO:0047676
GeneOntologyMolecularFunctionlong-chain fatty acid-CoA ligase activity

ACSL6 ACSL5

2.91e-0415342GO:0004467
GeneOntologyMolecularFunctionprotein serine kinase activity

OBSCN STK39 OXSR1 RPS6KA5 MAP3K4

3.48e-04363345GO:0106310
GeneOntologyMolecularFunctioncargo receptor activity

SSC5D APOBR CD163

4.05e-0485343GO:0038024
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

OBSCN STK39 OXSR1 RPS6KA5 MAP3K4

8.86e-04446345GO:0004674
GeneOntologyMolecularFunctionfatty acid ligase activity

ACSL6 ACSL5

8.91e-0426342GO:0015645
GeneOntologyMolecularFunctionCoA-ligase activity

ACSL6 ACSL5

9.62e-0427342GO:0016405
GeneOntologyMolecularFunctionscavenger receptor activity

SSC5D CD163

9.62e-0427342GO:0005044
GeneOntologyMolecularFunctionGTPase activator activity

SRGAP2 SRGAP1 RAB3GAP2 TBC1D9

1.24e-03279344GO:0005096
GeneOntologyMolecularFunctionacid-thiol ligase activity

ACSL6 ACSL5

1.27e-0331342GO:0016878
GeneOntologyMolecularFunctionGTPase regulator activity

OBSCN SRGAP2 SRGAP1 RAB3GAP2 TBC1D9

1.57e-03507345GO:0030695
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

OBSCN SRGAP2 SRGAP1 RAB3GAP2 TBC1D9

1.57e-03507345GO:0060589
GeneOntologyMolecularFunctioncarbohydrate binding

ATRN MRC2 FBXO2 CEMIP

1.83e-03310344GO:0030246
GeneOntologyMolecularFunctionligase activity, forming carbon-sulfur bonds

ACSL6 ACSL5

2.21e-0341342GO:0016877
GeneOntologyMolecularFunctionGTPase binding

AMBRA1 SRGAP2 SRGAP1 RAB3GAP2

3.14e-03360344GO:0051020
GeneOntologyMolecularFunctionprotein kinase activity

OBSCN STK39 OXSR1 RPS6KA5 MAP3K4

3.26e-03600345GO:0004672
GeneOntologyMolecularFunctionalpha-tubulin binding

DNAI7 TBCE

3.54e-0352342GO:0043014
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

OBSCN STK39 OXSR1 RPS6KA5 MAP3K4

6.59e-03709345GO:0016773
GeneOntologyMolecularFunctionkinase activity

OBSCN STK39 OXSR1 RPS6KA5 MAP3K4

8.97e-03764345GO:0016301
GeneOntologyBiologicalProcesspositive regulation of long-chain fatty acid import across plasma membrane

ACSL6 ACSL5

7.90e-063342GO:0010747
GeneOntologyBiologicalProcesspositive regulation of long-chain fatty acid import into cell

ACSL6 ACSL5

1.58e-054342GO:0140214
GeneOntologyBiologicalProcessregulation of long-chain fatty acid import across plasma membrane

ACSL6 ACSL5

5.51e-057342GO:0010746
GeneOntologyBiologicalProcesschemokine (C-X-C motif) ligand 12 signaling pathway

STK39 OXSR1

5.51e-057342GO:0038146
GeneOntologyBiologicalProcessregulation of long-chain fatty acid import into cell

ACSL6 ACSL5

9.43e-059342GO:0140212
GeneOntologyBiologicalProcesscellular hypotonic response

STK39 OXSR1

1.72e-0412342GO:0071476
GeneOntologyBiologicalProcesslong-chain fatty acid import across plasma membrane

ACSL6 ACSL5

1.72e-0412342GO:0015911
GeneOntologyBiologicalProcesshypotonic response

STK39 OXSR1

2.37e-0414342GO:0006971
GeneOntologyBiologicalProcessrenal sodium ion absorption

STK39 OXSR1

2.73e-0415342GO:0070294
GeneOntologyBiologicalProcesspositive regulation of T cell chemotaxis

STK39 OXSR1

3.12e-0416342GO:0010820
GeneOntologyBiologicalProcessrenal sodium ion transport

STK39 OXSR1

3.97e-0418342GO:0003096
GeneOntologyBiologicalProcesslong-chain fatty-acyl-CoA biosynthetic process

ACSL6 ACSL5

4.43e-0419342GO:0035338
GeneOntologyBiologicalProcessregulation of T cell chemotaxis

STK39 OXSR1

4.92e-0420342GO:0010819
GeneOntologyBiologicalProcesslong-chain fatty acid import into cell

ACSL6 ACSL5

4.92e-0420342GO:0044539
GeneOntologyBiologicalProcesspositive regulation of lymphocyte chemotaxis

STK39 OXSR1

5.97e-0422342GO:0140131
GeneOntologyBiologicalProcessfatty acid transmembrane transport

ACSL6 ACSL5

5.97e-0422342GO:1902001
GeneOntologyBiologicalProcesslipid import into cell

ACSL6 ACSL5

7.73e-0425342GO:0140354
GeneOntologyBiologicalProcesspeptidyl-threonine phosphorylation

STK39 OXSR1 CEMIP

8.91e-04115343GO:0018107
GeneOntologyBiologicalProcesslong-chain fatty-acyl-CoA metabolic process

ACSL6 ACSL5

9.02e-0427342GO:0035336
GeneOntologyBiologicalProcessfatty-acyl-CoA biosynthetic process

ACSL6 ACSL5

9.02e-0427342GO:0046949
GeneOntologyBiologicalProcesspositive regulation of transmembrane transport

ACSL6 STK39 ACSL5 CEMIP

1.02e-03273344GO:0034764
GeneOntologyBiologicalProcessnegative regulation of potassium ion transmembrane transporter activity

STK39 OXSR1

1.04e-0329342GO:1901017
GeneOntologyBiologicalProcesspositive regulation of fatty acid transport

ACSL6 ACSL5

1.04e-0329342GO:2000193
GeneOntologyBiologicalProcesspeptidyl-threonine modification

