Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein-cysteine S-palmitoyltransferase activity

ZDHHC20 ZDHHC9 ZDHHC5 ZDHHC8

1.12e-0626614GO:0019706
GeneOntologyMolecularFunctionprotein-cysteine S-acyltransferase activity

ZDHHC20 ZDHHC9 ZDHHC5 ZDHHC8

1.12e-0626614GO:0019707
GeneOntologyMolecularFunctionS-acyltransferase activity

ZDHHC20 ZDHHC9 ZDHHC5 ZDHHC8

2.04e-0630614GO:0016417
GeneOntologyMolecularFunctionpalmitoyltransferase activity

ZDHHC20 ZDHHC9 ZDHHC5 ZDHHC8

4.83e-0637614GO:0016409
GeneOntologyMolecularFunctionacyltransferase activity

ZDHHC20 TRAF3 TRIM25 RNF31 TRIM61 RBBP6 ZDHHC9 NFX1 ZDHHC5 RNF41 ZDHHC8

1.99e-057756111GO:0016746
GeneOntologyMolecularFunctionzinc ion binding

ZCCHC4 ZDHHC20 TRAF3 RNF31 TRIM61 RBBP6 ZNF330 NFX1 PRICKLE2 RNF41 CHD3

7.09e-058916111GO:0008270
GeneOntologyMolecularFunctionubiquitin protein ligase activity

TRAF3 TRIM25 RNF31 TRIM61 RBBP6 NFX1 RNF41

1.35e-04372617GO:0061630
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

TRAF3 TRIM25 RNF31 TRIM61 RBBP6 NFX1 RNF41

2.05e-04398617GO:0061659
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

TRAF3 TRIM25 RNF31 TRIM61 RBBP6 NFX1 RNF41

5.79e-04473617GO:0004842
GeneOntologyMolecularFunctiontransition metal ion binding

ZCCHC4 ZDHHC20 TRAF3 RNF31 TRIM61 RBBP6 ZNF330 NFX1 PRICKLE2 RNF41 CHD3

8.51e-0411896111GO:0046914
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

TRAF3 TRIM25 RNF31 TRIM61 RBBP6 NFX1 RNF41

9.22e-04512617GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

TRAF3 TRIM25 RNF31 TRIM61 RBBP6 NFX1 RNF41

1.15e-03532617GO:0016755
GeneOntologyMolecularFunctioncalcium ion binding

HSPG2 FBLN1 MEGF8 SLIT3 TENM2 FBN3 NOTCH2 NOTCH4

1.92e-03749618GO:0005509
GeneOntologyMolecularFunctionextracellular matrix structural constituent

HSPG2 FBLN1 FRAS1 FBN3

2.61e-03188614GO:0005201
GeneOntologyMolecularFunctiontransmembrane receptor protein serine/threonine kinase binding

ELAPOR2 SMAD7

3.07e-0327612GO:0070696
GeneOntologyBiologicalProcessprotein palmitoylation

ZDHHC20 ZDHHC9 ZDHHC5 ZDHHC8

2.84e-0633624GO:0018345
GeneOntologyBiologicalProcessaxon guidance

HSPG2 MEGF8 DRAXIN SLIT3 LAMC3 TENM2 NOTCH2

2.29e-05285627GO:0007411
GeneOntologyBiologicalProcessneuron projection guidance

HSPG2 MEGF8 DRAXIN SLIT3 LAMC3 TENM2 NOTCH2

2.35e-05286627GO:0097485
GeneOntologyBiologicalProcesspositive regulation by host of viral process

ZDHHC20 ZDHHC9 ZDHHC8

4.39e-0523623GO:0044794
GeneOntologyBiologicalProcessresponse to BMP

ADAMTS12 ELAPOR2 MEGF8 NBL1 NOTCH2 SMAD7

4.52e-05215626GO:0071772
GeneOntologyBiologicalProcesscellular response to BMP stimulus

ADAMTS12 ELAPOR2 MEGF8 NBL1 NOTCH2 SMAD7

4.52e-05215626GO:0071773
GeneOntologyBiologicalProcesspeptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine

ZDHHC20 ZDHHC9 ZDHHC8

5.00e-0524623GO:0018231
GeneOntologyBiologicalProcesspeptidyl-L-cysteine S-palmitoylation

ZDHHC20 ZDHHC9 ZDHHC8

5.00e-0524623GO:0018230
GeneOntologyBiologicalProcesslipoprotein metabolic process

ZDHHC20 ZDHHC9 ZDHHC5 ZDHHC8 PCSK9

8.01e-05147625GO:0042157
GeneOntologyBiologicalProcessaxon development

HSPG2 MEGF8 DRAXIN SLIT3 LAMC3 GRN TENM2 ADCY1 NOTCH2

1.21e-04642629GO:0061564
GeneOntologyBiologicalProcessartery morphogenesis

MEGF8 ADGRF5 NOTCH4 SMAD7

1.70e-0492624GO:0048844
GeneOntologyBiologicalProcessembryo implantation

PCSK5 HSPG2 FBLN1 GRN

2.08e-0497624GO:0007566
GeneOntologyBiologicalProcessmaintenance of synapse structure

SHANK2 PRICKLE2 GRN

2.36e-0440623GO:0099558
GeneOntologyBiologicalProcessprotein lipidation

ZDHHC20 ZDHHC9 ZDHHC5 ZDHHC8

2.43e-04101624GO:0006497
GeneOntologyBiologicalProcessaxonogenesis

HSPG2 MEGF8 DRAXIN SLIT3 LAMC3 TENM2 ADCY1 NOTCH2

2.81e-04566628GO:0007409
GeneOntologyBiologicalProcesslipoprotein biosynthetic process

ZDHHC20 ZDHHC9 ZDHHC5 ZDHHC8

2.92e-04106624GO:0042158
GeneOntologyBiologicalProcessprotein acylation

ZDHHC20 ZDHHC9 ZDHHC5 ZDHHC8

3.14e-04108624GO:0043543
GeneOntologyBiologicalProcessBMP signaling pathway

ELAPOR2 MEGF8 NBL1 NOTCH2 SMAD7

3.14e-04197625GO:0030509
GeneOntologyBiologicalProcesspositive regulation of pyroptotic inflammatory response

ZDHHC9 ZDHHC5

3.16e-049622GO:0140639
GeneOntologyBiologicalProcessmaintenance of postsynaptic density structure

SHANK2 PRICKLE2

3.16e-049622GO:0099562
GeneOntologyBiologicalProcessblood vessel development

PCSK5 HSPG2 MEGF8 PDGFD ADGRF5 GRN MYO18B NOTCH2 NOTCH4 SMAD7

4.18e-049296210GO:0001568
GeneOntologyBiologicalProcesspeptidyl-cysteine modification

ZDHHC20 ZDHHC9 ZDHHC8

4.58e-0450623GO:0018198
GeneOntologyBiologicalProcessmodulation by host of viral process

ZDHHC20 ZDHHC9 ZDHHC8

5.15e-0452623GO:0044788
GeneOntologyBiologicalProcessvasculature development

PCSK5 HSPG2 MEGF8 PDGFD ADGRF5 GRN MYO18B NOTCH2 NOTCH4 SMAD7

5.82e-049696210GO:0001944
GeneOntologyBiologicalProcessneuron projection morphogenesis

HSPG2 MEGF8 DRAXIN SLIT3 NBL1 LAMC3 TENM2 ADCY1 NOTCH2

6.21e-04802629GO:0048812
GeneOntologyBiologicalProcessregulation of BMP signaling pathway

ELAPOR2 NBL1 NOTCH2 SMAD7

6.52e-04131624GO:0030510
GeneOntologyBiologicalProcessprotein ubiquitination

TRAF3 TRIM25 RNF31 MEGF8 TRIM61 RBBP6 NFX1 RNF41 SMAD7

6.72e-04811629GO:0016567
GeneOntologyBiologicalProcesspharyngeal arch artery morphogenesis

