Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	zinc ion binding	PIAS4 RNF14 TET2 RAG1 PIAS3 P2RX7 SYTL4 CPO GRIN2B ERI2 MMP16 PIAS2 TRIM59	3.81e-05	891	78	13	GO:0008270
GeneOntologyMolecularFunction	ganglioside GM1 binding	PSAP EPDR1	4.51e-05	3	78	2	GO:1905573
GeneOntologyMolecularFunction	SUMO ligase activity	PIAS4 PIAS3 PIAS2	6.23e-05	20	78	3	GO:0061665
GeneOntologyMolecularFunction	ganglioside binding	PSAP EPDR1	1.49e-04	5	78	2	GO:0035594
GeneOntologyMolecularFunction	SUMO transferase activity	PIAS4 PIAS3 PIAS2	3.73e-04	36	78	3	GO:0019789
GeneOntologyMolecularFunction	scaffold protein binding	PSAP P2RX7 GRIN2B MAP3K7	4.83e-04	93	78	4	GO:0097110
GeneOntologyMolecularFunction	transition metal ion binding	PIAS4 RNF14 TET2 RAG1 PIAS3 P2RX7 SYTL4 CPO GRIN2B ERI2 MMP16 PIAS2 TRIM59	6.55e-04	1189	78	13	GO:0046914
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	PIAS4 RNF14 RAG1 PIAS3 BCOR CBL PIAS2 TRIM59	8.60e-04	512	78	8	GO:0019787
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	PIAS4 RNF14 RAG1 PIAS3 CBL PIAS2 TRIM59	9.29e-04	398	78	7	GO:0061659
GeneOntologyMolecularFunction	enzyme activator activity	PPP2R5E PSAP P2RX7 ALS2 TNFRSF10A MMP16 DEPDC1B ALK DNTTIP1	1.02e-03	656	78	9	GO:0008047
GeneOntologyMolecularFunction	aminoacyltransferase activity	PIAS4 RNF14 RAG1 PIAS3 BCOR CBL PIAS2 TRIM59	1.10e-03	532	78	8	GO:0016755
GeneOntologyMolecularFunction	glycosphingolipid binding	PSAP EPDR1	1.14e-03	13	78	2	GO:0043208
HumanPheno	Bone pain	TET2 PSAP BCOR CBL ALK	4.26e-05	87	24	5	HP:0002653
HumanPheno	Broad nasal tip	SOX4 PIK3CD SETBP1 BCOR MAP3K7 KIAA0753	7.10e-05	159	24	6	HP:0000455
HumanPheno	Hypersplenism	TET2 PSAP CBL	9.94e-05	20	24	3	HP:0001971
HumanPheno	Abnormal spleen physiology	TET2 PSAP CBL	9.94e-05	20	24	3	HP:0025409
HumanPheno	Lymphadenopathy	TET2 RAG1 PIK3CD DLEC1 BCOR CBL ALK	1.01e-04	248	24	7	HP:0002716
Domain	ZnF_C2HC	FAM90A14 FAM90A1 FAM90A7 FAM90A18 FAM90A9 FAM90A8	6.63e-08	55	72	6	SM00343
Domain	Znf_CCHC	FAM90A14 FAM90A1 FAM90A7 FAM90A18 FAM90A9 FAM90A8	6.63e-08	55	72	6	IPR001878
Domain	PINIT	PIAS4 PIAS3 PIAS2	2.19e-07	4	72	3	IPR023321
Domain	PINIT	PIAS4 PIAS3 PIAS2	2.19e-07	4	72	3	PS51466
Domain	PINIT	PIAS4 PIAS3 PIAS2	2.19e-07	4	72	3	PF14324
Domain	zf-MIZ	PIAS4 PIAS3 PIAS2	1.90e-06	7	72	3	PF02891
Domain	ZF_SP_RING	PIAS4 PIAS3 PIAS2	1.90e-06	7	72	3	PS51044
Domain	Znf_MIZ	PIAS4 PIAS3 PIAS2	3.03e-06	8	72	3	IPR004181
Domain	-	PIAS4 RNF14 RAG1 PIAS3 SYTL4 WDFY3 CBL PIAS2 TRIM59	5.51e-05	449	72	9	3.30.40.10
Domain	Znf_RING/FYVE/PHD	PIAS4 RNF14 RAG1 PIAS3 SYTL4 WDFY3 CBL PIAS2 TRIM59	6.53e-05	459	72	9	IPR013083
Domain	-	PIAS4 PIAS3 PIAS2	6.95e-05	21	72	3	1.10.720.30
Domain	SAP	PIAS4 PIAS3 PIAS2	8.03e-05	22	72	3	PF02037
Domain	SAP	PIAS4 PIAS3 PIAS2	9.20e-05	23	72	3	SM00513
Domain	SAP	PIAS4 PIAS3 PIAS2	1.19e-04	25	72	3	PS50800
Domain	SAP_dom	PIAS4 PIAS3 PIAS2	1.19e-04	25	72	3	IPR003034
Domain	TIL	MUC5B TECTA	9.43e-04	12	72	2	PF01826
Domain	C8	MUC5B TECTA	9.43e-04	12	72	2	PF08742
Domain	Unchr_dom_Cys-rich	MUC5B TECTA	1.11e-03	13	72	2	IPR014853
Domain	C8	MUC5B TECTA	1.11e-03	13	72	2	SM00832
Domain	MORN	ALS2 MORN3	1.29e-03	14	72	2	SM00698
Domain	TIL_dom	MUC5B TECTA	1.29e-03	14	72	2	IPR002919
Domain	MORN	ALS2 MORN3	1.49e-03	15	72	2	IPR003409
Domain	MORN	ALS2 MORN3	1.49e-03	15	72	2	PF02493
Domain	VWD	MUC5B TECTA	1.70e-03	16	72	2	SM00216
Domain	VWF_type-D	MUC5B TECTA	1.70e-03	16	72	2	IPR001846
Domain	VWFD	MUC5B TECTA	1.70e-03	16	72	2	PS51233
Domain	AT_hook	CECR2 SETBP1	1.70e-03	16	72	2	PF02178
Domain	VWD	MUC5B TECTA	1.70e-03	16	72	2	PF00094
Domain	VWC_out	MUC5B TECTA	2.40e-03	19	72	2	SM00215
Domain	Znf_RING_CS	RNF14 RAG1 CBL TRIM59	3.63e-03	163	72	4	IPR017907
Domain	HMGI/Y_DNA-bd_CS	CECR2 SETBP1	6.34e-03	31	72	2	IPR000637
Domain	RING	RNF14 RAG1 SYTL4 CBL TRIM59	6.45e-03	305	72	5	SM00184
Pathway	KEGG_JAK_STAT_SIGNALING_PATHWAY	PIAS4 PIAS3 PIK3CD CBL PIAS2 LEPR	1.71e-05	155	50	6	M17411
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_FACTORS	PIAS4 PIAS3 PIAS2	2.28e-05	16	50	3	MM14938
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_FACTORS	PIAS4 PIAS3 PIAS2	4.59e-05	20	50	3	M27237
Pathway	REACTOME_REGULATION_OF_SIGNALING_BY_CBL	PIK3CD CBL HCK	5.34e-05	21	50	3	MM15633
Pathway	REACTOME_REGULATION_OF_SIGNALING_BY_CBL	PIK3CD CBL HCK	6.17e-05	22	50	3	M903
Pathway	REACTOME_SUMOYLATION_OF_INTRACELLULAR_RECEPTORS	PIAS4 PIAS3 PIAS2	1.29e-04	28	50	3	MM15042
Pathway	REACTOME_SUMOYLATION_OF_INTRACELLULAR_RECEPTORS	PIAS4 PIAS3 PIAS2	1.59e-04	30	50	3	M27323
Pathway	REACTOME_SIGNALING_BY_CSF1_M_CSF_IN_MYELOID_CELLS	PIK3CD CBL HCK	1.76e-04	31	50	3	M46423
Pathway	KEGG_SMALL_CELL_LUNG_CANCER	PIAS4 PIAS3 PIK3CD PIAS2	2.19e-04	84	50	4	M3228
Pathway	WP_ANDROGEN_RECEPTOR_SIGNALING	PIAS4 RNF14 PIAS3 PIAS2	2.98e-04	91	50	4	M39700
