Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessprotein O-linked glycosylation via serine

POGLUT3 GALNT3

8.53e-0510292GO:0018242
GeneOntologyBiologicalProcesssequestering of extracellular ligand from receptor

CD46 LTBP1

1.04e-0411292GO:0035581
GeneOntologyBiologicalProcessextracellular regulation of signal transduction

CD46 LTBP1

1.47e-0413292GO:1900115
GeneOntologyBiologicalProcessextracellular negative regulation of signal transduction

CD46 LTBP1

1.47e-0413292GO:1900116
GeneOntologyBiologicalProcessmotor neuron migration

CELSR1 CELSR3

1.98e-0415292GO:0097475
DomainEGF_LAM_2

NTN4 CELSR1 CELSR3

1.47e-0530303PS50027
DomainEGF_LAM_1

NTN4 CELSR1 CELSR3

1.47e-0530303PS01248
DomainLaminin_EGF

NTN4 CELSR1 CELSR3

2.36e-0535303PF00053
DomainEGF_Lam

NTN4 CELSR1 CELSR3

2.36e-0535303SM00180
DomainLaminin_EGF

NTN4 CELSR1 CELSR3

3.04e-0538303IPR002049
DomainEGF_1

NTN4 CELSR1 LTBP1 CELSR3 ADAM15

4.92e-05255305PS00022
DomainClathrin

WDR19 TGFBRAP1

5.21e-057302PF00637
DomainEGF-like_CS

NTN4 CELSR1 LTBP1 CELSR3 ADAM15

5.49e-05261305IPR013032
DomainClathrin_H-chain/VPS_repeat

WDR19 TGFBRAP1

6.94e-058302IPR000547
DomainGAIN_dom_N

CELSR1 CELSR3

1.36e-0411302IPR032471
DomainGAIN

CELSR1 CELSR3

1.36e-0411302PF16489
DomainEGF_3

CELSR1 LTBP1 CELSR3 ADAM15

5.18e-04235304PS50026
DomainEGF

CELSR1 LTBP1 CELSR3 ADAM15

5.18e-04235304SM00181
DomainASX_HYDROXYL

CELSR1 LTBP1 CELSR3

5.44e-04100303PS00010
DomainEGF-like_dom

CELSR1 LTBP1 CELSR3 ADAM15

6.43e-04249304IPR000742
DomainEGF-type_Asp/Asn_hydroxyl_site

CELSR1 LTBP1 CELSR3

6.45e-04106303IPR000152
DomainHormR

CELSR1 CELSR3

7.31e-0425302SM00008
DomainEGF_2

CELSR1 LTBP1 CELSR3 ADAM15

8.12e-04265304PS01186
DomainHRM

CELSR1 CELSR3

9.19e-0428302PF02793
DomainEGF_CA

CELSR1 LTBP1 CELSR3

9.71e-04122303SM00179
DomainEGF-like_Ca-bd_dom

CELSR1 LTBP1 CELSR3

1.02e-03124303IPR001881
DomainEGF

CELSR1 LTBP1 CELSR3

1.07e-03126303PF00008
DomainGPS

CELSR1 CELSR3

1.36e-0334302SM00303
DomainGPS

CELSR1 CELSR3

1.44e-0335302PF01825
DomainGPS

CELSR1 CELSR3

1.52e-0336302PS50221
DomainGPS

CELSR1 CELSR3

1.60e-0337302IPR000203
DomainLAM_G_DOMAIN

CELSR1 CELSR3

1.69e-0338302PS50025
DomainPeptidase_M12B_N

ADAMTS20 ADAM15

1.78e-0339302IPR002870
DomainPep_M12B_propep

ADAMTS20 ADAM15

1.78e-0339302PF01562
DomainDISINTEGRIN_1

ADAMTS20 ADAM15

1.87e-0340302PS00427
DomainG_PROTEIN_RECEP_F2_1

CELSR1 CELSR3

1.87e-0340302PS00649
DomainLaminin_G_2

CELSR1 CELSR3

1.87e-0340302PF02210
DomainADAM_MEPRO

ADAMTS20 ADAM15

1.87e-0340302PS50215
DomainDISINTEGRIN_2

ADAMTS20 ADAM15

1.87e-0340302PS50214
DomainG_PROTEIN_RECEP_F2_3

CELSR1 CELSR3

1.87e-0340302PS50227
DomainGPCR_2_extracellular_dom

CELSR1 CELSR3

1.87e-0340302IPR001879
DomainReprolysin

ADAMTS20 ADAM15

1.87e-0340302PF01421
DomainPeptidase_M12B

ADAMTS20 ADAM15

1.87e-0340302IPR001590
DomainGrowth_fac_rcpt_

NTN4 CELSR1 LTBP1

1.97e-03156303IPR009030
DomainDisintegrin_dom

ADAMTS20 ADAM15

1.97e-0341302IPR001762
DomainLamG

CELSR1 CELSR3

2.26e-0344302SM00282
DomainG_PROTEIN_RECEP_F2_2

CELSR1 CELSR3

2.91e-0350302PS00650
Domain7tm_2

CELSR1 CELSR3

2.91e-0350302PF00002
DomainLaminin_G

CELSR1 CELSR3

3.90e-0358302IPR001791
DomainGPCR_2-like

CELSR1 CELSR3

4.17e-0360302IPR017981
DomainGPCR_2_secretin-like

CELSR1 CELSR3

4.17e-0360302IPR000832
DomainG_PROTEIN_RECEP_F2_4

CELSR1 CELSR3

4.30e-0361302PS50261
DomainMetalloPept_cat_dom

ADAMTS20 ADAM15

7.47e-0381302IPR024079
