| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | neuropeptide receptor activity | 1.32e-07 | 53 | 18 | 4 | GO:0008188 | |
| GeneOntologyMolecularFunction | neuropeptide binding | 4.69e-06 | 37 | 18 | 3 | GO:0042923 | |
| GeneOntologyMolecularFunction | G protein-coupled peptide receptor activity | 5.35e-06 | 133 | 18 | 4 | GO:0008528 | |
| GeneOntologyMolecularFunction | peptide receptor activity | 6.56e-06 | 140 | 18 | 4 | GO:0001653 | |
| GeneOntologyMolecularFunction | peptide binding | 7.17e-06 | 318 | 18 | 5 | GO:0042277 | |
| GeneOntologyMolecularFunction | poly(U) RNA binding | 4.23e-04 | 34 | 18 | 2 | GO:0008266 | |
| GeneOntologyMolecularFunction | poly-pyrimidine tract binding | 5.58e-04 | 39 | 18 | 2 | GO:0008187 | |
| GeneOntologyMolecularFunction | single-stranded RNA binding | 4.42e-03 | 111 | 18 | 2 | GO:0003727 | |
| GeneOntologyMolecularFunction | G protein-coupled receptor activity | 7.10e-03 | 884 | 18 | 4 | GO:0004930 | |
| GeneOntologyBiologicalProcess | response to chloroquine | 5.57e-09 | 5 | 18 | 3 | GO:1902349 | |
| GeneOntologyBiologicalProcess | chemosensory behavior | 2.47e-06 | 31 | 18 | 3 | GO:0007635 | |
| GeneOntologyBiologicalProcess | neuropeptide signaling pathway | 3.57e-06 | 124 | 18 | 4 | GO:0007218 | |
| GeneOntologyBiologicalProcess | positive regulation of cytokinesis | 1.42e-05 | 55 | 18 | 3 | GO:0032467 | |
| GeneOntologyBiologicalProcess | acute-phase response | 1.76e-05 | 59 | 18 | 3 | GO:0006953 | |
| GeneOntologyBiologicalProcess | mast cell degranulation | 3.48e-05 | 74 | 18 | 3 | GO:0043303 | |
| GeneOntologyBiologicalProcess | mast cell mediated immunity | 3.77e-05 | 76 | 18 | 3 | GO:0002448 | |
| GeneOntologyBiologicalProcess | mast cell activation involved in immune response | 4.08e-05 | 78 | 18 | 3 | GO:0002279 | |
| GeneOntologyBiologicalProcess | regulation of cytokinesis | 8.31e-05 | 99 | 18 | 3 | GO:0032465 | |
| GeneOntologyBiologicalProcess | mast cell activation | 8.82e-05 | 101 | 18 | 3 | GO:0045576 | |
| GeneOntologyBiologicalProcess | positive regulation of cell division | 9.62e-05 | 104 | 18 | 3 | GO:0051781 | |
| GeneOntologyBiologicalProcess | lysosome localization | 1.05e-04 | 107 | 18 | 3 | GO:0032418 | |
| GeneOntologyBiologicalProcess | vacuolar localization | 1.05e-04 | 107 | 18 | 3 | GO:1990849 | |
| GeneOntologyBiologicalProcess | leukocyte degranulation | 1.08e-04 | 108 | 18 | 3 | GO:0043299 | |
| GeneOntologyBiologicalProcess | myeloid cell activation involved in immune response | 1.66e-04 | 125 | 18 | 3 | GO:0002275 | |
| GeneOntologyBiologicalProcess | leukocyte activation involved in immune response | 2.33e-04 | 361 | 18 | 4 | GO:0002366 | |