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY	PIK3CD ALK	3.41e-04	8	50	2	M47405
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS	PIAS4 PIAS3 PIAS2	3.78e-04	40	50	3	MM15000
Pathway	REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING	PIK3CD CBL HCK	4.07e-04	41	50	3	MM15162
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS	PIAS4 PIAS3 PIAS2	5.02e-04	44	50	3	M27295
Pathway	REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING	PIK3CD CBL HCK	6.49e-04	48	50	3	M914
Pathway	KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY	PIK3CD CBL	6.64e-04	11	50	2	M47406
Pathway	WP_IL3_SIGNALING	PIK3CD CBL HCK	6.90e-04	49	50	3	M39722
Pathway	REACTOME_SUMOYLATION_OF_IMMUNE_RESPONSE_PROTEINS	PIAS4 PIAS3	7.95e-04	12	50	2	M27404
Pathway	REACTOME_SUMOYLATION_OF_IMMUNE_RESPONSE_PROTEINS	PIAS4 PIAS3	7.95e-04	12	50	2	MM15157
Pathway	WP_INTERFERON_TYPE_I_SIGNALING	PIAS3 PIK3CD CBL	9.17e-04	54	50	3	M39435
Pathway	KEGG_PATHWAYS_IN_CANCER	PIAS4 PIAS3 PIK3CD CBL VEGFD PIAS2	9.70e-04	325	50	6	M12868
Pubmed	Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events.	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A2P FAM90A1 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16	5.50e-26	25	81	12	17684299
Pubmed	Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds.	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A2P FAM90A7 FAM90A9 FAM90A8 FAM90A16	2.94e-21	23	81	10	18602769
Pubmed	Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A26 FAM90A23 FAM90A1 FAM90A7 FAM90A9 FAM90A8 LEPR	1.66e-13	164	81	11	22967998
Pubmed	PIAS proteins are involved in the SUMO-1 modification, intracellular translocation and transcriptional repressive activity of RET finger protein.	PIAS4 PIAS3 PIAS2	1.21e-07	5	81	3	15907835
Pubmed	SUMOylation of RORalpha potentiates transcriptional activation function.	PIAS4 PIAS3 PIAS2	2.42e-07	6	81	3	19041634
Pubmed	A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis.	PIAS4 PIAS3 PIAS2	2.42e-07	6	81	3	23704280
Pubmed	Molecular characterization of a testis-specific estrogen sulfotransferase and aberrant liver expression in obese and diabetogenic C57BL/KsJ-db/db mice.	RAG1 HCK LEPR	4.23e-07	7	81	3	7750469
Pubmed	Inhibition of Stat1-mediated gene activation by PIAS1.	PIAS4 PIAS3 PIAS2	4.23e-07	7	81	3	9724754
Pubmed	Interaction of protein inhibitor of activated STAT (PIAS) proteins with the TATA-binding protein, TBP.	PIAS4 PIAS3 PIAS2	6.76e-07	8	81	3	16522640
Pubmed	Sumoylation of FOXP2 Regulates Motor Function and Vocal Communication Through Purkinje Cell Development.	PIAS4 PIAS3 PIAS2	1.98e-06	11	81	3	27009683
Pubmed	HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells.	PIAS4 PIAS3 PIAS2	1.98e-06	11	81	3	28842558
Pubmed	Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis.	PIAS4 PIAS3 PIAS2	2.64e-06	12	81	3	30612578
Pubmed	Foxp1 regulation of neonatal vocalizations via cortical development.	PIAS4 PIAS3 PIAS2	3.42e-06	13	81	3	29138280
Pubmed	Large-scale structural analysis of the classical human protein tyrosine phosphatome.	GRIN2B CBL ALK LEPR	4.51e-06	47	81	4	19167335
Pubmed	Control of Tissue-Resident Invariant NKT Cells by Vitamin A Metabolites and P2X7-Mediated Cell Death.	RAG1 P2RX7	5.36e-06	2	81	2	31308092
Pubmed	Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells.	RAG1 PIK3CD	5.36e-06	2	81	2	17082571
Pubmed	Purinergic P2X7 receptor drives T cell lineage choice and shapes peripheral γδ cells.	RAG1 P2RX7	5.36e-06	2	81	2	22649196
Pubmed	Isolation and characterization of a novel, transforming allele of the c-Cbl proto-oncogene from a murine macrophage cell line.	CBL HCK	5.36e-06	2	81	2	12032836
Pubmed	Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis.	RAG1 LEPR	5.36e-06	2	81	2	16380490
Pubmed	Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia.	TET2 CBL	5.36e-06	2	81	2	20008299
Pubmed	Internalization and down-regulation of the ALK receptor in neuroblastoma cell lines upon monoclonal antibodies treatment.	CBL ALK	5.36e-06	2	81	2	22479414
Pubmed	Mutations of the TET2 and CBL genes: novel molecular markers in myeloid malignancies.	TET2 CBL	5.36e-06	2	81	2	20195608
Pubmed	TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives.	TET2 CSMD1	5.36e-06	2	81	2	25695618
Pubmed	Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome.	TET2 BCOR	5.36e-06	2	81	2	30228234
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	PPP2R5E PSAP P2RX7 SPOPL PIK3CD OSBPL11 BOP1 ALS2 EPDR1 BCOR TRIM59 KIAA0753	7.73e-06	1084	81	12	11544199
Pubmed	c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance.	TNFRSF10A CBL	1.60e-05	3	81	2	19932172
Pubmed	Hereditary spastic paraplegias: identification of a novel SPG57 variant affecting TFG oligomerization and description of HSP subtypes in Sudan.	SACS ALS2	1.60e-05	3	81	2	27601211
