Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	cilium	TMEM67 EFCAB6 INPP5E GRK7 PKD1L1 GAS8 TOGARAM1 WBP2NL PDZD7 SHANK3 CEP170 NEDD9 SPTBN5 CATSPER1 SHANK2 PROM2 CIBAR1 IQCB1 ZMYND12 PHLPP2	9.26e-06	898	153	20	GO:0005929
GeneOntologyCellularComponent	ciliary membrane	TMEM67 PKD1L1 SHANK3 SHANK2 PROM2 PHLPP2	8.43e-05	98	153	6	GO:0060170
Domain	ARM-type_fold	PPP4R1 ATR NBEAL1 DOCK9 HSF2BP TOGARAM1 RICTOR TSC2 HUWE1 PELP1 XPO6 NOM1 IQCB1 NOC4L UNC79	1.09e-07	339	151	15	IPR016024
Domain	ARM-like	PPP4R1 ATR HSF2BP TOGARAM1 RICTOR TSC2 HUWE1 PELP1 XPO6 AP5Z1 IQCB1 NOC4L	2.06e-06	270	151	12	IPR011989
Domain	PDZ	PDZD7 SIPA1 SHANK3 PTPN13 MAST4 SHANK2 ARHGAP21	1.50e-04	141	151	7	PF00595
Domain	BAT2_N	PRRC2A PRRC2B	1.94e-04	3	151	2	PF07001
Domain	Calcipressin	RCAN3 RCAN2	1.94e-04	3	151	2	IPR006931
Domain	BAT2_N	PRRC2A PRRC2B	1.94e-04	3	151	2	IPR009738
Domain	Calcipressin	RCAN3 RCAN2	1.94e-04	3	151	2	PF04847
Domain	PRRC2	PRRC2A PRRC2B	1.94e-04	3	151	2	IPR033184
Domain	PDZ	PDZD7 SIPA1 SHANK3 PTPN13 MAST4 SHANK2 ARHGAP21	2.03e-04	148	151	7	SM00228
Domain	-	PDZD7 SIPA1 SHANK3 PTPN13 MAST4 SHANK2 ARHGAP21	2.20e-04	150	151	7	2.30.42.10
Domain	PDZ	PDZD7 SIPA1 SHANK3 PTPN13 MAST4 SHANK2 ARHGAP21	2.29e-04	151	151	7	PS50106
Domain	PDZ	PDZD7 SIPA1 SHANK3 PTPN13 MAST4 SHANK2 ARHGAP21	2.39e-04	152	151	7	IPR001478
Domain	fn3	NPHS1 OBSCN IGDCC4 PTPRG RIMBP2 CNTN2 SORL1	3.52e-04	162	151	7	PF00041
Domain	SH3	ARHGAP32 OBSCN SORBS1 SHANK3 NEDD9 SHANK2 RIMBP2 MYO15A	3.79e-04	216	151	8	SM00326
Domain	SH3	ARHGAP32 OBSCN SORBS1 SHANK3 NEDD9 SHANK2 RIMBP2 MYO15A	3.79e-04	216	151	8	PS50002
Domain	SH3_domain	ARHGAP32 OBSCN SORBS1 SHANK3 NEDD9 SHANK2 RIMBP2 MYO15A	4.29e-04	220	151	8	IPR001452
Domain	-	PPP4R1 ATR HSF2BP TOGARAM1 RICTOR TSC2 XPO6 AP5Z1	4.55e-04	222	151	8	1.25.10.10
Domain	SH3_2	SORBS1 SHANK3 SHANK2 RIMBP2 MYO15A	6.65e-04	86	151	5	PF07653
Domain	SH3_2	SORBS1 SHANK3 SHANK2 RIMBP2 MYO15A	6.65e-04	86	151	5	IPR011511
Domain	PH_dom-like	KIF1A NBEAL1 DOCK9 OBSCN WBP2NL RABGAP1 SPTBN5 PTPN13 OSBPL5 ARHGAP21 PHLPP2	7.05e-04	426	151	11	IPR011993
Domain	FN3	NPHS1 OBSCN IGDCC4 PTPRG RIMBP2 CNTN2 SORL1	7.77e-04	185	151	7	SM00060
Domain	BRK	CHD9 CHD8	9.53e-04	6	151	2	SM00592
Domain	BRK_domain	CHD9 CHD8	9.53e-04	6	151	2	IPR006576
Domain	Kinesin-like	KIF1A RABGAP1	9.53e-04	6	151	2	IPR022164
Domain	DUF3694	KIF1A RABGAP1	9.53e-04	6	151	2	PF12473
Domain	BRK	CHD9 CHD8	9.53e-04	6	151	2	PF07533
Domain	FN3	NPHS1 OBSCN IGDCC4 PTPRG RIMBP2 CNTN2 SORL1	1.19e-03	199	151	7	PS50853
Domain	Kinase-like_dom	TSSK6 ATR GRK7 KSR2 OBSCN CHD9 MST1R PTPN13 MAST4 DYRK1B PRKCQ WNK2	1.53e-03	542	151	12	IPR011009
Domain	FN3_dom	NPHS1 OBSCN IGDCC4 PTPRG RIMBP2 CNTN2 SORL1	1.58e-03	209	151	7	IPR003961
Domain	SNF2_N	EP400 CHD9 CHD8	2.16e-03	32	151	3	IPR000330
Domain	SNF2_N	EP400 CHD9 CHD8	2.16e-03	32	151	3	PF00176
Domain	SPEC	AKAP6 EVPL SPTBN5	2.16e-03	32	151	3	SM00150
Domain	Spectrin/alpha-actinin	AKAP6 EVPL SPTBN5	2.16e-03	32	151	3	IPR018159
Domain	IQ	MYO9A OBSCN IQCB1 MYO15A	2.62e-03	71	151	4	PF00612
Domain	Rap_GAP	TSC2 SIPA1	2.80e-03	10	151	2	PF02145
Domain	PTPc	PTPN13 PTPRG PTPRN2	3.04e-03	36	151	3	SM00194
Domain	Rap_GAP_dom	TSC2 SIPA1	3.40e-03	11	151	2	IPR000331
Domain	RAPGAP	TSC2 SIPA1	3.40e-03	11	151	2	PS50085
Domain	SH3_9	ARHGAP32 SORBS1 NEDD9 RIMBP2	3.68e-03	78	151	4	PF14604
Domain	TYR_PHOSPHATASE_PTP	PTPN13 PTPRG PTPRN2	3.83e-03	39	151	3	PS50055
Domain	-	ERCC5 MARF1	4.06e-03	12	151	2	3.40.50.1010
Domain	IQ	MYO9A OBSCN IQCB1 MYO15A	4.22e-03	81	151	4	SM00015
Domain	PTPase_domain	PTPN13 PTPRG PTPRN2	4.41e-03	41	151	3	IPR000242
Domain	Y_phosphatase	PTPN13 PTPRG PTPRN2	4.41e-03	41	151	3	PF00102
Domain	-	KIF1A DOCK9 OBSCN RABGAP1 SPTBN5 PTPN13 OSBPL5 ARHGAP21 PHLPP2	4.59e-03	391	151	9	2.30.29.30
Domain	PIN_domain-like	ERCC5 MARF1	5.54e-03	14	151	2	IPR029060
Domain	IQ_motif_EF-hand-BS	MYO9A OBSCN IQCB1 MYO15A	6.13e-03	90	151	4	IPR000048
Domain	IQ	MYO9A OBSCN IQCB1 MYO15A	6.87e-03	93	151	4	PS50096
Domain	PH_DOMAIN	KIF1A DOCK9 OBSCN SPTBN5 OSBPL5 ARHGAP21 PHLPP2	7.67e-03	279	151	7	PS50003
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	AKAP6 CHD9 HUWE1 MAST4 PER2 PTPRN2 XPO6 ZFYVE26 RIMBP2 SRRM2 DYNC1H1	1.40e-12	104	154	11	9205841
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	EP400 NSD2 INPP5E MTG2 DOCK9 KSR2 OBSCN TBC1D25 CHD8 TSC2 HUWE1 GGT7 MST1R SHANK2 PER2 ZNF341 PROM2 XPO6 OSBPL5 SAC3D1 ZFYVE26 ARHGAP21 DYNC1H1 WNK2 PRRC2B	2.20e-11	1105	154	25	35748872
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ARHGAP32 ANK2 KSR2 CHD8 TSC2 SORBS1 HUWE1 SIPA1 SHANK3 CEP170 SHANK2 PELP1 PTPRN2 ANAPC1 SVIL RIMBP2 MGA UNC79 PRRC2A ARHGAP21 DYNC1H1 WNK2 PRRC2B	5.24e-11	963	154	23	28671696
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ARHGAP32 CARMIL2 MYO9A INPP5E GRK7 RICTOR TSC2 SORBS1 CEP170 PTPN13 MAST4 SVIL IQCB1 DYRK1B MPHOSPH9 SRRM2 PALLD ARHGAP21 DOP1B	1.02e-08	861	154	19	36931259
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PPP4R1 ARHGAP32 RPN2 NSD2 RICTOR PSMD11 HUWE1 RCAN3 PTPN13 PTPRG PTPRN2 SVIL NOC4L MPHOSPH9 SRRM2 PRRC2A PRRC2B PHLPP2	1.03e-06	1049	154	18	27880917
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PPP4R1 THNSL1 ATR RPN2 RICTOR CHD8 NOM1 NEMF MARF1 HPS5 PALLD ARHGAP21 PRRC2B SORL1	1.32e-06	650	154	14	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	KIF1A RPN2 NSD2 CHD8 PRPF6 HUWE1 CEP170 PELP1 ANAPC1 NOC4L SRRM2 PRRC2A DYNC1H1 PRRC2B	1.39e-06	653	154	14	22586326
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	EP400 DOCK9 SORBS1 IGDCC4 PER2 RIMBP2 SRRM2 ARHGAP21 DYNC1H1 PRRC2B DOP1B	2.22e-06	407	154	11	12693553
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	NSD2 INPP5E CHD8 HUWE1 CENPP AP5Z1 SVIL PRRC2A DYNC1H1 PRRC2B	2.50e-06	332	154	10	37433992