| GeneOntologyBiologicalProcess | cell activation involved in immune response | 2.43e-04 | 365 | 18 | 4 | GO:0002263 | |
| GeneOntologyBiologicalProcess | acute inflammatory response | 2.47e-04 | 143 | 18 | 3 | GO:0002526 | |
| GeneOntologyBiologicalProcess | myeloid leukocyte mediated immunity | 2.73e-04 | 148 | 18 | 3 | GO:0002444 | |
| GeneOntologyBiologicalProcess | exocytosis | 4.68e-04 | 434 | 18 | 4 | GO:0006887 | |
| GeneOntologyBiologicalProcess | hematopoietic progenitor cell differentiation | 6.30e-04 | 197 | 18 | 3 | GO:0002244 | |
| GeneOntologyBiologicalProcess | regulation of cell division | 6.68e-04 | 201 | 18 | 3 | GO:0051302 | |
| GeneOntologyBiologicalProcess | cytokinesis | 6.97e-04 | 204 | 18 | 3 | GO:0000910 | |
| GeneOntologyBiologicalProcess | regulated exocytosis | 1.94e-03 | 291 | 18 | 3 | GO:0045055 | |
| GeneOntologyBiologicalProcess | positive regulation of cell cycle process | 2.26e-03 | 307 | 18 | 3 | GO:0090068 | |
| GeneOntologyBiologicalProcess | myeloid leukocyte activation | 2.54e-03 | 320 | 18 | 3 | GO:0002274 | |
| GeneOntologyCellularComponent | neuronal cell body membrane | 6.47e-06 | 43 | 18 | 3 | GO:0032809 | |
| GeneOntologyCellularComponent | cell body membrane | 8.49e-06 | 47 | 18 | 3 | GO:0044298 | |
| GeneOntologyCellularComponent | basement membrane | 4.86e-03 | 122 | 18 | 2 | GO:0005604 | |
| GeneOntologyCellularComponent | neuronal cell body | 4.94e-03 | 835 | 18 | 4 | GO:0043025 | |
| GeneOntologyCellularComponent | axon | 6.22e-03 | 891 | 18 | 4 | GO:0030424 | |
| GeneOntologyCellularComponent | cell body | 7.20e-03 | 929 | 18 | 4 | GO:0044297 | |
| MousePheno | decreased pruritus | 4.29e-08 | 7 | 16 | 3 | MP:0010073 | |
| MousePheno | abnormal pruritus | 2.69e-07 | 12 | 16 | 3 | MP:0010071 | |
| MousePheno | abnormal skin physiology | 2.64e-04 | 288 | 16 | 4 | MP:0005501 | |
| MousePheno | increased interleukin-5 secretion | 3.34e-04 | 24 | 16 | 2 | MP:0008702 | |
| Domain | MRGPCRFAMILY | 1.23e-07 | 11 | 18 | 3 | IPR026234 | |
| Domain | SCAN | 1.31e-03 | 56 | 18 | 2 | SM00431 | |
| Domain | SCAN_BOX | 1.40e-03 | 58 | 18 | 2 | PS50804 | |
| Domain | SCAN | 1.40e-03 | 58 | 18 | 2 | PF02023 | |
| Domain | SCAN_dom | 1.40e-03 | 58 | 18 | 2 | IPR003309 | |
| Domain | Retrov_capsid_C | 1.45e-03 | 59 | 18 | 2 | IPR008916 | |
| Domain | GPCR_Rhodpsn_7TM | 3.36e-03 | 670 | 18 | 4 | IPR017452 | |
| Domain | 7tm_1 | 3.49e-03 | 677 | 18 | 4 | PF00001 | |
| Domain | G_PROTEIN_RECEP_F1_1 | 3.64e-03 | 685 | 18 | 4 | PS00237 | |
| Domain | G_PROTEIN_RECEP_F1_2 | 3.76e-03 | 691 | 18 | 4 | PS50262 | |
| Domain | GPCR_Rhodpsn | 3.77e-03 | 692 | 18 | 4 | IPR000276 | |
| Domain | RRM_1 | 1.68e-02 | 208 | 18 | 2 | PF00076 | |