Pubmed	TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal.	TET2 RAG1	1.60e-05	3	81	2	37541212
Pubmed	Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities.	PIAS4 PIAS2	1.60e-05	3	81	2	15976810
Pubmed	Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells.	RAG1 CBL	1.60e-05	3	81	2	34630435
Pubmed	Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation.	CBL HCK	1.60e-05	3	81	2	11896602
Pubmed	Methylation of TET2, CBL and CEBPA in Ph-negative myeloproliferative neoplasms.	TET2 CBL	1.60e-05	3	81	2	20671051
Pubmed	PIAS genes as disease markers in bipolar disorder.	PIAS3 PIAS2	1.60e-05	3	81	2	30861611
Pubmed	A ligand-inducible anaplastic lymphoma kinase chimera is endocytosis impaired.	CBL ALK	1.60e-05	3	81	2	14691459
Pubmed	Expression of leptin receptor in nasal polyps: leptin as a mucosecretagogue.	MUC5B LEPR	1.60e-05	3	81	2	20422702
Pubmed	PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases.	PIAS3 PIAS2	1.60e-05	3	81	2	12077349
Pubmed	STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth.	RAG1 LEPR	1.60e-05	3	81	2	31761565
Pubmed	Cloning and analysis of a murine PIAS family member, PIASgamma, in developing skin and neurons.	PIAS4 PIAS3	1.60e-05	3	81	2	10854042
Pubmed	Leptin metabolically licenses T cells for activation to link nutrition and immunity.	RAG1 LEPR	1.60e-05	3	81	2	24273001
Pubmed	Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3.	SLC22A14 DLEC1	1.60e-05	3	81	2	10213508
Pubmed	Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement.	CBL HCK	1.60e-05	3	81	2	12652654
Pubmed	Specification of SUMO1- and SUMO2-interacting motifs.	PIAS4 PIAS3 PIAS2	1.82e-05	22	81	3	16524884
Pubmed	The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses.	RAG1 P2RX7	3.20e-05	4	81	2	21357533
Pubmed	SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells.	RAG1 CBL	3.20e-05	4	81	2	38019655
Pubmed	Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors.	RAG1 P2RX7	3.20e-05	4	81	2	22948816
Pubmed	Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase.	CBL HCK	3.20e-05	4	81	2	8995358
Pubmed	The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.	CBL HCK	3.20e-05	4	81	2	10092522
Pubmed	Age-related loss of chromosome Y is associated with levels of sex hormone binding globulin and clonal hematopoiesis defined by TET2, TP53, and CBL mutations.	TET2 CBL	3.20e-05	4	81	2	37083525
Pubmed	Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses.	RAG1 LEPR	3.20e-05	4	81	2	37863051
Pubmed	Elevated gene expression of glutamate receptors in noradrenergic neurons from the locus coeruleus in major depression.	GRIN2B GRM4	3.20e-05	4	81	2	24925192
Pubmed	Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ.	RAG1 PIK3CD	3.20e-05	4	81	2	29038423
Pubmed	The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses.	RAG1 LEPR	3.20e-05	4	81	2	34031386
Pubmed	Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells.	PIAS4 PIAS2	3.20e-05	4	81	2	11439351
Pubmed	Neuroblastoma Formation Requires Unconventional CD4 T Cells and Arginase-1-Dependent Myeloid Cells.	RAG1 ALK	3.20e-05	4	81	2	34301764
Pubmed	DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor.	PIAS3 PIAS2	3.20e-05	4	81	2	11477070
Pubmed	Srsf2P95H/+ co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia-like disease in mice.	TET2 CBL	3.20e-05	4	81	2	36271153
Pubmed	Purinergic Signaling as a Regulator of Th17 Cell Plasticity.	RAG1 P2RX7	3.20e-05	4	81	2	27322617
Pubmed	RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation.	CBL HCK	3.20e-05	4	81	2	11239464
Pubmed	Generation of a common innate lymphoid cell progenitor requires interferon regulatory factor 2.	RAG1 IRF2	3.20e-05	4	81	2	30783658
Pubmed	Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators.	PIAS4 PIAS2	3.20e-05	4	81	2	11877418
Pubmed	SRY-Box Containing Gene 4 Promotes Liver Steatosis by Upregulation of SREBP-1c.	SOX4 LEPR	3.20e-05	4	81	2	30181160
Pubmed	Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function.	RAG1 MAP3K7	3.20e-05	4	81	2	22308391
Pubmed	O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release.	GRIN2B MAP3K7	3.20e-05	4	81	2	22307082
Pubmed	Leptin modulates pancreatic β-cell membrane potential through Src kinase-mediated phosphorylation of NMDA receptors.	GRIN2B LEPR	3.20e-05	4	81	2	33037073
Pubmed	IFN regulatory factor-2 deficiency revealed a novel checkpoint critical for the generation of peripheral NK cells.	RAG1 IRF2	3.20e-05	4	81	2	15879093
Pubmed	c-Cbl shRNA-expressing adenovirus sensitizes TRAIL-induced apoptosis in prostate cancer DU-145 through increases of DR4/5.	TNFRSF10A CBL	3.20e-05	4	81	2	23306613
Pubmed	Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis.	TET2 CBL	3.20e-05	4	81	2	22905207
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TET2 CECR2 SETBP1 JOSD1 BOP1 OXSR1 ERI2 BCOR	3.30e-05	529	81	8	14621295
