Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Bilateral choanal atresia	FOXE1 KMT2D DCHS1	1.09e-05	9	27	3	HP:0004502
Domain	PDZ	MAGI1 SHROOM3 ARHGAP23 PARD6G PRX MAST3	7.40e-05	141	93	6	PF00595
Domain	PDZ	MAGI1 SHROOM3 ARHGAP23 PARD6G PRX MAST3	9.67e-05	148	93	6	SM00228
Domain	-	MAGI1 SHROOM3 ARHGAP23 PARD6G PRX MAST3	1.04e-04	150	93	6	2.30.42.10
Domain	PDZ	MAGI1 SHROOM3 ARHGAP23 PARD6G PRX MAST3	1.08e-04	151	93	6	PS50106
Domain	PDZ	MAGI1 SHROOM3 ARHGAP23 PARD6G PRX MAST3	1.12e-04	152	93	6	IPR001478
Domain	FYrich_C	KMT2B KMT2D	2.43e-04	5	93	2	IPR003889
Domain	FYrich_N	KMT2B KMT2D	2.43e-04	5	93	2	IPR003888
Domain	FYRC	KMT2B KMT2D	2.43e-04	5	93	2	SM00542
Domain	FYRN	KMT2B KMT2D	2.43e-04	5	93	2	SM00541
Domain	FYRN	KMT2B KMT2D	2.43e-04	5	93	2	PF05964
Domain	FYRC	KMT2B KMT2D	2.43e-04	5	93	2	PF05965
Domain	FYRC	KMT2B KMT2D	2.43e-04	5	93	2	PS51543
Domain	FYRN	KMT2B KMT2D	2.43e-04	5	93	2	PS51542
Domain	BRK	SMARCA4 CHD6	3.63e-04	6	93	2	SM00592
Domain	BRK_domain	SMARCA4 CHD6	3.63e-04	6	93	2	IPR006576
Domain	BRK	SMARCA4 CHD6	3.63e-04	6	93	2	PF07533
Domain	SET	KMT2B EZH2 KMT2D	1.11e-03	41	93	3	PF00856
Domain	PTBI	IRS4 DOK3	1.31e-03	11	93	2	SM00310
Domain	PNMA	PNMA8B PNMA3	1.31e-03	11	93	2	PF14893
Domain	PNMA	PNMA8B PNMA3	1.31e-03	11	93	2	IPR026523
Domain	SET	KMT2B EZH2 KMT2D	1.55e-03	46	93	3	SM00317
Domain	IRS_PTB	IRS4 DOK3	1.57e-03	12	93	2	PS51064
Domain	SET_dom	KMT2B EZH2 KMT2D	1.98e-03	50	93	3	IPR001214
Domain	SET	KMT2B EZH2 KMT2D	1.98e-03	50	93	3	PS50280
Domain	Helicase_C	SMARCA4 CHD6 POLQ DDX21	2.01e-03	107	93	4	PF00271
Domain	HELICc	SMARCA4 CHD6 POLQ DDX21	2.01e-03	107	93	4	SM00490
Domain	Helicase_C	SMARCA4 CHD6 POLQ DDX21	2.08e-03	108	93	4	IPR001650
Domain	IRS_PTB	IRS4 DOK3	2.15e-03	14	93	2	IPR002404
Domain	IRS	IRS4 DOK3	2.15e-03	14	93	2	PF02174
Domain	HELICASE_CTER	SMARCA4 CHD6 POLQ DDX21	2.15e-03	109	93	4	PS51194
Domain	HELICASE_ATP_BIND_1	SMARCA4 CHD6 POLQ DDX21	2.15e-03	109	93	4	PS51192
Domain	DEXDc	SMARCA4 CHD6 POLQ DDX21	2.15e-03	109	93	4	SM00487
Domain	Helicase_ATP-bd	SMARCA4 CHD6 POLQ DDX21	2.22e-03	110	93	4	IPR014001
Domain	Post-SET_dom	KMT2B KMT2D	2.81e-03	16	93	2	IPR003616
Domain	PostSET	KMT2B KMT2D	2.81e-03	16	93	2	SM00508
Domain	POST_SET	KMT2B KMT2D	2.81e-03	16	93	2	PS50868
Domain	EPHD	KMT2B KMT2D	5.31e-03	22	93	2	PS51805
Domain	Rho_GTPase_activation_prot	ARHGAP23 SYDE1 PLXNB1	9.67e-03	88	93	3	IPR008936
Pubmed	Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element.	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	2.79e-18	12	106	8	10433963
Pubmed	Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy.	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	7.23e-18	13	106	8	17668377
Pubmed	The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	1.59e-17	8	106	7	17588759
Pubmed	DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	2.38e-16	10	106	7	17984056