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	MYO9A RPN2 POLR1C HUWE1 GGT7 CEP170 NOM1 NEMF NOC4L SRRM2 PRRC2A	1.19e-05	486	154	11	30940648
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	ANK2 SORBS1 CEP170 SVIL ARHGAP21	1.23e-05	67	154	5	29254152
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	AKAP6 ANK2 DOCK9 OBSCN SORBS1 OSGEP CEP170 NEDD9 MGA PALLD ARHGAP21	1.46e-05	497	154	11	23414517
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	AKAP6 GABRD PPP4R1 ANK2 KIF1A POLR1C CHD9 TSC2 SORBS1 HUWE1 CREBZF PTPN13 COG1 NEMF PRRC2A ARHGAP21 DYNC1H1 DOP1B	1.67e-05	1285	154	18	35914814
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	EP400 CHD8 PRPF6 HUWE1 PELP1 ANAPC1 SRRM2 PALLD DYNC1H1	1.86e-05	332	154	9	32786267
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	POP4 NSD2 HUWE1 CEP170 PELP1 SVIL NEMF NOC4L PRRC2A	1.86e-05	332	154	9	25693804
Pubmed	Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice.	SHANK3 SHANK2	1.95e-05	2	154	2	33126897
Pubmed	PELP1 promotes the expression of RUNX2 via the ERK pathway during the osteogenic differentiation of human periodontal ligament stem cells.	RUNX2 PELP1	1.95e-05	2	154	2	33607589
Pubmed	Microglial ASD-related genes are involved in oligodendrocyte differentiation.	CHD8 TSC2	1.95e-05	2	154	2	34497307
Pubmed	Impaired mitochondrial dynamics underlie axonal defects in hereditary spastic paraplegias.	AP5Z1 ZFYVE26	1.95e-05	2	154	2	29726929
Pubmed	[Expression of RUNX2/LAPTM5 in MC3T3-E1 osteoblastic cells with induced mineralization].	RUNX2 LAPTM5	1.95e-05	2	154	2	34658355
Pubmed	Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2.	SHANK3 SHANK2	1.95e-05	2	154	2	22699619
Pubmed	Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model.	SHANK3 SHANK2	1.95e-05	2	154	2	31052177
Pubmed	mTORC2 regulates auditory hair cell structure and function.	RICTOR MYO15A	1.95e-05	2	154	2	37694145
Pubmed	Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus.	SHANK3 SHANK2	1.95e-05	2	154	2	27199660
Pubmed	The Tumor Suppressor NKX3.1 Is Targeted for Degradation by DYRK1B Kinase.	DYRK1B NKX3-1	1.95e-05	2	154	2	25777618
Pubmed	Murine tyrosine hydroxylase maps to the distal end of chromosome 7 within a region conserved in mouse and man.	ITGAL TH	1.95e-05	2	154	2	2889817
Pubmed	Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development.	SHANK3 SHANK2	1.95e-05	2	154	2	10506216
Pubmed	Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice.	RICTOR DYRK1B	1.95e-05	2	154	2	34855620
Pubmed	Expression profiles of the autism-related SHANK proteins in the human brain.	SHANK3 SHANK2	1.95e-05	2	154	2	37953224
Pubmed	Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders.	SHANK3 SHANK2	1.95e-05	2	154	2	36100669
Pubmed	Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses.	ATR SLC34A1	1.95e-05	2	154	2	31589169
Pubmed	Proline-rich synapse-associated protein-1 and 2 (ProSAP1/Shank2 and ProSAP2/Shank3)-scaffolding proteins are also present in postsynaptic specializations of the peripheral nervous system.	SHANK3 SHANK2	1.95e-05	2	154	2	20800661
Pubmed	SHANK3 in vagal sensory neurons regulates body temperature, systemic inflammation, and sepsis.	SHANK3 SHANK2	1.95e-05	2	154	2	36845137
Pubmed	Advancing the understanding of autism disease mechanisms through genetics.	TSC2 SHANK3 SHANK2	2.36e-05	13	154	3	27050589
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	KIF1A DOCK9 SORBS1 SHANK2 GLRA2 ARHGAP21	2.38e-05	128	154	6	30995482
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	DSC1 POLR1C PRPF6 ANAPC1 MARF1 MGA PALLD DYNC1H1	3.08e-05	272	154	8	31010829
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	POP4 EVPL SIPA1 CEP170 GSPT2 SVIL SRRM2 PRRC2A DYNC1H1	3.50e-05	360	154	9	33111431
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	EP400 CHD8 HUWE1 CEP170 PTPN13 ANAPC1 MGA PRRC2A PALLD DYNC1H1 PRRC2B	3.62e-05	549	154	11	38280479
Pubmed	Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2.	ALKBH5 MYO15A	5.83e-05	3	154	2	10552926
Pubmed	SMILE inhibits BMP-2-induced expression of osteocalcin by suppressing the activity of the RUNX2 transcription factor in MC3T3E1 cells.	RUNX2 CREBZF	5.83e-05	3	154	2	24389415
Pubmed	Translational neurobiology in Shank mutant mice--model systems for neuropsychiatric disorders.	SHANK3 SHANK2	5.83e-05	3	154	2	25917711
Pubmed	mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation.	RICTOR TSC2	5.83e-05	3	154	2	25893604
Pubmed	TMEM67 is required for the gating function of the transition zone that controls entry of membrane-associated proteins ARL13B and INPP5E into primary cilia.	TMEM67 INPP5E	5.83e-05	3	154	2	36334440
Pubmed	Heterogeneity of Cell Surface Glutamate and GABA Receptor Expression in Shank and CNTN4 Autism Mouse Models.	SHANK3 SHANK2	5.83e-05	3	154	2	29970989
Pubmed	Obscurin targets ankyrin-B and protein phosphatase 2A to the cardiac M-line.	ANK2 OBSCN	5.83e-05	3	154	2	18782775
Pubmed	S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis.	SHANK3 SHANK2	5.83e-05	3	154	2	34741005
Pubmed	The murine DSCR1-like (Down syndrome candidate region 1) gene family: conserved synteny with the human orthologous genes.	RCAN3 RCAN2	5.83e-05	3	154	2	11080588
Pubmed	The Shank family of scaffold proteins.	SHANK3 SHANK2	5.83e-05	3	154	2	10806096
Pubmed	LAPTM5 is transactivated by RUNX2 and involved in RANKL trafficking in osteoblastic cells.	RUNX2 LAPTM5	5.83e-05	3	154	2	31545469
Pubmed	Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles.	ANK2 OBSCN	5.83e-05	3	154	2	12527750
Pubmed	The transcription factor Runx2 is under circadian control in the suprachiasmatic nucleus and functions in the control of rhythmic behavior.	RUNX2 PER2	5.83e-05	3	154	2	23372705
