Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

RNF34 BIRC2 PTPN22 ERBIN

2.07e-0730364GO:0035872
GeneOntologyBiologicalProcessregulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

BIRC2 PTPN22 ERBIN

2.69e-0616363GO:0070424
GeneOntologyBiologicalProcessnegative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

PTPN22 ERBIN

1.77e-054362GO:0070433
GeneOntologyBiologicalProcessnegative regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

PTPN22 ERBIN

1.77e-054362GO:0070425
GeneOntologyBiologicalProcesspositive regulation of protein K63-linked ubiquitination

BIRC2 PTPN22

8.24e-058362GO:1902523
GeneOntologyBiologicalProcessdopaminergic neuron differentiation

NR4A2 PHOX2B TIAM1

9.05e-0550363GO:0071542
GeneOntologyBiologicalProcessnoradrenergic neuron differentiation

SOX4 PHOX2B

1.61e-0411362GO:0003357
GeneOntologyBiologicalProcessregulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

PTPN22 ERBIN

1.61e-0411362GO:0070432
GeneOntologyBiologicalProcessregulation of protein K63-linked ubiquitination

BIRC2 PTPN22

2.66e-0414362GO:1900044
GeneOntologyBiologicalProcesspeptide hormone secretion

SOX4 PLCB1 TIAM1 PCLO MADD

2.70e-04334365GO:0030072
GeneOntologyBiologicalProcesspeptide secretion

SOX4 PLCB1 TIAM1 PCLO MADD

3.05e-04343365GO:0002790
GeneOntologyBiologicalProcesscytoplasmic pattern recognition receptor signaling pathway

RNF34 BIRC2 PTPN22 ERBIN

3.13e-04188364GO:0002753
GeneOntologyBiologicalProcesspeptide transport

SOX4 PLCB1 TIAM1 PCLO MADD

3.57e-04355365GO:0015833
GeneOntologyBiologicalProcessneuron migration

NR4A2 CCR4 PHOX2B NEXMIF

5.48e-04218364GO:0001764
GeneOntologyBiologicalProcesspositive regulation of protein polyubiquitination

BIRC2 PTPN22

5.52e-0420362GO:1902916
GeneOntologyBiologicalProcessnucleotide-binding oligomerization domain containing 2 signaling pathway

PTPN22 ERBIN

5.52e-0420362GO:0070431
GeneOntologyBiologicalProcessrespiratory gaseous exchange by respiratory system

NR4A2 PHOX2B SELENON

5.69e-0493363GO:0007585
GeneOntologyBiologicalProcessresponse to muramyl dipeptide

PTPN22 ERBIN

6.09e-0421362GO:0032495
GeneOntologyBiologicalProcessprotein K48-linked ubiquitination

RNF34 BIRC2 UBR4

7.03e-04100363GO:0070936
GeneOntologyBiologicalProcessintracellular receptor signaling pathway

NR4A2 RNF34 BIRC2 PTPN22 ERBIN

7.34e-04416365GO:0030522
GeneOntologyBiologicalProcesshormone secretion

SOX4 PLCB1 TIAM1 PCLO MADD

7.66e-04420365GO:0046879
GeneOntologyBiologicalProcessamide transport

SOX4 PLCB1 TIAM1 PCLO MADD

7.66e-04420365GO:0042886
GeneOntologyBiologicalProcesssympathetic nervous system development

SOX4 PHOX2B

7.98e-0424362GO:0048485
GeneOntologyBiologicalProcesshormone transport

SOX4 PLCB1 TIAM1 PCLO MADD

8.69e-04432365GO:0009914
GeneOntologyBiologicalProcessregulation of respiratory gaseous exchange

NR4A2 PHOX2B

1.01e-0327362GO:0043576
GeneOntologyBiologicalProcessinsulin secretion

SOX4 PLCB1 TIAM1 PCLO

1.28e-03274364GO:0030073
GeneOntologyBiologicalProcessregulation of peptide hormone secretion

