Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	POU domain binding	POU5F1 POU5F1B	5.53e-05	7	33	2	GO:0070974
GeneOntologyMolecularFunction	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	POU5F1 POU5F1B	2.04e-04	13	33	2	GO:0001162
GeneOntologyMolecularFunction	intronic transcription regulatory region sequence-specific DNA binding	POU5F1 POU5F1B	3.55e-04	17	33	2	GO:0001161
GeneOntologyMolecularFunction	HMG box domain binding	POU5F1 POU5F1B	6.56e-04	23	33	2	GO:0071837
GeneOntologyMolecularFunction	lysine-acetylated histone binding	POU5F1 POU5F1B	1.12e-03	30	33	2	GO:0070577
GeneOntologyMolecularFunction	acetylation-dependent protein binding	POU5F1 POU5F1B	1.20e-03	31	33	2	GO:0140033
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	ADH5 PDHA1	2.85e-03	48	33	2	GO:0016620
GeneOntologyMolecularFunction	miRNA binding	POU5F1 POU5F1B	2.85e-03	48	33	2	GO:0035198
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the aldehyde or oxo group of donors	ADH5 PDHA1	3.86e-03	56	33	2	GO:0016903
GeneOntologyMolecularFunction	carbohydrate derivative transmembrane transporter activity	SLC25A47 SLC35A4	4.27e-03	59	33	2	GO:1901505
GeneOntologyMolecularFunction	nucleobase-containing compound transmembrane transporter activity	SLC25A47 SLC35A4	4.27e-03	59	33	2	GO:0015932
GeneOntologyMolecularFunction	regulatory RNA binding	POU5F1 POU5F1B	4.71e-03	62	33	2	GO:0061980
GeneOntologyMolecularFunction	actin filament binding	FLNA WDR1 KLHL17	6.15e-03	227	33	3	GO:0051015
GeneOntologyMolecularFunction	actin binding	KLHL2 FLNA WDR1 KLHL17	7.71e-03	479	33	4	GO:0003779
GeneOntologyBiologicalProcess	trophectodermal cell fate commitment	POU5F1 POU5F1B	6.99e-06	3	32	2	GO:0001830
GeneOntologyBiologicalProcess	ectodermal cell fate commitment	POU5F1 POU5F1B	2.33e-05	5	32	2	GO:0001712
GeneOntologyBiologicalProcess	ectoderm formation	POU5F1 POU5F1B	4.87e-05	7	32	2	GO:0001705
GeneOntologyBiologicalProcess	ectodermal cell differentiation	POU5F1 POU5F1B	8.34e-05	9	32	2	GO:0010668
GeneOntologyBiologicalProcess	germ-line stem cell population maintenance	POU5F1 POU5F1B	1.04e-04	10	32	2	GO:0030718
GeneOntologyBiologicalProcess	endodermal cell fate specification	POU5F1 POU5F1B	1.27e-04	11	32	2	GO:0001714
GeneOntologyBiologicalProcess	negative regulation of calcium ion-dependent exocytosis	POU5F1 POU5F1B	1.27e-04	11	32	2	GO:0045955
GeneOntologyBiologicalProcess	lipid catabolic process	GCDH ACAA2 OXCT1 GBA2 ALK	2.83e-04	382	32	5	GO:0016042
GeneOntologyBiologicalProcess	lipid modification	ADH5 GCDH ACAA2 GBA2	3.23e-04	214	32	4	GO:0030258
GeneOntologyBiologicalProcess	endodermal cell fate commitment	POU5F1 POU5F1B	3.51e-04	18	32	2	GO:0001711
GeneOntologyCellularComponent	male germ cell nucleus	POU5F1 POU5F1B TCFL5	3.35e-04	86	33	3	GO:0001673
GeneOntologyCellularComponent	germ cell nucleus	POU5F1 POU5F1B TCFL5	7.46e-04	113	33	3	GO:0043073
GeneOntologyCellularComponent	female germ cell nucleus	POU5F1 POU5F1B	1.09e-03	31	33	2	GO:0001674
GeneOntologyCellularComponent	mitochondrial matrix	GCDH ACAA2 OXCT1 PDHA1 ME3	1.28e-03	523	33	5	GO:0005759