Pubmed	A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2).	RCAN3 RCAN2	5.83e-05	3	154	2	10756093
Pubmed	Modeling autism by SHANK gene mutations in mice.	SHANK3 SHANK2	5.83e-05	3	154	2	23583105
Pubmed	Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.	RCAN3 RCAN2	5.83e-05	3	154	2	17595344
Pubmed	A systematic variant annotation approach for ranking genes associated with autism spectrum disorders.	CHD8 SHANK3	5.83e-05	3	154	2	27790361
Pubmed	Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.	ATR CDT1	5.83e-05	3	154	2	23029527
Pubmed	Dynamic Change of Shanks Gene mRNA Expression and DNA Methylation in Epileptic Rat Model and Human Patients.	SHANK3 SHANK2	5.83e-05	3	154	2	32564287
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	AKAP6 PPP4R1 ANK2 RABGAP1 CEP170 DYNC1H1	6.00e-05	151	154	6	17043677
Pubmed	Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.	TMEM67 INPP5E IQCB1	6.62e-05	18	154	3	21068128
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	PPP4R1 EP400 MYO9A SORBS1 RABGAP1 HUWE1 ALKBH5 ANAPC1 IQCB1 PRRC2B SORL1	6.69e-05	588	154	11	38580884
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	AKAP6 DOCK9 TOGARAM1 CHD8 XPO6 HPS5 DOP1B	6.86e-05	225	154	7	12168954
Pubmed	Functional proteomics mapping of a human signaling pathway.	PSMD11 HUWE1 CREBZF LAPTM5 NEDD9 MAST4 PELP1 ZNF341 NOM1 MGA DYNC1H1	7.00e-05	591	154	11	15231748
Pubmed	Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH.	CARS1 TH OSBPL5	7.83e-05	19	154	3	12473685
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	ARHGAP32 ANK2 MYO9A RPN2 RICTOR CEP170 PTPN13 MPHOSPH9 PRRC2A PALLD ARHGAP21 DYNC1H1	7.97e-05	708	154	12	39231216
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	MTG2 RICTOR TSC2 PSMD11 HUWE1 CEP170 COG1 ANAPC1 NOM1 DYRK1B ARHGAP21	8.74e-05	606	154	11	36538041
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	KIF1A MYO9A NSD2 KSR2 OBSCN CHD9 RABGAP1 HUWE1 CEP170 PTPN13 SHANK2 PTPRG PTPRN2 PROM2 NEMF OSBPL5 HPS5 WNK2	1.12e-04	1489	154	18	28611215
Pubmed	The TSC-mTOR signaling pathway regulates the innate inflammatory response.	TSC2 PRKCQ	1.16e-04	4	154	2	18848473
Pubmed	SHANK3 gene mutations associated with autism facilitate ligand binding to the Shank3 ankyrin repeat region.	SHANK3 SHANK2	1.16e-04	4	154	2	23897824
Pubmed	A novel anesthesia regime enables neurofunctional studies and imaging genetics across mouse strains.	TSC2 SHANK3	1.16e-04	4	154	2	27080031
Pubmed	Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models.	TSC2 SHANK3	1.16e-04	4	154	2	30237867
Pubmed	Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population.	SHANK3 SHANK2	1.16e-04	4	154	2	23468870
Pubmed	The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42.	SHANK3 SHANK2	1.16e-04	4	154	2	12626503
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	KIF1A RPN2 EVPL PSMD11 HUWE1 OSGEP GGT7 ADSL PTPRN2 CIBAR1 SRRM2 PRRC2A PRRC2B SORL1	1.17e-04	974	154	14	28675297
Pubmed	Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting.	CARS1 TH OSBPL5	1.23e-04	22	154	3	11063728
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	AKAP6 EP400 NSD2 INPP5E CHD8 MAST4 AP5Z1 OSBPL5 HPS5 WNK2	1.33e-04	529	154	10	14621295
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	POP4 MYO9A RPN2 CHD9 LAPTM5 GARIN3 RNF125 ZNF341 NOM1 CIBAR1 RIMBP2 MYO15A RUNDC1 VWA5B1 PRRC2B DOP1B	1.34e-04	1242	154	16	30973865
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	ARHGAP32 EP400 PHF23 NEDD9 GSPT2 MGA RUNDC1 DYNC1H1 WNK2	1.36e-04	430	154	9	35044719
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	RPN2 INPP5E POLR1C CHD9 PRPF6 PSMD11 HUWE1 RUNX2 GSPT2 ADSL SVIL NEMF SRRM2 MGA PRRC2A DYNC1H1	1.40e-04	1247	154	16	27684187
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	NSD2 CHD9 CHD8 PTPN13 PELP1 ANAPC1 NOM1 SRRM2 MGA DYNC1H1	1.41e-04	533	154	10	30554943
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	THNSL1 DSC1 RPN2 POLR1C PRPF6 PSMD11 HUWE1 ADSL RIMBP2 MPHOSPH9 SRRM2 PRRC2A PRRC2B PHLPP2	1.61e-04	1005	154	14	19615732
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	ANK2 DOCK9 SORBS1 SHANK2 DYRK1B RIMBP2 SRRM2 PRRC2A	1.67e-04	347	154	8	17114649
Pubmed	USP7 Regulates Cytokinesis through FBXO38 and KIF20B.	EP400 CHD8 NOC4L CDT1 PRRC2B	1.72e-04	116	154	5	30804394
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ERCC5 ATR EP400 RICTOR HUWE1 ANAPC1 XPO6 SVIL SAC3D1 CDT1 SRRM2 PRRC2A	1.83e-04	774	154	12	15302935
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	EFCAB6 EP400 LGR4 RICTOR HUWE1 PTPN13 NOM1 MPHOSPH9 MGA ARHGAP21 DYNC1H1 PRRC2B	1.89e-04	777	154	12	35844135
Pubmed	RCAN 1 and 3 proteins regulate thymic positive selection.	RCAN3 RCAN2	1.93e-04	5	154	2	25783055
Pubmed	A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia.	AP5Z1 ZFYVE26	1.93e-04	5	154	2	20613862
Pubmed	Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor.	SHANK3 SHANK2	1.93e-04	5	154	2	16606358
Pubmed	Chromodomain helicase binding protein 8 (Chd8) is a novel A-kinase anchoring protein expressed during rat cardiac development.	AKAP6 CHD8	1.93e-04	5	154	2	23071553
Pubmed	Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).	CARS1 OSBPL5	1.93e-04	5	154	2	12466268
Pubmed	The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42.	SHANK3 SHANK2	1.93e-04	5	154	2	12504591
Pubmed	TSC1 controls macrophage polarization to prevent inflammatory disease.	RICTOR TSC2	1.93e-04	5	154	2	25175012
Pubmed	Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway.	RCAN3 RCAN2	1.93e-04	5	154	2	19819266
Pubmed	NSD2 is a conserved driver of metastatic prostate cancer progression.	NSD2 NKX3-1	1.93e-04	5	154	2	30518758
Pubmed	C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.	PRPF6 PSMD11 HUWE1 SRRM2 PRRC2A	1.94e-04	119	154	5	35776542