Pubmed	Characterization of a tandemly repeated 3.3-kb KpnI unit in the facioscapulohumeral muscular dystrophy (FSHD) gene region on chromosome 4q35.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	3.38e-15	13	106	7	7739628
Pubmed	Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	3.79e-14	17	106	7	11245978
Pubmed	The homeobox transcription factor DUXBL controls exit from totipotency.	DUX4L9 DUX4L2 DUX4L4	1.10e-07	4	106	3	38509386
Pubmed	Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development.	DUX4L9 DUX4L2 DUX4L4	1.10e-07	4	106	3	17911620
Pubmed	Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl.	DUX4L9 DUX4L2 DUX4L4	2.74e-07	5	106	3	20063414
Pubmed	The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.	DUX4L9 DUX4L2 DUX4L4	9.55e-07	7	106	3	30765463
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	PPFIBP2 HNRNPA3 RRP1 PNMA8B SART1 GXYLT2 CDK13 DDX21 SRRM2	1.72e-06	361	106	9	26167880
Pubmed	CCND2, CTNNB1, DDX3X, GLI2, SMARCA4, MYC, MYCN, PTCH1, TP53, and MLL2 gene variants and risk of childhood medulloblastoma.	PTCH1 KMT2D SMARCA4	3.25e-06	10	106	3	26290144
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	ACAP1 PPP1R12B HNRNPA3 RIOX1 ABT1 RRP1 SART1 MRPL15 KLF13 CDK13 SMARCA4 DDX21 SRRM2	6.57e-06	949	106	13	36574265
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	IRS4 GTPBP6 PPP1R12B KHDRBS2 BAG1 HNRNPA3 PSMD8 PRX SART1 CDK13 YLPM1 DDRGK1 CHD6 POLQ DDX21 ATPAF2	7.67e-06	1442	106	16	35575683
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	KMT2B EZH2 KMT2D EPC1 SMARCA4 CHD6	9.04e-06	157	106	6	30186101
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	KMT2B HNRNPA3 EZH2 RRP1 SART1 TFPT KMT2D KLF13 CDK13 EPC1 YLPM1 SMARCA4 CHD6 DDX21 SRRM2	9.08e-06	1294	106	15	30804502
Pubmed	Kabuki syndrome stem cell models reveal locus specificity of histone methyltransferase 2D (KMT2D/MLL4).	KMT2B KMT2D	9.20e-06	2	106	2	35640156
Pubmed	Comparison of methylation episignatures in KMT2B- and KMT2D-related human disorders.	KMT2B KMT2D	9.20e-06	2	106	2	35506254
Pubmed	Defective regulation of microRNA target genes in myoblasts from facioscapulohumeral dystrophy patients.	DUX4L9 DUX4	9.20e-06	2	106	2	24145033
Pubmed	Clinical impact of EZH2 and its antagonist SMARCA4 in ovarian cancer.	EZH2 SMARCA4	9.20e-06	2	106	2	33230143
Pubmed	Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice.	DUX4L9 DUX4L2 DUX4L4	1.22e-05	15	106	3	35727972
Pubmed	Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins.	DUX4L9 DUX4L2 DUX4L4	1.22e-05	15	106	3	30071041
Pubmed	Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models.	EZH2 SMARCA4	2.76e-05	3	106	2	28292935
Pubmed	Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction.	KMT2B KMT2D	2.76e-05	3	106	2	32544095
Pubmed	The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter.	KMT2B KMT2D	2.76e-05	3	106	2	23358417
Pubmed	Modulation of the endocrine transcriptional program by targeting histone modifiers of the H3K27me3 mark.	EZH2 NEUROG3	2.76e-05	3	106	2	29530603