STK39 OXSR1 CEMIP

1.13e-03125343GO:0018210
GeneOntologyBiologicalProcesstriglyceride metabolic process

ACSL6 APOBR ACSL5

1.19e-03127343GO:0006641
GeneOntologyBiologicalProcessregulation of lymphocyte chemotaxis

STK39 OXSR1

1.19e-0331342GO:1901623
GeneOntologyBiologicalProcessinflammatory response

ATRN ADGRE5 STK39 CD5L RPS6KA5 CD163 BAP1

1.34e-031043347GO:0006954
GeneOntologyBiologicalProcesscellular hyperosmotic response

STK39 OXSR1

1.35e-0333342GO:0071474
GeneOntologyBiologicalProcessT cell chemotaxis

STK39 OXSR1

1.35e-0333342GO:0010818
GeneOntologyBiologicalProcesspositive regulation of p38MAPK cascade

STK39 MAP3K4

1.52e-0335342GO:1900745
GeneOntologyBiologicalProcessnegative regulation of potassium ion transmembrane transport

STK39 OXSR1

1.52e-0335342GO:1901380
DomainSRCR

SSC5D CD5L CD163

7.17e-0621343PF00530
DomainSR

SSC5D CD5L CD163

1.23e-0525343SM00202
Domain-

SSC5D CD5L CD163

1.23e-05253433.10.250.10
DomainSRCR_1

SSC5D CD5L CD163

1.39e-0526343PS00420
DomainSRCR-like_dom

SSC5D CD5L CD163

1.39e-0526343IPR017448
DomainSRCR_2

SSC5D CD5L CD163

1.39e-0526343PS50287
DomainSRCR

SSC5D CD5L CD163

1.56e-0527343IPR001190
DomainKinase_OSR1/WNK_CCT

STK39 OXSR1

4.80e-056342IPR024678
DomainOSR1_C

STK39 OXSR1

4.80e-056342PF12202
DomainSer/Thr_kinase_AS

OBSCN STK39 OXSR1 RPS6KA5 MAP3K4

4.38e-04357345IPR008271
DomainS_TKc

OBSCN STK39 OXSR1 RPS6KA5 MAP3K4

4.49e-04359345SM00220
DomainPROTEIN_KINASE_ST

OBSCN STK39 OXSR1 RPS6KA5 MAP3K4

4.66e-04362345PS00108
DomainProtein_kinase_ATP_BS

OBSCN STK39 OXSR1 RPS6KA5 MAP3K4

5.74e-04379345IPR017441
DomainPkinase

OBSCN STK39 OXSR1 RPS6KA5 MAP3K4

5.88e-04381345PF00069
DomainSH3

OBSCN SRGAP2 SRGAP1 SH3YL1

6.15e-04216344PS50002
DomainSH3

OBSCN SRGAP2 SRGAP1 SH3YL1

6.15e-04216344SM00326
DomainSH3_domain

OBSCN SRGAP2 SRGAP1 SH3YL1

6.58e-04220344IPR001452
DomainFCH

SRGAP2 SRGAP1

7.26e-0422342PF00611
DomainFCH

SRGAP2 SRGAP1

7.26e-0422342SM00055
DomainFCH_dom

SRGAP2 SRGAP1

7.95e-0423342IPR001060
DomainF_BAR

SRGAP2 SRGAP1

9.40e-0425342IPR031160
DomainF_BAR

SRGAP2 SRGAP1

9.40e-0425342PS51741
DomainAMP-binding_CS

ACSL6 ACSL5

1.02e-0326342IPR020845
DomainAMP_BINDING

ACSL6 ACSL5

1.18e-0328342PS00455
DomainPROTEIN_KINASE_ATP

OBSCN STK39 OXSR1 RPS6KA5 MAP3K4

1.36e-03459345PS00107
DomainAMP-binding

ACSL6 ACSL5

1.36e-0330342PF00501
DomainAMP-dep_Synth/Lig

ACSL6 ACSL5

1.36e-0330342IPR000873
DomainProt_kinase_dom

OBSCN STK39 OXSR1 RPS6KA5 MAP3K4

1.79e-03489345IPR000719
DomainPROTEIN_KINASE_DOM

OBSCN STK39 OXSR1 RPS6KA5 MAP3K4

1.86e-03493345PS50011
DomainKinase-like_dom

OBSCN STK39 OXSR1 RPS6KA5 MAP3K4

2.80e-03542345IPR011009
DomainSH3_1

SRGAP2 SRGAP1 SH3YL1

3.26e-03164343PF00018
DomainCUB

ATRN TMPRSS7

3.59e-0349342PF00431
DomainCUB

ATRN TMPRSS7

3.73e-0350342SM00042
Domain-

ATRN TMPRSS7

4.03e-03523422.60.120.290
DomainCUB

ATRN TMPRSS7

4.18e-0353342PS01180
DomainCUB_dom

ATRN TMPRSS7

4.82e-0357342IPR000859
DomainRhoGAP

SRGAP2 SRGAP1

5.68e-0362342SM00324
DomainRhoGAP

SRGAP2 SRGAP1

5.86e-0363342PF00620
DomainRHOGAP

SRGAP2 SRGAP1

6.04e-0364342PS50238
DomainRhoGAP_dom

SRGAP2 SRGAP1

6.04e-0364342IPR000198
Domain-

SRGAP2 SRGAP1

6.04e-03643421.10.555.10
Domain-

CPXM2 FBXO2

7.80e-03733422.60.120.260
DomainEGF_3

ATRN ADGRE5 HEG1

8.83e-03235343PS50026
DomainEGF

ATRN ADGRE5 HEG1

8.83e-03235343SM00181
DomainC_TYPE_LECTIN_1

ATRN MRC2

9.30e-0380342PS00615
DomainLectin_C

ATRN MRC2

1.02e-0284342PF00059
DomainCLECT

ATRN MRC2

1.02e-0284342SM00034
DomainEGF-like_dom

ATRN ADGRE5 HEG1

1.03e-02249343IPR000742
DomainC_TYPE_LECTIN_2

ATRN MRC2

1.04e-0285342PS50041
DomainC-type_lectin-like

ATRN MRC2

1.07e-0286342IPR001304
DomainEGF_CA

ADGRE5 HEG1

1.07e-0286342PF07645
DomainRho_GTPase_activation_prot

SRGAP2 SRGAP1

1.12e-0288342IPR008936
DomainGalactose-bd-like

CPXM2 FBXO2

1.27e-0294342IPR008979
PathwayWP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES