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	PPP4R1 RPN2 POLR1C GAS8 TSC2 PRPF6 SORBS1 PSMD11 OSGEP MYCBPAP CDAN1 XPO6 NOM1 SRRM2 UNC79 DYNC1H1	1.95e-04	1284	154	16	17353931
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	AKAP6 POP4 EFCAB6 EVPL RICTOR PRPF6 PSMD11 RCAN3 CEP170 NEDD9 MST1R ADSL SLC34A1 SAC3D1 RCAN2 DOP1B	2.11e-04	1293	154	16	15342556
Pubmed	Human transcription factor protein interaction networks.	ARHGAP32 EP400 PHF23 RPN2 CHD8 PSMD11 TLX2 LHX2 SVIL MARF1 NOC4L SRRM2 MGA PRRC2A DYNC1H1 PRRC2B SORL1	2.11e-04	1429	154	17	35140242
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	ARHGAP32 CARMIL2 ANK2 MYO9A SORBS1 SIPA1 SHANK3 CEP170 SHANK2 SVIL RIMBP2 PRRC2A ARHGAP21 DYNC1H1 CNTN2 WNK2 PRRC2B	2.15e-04	1431	154	17	37142655
Pubmed	A comprehensive resource of interacting protein regions for refining human transcription factor networks.	ANK2 KIF1A PELP1 NOM1 PRRC2A ARHGAP21	2.17e-04	191	154	6	20195357
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	EP400 GAS8 OBSCN PSMD11 SHANK3 PTPN13 PROM2 IQCB1 SAC3D1 MYO15A	2.22e-04	564	154	10	21565611
Interaction	YWHAH interactions	ARHGAP32 CARMIL2 MYO9A INPP5E DOCK9 KSR2 RICTOR TBC1D25 TSC2 PRPF6 SORBS1 HUWE1 SIPA1 TLX2 CEP170 MST1R PTPN13 MAST4 SVIL IQCB1 OSBPL5 MPHOSPH9 SRRM2 PALLD ARHGAP21 WNK2 SMTNL2 DOP1B	9.95e-09	1102	150	28	int:YWHAH
Interaction	YWHAZ interactions	ARHGAP32 CARMIL2 DSC1 MYO9A INPP5E DOCK9 KSR2 LGR4 RICTOR TSC2 SORBS1 HUWE1 SIPA1 SHANK3 CEP170 MST1R TH PTPN13 ADRA2B MAST4 ADSL PER2 SVIL MPHOSPH9 RUNDC1 PRRC2A ARHGAP21 DYNC1H1 WNK2 SMTNL2	3.33e-08	1319	150	30	int:YWHAZ
Interaction	YWHAB interactions	ARHGAP32 CARMIL2 MYO9A INPP5E DOCK9 KSR2 RICTOR TSC2 PRPF6 SORBS1 SIPA1 SHANK3 CEP170 MST1R TH PTPN13 MAST4 SVIL IQCB1 MPHOSPH9 SRRM2 ARHGAP21 DYNC1H1 SMTNL2	4.76e-07	1014	150	24	int:YWHAB
Interaction	TOP3B interactions	EP400 NSD2 INPP5E MTG2 DOCK9 KSR2 OBSCN TBC1D25 CHD8 TSC2 HUWE1 GGT7 MST1R SHANK2 PER2 PELP1 ZNF341 PROM2 XPO6 SVIL OSBPL5 SAC3D1 ZFYVE26 PRRC2A ARHGAP21 DYNC1H1 WNK2 PRRC2B	3.58e-06	1470	150	28	int:TOP3B
Interaction	YWHAE interactions	ARHGAP32 CARMIL2 MYO9A INPP5E DOCK9 KSR2 RICTOR TSC2 SORBS1 HUWE1 SHANK3 CEP170 MST1R PTPN13 MAST4 PER2 SVIL MPHOSPH9 SRRM2 MGA PRRC2A ARHGAP21 DYNC1H1 WNK2 SMTNL2	6.07e-06	1256	150	25	int:YWHAE
Interaction	PKD2 interactions	RPN2 HSF2BP TMC4 CEP170 PTPRG GLRA2 OR6T1	6.55e-06	94	150	7	int:PKD2
Interaction	YWHAQ interactions	ARHGAP32 CARMIL2 MYO9A KSR2 RICTOR TSC2 SORBS1 PSMD11 SIPA1 SHANK3 MEFV CEP170 MST1R TH PTPN13 MAST4 SVIL PRKCQ MPHOSPH9 UNC79 ARHGAP21 DYNC1H1 SMTNL2	8.84e-06	1118	150	23	int:YWHAQ
Interaction	YWHAG interactions	ARHGAP32 CARMIL2 MYO9A INPP5E DOCK9 KSR2 LGR4 RICTOR TSC2 SORBS1 HUWE1 SIPA1 SHANK3 CEP170 MST1R PTPN13 MAST4 SVIL PRKCQ MPHOSPH9 SRRM2 ARHGAP21 DYNC1H1 SMTNL2	1.69e-05	1248	150	24	int:YWHAG
Interaction	TNIK interactions	ARHGAP32 ANK2 CHD8 HUWE1 SHANK3 CEP170 SHANK2 RIMBP2 MGA ARHGAP21 DYNC1H1 PRRC2B	2.91e-05	381	150	12	int:TNIK
Interaction	NPTN interactions	ATR NBEAL1 TSC2 HUWE1 COG1 XPO6 AP5Z1 NOC4L ZFYVE26 DOP1B	4.55e-05	278	150	10	int:NPTN
Interaction	GYPA interactions	ATR TSC2 RABGAP1 LAPTM5 BCL2L12 XPO6 IQCB1 NEMF	4.88e-05	174	150	8	int:GYPA
Interaction	MYCBP2 interactions	ANK2 NSD2 LGR4 SORBS1 HUWE1 SIPA1 PELP1 SVIL UNC79 ARHGAP21 DYNC1H1	7.30e-05	355	150	11	int:MYCBP2
GeneFamily	PDZ domain containing	PDZD7 SIPA1 SHANK3 PTPN13 MAST4 SHANK2 ARHGAP21	1.76e-05	152	97	7	1220
GeneFamily	Fibronectin type III domain containing	NPHS1 OBSCN IGDCC4 PTPRG CNTN2 SORL1	2.22e-04	160	97	6	555
Coexpression	GSE27786_NKTCELL_VS_MONO_MAC_UP	CHD8 SORBS1 HUWE1 LAPTM5 ANAPC1 XPO6 NEMF OSBPL5 MGA	2.68e-06	200	152	9	M4870
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	AKAP6 ANK2 OBSCN SORBS1 MAST4 SVIL PALLD WNK2 RCAN2	2.11e-08	189	154	9	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	AKAP6 ANK2 OBSCN SORBS1 MAST4 SVIL PALLD WNK2 RCAN2	2.21e-08	190	154	9	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	AKAP6 ANK2 OBSCN SORBS1 MAST4 SVIL PALLD WNK2 RCAN2	2.31e-08	191	154	9	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	AKAP6 ANK2 OBSCN SORBS1 MAST4 SVIL PALLD WNK2 RCAN2	2.31e-08	191	154	9	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	AKAP6 ANK2 OBSCN SORBS1 MAST4 SVIL PALLD WNK2 RCAN2	2.64e-08	194	154	9	c3535f7cc0076653c72db582047cff053c322397
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	AKAP6 ANK2 OBSCN SORBS1 MAST4 SVIL PALLD WNK2 RCAN2	2.76e-08	195	154	9	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	AKAP6 ANK2 OBSCN SORBS1 MAST4 SVIL PALLD RCAN2	2.63e-07	184	154	8	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 ANK2 OBSCN SORBS1 SVIL PALLD WNK2 RCAN2	2.75e-07	185	154	8	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	AKAP6 ANK2 OBSCN SORBS1 MAST4 SVIL PALLD RCAN2	3.23e-07	189	154	8	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	AKAP6 ANK2 OBSCN SORBS1 MAST4 SVIL PALLD RCAN2	3.36e-07	190	154	8	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	AKAP6 ANK2 OBSCN SORBS1 MAST4 PALLD WNK2 RCAN2	3.36e-07	190	154	8	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	AKAP6 ANK2 OBSCN MAST4 SVIL PALLD WNK2 RCAN2	3.64e-07	192	154	8	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	AKAP6 ANK2 OBSCN SORBS1 MAST4 SVIL PALLD RCAN2	3.79e-07	193	154	8	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	RA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	AKAP6 ANK2 OBSCN SORBS1 MAST4 SVIL PALLD WNK2	3.94e-07	194	154	8	89812fb164065041357bb37a3c2d87028ec3de4e
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	AKAP6 ANK2 OBSCN SORBS1 SVIL PALLD WNK2 RCAN2	4.10e-07	195	154	8	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NPHS1 KIF1A PTPRN2 KCNQ4 RIMBP2 UNC79 WNK2	2.08e-06	169	154	7	96a2aec9acf8a6f966973c035e5ade456cf47772