Pubmed	Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma.	PTCH1 KMT2D	2.76e-05	3	106	2	22183980
Pubmed	TRIM37 interacts with EZH2 to epigenetically suppress PTCH1 and regulate stemness in glioma stem cells through sonic hedgehog pathway.	PTCH1 EZH2	2.76e-05	3	106	2	38884661
Pubmed	Expression of genes FOLR1, BAG1 and LAPTM4B in functioning and non-functioning pituitary adenomas.	LAPTM4B BAG1	2.76e-05	3	106	2	23023342
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SHROOM3 SPIRE2 KMT2B GTPBP6 ATG2A PTCH1 KMT2D PLEKHO2 CDK13 ANKRD34A LRP3 RIPOR1 ATPAF2	3.24e-05	1105	106	13	35748872
Pubmed	Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.	KMT2B KMT2D	5.50e-05	4	106	2	19221051
Pubmed	MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing.	KMT2B KMT2D	5.50e-05	4	106	2	20808952
Pubmed	Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.	KMT2B KMT2D	5.50e-05	4	106	2	23826075
Pubmed	Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation.	RIOX1 EZH2	5.50e-05	4	106	2	23160351
Pubmed	Arteries define the position of the thyroid gland during its developmental relocalisation.	FOXE1 PTCH1	5.50e-05	4	106	2	16968815
Pubmed	The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers.	EZH2 SMARCA4	5.50e-05	4	106	2	28262751
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2B KMT2D	5.50e-05	4	106	2	23129768
Pubmed	DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation.	DUX4L9 DUX4	5.50e-05	4	106	2	19829708
Pubmed	The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.	IRS4 PPP1R12B HNRNPA3 RRP1 SART1 DDX21 SRRM2	6.83e-05	328	106	7	23398456
Pubmed	Evolving Catalytic Properties of the MLL Family SET Domain.	KMT2B KMT2D	9.15e-05	5	106	2	26320581
Pubmed	RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy.	DUX4L2 DUX4	9.15e-05	5	106	2	19359275
Pubmed	MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.	KMT2B KMT2D	9.15e-05	5	106	2	28609655
Pubmed	Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog Pathway.	PTCH1 EZH2 SMARCA4	9.49e-05	29	106	3	26959361
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	KMT2B EZH2 SART1 KMT2D CDK13 YLPM1 SMARCA4 RIPOR1 DDX21 SRRM2	1.31e-04	774	106	10	15302935
Pubmed	Dynamics of genomic H3K27me3 domains and role of EZH2 during pancreatic endocrine specification.	EZH2 NEUROG3	1.37e-04	6	106	2	25107471
Pubmed	Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.	KMT2B KMT2D	1.37e-04	6	106	2	24176642
Pubmed	MLL associates specifically with a subset of transcriptionally active target genes.	KMT2B KMT2D	1.37e-04	6	106	2	16199523
Pubmed	A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner.	EZH2 EPC1	1.37e-04	6	106	2	15536069
Pubmed	Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.	KMT2B KMT2D	1.37e-04	6	106	2	17021013
Pubmed	The C-terminal cytoplasmic tail of hedgehog receptor Patched1 is a platform for E3 ubiquitin ligase complexes.	QPCTL KHDRBS2 PSMD8 PTCH1	1.43e-04	86	106	4	26885983