Domain	POU_dom_5	POU5F1 POU5F1B	9.64e-06	3	34	2	IPR015585
Domain	POU	POU5F1 POU5F1B	3.80e-04	16	34	2	SM00352
Domain	POU_2	POU5F1 POU5F1B	3.80e-04	16	34	2	PS00465
Domain	Pou	POU5F1 POU5F1B	3.80e-04	16	34	2	PF00157
Domain	POU_dom	POU5F1 POU5F1B	3.80e-04	16	34	2	IPR000327
Domain	POU_3	POU5F1 POU5F1B	3.80e-04	16	34	2	PS51179
Domain	POU_1	POU5F1 POU5F1B	3.80e-04	16	34	2	PS00035
Domain	POU	POU5F1 POU5F1B	4.30e-04	17	34	2	IPR013847
Domain	-	POU5F1 POU5F1B	1.10e-03	27	34	2	1.10.260.40
Domain	-	KLHL2 KLHL17	1.10e-03	27	34	2	2.130.10.80
Domain	Aden_trnslctor	SLC25A47 SLC25A20	1.18e-03	28	34	2	IPR002113
Domain	Lambda_DNA-bd_dom	POU5F1 POU5F1B	1.27e-03	29	34	2	IPR010982
Domain	Gal_Oxidase_b-propeller	KLHL2 KLHL17	1.74e-03	34	34	2	IPR015916
Domain	BTB-kelch_protein	KLHL2 KLHL17	2.77e-03	43	34	2	IPR017096
Domain	SOLCAR	SLC25A47 SLC25A20	4.18e-03	53	34	2	PS50920
Domain	Mito_carr	SLC25A47 SLC25A20	4.18e-03	53	34	2	PF00153
Domain	-	SLC25A47 SLC25A20	4.18e-03	53	34	2	1.50.40.10
Domain	Mt_carrier_dom	SLC25A47 SLC25A20	4.18e-03	53	34	2	IPR023395
Domain	Mitochondrial_sb/sol_carrier	SLC25A47 SLC25A20	4.18e-03	53	34	2	IPR018108
Domain	Kelch	KLHL2 KLHL17	4.99e-03	58	34	2	SM00612
Domain	Gal_Oxase/kelch_b-propeller	KLHL2 KLHL17	5.16e-03	59	34	2	IPR011043
Domain	BACK	KLHL2 KLHL17	5.33e-03	60	34	2	SM00875
Domain	BACK	KLHL2 KLHL17	5.50e-03	61	34	2	PF07707
Domain	BACK	KLHL2 KLHL17	5.50e-03	61	34	2	IPR011705
Domain	Kelch_1	KLHL2 KLHL17	7.19e-03	70	34	2	PF01344
Domain	Kelch_1	KLHL2 KLHL17	7.19e-03	70	34	2	IPR006652
Pathway	KEGG_FATTY_ACID_METABOLISM	ADH5 GCDH ACAA2	5.40e-05	42	25	3	M699
Pathway	WP_MIRNAS_AND_TFS_IN_IPS_CELL_GENERATION	POU5F1 POU5F1B	8.40e-05	8	25	2	MM15855
Pathway	WP_KETOGENESIS_AND_KETOLYSIS	SLC25A20 OXCT1	8.40e-05	8	25	2	M39836
Pubmed	Genetic tool for fate mapping of Oct4 (Pou5f1)-expressing cells and their progeny past the pluripotency stage.	POU5F1 POU5F1B	9.28e-07	2	34	2	31843009
Pubmed	Characterization of novel alternative splicing variants of Oct4 gene expressed in mouse pluripotent stem cells.	POU5F1 POU5F1B	9.28e-07	2	34	2	29266259
Pubmed	The Effect of Melatonin on OCT4 Expression and Granulosa Cell Growth in Female Mice.	POU5F1 POU5F1B	9.28e-07	2	34	2	34735714
Pubmed	A unique developmental pattern of Oct-3/4 DNA methylation is controlled by a cis-demodification element.	POU5F1 POU5F1B	9.28e-07	2	34	2	12110668
Pubmed	OCT4 Silencing Triggers Its Epigenetic Repression and Impairs the Osteogenic and Adipogenic Differentiation of Mesenchymal Stromal Cells.	POU5F1 POU5F1B	9.28e-07	2	34	2	31277213
Pubmed	Changes in the Expression of Pluripotency Factor Oct-4 and Intensity of Apoptosis in the Uterus during Spontaneous and Immune-Dependent Abortions in Mice.	POU5F1 POU5F1B	9.28e-07	2	34	2	35501657
Pubmed	Identification of mouse blastocyst genes that are downregulated by double-stranded RNA-mediated knockdown of Oct-4 expression.	POU5F1 POU5F1B	9.28e-07	2	34	2	15685634
Pubmed	Nucleosome Clutches are Regulated by Chromatin Internal Parameters.	POU5F1 POU5F1B	9.28e-07	2	34	2	33181171