ACSL6 SSC5D CD5L APOBR MRC2 CD163 ACSL5

2.32e-06381247M48063
PathwayREACTOME_INACTIVATION_OF_CDC42_AND_RAC1

SRGAP2 SRGAP1

7.73e-058242M27349
PathwayKEGG_MEDICUS_REFERENCE_BETA_OXIDATION_ACYL_COA_SYNTHESIS

ACSL6 ACSL5

1.51e-0411242M47626
PathwayWP_FATTY_ACID_TRANSPORTERS

ACSL6 ACSL5

4.18e-0418242M42570
PathwayWP_FATTY_ACID_BIOSYNTHESIS

ACSL6 ACSL5

6.28e-0422242M39440
PathwayREACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS

ACSL6 ACSL5

6.28e-0422242MM15451
PathwayWP_FATTY_ACID_BIOSYNTHESIS

ACSL6 ACSL5

6.88e-0423242MM15885
PathwayREACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS

ACSL6 ACSL5

7.49e-0424242M1016
PathwayREACTOME_FATTY_ACYL_COA_BIOSYNTHESIS

ACSL6 ACSL5

1.34e-0332242MM15446
PathwayWP_FATTY_ACID_BETAOXIDATION

ACSL6 ACSL5

1.51e-0334242M39596
PathwayWP_FATTY_ACID_BETAOXIDATION

ACSL6 ACSL5

1.51e-0334242MM15937
PathwayREACTOME_FATTY_ACYL_COA_BIOSYNTHESIS

ACSL6 ACSL5

1.78e-0337242M729
PathwayKEGG_FATTY_ACID_METABOLISM

ACSL6 ACSL5

2.29e-0342242M699
Pubmed

Role of the WNK-activated SPAK kinase in regulating blood pressure.

STK39 OXSR1

9.28e-07234220091762
Pubmed

Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.

STK39 OXSR1

9.28e-07234216382158
Pubmed

Calcium-binding protein 39 facilitates molecular interaction between Ste20p proline alanine-rich kinase and oxidative stress response 1 monomers.

STK39 OXSR1

9.28e-07234223034389
Pubmed

SPAK and OSR1 Sensitive Kir2.1 K+ Channels.

STK39 OXSR1

9.28e-07234226673921
Pubmed

Regulation of NKCC2 activity by SPAK truncated isoforms.

STK39 OXSR1

9.28e-07234224173353
Pubmed

The Ste20 kinases SPAK and OSR1 travel between cells through exosomes.

STK39 OXSR1

9.28e-07234227122160
Pubmed

SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels.

STK39 OXSR1

9.28e-07234226584301
Pubmed

Identification of SRGAP2 as a potential oncogene and a prognostic biomarker in hepatocellular carcinoma.

SRGAP2 SRGAP1

9.28e-07234233984363
Pubmed

Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.

STK39 OXSR1

9.28e-07234224191005
Pubmed

Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains.

STK39 OXSR1

2.78e-06334234726826
Pubmed

Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke.

STK39 OXSR1

2.78e-06334226861815
Pubmed

Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.

STK39 OXSR1

2.78e-06334225515571
Pubmed

SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule.

STK39 OXSR1

2.78e-06334227068441
Pubmed

Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb (SLC34A2) by the Kinases SPAK and OSR1.

STK39 OXSR1

2.78e-06334226506223
Pubmed

WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

STK39 OXSR1

2.78e-06334216263722
Pubmed

OSR1 and SPAK cooperatively modulate Sertoli cell support of mouse spermatogenesis.

STK39 OXSR1

2.78e-06334227853306
Pubmed

Negative regulation of the creatine transporter SLC6A8 by SPAK and OSR1.

STK39 OXSR1

2.78e-06334225531585
Pubmed

SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.

STK39 OXSR1

2.78e-06334224039833
Pubmed

STK39 is an independent risk factor for male hypertension in Han Chinese.

STK39 OXSR1

2.78e-06334220889219
Pubmed

SPAK and OSR1 kinases bind and phosphorylate the β2-Adrenergic receptor.

STK39 OXSR1

2.78e-06334232828531
Pubmed

Regulation of ClC-2 activity by SPAK and OSR1.

STK39 OXSR1

2.78e-06334225323061
Pubmed

The Ste20 kinases Ste20-related proline-alanine-rich kinase and oxidative-stress response 1 regulate NKCC1 function in sensory neurons.

STK39 OXSR1

2.78e-06334219307180
Pubmed

Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system.

SRGAP2 SRGAP1

2.78e-06334219137586
Pubmed

SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner.

STK39 OXSR1

2.78e-06334222977235
Pubmed

Molecular components of signal amplification in olfactory sensory cilia.

STK39 OXSR1

2.78e-06334220231443
Pubmed

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.

STK39 OXSR1

2.78e-06334218270262
Pubmed

SPAK and OSR1 Sensitivity of Excitatory Amino Acid Transporter EAAT3.

STK39 OXSR1

2.78e-06334226112741
Pubmed

Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.

STK39 OXSR1

5.56e-06434221486947
Pubmed

SPAK and OSR1 dependent down-regulation of murine renal outer medullary K channel ROMK1.

STK39 OXSR1

5.56e-06434225322850
Pubmed

Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.

STK39 OXSR1

5.56e-06434225362046
Pubmed

Down-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by the Kinases SPAK and OSR1.

STK39 OXSR1

5.56e-06434226233565
Pubmed

Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride.

STK39 OXSR1

5.56e-06434225565204
Pubmed

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.

STK39 OXSR1

5.56e-06434216669787
Pubmed

WNK kinases sense molecular crowding and rescue cell volume via phase separation.

STK39 OXSR1

9.26e-06534236318922
Pubmed

Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway.

ACSL6 ACSL5

9.26e-06534224269233
Pubmed

Sites of regulated phosphorylation that control K-Cl cotransporter activity.