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	IRS4 KMT2B SART1 CDK13 YLPM1 SMARCA4 DDX21 SRRM2	1.65e-04	506	106	8	30890647
Pubmed	Evf2 lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling.	PTCH1 SMARCA4	1.91e-04	7	106	2	26138476
Pubmed	Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.	KMT2B KMT2D	1.91e-04	7	106	2	30604749
Pubmed	Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development.	KMT2B KMT2D	1.91e-04	7	106	2	16540515
Pubmed	Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95.	KMT2B KMT2D	1.91e-04	7	106	2	23995757
Pubmed	ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.	KMT2B KMT2D	1.91e-04	7	106	2	19556342
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	MAGI1 IRS4 HNRNPA3 SART1 SMARCA4 DDX21	2.00e-04	274	106	6	34244482
Pubmed	POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.	MAGI1 SHROOM3 PPFIBP2 PPP1R12B KHDRBS2 CHD6	2.12e-04	277	106	6	30745168
Pubmed	Lysine acetylation targets protein complexes and co-regulates major cellular functions.	DOK3 PLEKHO2 SRRM2	2.15e-04	38	106	3	19608861
Pubmed	Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.	CABLES2 SHROOM3 PARD6G CDK13 DDX21 SRRM2 MAST3	2.35e-04	401	106	7	25852190
Pubmed	The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling.	GDF15 PRLH	2.55e-04	8	106	2	32723474
Pubmed	A long noncoding RNA protects the heart from pathological hypertrophy.	EZH2 SMARCA4	2.55e-04	8	106	2	25119045
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2B KMT2D	2.55e-04	8	106	2	23130995
Pubmed	The epigenetic modifier PBRM1 restricts the basal activity of the innate immune system by repressing retinoic acid-inducible gene-I-like receptor signalling and is a potential prognostic biomarker for colon cancer.	EZH2 SMARCA4	2.55e-04	8	106	2	28940253
Pubmed	Characterization of hampin/MSL1 as a node in the nuclear interactome.	ECM2 RASSF1	2.55e-04	8	106	2	17335777
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2B KMT2D	2.55e-04	8	106	2	22266653
Pubmed	New insights into BS69 functions.	EZH2 SMARCA4	2.55e-04	8	106	2	16565076
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	KMT2B CDK13 EPC1 SMARCA4 SRRM2	2.71e-04	186	106	5	33637726
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	MAGI1 SHROOM3 PPFIBP2 SRRM2	2.75e-04	102	106	4	15778465
Pubmed	Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.	EPC1 SMARCA4 SRRM2	2.90e-04	42	106	3	35705031
Pubmed	Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.	PSMD8 SART1 SRRM2	3.11e-04	43	106	3	34672947
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2B KMT2D	3.27e-04	9	106	2	22665483
Pubmed	Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair.	SEMA4G PLXNB1	3.27e-04	9	106	2	25892012
Pubmed	An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth.	PTCH1 EZH2	3.27e-04	9	106	2	25370275
Pubmed	Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.	KMT2B KMT2D	3.27e-04	9	106	2	16951254
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	SHROOM3 IRS4 PPFIBP2 ATG2A PTCH1 PRX YLPM1	3.58e-04	430	106	7	35044719