MEGF8 ADGRF5

6.79e-0413622GO:0061626
GeneOntologyBiologicalProcessartery development

MEGF8 ADGRF5 NOTCH4 SMAD7

6.90e-04133624GO:0060840
GeneOntologyBiologicalProcesscardiac septum development

PCSK5 SLIT3 NOTCH2 SMAD7

7.10e-04134624GO:0003279
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

HSPG2 MEGF8 DRAXIN SLIT3 NBL1 LAMC3 TENM2 ADCY1 NOTCH2

7.21e-04819629GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

HSPG2 MEGF8 DRAXIN SLIT3 NBL1 LAMC3 TENM2 ADCY1 NOTCH2

7.66e-04826629GO:0048858
GeneOntologyBiologicalProcesscell morphogenesis

HSPG2 MEGF8 DRAXIN SLIT3 NBL1 LAMC3 FGD6 TENM2 ADCY1 NOTCH2 NOTCH4

7.78e-0411946211GO:0000902
GeneOntologyBiologicalProcesskidney development

PCSK5 FRAS1 PDGFD NOTCH2 PCSK9 SMAD7

8.68e-04372626GO:0001822
GeneOntologyBiologicalProcessfemale pregnancy

PCSK5 HSPG2 FBLN1 CORIN GRN

9.10e-04249625GO:0007565
GeneOntologyCellularComponentGolgi membrane

PCSK5 ZDHHC20 ZDHHC9 PDGFD ZDHHC5 GALNT12 ZDHHC8 NOTCH2 NOTCH4

2.94e-04721639GO:0000139
GeneOntologyCellularComponentCD40 receptor complex

TRAF3 RNF31

4.83e-0411632GO:0035631
GeneOntologyCellularComponentbasement membrane

HSPG2 FBLN1 FRAS1 LAMC3

5.04e-04122634GO:0005604
MousePhenotransposition of great arteries

PCSK5 HSPG2 MEGF8 SMAD7

2.50e-0547514MP:0004110
MousePhenoabnormal heart and great artery attachment

PCSK5 HSPG2 FBLN1 MEGF8 SLIT3 SMAD7

9.61e-05205516MP:0010426
MousePhenoabnormal heart and great vessel attachment

PCSK5 HSPG2 FBLN1 MEGF8 SLIT3 SMAD7

1.04e-04208516MP:0010425
MousePhenoabnormal myocardium layer morphology

HSPG2 FBLN1 MEGF8 SLIT3 CTNNA3 MYO18B NOTCH2 SMAD7

1.15e-04414518MP:0005329
MousePhenoneural tube degeneration

PTPN12 REV3L

1.30e-045512MP:0012509
MousePhenoabnormal heart layer morphology

HSPG2 FBLN1 MEGF8 SLIT3 CTNNA3 MYO18B NOTCH2 SMAD7

1.32e-04422518MP:0010545
MousePhenoabnormal blood vessel morphology

ADAMTS12 PCSK5 HSPG2 FBLN1 FRAS1 PTPN12 MEGF8 PDGFD SLIT3 ZDHHC5 REV3L MYO18B NOTCH2 NOTCH4 SMAD7

1.64e-0414725115MP:0001614
DomainGrowth_fac_rcpt_

PCSK5 HSPG2 ELAPOR2 FBLN1 FRAS1 MEGF8 SCARF2 SLIT3 LAMC3 FBN3 NOTCH2 NOTCH4

1.39e-131566312IPR009030
DomainEGF

PCSK5 HSPG2 FBLN1 FRAS1 MEGF8 SCARF2 SLIT3 LAMC3 TENM2 FBN3 NOTCH2 NOTCH4 PEAR1

8.52e-132356313SM00181
DomainEGF-like_dom

PCSK5 HSPG2 FBLN1 FRAS1 MEGF8 SCARF2 SLIT3 LAMC3 TENM2 FBN3 NOTCH2 NOTCH4 PEAR1

1.78e-122496313IPR000742
DomainEGF_1

HSPG2 FBLN1 MEGF8 SCARF2 SLIT3 LAMC3 TENM2 FBN3 NOTCH2 NOTCH4 PEAR1

8.15e-102556311PS00022
DomainEGF-like_CS

HSPG2 FBLN1 MEGF8 SCARF2 SLIT3 LAMC3 TENM2 FBN3 NOTCH2 NOTCH4 PEAR1

1.04e-092616311IPR013032
DomainEGF_2

HSPG2 FBLN1 MEGF8 SCARF2 SLIT3 LAMC3 TENM2 FBN3 NOTCH2 NOTCH4 PEAR1

1.22e-092656311PS01186
DomainEGF_3

HSPG2 FBLN1 MEGF8 SCARF2 SLIT3 TENM2 FBN3 NOTCH2 NOTCH4 PEAR1

5.86e-092356310PS50026
DomainEGF_CA

HSPG2 FBLN1 MEGF8 SLIT3 TENM2 FBN3 NOTCH2 NOTCH4

7.54e-09122638SM00179
DomainEGF-like_Ca-bd_dom

HSPG2 FBLN1 MEGF8 SLIT3 TENM2 FBN3 NOTCH2 NOTCH4

8.58e-09124638IPR001881
DomainDHHC

ZCCHC4 ZDHHC20 ZDHHC9 ZDHHC5 ZDHHC8

1.87e-0825635PS50216
DomainZnf_DHHC_palmitoyltrfase

ZCCHC4 ZDHHC20 ZDHHC9 ZDHHC5 ZDHHC8

1.87e-0825635IPR001594
DomainLaminin_EGF

HSPG2 MEGF8 SCARF2 LAMC3 PEAR1

1.12e-0735635PF00053
DomainEGF_Lam

HSPG2 MEGF8 SCARF2 LAMC3 PEAR1

1.12e-0735635SM00180
DomainLaminin_EGF

HSPG2 MEGF8 SCARF2 LAMC3 PEAR1

1.71e-0738635IPR002049
DomainEGF_Ca-bd_CS

FBLN1 MEGF8 SLIT3 FBN3 NOTCH2 NOTCH4

8.98e-0797636IPR018097
Domainzf-DHHC

ZDHHC20 ZDHHC9 ZDHHC5 ZDHHC8

9.92e-0723634PF01529
DomainEGF_CA

FBLN1 MEGF8 SLIT3 FBN3 NOTCH2 NOTCH4

1.01e-0699636PS01187
DomainEGF-type_Asp/Asn_hydroxyl_site

FBLN1 MEGF8 SLIT3 FBN3 NOTCH2 NOTCH4

1.51e-06106636IPR000152
DomainRING

TRAF3 TRIM25 RNF31 TRIM61 RBBP6 NFX1 RNF41 CHD3

8.19e-06305638SM00184
DomainEGF_CA

FBLN1 MEGF8 FBN3 NOTCH2 NOTCH4

1.05e-0586635PF07645
DomainZnf_RING

TRAF3 TRIM25 RNF31 TRIM61 RBBP6 NFX1 RNF41 CHD3

1.33e-05326638IPR001841
DomainASX_HYDROXYL

FBLN1 MEGF8 FBN3 NOTCH2 NOTCH4

2.19e-05100635PS00010
DomainLUC7

LUC7L LUC7L2

3.35e-053632PF03194
DomainLuc7-rel

LUC7L LUC7L2

3.35e-053632IPR004882
DomainZF_RING_1

TRAF3 TRIM25 RNF31 TRIM61 RBBP6 NFX1 RNF41

5.44e-05291637PS00518
DomainZF_RING_2

TRAF3 TRIM25 RNF31 TRIM61 RBBP6 NFX1 RNF41

6.32e-05298637PS50089
DomainEGF

HSPG2 SLIT3 FBN3 NOTCH2 NOTCH4

6.63e-05126635PF00008
DomainNotch

NOTCH2 NOTCH4

6.69e-054632IPR008297
DomainNODP

NOTCH2 NOTCH4

6.69e-054632PF07684
DomainNotch_NODP_dom

NOTCH2 NOTCH4

6.69e-054632IPR011656
DomainNotch_NOD_dom

NOTCH2 NOTCH4

6.69e-054632IPR010660
DomainNOD

NOTCH2 NOTCH4

6.69e-054632PF06816
DomainNOD

NOTCH2 NOTCH4

6.69e-054632SM01338
DomainNODP

NOTCH2 NOTCH4

6.69e-054632SM01339
DomainLNR

NOTCH2 NOTCH4

1.11e-045632PS50258
DomainhEGF

FBN3 NOTCH2 NOTCH4

1.13e-0428633PF12661
Domain-

TRAF3 TRIM25 TRIM61 RBBP6 ZFYVE26 RNF41 CHD3 FGD6

1.27e-044496383.30.40.10
DomainEGF_LAM_2

HSPG2 MEGF8 LAMC3

1.39e-0430633PS50027
DomainEGF_LAM_1

HSPG2 MEGF8 LAMC3

1.39e-0430633PS01248
DomainZnf_RING/FYVE/PHD

TRAF3 TRIM25 TRIM61 RBBP6 ZFYVE26 RNF41 CHD3 FGD6

1.48e-04459638IPR013083
DomainZnf_RING_CS

TRAF3 TRIM25 RNF31 TRIM61 RNF41

2.22e-04163635IPR017907
DomainNotch_dom

NOTCH2 NOTCH4

2.33e-047632IPR000800
DomainNotch

NOTCH2 NOTCH4

2.33e-047632PF00066
DomainNL

NOTCH2 NOTCH4

2.33e-047632SM00004