STK39 OXSR1

9.26e-06534219665974
Pubmed

Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.

ACSL6 ACSL5

9.26e-06534215292367
Pubmed

Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone.

STK39 OXSR1

9.26e-06534218800028
Pubmed

Novel mechanisms of Na+ retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK.

STK39 OXSR1

9.26e-06534224808538
Pubmed

The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.

ACSL6 ACSL5

9.26e-06534222633490
Pubmed

A SPAK isoform switch modulates renal salt transport and blood pressure.

STK39 OXSR1

9.26e-06534221907141
Pubmed

Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone.

STK39 OXSR1

9.26e-06534219008908
Pubmed

SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance.

SRGAP2 SRGAP1

1.39e-05634233514561
Pubmed

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.

STK39 OXSR1

1.39e-05634221423148
Pubmed

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.

STK39 OXSR1

1.39e-05634221321328
Pubmed

FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains.

SRGAP2 SRGAP1

1.39e-05634212736724
Pubmed

Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.

SRGAP2 SRGAP1

1.39e-05634211672528
Pubmed

Evidence for a role of srGAP3 in the positioning of commissural axons within the ventrolateral funiculus of the mouse spinal cord.

SRGAP2 SRGAP1

1.94e-05734221655271
Pubmed

Ontogeny of mRNA expression and activity of long-chain acyl-CoA synthetase (ACSL) isoforms in Mus musculus heart.

ACSL6 ACSL5

1.94e-05734217197235
Pubmed

Critical role of WNK1 in MYC-dependent early mouse thymocyte development.

STK39 OXSR1

2.59e-05834233051000
Pubmed

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.

STK39 OXSR1

2.59e-05834224393035
Pubmed

The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner.

STK39 OXSR1

2.59e-05834231614064
Pubmed

WNK1 kinase balances T cell adhesion versus migration in vivo.

STK39 OXSR1

2.59e-05834227400149
Pubmed

Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).

STK39 OXSR1

2.59e-05834212386165
Pubmed

B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice.

STK39 OXSR1

3.33e-05934236662229
Pubmed

Multifaceted Regulation of Akt by Diverse C-Terminal Post-translational Modifications.

AMBRA1 OXSR1 TBCE

4.28e-056934334941261
Pubmed

The DNA sequence and biological annotation of human chromosome 1.

OBSCN EXTL1 CD5L MORN1 RAB3GAP2 FBXO2 TBCE

5.26e-05103134716710414
Pubmed

Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.

STK39 OXSR1

6.08e-051234227782176
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

OBSCN AMBRA1 SRGAP2 HEG1 MORN1 TBC1D9 BAP1

8.14e-05110534735748872
Pubmed

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ACSL6 RAB3GAP2 TBC1D9

1.29e-0410034310048485
Pubmed

Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.

SRGAP2 SRGAP1 TBCE

1.72e-0411034327889896
Pubmed

Biosynthesis of triacylglycerols.

ACSL6 ACSL5

3.45e-04283428944226
GeneFamilyRho GTPase activating proteins|F-BAR domain containing

SRGAP2 SRGAP1

3.52e-04232221288
GeneFamilyAcyl-CoA synthetase family

ACSL6 ACSL5

4.51e-042622240
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

SSC5D CD163

4.87e-04272221253
GeneFamilyRho GTPase activating proteins|BCH domain containing

SRGAP2 SRGAP1

1.67e-0350222721
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ADGRE5 MRC2 CD163

1.16e-02394223471
CoexpressionGSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_DN

SRGAP2 RPS6KA5 RAB3GAP2 ACSL5 CEMIP

5.58e-06199345M5799
CoexpressionZHOU_INFLAMMATORY_RESPONSE_FIMA_UP

MORN1 RPS6KA5 SRGAP1 RAB3GAP2 TBC1D9 CEMIP

4.81e-05517346M7140
CoexpressionGSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN

ADGRE5 SRGAP2 HEG1 MAP3K4

8.49e-05180344M6878
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

ATRN STK39 SRGAP2 HEG1 OXSR1 MAP3K4 CEMIP

9.62e-05856347M4500
CoexpressionGSE30971_CTRL_VS_LPS_STIM_MACROPHAGE_WBP7_KO_4H_UP

TBC1D9 ACSL5 MAP3K4 CEMIP

1.18e-04196344M8714
CoexpressionGSE28783_ANTI_MIR33_VS_UNTREATED_ATHEROSCLEROSIS_MACROPHAGE_UP

ADGRE5 EXTL1 CD5L BAP1

1.25e-04199344M8351
CoexpressionGSE43863_TH1_VS_LY6C_INT_CXCR5POS_MEMORY_CD4_TCELL_DN

ADGRE5 CD5L MORN1 RPS6KA5

1.28e-04200344M9757
CoexpressionGSE19888_ADENOSINE_A3R_ACT_VS_TCELL_MEMBRANES_ACT_IN_MAST_CELL_UP

SSC5D ADGRE5 APOBR MRC2

1.28e-04200344M7333
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SSC5D CPXM2 APOBR MRC2 CEMIP

1.59e-07165345570483b43ccb5831feec9337b4664814431d40b1
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SSC5D CPXM2 APOBR MRC2 CEMIP

1.59e-071653452026a9a07f4d314cc05c167e491312b373468e46
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACSL6 EXTL1 TMPRSS7 FBXO2 CEMIP

2.20e-0717634577c3da2eaa072a6baefb5087fd07ec18c5e271cd
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SSC5D CPXM2 MRC2 CEMIP

3.07e-06132344560e836764ed7806fb18282dfebe434d30112a9a
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SSC5D APOBR MRC2 CEMIP

6.41e-06159344cb2470b288c13e454a2a80115b0d5613b3f718e6
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EXTL1 TMPRSS7 FBXO2 CEMIP

9.36e-06175344f1394aacc8a94ca555dd19aaed5a18da99c6bf40
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EXTL1 TMPRSS7 FBXO2 CEMIP

9.36e-061753447bf1194d93fbe2dbf9d953e0a32b2a6d88251ed1
ToppCellP03-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ACSL6 EXTL1 CPXM2 FBXO2