Pubmed	A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation.	IRS4 RRP1 DDRGK1	4.05e-04	47	106	3	32160526
Pubmed	Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis.	HNRNPA3 RRP1	4.08e-04	10	106	2	35821088
Pubmed	EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis.	EZH2 SMARCA4	4.08e-04	10	106	2	35210568
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	DUX4L9 DUX4L2 DUX4L4	4.86e-04	50	106	3	31806660
Pubmed	RNF125 attenuates hepatocellular carcinoma progression by downregulating SRSF1-ERK pathway.	HNRNPA3 SRRM2	4.97e-04	11	106	2	37142680
Pubmed	14-3-3 epsilon dynamically interacts with key components of mitogen-activated protein kinase signal module for selective modulation of the TNF-alpha-induced time course-dependent NF-kappaB activity.	QPCTL HNRNPA3 DDX21	5.46e-04	52	106	3	20462248
Pubmed	PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.	IRS4 QPCTL HNRNPA3 SMARCA4 DDX21	5.49e-04	217	106	5	31685992
Pubmed	The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.	MAGI1 SHROOM3 HNRNPA3 SRRM2	5.95e-04	125	106	4	29467281
Pubmed	Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.	KMT2B KMT2D	5.95e-04	12	106	2	17707229
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2B KMT2D	5.95e-04	12	106	2	27563068
Pubmed	Interplay of BAF and MLL4 promotes cell type-specific enhancer activation.	KMT2D SMARCA4	5.95e-04	12	106	2	33712604
Pubmed	Lack of TCF2/vHNF1 in mice leads to pancreas agenesis.	PTCH1 NEUROG3	5.95e-04	12	106	2	15668393
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	ABT1 EZH2 KMT2D CDK13 SMARCA4 CHD6 HYDIN	6.00e-04	469	106	7	27634302
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	IRS4 KMT2B SART1 EPC1 SMARCA4 DDX21	6.18e-04	339	106	6	30415952
Pubmed	Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.	MAGI1 EZH2 RASSF1 MAST3	6.51e-04	128	106	4	25332235
Pubmed	The DNA sequence and comparative analysis of human chromosome 10.	CALHM3 SEMA4G TLX1NB EPC1 DDX21 UTF1	6.77e-04	345	106	6	15164054
Pubmed	An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration.	SEMA4G PLXNB1	7.02e-04	13	106	2	24572910
Pubmed	Mechanochemical control of epidermal stem cell divisions by B-plexins.	PTCH1 PLXNB1	7.02e-04	13	106	2	33637728
Pubmed	Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.	KMT2B KMT2D	7.02e-04	13	106	2	21502505
Pubmed	UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program.	EZH2 SMARCA4	7.02e-04	13	106	2	22192413
Pubmed	Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos.	FOXE1 ADRA2C	7.02e-04	13	106	2	22266179
Pubmed	New nomenclature for chromatin-modifying enzymes.	KMT2B EZH2 KMT2D	7.14e-04	57	106	3	18022353
Pubmed	The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function.	SMARCA4 NEUROG3	8.18e-04	14	106	2	31201281
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	HNRNPA3 ABT1 RRP1 SART1 MRPL15 CDK13 YLPM1 DDX21 SRRM2	8.26e-04	807	106	9	22681889