SOX4 PLCB1 TIAM1 MADD

1.34e-03277364GO:0090276
GeneOntologyBiologicalProcessprotein secretion

SOX4 PLCB1 TIAM1 PCLO MADD

1.39e-03480365GO:0009306
GeneOntologyBiologicalProcessregulation of protein polyubiquitination

BIRC2 PTPN22

1.42e-0332362GO:1902914
GeneOntologyBiologicalProcessregulation of peptide transport

SOX4 PLCB1 TIAM1 MADD

1.43e-03282364GO:0090087
GeneOntologyBiologicalProcessregulation of peptide secretion

SOX4 PLCB1 TIAM1 MADD

1.43e-03282364GO:0002791
GeneOntologyBiologicalProcessestablishment of protein localization to extracellular region

SOX4 PLCB1 TIAM1 PCLO MADD

1.43e-03483365GO:0035592
GeneOntologyBiologicalProcessregulation of cytoplasmic pattern recognition receptor signaling pathway

BIRC2 PTPN22 ERBIN

1.47e-03129363GO:0039531
GeneOntologyBiologicalProcessprotein localization to extracellular region

SOX4 PLCB1 TIAM1 PCLO MADD

1.52e-03490365GO:0071692
GeneOntologyBiologicalProcessprotein polyubiquitination

RNF34 BIRC2 PTPN22 UBR4

1.56e-03289364GO:0000209
GeneOntologyBiologicalProcesspositive regulation of response to external stimulus

RNF34 BIRC2 PTPN22 CCR4 TIAM1 ERBIN

1.60e-03738366GO:0032103
GeneOntologyBiologicalProcesshematopoietic stem cell homeostasis

SOX4 TET2

1.60e-0334362GO:0061484
GeneOntologyBiologicalProcesspattern recognition receptor signaling pathway

RNF34 BIRC2 PTPN22 ERBIN

1.66e-03294364GO:0002221
GeneOntologyCellularComponentnuclear speck

NR4A2 POLI PLCB1 RNF34 SRRM2 ERBIN

1.00e-04431376GO:0016607
HumanPhenoDecreased heart rate variability

PHOX2B MADD

3.14e-053172HP:0031861
HumanPhenoHip contracture

KAT6B SELENON F8 GNPAT

4.21e-0562174HP:0003273
DomainZnf_FYVE_PHD

RNF34 KAT6B PCLO

3.05e-03147373IPR011011
DomainPDZ

TIAM1 ERBIN PCLO

3.29e-03151373PS50106
DomainPDZ

TIAM1 ERBIN PCLO

3.35e-03152373IPR001478
DomainPH_dom-like

PLCB1 TIAM1 NSMAF AFAP1L1

9.73e-03426374IPR011993
PathwayPID_TNF_PATHWAY

BIRC2 MADD NSMAF

1.01e-0446283M128
PathwayREACTOME_TNF_SIGNALING

BIRC2 MADD NSMAF

1.81e-0456283MM15453
PathwayREACTOME_TNF_SIGNALING

BIRC2 MADD NSMAF

1.91e-0457283M27713
PathwayREACTOME_DEATH_RECEPTOR_SIGNALING

BIRC2 TIAM1 MADD NSMAF

2.29e-04154284M27697
Pubmed

De Novo Variants in CNOT1, a Central Component of the CCR4-NOT Complex Involved in Gene Expression and RNA and Protein Stability, Cause Neurodevelopmental Delay.

NR4A2 CCR4

3.30e-06337232553196
Pubmed

Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome.

NR4A2 TET2

1.65e-05637227694924
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

TET2 UBAP2 TIAM1 SRRM2 ERBIN EDRF1 MADD

3.00e-0586137736931259
Pubmed

Striking parallels between carotid body glomus cell and adrenal chromaffin cell development.

SOX4 PHOX2B

3.07e-05837229807017
Pubmed

Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system.

SOX4 PHOX2B

6.02e-051137220147379
Pubmed

Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth.

RNF34 BIRC2

7.22e-051237215069192
Pubmed

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression.

SOX4 BIRC2

1.48e-041737220080598
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

KAT6B SRRM2 MADD

1.87e-041043739205841
Pubmed

A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons.