1.00e-051783448591a40fced747ac16b3e8ebc7a22dfb3ad76da2
ToppCell343B-Fibroblasts-Fibroblast-E|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

AMBRA1 SSC5D STK39 SRGAP2

1.17e-0518534402cbf492bc40abebaa93a3a208888afae72fbe06
ToppCell343B-Fibroblasts-Fibroblast-E-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

AMBRA1 SSC5D STK39 SRGAP2

1.17e-051853441b8e3ddb91797f84e4b15d2457b0c008e5be50db
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ADGRE5 SRGAP2 SRGAP1 CD163

1.29e-051903442d54fca50593fbd11fe13fc2bfaf937a05db776d
ToppCellASK454-Mesenchymal-Fibroblast|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

SSC5D HEG1 SRGAP1 CEMIP

1.32e-051913441726add3f392a061536b7aff72ba84303f4a0b1f
ToppCellASK454-Mesenchymal|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

SSC5D HEG1 SRGAP1 CEMIP

1.32e-05191344e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCell5'-Adult-SmallIntestine-Hematopoietic-Myeloid-cDC2|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SRGAP2 SRGAP1 CD163 TBC1D9

1.35e-0519234490274b85f3d612b6a6d435860cd6d049ddeb1d96
ToppCellCOPD-Myeloid-Macrophage|World / Disease state, Lineage and Cell class

SRGAP2 SRGAP1 CD163 TBC1D9

1.40e-051943447d682408e9a6239a4e47befc9376e760cc3d133a
ToppCell15-Airway-Mesenchymal-Cartilage|Airway / Age, Tissue, Lineage and Cell class

EXTL1 CPXM2 SRGAP1 FBXO2

1.43e-05195344414f60bc0f0d0ecb5137bcd617fae91f0c15038a
ToppCellILEUM-non-inflamed-(3)_moDC|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

APOBR SRGAP1 CD163 TBC1D9

1.46e-05196344e10f01172fd076d6892906853f9375d4c3058951
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EXTL1 CPXM2 FBXO2 CEMIP

1.49e-05197344ece0c17eb68f394b20e588c0b0626d3987a4dbbb
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EXTL1 CPXM2 FBXO2 CEMIP

1.49e-051973444b6c0e028b9669c102df8e9dc63e284f8d5fd9ee
ToppCellTCGA-Skin-Metastatic-Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

HEG1 CD163 RAB3GAP2 TBC1D9

1.52e-05198344af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRN ACSL6 AMFR FBXO2

1.52e-05198344a7e5de81eb7d3d23812c179a001adbaab1506596
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

HEG1 CD163 RAB3GAP2 TBC1D9

1.52e-0519834462cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCellTCGA-Skin-Metastatic|TCGA-Skin / Sample_Type by Project: Shred V9

HEG1 CD163 RAB3GAP2 TBC1D9

1.52e-05198344ad39cce004867f083f8da1954e0cf5a263815184
ToppCellCOPD-Myeloid-Macrophage|COPD / Disease state, Lineage and Cell class

SRGAP2 SRGAP1 CD163 TBC1D9

1.55e-051993444b9c53fb4f44190d2f6ad4d52b13be01ebe4955e
ToppCell3'_v3-GI_small-bowel-Myeloid_Mac-Intestinal_macrophages|GI_small-bowel / Manually curated celltypes from each tissue

MRC2 SRGAP1 CD163 TBC1D9

1.55e-0519934496070b5ffcbab4952970f43b536969ddd2ca5d14
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Mgp_(Mgp)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

SSC5D CPXM2 MRC2

7.42e-0510734313af691c8533418d2800a8eca61155896b559948
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Mgp_(Mgp)|Hippocampus / BrainAtlas - Mouse McCarroll V32

SSC5D CPXM2 MRC2

7.42e-05107343a5a34bb9706527799ddb494d4f1bfc634c29e8a9
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast-matrix_-_mature_2|E18.5-samps / Age Group, Lineage, Cell class and subclass

SSC5D OXSR1 CD163

1.35e-04131343f2eee150f5cff852e8f52f09b35e26f17d80833b
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Hippocampus / BrainAtlas - Mouse McCarroll V32

SSC5D CPXM2 MRC2

1.44e-04134343b959899c89d3a0363a3cd2309155280e0fe5ba88
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

AMFR APOBR MRC2

1.71e-04142343671ba8869db7a6dc69fd1caf0e561f15a312b170
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

AMFR APOBR MRC2

1.71e-041423433557084150670fd2e2634fc674f228ab85181b59
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Alcam_(Alcam)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

AMFR APOBR MRC2

1.71e-041423436a656d28c9f5dfb03a3a2d908cf2edbe0a5b1206
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Alcam_(Alcam)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

AMFR APOBR MRC2

1.71e-04142343a3d1f4b570b75402171e38c5a7c88e2896520c8f
ToppCellCerebellum-Endothelial-ENDOTHELIAL_TIP|Cerebellum / BrainAtlas - Mouse McCarroll V32

SSC5D MRC2 CEMIP

1.98e-041493433980fa4f1986a2f164a1826ea043fb71f1d756cd
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Thalamus / BrainAtlas - Mouse McCarroll V32

SSC5D CPXM2 MRC2

2.14e-04153343e9c6fb5c41adb6595c66c3a917fe455348279e54
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Thalamus / BrainAtlas - Mouse McCarroll V32

SSC5D CPXM2 MRC2

2.14e-04153343b8b5ff7d2feea3e3a352fb5530e49f639fe1ff88
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP|Thalamus / BrainAtlas - Mouse McCarroll V32

SSC5D CPXM2 MRC2

2.14e-041533432513edfae62a44e51d3556675a096723194c966c
ToppCell10x5'-Liver-Lymphocytic_T_CD4/8-lo-Trm_Tgd|Liver / Manually curated celltypes from each tissue

DNAI7 RPS6KA5 MAP3K4

2.18e-04154343c6308074468235c88ef4ea43ab155d9f86cbf261
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC2 SRGAP1 MAP3K4

2.22e-0415534382e602f31981c6b48abff2a04b2ab5d26d4462a2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC2 SRGAP1 MAP3K4