| Domain | RRM | 1.82e-02 | 217 | 18 | 2 | SM00360 | |
| Domain | RRM_dom | 1.98e-02 | 227 | 18 | 2 | IPR000504 | |
| Domain | RRM | 2.03e-02 | 230 | 18 | 2 | PS50102 | |
| Domain | - | 2.27e-02 | 244 | 18 | 2 | 3.30.70.330 | |
| Domain | Nucleotide-bd_a/b_plait | 2.51e-02 | 258 | 18 | 2 | IPR012677 | |
| Pubmed | 1.16e-10 | 3 | 18 | 3 | 28768771 | ||
| Pubmed | 1.16e-10 | 3 | 18 | 3 | 26022362 | ||
| Pubmed | 1.16e-10 | 3 | 18 | 3 | 31119828 | ||
| Pubmed | 1.16e-10 | 3 | 18 | 3 | 27215903 | ||
| Pubmed | 1.16e-10 | 3 | 18 | 3 | 10662793 | ||
| Pubmed | Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs. | 1.16e-10 | 3 | 18 | 3 | 11850634 | |
| Pubmed | 1.16e-10 | 3 | 18 | 3 | 18250432 | ||
| Pubmed | 4.65e-10 | 4 | 18 | 3 | 10504302 | ||
| Pubmed | Characterization of new G protein-coupled adenine receptors in mouse and hamster. | 4.65e-10 | 4 | 18 | 3 | 23608776 | |
| Pubmed | The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia. | 4.65e-10 | 4 | 18 | 3 | 21775281 | |
| Pubmed | 4.65e-10 | 4 | 18 | 3 | 26874069 | ||
| Pubmed | Tick peptides evoke itch by activating MrgprC11/MRGPRX1 to sensitize TRPV1 in pruriceptors. | 4.65e-10 | 4 | 18 | 3 | 33358893 | |
| Pubmed | 4.65e-10 | 4 | 18 | 3 | 28545921 | ||
| Pubmed | Low maternal care enhances the skin barrier resistance of offspring in mice. | 4.65e-10 | 4 | 18 | 3 | 31295326 | |
| Pubmed | Substance P activates Mas-related G protein-coupled receptors to induce itch. | 4.65e-10 | 4 | 18 | 3 | 28219706 | |
| Pubmed | 4.65e-10 | 4 | 18 | 3 | 35882236 | ||
| Pubmed | 4.65e-10 | 4 | 18 | 3 | 11821156 | ||
| Pubmed | 4.65e-10 | 4 | 18 | 3 | 17975009 | ||
| Pubmed | MrgprA3 shows sensitization to chloroquine in an acetone-ether-water mice model. | 4.65e-10 | 4 | 18 | 3 | 29064954 | |
| Pubmed | 4.65e-10 | 4 | 18 | 3 | 36864656 | ||
| Pubmed | 4.65e-10 | 4 | 18 | 3 | 23074220 | ||
| Pubmed | 4.65e-10 | 4 | 18 | 3 | 33727332 | ||
| Pubmed | 4.65e-10 | 4 | 18 | 3 | 32234460 | ||
| Pubmed | MrgprB4 in trigeminal neurons expressing TRPA1 modulates unpleasant sensations. | 1.16e-09 | 5 | 18 | 3 | 34116733 | |
| Pubmed | 1.16e-09 | 5 | 18 | 3 | 17618277 | ||
| Pubmed | Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. | 1.16e-09 | 5 | 18 | 3 | 20004959 | |
| Pubmed | Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+. | 1.16e-09 | 5 | 18 | 3 | 22472648 | |
| Pubmed | Hippocampal short- and long-term plasticity are not modulated by astrocyte Ca2+ signaling. | 1.16e-09 | 5 | 18 | 3 | 20203048 | |
| Pubmed | Cross-sensitization of histamine-independent itch in mouse primary sensory neurons. | 1.16e-09 | 5 | 18 | 3 | 23000623 | |
| Pubmed | 1.16e-09 | 5 | 18 | 3 | 38735364 | ||