DomainLAMININ_IVA

HSPG2 LAMC3

3.09e-048632PS51115
DomainLaminin_B

HSPG2 LAMC3

3.09e-048632PF00052
DomainLamB

HSPG2 LAMC3

3.09e-048632SM00281
DomainLaminin_IV

HSPG2 LAMC3

3.09e-048632IPR000034
DomainPeptidase_S8_subtilisin-rel

PCSK5 PCSK9

4.95e-0410632IPR015500
DomainSUBTILASE_ASP

PCSK5 PCSK9

4.95e-0410632PS00136
DomainSUBTILASE_HIS

PCSK5 PCSK9

4.95e-0410632PS00137
DomainSUBTILASE_SER

PCSK5 PCSK9

4.95e-0410632PS00138
Domain-

PCSK5 PCSK9

6.04e-04116323.40.50.200
DomainPeptidase_S8/S53_dom

PCSK5 PCSK9

6.04e-0411632IPR000209
DomainPeptidase_S8

PCSK5 PCSK9

6.04e-0411632PF00082
DomainSEA

HSPG2 ADGRF5

9.93e-0414632SM00200
Domain-

TRAF3 RNF41

9.93e-04146323.90.890.10
DomainSIAH-type

TRAF3 RNF41

1.30e-0316632IPR013323
DomainPropept_inh

PCSK5 PCSK9

1.47e-0317632IPR009020
DomainFurin_repeat

PCSK5 FRAS1

1.65e-0318632IPR006212
DomainFU

PCSK5 FRAS1

1.65e-0318632SM00261
DomainPLAC

ADAMTS12 PCSK5

1.85e-0319632PS50900
DomainPLAC

ADAMTS12 PCSK5

1.85e-0319632IPR010909
DomainSEA

HSPG2 ADGRF5

2.48e-0322632PF01390
DomainCT

SLIT3 NBL1

2.48e-0322632SM00041
DomainSEA

HSPG2 ADGRF5

2.71e-0323632PS50024
DomainSEA_dom

HSPG2 ADGRF5

2.71e-0323632IPR000082
DomainTRAF-like

TRAF3 RNF41

2.95e-0324632IPR008974
DomainEphrin_rec_like

PCSK5 ELAPOR2

3.20e-0325632SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

PCSK5 ELAPOR2

3.20e-0325632IPR011641
DomainCys_knot_C

SLIT3 NBL1

3.20e-0325632IPR006207
DomainCTCK_2

SLIT3 NBL1

3.20e-0325632PS01225
PathwayREACTOME_MATURATION_OF_SPIKE_PROTEIN

ZDHHC20 ZDHHC9 ZDHHC5 ZDHHC8

6.06e-0637464M41728
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382

NFX1 NOTCH2 NOTCH4

9.09e-0613463M47534
PathwayREACTOME_TRANSLATION_OF_SARS_COV_2_STRUCTURAL_PROTEINS

ZDHHC20 ZDHHC9 ZDHHC5 ZDHHC8

3.45e-0557464M41730
PathwayREACTOME_SARS_COV_2_INFECTION

ZDHHC20 HSPG2 TRAF3 TRIM25 ZDHHC9 ZDHHC5 ZDHHC8

4.74e-05299467M41727
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS12 GALNT12 NOTCH2 NOTCH4

6.94e-0568464M27303
PathwayREACTOME_LATE_SARS_COV_2_INFECTION_EVENTS

ZDHHC20 ZDHHC9 ZDHHC5 ZDHHC8

7.77e-0570464M46438
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS12 HSPG2 GALNT12 NOTCH2 NOTCH4

9.82e-05143465M27275
PathwayREACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3

NOTCH2 NOTCH4

1.04e-045462M27411
PathwayREACTOME_SARS_COV_INFECTIONS

ZDHHC20 HSPG2 TRAF3 TRIM25 ZDHHC9 ZDHHC5 CHD3 ZDHHC8

1.25e-04471468M39009
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM

NOTCH2 NOTCH4

1.55e-046462M27068
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION

NOTCH2 NOTCH4

5.62e-0411462M47865
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380

NOTCH2 NOTCH4

6.73e-0412462M47532
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381

NOTCH2 NOTCH4

6.73e-0412462M47533
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

NOTCH2 NOTCH4

7.94e-0413462M47423
PathwayREACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY

TRAF3 TRIM25

1.06e-0315462M953
PathwayREACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE

PCSK5 ZDHHC8 PCSK9

1.07e-0362463MM14686
PathwayREACTOME_DISEASES_OF_METABOLISM

ADAMTS12 HSPG2 GALNT12 NOTCH2 NOTCH4

1.28e-03250465M27554
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PCSK5 HSPG2 FRAS1 SHANK2 MEGF8 NFX1 ZDHHC5 NBL1 DGKQ ZFYVE26 LAMC3 REV3L ZDHHC8 LYST NOTCH2 SMAD7

1.46e-101105651635748872
Pubmed

Functional proteomics mapping of a human signaling pathway.

HSPG2 FBLN1 PTPN12 RBBP6 LUC7L2 TENT5A PPP1R13B GRN CHD3 PRDM4 NOTCH2 SMAD7

9.21e-10591651215231748
Pubmed

Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system.

ZDHHC20 ZDHHC9 ZDHHC5 ZDHHC8

1.99e-081665423034182
Pubmed

S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity.

ZDHHC20 ZDHHC9 ZDHHC8

2.49e-08465334599882
Pubmed

Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins.

ZDHHC20 ZDHHC9 ZDHHC5 ZDHHC8

5.26e-082065416647879
Pubmed

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.

PCSK5 HSPG2 FBLN1 RNF31 MEGF8 GRN

9.41e-0811865621078624
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

PCSK5 HSPG2 FBLN1 PDGFD SLIT3 GRN PCSK9

4.22e-0724865724006456
Pubmed

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.

STOX2 SHANK2 ZDHHC5 PRICKLE2 ZDHHC8 TENM2

1.91e-0619765636604605
Pubmed

Notch receptors and hematopoiesis.

NOTCH2 NOTCH4

3.44e-06265211532344
Pubmed

A novel interaction between perlecan protein core and progranulin: potential effects on tumor growth.

HSPG2 GRN

3.44e-06265212900424
Pubmed

The Tat protein of the caprine arthritis encephalitis virus interacts with the Notch2 EGF-like repeats and the epithelin/granulin precursor.

GRN NOTCH2

3.44e-06265212931033
Pubmed

Ankyrin-G palmitoylation and βII-spectrin binding to phosphoinositide lipids drive lateral membrane assembly.

ZDHHC5 ZDHHC8

3.44e-06265225049274
Pubmed

notch2, notch4 gene polymorphisms in psoriasis vulgaris.

NOTCH2 NOTCH4

3.44e-06265223587900
Pubmed

Inflammation dysregulates Notch signaling in endothelial cells: implication of Notch2 and Notch4 to endothelial dysfunction.

NOTCH2 NOTCH4

3.44e-06265220643108
Pubmed

In vivo evidence that furin from hepatocytes inactivates PCSK9.

PCSK5 PCSK9

1.03e-05365221147780
Pubmed

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications.