CCR4 PHOX2B

2.28e-042137216129397
Pubmed

Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain.

NR4A2 PHOX2B

2.28e-042137211500373
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SERTAD2 PLCB1 TET2 UBAP2 KAT6B

2.33e-0452937514621295
Pubmed

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

TET2 KAT6B TIAM1 ERBIN USP32

2.48e-0453637515840001
Pubmed

Exchangeable gene trap using the Cre/mutated lox system.

TET2 KAT6B TIAM1 ERBIN USP32

2.52e-0453837510512203
Pubmed

OTUB1 modulates c-IAP1 stability to regulate signalling pathways.

BIRC2 UBR4

2.99e-042437223524849
Pubmed

Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development.

NR4A2 PHOX2B

3.52e-042637221752929
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

NR4A2 TET2 BIRC2 TIAM1 MADD UBR4 USP32

3.60e-04128537735914814
Pubmed

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

UBAP2 SRRM2 ERBIN

3.86e-0413337315144186
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

KAT6B SRRM2 ERBIN UBR4

4.65e-0434137432971831
Pubmed

Gene expression in the developing mouse retina by EST sequencing and microarray analysis.

GCDH MADD GNPAT

4.68e-0414237311812828
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

PLCB1 SRRM2 PCLO MADD

4.96e-0434737417114649
Pubmed

Wnt1-cre-mediated conditional loss of Dicer results in malformation of the midbrain and cerebellum and failure of neural crest and dopaminergic differentiation in mice.

NR4A2 PHOX2B

5.02e-043137220457670
Pubmed

SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.

TET2 BIRC2 UBAP2 SRRM2

5.29e-0435337427545878
Pubmed

Distinct expression of select and transcriptome-wide isolated 3'UTRs suggests critical roles in development and transition states.

NR4A2 SOX4

5.69e-043337233951080
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

PTPN22 SHROOM1 SRRM2 UBR4

5.75e-0436137426167880
Pubmed

CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression.

NR4A2 PLCB1 CCR4

6.99e-0416337323333304
Pubmed

Endothelial Cyp26b1 restrains murine heart valve growth during development.

SOX4 SHROOM1 AFAP1L1

6.99e-0416337335364055
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

NR4A2 GCDH MADD UBR4 AFAP1L1

7.76e-0468937536543142
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

SERTAD2 NR4A2 SOX4 PHOX2B KAT6B

8.82e-0470937522988430
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SRRM2 SETD5 ERBIN MADD

8.99e-0440737412693553
Cytoband1p36.13

SELENON UBR4

9.47e-04563721p36.13
GeneFamilyPDZ domain containing

TIAM1 ERBIN PCLO

1.17e-031522531220
CoexpressionGSE41867_DAY15_EFFECTOR_VS_DAY30_MEMORY_CD8_TCELL_LCMV_ARMSTRONG_DN

SERTAD2 PTPN22 UBAP2 CENPL USP32

6.86e-06190375M9521
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TET2 RNASE1 SRRM2 NSMAF UBR4

6.25e-07199375379bbd9cecf466b902411c54d74bd9885285b1ba
ToppCellCV-Mild-7|CV / Virus stimulation, Condition and Cluster

POLI CENPL EDRF1 NSMAF

1.18e-0517037425ebde7d2f8ae1afdfaf5876284ff20bb179eb10
ToppCellCV-Mild-7|Mild / Virus stimulation, Condition and Cluster

TET2 CENPL EDRF1 NSMAF

1.26e-05173374c9bbca9313a0fdf146c8c995624b94b937e818d8
ToppCellE12.5-Epithelial-epithelial_progenitor_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PHOX2B NEXMIF LAD1 AFAP1L1

1.71e-05187374ab6f4d387218b4651fdadbf269806c1ddc96a1d2
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

PLCB1 SRRM2 SETD5 ERBIN

1.94e-05193374e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellSevere-CD8+_T|World / Disease group and Cell class

PLCB1 RNASE1 LAD1

2.06e-05643733e7ede6ec5d8b9c4fc6f3aa8fda91fd9b763ef18
ToppCellwk_15-18-Endothelial-Lymph_endothelial|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SELENON F8 PCLO AFAP1L1