Pubmed	Hierarchical Oct4 Binding in Concert with Primed Epigenetic Rearrangements during Somatic Cell Reprogramming.	POU5F1 POU5F1B	9.28e-07	2	34	2	26832419
Pubmed	Regulatory Elements Outside Established Pou5f1 Gene Boundaries Are Required for Multilineage Differentiation of Embryonic Stem Cells.	POU5F1 POU5F1B	9.28e-07	2	34	2	37895112
Pubmed	Nuclear and chromatin reorganization in the MHC-Oct3/4 locus at developmental phases of embryonic stem cell differentiation.	POU5F1 POU5F1B	9.28e-07	2	34	2	16950240
Pubmed	Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes.	POU5F1 POU5F1B	9.28e-07	2	34	2	18837968
Pubmed	The homeodomain of Oct4 is a dimeric binder of methylated CpG elements.	POU5F1 POU5F1B	9.28e-07	2	34	2	36631980
Pubmed	[Investigation of transcriptional regulation of Oct4 (POU5F1) gene with distal enhancer].	POU5F1 POU5F1B	9.28e-07	2	34	2	25509123
Pubmed	Cruciform Formable Sequences within Pou5f1 Enhancer Are Indispensable for Mouse ES Cell Integrity.	POU5F1 POU5F1B	9.28e-07	2	34	2	33810223
Pubmed	Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin.	POU5F1 POU5F1B	9.28e-07	2	34	2	18063756
Pubmed	Oct4 was a novel target of Wnt signaling pathway.	POU5F1 POU5F1B	9.28e-07	2	34	2	22120493
Pubmed	Analysis of a transgenic Oct4 enhancer reveals high fidelity long-range chromosomal interactions.	POU5F1 POU5F1B	9.28e-07	2	34	2	26435056
Pubmed	Neural stem cells express Oct-3/4.	POU5F1 POU5F1B	9.28e-07	2	34	2	19664601
Pubmed	Distinct Enhancer Activity of Oct4 in Naive and Primed Mouse Pluripotency.	POU5F1 POU5F1B	9.28e-07	2	34	2	28157483
Pubmed	Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation.	POU5F1 POU5F1B	9.28e-07	2	34	2	9507072
Pubmed	Isolation of Oct4-expressing extraembryonic endoderm precursor cell lines.	POU5F1 POU5F1B	9.28e-07	2	34	2	19784378
Pubmed	Phosphorylation of Threonine343 Is Crucial for OCT4 Interaction with SOX2 in the Maintenance of Mouse Embryonic Stem Cell Pluripotency.	POU5F1 POU5F1B	9.28e-07	2	34	2	28988986
Pubmed	Abnormal DNA methylation of the Oct-4 enhancer region in cloned mouse embryos.	POU5F1 POU5F1B	9.28e-07	2	34	2	18932201
Pubmed	Oct-3/4 repression accelerates differentiation of neural progenitor cells in vitro and in vivo.	POU5F1 POU5F1B	9.28e-07	2	34	2	15548425
Pubmed	Genome-wide functional analysis reveals factors needed at the transition steps of induced reprogramming.	POU5F1 POU5F1B	9.28e-07	2	34	2	25043178
Pubmed	OCT4 interprets and enhances nucleosome flexibility.	POU5F1 POU5F1B	9.28e-07	2	34	2	36130732
Pubmed	A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo.	POU5F1 POU5F1B	9.28e-07	2	34	2	1972777
Pubmed	The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer.	POU5F1 POU5F1B	9.28e-07	2	34	2	1915274
Pubmed	Mouse Oct-3 maps between the tcl12 embryonic lethal gene and the Qa gene in the H-2 complex.	POU5F1 POU5F1B	9.28e-07	2	34	2	1680810
Pubmed	Computational analysis of single-cell transcriptomics data elucidates the stabilization of Oct4 expression in the E3.25 mouse preimplantation embryo.	POU5F1 POU5F1B	9.28e-07	2	34	2	31222057