Cytoband	4q35.2	DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	4.43e-11	27	109	6	4q35.2
Cytoband	Ensembl 112 genes in cytogenetic band chr4q35	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	4.28e-10	117	109	8	chr4q35
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	KMT2B QPCTL PSMD8 GRIK5 PRX PNMA8B TFPT ZNF665 DEDD2 DACT3 LRP3	1.30e-04	1192	109	11	chr19q13
Cytoband	9q22.3	ECM2 PTCH1	3.63e-04	12	109	2	9q22.3
Cytoband	19q13.2	PSMD8 GRIK5 PRX DEDD2	6.52e-04	164	109	4	19q13.2
Cytoband	19q13.32	QPCTL PNMA8B DACT3	7.47e-04	74	109	3	19q13.32
Cytoband	Ensembl 112 genes in cytogenetic band chr9q22	FOXE1 ECM2 PTCH1 ERCC6L2-AS1	1.36e-03	200	109	4	chr9q22
Cytoband	18q23	PARD6G KCNG2	2.17e-03	29	109	2	18q23
GeneFamily	PRD class homeoboxes and pseudogenes	DUX4L9 DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	3.84e-08	92	65	7	521
GeneFamily	PDZ domain containing	MAGI1 SHROOM3 ARHGAP23 PARD6G PRX MAST3	1.76e-05	152	65	6	1220
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2B EZH2 KMT2D	2.45e-04	34	65	3	487
GeneFamily	Paraneoplastic Ma antigens	PNMA8B PNMA3	6.85e-04	11	65	2	671
GeneFamily	Low density lipoprotein receptors	LRP10 LRP3	9.68e-04	13	65	2	634
GeneFamily	Ataxins\|Trinucleotide repeat containing	MAGI1 KMT2D	3.62e-03	25	65	2	775
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PPP1R12B YLPM1 PPP1R35 HYDIN	4.09e-03	181	65	4	694
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-late_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN GTPBP6 ECM2 PARD6G SYDE1 PHKA1	2.24e-06	165	102	6	0edd56e8d14eaeced9882dd9206ea93e8f402e8d
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN GTPBP6 ECM2 PARD6G SYDE1 PHKA1	2.24e-06	165	102	6	fa3aadfff6fb1e7f142db333c60c2cba02b17e6c
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KMT2B ECM2 ABT1 PLEKHO2 ZFTA POLQ	3.46e-06	178	102	6	c87945146b2734141f07b39d268e0d8086ee0364
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-matrix_-_immature_1\|E16.5-samps / Age Group, Lineage, Cell class and subclass	PRX PNMA8B LRP10 ZFR2 FBXO33	7.13e-06	116	102	5	f32f7eddfe33adb3b5cf7c34667a481a305c5163
Disease	pancreatitis, response to thiopurine	PTCH1 ERCC6L2-AS1	6.39e-05	4	97	2	EFO_0000278, EFO_0006317
Disease	prostate cancer (is_marker_for)	KMT2B EZH2 KMT2D CDK13 SMARCA4	1.69e-04	156	97	5	DOID:10283 (is_marker_for)
Disease	colorectal adenocarcinoma (is_implicated_in)	KMT2B DOK3 EZH2	2.09e-04	35	97	3	DOID:0050861 (is_implicated_in)
Disease	pseudouridine measurement	SHROOM3 GRIK5	2.96e-04	8	97	2	EFO_0021126
Disease	thyroid gland papillary carcinoma (is_implicated_in)	FOXE1 KMT2D	4.73e-04	10	97	2	DOID:3969 (is_implicated_in)
Disease	inflammatory biomarker measurement, YKL40 measurement	CYP27B1 PTCH1 ERCC6L2-AS1	6.40e-04	51	97	3	EFO_0004869, EFO_0004872
Disease	Lymphoma, Large-Cell, Follicular	EZH2 KMT2D	1.09e-03	15	97	2	C0079745
Disease	Lymphoma, Small Cleaved-Cell, Follicular	EZH2 KMT2D	1.09e-03	15	97	2	C0079765