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	SOX4 PIAS4 RNF14 PIAS3 SPOPL BOP1 VSX2 CBL TRIM59	4.08e-05	709	81	9	22988430
Pubmed	DNA demethylation fine-tunes IL-2 production during thymic regulatory T cell differentiation.	TET2 RAG1	5.33e-05	5	81	2	36880575
Pubmed	Phagocytosis in macrophages lacking Cbl reveals an unsuspected role for Fc gamma receptor signaling and actin assembly in target binding.	CBL HCK	5.33e-05	5	81	2	19380812
Pubmed	Protein inhibitor of activated STAT3 (PIAS3) protein promotes SUMOylation and nuclear sequestration of the intracellular domain of ErbB4 protein.	PIAS4 PIAS3	5.33e-05	5	81	2	22584572
Pubmed	Loss of TET2 and TET3 in regulatory T cells unleashes effector function.	TET2 RAG1	5.33e-05	5	81	2	31043609
Pubmed	Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter.	TET2 P2RX7	5.33e-05	5	81	2	29858571
Pubmed	Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and phosphatidylinositol 3-kinase.	CBL HCK	5.33e-05	5	81	2	10799548
Pubmed	PIAS proteins as repressors of Oct4 function.	PIAS4 PIAS3	5.33e-05	5	81	2	17991485
Pubmed	Regulation of cardiac specific nkx2.5 gene activity by small ubiquitin-like modifier.	PIAS4 PIAS2	5.33e-05	5	81	2	18579533
Pubmed	Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression.	RAG1 HCK	5.33e-05	5	81	2	28399411
Pubmed	TET2, ASXL1, IDH1, IDH2, and c-CBL genes in JAK2- and MPL-negative myeloproliferative neoplasms.	TET2 CBL	5.33e-05	5	81	2	21904853
Pubmed	CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element.	TET2 RAG1	5.33e-05	5	81	2	35304452
Pubmed	SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death.	PIAS3 PIAS2	5.33e-05	5	81	2	28622293
Pubmed	Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis.	TET2 RAG1	5.33e-05	5	81	2	26275994
Pubmed	BCL11A is a SUMOylated protein and recruits SUMO-conjugation enzymes in its nuclear body.	PIAS4 PIAS3	5.33e-05	5	81	2	18681895
Pubmed	SUMO Modification Reverses Inhibitory Effects of Smad Nuclear Interacting Protein-1 in TGF-β Responses.	PIAS3 PIAS2	5.33e-05	5	81	2	27703003
Pubmed	Pias1 interaction and sumoylation of metabotropic glutamate receptor 8.	GRM4 PIAS2	7.99e-05	6	81	2	16144832
Pubmed	Sumoylation modulates transcriptional activity of MITF in a promoter-specific manner.	PIAS3 PIAS2	7.99e-05	6	81	2	16029420
Pubmed	CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia.	TET2 CBL	7.99e-05	6	81	2	21346257
Pubmed	Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome.	TET2 BCOR	7.99e-05	6	81	2	27694924
Pubmed	Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation.	PIAS4 PIAS2	7.99e-05	6	81	2	15208321
Pubmed	A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription.	PIAS4 PIAS3	7.99e-05	6	81	2	20159969
Pubmed	Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.	CBL HCK	7.99e-05	6	81	2	9890970
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TET2 ALS2 BCOR SFMBT2	9.39e-05	101	81	4	10997877
Pubmed	Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor.	CBL HCK	1.12e-04	7	81	2	11994282
Pubmed	Integrated genetic approaches identify the molecular mechanisms of Sox4 in early B-cell development: intricate roles for RAG1/2 and CK1ε.	SOX4 RAG1	1.12e-04	7	81	2	24786772
Pubmed	Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.	RAG1 MAP3K7	1.12e-04	7	81	2	22080947
Pubmed	Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3.	SLC22A14 OXSR1	1.12e-04	7	81	2	10231028
Pubmed	SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function.	PIAS4 PIAS3	1.12e-04	7	81	2	31125786
Pubmed	Phospho-regulated SUMO interaction modules connect the SUMO system to CK2 signaling.	PIAS3 PIAS2	1.12e-04	7	81	2	19217413
Pubmed	Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice.	GRIN2B WDFY3	1.12e-04	7	81	2	36897941
Pubmed	Critical role of WNK1 in MYC-dependent early mouse thymocyte development.	RAG1 OXSR1	1.49e-04	8	81	2	33051000
Interaction	FAM90A26 interactions	FAM90A26 FAM90A1	1.09e-05	2	67	2	int:FAM90A26
Interaction	STAT3 interactions	PIAS3 WDFY3 CBL MAP3K7 ALK HCK TRIM59 LEPR ZNF829	1.61e-05	446	67	9	int:STAT3
Cytoband	8p23.1	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A2P FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16	4.17e-15	154	81	11	8p23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A2P CSMD1 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16	1.20e-14	234	81	12	chr8p23
Cytoband	18q21.1	SETBP1 PIAS2	2.07e-03	38	81	2	18q21.1
GeneFamily	Zinc fingers MIZ-type	PIAS4 PIAS3 PIAS2	7.34e-07	7	51	3	85
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SOX4 TET2 GRIN2B CSMD1 ITPRID1 HCK	6.16e-07	191	71	6	54f07e4de61735051498846afb44b1798bed8144
ToppCell	Adult-Immune-enucleated_erythrocyte\|Adult / Lineage, Cell type, age group and donor	PLAC1 SLC22A14 CPO DEPDC1B TRIM59	4.93e-06	155	71	5	e2d07ee4348d2c1d3552a8d0337ea42777c31f9c