PCSK5 PCSK9

1.03e-05365216912035
Pubmed

Differential expression of Notch genes in human osteoblastic cells.

NOTCH2 NOTCH4

1.03e-05365211836628
Pubmed

Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms.

LUC7L LUC7L2

1.03e-05365233852859
Pubmed

ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.

ZDHHC9 ZDHHC5

1.03e-05365238599239
Pubmed

Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain.

NOTCH2 NOTCH4

1.03e-05365211823422
Pubmed

Notch signaling: cell fate control and signal integration in development.

NOTCH2 NOTCH4

1.03e-05365210221902
Pubmed

The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis.

ZDHHC9 ZDHHC5

1.03e-05365238530158
Pubmed

Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking.

ZDHHC5 ZDHHC8

1.03e-05365222325201
Pubmed

Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.

ZDHHC5 ZDHHC8

1.03e-05365219801377
Pubmed

Transcriptome-based systematic identification of extracellular matrix proteins.

HSPG2 FBLN1 FRAS1 LAMC3

1.50e-057965418757743
Pubmed

Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.

TRIM25 RBBP6 RNF41

1.97e-052865335474067
Pubmed

Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer.

NOTCH2 NOTCH4

2.06e-05465228061457
Pubmed

The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors.

NOTCH2 NOTCH4

2.06e-05465224145721
Pubmed

A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma.

NOTCH2 NOTCH4

2.06e-05465220069356
Pubmed

Expression and clinical significance of Notch receptors in human renal cell carcinoma.

NOTCH2 NOTCH4

2.06e-05465219404845
Pubmed

Notch signaling pathway regulates the growth and the expression of inflammatory cytokines in mouse basophils.

NOTCH2 NOTCH4

2.06e-05465228669409
Pubmed

Evolutionary analysis of vertebrate Notch genes.

NOTCH2 NOTCH4

2.06e-05465211466531
Pubmed

Abnormal expression pattern of Notch receptors, ligands, and downstream effectors in the dorsolateral prefrontal cortex and amygdala of suicidal victims.

NOTCH2 NOTCH4

2.06e-05465224151014
Pubmed

Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): evolutionary conservation of multiple expression domains in amphioxus and vertebrates.

NOTCH2 NOTCH4

2.06e-05465211401408
Pubmed

Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation.

NOTCH2 NOTCH4

2.06e-05465210194420
Pubmed

Functional conservation of mouse Notch receptor family members.

NOTCH2 NOTCH4

2.06e-0546528898100
Pubmed

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.

NOTCH2 NOTCH4

2.06e-05465211459941
Pubmed

Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9.

PCSK5 PCSK9

2.06e-05465218245819
Pubmed

Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias.

NOTCH2 NOTCH4

2.06e-05465218184405
Pubmed

Notch signaling in the mammalian central nervous system: insights from mouse mutants.

NOTCH2 NOTCH4

2.06e-05465215917835
Pubmed

Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma.

NOTCH2 NOTCH4

2.06e-05465223444212
Pubmed

Deregulated expression of Notch receptors in human hepatocellular carcinoma.

NOTCH2 NOTCH4

2.06e-05465217920003
Pubmed

Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta.

NOTCH2 NOTCH4

3.43e-05565221726900
Pubmed

NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation.

TRAF3 PPP1R13B

3.43e-05565225072696
Pubmed

Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL.

NOTCH2 NOTCH4

3.43e-05565221124806
Pubmed

Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4).

NOTCH2 NOTCH4

3.43e-05565223675950
Pubmed

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.

NOTCH2 NOTCH4

3.43e-05565211101851
Pubmed

Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3.

FRAS1 SLIT3

3.43e-05565223536828
Pubmed

Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice.

NOTCH2 NOTCH4

3.43e-05565215882997
Pubmed

Association of Notch pathway down-regulation with Triple Negative/Basal-like breast carcinomas and high tumor-infiltrating FOXP3+ Tregs.

NOTCH2 NOTCH4

3.43e-05565227118257
Pubmed

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.

PCSK5 FRAS1 MEGF8 SLIT3

3.81e-0510065425807483
Pubmed

RBP-L, a transcription factor related to RBP-Jkappa.

NOTCH2 NOTCH4

5.13e-0566529111338
Pubmed

Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.

NOTCH2 NOTCH4

5.13e-05665220870902
Pubmed

Characterization of Notch receptor expression in the developing mammalian heart and liver.

NOTCH2 NOTCH4

5.13e-05665212244553
Pubmed

PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain.

PCSK5 PCSK9

5.13e-05665220453200
Pubmed

Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site.

NOTCH2 NOTCH4

5.13e-05665218239137
Pubmed

Notch4 Negatively Regulates the Inflammatory Response to Mycobacterium tuberculosis Infection by Inhibiting TAK1 Activation.

NOTCH2 NOTCH4

5.13e-05665229228365
Pubmed

Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal.

NOTCH2 NOTCH4

5.13e-05665219503073
Pubmed

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.

NOTCH2 NOTCH4

5.13e-05665218299578
Pubmed

Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction.

TRIM25 RNF31

5.13e-05665221292167
Pubmed

Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins.

HSPG2 FBLN1

5.13e-05665210544250
Pubmed

The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates.

PCSK5 PCSK9

5.13e-05665218039650
Pubmed

Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene.

NOTCH2 NOTCH4

5.13e-05665215019995
Pubmed

Notch controls the magnitude of T helper cell responses by promoting cellular longevity.

NOTCH2 NOTCH4

5.13e-05665222615412
Pubmed

Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice.

NOTCH2 NOTCH4

5.13e-05665221991352
Pubmed

Hepatitis B Virus-Induced Parkin-Dependent Recruitment of Linear Ubiquitin Assembly Complex (LUBAC) to Mitochondria and Attenuation of Innate Immunity.

TRAF3 RNF31

7.18e-05765227348524
Pubmed

Human ligands of the Notch receptor.

NOTCH2 NOTCH4

7.18e-05765210079256
Pubmed

The distribution of Notch receptors and their ligands during articular cartilage development.

NOTCH2 NOTCH4

7.18e-05765212846471
Pubmed

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.

NOTCH2 NOTCH4

7.18e-05765211518718
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

LUC7L FBLN1 TRAF3 MEGF8 LUC7L2 GRN NOTCH2

8.39e-0556065721653829
Pubmed

Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients.

NOTCH2 NOTCH4

9.56e-05865222156581
Pubmed

Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.

NBPF3 PRICKLE2

9.56e-05865219303062
Pubmed

Notch1 and Jagged1 expression by the developing pulmonary vasculature.

NOTCH2 NOTCH4

9.56e-05865212242716
Pubmed

Genomic response to Wnt signalling is highly context-dependent--evidence from DNA microarray and chromatin immunoprecipitation screens of Wnt/TCF targets.

SLIT3 TENM2

9.56e-05865219563800
Pubmed

Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.

NOTCH2 NOTCH4

9.56e-0586529858718
Pubmed

Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

MEGF8 SLIT3

1.23e-0496529693030
Pubmed

Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system.

NOTCH2 NOTCH4

1.23e-04965211118901
Pubmed

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.

NOTCH2 NOTCH4

1.23e-04965216245338
Pubmed

The activation and physiological functions of the proprotein convertases.

PCSK5 PCSK9

1.23e-04965218343183
Pubmed

Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.

NOTCH2 NOTCH4

1.23e-04965212370315
Pubmed

The prohormone theory and the proprotein convertases: it is all about serendipity.

PCSK5 PCSK9

1.23e-04965221805236
Pubmed

The proprotein convertases, 20 years later.

PCSK5 PCSK9

1.23e-04965221805237
Pubmed

The biology and therapeutic targeting of the proprotein convertases.

PCSK5 PCSK9

1.23e-04965222679642
Pubmed

The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.

PCSK5 PCSK9

1.23e-04965223775089
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

STOX2 NFX1 ZDHHC5 PPP1R13B ZDHHC8

1.36e-0426365534702444
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

PCSK5 HSPG2 FBLN1 RNF31 MEGF8 TENT5A GRN

1.40e-0460865716713569
Pubmed

Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.

NOTCH2 NOTCH4

1.53e-041065223665443
Pubmed

Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections.