Domain-

ADAMTS20 ADAM15

7.47e-03813023.40.390.10
DomainGalactose-bd-like

NTN4 HECTD3

9.95e-0394302IPR008979
Domain-

CELSR1 CELSR3

1.02e-02953022.60.120.200
DomainZINC_PROTEASE

ADAMTS20 ADAM15

1.08e-0298302PS00142
Pubmed

The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development.

CELSR1 CELSR3

2.16e-06330211677057
Pubmed

Developmental expression profiles of Celsr (Flamingo) genes in the mouse.

CELSR1 CELSR3

4.31e-06430211850187
Pubmed

The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.

CELSR1 CELSR3

4.31e-06430237224017
Pubmed

POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.

POGLUT3 LTBP1

7.18e-06530234411563
Pubmed

Dystroglycan is a scaffold for extracellular axon guidance decisions.

CELSR1 CELSR3

1.08e-05630230758284
Pubmed

Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues.

CELSR1 CELSR3

1.51e-05730217937400
Pubmed

Computational modelling of Smad-mediated negative feedback and crosstalk in the TGF-β superfamily network.

LTBP1 SMAD9

2.01e-05830223804438
Pubmed

Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.

POGLUT3 LTBP1

2.58e-05930238844137
Pubmed

A dual role for planar cell polarity genes in ciliated cells.

CELSR1 CELSR3

3.94e-051130225024228
Pubmed

Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development.

CELSR1 CELSR3

4.72e-051230211891983
Pubmed

Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice.

CELSR1 CELSR3

4.72e-051230220631168
Pubmed

Cytoneme signaling provides essential contributions to mammalian tissue patterning.

DISP1 SMAD9

6.50e-051430238171360
Pubmed

A non-autonomous function of the core PCP protein VANGL2 directs peripheral axon turning in the developing cochlea.

CELSR1 CELSR3

6.50e-051430229784671
Pubmed

Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex.

CELSR1 CELSR3

6.50e-051430239225402
Pubmed

Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.

CELSR1 CELSR3

7.50e-051530220473291
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

WDR19 CELSR3 SBF1 ZNF608 INTS2

8.31e-0552930514621295
Pubmed

ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.

ADAMTS20 SMAD9

1.35e-042030219922873
Pubmed

Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.

TNFRSF11A GALNT3

1.80e-042330224945404
Pubmed

Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis.

ADAMTS20 DISP1

2.13e-042530229475039
Pubmed

Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos.

CELSR1 CELSR3

2.31e-042630237228654
Pubmed

Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.

LTBP1 SMAD9

3.29e-043130225762570
Pubmed

Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis.

CELSR1 CELSR3

3.51e-043230223177622
Pubmed

Splicing Regulator p54nrb /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma.

CD46 ADAM15

3.51e-043230231815296
Pubmed

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.

CELSR1 CELSR3

3.74e-043330225713288
Pubmed

Galnt1 is required for normal heart valve development and cardiac function.

ADAMTS20 GALNT3

4.45e-043630225615642
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

CD46 CELSR1 LTBP1 GALNT3 CELSR3 ADAM15

4.88e-04120130635696571
Pubmed

Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.

HECTD3 PREP SMAD9

5.24e-0418330331932471
Pubmed

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

KCNK5 ADAMTS20 DHX57 CD46 TGFBRAP1

6.08e-0481430523251661
Pubmed

Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.