2.22e-04155343979c1d53b435a82c57d16707eed8ba7346326866
ToppCell10x5'-Liver-Myeloid_Mac-Intestinal_macrophages|Liver / Manually curated celltypes from each tissue

CD5L MRC2 CD163

2.26e-041563439a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCelldroplet-Kidney-KIDNEY-1m-Lymphocytic-lymphocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D CD163 TBC1D9

2.39e-041593433bab00f8fb7d9232538e50f83dd0fd70ddd16819
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STK39 CPXM2 TBC1D9

2.44e-041603432d391ba6f7adb55dfa89feecc10cc9ce97e5fe74
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STK39 CPXM2 TBC1D9

2.44e-041603438bcdbcfdf1e0ace6053e8de82762f6e2f86bba7a
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

MRC2 CD163 ACSL5

2.44e-041603438bb873704895c3b35bba8af78fedbabf7df42e71
ToppCellLPS-antiTNF-Myeloid-Monocytes,_Macrophages-Neutrophils|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZBTB3 MORN1 CD163

2.44e-041603435d8d97c3da5837ba5fe743d2f8438f5cb7cea64b
ToppCelldroplet-Kidney-KIDNEY-1m-Lymphocytic-CD45|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D CD163 TBC1D9

2.44e-041603435bec867def73fa8531f8dad611679f4b44f573bd
ToppCelldroplet-Thymus-nan-21m-Myeloid-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OBSCN CD5L TBC1D9

2.48e-04161343441ebd3c029861d833fbcf8a68fc740d9de8ef2f
ToppCelldroplet-Spleen-nan-18m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK39 APOBR SRGAP1

2.57e-04163343bc37c5d9f48b16096d5313657563f3ec84028c8c
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-TRGV4_gdT|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AMBRA1 APOBR FBXO2

2.67e-041653439f6f3a614ac614488e9f59cf2805467ff075ccca
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACSL6 SSC5D APOBR

2.76e-041673432184c2760b6142e62124a2454a552723e20d4f61
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

AMBRA1 SRGAP1 FBXO2

2.81e-041683438459d0a1bf6d4b5c83001097331f8b78fceb9305
ToppCelldroplet-Lung-nan-18m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EXTL1 MORN1 TBC1D9

2.81e-0416834396f7411474edd673b8d3ee6b8a8bb185c246daaf
ToppCellfacs-Liver-Hepatocytes-24m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD5L CD163 TBC1D9

2.81e-041683434ae9e9d93bcd6f4d5815e57fd5afa7a3398a0ec1
ToppCellfacs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD5L CD163 TBC1D9

2.86e-04169343454b92b9b67299a64278c010db033ca5b9d217a0
ToppCelldroplet-Kidney-nan-18m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAI7 MRC2 SRGAP1

2.86e-0416934387116c33c5ca8cb1862e103e5607b1df4d264569
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEG1 CD5L TMPRSS7

2.91e-04170343a121e10099faaeb60251eec162f38caf7c4238c2
ToppCellwk_20-22-Mesenchymal-Chondrocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

EXTL1 CPXM2 TBCE

2.96e-04171343d2938639e9a7c349e5a6ec61724222f9d127c89f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC2 SRGAP1 MAP3K4

2.96e-04171343972fab891135bd755d5526cbc5a963200067b0a6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC2 SRGAP1 MAP3K4

2.96e-041713432a77ed79c6f2e700e789c80451a70ecb31639719
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD5L APOBR TBC1D9

3.01e-04172343584af6537685cb459bf0fc298e6f46872016c116
ToppCellfacs-Trachea-nan-24m-Mesenchymal-chondrocyte|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EXTL1 FBXO2 CEMIP

3.06e-041733432226505610af1becc253d0a5550627144ef0ed6b
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage|368C / Donor, Lineage, Cell class and subclass (all cells)

ADGRE5 APOBR CD163

3.06e-04173343bba8265a58f8f5659dc7b9da2fe27b15033fce34
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 HEG1 ACSL5

3.06e-04173343f193c63cc536d891c9d23043765e320252bb6e65
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATRN CD5L APOBR

3.06e-0417334320f7dfe7d92a3dbec9da9a1f3185aa10cb8f0a3c
ToppCelldroplet-Liver-Npc-18m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD5L CD163 TBC1D9

3.06e-041733439ba55e21d1037ec3150d77895e52f0b051df65da
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD5L APOBR CD163

3.11e-041743433533a47885af453d97739e5576e989d93d31be32
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_macrophage-macrophage|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CD5L SRGAP1 CD163

3.11e-041743432479e4804253f55647d2192e40566d713419c51b
ToppCell10x5'-bone_marrow-Myeloid_Mac-Intestinal_macrophages|bone_marrow / Manually curated celltypes from each tissue

SSC5D CD163 TBC1D9

3.11e-041743430746344d62aa7ab77c378e9d5a9f9238e741a76b
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_macrophage|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CD5L SRGAP1 CD163

3.11e-041743437f1e26b58b66f4ac4c3bc315354bd620ad782eaa
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB3 CD163 TRMT61A

3.11e-04174343ff13a5c55d18b951315908f33cb47c7f9cb901bf
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD5L APOBR CD163

3.11e-04174343b487c5c46f074a69b9526a2c72daf218f66aa44b
ToppCelldroplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MORN1 APOBR TBC1D9

3.17e-041753434655d3daa95e8ffa7d5ee4180de06b2fec361bfb
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD5L DNAI7 TBC1D9

3.22e-041763435e46a09a36b9645b1b1fcb0b64bd0898561af3a9
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD5L DNAI7 TBC1D9

3.27e-0417734314fb8d182775dfd0e49aa7e4e12543a85b3b8bd6
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-chondrocyte|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

EXTL1 CPXM2 FBXO2

3.27e-04177343915b848d789051a1c3bc6f6dc86955bb752276ab
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADGRE5 APOBR CD163

3.33e-041783430b398656f26c4061b11ccf98908d0e2e1367585a
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

HEG1 EXTL1 CPXM2

3.38e-041793438c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

OXSR1 CD163 CEMIP

3.38e-0417934387f608b137aae34572b150492a83a3a127cff40b
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-Macrophages|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SRGAP2 SRGAP1 CD163