NOTCH2 NOTCH4

1.53e-041065233915108
Pubmed

Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.

NOTCH2 NOTCH4

1.87e-041165216607638
Pubmed

Binding of mouse and human fibulin-2 to extracellular matrix ligands.

HSPG2 FBLN1

1.87e-04116527500359
Pubmed

Coexpression of Cux-1 and Notch signaling pathway components during kidney development.

NOTCH2 NOTCH4

1.87e-041165215499562
Pubmed

SVEP1 is an endogenous ligand for the orphan receptor PEAR1.

HSPG2 PEAR1

1.87e-041165236792666
Pubmed

Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.

NOTCH2 NOTCH4

1.87e-041165210878608
Pubmed

A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.

NOTCH2 NOTCH4

1.87e-04116529187150
Pubmed

Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions.

NOTCH2 NOTCH4

1.87e-041165212866128
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

FRAS1 CTNNA3 PPP1R13B REV3L

1.93e-0415265434299191
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

LUC7L STOX2 MEGF8 ZNF286B AKAP11 FGD6 LYST NOTCH2

1.98e-0486165836931259
Pubmed

Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium.

NOTCH2 NOTCH4

2.24e-041265210952889
Pubmed

The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon.

TRAF3 RNF41

2.24e-041265219483718
Pubmed

Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.

NOTCH2 NOTCH4

2.24e-041265215465494
InteractionATN1 interactions

PCSK5 HSPG2 FBLN1 TRIM25 RNF31 MEGF8 GRN LYST

1.18e-07187638int:ATN1
InteractionTOP3B interactions

PCSK5 HSPG2 FRAS1 TRIM25 SHANK2 MEGF8 NFX1 ZDHHC5 NBL1 DGKQ ZFYVE26 LAMC3 GRN REV3L ZDHHC8 LYST NOTCH2 SMAD7

3.37e-0714706318int:TOP3B
InteractionZFP41 interactions

FBLN1 FRAS1 TRIM25 GRN NOTCH2

9.38e-0757635int:ZFP41
InteractionZNF444 interactions

HSPG2 FBLN1 FRAS1 TRIM25 RNF31 NOTCH2

9.78e-07106636int:ZNF444
InteractionCACNA1A interactions

PCSK5 HSPG2 FBLN1 MEGF8 GRN REV3L

2.34e-06123636int:CACNA1A
InteractionPRG2 interactions

PCSK5 HSPG2 FRAS1 GALNT12 LAMC3 CHD3 NOTCH2 PCSK9

2.86e-06285638int:PRG2
InteractionIGFL3 interactions

PCSK5 FBLN1 FRAS1 GRN NOTCH2

3.70e-0675635int:IGFL3
InteractionELSPBP1 interactions

FBLN1 MEGF8 GALNT12 NOTCH2 PCSK9

1.01e-0592635int:ELSPBP1
InteractionAGRP interactions

FBLN1 GRN NOTCH2

1.03e-0514633int:AGRP
InteractionPRG3 interactions

PCSK5 FRAS1 NOTCH2 PCSK9

1.65e-0549634int:PRG3
InteractionMAML3 interactions

NFX1 NOTCH2 NOTCH4

3.20e-0520633int:MAML3
InteractionLYPD1 interactions

PCSK5 FRAS1 MEGF8 NOTCH2

3.24e-0558634int:LYPD1
InteractionFBXO2 interactions

PCSK5 HSPG2 FRAS1 TRIM25 MEGF8 LAMC3 GRN NOTCH2

4.06e-05411638int:FBXO2
InteractionIL5RA interactions

PCSK5 HSPG2 FRAS1 MEGF8 PCSK9

4.30e-05124635int:IL5RA
InteractionPSG3 interactions

FBLN1 MEGF8 TENT5A

4.30e-0522633int:PSG3
InteractionCFC1 interactions

PCSK5 FRAS1 MEGF8 GALNT12 NOTCH2

4.64e-05126635int:CFC1
InteractionZSCAN21 interactions

FRAS1 ZNF330 GRN PRDM4 NOTCH2

5.00e-05128635int:ZSCAN21
InteractionSDF2L1 interactions

PCSK5 HSPG2 FRAS1 MEGF8 GALNT12 LAMC3 PCSK9

6.40e-05322637int:SDF2L1
InteractionGFI1B interactions

HSPG2 FBLN1 RNF31 MEGF8 GRN

6.67e-05136635int:GFI1B
InteractionSLURP1 interactions

PCSK5 FBLN1 MEGF8 GRN NOTCH2

8.75e-05144635int:SLURP1
InteractionZNF408 interactions

HSPG2 FRAS1 ZNF330 GRN NOTCH2

9.04e-05145635int:ZNF408
InteractionEGFL7 interactions

TRIM25 GRN NOTCH2 NOTCH4

9.89e-0577634int:EGFL7
InteractionZNF517 interactions

FBLN1 GRN RNF41

1.00e-0429633int:ZNF517
InteractionPI15 interactions

PCSK5 HSPG2 GALNT12 PCSK9

1.32e-0483634int:PI15
InteractionPRELP interactions

HSPG2 FRAS1 MEGF8

1.35e-0432633int:PRELP
InteractionSERINC5 interactions

TRIM25 RBBP6 RNF41

1.35e-0432633int:SERINC5
InteractionSIRPD interactions

HSPG2 FRAS1 MEGF8 GALNT12

1.52e-0486634int:SIRPD
InteractionIVNS1ABP interactions

RNF31 LUC7L2 NFX1 PRICKLE2 CHD3

2.49e-04180635int:IVNS1ABP
InteractionHSPG2 interactions

HSPG2 FBLN1 TRIM25 GRN

2.51e-0498634int:HSPG2
InteractionNBPF1 interactions

NBPF3 TRIM25

2.66e-048632int:NBPF1
Cytoband5q35

ADAMTS12 SLIT3

4.75e-04236425q35
Cytoband4q35.1

STOX2 CLDN22

1.17e-03366424q35.1
GeneFamilyZinc fingers DHHC-type|Ankyrin repeat domain containing

ZDHHC20 ZDHHC9 ZDHHC5 ZDHHC8

4.10e-072447476
GeneFamilyProprotein convertase subtilisin/kexin family

PCSK5 PCSK9

2.35e-049472973
GeneFamilyZinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors

ZFYVE26 FGD6

2.93e-033147281
GeneFamilyAnkyrin repeat domain containing

SHANK2 PPP1R13B NOTCH2 NOTCH4

3.56e-03242474403
GeneFamilyRing finger proteins

TRIM25 RNF31 TRIM61 RNF41

5.59e-0327547458
CoexpressionLAKE_ADULT_KIDNEY_C5_PROXIMAL_TUBULE_EPITHELIAL_CELLS_STRESS_INFLAM

PCSK5 LUC7L FRAS1 SHANK2 TENT5A SLIT3 CTNNA3 PRICKLE2 TENM2

6.64e-07417639M39224
CoexpressionZENG_GU_ICB_CONTROL_METAGENE_14_PRECICTIVE_ICB_RESPONSE

ADAMTS12 PCSK5 TENT5A NBL1 ADGRF5 NOTCH2

8.18e-06198636MM17083
CoexpressionGAO_LARGE_INTESTINE_ADULT_CJ_IMMUNE_CELLS

FBLN1 STOX2 SCARF2 PDGFD LAMC3 ADGRF5 NOTCH4 PEAR1

2.75e-05505638M39167
CoexpressionCUI_TCF21_TARGETS_2_DN

PTPN12 RBBP6 LUC7L2 TENT5A PPP1R13B ADGRF5 LYST TENM2 ADCY1 NOTCH4

3.42e-058546310M1533
CoexpressionDESCARTES_FETAL_MUSCLE_SMOOTH_MUSCLE_CELLS

SLIT3 CORIN LAMC3 WDR72

4.39e-0581634M40258
CoexpressionCUI_TCF21_TARGETS_2_DN

PTPN12 RBBP6 LUC7L2 TENT5A PPP1R13B ADGRF5 LYST TENM2 ADCY1 NOTCH4

4.75e-058886310MM1018
CoexpressionTORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP

ZDHHC9 TENT5A PPP1R13B GRN FGD6 LYST

5.09e-05274636M2348
CoexpressionNABA_CORE_MATRISOME

HSPG2 FBLN1 FRAS1 SLIT3 LAMC3 FBN3

5.20e-05275636M5884
CoexpressionTORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP

ZDHHC9 TENT5A PPP1R13B GRN FGD6 LYST

5.41e-05277636MM917
CoexpressionBERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN

ADAMTS12 HSPG2 ELAPOR2 PDGFD SLIT3

7.36e-05180635M10605
CoexpressionGRYDER_PAX3FOXO1_TOP_ENHANCERS

HSPG2 PTPN12 ZNF330 TENT5A GRN MYO18B NOTCH2

8.94e-05441637M172
CoexpressionNABA_ECM_GLYCOPROTEINS

FBLN1 FRAS1 SLIT3 LAMC3 FBN3

1.10e-04196635M3008
CoexpressionPEREZ_TP53_AND_TP63_TARGETS

PCSK5 STOX2 PPP1R13B ADCY1 SMAD7

1.42e-04207635M14566
CoexpressionNABA_MATRISOME

ADAMTS12 PCSK5 HSPG2 FBLN1 FRAS1 MEGF8 PDGFD SLIT3 LAMC3 FBN3

1.57e-0410266310M5889
CoexpressionJONES_OVARY_MAST_CELL

HSPG2 FBLN1 ADGRF5

1.99e-0447633M48356
CoexpressionHE_LIM_SUN_FETAL_LUNG_C3_OMD_POS_ENDOTHELIAL_CELL

PCSK5 FBLN1 TENT5A PDGFD SLIT3 SMAD7

2.10e-04355636M45758
CoexpressionAtlaskidney_P0_JuxtaGlom_Ren1_k-means-cluster#4_top-relative-expression-ranked_500

ADAMTS12 TENT5A SLIT3 CTNNA3 CORIN NOTCH2

5.47e-06155616gudmap_kidney_P0_JuxtaGlom_Ren1_k4_500
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 FBLN1 RNF31 TENT5A SLIT3 LAMC3 PEAR1

5.24e-09171647972fab891135bd755d5526cbc5a963200067b0a6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 FBLN1 RNF31 TENT5A SLIT3 LAMC3 PEAR1

5.24e-091716472a77ed79c6f2e700e789c80451a70ecb31639719
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

STOX2 FRAS1 SHANK2 CTNNA3 PPP1R13B FBN3

2.26e-07179646815b959ce8721c5ded70c0ca6e318dafc691746e
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1-41|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZCCHC4 HSPG2 FBLN1 ZDHHC9 SLIT3 NBL1

2.57e-0718364607ca2786e62eca9feecf5e54a11864a960f7641a
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN1 RNF31 TENT5A SLIT3 LAMC3 ADCY1

2.74e-07185646e1fbec55b71f604189eb2431768fadbaa0453a83
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN1 RNF31 TENT5A SLIT3 LAMC3 ADCY1

2.74e-071856469d933cd5ebc8368fd37aa83113d2dfa6938ff72d
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

HSPG2 STOX2 FRAS1 SHANK2 CTNNA3 FBN3

2.92e-071876464ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

STOX2 FRAS1 SHANK2 CTNNA3 PPP1R13B FBN3

3.21e-071906468aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ELAPOR2 STOX2 SHANK2 CTNNA3 PPP1R13B ADGRF5

3.31e-0719164634cc997e4e5c727495f321e6807a84aa124da486
ToppCellASK454-Mesenchymal|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

PCSK5 FBLN1 FRAS1 SLIT3 NBL1 LAMC3

3.31e-07191646e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

STOX2 SHANK2 CTNNA3 PPP1R13B ADGRF5 FBN3

3.31e-07191646ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCellEpithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|World / Lineage, Cell type, age group and donor

STOX2 SHANK2 CTNNA3 PPP1R13B ADGRF5 FBN3

3.31e-07191646d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCellASK454-Mesenchymal-Fibroblast|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

PCSK5 FBLN1 FRAS1 SLIT3 NBL1 LAMC3

3.31e-071916461726add3f392a061536b7aff72ba84303f4a0b1f
ToppCellMesenchymal-matrix_fibroblast_1_cell|World / Lineage, Cell type, age group and donor

ADAMTS12 FBLN1 FRAS1 SLIT3 NBL1 TENM2

3.51e-07193646acad568621ed677031797b8c2e34dafea798d681
ToppCellFetal_29-31_weeks-Epithelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

STOX2 SHANK2 CTNNA3 PPP1R13B ADGRF5 FBN3

3.51e-07193646a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_prolif-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ADAMTS12 FBLN1 SLIT3 LAMC3 ADGRF5 PEAR1

3.62e-07194646a7731378f44ca1a229311686caf5740c742d21ba
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-arteriolar_fibroblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ADAMTS12 FBLN1 SCARF2 PRICKLE2 NBL1 ADCY1

4.20e-0719964695d95e9b7bd3933188998ae94986213eb0f1e5ea
ToppCellParenchymal-10x5prime-Stromal-Fibroblastic-Fibro_alveolar|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ADAMTS12 FBLN1 FRAS1 SCARF2 SLIT3 NBL1

4.33e-072006468c62f05c6042f24287a73fbdf80ff4a56f7ff403
ToppCellCOVID-19-kidney-Mito-rich_Int|kidney / Disease (COVID-19 only), tissue and cell type

KRTAP1-4 CTNNA3 LAMC3 MYO18B FBN3

1.19e-0612964557b705106aec7bbfc587de1ccd4f2335fc44dd6f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

4.36e-06168645d19a115365c5415e51c039718d7669de788fcf33
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

STOX2 FRAS1 SHANK2 SLIT3 WDR72

4.36e-06168645a086c306be430adf0632ba53e98cd8014d2de330
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 SLIT3 LAMC3 PEAR1

4.49e-06169645a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCell-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

FBLN1 SLIT3 NBL1 LAMC3 ADCY1

5.03e-0617364588be9182fbb1bc83531cd41e59ea57c112a21d54
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 HSPG2 PDGFD ADGRF5 NOTCH4

5.47e-0617664577516048aefbe1f48e825052756df0c310c1c486
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN1 PRICKLE2 NBL1 LAMC3 REV3L

5.63e-061776459ec7f1e64312d26d434b3312b58386715dbad644
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN1 PRICKLE2 NBL1 LAMC3 REV3L

5.63e-06177645016277dfd59b1793fddaaadc2b3f41622d76ce3a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 SCARF2 TENT5A SLIT3 LAMC3

5.78e-0617864578a0c6340001a77f5b2d890b6263f574af2e72da
ToppCelldroplet-Liver-LIVER_NPC-30m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCARF2 PDGFD ADGRF5 NOTCH4 PEAR1

5.94e-06179645025d414ec88d5680d99c8173e70ee3bb0b694f74
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

PCSK5 HSPG2 PDGFD ADGRF5 NOTCH4

5.94e-061796451ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 SLIT3 LAMC3 PEAR1

6.27e-06181645c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ADAMTS12 FBLN1 FRAS1 SLIT3 TENM2

6.27e-061816459ede19228ba5c0668a9c06c915510b95585216ef
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 SLIT3 LAMC3 PEAR1

6.27e-06181645c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCelldroplet-Liver-Npc-21m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 PDGFD ADGRF5 NOTCH4 PEAR1

6.44e-06182645dc55de945c6f78f32eb3a1b3520835eb8417e068
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

6.44e-0618264544764676ed3f51ba171ce63f669390392fa50a43
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

6.44e-06182645d82f59a3f930a840dde27dc6ab024f227a26d446
ToppCelldroplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 PDGFD ADGRF5 NOTCH4 PEAR1

6.44e-06182645010a7364da46101cb5068891fd7bc712ea8f13bd
ToppCelldroplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 PDGFD ADGRF5 NOTCH4 PEAR1

6.44e-06182645b1ec2015aad1181eac1bbf8d48ad6f2f7ed24a01
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ELAPOR2 STOX2 SHANK2 CORIN ADGRF5

6.62e-061836456847c1252d6bb105524f812658112517fd351eab
ToppCelldroplet-Mammary_Gland-nan-18m-Mesenchymal-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 SLIT3 CTNNA3 NBL1 LAMC3