Pubmed	Targeting of de novo DNA methylation throughout the Oct-4 gene regulatory region in differentiating embryonic stem cells.	POU5F1 POU5F1B	9.28e-07	2	34	2	20376339
Pubmed	Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue.	POU5F1 POU5F1B	9.28e-07	2	34	2	30653498
Pubmed	The molecular biology of Oct-4 in the early mouse embryo.	POU5F1 POU5F1B	9.28e-07	2	34	2	9835353
Pubmed	Effect of ploidy and parental genome composition on expression of Oct-4 protein in mouse embryos.	POU5F1 POU5F1B	9.28e-07	2	34	2	15183310
Pubmed	OCT4B mediates hypoxia-induced cancer dissemination.	POU5F1 POU5F1B	9.28e-07	2	34	2	30209362
Pubmed	Heterogeneous DNA methylation status of the regulatory element of the mouse Oct4 gene in adult somatic cell population.	POU5F1 POU5F1B	9.28e-07	2	34	2	15996113
Pubmed	POU5F1 Protein and Gene Expression Analysis in Neonate and Adult Mouse Testicular Germ Cells by Immunohistochemistry and Immunocytochemistry.	POU5F1 POU5F1B	9.28e-07	2	34	2	34788058
Pubmed	Dual roles of Oct4 in the maintenance of mouse P19 embryonal carcinoma cells: as negative regulator of Wnt/β-catenin signaling and competence provider for Brachyury induction.	POU5F1 POU5F1B	9.28e-07	2	34	2	21083502
Pubmed	A competitive protein interaction network buffers Oct4-mediated differentiation to promote pluripotency in embryonic stem cells.	POU5F1 POU5F1B	9.28e-07	2	34	2	24104477
Pubmed	Oct4 transcription factor in conjunction with valproic acid accelerates myelin repair in demyelinated optic chiasm in mice.	POU5F1 POU5F1B	9.28e-07	2	34	2	26804242
Pubmed	Conserved, developmentally regulated mechanism couples chromosomal looping and heterochromatin barrier activity at the homeobox gene A locus.	POU5F1 POU5F1B	9.28e-07	2	34	2	21502535
Pubmed	Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation.	POU5F1 POU5F1B	9.28e-07	2	34	2	17525163
Pubmed	Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells.	POU5F1 POU5F1B	9.28e-07	2	34	2	14990861
Pubmed	OCT4 Acts as an Integrator of Pluripotency and Signal-Induced Differentiation.	POU5F1 POU5F1B	9.28e-07	2	34	2	27499297
Pubmed	Identification of pulmonary Oct-4+ stem/progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro.	POU5F1 POU5F1B	9.28e-07	2	34	2	16772384
Pubmed	Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells.	POU5F1 POU5F1B	9.28e-07	2	34	2	11839818
Pubmed	Small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4.	POU5F1 POU5F1B	9.28e-07	2	34	2	24561253
Pubmed	Role of Organic Cation Transporter 3 and Plasma Membrane Monoamine Transporter in the Rewarding Properties and Locomotor Sensitizing Effects of Amphetamine in Male andFemale Mice.	POU5F1 POU5F1B	9.28e-07	2	34	2	34948221
Pubmed	Auxin-degron system identifies immediate mechanisms of OCT4.	POU5F1 POU5F1B	9.28e-07	2	34	2	34143975
Pubmed	Acidic extracellular pH of tumors induces octamer-binding transcription factor 4 expression in murine fibroblasts in vitro and in vivo.	POU5F1 POU5F1B	9.28e-07	2	34	2	27302093
Pubmed	Characterization of a negative retinoic acid response element in the murine Oct4 promoter.	POU5F1 POU5F1B	9.28e-07	2	34	2	8289793