Disease	Lymphoma, Mixed-Cell, Follicular	EZH2 KMT2D	1.09e-03	15	97	2	C0079758
Disease	Lymphoma, Follicular, Grade 2	EZH2 KMT2D	1.09e-03	15	97	2	C1956132
Disease	Lymphoma, Follicular, Grade 3	EZH2 KMT2D	1.09e-03	15	97	2	C1956131
Disease	Lymphoma, Follicular, Grade 1	EZH2 KMT2D	1.09e-03	15	97	2	C1956130
Disease	skin pigmentation measurement	SPIRE2 PTCH1 HYDIN ERCC6L2-AS1	1.10e-03	137	97	4	EFO_0007009
Disease	Schizoaffective disorder-bipolar type	PTCH1 ERCC6L2-AS1	1.25e-03	16	97	2	EFO_0009965
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	KMT2B SRRM2	1.41e-03	17	97	2	DOID:0060307 (is_implicated_in)
Disease	congenital heart disease (implicated_via_orthology)	KMT2B KMT2D CHD6	1.54e-03	69	97	3	DOID:1682 (implicated_via_orthology)
Disease	chemerin measurement	PTCH1 ERCC6L2-AS1	1.76e-03	19	97	2	EFO_0004573
Disease	esophagus squamous cell carcinoma (is_marker_for)	PTCH1 EZH2 KMT2D	1.89e-03	74	97	3	DOID:3748 (is_marker_for)
Disease	renal system measurement	SHROOM3 GRIK5	1.96e-03	20	97	2	EFO_0004742
Disease	colorectal adenoma (is_marker_for)	PTCH1 EZH2	1.96e-03	20	97	2	DOID:0050860 (is_marker_for)
Disease	Lymphoma, Follicular	EZH2 KMT2D	1.96e-03	20	97	2	C0024301
Disease	osteoarthritis, hip, osteoarthritis, knee, total joint arthroplasty	PTCH1 ERCC6L2-AS1	2.16e-03	21	97	2	EFO_0004616, EFO_0010726, EFO_1000786
Disease	risky sexual behaviour measurement	GRIK5 KCNG2 FBXO33 MAST3	2.38e-03	169	97	4	EFO_0007877
Disease	infant body height	PTCH1 ERCC6L2-AS1	2.59e-03	23	97	2	EFO_0006785
Disease	lung squamous cell carcinoma (is_implicated_in)	PTCH1 KMT2D	2.82e-03	24	97	2	DOID:3907 (is_implicated_in)
Disease	hepatocellular carcinoma (is_implicated_in)	KMT2B EZH2 CDK13 SMARCA4	3.05e-03	181	97	4	DOID:684 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LRRGTGRRRDPGPQS	FAM246C	21	P0DSO1
RRRVGRGGRVLLDRA	EPC1	456	Q9H2F5
RRTGRPFGGLIRDVR	SLC4A2	676	P04920
ERGSGRRSPLREARR	BRWD1-AS2	66	P59051
GRTLLAARGPERRRA	CCR10	231	P46092
LPAEARGRGRRRRLV	DUX4L4	11	P0CJ87
AAERRRRRGALRRGG	ADRA2C	291	P18825
ARGLRRGNAGRRLEL	CALHM3	256	Q86XJ0
GARRPRGDRERLGSR	BAG1	6	Q99933
QGGRRKFRRQRPRLS	APLN	56	Q9ULZ1
TKLPEIRGRRGGRGR	ACAP1	521	Q15027
RQRRSRGRPSGGARR	DEDD2	156	Q8WXF8
LPAEARGRGRRRRLV	DUX4L6	11	P0CJ89
AESSLLRRGPRGRGR	C1orf115	11	Q9H7X2
KRRAGGRQKRRRGPR	CDK13	96	Q14004
GTQRRGEGSERRPRR	CDK13	186	Q14004
EEPRAGGRPRRRRDL	DDRGK1	56	Q96HY6
GGRPRRRRDLGSRLQ	DDRGK1	61	Q96HY6
RRLRRGQQPADLREG	ATG2A	1836	Q2TAZ0
RLTRGRRRGDRELGI	ARMC10	26	Q8N2F6
LGGRRRGGALQRREV	ABHD15	436	Q6UXT9
GRRRSPGLLERRGSG	ANKRD34A	396	Q69YU3
DARRGPGRGTSVRRR	RASSF1	191	Q9NS23
RGRPRLRLGERGLME	QPCTL	6	Q9NXS2
VRRLRRQRGRGTGPP	CYP27B1	166	O15528
GGGRTRREAPRELRL	DCHS1	2886	Q96JQ0
GPGARRRQRGRLMRR	LRP10	541	Q7Z4F1
RSPERRRGGSPERRA	MAGI1	1411	Q96QZ7
LRLRDGGRRLLNRPA	ATPAF2	6	Q8N5M1
LPAEARGRGRRRRLV	DUX4	11	Q9UBX2
EPRRGKARRSPGRRR	PSMG3-AS1	136	Q96PY0
GAPRKLRARRGGRSR	NEUROG3	56	Q9Y4Z2
GLRLSRVGRGRSAPR	GTPBP6	11	O43824
RRRRLDGALNRVPVG	PHKA1	1056	P46020
GRRDREVGRGLRAPA	C20orf203	116	Q8NBC4