6.79e-06184645fe4d3def3da4ffdea5ae6bb059f5397efd58fef3
ToppCell367C-Lymphocytic-NK_cells-NK_cell_A|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PCSK5 PTPN12 TENT5A PDGFD CLDN22

6.97e-0618564525781cf68e693e97dc1885e2879ab24fa946b51e
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

STOX2 SHANK2 PPP1R13B ADGRF5 FBN3

7.16e-061866452ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCellPCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SHANK2 CTNNA3 PPP1R13B ADGRF5 WDR72

7.35e-06187645db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCelldroplet-Bladder-Unstain-18m-Epithelial-bladder_mesenchymal_cell_(Scara5+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 FBLN1 SLIT3 NBL1 SMAD7

7.35e-061876457beba2a5d5978f2ae7d8bde10815705cf2572211
ToppCellfacs-Bladder-nan-24m-Epithelial-bladder_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 DRAXIN SLIT3 NBL1 SMAD7

7.35e-061876452c145e9d11424939dd99012a8cedf5d998b966e9
ToppCellPCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SHANK2 CTNNA3 PPP1R13B ADGRF5 FBN3

7.54e-061886450d86044bc340e3efb90d0022dd299873639d831c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

7.74e-0618964571397e993a77d70b2eeede240bdfc7660b558987
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

7.74e-061896454eea4759520c312bd17a681034d8074e47093d2b
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

CTNNA3 PPP1R13B CORIN MYO18B TENM2

7.74e-061896459c1debd65c13d63fd4f3158917d621b44b714c26
ToppCelldroplet-Lung-immune-endo-depleted|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 FBLN1 SCARF2 SLIT3 NBL1

7.74e-06189645c3fb363bb0156ffb3367c200f548faebda64ab4a
ToppCelldroplet-Lung-immune-endo-depleted-3m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 FBLN1 SCARF2 SLIT3 NBL1

7.74e-061896452a2953f6b1b7d070d739dcaf7285fce6e097d9e4
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 PDGFD ADGRF5 NOTCH4 SMAD7

7.74e-061896459da012fdfa9a8d488cab710a463a1d70e89f990c
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADAMTS12 FBLN1 FRAS1 SLIT3 NBL1

7.74e-06189645203c80030df08ae112f9ae4043709f455d87ce89
ToppCellRV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

STOX2 TENT5A CTNNA3 MYO18B TENM2

7.74e-061896450a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCelldroplet-Lung-3m|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HSPG2 FBLN1 SCARF2 SLIT3 NBL1

7.74e-061896455a636e952da9b1fd26aa17f7b129054f2da322b5
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

STOX2 TENT5A CTNNA3 MYO18B TENM2

7.94e-0619064593c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellLV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

CTNNA3 PPP1R13B CORIN MYO18B TENM2

7.94e-06190645de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

7.94e-061906452306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 FBLN1 SCARF2 SLIT3 NBL1

7.94e-061906459cd147a174017ebda23cc47b6d4552d898acd092
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

7.94e-061906451f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

8.14e-06191645a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCellLV-06._Ventricular_Cardiomyocyte_II|LV / Chamber and Cluster_Paper

CTNNA3 PPP1R13B CORIN MYO18B TENM2

8.14e-0619164525f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 HSPG2 PDGFD ADGRF5 NOTCH4

8.14e-06191645b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2|Children_(3_yrs) / Lineage, Cell type, age group and donor

ELAPOR2 STOX2 SHANK2 PPP1R13B ADGRF5

8.14e-06191645a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPG2 PDGFD ADGRF5 CLDN22 NOTCH4

8.14e-06191645adb2e3efcad02889d8229325080da5e7830fd3ae
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 PDGFD ADGRF5 NOTCH4 SMAD7

8.14e-061916453307dbccadb09c62b0e1c0235ec89bb294d748c3
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 SLIT3 PRICKLE2 LAMC3

8.14e-06191645806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

8.14e-0619164539092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

ADAMTS12 SLIT3 LAMC3 ADGRF5 PEAR1

8.14e-0619164578c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCell10x5'v1-week_17-19-Endothelial-stroma-proliferating_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 PRICKLE2 NBL1 ADGRF5 ADCY1

8.14e-06191645dc9e5eb6aa31b8d79aeec33e59b9138dfb469a3b
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

ELAPOR2 STOX2 SHANK2 PPP1R13B ADGRF5

8.14e-06191645e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TENT5A SLIT3 LAMC3 ADGRF5 PEAR1

8.14e-061916457b0d42a877540dbb346a76a62403e0d5d3e07fa6
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ADAMTS12 FBLN1 FRAS1 SLIT3 NBL1

8.14e-061916456688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

8.14e-06191645ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TENT5A SLIT3 LAMC3 ADGRF5 PEAR1

8.14e-06191645cd854b9c426924fdc84bf7f411f6dea447143e79
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

8.35e-061926459093a9e94a25682d109a7f6edc256a25a61103a0
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

8.35e-06192645bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

HSPG2 STOX2 PDGFD ADGRF5 NOTCH4

8.35e-0619264527ff3621e177e7932dd44dd6baa81551ea75a874
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

8.35e-061926455105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

8.35e-06192645d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

8.35e-061926459ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCellEpithelial-alveolar_epithelial_cell_type_2|World / Lineage, Cell type, age group and donor

ELAPOR2 STOX2 SHANK2 PPP1R13B ADGRF5

8.35e-0619264558c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

STOX2 SHANK2 PPP1R13B ADGRF5 FBN3

8.35e-0619264529f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ADAMTS12 FBLN1 FRAS1 SLIT3 NBL1

8.35e-0619264599ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ELAPOR2 STOX2 SHANK2 PPP1R13B ADGRF5

8.35e-06192645fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

8.35e-061926450ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTS12 FBLN1 STOX2 PDGFD SLIT3

8.35e-06192645deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

8.56e-06193645f1199518c3626fd29bfce65070dd21a660671213
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

8.56e-06193645c8c21eee8c6c086dc2faf416669cd4a002870fbe
ToppCelldroplet-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 FBLN1 SCARF2 KRTAP1-4 NBL1

8.56e-061936452d891c00b8f0aace17d4c300b63e2341dcffa199
ToppCellfacs-Lung-nan-3m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 FBLN1 SCARF2 SLIT3 NBL1

8.56e-06193645d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D231|Adult / Lineage, Cell type, age group and donor

ADAMTS12 FBLN1 SLIT3 NBL1 TENM2

8.56e-06193645ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

8.56e-061936455b602b1702283184bd3943c2a6f2290b7c37e407
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

8.78e-0619464581713e0409e8be695ba5dfdc67a997b33435dd9e
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADAMTS12 FBLN1 SLIT3 NBL1 TENM2

8.78e-06194645011e14d9ed1393275f892060e7708ffadcd0767f
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Mesenchymal-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 FBLN1 SCARF2 SLIT3 NBL1

8.78e-06194645da926441053b499cb5107ccb116fb1b3844d82b7
ToppCellfacs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFD PRICKLE2 PPP1R13B ADGRF5 NOTCH4

8.78e-06194645f159ef8541d75a4e98468947f231bb463bec922c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 TENT5A SLIT3 LAMC3

8.78e-06194645cf0244a29934e515446ac917d3c30672b460fb04
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 SLIT3 CORIN LAMC3

8.78e-06194645240d122dcb9dd1ab2867503ad85869853adcacae
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADAMTS12 FRAS1 SLIT3 NBL1 TENM2

8.78e-0619464535f132cc38ac133be01834ed0946188aa0757eb4
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 FBLN1 SLIT3 CORIN LAMC3

8.78e-06194645ae7df037592f1c20c9d32be15fe6fc3c562ebeb1
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

HSPG2 PDGFD ADGRF5 NOTCH4

1.73e-0550344GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_ENDO_1
DrugSanguinarine [2447-54-3]; Down 200; 12uM; MCF7; HT_HG-U133A

TRAF3 ZFYVE26 AKAP11 RNF41 CHD3 ADCY1 NOTCH2

1.09e-061916474168_DN
Diseaseglycosyl ceramide (d18:1/20:0, d16:1/22:0) measurement