CELSR1 CELSR3

7.59e-044730233141892
CytobandEnsembl 112 genes in cytogenetic band chr22q13

CELSR1 SBF1 L3MBTL2

1.29e-03330303chr22q13
CytobandEnsembl 112 genes in cytogenetic band chr2p22

DHX57 LTBP1

2.12e-03104302chr2p22
GeneFamilyAdhesion G protein-coupled receptors, subfamily C|CELSR cadherins

CELSR1 CELSR3

4.64e-063232913
GeneFamilyAdhesion G protein-coupled receptors, subfamily C|CELSR cadherins

CELSR1 CELSR3

4.64e-0632321189
ToppCellP15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

WDR19 PRORP GALNT3 SMAD9

4.65e-061673045c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCell3'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NTN4 CELSR1 TNFRSF11A GALNT3

5.35e-0617330481c36b9fe02c59099f080b2db02f4eaf2783911f
ToppCell15-Trachea-Mesenchymal-Mesenchyme_RSPO2+|Trachea / Age, Tissue, Lineage and Cell class

POGLUT3 SEMA4A ZNF608 SMAD9

5.47e-06174304fa0681e91724b9a51ee28b214ea5aa14e62ba1a3
ToppCell10x5'-lymph-node_spleen-Lymphocytic_B-GC_B_(II)|lymph-node_spleen / Manually curated celltypes from each tissue

ADAMTS20 SEMA4A ZNF608 STAG3

5.73e-061763045788dd5b23ebb52f19d3b5bdbcfe25dee349cf77
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

WDR19 NTN4 CD46 STAG3

6.12e-06179304adf8b025032a03dbb58871a92025cd7efbeb22ff
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 CD46 DISP1 SMAD9

7.75e-06190304b855b8b7d3439023390ca44629c1a99f5d4c6801
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-13|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FAM131C ZNF608 STAG3

1.22e-04144303b2a9f3b5dd46d27689467f4a5fd717cd5827821f
ToppCellAdult-Mesenchymal-myofibroblast_cell-D175|Adult / Lineage, Cell type, age group and donor

LTBP1 TNFRSF11A STAG3

1.70e-04161303048b7dc00746987a24bf870d4d278c4183eb04a2
ToppCellfacs-Marrow-Granulocytes-24m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LTBP1 TNFRSF11A STAG3

1.73e-041623032787be283b7a705647058aeb9bc54006ce5ffe95
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

KCNK5 POGLUT3 SBF1

1.80e-04164303583dda853cee9491dbdcb228c23d8deadc20eb08
ToppCellfacs-Marrow-Granulocytes-24m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LTBP1 TNFRSF11A STAG3

2.00e-041703038d3c51364a332020810836e2055c60893c10d7f3
ToppCellE18.5-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NTN4 DISP1 SMAD9

2.07e-041723031bbf5ed7d13635f9a7e528060341e0652699bd7c
ToppCellfacs-Lung-nan-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNK5 CELSR1 SEMA4A

2.14e-041743031c073177c1753e3b91ef8fd9e95230a1d13c82f3
ToppCellfacs-Lung-nan-3m-Lymphocytic-CD8+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNK5 CELSR1 SEMA4A

2.14e-041743035491ad5c144baf2ef9b1c58eb720c872d14feb15
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

KCNK5 CD46 CELSR1

2.21e-041763033bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCellfacs-Marrow-Granulocytes-24m-Hematologic-MPP_Fraction_B|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LTBP1 TNFRSF11A STAG3

2.25e-041773034a697866ed542d3201714234cee03451adf1dcc9
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Paneth|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NTN4 TNFRSF11A GALNT3

2.25e-041773032af09028014f4ec3b7d2a4c286f1ae5e84a9f590
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 SEMA4A SMAD9

2.29e-04178303c20f050344a2e120e685e2a7fe36c6dfc1dc37b6
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

LTBP1 TNFRSF11A INTS2

2.29e-041783039d575902d3dbe33437c9d4200df093a741269803
ToppCellnormal_Lymph_Node-B_lymphocytes-GC_B_cells_in_the_LZ|normal_Lymph_Node / Location, Cell class and cell subclass

SEMA4A ZNF608 STAG3

2.29e-04178303d75057e7463558a0d3cebde3c30befbf4704dd9a
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NTN4 CELSR1 ZNF608

2.32e-04179303815b959ce8721c5ded70c0ca6e318dafc691746e
ToppCellFetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FAM131C LTBP1 SMAD9

2.40e-0418130325915e2500430a902db37d79a749ce2990b69810
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 CELSR1 SMAD9

2.48e-04183303738e94b50c4c08c727d4eed0708dda08aa6891b4
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 CELSR1 SMAD9

2.48e-0418330392fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Adult / Lineage, Cell type, age group and donor