ToppCell	COVID-19-Heart-CM_+_Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 ANK2 OBSCN SORBS1 PALLD WNK2 RCAN2	2.16e-06	170	154	7	3f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AKAP6 KIF1A KSR2 PTCHD4 RIMBP2 MYO15A DOP1B	2.52e-06	174	154	7	271c51d220842402975d97c86c9acfdbdf62a32c
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGAP32 NSD2 PER2 PNPLA3 ARHGAP21 WNK2 SORL1	3.04e-06	179	154	7	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	AKAP6 OBSCN SORBS1 MAST4 SVIL PALLD RCAN2	3.40e-06	182	154	7	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	AKAP6 ANK2 OBSCN SORBS1 MAST4 PALLD RCAN2	3.78e-06	185	154	7	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	AKAP6 ANK2 OBSCN SORBS1 SVIL PALLD WNK2	4.21e-06	188	154	7	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	RV-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	AKAP6 OBSCN SORBS1 SVIL PALLD RCAN2	4.25e-06	122	154	6	1cb1dd03b2aaedbe04f3ed907568c3b7f54767b3
ToppCell	COVID-19-Heart\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 ANK2 OBSCN SORBS1 PTPRG PALLD RCAN2	4.51e-06	190	154	7	918ad5037881212008f9f69d5df5da91fd01422c
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK2 KIF1A RPN2 HUWE1 PTPRN2 SRRM2 PRRC2B	5.17e-06	194	154	7	0b023de48ed8a550d169bbe954881eb04bf4f981
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANK2 KSR2 LGR4 PTPN13 MAST4 SHANK2 SORL1	5.53e-06	196	154	7	c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANK2 MYO9A LGR4 PTPN13 MAST4 SHANK2 PRKCQ	5.53e-06	196	154	7	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B2_(eMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AKAP6 CARMIL2 ANK2 KIF1A KSR2 TLX2 RIMBP2	5.72e-06	197	154	7	b9478212f14b7888e3abac02995177974ac3bd17
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AKAP6 CARMIL2 ANK2 KIF1A TLX2 RIMBP2 RCAN2	6.11e-06	199	154	7	b4824d3683a4e3025b8e74a0f1755b331b2a0ba7
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP32 SHANK2 PTPRN2 SVIL NKX3-1 WNK2 DOP1B	6.31e-06	200	154	7	0eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LGR4 SHANK2 PER2 PTPRN2 NKX3-1 WNK2 DOP1B	6.31e-06	200	154	7	85c0f038bcfb42669dca2b80273b0f8a1421405e
ToppCell	Influenza_Severe-CD4+_T_naive\|World / Disease group and Cell class	DSC1 RCAN3 TLX2 MAST4 KCNQ4 MYO15A	1.34e-05	149	154	6	ce6552063510aa3e0b9d6e5b531eea67410e7056
ToppCell	Influenza_Severe-CD4+_T_naive\|Influenza_Severe / Disease group and Cell class	DSC1 DOCK9 RCAN3 TLX2 MAST4 MYO15A	1.80e-05	157	154	6	287bdc4e455cd0160261a93d13538e0def49fcd4
ToppCell	severe_influenza-CD4+_T_naive\|severe_influenza / disease group, cell group and cell class (v2)	DSC1 DOCK9 RCAN3 TLX2 MAST4 TRBV7-9	1.87e-05	158	154	6	ff3fa4bd06e01363429aec4bb587b95819bf0fc9
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PTCHD4 SHANK3 SHANK2 GAL3ST3 RIMBP2 UNC79	2.55e-05	167	154	6	9efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCell	Cerebellum-Neuronal-Inhibitory\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PTCHD4 SHANK3 SHANK2 GAL3ST3 RIMBP2 UNC79	2.55e-05	167	154	6	904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_C\|368C / Donor, Lineage, Cell class and subclass (all cells)	THNSL1 CARMIL2 PHF23 CHD8 PDZD7 MOCS3	2.64e-05	168	154	6	0372c06b70f0ba95bf8cd1363ca7c5f31207f094
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ANK2 KIF1A PTPRN2 RIMBP2 UNC79 WNK2	2.73e-05	169	154	6	b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TMEM67 SORBS1 IGDCC4 GGT7 MYMK PALLD	3.21e-05	174	154	6	7fb7bdf62563f2102fb38618b503eb2817b6594f
ToppCell	RV-03._Atrial_Cardiomyocyte\|RV / Chamber and Cluster_Paper	AKAP6 OBSCN SORBS1 SVIL PALLD	3.23e-05	105	154	5	49e16b11f16e83a7d17d162c14bce991201bcc2a
ToppCell	Thalamus-Neuronal-Excitatory\|Thalamus / BrainAtlas - Mouse McCarroll V32	GABRD ARHGAP32 LHX2 SHANK2 PTPRN2 RIMBP2	3.42e-05	176	154	6	d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_NKT-T_cells-T-cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CARMIL2 RCAN3 LAPTM5 ADSL PRKCQ SORL1	3.42e-05	176	154	6	9d4a4dfeebb5a8a0f3ab18c37c8ddc2cd2158575
ToppCell	COVID-19-Heart-CM_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 ANK2 OBSCN SORBS1 PALLD RCAN2	3.42e-05	176	154	6	9df7a124ebafb0087da0cda133a394275d7bed81
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_NKT-T_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CARMIL2 RCAN3 LAPTM5 ADSL PRKCQ SORL1	3.42e-05	176	154	6	bb41e9478373726eb460af764de0277b2d09928e
ToppCell	LPS-antiTNF-Lymphocytic_NKT-T_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CARMIL2 RCAN3 LAPTM5 ADSL PRKCQ SORL1	3.42e-05	176	154	6	ea27e18407b8a13e8212830da859efeb8f158690
ToppCell	LPS-antiTNF-Lymphocytic_NKT-T_cells-T-cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CARMIL2 RCAN3 LAPTM5 ADSL PRKCQ SORL1	3.42e-05	176	154	6	bfbab3c5b738b3b0b1540f2059d0245fbd8c0031
ToppCell	facs-Skin-nan-18m-Lymphocytic-T_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARMIL2 EFCAB6 ITGAL LAPTM5 AHRR GARIN3	3.53e-05	177	154	6	17065d37fd41f04f67282bee00365daa185e8355
ToppCell	facs-Skin-nan-18m-Lymphocytic-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARMIL2 EFCAB6 ITGAL LAPTM5 AHRR GARIN3	3.53e-05	177	154	6	6e45e1a5a894ca2e4ebc5cdb17fdf79e9e188185
ToppCell	facs-Skin-nan-18m-Lymphocytic\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARMIL2 EFCAB6 ITGAL LAPTM5 AHRR GARIN3	3.53e-05	177	154	6	9ff3a77c5c62c8a950c46ca22cd7bde425b84c9a
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	AKAP6 KIF1A RICTOR RABGAP1 MARF1 DYNC1H1	3.53e-05	177	154	6	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AKAP6 ANK2 KIF1A KSR2 PTCHD4 RIMBP2	3.76e-05	179	154	6	b8ca29aebd25ebac441bebd769bbf98c536d3166