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CECR2 MUC5B GRIN2B TECTA USH2A	5.75e-06	160	71	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CECR2 MUC5B GRIN2B TECTA USH2A	5.75e-06	160	71	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TDRD5 GRIN2B TECTA USH2A SFMBT2	6.11e-06	162	71	5	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TET2 GRIN2B CSMD1 ITPRID1 HCK	7.30e-06	168	71	5	8072d0496b7b730c4601009eaa69ec5366d26d73
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SOX4 PSAP GRIN2B CSMD1 USH2A	1.19e-05	186	71	5	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	facs-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX4 TDRD5 RAG1 PSAP CBL	1.43e-05	193	71	5	a6a864644e1b80b7417ea0a27281e79068a3fd3d
ToppCell	Children_(3_yrs)-Immune\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PSAP PIK3CD CBL HCK SFMBT2	1.58e-05	197	71	5	f18807124b91310fcd84238484a80ecdba684679
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	P2RX7 OSBPL11 CBL HCK SFMBT2	1.61e-05	198	71	5	e125eb8aa57c172e5518874da1bd25998292f5e2
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	P2RX7 OSBPL11 CBL HCK SFMBT2	1.61e-05	198	71	5	0baeb8e2c199ff10bb5c829c523546af3c9227c1
ToppCell	Immune\|World / Lineage, Cell type, age group and donor	PSAP PIK3CD CBL HCK SFMBT2	1.61e-05	198	71	5	65681b54d13c6997bd90a1c2a12314a80e964fe3
ToppCell	Macroglial-Polydendrocytes-PDGFRA-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	SOX4 USP43 GRIN2B CSMD1 MMP16	1.69e-05	200	71	5	f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCell	Macroglial-Polydendrocytes-PDGFRA--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	SOX4 USP43 GRIN2B CSMD1 MMP16	1.69e-05	200	71	5	cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCell	Macroglial-Polydendrocytes-PDGFRA\|Macroglial / cells hierarchy compared to all cells using T-Statistic	SOX4 USP43 GRIN2B CSMD1 MMP16	1.69e-05	200	71	5	c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCell	Macroglial-Polydendrocytes-PDGFRA---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	SOX4 USP43 GRIN2B CSMD1 MMP16	1.69e-05	200	71	5	4fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCell	Macroglial-Polydendrocytes-PDGFRA----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	SOX4 USP43 GRIN2B CSMD1 MMP16	1.69e-05	200	71	5	310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCell	Macroglial-Polydendrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	SOX4 USP43 GRIN2B CSMD1 MMP16	1.69e-05	200	71	5	961858738ce35db8760c8c2e136f8369bc444ccf
ToppCell	Adult-Immune-enucleated_erythrocyte-D175\|Adult / Lineage, Cell type, age group and donor	SLC22A14 CPO DEPDC1B TRIM59	1.02e-04	152	71	4	530d5427d8617dcb223d807b73abee0ef89285f3
ToppCell	facs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	USP43 CSMD1 LEPR SFMBT2	1.16e-04	157	71	4	1f21d78a467fe22c5ab75d0917b840c1ac93f32c
ToppCell	CV-Healthy-3\|CV / Virus stimulation, Condition and Cluster	RNF14 TNFRSF10A CBL PIAS2	1.27e-04	161	71	4	fd4a79385ea967b9900dc76a3add813b894a3a28
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-Tuft-related-Tuft\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GRIN2B CSMD1 ITPRID1 HCK	1.53e-04	169	71	4	05e12524d68d409fed386ffad233305683b4575b
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SOX4 LRRC4 MAPK8IP3 MORN3	1.60e-04	171	71	4	1854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCell	normal_Lung-T/NK_cells-CD8+/CD4+_Mixed_Th\|T/NK_cells / Location, Cell class and cell subclass	P2RX7 HCK TRIM59 MAPK8IP3	1.64e-04	172	71	4	0657c736f3c52d25cf7f652eac005ddcde9232ef
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CECR2 USP43 ABCA10 DEPDC1B	1.68e-04	173	71	4	4bc6d93716f093b460c8b047199db8cab5fea720
ToppCell	CV-Mild-7\|Mild / Virus stimulation, Condition and Cluster	TET2 TMED8 EPDR1 PIAS2	1.68e-04	173	71	4	c9bbca9313a0fdf146c8c995624b94b937e818d8
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Differentiating_glia\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	P2RX7 GRIN2B EPDR1 TECTA	1.72e-04	174	71	4	412ccc099028a372b9d953363984c2da54b2187f
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|normal_Lymph_Node / Location, Cell class and cell subclass	SOX4 SETBP1 OSBPL11 PFKFB2	1.79e-04	176	71	4	476794ef75ce5ab732d78cfeb4944e2f841e3e92
ToppCell	Control-Myeloid-pDC\|Myeloid / Disease state, Lineage and Cell class	SOX4 SETBP1 PFKFB2 EPDR1	1.83e-04	177	71	4	e82115bfc32c7b689460fbc5caeb983c1aabe30f
ToppCell	Club_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	SOX4 MUC5B ITPRID1 LRRC4	1.87e-04	178	71	4	be64d4be23fb96a4cdd7980c58880fdfe817747f
ToppCell	3'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PSAP GRIN2B ITPRID1 HCK	1.91e-04	179	71	4	906555ce2ca264a0215b120c7ff7c9b411de6a34