2.06e-05196374ff627244d7f5fd6a2ec009dae32d3509f0e2d95e
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NR4A2 RNASE1 SRRM2 UBR4

2.19e-05199374667b8b47a5b388506e3177b46747267fad8024f6
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-regulatory_T_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CCR4 TIAM1 CENPL

2.40e-041463737748277cf2f12e2930d4f5a22247ab9bc266a954
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3|TCGA-Brain / Sample_Type by Project: Shred V9

SOX4 SETD5 UBR4

2.55e-04149373768877bade04ca0321593b8470b5011ad8270431
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Lymphocytic-T_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN22 CCR4 MADD

2.91e-041563730bd32876413f3308f838f266e8c39ea0937ce5b9
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

RNASE1 IQCJ-SCHIP1 F8

2.97e-041573734183dbed6b31ebe13ef33eb19ba6d0fb4f625953
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

RNASE1 IQCJ-SCHIP1 F8

3.02e-04158373de65af8d3b8514b17978155f31975e2347b75251
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCR4 RNASE1 TIAM1

3.14e-0416037333050dc646762dc7e9dcc4a12c618e1ba1ce5a4d
ToppCell10x3'2.3-week_14-16-Myeloid_macrophage-stroma-erythroid_macrophage|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

NR4A2 RNASE1 NEXMIF

3.31e-04163373240d9f0ea45e8b2c7173e7674fd740555810f9e7
ToppCellSevere-Lymphoid-NK-CCR7+_T|Severe / Condition, Lineage, Cell class and cell subclass

PTPN22 CCR4 GNPAT

3.31e-041633738f0d8c124f1569a5a6bc1db7581989f24d63cca3
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SRRM2 PCLO MADD

3.49e-0416637366026988509e39e41274fa0de738383219e8ff30
ToppCelldroplet-Heart-nan-24m-Hematologic-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHROOM1 PCDHGA2 MADD

3.56e-04167373bad33497ceeab968a7eb8a48b921c6f936390743
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP3_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

NR4A2 CCR4 PHOX2B

3.68e-04169373d9c3b22f62b882b8a2ea6fd9cf7afbe6d1775745
ToppCellControl-CD4+_T|World / Disease group and Cell class

PLCB1 CCR4 NEXMIF

3.68e-04169373e330d85bd37a1bd1c3d8d29ddd8a2c1020a62a83
ToppCell368C-Lymphocytic-NK_cells-NK_cell_E|368C / Donor, Lineage, Cell class and subclass (all cells)

SOX4 PTPN22 PCLO

3.68e-041693730d96c0b4fd26fbc0bf44ff7bed2936eebcc55b74
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SELENON F8 AFAP1L1

3.75e-041703734848965bc7e9356c6601bb41eeea1553d2eea87e
ToppCelldroplet-Liver-HEPATOCYTES-1m-Lymphocytic-NK/T|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POLI RNF34 PTPN22

3.81e-041713732e7cc311005958af52f39ca6c310c85b43a85aaf
ToppCell5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLCB1 F8 AFAP1L1

3.81e-04171373b3e6e31dfe3623b960ccf692fdbd236fa4039923
ToppCelldroplet-Kidney-nan-21m-Lymphocytic-CD45____T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NR4A2 PTPN22 CCR4

3.81e-041713731176577841bb6cff27ca288e0c89d2e2242efbb3
ToppCelldroplet-Liver-HEPATOCYTES-1m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POLI RNF34 PTPN22

3.81e-041713734b599f953c8e5b947b2c8bbbf7fe6f9dc388e336
ToppCelldroplet-Kidney-nan-21m-Lymphocytic-T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NR4A2 PTPN22 CCR4

3.88e-041723736c7d03393a60dab954054e34ea842cc77412eb19
ToppCellCOPD-Lymphoid-ILC_A|Lymphoid / Disease state, Lineage and Cell class

SOX4 PLCB1 TIAM1

3.94e-041733734a0043b29f8ede5a74bdb38cbf2c70e12b25e130
ToppCell5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE1 MADD AFAP1L1