Pubmed	Force via integrins but not E-cadherin decreases Oct3/4 expression in embryonic stem cells.	POU5F1 POU5F1B	9.28e-07	2	34	2	22037576
Pubmed	Long noncoding RNAs sustain high expression levels of exogenous octamer-binding protein 4 by sponging regulatory microRNAs during cellular reprogramming.	POU5F1 POU5F1B	9.28e-07	2	34	2	31624145
Pubmed	Dynamics and memory of heterochromatin in living cells.	POU5F1 POU5F1B	9.28e-07	2	34	2	22704655
Pubmed	Oct4 redox sensitivity potentiates reprogramming and differentiation.	POU5F1 POU5F1B	9.28e-07	2	34	2	38719541
Pubmed	A novel Oct4/Pou5f1-like non-coding RNA controls neural maturation and mediates developmental effects of ethanol.	POU5F1 POU5F1B	9.28e-07	2	34	2	33221301
Pubmed	Comparative analysis of human, bovine, and murine Oct-4 upstream promoter sequences.	POU5F1 POU5F1B	9.28e-07	2	34	2	11309664
Pubmed	Developmental fate of embryonic germ cells (EGCs), in vivo and in vitro.	POU5F1 POU5F1B	9.28e-07	2	34	2	12641567
Pubmed	Post-translational regulation of Oct4 transcriptional activity.	POU5F1 POU5F1B	9.28e-07	2	34	2	19221599
Pubmed	Small RNA-mediated regulation of iPS cell generation.	POU5F1 POU5F1B	9.28e-07	2	34	2	21285944
Pubmed	A nontranscriptional role for Oct4 in the regulation of mitotic entry.	POU5F1 POU5F1B	9.28e-07	2	34	2	25324523
Pubmed	A novel subpopulation lacking Oct4 expression in the testicular side population.	POU5F1 POU5F1B	9.28e-07	2	34	2	16328007
Pubmed	A unique Oct4 interface is crucial for reprogramming to pluripotency.	POU5F1 POU5F1B	9.28e-07	2	34	2	23376973
Pubmed	Oct4 kinetics predict cell lineage patterning in the early mammalian embryo.	POU5F1 POU5F1B	9.28e-07	2	34	2	21258368
Pubmed	Differential role for transcription factor Oct4 nucleocytoplasmic dynamics in somatic cell reprogramming and self-renewal of embryonic stem cells.	POU5F1 POU5F1B	9.28e-07	2	34	2	23580657
Pubmed	Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells.	POU5F1 POU5F1B	9.28e-07	2	34	2	17724450
Pubmed	Novel variants of Oct-3/4 gene expressed in mouse somatic cells.	POU5F1 POU5F1B	9.28e-07	2	34	2	18765667
Pubmed	Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells.	POU5F1 POU5F1B	9.28e-07	2	34	2	18283123
Pubmed	Transcriptional activation by Oct4 is sufficient for the maintenance and induction of pluripotency.	POU5F1 POU5F1B	9.28e-07	2	34	2	22832160
Pubmed	Gonadotropins affect Oct-4 gene expression during mouse oocyte growth.	POU5F1 POU5F1B	9.28e-07	2	34	2	16496425
Pubmed	De-differentiation of mouse interfollicular keratinocytes by the embryonic transcription factor Oct-4.	POU5F1 POU5F1B	9.28e-07	2	34	2	16932739
Pubmed	A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance.	POU5F1 POU5F1B	9.28e-07	2	34	2	24210613
Pubmed	Variable reprogramming of the pluripotent stem cell marker Oct4 in mouse clones: distinct developmental potentials in different culture environments.	POU5F1 POU5F1B	9.28e-07	2	34	2	15955835
Pubmed	Mechanisms of OCT4 on 3,5,3'-Tri-iodothyronine and FSH-induced Granulosa Cell Development in Female Mice.	POU5F1 POU5F1B	9.28e-07	2	34	2	34463738