ToppCell	Ciliated_cells-A-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	MUC5B DLEC1 LRRC4 MORN3	1.95e-04	180	71	4	d9be152773fe9f2160edad9246fa03c03afeafd6
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CECR2 USP43 ABCA10 DEPDC1B	1.99e-04	181	71	4	e0abf2707d9e0aa942c657eef7d2cbcd02f060dd
ToppCell	B_cell_maturation-immature_B_cell\|World / Lineage and Cell class	SOX4 RAG1 CECR2 HCK	2.04e-04	182	71	4	2c7c51ebc4125d8a33454ffee0b143579ce5e451
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX4 RAG1 CECR2 ITPRID1	2.08e-04	183	71	4	bc24145855bf4d027a8058bf92bc796c10f241bb
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX4 RAG1 CECR2 ITPRID1	2.08e-04	183	71	4	4c325ee6da070513097a11445ec95b0415ffd8a2
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUC5B GRIN2B CSMD1 USH2A	2.12e-04	184	71	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUC5B GRIN2B CSMD1 USH2A	2.12e-04	184	71	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUC5B GRIN2B CSMD1 USH2A	2.12e-04	184	71	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-Tuft-related-Tuft\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GRIN2B CSMD1 ITPRID1 HCK	2.17e-04	185	71	4	686ed7550c6acd18e71e0076936ec5b07389adbd
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RAG1 GRIN2B TECTA GRM4	2.21e-04	186	71	4	bdc87e4631a8ea73e262e541aa84a28f24c94b00
ToppCell	Adult-Endothelial-endothelial_cell_of_artery\|Adult / Lineage, Cell type, age group and donor	SETBP1 CSMD1 MMP16 LEPR	2.21e-04	186	71	4	2d1c4ea2e401db89971582ee54618a8b0c81b8ac
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l30\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GGNBP2 EPDR1 CSMD1 LRRC4	2.26e-04	187	71	4	6f7f293c9cf35261e0e3614e46ec1fb00a701b63
ToppCell	Control-Fibroblasts-Other_FB\|Control / group, cell type (main and fine annotations)	SETBP1 MMP16 ABCA10 LEPR	2.26e-04	187	71	4	bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CECR2 USP43 ABCA10 DEPDC1B	2.35e-04	189	71	4	977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination__)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX4 TDRD5 RAG1 PSAP	2.40e-04	190	71	4	2f5460fa028dfe6b80dd024063a4513dc532a94d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	P2RX7 PIK3CD HCK SFMBT2	2.40e-04	190	71	4	788ff9d8888d2dd25b7e1d7e0e5d57751ce86f19
ToppCell	LV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	SYTL4 ERI2 VEGFD ABCA10	2.40e-04	190	71	4	12992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CECR2 USP43 ABCA10 DEPDC1B	2.40e-04	190	71	4	e252e925600e6457fa6e362a55217f4cffa75cdb
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	P2RX7 PIK3CD HCK SFMBT2	2.45e-04	191	71	4	baa70781633a3fe5bf987f9d8dff3884f5167e7f
ToppCell	COVID-19-lung-Macrophage_PPARGhi_CD5Lhi\|lung / Disease (COVID-19 only), tissue and cell type	PSAP P2RX7 HCK SFMBT2	2.45e-04	191	71	4	dab953682b8c9ed680a799161f837f792a7e4f33
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-immature_T_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX4 TDRD5 RAG1 PSAP	2.50e-04	192	71	4	7ad0aa18d6debe0dc26dbb0d33be656b734b5e73
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-immature_T_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX4 TDRD5 RAG1 PSAP	2.50e-04	192	71	4	cd9bccbef1ef6bb39c310039884e2acb81e63c7c
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TNFRSF10A MMP16 LEPR SFMBT2	2.50e-04	192	71	4	0aeb5351275c0a91151ea2d52b2cdde172da6731
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-DN_to_DP_transition_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination__)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX4 TDRD5 RAG1 PSAP	2.50e-04	192	71	4	7299a0bbba8998cff4c6fd136f7e2d644ee5bd45
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D122\|Adult / Lineage, Cell type, age group and donor	PSAP P2RX7 OSBPL11 HCK	2.55e-04	193	71	4	cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	P2RX7 PIK3CD HCK SFMBT2	2.60e-04	194	71	4	96f16bcd393a0d3f8df479b172b5360ae5a1e663
ToppCell	facs-Thymus-nan-3m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX4 TDRD5 RAG1 CBL	2.60e-04	194	71	4	f1661f9f2439fca5c1012c693b0744c4e3b90a9b
ToppCell	facs-Thymus-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX4 TDRD5 RAG1 CBL	2.60e-04	194	71	4	cda1b197efb199330ea7ab25a7cee22cae22589d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	P2RX7 PIK3CD HCK SFMBT2	2.60e-04	194	71	4	1dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCell	facs-Thymus-nan-3m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX4 TDRD5 RAG1 CBL	2.60e-04	194	71	4	66c056232ac216780acf4cc8ea325bd8ed1909c9
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PSAP P2RX7 OXSR1 HCK	2.60e-04	194	71	4	dfe0ece81922bfd7c6673726d3ea2365cbdb5513
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	P2RX7 PIK3CD HCK SFMBT2	2.65e-04	195	71	4	2d485373bfd9bb4bb9236bf0b31d03e132c8018f