4.01e-0417437342735f6a8e5ec36dd3d35aceea6d37cf3eaa1871
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLCB1 RNASE1 F8

4.01e-0417437318ab52d8bbca0507fee220e0c4fc765fc47dda34
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RNASE1 MADD UBR4

4.01e-04174373d77fa525d5c87c190b4a10787b270eabd16c610f
ToppCellIPF-Lymphoid-ILC_A|Lymphoid / Disease state, Lineage and Cell class

SOX4 PLCB1 TIAM1

4.08e-04175373b6d1e40d9339426d778481fd67ab7cbc0f6cb5b2
ToppCell356C-Myeloid-Dendritic-cDC_proliferating_2|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

RNF34 RNASE1 NEXMIF

4.08e-041753737de1023161233b64f11e130881c742f4cf2bff65
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SERTAD2 BIRC2 GCDH

4.15e-0417637391ad2c34144f72283ca112fd3b3784f2f6259f65
ToppCelldroplet-Kidney-nan-21m-Lymphocytic-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NR4A2 PTPN22 RNASE1

4.15e-04176373feafc757e7aa4f17128ff34886beb2fd3461c9ea
ToppCellControl|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SOX4 RNASE1 AFAP1L1

4.22e-04177373b8ff6940e31b749776e81ae4f5bbd577dba9749c
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Lymphocytic-T_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN22 CCR4 MADD

4.22e-041773739d2d70d53b919fed3328812889a55e5e1a0759de
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel-D175|Adult / Lineage, Cell type, age group and donor

PLCB1 SELENON AFAP1L1

4.22e-04177373c9f269765c7d5d29caab75910e51645606ed562e
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX4 RNASE1 PHOX2B

4.29e-04178373a9ba4089413b1c55d667ce836b6972ca572ee2b8
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX4 RNASE1 PHOX2B

4.29e-0417837313dfd28a80889c2dacdc65b94a41bb9762dc409d
ToppCellPCW_13-14-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

RNASE1 SHROOM1 AFAP1L1

4.29e-04178373c227da59dc7beb73f84405bf13356bdeb59d9338
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

PLCB1 SHROOM1 F8

4.36e-041793731ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Lymphocytic-T_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN22 CENPL MADD

4.36e-041793738bf04a7ad1b0be6722ebfdceba3f083f07bf96c5
ToppCell3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NR4A2 F8 AFAP1L1

4.36e-04179373ec1d7017da325647b629de703135a404bbdc627d
ToppCellILEUM-non-inflamed-(7)_Lymphatics|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

F8 PCLO AFAP1L1

4.36e-0417937399777a8931356d1206b8ab22aaa1b1d5a600b809
ToppCellCOVID-19-kidney-PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

PLCB1 F8 AFAP1L1

4.43e-04180373493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCellP15-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SOX4 PLCB1 AFAP1L1

4.43e-04180373410ea13a9c00cf54b4d47c72404dfe893c086d87
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLCB1 RNASE1 AFAP1L1

4.43e-0418037397e0dcb7cfbba60a782824c5e23995058609fcd4
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)-|367C / Donor, Lineage, Cell class and subclass (all cells)

F8 PCLO AFAP1L1

4.50e-04181373b244ecaa442bbef51289d8ec574ef08fa9e96318
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX4 PHOX2B PCLO

4.50e-041813737f99002a6411117cc2361334c7c9228e20c574b4
ToppCellControl_saline-Hematopoietic_Myeloid-Dendritic_cells-mDC|Control_saline / Treatment groups by lineage, cell group, cell type

NAT1 PTPN22 LAD1

4.50e-04181373818ac31a718e9b29feb4c4eecbc339e6af45254a
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE1 PHOX2B PCLO

4.50e-04181373fb4df9a128761abe5c6310a30d7b2f7f2fdef46d
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)|367C / Donor, Lineage, Cell class and subclass (all cells)

F8 PCLO AFAP1L1

4.50e-04181373dd79de8098edb385a0f85d0e9621503cdf76ec43
ToppCellCOVID-19-Heart-EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