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	GABRD RPN2 MTG2 PRPF6 TH MOCS3	3.88e-05	180	154	6	c3d1521ac90f2e3fc31158e6e61907e05c37af39
ToppCell	LPS_only-Lymphocytic_NKT-T_cells-T-cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CARMIL2 RCAN3 LAPTM5 ADSL PRKCQ SORL1	3.88e-05	180	154	6	dcef253f2e97e4436b1b04e8a06a53ff6e64522c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANK2 MYO9A LGR4 PTCHD4 PTPRG PRKCQ	4.00e-05	181	154	6	9d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 ANK2 OBSCN SORBS1 PALLD RCAN2	4.00e-05	181	154	6	719eb532453ab7cd7893726885bc75d74a10b21e
ToppCell	LPS_only-Lymphocytic_NKT-T_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CARMIL2 RCAN3 LAPTM5 ADSL PRKCQ SORL1	4.00e-05	181	154	6	a4347ae554e6dcf03c7001a2b69332b377c7c034
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AKAP6 ANK2 KIF1A TLX2 GAL3ST3 RIMBP2	4.13e-05	182	154	6	be32b5b8153c1053cbb55f1fccfa27c3ee97c1e1
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANK2 MYO9A LGR4 PTCHD4 PTPRG PRKCQ	4.13e-05	182	154	6	eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1-Excitatory_Neuron.Slc17a7.Cbln1-Gpr88_(Medial_entorrhinal_cortex)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ITGAL TLX2 GJA8 C4orf51	4.22e-05	56	154	4	a310f50724ada8da92257c54b18d9214d7415010
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1-Excitatory_Neuron.Slc17a7.Cbln1-Gpr88_(Medial_entorrhinal_cortex)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ITGAL TLX2 GJA8 C4orf51	4.22e-05	56	154	4	4740900fffc892200f3e2480328eb43cb6d19f20
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 ANK2 OBSCN PALLD WNK2 RCAN2	4.39e-05	184	154	6	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ANK2 KIF1A PTPRN2 RIMBP2 UNC79 WNK2	4.66e-05	186	154	6	b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	AKAP6 NBEAL1 SORBS1 NEDD9 SVIL RCAN2	4.94e-05	188	154	6	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|RV / Chamber and Cluster_Paper	AKAP6 ANK2 OBSCN PALLD WNK2 RCAN2	5.09e-05	189	154	6	9c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LGR4 IGDCC4 MST1R PTPRG SVIL RIMBP2	5.09e-05	189	154	6	aadb7a2de4cbe7f0958651f2739bba430b93f5c1
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	DSC1 RUNX2 RCAN3 RNF125 PRKCQ SORL1	5.09e-05	189	154	6	e9df7ecd36bee1fedce23bb188c68a94fa60462c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LGR4 IGDCC4 MST1R PTPRG SVIL RIMBP2	5.09e-05	189	154	6	8977f3295b7df7c7474b3f371de90a82ae4bb50c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANK2 MYO9A LGR4 MAST4 PTPRG SMTNL2	5.24e-05	190	154	6	1cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MYO9A LGR4 NEDD9 PTPRG RIMBP2 PRKCQ	5.24e-05	190	154	6	bf4511395fa97efd1c1cd17cc9bebb0271ee7f0e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MYO9A LGR4 NEDD9 PTPRG RIMBP2 PRKCQ	5.24e-05	190	154	6	b6b8964b4910083499681b5fdf554e127b6a4c4e
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	CHD8 PRPF6 RCAN3 RNF125 PRKCQ SORL1	5.40e-05	191	154	6	9bb6a6b88f351217455765ba07a6acf11fda98f4
ToppCell	control-Myeloid-Neutrophils_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PPP4R1 RICTOR NEDD9 R3HDM4 XPO6 SORL1	5.40e-05	191	154	6	db1b3cd07d7d190155b2d14e82e1d124975fbd0b
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 TTC24 SORBS1 PALLD WNK2 RCAN2	5.40e-05	191	154	6	8e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MYO9A LGR4 NEDD9 PTPRG RIMBP2 PRKCQ	5.40e-05	191	154	6	2fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 TTC24 SORBS1 PALLD WNK2 RCAN2	5.40e-05	191	154	6	60bc1f3efa7bbad5cb7944fe5e049ea79cd1745a
ToppCell	T_cells-Central_memory_CD4+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	CARMIL2 DOCK9 RCAN3 PTPN13 MAST4 SORL1	5.40e-05	191	154	6	25dd538d6a361bd3367c8a1c0dfc9e7003061af3
ToppCell	Control-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	DOCK9 SORBS1 PTPN13 MAST4 SHANK2 PTPRG	5.55e-05	192	154	6	1bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCell	nucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-NK\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ITGAL RNF125 XPO6 OSBPL5 PRKCQ SORL1	5.55e-05	192	154	6	a06d5d3c2537f8d2b1dc6b6f3e88a80b5c2a1850
ToppCell	Control-CD8+_T_naive\|Control / Disease condition and Cell class	DSC1 NBEAL1 OBSCN CARS1 RUNX2 RCAN3	5.72e-05	193	154	6	627d345baf1940218c61907305705298e473dbab
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP32 DSC1 LGR4 EVPL RUNX2 PROM2	5.72e-05	193	154	6	55eab7d2574e9cc2ed8f08e0a7ca7cbf90fb5818
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AKAP6 KIF1A PTPN13 ARHGAP21 CNTN2 RCAN2	5.88e-05	194	154	6	cb0422e7607dbd77204428b7e2c70dfe14a6ca11
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DOCK9 PTPN13 MAST4 SHANK2 PTPRG PRKCQ	5.88e-05	194	154	6	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF1A HUWE1 PTPRN2 SRRM2 MGA DYNC1H1	6.05e-05	195	154	6	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	Control-Lymphoid-T\|Lymphoid / Disease state, Lineage and Cell class	DOCK9 RUNX2 RCAN3 PTPN13 MAST4 RCAN2	6.05e-05	195	154	6	6687e579582d7a239bee80846de0cf827a6f6a62
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-Trm_Th1/Th17\|Liver / Manually curated celltypes from each tissue	RUNX2 RCAN3 NEDD9 PTPN13 TRBV7-9 RCAN2	6.05e-05	195	154	6	480cc62ee1e5b1aaf6b62be6e5afd7a81236a1b0
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AKAP6 CARMIL2 ANK2 KIF1A TLX2 RCAN2	6.05e-05	195	154	6	5a6a5048af638872700b76b7c71a8fa3fb8d3772
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF1A HUWE1 PTPRN2 SRRM2 MGA DYNC1H1	6.05e-05	195	154	6	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AKAP6 CARMIL2 KIF1A KSR2 TLX2 RCAN2	6.23e-05	196	154	6	36b4f08fc038dfde6343ff0869e1a027d882adb5