ToppCell	COVID-19-lung-Macrophage_CD163hi_MERTKhi\|lung / Disease (COVID-19 only), tissue and cell type	TET2 PSAP P2RX7 HCK	2.65e-04	195	71	4	148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TET2 PSAP P2RX7 HCK	2.65e-04	195	71	4	62dc745e1aa3e2e58afa16c7bb2cf9b03d4e8105
ToppCell	facs-Thymus-nan-3m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX4 TDRD5 RAG1 CBL	2.65e-04	195	71	4	79114b3c78cc15c413bb58f0673e7215b784a9b6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	P2RX7 PIK3CD HCK SFMBT2	2.65e-04	195	71	4	09df40ff9b493170861b3f6e57a942a834655b5c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	P2RX7 PIK3CD HCK SFMBT2	2.65e-04	195	71	4	34a9462f4e843f3065cc58c17ad71c1b5b836ae1
ToppCell	COVID-19-Myeloid-Monocytes\|COVID-19 / group, cell type (main and fine annotations)	TET2 PSAP CBL HCK	2.70e-04	196	71	4	04d710267658ea5601ae2cfb4ed5acb8a29bd8a1
ToppCell	Children_(3_yrs)-Immune-monocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TET2 PIK3CD CBL HCK	2.70e-04	196	71	4	cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TET2 PSAP HCK SFMBT2	2.75e-04	197	71	4	8af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCell	COVID-19-lung-Macrophage_VCANhi_FCN1hi\|lung / Disease (COVID-19 only), tissue and cell type	PSAP P2RX7 PIK3CD HCK	2.75e-04	197	71	4	a0f8a992282a6d64890f5574c7c9741fcb38dadd
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	P2RX7 PIK3CD HCK SFMBT2	2.75e-04	197	71	4	d95565652ca318a2298d6918d54ba6367e9560f4
ToppCell	COVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi\|lung / Disease (COVID-19 only), tissue and cell type	PSAP P2RX7 HCK SFMBT2	2.75e-04	197	71	4	3896729740d151f0eb845f1961c7b969bfbdd28d
ToppCell	Fetal_29-31_weeks-Immune-monocyte-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PSAP P2RX7 PIK3CD HCK	2.75e-04	197	71	4	8b9a88fb671d5c2b25d291c851e2b8a478f2610c
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TET2 PSAP HCK SFMBT2	2.75e-04	197	71	4	c6e977adb1248957d31300312310e08238b64236
ToppCell	COVID-19-lung-Macrophage_VCANhi_FCN1hi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PSAP P2RX7 PIK3CD HCK	2.81e-04	198	71	4	ea34096bee852a7e996f097fa279381afa8f86ff
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	P2RX7 PIK3CD HCK SFMBT2	2.81e-04	198	71	4	96883ad8e189a46ed5b7eaafc0543e53682d26ed
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PSAP PFKFB2 WDFY3 HCK	2.81e-04	198	71	4	df546a9afc0e15398f33c1b511c7281771f9aea0
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SETBP1 GRIN2B CSMD1 MMP16	2.81e-04	198	71	4	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Adult-Immune\|Adult / Lineage, Cell type, age group and donor	PSAP PIK3CD HCK SFMBT2	2.81e-04	198	71	4	9bfd7b88aa646eaf5eddb15cf985c7ca910cb35e
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PSAP P2RX7 HCK SFMBT2	2.81e-04	198	71	4	6a4161680b46b2c12353a693c403b5a4bb3da03f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	P2RX7 PIK3CD HCK SFMBT2	2.86e-04	199	71	4	04adf46975aa4194ea40c7480f8a517def5d929c
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Macrophage_other-Macro_interstitial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PSAP P2RX7 HCK SFMBT2	2.86e-04	199	71	4	4b6d49b96bfcd6604b082bab620ae03276520885
ToppCell	Parenchymal-NucSeq-Immune_Myeloid\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PSAP P2RX7 HCK SFMBT2	2.86e-04	199	71	4	7ee2805fd9143eba11bf6832267b62189683608b
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD16\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PSAP PIK3CD CBL HCK	2.86e-04	199	71	4	ac866ae110967c5867ff4601939b79861d43df54
ToppCell	mild-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 PSAP WDFY3 HCK	2.92e-04	200	71	4	934c2efc780318c66d667ca75be0de350361d351
ToppCell	Children_(3_yrs)-Immune-monocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TET2 PIK3CD CBL HCK	2.92e-04	200	71	4	881ab995c90d75fd987d6e8f1f926a4bfcc4235f
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Monocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PSAP P2RX7 CBL HCK	2.92e-04	200	71	4	8872d5fa101d413fb43b4231d476878678543035
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD16\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PSAP P2RX7 CBL HCK	2.92e-04	200	71	4	fc061de0db2e8b5ca47f5e2a1e861018e7f1b582
Disease	hematologic cancer (implicated_via_orthology)	PIAS4 PIAS3 PIAS2	3.01e-06	13	66	3	DOID:2531 (implicated_via_orthology)
Disease	Colorectal Carcinoma	TET2 P2RX7 SACS SETBP1 CPO ERI2 ITPRID1 LRRC4 ABCA10	2.56e-05	702	66	9	C0009402
Disease	Myelomonocytic leukemia	SETBP1 CBL	4.91e-05	5	66	2	C0027019
Disease	monoclonal gammopathy	SETBP1 CSMD1 SFMBT2	2.31e-04	53	66	3	EFO_0000203
Disease	MYELODYSPLASTIC SYNDROME	TET2 SETBP1 CBL	4.62e-04	67	66	3	C3463824