3.55e-04182343ea39b1b5db185b0cb11dfa2e01f3f972effbd770
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CPXM2 TRMT61A CEMIP

3.55e-04182343a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCellwk_20-22-Mesenchymal-Chondrocyte-Resting_chondrocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

EXTL1 CPXM2 TBCE

3.55e-0418234303a5a02acd48f0eb210485348bfe0cd21f486215
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STK39 CPXM2 TBC1D9

3.61e-041833432e831a4d99c6f983793df71c0994124c943c6da9
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SSC5D CPXM2 MRC2

3.67e-041843434a9f798c67b9998bffe44242b210cc1e224ff5b1
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CACNG5|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADGRE5 CPXM2 CEMIP

3.67e-04184343658f2e522055e88c92bc482a845c40f8f5f1a8e3
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D MRC2 SRGAP1

3.73e-041853433cd0686a14e734a0f243070ab939adcb4c454478
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D MRC2 SRGAP1

3.73e-0418534300258f458cbf6d36449db95528a6b5038d731d2d
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D MRC2 SRGAP1

3.73e-04185343a94694e226856bc5b168464f52d76004145717a5
ToppCellwk_08-11-Hematologic-Myeloid-APOE+_Mac2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CD5L APOBR CD163

3.73e-041853438f843badc0e26cb7300c83db56c7974beb90fcf3
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

EXTL1 CPXM2 FBXO2

3.73e-041853438ed10ba581849c9c4ac4397226be2b62b4b3b900
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATRN SRGAP1 CD163

3.73e-041853438207f9eff113eed429e961748c6b17d672a13b33
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STK39 HEG1 RPS6KA5

3.73e-0418534387151ab95530e70d61328b336518df58db584acb
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

EXTL1 CPXM2 FBXO2

3.73e-04185343b8052cebb73f41abe6faf0aa847be7c8ef23ae94
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-chondrocyte|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

EXTL1 CPXM2 FBXO2

3.79e-0418634380a0a42ca8585cdb1dda57a18c254316a126ee64
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADGRE5 SRGAP2 TBC1D9

3.79e-0418634355b239834b96b1f7787ec77a7d19796d617bbbf0
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STK39 CPXM2 TBC1D9

3.91e-04188343eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCell10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-chondrocyte|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

EXTL1 CPXM2 FBXO2

3.91e-041883435a89587ee6f2b4dc14244bd88bb31efb81c50dbe
ToppCellMesenchymal-chondrocyte|World / Lineage, Cell type, age group and donor

EXTL1 CPXM2 FBXO2

3.91e-041883437b1e3f8a941eaa68e89c562129a92314642eec66
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STK39 CPXM2 TBC1D9

3.91e-04188343bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 MRC2 SRGAP1

3.91e-04188343047c4e0b03fc8334e38c48977e41d26dbe229d47
DrugSulfamethoxazole [723-46-6]; Down 200; 15.8uM; HL60; HT_HG-U133A

AMBRA1 SRGAP2 AAMDC MRC2 TRMT61A

9.23e-061923452335_DN
DrugDanazol [17230-88-5]; Up 200; 11.8uM; HL60; HG-U133A

AMFR HEG1 MRC2 FBXO2 TRMT61A

1.05e-051973452038_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

HEG1 DNAI7 RPS6KA5 AAMDC

1.46e-041803443510_UP
DrugTrichostatin A, Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

ADGRE5 DNAI7 RPS6KA5 AAMDC

1.52e-041823446932_UP
Drugtrichostatin A; Up 200; 0.1uM; MCF7; HG-U133A

ADGRE5 HEG1 RPS6KA5 AAMDC

1.79e-04190344331_UP
Drug11-deoxy-16,16-dimethyl Prostaglandin E2; Up 200; 10uM; PC3; HT_HG-U133A

AMFR HEG1 ZBTB3 CEMIP

1.83e-041913447538_UP
Drugstaurosporine; Up 200; 0.01uM; MCF7; HG-U133A

MRC2 RAB3GAP2 MAP3K4 CEMIP

1.90e-04193344425_UP
DrugTestosterone propionate [57-85-2]; Up 200; 11.6uM; MCF7; HT_HG-U133A

HEG1 MORN1 FBXO2 CEMIP

1.90e-041933445271_UP
Drug(-)-depudecin; Up 200; 1uM; MCF7; HT_HG-U133A_EA

HEG1 RPS6KA5 AAMDC CEMIP

1.90e-04193344982_UP
Drug2-propylpentanoic acid; Down 200; 1000uM; PC3; HT_HG-U133A

AMBRA1 ZBTB3 FBXO2 BAP1

1.94e-041943441209_DN
DrugThioguanosine [85-31-4]; Down 200; 12.6uM; HL60; HT_HG-U133A

ATRN AAMDC RAB3GAP2 TBCE

1.94e-041943441264_DN
DrugAcebutolol hydrochloride [34381-68-5]; Down 200; 10.8uM; HL60; HG-U133A

SRGAP2 RPS6KA5 RAB3GAP2 TRMT61A

2.02e-041963441993_DN
DrugTocopherol (R,S) [10191-41-0]; Up 200; 9.2uM; MCF7; HT_HG-U133A

AMBRA1 HEG1 MRC2 MAP3K4

2.02e-041963443256_UP
DrugZidovudine, AZT [30516-87-1]; Down 200; 15uM; MCF7; HT_HG-U133A

RPS6KA5 RAB3GAP2 MAP3K4 TRMT61A

2.02e-041963445333_DN
DrugMuramic acid, N-acetyl [10597-89-4]; Up 200; 13.6uM; MCF7; HT_HG-U133A

EXTL1 DNAI7 MORN1 RAB3GAP2

2.02e-041963444406_UP
DrugGallamine triethiodide [65-29-2]; Up 200; 4.4uM; PC3; HT_HG-U133A

AMBRA1 SRGAP2 DNAI7 TBC1D9

2.06e-041973442059_UP
DrugRapamycin; Down 200; 0.1uM; HL60; HT_HG-U133A

AMBRA1 AMFR AAMDC TRMT61A

2.06e-041973441183_DN
DrugSulindac [38194-50-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A