RRLRGLLRVLRGRPG	FBXO33	36	Q7Z6M2
LLRVLRGRPGAGSRR	FBXO33	41	Q7Z6M2
LPAEARGRGRRRRLV	DUX4L3	11	P0CJ86
GGRRRGRLPNNSSRP	EZH2	351	Q15910
PRPRRGSLRGGERER	PLXNB1	1896	O43157
PARALGPRGRLQRGR	KCNG2	146	Q9UJ96
GPRGRLQRGRRRLRD	KCNG2	151	Q9UJ96
RPRAGRRGAARLEKL	GXYLT2	76	A0PJZ3
RRGAARLEKLARRPG	GXYLT2	81	A0PJZ3
GRAGREPERRRSRQQ	LAPTM4B	51	Q86VI4
EPERRRSRQQRRGGL	LAPTM4B	56	Q86VI4
RRHASRRGPSRRRLG	LRP3	591	O75074
SAGPGRRGERRVIRL	DOK3	116	Q7L591
PQAARGRRRARARNG	GDF15	186	Q99988
LRSQRGRAPRGRGRK	KMT2B	141	Q9UMN6
RRLASPRGGRRPKRI	KBTBD7	11	Q8WVZ9
RRGGLRATAGPRLSR	PPFIBP2	526	Q8ND30
RALGALRDEGPRRRA	PARD6G	116	Q9BYG4
RLLRRQRAGGRPSRP	GID4	31	Q8IVV7
RVDGRRPIGARARRI	FCSK	741	Q8N0W3
RARKAARPGGRERAR	ABT1	221	Q9ULW3
PLGGRRGRKDRERER	HYDIN	2501	Q4G0P3
LLRRRRRRGAGQPRT	DACT3	256	Q96B18
EPILRDTGPRRRGRR	CHD6	2431	Q8TD26
DTGPRRRGRRPRSEL	CHD6	2436	Q8TD26
LGLRRRRRRTGGRQG	ERCC6L2-AS1	66	Q8WZB0
TRRGIDNGRKLRLGR	POLQ	2161	O75417
LPAEARGRGRRRRLV	DUX4L9	11	Q6RFH8
LPAEARGRGRRRRLV	DUX4L7	11	P0CJ90
RGGDRKQRPGEERRL	ECM2	246	O94769
LSLPRRGRGCRSGNR	MAST3	16	O60307
RGRGIRGRGIRIAPT	KHDRBS2	186	Q5VWX1
GSGEPGLRQRVRRGR	KLF13	141	Q9Y2Y9
NRRFRGQREGSRGPR	DDX21	741	Q9NR30
LPAEARGRGRRRRLV	DUX4L5	11	P0CJ88
SRRRRRPGGPSRALL	GRIK5	861	Q16478
APPQALRRRGDSRRR	CABLES2	31	Q9BTV7
RGRLHLPRGRRSRRA	IRS4	411	O14654
ENGNYRRRRRRRGPK	FOXL3	121	A0A1W2PRP0
LRRRLSLRGPRAGRE	SYDE1	176	Q6ZW31
PERRPRGRRRGRKCG	MRPL15	36	Q9P015
RNLSLVRGRRGERPD	SRRM2	21	Q9UQ35
PEGRVSRLGRRLGRR	TMEM200B	16	Q69YZ2
SRLGRRLGRRRRPRS	TMEM200B	21	Q69YZ2
LFQRRRRGRGGRVTF	TGFBR3L	11	H3BV60
TGRGAGGRRRKRPLQ	FOXE1	36	O00358
LGAARNPRRGRRGRR	PNMA8B	151	Q9ULN7
DARPSQGYRRRRGRG	PNMA3	376	Q9UL41
GRRKGRAERRGAARQ	PPP1R35	61	Q8TAP8
GRRRRTGGLRRAAAP	PTCH1	31	Q13635
QDRLKGGRRRPSRGS	SMARCA4	1606	P51532
NRLQRRRARRGGGSG	SPPL2C	211	Q8IUH8
GGRRLGERRRGDLLS	SHROOM3	1176	Q8TF72
AERRRRRRGAQRGAG	SPNS2	21	Q8IVW8
QPRGRGQRGARQRRR	RRP1	421	P56182
GQRGARQRRRTPRPL	RRP1	426	P56182
ARRFVGPRVQRLRRG	RDH14	21	Q9HBH5
ASAGPLRRGRPKRRR	RIOX1	6	Q9H6W3
PGRRAQRDRRAAGNR	ZNF665	121	Q9H7R5
LRRTLRNLGGGRGQR	TLX1NB	106	P0CAT3
RRRLATLGGRERPGA	TEX22	71	C9J3V5
RLGARFRKRQRGPGE	ZFR2	906	Q9UPR6
LREGRRGRRRKYSLG	SEMA4G	701	Q9NTN9
GPSGRKRRRVPRDGR	TFPT	186	P0C1Z6
KRRRVPRDGRRAGNA	TFPT	191	P0C1Z6
QGCRGLRGSPGRRLR	SPIRE2	46	Q8WWL2
DTLARRRLARGRPDG	ARHGAP23	1316	Q9P227
GASGRRGRVRVRLPR	PRX	1366	Q9BXM0
GIRPVGRFGRRRATL	PRLH	46	P81277
QPDSGRRRRRRGEEG	HNRNPA3	11	P51991
GSRLRGRGRRRVSEV	SART1	436	O43290
RRAGSRERIPPRRAG	YLPM1	1126	P49750
RERIPPRRAGSRERG	YLPM1	1131	P49750
LGPARRGRRRTRAAG	ZPBP	6	Q9BS86
RGDRRDPGDRRRFGR	VXN	61	Q8TAG6
TRDRVRGGQRRRPPT	PLEKHO2	141	Q8TD55
PPRERRRATRGGLRQ	PSMD8	11	P48556
LRLAPEGRLRRDGLR	RIPOR1	1086	Q6ZS17
RRGRRRGGRALARPR	TMEM271	251	A0A286YF58
RAQPPASRARRGRRG	TMEM271	271	A0A286YF58
RGRRGRRGRRLQQRP	TMEM271	281	A0A286YF58
GGSRGLGARRLERRL	ZFTA	246	C9JLR9
LLGDNGRKRPRRRSP	UTF1	146	Q5T230
RRRSPGSGRPQRARR	UTF1	156	Q5T230
RPRGLRGPLRGRLRQ	ZAN	2621	Q9Y493
LPAEARGRGRRRRLV	DUX4L2	11	P0CJ85
RRQRRGRLGLPGEAG	KMT2D	1611	O14686
RERRRPKERRRGTGI	PPP1R12B	796	O60237