Disease	Leukemia, Myelocytic, Acute	TET2 SETBP1 BCOR CBL	6.20e-04	173	66	4	C0023467
Disease	urinary bladder cancer (is_implicated_in)	SOX4 MUC5B TNFRSF10A	6.69e-04	76	66	3	DOID:11054 (is_implicated_in)
Disease	Myeloid Leukemia	SETBP1 ATG2B	7.37e-04	18	66	2	C0023470
Disease	Leukemia, Monocytic, Chronic	SETBP1 ATG2B	7.37e-04	18	66	2	C0023466
Disease	Juvenile Myelomonocytic Leukemia	SETBP1 CBL	8.22e-04	19	66	2	C0349639
Disease	event free survival time, urinary bladder cancer	GRIN2B SFMBT2	8.22e-04	19	66	2	EFO_0000482, MONDO_0001187
Disease	acute myeloid leukemia (is_implicated_in)	TET2 DLEC1 CBL	8.95e-04	84	66	3	DOID:9119 (is_implicated_in)
Disease	Anophthalmia-microphthalmia syndrome	BCOR VSX2	1.01e-03	21	66	2	cv:C5680330
Disease	triacylglycerol 58:9 measurement	CPO CSMD1	1.11e-03	22	66	2	EFO_0010443
Disease	Neurodevelopmental Disorders	SETBP1 GRIN2B WDFY3	1.20e-03	93	66	3	C1535926
Disease	Epilepsy, Benign Psychomotor, Childhood	P2RX7 GRM4	1.21e-03	23	66	2	C0393672
Disease	Epilepsy, Lateral Temporal	P2RX7 GRM4	1.21e-03	23	66	2	C0393682
Disease	Uncinate Epilepsy	P2RX7 GRM4	1.21e-03	23	66	2	C0014558
Disease	Epilepsy, Temporal Lobe	P2RX7 GRM4	1.21e-03	23	66	2	C0014556
Disease	sensory peripheral neuropathy, remission	DLEC1 CSMD1	1.21e-03	23	66	2	EFO_0009785, MONDO_0002321
Disease	peptide measurement	DLEC1 CSMD1 MMP16	1.89e-03	109	66	3	EFO_0010520
Disease	gas trapping measurement	DLEC1 CSMD1	1.92e-03	29	66	2	EFO_0007628
Disease	opioid dependence	DLEC1 GRIN2B CSMD1 SFMBT2	1.98e-03	237	66	4	EFO_0005611
Disease	pneumonia, COVID-19	PPP2R5E GRIN2B CSMD1	2.10e-03	113	66	3	EFO_0003106, MONDO_0100096

Protein segments in the cluster

Peptide	Gene	Start	Entry
KEMPQKDWCFSTPKD	TDRD5	776	Q8NAT2
PVIRGLMKFWPKTCS	PPP2R5E	301	Q16537
ELTKKLMPNCKWVSS	BOP1	611	Q14137
PWKSGKMTPPLCKCG	ERI2	586	A8K979
TKTPNLRMSEKKCSW	PFKFB2	16	O60825
KQCSKMTLTQPWDPL	EPDR1	111	Q9UM22
TCKADMKWTGKSPVC	CSMD1	3316	Q96PZ7
MKWTGKSPVCKSKGV	CSMD1	3321	Q96PZ7
CPQENSLWPKLTMKE	ABCA10	1286	Q8WWZ4
WKTFPGKMTDSLRKP	ALS2	896	Q96Q42
PGERKKTVKGMPCCW	GRM4	526	Q14833
SKELPHWVLSAMKCL	DEPDC1B	236	Q8WUY9
HCADKSLPWKMGVSP	BCOR	281	Q6W2J9
SQPSGNPKKIIWMDC	CPO	91	Q8IVL8
CKAMKGKNPWPSDSS	CECR2	1036	Q9BXF3
MPWPFSESIKKRACR	ATG2B	1	Q96BY7
MAKTWLVPDSRKDGC	MUC5B	5246	Q9HC84
KMKPVWRSSCPAKEC	RAG1	891	P15918
KPDPKTWKANFRCAM	IRF2	71	P14316
STRCPMKCWKAALVP	FAM90A7	56	A6NKC0
KVRKTFVGTPCWMAP	OXSR1	181	O95747
STRCPMKCWKAALVP	FAM90A23	56	A8MXZ1
RPLVEKDPTMKLWCA	MAPK8IP3	696	Q9UPT6
SLDTHKPKPLGGCWM	GGNBP2	166	Q9H3C7
GLLSKQWPCSSMPAK	ITPRID1	331	Q6ZRS4
STRCPMKCWKAALVP	FAM90A1	56	Q86YD7
CEPDMKLVWPSAKLL	MMS19	361	Q96T76
STRCPMKCWKAALVP	FAM90A22	56	A8MWA6
STRCPMKCWKAALVP	FAM90A14	56	P0C7W9
SMLKTPKLPIWLCNI	MINDY4B	356	A8MYZ0
PKPIESLMTRCWSKD	MAP3K7	256	O43318
ELKCRTPPMSSVKWL	LRRC4	371	Q9HBW1
TLLWKPLMKNDSLCS	LEPR	661	P48357
MSCVPWKGDKAKSES	JOSD1	1	Q15040
STRCPMKCWKAALVP	FAM90A17	56	P0DV74
STRCPMKCWKAALVP	FAM90A16	56	P0DV73
STRCPMKCWKAALVP	FAM90A19	56	P0DV76
STRCPMKCWKAALVP	FAM90A8	56	A6NJQ4
SDRGCKKGWMDPQSK	P2RX7	131	Q99572
KLSVPCMSSKPQKPW	HCK	236	P08631
HPPGTVDKKMVEKCW	CBL	46	P22681
STRCPMKCWKAALVP	FAM90A20P	56	A6NIJ5
CIMPKTSWPPLSFKA	DLEC1	511	Q9Y238
STRCPMKCWKAALVP	FAM90A5P	56	A8MXJ8
LKWPRCPATELKSMT	SLC22A14	466	Q9Y267
IPMKTAEWLKVPCLS	SACS	1426	Q9NZJ4
STRCPMKCWKAALVP	FAM90A24P	56	P0C7X0
MPVSKCPKKSESLWK	MORN3	1	Q6PF18
PIIGETFHCSWKMPK	OSBPL11	451	Q9BXB4
MNEKKPTWICPVCDK	PIAS2	376	O75928
DGSWCPMRPKKEAMK	PIAS2	421	O75928
SPWLTKPCSMRVASK	PLAC1	121	Q9HBJ0
SGLFPEWKKMSAPKS	SYTL4	221	Q96C24
KALGSACIEIKWMPP	USH2A	3876	O75445
WCKTPSGHIKRPMNA	SOX4	51	Q06945
STRCPMKCWKAALVP	FAM90A12P	56	A8MX19
STRCPMKCWKAALVP	FAM90A9	56	A6NNJ1
STRCPMKCWKAALVP	FAM90A13P	56	P0C7W8
STRCPMKCWKAALVP	FAM90A26	56	D6RGX4
MKCWKAALVPPTLGK	FAM90A26	61	D6RGX4
PASPKCAAWLKVKTS	KIAA0753	566	Q2KHM9
ALWPMLQKKLKACTP	PIGC	211	Q92535
STRCPMKCWKAALVP	FAM90A15P	56	P0C7V4
APIKSSPCELRMSWL	ALK	541	Q9UM73
EDGSWCPMKPKKEAS	PIAS3	401	Q9Y6X2
WKTNGMQKRPLAPSC	TECTA	1651	O75443
MESKEWLEKNSKSCP	RNF14	391	Q9UBS8
KTMPLRWSFGSKEKP	USP43	811	Q70EL4
CGKVFKWPSSLPIHM	ZNF555	541	Q8NEP9
MERSLSCPPKNGWEK	WDFY3	661	Q8IZQ1
NTIDWMKKPRCGVPD	MMP16	91	P51512
AAAGMVWKPKSCEPI	DNTTIP1	181	Q9H147
PSDKMKWCLRVNPKG	SPOPL	61	Q6IQ16
STRCPMKCWKAALVP	FAM90A2P	56	Q658T7
MKCWKAALVPPTLGK	FAM90A2P	61	Q658T7
PLKMASEWKCTLEKS	SFMBT2	261	Q5VUG0
SKKADCPIAWANLML	PIK3CD	411	O00329
WLPKPNMSASCKEIV	PSAP	96	P07602
CPRGMVKVKDCTPWS	TNFRSF10A	211	O00220
PQKTMSEEKPWECKI	ZNF829	146	Q3KNS6
MNEKKPTWMCPVCDK	PIAS4	356	Q8N2W9
VWSPPSRKKPMLSAC	nan	21	A8MUI8
KNCLPWKIPASMKEV	TEX26	121	Q8N6G2
SHSKKLCPIDMLWDS	VEGFD	216	O43915
RWTCSKPKPSTMLRE	SETBP1	531	Q9Y6X0
ACMHTAPPENKTWKK	TET2	991	Q6N021
KISPKRMSCSWPGKD	TRIM59	306	Q8IWR1
EFRKSPSSTWIMKPC	TTLL1	126	O95922
LMAPPCIWTFAKVKE	TMED8	156	Q6PL24
DSCAPWLLGMHKKSL	VSX2	246	P58304
STRCPMKCWKAALVP	FAM90A18	56	P0DV75
MKPRAECCSPKFWLV	GRIN2B	1	Q13224