ATRN AMFR ADGRE5 RPS6KA5

2.06e-041973441693_DN
DrugLincomycin hydrochloride [859-18-7]; Up 200; 9uM; HL60; HT_HG-U133A

AMFR MORN1 RAB3GAP2 TBC1D9

2.06e-041973442380_UP
DrugChlorzoxazone [95-25-0]; Down 200; 23.6uM; MCF7; HT_HG-U133A

ATRN AMBRA1 ADGRE5 AAMDC

2.10e-041983447456_DN
Drugrotenone; Down 200; 1uM; MCF7; HT_HG-U133A

HEG1 ZBTB3 MRC2 FBXO2

2.10e-041983445943_DN
DrugChlorzoxazone [95-25-0]; Down 200; 23.6uM; PC3; HT_HG-U133A

AMFR ZBTB3 RPS6KA5 TRMT61A

2.10e-041983442100_DN
DrugDehydrocholic acid [81-23-2]; Down 200; 9.6uM; PC3; HG-U133A

AMFR HEG1 RPS6KA5 AAMDC

2.10e-041983441940_DN
DrugFusidic acid sodium salt [751-94-0]; Down 200; 7.4uM; MCF7; HT_HG-U133A

RPS6KA5 AAMDC BAP1 TRMT61A

2.14e-041993445353_DN
DrugFlunixin meglumine [42461-84-7]; Up 200; 8.2uM; MCF7; HT_HG-U133A

MORN1 RPS6KA5 RAB3GAP2 FBXO2

2.14e-041993444735_UP
DrugSulfamerazine [127-79-7]; Up 200; 15.2uM; PC3; HT_HG-U133A

DNAI7 MRC2 RAB3GAP2 ACSL5

2.14e-041993443718_UP
DrugEstriol [50-27-1]; Down 200; 13.8uM; PC3; HT_HG-U133A

AMBRA1 AMFR AAMDC TBCE

2.14e-041993445866_DN
DrugLisinopril [83915-83-7]; Down 200; 9uM; MCF7; HT_HG-U133A

AMFR SRGAP2 RAB3GAP2 TRMT61A

2.14e-041993447403_DN
DrugZimelidine dihydrochloride monohydrate [61129-30-4]; Up 200; 9.8uM; HL60; HG-U133A

AMBRA1 AAMDC MRC2 TBCE

2.14e-041993442012_UP
DrugCyclopenthiazide [742-20-1]; Down 200; 10.6uM; HL60; HT_HG-U133A

ATRN MRC2 RAB3GAP2 BAP1

2.18e-042003442905_DN
DrugUrosiol [128-13-2]; Down 200; 10.2uM; HL60; HT_HG-U133A

HEG1 ZBTB3 MRC2 TRMT61A

2.18e-042003443105_DN
Diseasetriacylglycerol 48:0 measurement

AMFR MORN1

4.12e-0426342EFO_0010403
DiseaseLiver Cirrhosis, Experimental

ATRN EXTL1 CD5L CD163 TBC1D9

1.82e-03774345C0023893
DiseaseRS-10-hydroxywarfarin to RS-warfarin ratio measurement

ATRN ACSL6

7.15e-03110342EFO_0803335

Protein segments in the cluster

PeptideGeneStartEntry
GGSRTWDWRETGTEH

AAMDC

31

Q9H7C9
AFWKSDSDRGGHWAT

ADGRE5

496

P48960
IDHGPWGEDEEWTDK

BAP1

191

Q92560
HKGVWGSVCDDNWGE

CD5L

261

O43866
RIWDLHGGSESWFTD

AMBRA1

121

Q9C0C7
DHGAWLRGGDVWLDS

CEMIP

791

Q8WUJ3
ELGGWSLGRWTHDGI

CPXM2

436

Q8N436
GRLHKTEDGGWEWSD

OXSR1

326

O95747
ITGEGRRHWAWSGDT

MORN1

71

Q5T089
RDPSKSTDWEDDGWG

RAB3GAP2

36

Q9H2M9
ASGWLGWKSKHEEEA

RAB3GAP2

346

Q9H2M9
ALAGRSGGPHWDWDV

ATRN

21

O75882
WCDVEHGGDGWRVEE

FBXO2

136

Q9UK22
EEDHGCRKGWTWHSP

MRC2

516

Q9UBG0
RGGDSGHDKAVDWWS

RPS6KA5

226

O75582
RGGSADAAWKHWPES

HEG1

101

Q9ULI3
EWWKGHETLRDGDRH

OBSCN

3656

Q5VST9
WDAEGKHWRTDGISN

DNAI7

456

Q6TDU7
DSDGWLHTGDIGRWL

ACSL5

516

Q9ULC5
RGNESALWDCKHDGW

CD163

121

Q86VB7
HGDRARDSEDSWGTW

MAP3K4

906

Q9Y6R4
ASEDWWEGRHNGIDG

SRGAP1

776

Q7Z6B7
TDSHFDWWEGKLRGQ

SH3YL1

316

Q96HL8
HGGRWGSVCDDAWDL

SSC5D

321

A1L4H1
WDEAHGGWGYTAERT

EXTL1

531

Q92935
LWDLNHEGTWEGKGT

AMFR

241

Q9UKV5
DSDGWLHTGDIGKWL

ACSL6

531

Q9UKU0
GMARGAESEWTWHGE

APOBR

191

Q0VD83
AESEWTWHGETEGKA

APOBR

196

Q0VD83
WLGVEWDNPERGKHD

TBCE

36

Q15813
SGEKCWVTGWGRRHE

TMPRSS7

726

Q7RTY8
WVTGWGRRHEADNKG

TMPRSS7

731

Q7RTY8
ASDDWWEGRHNGIDG

SRGAP2

761

O75044
WEAVGHAWDALKVEG

TRMT61A

186

Q96FX7
GGSRKEITEHWEWLE

TBC1D9

81

Q6ZT07
SGHLHKTEDGDWEWS

STK39

371

Q9UEW8
ETSGHWGKGEWKGSA

ZBTB3

211

Q9H5J0