CORIN PCSK9

8.77e-057612EFO_0800551
Diseaseglycosyl-N-palmitoyl-sphingosine (d18:1/16:0) measurement

CORIN PCSK9

1.50e-049612EFO_0800476
Diseasedementia (is_implicated_in)

GRN NOTCH4

2.74e-0412612DOID:1307 (is_implicated_in)
DiseaseParoxysmal atrial fibrillation

HSPG2 SLIT3 MYO18B SMAD7

3.10e-04156614C0235480
Diseasefamilial atrial fibrillation

HSPG2 SLIT3 MYO18B SMAD7

3.10e-04156614C3468561
DiseasePersistent atrial fibrillation

HSPG2 SLIT3 MYO18B SMAD7

3.10e-04156614C2585653
Diseasesevere acute respiratory syndrome, COVID-19

ADAMTS12 ZCCHC4 SCARF2 PRICKLE2 LYST TENM2

3.21e-04447616EFO_0000694, MONDO_0100096
DiseaseAtrial Fibrillation

HSPG2 SLIT3 MYO18B SMAD7

3.42e-04160614C0004238
Diseasenon-high density lipoprotein cholesterol measurement

PCSK5 FBLN1 PDGFD DGKQ PCSK9 SMAD7 WDR72

6.57e-04713617EFO_0005689
Diseaseseborrheic dermatitis

ELAPOR2 PRICKLE2

7.80e-0420612EFO_1000764
Diseasepsoriatic arthritis

CTNNA3 REV3L NOTCH4

7.87e-0487613EFO_0003778
Diseasediffuse plaque measurement

PCSK5 SHANK2 RBBP6 TENT5A FBN3 NOTCH4 WDR72

9.40e-04758617EFO_0010699
Diseaseatrial fibrillation

HSPG2 SLIT3 CTNNA3 MYO18B SMAD7

1.02e-03371615EFO_0000275
Diseasecorpus callosum mid-anterior volume measurement

ZDHHC5 WDR72

1.43e-0327612EFO_0010297
Diseaseopioid dependence

CTNNA3 CORIN MYO18B WDR72

1.48e-03237614EFO_0005611
Diseaseresponse to angiotensin receptor blocker

STOX2 TENM2

1.76e-0330612EFO_0010735
Diseasecolorectal cancer (is_implicated_in)

PTPN12 GALNT12 SMAD7

2.04e-03121613DOID:9256 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
NATCCSDHLHCCPQD

GRN

236

P28799
SDHLHCCPQDTVCDL

GRN

241

P28799
ALHCEVCELHLHPDC

DGKQ

146

P52824
THCSLSAAKDCVPEC

AKAP11

996

Q9UKA4
ECIDVDECTSSPCHH

FBN3

446

Q75N90
DECTSSPCHHGDCVN

FBN3

451

Q75N90
ECDLNPHICLHGDCE

FBN3

1241

Q75N90
TPLHCAASCNSVHLC

PPP1R13B

956

Q96KQ4
ECCFSCPQTHITHTQ

ADAMTS12

1566

P58397
ELCECNGHSDLCHPE

HSPG2

1561

P98160
HKETDDCDAANICCH

KIAA1107

546

Q9UPP5
LLCHLDDACISNPCH

NOTCH2

371

Q04721
FCLHEINECSSHPCL

NOTCH2

1021

Q04721
CTSVHCHPDCLTCSQ

FRAS1

416

Q86XX4
LTCSQSPDHCDLCQD

FRAS1

426

Q86XX4
CKSHLLDCCPHDILA

LUC7L

36

Q9NQ29
DIQLDHHERCDCICS

PDGFD

351

Q9GZP0
HMDDSHCLHCCNTSD

PCSK5

1696

Q92824
IHASCCHAPGLECKV

PCSK9

596

Q8NBP7
APCTCDREHSLSCHP

PEAR1

361

Q5VY43
HELSSEPKRSCCRCH

FAM205A

36

Q6ZU69
TLCPLCEEHRDCHAC

MEGF8

896

Q7Z7M0
CEEHRDCHACTQDPF

MEGF8

901

Q7Z7M0
CDGFLTCHECLQSHE

MEGF8

1006

Q7Z7M0
PECTQTCARVHECDH

NFX1

766

Q12986
SCTPPSCCQLHHAEA

KRTAP1-4

81

P0C5Y4
LHCSCQACGKEPSHE

NBL1

116

P41271
SAEACPLCTEHDFHE

ELAPOR2

871

A8MWY0
TALLESDEHTCPTCH

RBBP6

286

Q7Z6E9
HHAECLKPRCAACDE

PRICKLE2

186

Q7Z3G6
EQCCHSQLEELHCAT

FBLN1

66

P23142
EECAITCSNSHHPCE

NBPF3

261

Q9H094
CLLHCAACSSHAPLA

CLDN22

181

Q8N7P3
PLLHSICSACLEHSD

CTNNA3

216

Q9UI47
TLPCESTHHALLCCL

ADCY1

721

Q08828
HHQDCLPGTCCDLRE

DRAXIN

276

Q8NBI3
CDACISSYHIHCLNP

CHD3

471

Q12873
GDVLTFLDCHCECHE

GALNT12

221

Q8IXK2
HDCVDKSDEVNCSCH

CORIN

366

Q9Y5Q5
SAHSVTEDCLVPICC

LYST

2291

Q99698
QPQHSDCCEHESSRC

LCE7A

71

P0DV60
APHCEHAFCNACITQ

RNF41

31

Q9H4P4
HPDVHLCNCGKECNS

PRDM4

541

Q9UKN5
CKSHLLNCCPHDVLS

LUC7L2

36

Q9Y383
CHRCLKHTLATVPCD

SMYD4

296

Q8IYR2
EHEDVPICIHCSAGC

PTPN12

221

Q05209
HCEEVDCLDPTCSSH

TENM2

666

Q9NT68
RCEADHNECLSQPCH

NOTCH4

471

Q99466
ECASAPCLNHADCHD

NOTCH4

516

Q99466
CELLLHEHATVCCKD

SHANK2

281

Q9UPX8
CVEERICHLQHENPC

ANKRD20A12P

21

Q8NF67
SCSGSHHIKCCIEED

ADGRF5

581

Q8IZF2
SCKQALCPACDHLFH

RNF31

231

Q96EP0
CETDNDDCVAHKCRH

SLIT3

1071

O75094
CPRCSLSTDHQHHCV

TRIM61

116

Q5EBN2
VCCNPHHLSRLCELE

SMAD7

191

O15105
CHLVLCSPKQTECGH

TRAF3

56

Q13114
CQLIKPDRAHHCSAC

ZDHHC20

131

Q5W0Z9
PDRAHHCSACDSCIL

ZDHHC20

136

Q5W0Z9
SICDNCVERFDHHCP

ZDHHC9

156

Q9Y397
HCPVCDDLTQHGICS

REV3L

3041

O60673
LPRNHCDSCHCCRED

STOX2

191

Q9P2F5
CDSCHCCREDVHSTH

STOX2

196

Q9P2F5
CHEDTCDPVTGACHL

SCARF2

421

Q96GP6
CHICLVEHKTCSPAS

TRIM25

176

Q14258
CHLQLPSDECEHFET

FGD6

241

Q6ZV73
CCVCGDHSVALLHLE

WDR72

531

Q3MJ13
RKCHHLTCDLEDTCV

MYO18B

1576

Q8IUG5
SVCDNCVEEFDHHCP

ZDHHC5

121

Q9C0B5
SICNHCAVPDHSCEG

ZCCHC4

426

Q9H5U6
EECKQACICPSHLHS

ZNF57

171

Q68EA5
SVCDNCVEDFDHHCP

ZDHHC8

121

Q9ULC8
STHACACPLTDAECV

ZNF330

116

Q9Y3S2
CNDCGELFTCHSVHI

ZNF286B

246

P0CG31
HCLDYCESPTAHCNV

TENT5A

51

Q96IP4
DSIACGHQLIEHCCR

ZFYVE26

1946

Q68DK2
ICVCSHHTEGPSCER

LAMC3

721

Q9Y6N6
SCKCHPLGSQEDQCH

LAMC3

916

Q9Y6N6