PLCB1 MUC3A F8

4.57e-04182373e67f3234165199085c793915ebb1f9bbd845e933
ToppCellE12.5-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NEXMIF LAD1 AFAP1L1

4.57e-04182373204530444e35d4977a7239ac176f477e9e5c29ab
ToppCellCOVID-19-kidney-Mito-rich_EC|kidney / Disease (COVID-19 only), tissue and cell type

PLCB1 F8 AFAP1L1

4.65e-041833733c4153479fc4ab2d073d92cee120480015555914
ToppCellCOVID-19_Mild-gd_T|COVID-19_Mild / Disease condition and Cell class

PLCB1 ERBIN LAD1

4.65e-04183373f593a89b0aa8fffdfa403769916facfd30358521
ToppCellE12.5-Epithelial-epithelial_progenitor_cell-epi_progenitor|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NEXMIF LAD1 AFAP1L1

4.65e-04183373031b4ffd95114dc10d2932c67d2cfef139b3fd2e
ToppCelldroplet-Limb_Muscle-nan-21m-Lymphocytic-T_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN22 CCR4 MADD

4.65e-04183373ac70a6ec9270b1bfe089702262d4575a6c42afb4
ToppCellHSPCs-LMPPs|World / Lineage and Cell class

NR4A2 SOX4 AFAP1L1

4.65e-04183373e401f06843528a75693ce455bbeff2a98b8c24e5
ToppCell10x5'v1-week_17-19-Lymphocytic_T-T_NK-Treg|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

NR4A2 CCR4 NSMAF

4.65e-041833735fb933acfe6bc555c90dba71e75d4be658763945
ToppCellParenchymal-10x3prime_v2-Immune_Lymphocytic-T-T_CD8-CD8_TRM|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NR4A2 PTPN22 CENPL

4.72e-0418437317ffa0e890960c00a3b5fa33d48caba66c61dbb0
ToppCellPCW_10-12-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

RNASE1 SHROOM1 AFAP1L1

4.72e-04184373a809b0fa52df8a159f60f87eefcef61220af5e34
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like|lymph-node_spleen / Manually curated celltypes from each tissue

SOX4 PLCB1 AFAP1L1

4.72e-04184373d97471a4fe17cba6880ccf1a04cc00c741558124
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NR4A2 TET2 RNASE1

4.72e-04184373d1ea2b60fb1ca1a0b809d131310c43903a9e84ce
ToppCellControl-Lymphoid-T_Regulatory|Lymphoid / Disease state, Lineage and Cell class

TET2 CCR4 TIAM1

4.79e-04185373e481cacda0b6b25f5f0062b962df9a442053ac30
ToppCellCOVID-19-Endothelial_cells-Systemic_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

PLCB1 F8 AFAP1L1

4.79e-04185373f5e14181f45c37d13ee9e017a4c8bc248c353676
ToppCellnucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-maDC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

BIRC2 TIAM1 LAD1

4.79e-041853737e3d9f5050e71e91021245c11101e994ae41d22b
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

F8 PCLO AFAP1L1

4.79e-04185373f9f48251bc33eb6bf2cff580d1a3207d21450aa0
ToppCellCOVID-19-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

PLCB1 F8 AFAP1L1

4.79e-0418537336ce23893915f5c380cca39b2c33a516edf31c3a
ToppCellControl-Lymphoid-ILC_A|Lymphoid / Disease state, Lineage and Cell class

SOX4 PLCB1 TIAM1

4.79e-04185373520795866d44def5be3910ce8e728045c716a24d
ToppCellCOVID-19-Neuronal_cells-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

PLCB1 F8 AFAP1L1

4.79e-041853734a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCellILEUM-inflamed-(7)_Lymphatics|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

F8 PCLO AFAP1L1

4.79e-04185373d711dd2e91cfee723dae1ccb2b910b8cf3becc3b
ToppCell5'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLCB1 RNASE1 AFAP1L1

4.87e-04186373e9d12f2fcd346fc8d00f7178324ea5997628df8a
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCR4 RNASE1 AFAP1L1

4.95e-041873730ef82111b9049cc7ee78d64d240e1f10ab14d6b6
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