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn\|World / Primary Cells by Cluster	ANK2 SORBS1 CEP170 ARHGAP21 DOP1B SORL1	6.23e-05	196	154	6	9401bd84798f0ea3e986e94135a9e1dc5643330f
ToppCell	severe-dn_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TTC24 POP4 ZC2HC1B CARS1 RUNX2 RNF125	6.23e-05	196	154	6	14baf176bce5750ef50d6838b748caf68c151e05
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	AKAP6 KIF1A CEP170 TH CNTN2 RCAN2	6.40e-05	197	154	6	2d92b0483d57541aee382dda80e42cf66e813d6b
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KIF1A PTPRN2 SLC6A5 RIMBP2 UNC79 WNK2	6.59e-05	198	154	6	8f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCell	severe-dn_T\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TTC24 POP4 ZC2HC1B CARS1 RUNX2 RNF125	6.59e-05	198	154	6	d4f2213af45ada47e6c62675f468ce05692db507
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-CD8+_T_naive\|Int-URO / Disease, condition lineage and cell class	TTC24 OBSCN CARS1 GSPT2 PRKCQ CDT1	6.59e-05	198	154	6	8c7d00d8c27fb47954d8ac53eebc4582e92b970c
ToppCell	T_cells\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	ITGAL RCAN3 LAPTM5 RNF125 PRKCQ SORL1	6.59e-05	198	154	6	8372ceed063acad0e219644ddd58abbd1354e734
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KIF1A PTPRN2 SLC6A5 RIMBP2 UNC79 WNK2	6.59e-05	198	154	6	e3e0aa3ef20b2370f5b133048510677aaa562dfa
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RUNX2 ITGAL RCAN3 RNF125 PRKCQ SORL1	6.96e-05	200	154	6	cded40d5069a6fdbd90ac9a2a0bbef11727b28d5
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP32 TMC4 SHANK2 PTPRN2 WNK2 DOP1B	6.96e-05	200	154	6	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-dn_T\|COVID-19_Severe / Disease, condition lineage and cell class	TTC24 POP4 CARS1 RUNX2 RNF125 PRKCQ	6.96e-05	200	154	6	d01aa5fccada22f97d8350ad5888df2aadb5bb1c
ToppCell	10x5'v1-week_17-19-Lymphocytic_T-T_NK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TRAV4 DOCK9 RCAN3 R3HDM4 TRBV7-9 PRKCQ	6.96e-05	200	154	6	b7ab3f644e6002635771dccaa192a111b4e0ed5b
Drug	Dacarbazine [4342-03-4]; Up 200; 22uM; PC3; HT_HG-U133A	EFCAB6 HUWE1 LAPTM5 SPTBN5 CLCA1 RNF125 PTPRN2 KCNQ4 AP5Z1 PRRC2B	8.65e-07	197	152	10	4480_UP
Disease	Down syndrome (implicated_via_orthology)	RCAN3 DYRK1B RCAN2 DOP1B	7.73e-07	15	147	4	DOID:14250 (implicated_via_orthology)
Disease	Intellectual Disability	AKAP6 NSD2 INPP5E CHD8 OSGEP SHANK3 TH ADRA2B RNF125 SHANK2 ADSL DYNC1H1	2.68e-06	447	147	12	C3714756
Disease	Profound Mental Retardation	INPP5E CHD8 SHANK3 TH ADRA2B SHANK2 DYNC1H1	6.50e-06	139	147	7	C0020796
Disease	Mental Retardation, Psychosocial	INPP5E CHD8 SHANK3 TH ADRA2B SHANK2 DYNC1H1	6.50e-06	139	147	7	C0025363
Disease	Mental deficiency	INPP5E CHD8 SHANK3 TH ADRA2B SHANK2 DYNC1H1	6.50e-06	139	147	7	C0917816
Disease	proteinuria (implicated_via_orthology)	NPHS1 TMEM67 OSGEP HPS5	1.46e-05	30	147	4	DOID:576 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	ARHGAP32 CHD9 CHD8 TSC2 SHANK3 SHANK2	1.18e-04	152	147	6	DOID:0060041 (implicated_via_orthology)
Disease	COACH syndrome	TMEM67 INPP5E	1.47e-04	4	147	2	C1857662
Disease	EPILEPSY, FAMILIAL ADULT MYOCLONIC, 1	ADRA2B CNTN2	1.47e-04	4	147	2	C1832841
Disease	Brain Diseases	TSC2 TH SLC6A5	2.57e-04	25	147	3	C0006111
Disease	Encephalopathies	TSC2 TH SLC6A5	3.25e-04	27	147	3	C0085584
Disease	nephronophthisis (is_implicated_in)	TMEM67 IQCB1	3.65e-04	6	147	2	DOID:12712 (is_implicated_in)
Disease	sexual dimorphism measurement	KIF1A PHF23 RPN2 INPP5E LGR4 TSC2 SIPA1 GGT7 SPTBN5 TH CATSPER1 PTPRG ZNF341 MYMK MGA	4.31e-04	1106	147	15	EFO_0021796
Disease	CHARGE syndrome (implicated_via_orthology)	CHD9 CHD8	5.09e-04	7	147	2	DOID:0050834 (implicated_via_orthology)
Disease	Neurodevelopmental delay	NSD2 CARS1	5.09e-04	7	147	2	C4022738
Disease	Joubert syndrome (implicated_via_orthology)	INPP5E TOGARAM1	5.09e-04	7	147	2	DOID:0050777 (implicated_via_orthology)
Disease	hereditary spastic paraplegia (is_implicated_in)	KIF1A AP5Z1	5.09e-04	7	147	2	DOID:2476 (is_implicated_in)
Disease	renin measurement	NBEAL1 CNTN2	6.77e-04	8	147	2	EFO_0010616
Disease	colon cancer (is_implicated_in)	ATR RICTOR PTPN13	7.67e-04	36	147	3	DOID:219 (is_implicated_in)
Disease	Autism Spectrum Disorders	CHD8 SHANK3 GLRA2 NEMF	8.75e-04	85	147	4	C1510586
Disease	dentate gyrus volume measurement	PKD1L1 RABGAP1 MAST4	9.71e-04	39	147	3	EFO_0010083
Disease	Joubert syndrome (is_implicated_in)	INPP5E TOGARAM1	1.08e-03	10	147	2	DOID:0050777 (is_implicated_in)
Disease	Cystic Kidney Diseases	TMEM67 ALG9	1.32e-03	11	147	2	C1691228
Disease	red blood cell density measurement	TSSK6 ATR EP400 MYO9A RICTOR SORBS1 GJA8 SLC34A1 C2orf42 CDT1 MYO15A CNTN2	1.56e-03	880	147	12	EFO_0007978
Disease	Autistic Disorder	KIF1A CHD8 TSC2 SHANK3 SHANK2 ADSL	2.02e-03	261	147	6	C0004352
Disease	Arthritis, Psoriatic	RUNX2 MEFV	2.16e-03	14	147	2	C0003872
Disease	R-warfarin measurement	ANK2 ITGAL XPO6 ZFYVE26 ARHGAP21 VWA5B1	2.18e-03	265	147	6	EFO_0803324
Disease	Ciliopathies	TMEM67 TSC2 CIBAR1 IQCB1	2.27e-03	110	147	4	C4277690
Disease	macula measurement	ARHGAP32 MYO9A NEDD9 DYRK1B SORL1	2.62e-03	189	147	5	EFO_0008375
Disease	coronary artery disease	KIF1A NBEAL1 DOCK9 KSR2 HSF2BP RUNX2 SIPA1 GGT7 NEDD9 MAST4 PNPLA3 PALLD ARHGAP21 WNK2	2.63e-03	1194	147	14	EFO_0001645
Disease	alcoholic liver cirrhosis	TMC4 PNPLA3	3.19e-03	17	147	2	EFO_1000802
Disease	bacteriemia	PTPRG PALLD	3.19e-03	17	147	2	EFO_0003033
Disease	Chronic myeloproliferative disorder	ATR CDT1	3.99e-03	19	147	2	C1292778
Disease	cerebral microbleeds	CARS1 OSBPL5	3.99e-03	19	147	2	EFO_0010059
Disease	diacylglycerol 38:3 measurement	TMC4 PNPLA3	3.99e-03	19	147	2	EFO_0020065
Disease	Disorder of eye	TMEM67 PDZD7 PRPF6 GPR179 IQCB1	4.28e-03	212	147	5	C0015397