Pubmed	Differential expression of Oct3/4 in human breast cancer and normal tissues.	POU5F1 POU5F1B	9.28e-07	2	34	2	29620155
Pubmed	[The dual role of OCT4].	POU5F1 POU5F1B	9.28e-07	2	34	2	20412747
Pubmed	Oct4 promoter activity in stem cells obtained through somatic reprogramming.	POU5F1 POU5F1B	9.28e-07	2	34	2	23550731
Pubmed	Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4.	POU5F1 POU5F1B	9.28e-07	2	34	2	27346346
Pubmed	The Octamer-Binding Transcription Factor 4 (OCT4) Pseudogene, POU Domain Class 5 Transcription Factor 1B (POU5F1B), is Upregulated in Cervical Cancer and Down-Regulation Inhibits Cell Proliferation and Migration and Induces Apoptosis in Cervical Cancer Cell Lines.	POU5F1 POU5F1B	9.28e-07	2	34	2	30762028
Pubmed	POU-V factors antagonize maternal VegT activity and beta-Catenin signaling in Xenopus embryos.	POU5F1 POU5F1B	9.28e-07	2	34	2	17541407
Pubmed	The long noncoding RNA Gm15055 represses Hoxa gene expression by recruiting PRC2 to the gene cluster.	POU5F1 POU5F1B	9.28e-07	2	34	2	26615201
Pubmed	Oct-4 is critical for survival/antiapoptosis of murine embryonic stem cells subjected to stress: effects associated with Stat3/survivin.	POU5F1 POU5F1B	9.28e-07	2	34	2	17932422
Pubmed	Global identification of transcriptional regulators of pluripotency and differentiation in embryonic stem cells.	POU5F1 POU5F1B	9.28e-07	2	34	2	22730289
Pubmed	Secondary structure of the oct-3 POU homeodomain as determined by 1H-15N NMR spectroscopy.	POU5F1 POU5F1B	9.28e-07	2	34	2	8097478
Pubmed	Identification of a homologue of POU5F1 (OCT3/4) in a marsupial, the brushtail possum.	POU5F1 POU5F1B	9.28e-07	2	34	2	11170265
Pubmed	Posttranscriptional regulation of maternal Pou5f1/Oct4 during mouse oogenesis and early embryogenesis.	POU5F1 POU5F1B	9.28e-07	2	34	2	32930837
Pubmed	Dissecting Oct3/4-regulated gene networks in embryonic stem cells by expression profiling.	POU5F1 POU5F1B	9.28e-07	2	34	2	17183653
Pubmed	A novel variant of Oct3/4 gene in mouse embryonic stem cells.	POU5F1 POU5F1B	9.28e-07	2	34	2	22683460
Pubmed	Sox transcription factors require selective interactions with Oct4 and specific transactivation functions to mediate reprogramming.	POU5F1 POU5F1B	9.28e-07	2	34	2	23963638
Pubmed	In silico tandem affinity purification refines an Oct4 interaction list.	POU5F1 POU5F1B	9.28e-07	2	34	2	21569470
Pubmed	Critical POU domain residues confer Oct4 uniqueness in somatic cell reprogramming.	POU5F1 POU5F1B	9.28e-07	2	34	2	26877091
Pubmed	The embryonic Octamer factor 3/4 displays distinct DNA binding specificity from those of other Octamer factors.	POU5F1 POU5F1B	9.28e-07	2	34	2	12615074
Pubmed	Novel epigenetic mechanisms that control pluripotency and quiescence of adult bone marrow-derived Oct4(+) very small embryonic-like stem cells.	POU5F1 POU5F1B	9.28e-07	2	34	2	19641521
Pubmed	OCT4 expression mediates partial cardiomyocyte reprogramming of mesenchymal stromal cells.	POU5F1 POU5F1B	9.28e-07	2	34	2	29216265
Pubmed	Effect of ectopic expression of homeoprotein EGAM1C on the cell morphology, growth, and differentiation in a mouse embryonic stem cell line, MG1.19 cells.	POU5F1 POU5F1B	9.28e-07	2	34	2	22367590