PLCB1 SHROOM1 F8

4.95e-0418737340ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellE12.5-Epithelial|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NEXMIF LAD1 AFAP1L1

4.95e-0418737329ea5e14dac3321df76f6aa4f053068b49c4a4bf
ToppCellControl-Myeloid-DC_Mature|Control / Disease state, Lineage and Cell class

BIRC2 TIAM1 LAD1

4.95e-04187373049780ca2a3e6adcd89dc2cf3095b5ad068b244a
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLCB1 RNASE1 AFAP1L1

4.95e-0418737325efb82afe863a853ecdd781ad89026c993aaa67
ToppCellControl-Myeloid-DC_Mature|World / Disease state, Lineage and Cell class

BIRC2 TIAM1 LAD1

4.95e-0418737351bfc450e78284796b02317e91830357850b5437
ToppCellwk_20-22-Endothelial-Lymph_endothelial-SCG3+_lymphatic_endothelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

F8 PCLO AFAP1L1

4.95e-0418737355aad84b992412e487a32f4970620189a7380ba6
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RNASE1 IQCJ-SCHIP1 AFAP1L1

4.95e-0418737329b2e2be26a9d72b154760e47acf61cfe2f45fa7
ToppCell5'-Adult-Distal_Rectal-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

F8 PCDHGA2 AFAP1L1

5.02e-04188373524a12f433c7b6f33fad36c0716afa06cd3235e9
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

SHROOM1 PCLO LAD1

5.02e-04188373ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

PLCB1 F8 AFAP1L1

5.02e-04188373117dc80fa940e6aa1b0187a43fdde33f3fcb578f
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC-arterial_capillary|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLCB1 RNASE1 F8

5.02e-04188373a11b12f1857953bcdbfb5f25e127f2350c39567d
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX4 KAT6B PCDHGA2

5.02e-04188373e239bcdbd210a398a5850cb6fbf171d402f45a4f
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLCB1 RNASE1 AFAP1L1

5.02e-041883730026c9479b30fb39daa91cfa220a88f9c9e65fe7
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic_-_developing-thymocyte|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SERTAD2 SOX4 CCR4

5.02e-04188373bcfc426b60d8e5a23a2360bfb68b32868fec9fbf
ToppCelldroplet-Tongue-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NR4A2 SOX4 SRRM2

5.02e-04188373d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCell5'-Adult-Distal_Rectal-Endothelial-lymphatic_endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

F8 PCDHGA2 AFAP1L1

5.02e-04188373d2610b81b3c7f22977b5e2137b1f61410fc4ef16
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX4 PLCB1 UBAP2

5.10e-041893738e6b6025f5554672e26a5d19fe365acb4333789c
ToppCellIPF-Lymphoid-T_Regulatory|Lymphoid / Disease state, Lineage and Cell class

TET2 CCR4 TIAM1

5.10e-041893737a260485c2a7c743c14d048e5e480ae0a9b8e32c
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature-endo_bronchial_(8)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RNASE1 IQCJ-SCHIP1 AFAP1L1

5.10e-041893734bc3826e0515b3cf2e2ef72a7b2cf9c32ade1812
ToppCellCOVID-19-Heart-EC_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

PLCB1 F8 AFAP1L1

5.10e-04189373fe49852ba15f948b384d6b4c258927c70b741357
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE1 SELENON F8

5.18e-04190373141266bf411ea675fbf889b20c1b08673c45ff95
ToppCellCOVID-19-Endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

PLCB1 F8 AFAP1L1

5.18e-041903739fbd92cd6d4683b2490504d29c43cf42020433d4
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

POLI GCDH CENPL

5.18e-041903733f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|kidney / Disease (COVID-19 only), tissue and cell type

PLCB1 SHROOM1 F8

5.18e-041903731519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCellE15.5-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NEXMIF LAD1 AFAP1L1

5.26e-041913736f5d91a9583bbb30dfaa30dd9c7772995a9196be
Diseaseurate measurement, bone density