Disease	Familial aplasia of the vermis	TMEM67 INPP5E	4.42e-03	20	147	2	cv:C0431399
Disease	Microcephaly	NSD2 CARS1 DYNC1H1	4.60e-03	67	147	3	C0025958
Disease	skin hydration measurement	PKD1L1 ARHGAP21	4.86e-03	21	147	2	EFO_0009586
Disease	Joubert syndrome 1	TMEM67 INPP5E	4.86e-03	21	147	2	C4551568
Disease	Arthrogryposis	MYO9A DYNC1H1	4.86e-03	21	147	2	C0003886

Protein segments in the cluster

Peptide	Gene	Start	Entry
TRLPTAASASKQAAR	PTPRG	536	P23470
LLRAKPRADTAATAD	AHRR	291	A9YTQ3
RLPNSTTAFVRKDAL	C2orf42	411	Q9NWW7
KFSPRIRANSISRLS	CEP170	1196	Q5SW79
ARPAAAKLKASRLFQ	EP400	1451	Q96L91
NLRQAAIDRFSKPDS	CHD8	1186	Q9HCK8
LFSAVLRALFRKSDP	CATSPER1	596	Q8NEC5
SLSASPAQDKRLFLD	NEDD9	391	Q14511
LAYRPFLDASRSSKL	ALG9	561	Q9H6U8
RLDAPRLETKSLSSS	ALKBH5	286	Q6P6C2
VFSRTKSRAAPAALQ	CARMIL2	441	Q6F5E8
KSRAAPAALQLFLSR	CARMIL2	446	Q6F5E8
EKALSQLALRSAAPS	CDT1	376	Q9H211
DPALRSKLVRLSSDS	BCL2L12	231	Q9HB09
SAKLPALASVASARE	ADRA2B	231	P18089
SRAKSIITSDSLAPR	ACSM5	161	Q6NUN0
TKLASRSQDLIPRAS	AP5Z1	706	O43299
KNRAIETAPLSFRTL	CENPP	251	Q6IPU0
AAALSSLRALRKEFV	CDAN1	36	Q8IWY9
AFRDATSAPLRKLSV	DYRK1B	36	Q9Y463
KPRTRDFATAAAELR	IGDCC4	316	Q8TDY8
FSALSKPGISSELLR	NBEAL1	1471	Q6ZS30
PALASSQVKRLSASR	R3HDM4	31	Q96D70
INFSNPKSAARARIE	RCAN2	56	Q14206
RINFSKPEAAARARI	RCAN3	91	Q9UKA8
VPSSSRSLLDFRRKV	PTPRN2	916	Q92932
RNSEARAFKPETISA	ANAPC1	1726	Q9H1A4
PKKSDSNASFLRAAR	ANK2	26	Q01484
AFRRSAKQTPLSATA	RABGAP1	266	Q9Y3P9
RAPFKGSAAARSVLL	NPHS1	596	O60500
EKPRLSFADRALINS	PRKCQ	671	Q04759
LFRSVKDTDLSRNIP	NEMF	1046	O60524
SAFSIVPRRAAKSSR	MGA	2251	Q8IWI9
RSAKSSFSLLAPIRS	INPP5E	251	Q9NRR6
SFSLLAPIRSKDVRS	INPP5E	256	Q9NRR6
RARPASLQKSLSVAS	GPR179	831	Q6PRD1
RPRARSLSKASTAIN	MYO15A	121	Q9UKN7
PKRSALLAAFQSESF	DOP1B	1156	Q9Y3R5
NLSLLSARSFPRKAS	KSR2	636	Q6VAB6
SLVKSRPEDQRSSFL	HPS5	896	Q9UPZ3
FRASLRLKPRTSAED	KCNQ4	491	P56696
REPLSSAFSRKLNVN	GSPT2	41	Q8IYD1
ANVPALRSSDKRKAT	PER2	611	O15055
TDPDSFLKSARLQRL	GGT7	56	Q9UJ14
FLKSARLQRLPSSSS	GGT7	61	Q9UJ14
RSLQAESKCAFLRAP	KCNG2	236	Q9UJ96
RRLDSALSESPKTAL	PDZD7	406	Q9H5P4
KAEATPRSILRSSLN	PNPLA3	441	Q9NST1
QSRLKASAVESLRPS	EVPL	496	Q92817
PLKKRNRASTAASSA	NSD2	596	O96028
LRERFSAASSASKIL	MPHOSPH9	526	Q99550
RAKSEAPAISSAIDR	LHX2	21	P50458
LAAKDFVNLRSLSVP	LGR4	451	Q9BXB1
SARSSLPRASAIKAL	GABRD	296	O14764
KTAANLDSATEPRAR	MEFV	266	O15553
LDRFARVLKISNDPS	OSGEP	161	Q9NPF4
KLASFFLSRVDALSP	PELP1	216	Q8IZL8
RFSQLSELPRSDTLK	ARHGAP32	191	A7KAX9
KDTPALARLFLASLA	HUWE1	2126	Q7Z6Z7
AASFDIPKEKRLRAS	RICTOR	456	Q6R327
ASPREKLSSAFQIAL	SLC34A1	461	Q06495
SAALRVTEKPSVFSR	OBSCN	3086	Q5VST9
LPSGEARLKAFSTRS	OR52R1	231	Q8NGF1
FPKKASRTARIASDE	PALLD	881	Q8WX93
KAAQRSAPSRATALV	KCTD18	321	Q6PI47
AASSRLAAIPAALAR	GAL3ST3	271	Q96A11
DLAAKASPAASALIR	ATR	1001	Q13535
LRQAAIDRFSKPDSD	CHD9	1236	Q3L8U1
LLPASAETRKFTRAL	DOCK9	6	Q9BZ29
SSPRQALTDFLLARK	COG1	221	Q8WTW3
SSRLDIVRANSKSPL	CIBAR1	231	A1XBS5
ANPTLSSLDVKRILF	EFCAB6	51	Q5THR3
DDARPLSRLSKASSR	GJA8	411	P48165
AEDTRLFAPSIKARF	CNTN2	231	Q02246
KRIDTISRAAFPLAF	GLRA2	416	P23416
FSKLVASRQVSPLLA	MARF1	736	Q9Y4F3
TASLKELSLPRRGSF	MAST4	211	O15021
LKSASLIRSSDPAFR	DSC1	56	Q08554
KLPSAVIALQRSFRS	IQCB1	316	Q15051
KDRAATSPALFNRCV	DYNC1H1	3076	Q14204
RDFLATVPTFRKAAT	GRK7	71	Q8WTQ7
REALARFARAFSTPK	SAC3D1	301	A6NKF1
AAFAKRLARLALTAP	NOC4L	366	Q9BVI4
SLLFRLSKEAPGSAR	PKD1L1	2011	Q8TDX9
SPLTSQEFDLIRRKA	C4orf51	16	C9J302
AKAFSAAASLRRLNS	MOCS3	136	O95396
AKLPASRSIRNLFGS	KIF1A	1296	Q12756
SLQELFRKVSLADPA	PTPN13	31	Q12923
KRATRQLLSALTDPS	OSBPL5	111	Q9H0X9
IRKNGPARLLSSSAS	TMEM67	851	Q5HYA8
ASKISSFLRSLRATP	GARIN3	531	Q8TC56
SSLKFSLPVDLAVRQ	RUNDC1	591	Q96C34
RQKLDDSKPSLFSDR	RUNX2	231	Q13950
KSASEFRSSLPLQRI	HSF2BP	291	O75031
LSAKPTFLSRSGSAR	RIMBP2	131	O15034
ARDSLALARPKSSDV	SORL1	121	Q92673
LAALQPAKERRSSSS	SRRM2	2521	Q9UQ35
ISADRLSEKRSPNDF	CARS1	306	P49589
KLSALFINLISDPSR	PPP4R1	291	Q8TF05
LAEKRSSLTTAALPF	TBC1D25	151	Q3MII6
FLASANACRRPELKS	SVIL	601	O95425
KLSSPRAQAASAALR	SLC6A5	81	Q9Y345
LKLASRSRASSSKFP	LAPTM5	121	Q13571
ARRLLAKARSSAPTA	PRPF6	661	O94906
SNLPKARAALTSART	PSMD11	181	O00231
AKIERSLASSLFPLD	PTCHD4	81	Q6ZW05
RLADFAKERASLPTL	ADSL	141	P30566
TAFRSKRDEALPSLT	ERCC5	121	P28715
RSFSGLNSRLKATPS	PRRC2A	2081	P48634
RAEAFVRAFLKRSTP	POP4	26	O95707
APASTDDLFARKLRQ	SIPA1	16	Q96FS4
GKSSLLRAISNARPA	MTG2	236	Q9H4K7
SLPALKEEAFSRASL	NKX3-1	196	Q99801
RPSAAATAAARKRAL	NOM1	161	Q5C9Z4
LRAPTAAERRKAFST	OR6T1	226	Q8NGN1
KVARVANPRLDTFSR	POLR1C	271	O15160
KCEANLRVSFSPARS	ITGAL	776	P20701
ENSSRALAFLRAKVP	SPTBN5	116	Q9NRC6
KRLEARRNSPAFLST	SHANK2	1091	Q9UPX8
IPESNASFRKRLTRS	AKAP6	1711	Q13023
SDRDTLAKRLPAAAS	CLCA1	366	A8K7I4
ATFDSPATLKTRRAK	ZNF341	291	Q9BYN7
RAFLLASKAPQTRDT	TTC24	61	A2A3L6
KSAPASATARALERR	RNF125	11	Q96EQ8
ALTRLPDTLFSKALN	PHLPP2	581	Q6ZVD8
AFSASLFAPSKPQRR	SHANK3	936	Q9BYB0
AKLNLSVRALESSAP	PROM2	681	Q8N271
RLKASLDRPFTNLES	RPN2	36	P04844
VFLARRAVALTSTKP	TMC4	696	Q7Z404
ATADPLRARSISAVK	SORBS1	26	Q9BX66
KAASAAARGFPLRTL	WBP2NL	131	Q6ICG8
ATKSPRKAAAAAARL	CREBZF	206	Q9NS37
TEKASVNAELLPRFR	MYCBPAP	641	Q8TBZ2
LAKRSFSSQRPVVDR	PRRC2B	1416	Q5JSZ5
LPRTSEAQARKALFE	SMTNL2	306	Q2TAL5
LRERKLAQTFSPSID	THNSL1	551	Q8IYQ7
FSRLQAPDSATLLEK	PHF23	116	Q9BUL5
DAVPAALQSLRFRVK	ZMYND12	106	Q9H0C1
RRVFNPAQTAAKLAS	ZC2HC1B	146	Q5TFG8
KSRLLSDRFSAERPK	TRBV7-9	76	P04435
KALIAELLQFSPSAR	TSSK6	241	Q9BXA6
FRPFTSDSLAAIEKR	SCN11A	16	Q9UI33
LSFDLAPALVDSKRR	TOGARAM1	511	Q9Y4F4
KATAFLQRPSRAGSL	WNK2	1876	Q9Y3S1
SALSRDYRNLKPSAV	XPO6	756	Q96QU8
RELLVSSIFAAASRK	ARHGAP21	1406	Q5T5U3
VASLFIPADRKSSTL	TRAV4	76	A0A0B4J268
FPVKDASLRSRLALQ	ZFYVE26	1466	Q68DK2
FSPRSVSIRRLKADA	MST1R	211	Q04912
DSFRARSTSLNERPK	TSC2	931	P49815
RFAKDRLTAALSPFS	TLX2	126	O43763
RADAAPSARSAKSII	VWA5B1	246	Q5TIE3
NATRSLLEPFSKLLS	UNC79	2211	Q9P2D8
LFSPRATKPSALSRA	TH	116	P07101
ASNLDPAALTLVSRK	GAS8	391	O95995
LAFLPTVSIAAKRRF	MYMK	16	A6NI61
IRSNAEKLPLRFSDV	MYO9A	916	B2RTY4