Pubmed	Induction of pluripotent stem cells from adult somatic cells by protein-based reprogramming without genetic manipulation.	POU5F1 POU5F1B	9.28e-07	2	34	2	20439621
Pubmed	Loss of Oct4 expression during the development of murine embryoid bodies.	POU5F1 POU5F1B	9.28e-07	2	34	2	22960235
Pubmed	Rewirable gene regulatory networks in the preimplantation embryonic development of three mammalian species.	POU5F1 POU5F1B	9.28e-07	2	34	2	20219939
Pubmed	Oct4 distribution and level in mouse clones: consequences for pluripotency.	POU5F1 POU5F1B	9.28e-07	2	34	2	12023300
GeneFamily	POU class homeoboxes and pseudogenes	POU5F1 POU5F1B	3.20e-04	23	21	2	523
GeneFamily	Solute carriers	SLC25A47 SLC25A20 SLC11A1 SLC35A4	1.00e-03	395	21	4	752
GeneFamily	Kelch like\|BTB domain containing	KLHL2 KLHL17	1.08e-03	42	21	2	617
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KLHL2 KLHL17	1.04e-02	134	21	2	861
Coexpression	MOOTHA_HUMAN_MITODB_6_2002	GCDH ACAA2 SLC25A20 OXCT1 PDHA1 ME3	1.76e-05	432	34	6	M9433
Coexpression	BYSTRYKH_HEMATOPOIESIS_STEM_CELL_FGF3	POU5F1 POU5F1B	5.85e-05	9	34	2	MM608
Coexpression	TESAR_ALK_AND_JAK_TARGETS_MOUSE_ES_D4_DN	POU5F1 POU5F1B	7.30e-05	10	34	2	MM741
Coexpression	GSE14000_UNSTIM_VS_16H_LPS_DC_UP	PFAS IL16 GBA2 TCFL5	1.20e-04	197	34	4	M3348
Coexpression	GSE17974_CTRL_VS_ACT_IL4_AND_ANTI_IL12_48H_CD4_TCELL_DN	ACAA2 SLC25A20 PDHA1 KLHL17	1.25e-04	199	34	4	M4200
Coexpression	GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_UP	ACAA2 SLC25A20 FAM120A GBA2	1.28e-04	200	34	4	M7742
Coexpression	GSE5589_LPS_AND_IL10_VS_LPS_AND_IL6_STIM_IL6_KO_MACROPHAGE_45MIN_DN	MFSD14A FLNA ACAA2 SLC11A1	1.28e-04	200	34	4	M6626
ToppCell	droplet-Liver-hepatocytes-3m-Epithelial-Hepatocyte_(Midlobular)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADH5 GCDH ACAA2 SLC25A47	5.51e-06	153	34	4	d9e2c386875bc15e1e6e75dc7acf05c0dc8c306b
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Mesenchymal-Cilia-bearing_cell\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	PFAS FAM120A SLC11A1 SHISA7	7.25e-06	164	34	4	346e1530b4bf30adbcb2f7d64fdfb4cd8df69d7f
ToppCell	facs-Liver-Non-hepatocytes-3m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADH5 GCDH ACAA2 SLC25A47	8.75e-06	172	34	4	feaaf8ca7983d04a59ed0a7b3fb0e6d4b3a055f2
ToppCell	facs-Liver-Non-hepatocytes-3m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADH5 GCDH ACAA2 SLC25A47	8.75e-06	172	34	4	9adfb4a65669cc536343616637058d0a4728013f
ToppCell	facs-Liver-Non-hepatocytes-3m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADH5 GCDH ACAA2 SLC25A47	8.75e-06	172	34	4	8aed9c113f27d00401c272a3684495a4bc75bd0f
Drug	n-propionyl-CoA	GCDH ACAA2 SLC25A20 OXCT1 PDHA1	4.55e-06	166	34	5	CID000001033
Drug	succinyl-coenzyme A	GCDH ACAA2 OXCT1 PDHA1 ME3	4.55e-06	166	34	5	CID000001111
Drug	AC1L975Q	GCDH ACAA2 OXCT1	6.03e-06	24	34	3	CID000439337
Drug	AC1L2LUF	GCDH OXCT1	1.30e-05	4	34	2	CID000074406
Drug	AC1Q68Z5	GCDH ACAA2 SLC25A20 OXCT1 PDHA1 ME3	2.06e-05	386	34	6	CID000000181
Drug	AC1L1GAZ	GCDH ACAA2 OXCT1	3.60e-05	43	34	3	CID000003605