SERTAD2 PLCB1 NAT1 KAT6B SELENON ERBIN

1.11e-04619376EFO_0003923, EFO_0004531
Diseasecervical squamous cell carcinoma (is_marker_for)

BIRC2 CCR4

3.48e-0422372DOID:3744 (is_marker_for)
DiseaseSezary Syndrome

TET2 CCR4

5.26e-0427372C0036920
DiseaseHematopoetic Myelodysplasia

PLCB1 TET2

6.08e-0429372C2713368
Diseasemyelodysplastic syndrome (is_implicated_in)

PLCB1 TET2

6.51e-0430372DOID:0050908 (is_implicated_in)
Diseaseage at menarche

NR4A2 PLCB1 TET2 GCDH MADD

8.32e-04594375EFO_0004703
DiseaseAutoimmune Diseases

PTPN22 F8

1.28e-0342372C0004364
Diseaseacute myeloid leukemia (is_marker_for)

PLCB1 TET2

1.73e-0349372DOID:9119 (is_marker_for)
Diseaseresponse to efavirenz, virologic response measurement

IQCJ-SCHIP1 TIAM1

2.42e-0358372EFO_0006904, EFO_0006906

Protein segments in the cluster

PeptideGeneStartEntry
DFESMNTYLQTSPSS

NAT1

201

P18440
TMSVSDFNYSRTSPS

ERBIN

1156

Q96RT1
DTPSSSYTQSTMDHD

CCR4

341

P51679
NDNAPEFYMTSATSS

PCDHGA2

341

Q9Y5H1
YSTSYPDTMENSTSS

PTPN22

721

Q9Y2R2
TTENYENPSSYDSTM

KAT6B

1676

Q8WYB5
EADMSSPTQRTYSSS

LAD1

351

O00515
SGSDSMDYDDSSSSY

MADD

621

Q8WXG6
SSSSYSSLGDFVSEM

MADD

631

Q8WXG6
EMPDSDENGSYSTSS

EDRF1

541

Q3B7T1
MASSPISSISADSFY

PCLO

4021

Q9Y6V0
DLEPDYSSYMTSSTS

PCLO

4211

Q9Y6V0
ATYSFSSSMSASSAG

MUC3A

531

Q02505
ASSYFTNMFATWSPS

F8

2211

P00451
MESSSSSNSYFSVGP

GNPAT

1

O15228
MDSYSAPESTPSASS

CENPL

1

Q8N0S6
SDPSSMETRAHYNSS

GCDH

186

Q92947
TSSYNASMADSPGEE

NSMAF

586

Q92636
EPGTSGFNSSSSSYM

POLI

601

Q9UNA4
SLPSFSTFMDNYSTG

NR4A2

56

P43354
SSNFESMSLGSFSSS

SOX4

411

Q06945
MSPEQSRFQSDSSSY

SRRM2

1131

Q9UQ35
FSFDSMAPLSVSSSN

NEXMIF

991

Q5QGS0
TSDTSYSDMAAGSDP

SETD5

11

Q9C0A6
SMRADSAYSSFSAAS

SHROOM1

26

Q2M3G4
VSMNTFSDSSTPDYR

IQCJ-SCHIP1

86

B3KU38
MDSDSSPSSSSTYCN

RNASE1

41

P07998
SSRTNPYSYAMSTEE

BIRC2

171

Q13490
KSSYNDSDAMSSSYE

AFAP1L1

176

Q8TED9
MGTFNPADYSDSTST

UBAP2

191

Q5T6F2
SYTSNGPTFMETASF

TIAM1

151

Q13009
TRSFFSNYTAPSATM

RNF34

176

Q969K3
IDTSMYDFDPCTSSS

SERTAD2

251

Q14140
FSSTFEDPSTATYMQ

SELENON

561

Q9NZV5
ASNTYSDSSSMFEPS

PLCB1

486

Q9NQ66
MSSDASASTDSNTYY

UBR4

556

Q5T4S7
STSPMNFYSTSSQAA

TET2

1591

Q6N021
MDTSSLASAYADFSS

PHOX2B

21

Q99453
QTDFSSSPSTNEMFT

USP32

1011

Q8NFA0