KCNK5 NTN4 ZNF608

2.56e-04185303673f0c688ae6984bc8027df2da335787924f4137
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

NTN4 CELSR1 ZNF608

2.56e-04185303cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NTN4 CELSR1 ZNF608

2.60e-041863032ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 SEMA4A SMAD9

2.64e-041873039225caf66e06ebe57e90d677122acb6498607f36
ToppCell10x3'2.3-week_12-13-Mesenchymal_fibro-stroma-endosteal_fibroblast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FAM131C NTN4 DISP1

2.72e-04189303c392491aabe8a3e90974ab2ea123bbbe5200439d
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNK5 LTBP1 GALNT3

2.72e-0418930327e5d706f10a6221f314faf642eede15deab3165
ToppCelltumor_Lung-B_lymphocytes-GC_B_cells_in_the_LZ|B_lymphocytes / Location, Cell class and cell subclass

SEMA4A ZNF608 STAG3

2.77e-04190303bfb16efb23add53eebabc8e48f20c96994ec01da
ToppCell10x5'-GI_large-bowel-Lymphocytic_B-GC_B_(II)|GI_large-bowel / Manually curated celltypes from each tissue

SEMA4A ZNF608 STAG3

2.77e-04190303fee64bacbb330d04dc1dc63909838f2c605d9f1f
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS20 LTBP1 ZNF608

2.77e-041903032f54da2bee411f8868348a4c37034184b8f58a89
ToppCellfacs-Thymus-Flowthrough-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POGLUT3 LTBP1 MUSK

2.77e-04190303990ac07f4b0a22041daac7502f74fafd6d258cba
ToppCellfacs-Thymus-Flowthrough-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POGLUT3 LTBP1 MUSK

2.77e-04190303fc9bbe5e6e0ec3cfa47bf479d8b09a0fc53169cc
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CD46 DISP1 SMAD9

2.77e-04190303a5db902ad112a0c0a0a7f1a2e38718bb3bd11412
ToppCellfacs-Thymus-Flowthrough-24m-Mesenchymal|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POGLUT3 LTBP1 MUSK

2.77e-0419030339ecdf8815e235771132684dfc1aff1917e20965
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

NTN4 CELSR1 ZNF608

2.81e-04191303e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS20 NTN4 ZNF608

2.81e-041913039c0ee270209b02043393416ecc9a81ddedfbb8b6
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS20 NTN4 ZNF608

2.90e-04193303d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS20 NTN4 ZNF608

2.90e-041933038b77625bf3c87d39767fb391d1beaca4ab02342b
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS20 NTN4 ZNF608

2.90e-04193303010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS20 NTN4 ZNF608

2.90e-04193303e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 SEMA4A DISP1

2.90e-041933030f2167eef8203a5659c8c72e4e77646003d64797
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

KCNK5 LTBP1 DISP1

2.90e-041933032f203f6f0c2135acb046c9351a633c3b5b254a46
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS20 NTN4 ZNF608

2.94e-04194303e5990880961d2469759ce4b3b20ae93ace3ebd1f
ToppCellmoderate-Epithelial-FOXN4+|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

POGLUT3 GALNT3 ADAM15

2.94e-041943035dffa578149104dda33774361e9e77b227b5f1ce
ToppCellsevere-B_cell|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CELSR1 ZNF608 STAG3

2.99e-041953030fc3c605609c9e6bdea15d73c45def2188ae5fb1
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Macroglial-Glia_progenitor_cell|GW09 / Sample Type, Dataset, Time_group, and Cell type.

SEMA4A ADAM15 TGFBRAP1

3.03e-041963037be50b9156394dea44d7b8b476d4dd516abfafae
ToppCellControl_saline-Epithelial_alveolar-AT_2-Differentiating_AT2|Control_saline / Treatment groups by lineage, cell group, cell type

NTN4 CELSR1 GALNT3

3.08e-0419730344a59dfb889577b3160a5b13ada1276771a00241
ToppCellsaliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KCNK5 CELSR1 GALNT3

3.08e-04197303d6c9da7a3a6d2bcb13e2fc6605c8a59e7fb121c5
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

NTN4 CELSR1 GALNT3

3.08e-041973031485933986921ff45669d9b7501c8d17050b3e97
ToppCellsaliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KCNK5 CELSR1 GALNT3

3.08e-0419730380b05c8ad9c1edc5dea3236079372475431343fe
ToppCellcritical-Epithelial-FOXN4+|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

POGLUT3 GALNT3 ADAM15

3.12e-041983036b160b3d6a2c1b1641c2c7dcec1a7ef38411fec9
ToppCellwk_08-11-Epithelial-Airway_epithelial_progenitor-epi-prox-progenitor_intermediate_|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CD46 CELSR1 ZNF608