Drug	butyraldehyde	ADH5 ACAA2 OXCT1	5.03e-05	48	34	3	CID000000261
Drug	1-butyl-3-methylimidazolium	ADH5 SLC25A20	6.03e-05	8	34	2	CID002734161
Drug	glutaconyl-CoA	GCDH OXCT1	6.03e-05	8	34	2	CID009543049
Drug	AC1MI0E8	GCDH ACAA2	6.03e-05	8	34	2	CID003036008
Drug	potassium persulfate	ADH5 TCFL5	6.03e-05	8	34	2	CID000024412
Drug	CPD-226	GCDH OXCT1	7.74e-05	9	34	2	CID000439705
Drug	3-Hydroxybutanoyl-Coenzyme A	GCDH ACAA2 OXCT1	8.42e-05	57	34	3	CID000000521
Drug	zearalanone	TCFL5 ALK	1.18e-04	11	34	2	CID000108003
Drug	AC1L193Y	GCDH ACAA2 SLC25A20	1.25e-04	65	34	3	CID000000380
Drug	beta-hydroxybutyrate	ACAA2 OXCT1 PDHA1 ME3	1.42e-04	179	34	4	CID000000441
Drug	reduced diphosphopyridine nucleotide	ADH5 GCDH ACAA2 PDHA1 ME3	1.44e-04	342	34	5	CID000000928
Drug	octanoate	ADH5 ACAA2 SLC25A20 PDHA1	1.49e-04	181	34	4	CID000000379
Drug	Betaxolol hydrochloride [63659-19-8]; Up 200; 11.6uM; MCF7; HT_HG-U133A	RHBDL1 ACAA2 SLC11A1 ALK	2.02e-04	196	34	4	3208_UP
Drug	PNU-0230031 [267429-39-0]; Up 200; 1uM; MCF7; HT_HG-U133A	IL16 SLC11A1 BFSP2 ALK	2.06e-04	197	34	4	4757_UP
Drug	AC1Q68ZE	GCDH ACAA2 OXCT1	2.23e-04	79	34	3	CID000000265
Drug	N,N'-methylenebisacrylamide	ADH5 IL16	2.25e-04	15	34	2	CID000008041
Drug	3-ketoadipyl-CoA	ACAA2 OXCT1	2.25e-04	15	34	2	CID000000094
Drug	3-hydroxyoctanoate	ACAA2 ALK	2.25e-04	15	34	2	CID000026613
Drug	CO(2	ADH5 RHBDL1 GCDH PDHA1 ME3	2.30e-04	378	34	5	CID000000280
Drug	acetate	ADH5 SLC25A20 OXCT1 PDHA1 GBA2 ME3	2.32e-04	599	34	6	CID000000175
Disease	L-arginine measurement	GCDH PDHA1	3.69e-04	27	31	2	EFO_0006524
Disease	Osteoporosis, Age-Related	OXCT1 WDR1	1.88e-03	61	31	2	C0001787
Disease	Post-Traumatic Osteoporosis	OXCT1 WDR1	1.88e-03	61	31	2	C0751406
Disease	Osteoporosis, Senile	OXCT1 WDR1	1.88e-03	61	31	2	C0029459
Disease	Osteoporosis	OXCT1 WDR1	2.00e-03	63	31	2	C0029456

Protein segments in the cluster

Peptide	Gene	Start	Entry
YTAGPGACGLGAVGQ	C1orf167	751	Q5SNV9
PGSVCAVFGLGGVGL	ADH5	191	P11766
VYVGTAPSGCIGGLG	BFSP2	56	Q13515
VGAIAGAGILYGVAP	AQP5	96	P55064
GGMAYCGPQVGVGLV	POU5F1B	71	Q06416
AVITPYGECILGAGG	EDEM2	456	Q9BV94
EAGVGLGIGLCSVPY	IL16	361	Q14005
AGGFGGVCLVFVGHP	SLC25A20	16	O43772
YQGGVILGCLFGPAA	SLC11A1	346	P49279
VCGFGGPYGETVATG	FAM120A	891	Q9NZB2
GIRGLCNGLGPALYG	MFSD14A	376	Q96MC6
GGMAYCGPQVGVGLV	POU5F1	71	Q01860
RCEGAGPVLFAVGGG	KLHL17	336	Q6TDP4
GELGVLGPTIKGYGC	GCDH	101	Q92947
LRQIYGCPLGGIGGG	GBA2	146	Q9HCG7
SGVQCYGPGIEGQGV	FLNA	1256	P21333
ILGLGDLGCYGMGIP	ME3	191	Q16798
YVVPVGGVRAGLCGQ	C19orf54	326	Q5BKX5
PGCLDGGGVQYLLVG	RTP5	36	Q14D33
AVCIGILPGLGAYSG	PSME3IP1	206	Q9GZU8
GVVGCVIILNFGGGY	MT-ND6	36	P03923
RGGEGPGGSTAYVVC	SHISA7	176	A6NL88
GAIGGVCGVAVGYPL	SLC25A47	6	Q6Q0C1
GPGGYAVVVCIGQIV	WDR1	416	O75083
GATVLVGGFGLCGIP	OXCT1	56	P55809
APVVGGSGGVYALCS	RHBDL1	306	O75783
VPLIIAAGGGGRAYG	ALK	836	Q9UM73
YAVGSACIGGGQGIA	ACAA2	376	P42765
YGGNGIVGAQVPLGA	PDHA1	161	P08559
GAGPLCVLGGAALGV	TMIE	6	Q8NEW7
KVGGPVYRIGVGGGA	PFAS	451	O15067
AAGACYAAGGLQVPG	SLC35A4	151	Q96G79
AGGQGGAAPVYPVLC	TCFL5	96	Q9UL49
CDGLGQVVGEYKGPG	TRIM56	661	Q9BRZ2
ELIPGGAGIVVGYGD	HECTD3	681	Q5T447
GVGVVGGLLYAVGGY	KLHL2	441	O95198