3.12e-041983031eb49b853a9e144e840c660060473fc7873f6478
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

NTN4 CELSR1 GALNT3

3.12e-04198303285f729140b1df029c24f6ca1d2438470ac51794
ToppCellPCW_13-14-Epithelial|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

NTN4 CELSR1 GALNT3

3.12e-0419830348eb6f69a464a34ab32e8d425a22b9d45ec20428
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)|Neuronal / cells hierarchy compared to all cells using T-Statistic

NTN4 ZNF608 MUSK

3.22e-04200303347a510755374c6a66acee326565dfc447993f18
DrugEtilefrine hydrochloride [534-87-2]; Down 200; 18.4uM; HL60; HT_HG-U133A

DCAF17 KCNK5 DHX57 ADAM15 TGFBRAP1

4.99e-061933052930_DN
DrugNalbuphine hydrochloride [23277-43-2]; Down 200; 10.2uM; HL60; HG-U133A

WDR19 KCNK5 CD46 GALNT3 ADAM15

5.37e-061963051379_DN
DrugNisoxetine hydrochloride [57754-86-6]; Down 200; 13uM; MCF7; HT_HG-U133A

DCAF17 SEMA4A CELSR3 SBF1 STAG3

5.93e-062003055516_DN
DiseasePCSK9 protein measurement

PRORP MUSK

3.20e-0426302EFO_0006899
Diseaseasthma

TNFRSF11A PREP TGFBRAP1 MUSK SPEM1

8.86e-04751305MONDO_0004979
Diseasepolyp of colon

NTN4 SMAD9

1.49e-0356302MONDO_0021400
Diseaseheart rate

CD46 CELSR1 MUSK

1.53e-03225303EFO_0004326
Diseasemyeloid white cell count

POGLUT3 CD46 PRORP TGFBRAP1 MUSK

2.35e-03937305EFO_0007988
Diseaseneutrophil count

POGLUT3 CD46 SEMA4A PRORP TGFBRAP1 MUSK

2.35e-031382306EFO_0004833
Diseaseresponse to angiotensin-converting enzyme inhibitor

ZNF608 PREP

2.86e-0378302EFO_0005325

Protein segments in the cluster

PeptideGeneStartEntry
DCCSLESDWIYFHPD

DCAF17

336

Q5H9S7
RHCYCEEGWAPPDCT

ADAM15

671

Q13444
CPPNSRCHDAWEDYS

CELSR1

1881

Q9NYQ6
STPAPCWEEDECLDY

DEDD2

6

Q8WXF8
DEPALYPCCSHWSFP

DISP1

866

Q96F81
YCAHLPRPAEIWDCF

ADAMTS20

1191

P59510
WLPVSDDACYRETCP

CD46

86

P15529
VDCESPDIYPVGWCE

L3MBTL2

581

Q969R5
ECEPWDAQDYHPLIF

KCNK5

401

O95279
CWEHLSDEYVCSRPL

LTBP1

1526

Q14766
TNYPHLCIVDDWICE

INTS2

716

Q9H0H0
ERHYCACLTFWEPAE

SBF1

76

O95248
GHKICDPYAWLEDPD

PREP

21

P48147
LDAHCECFYGWLEPL

GALNT3

276

Q14435
EDDEPDCCNDERYWP

DHX57

136

Q6P158
WELSPAEDEHYCCLP

FAM131C

126

Q96AQ9
YWPALGECEAAPCAL

CELSR3

2951

Q9NYQ7
HCAPLYNDRPWEAAD

NTN4

306

Q9HB63
CVLARDPHCAWDPES

SEMA4A

506

Q9H3S1
KDDWTVCPHCDFPAL

WDR19

1286

Q8NEZ3
WHIPYDEDLVERCSC

PRORP

556

O15091
CAHCPVAWAPDTDDE

SPEM1

121

Q8N4L4
DFRPVCYEEPQHWCS

SMAD9

261

O15198
VYHEYCECPEDPQAW

POGLUT3

136

Q7Z4H8
AEDYCLWCSEGRDPP

TGFBRAP1

696

Q8WUH2
NTHDLTRWELYEPCC

STAG3

711

Q9UJ98
LDCTKHDWAPPRFCE

ZNF608

406

Q9ULD9
SVCLPCGPDEYLDSW

TNFRSF11A

66

Q9Y6Q6
PPTWTYECDEDLIHF

HECTD3

211

Q5T447
HWDPTACARLPHLDY

MUSK

441

O15146