| Pubmed | 2.33e-09 | 6 | 18 | 3 | 24549959 | ||
| Pubmed | 2.33e-09 | 6 | 18 | 3 | 33091423 | ||
| Pubmed | 2.33e-09 | 6 | 18 | 3 | 23263443 | ||
| Pubmed | Identification of a bilirubin receptor that may mediate a component of cholestatic itch. | 2.33e-09 | 6 | 18 | 3 | 30657454 | |
| Pubmed | 2.33e-09 | 6 | 18 | 3 | 26216096 | ||
| Pubmed | Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo. | 2.33e-09 | 6 | 18 | 3 | 23364746 | |
| Pubmed | 2.33e-09 | 6 | 18 | 3 | 33876765 | ||
| Pubmed | Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity. | 4.07e-09 | 7 | 18 | 3 | 36693373 | |
| Pubmed | Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes. | 6.51e-09 | 8 | 18 | 3 | 24583173 | |
| Pubmed | Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. | 6.51e-09 | 8 | 18 | 3 | 12909716 | |
| Pubmed | 9.76e-09 | 9 | 18 | 3 | 30886406 | ||
| Pubmed | 9.76e-09 | 9 | 18 | 3 | 12397184 | ||
| Pubmed | 1.39e-08 | 10 | 18 | 3 | 33098765 | ||
| Pubmed | 1.92e-08 | 11 | 18 | 3 | 21151121 | ||
| Pubmed | A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. | 1.92e-08 | 11 | 18 | 3 | 11551509 | |
| Pubmed | Parallel ascending spinal pathways for affective touch and pain. | 4.22e-08 | 14 | 18 | 3 | 33116307 | |
| Pubmed | A brain-to-spinal sensorimotor loop for repetitive self-grooming. | 5.28e-08 | 15 | 18 | 3 | 34932943 | |
| Pubmed | DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon. | 5.28e-08 | 15 | 18 | 3 | 37541195 | |
| Pubmed | 7.88e-08 | 17 | 18 | 3 | 25834056 | ||
| Pubmed | 9.45e-08 | 18 | 18 | 3 | 29045838 | ||
| Pubmed | 1.12e-07 | 19 | 18 | 3 | 24516396 | ||
| Pubmed | C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway. | 1.12e-07 | 19 | 18 | 3 | 38915692 | |
| Pubmed | 1.12e-07 | 19 | 18 | 3 | 22787056 | ||
| Pubmed | Meis1 Regulates Nociceptor Development and Behavioral Response to Tactile Stimuli. | 1.32e-07 | 20 | 18 | 3 | 35875660 | |
| Pubmed | Hierarchical Specification of Pruriceptors by Runt-Domain Transcription Factor Runx1. | 1.54e-07 | 21 | 18 | 3 | 28476948 | |
| Pubmed | 1.54e-07 | 21 | 18 | 3 | 25369838 | ||
| Pubmed | 2.05e-07 | 23 | 18 | 3 | 20096094 | ||
| Pubmed | 2.05e-07 | 23 | 18 | 3 | 16446141 | ||
| Pubmed | 2.34e-07 | 24 | 18 | 3 | 17553423 | ||
| Pubmed | 5.18e-07 | 31 | 18 | 3 | 21300867 | ||
| Pubmed | 5.30e-06 | 7 | 18 | 2 | 21300820 | ||
| Pubmed | 1.56e-05 | 95 | 18 | 3 | 24029230 | ||
| Pubmed | Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations. | 3.56e-05 | 125 | 18 | 3 | 32891193 | |
| Pubmed | Multiple genes encoding zinc finger domains are expressed in human T cells. | 1.17e-04 | 31 | 18 | 2 | 2288909 | |
| Pubmed | 5.00e-04 | 64 | 18 | 2 | 36369321 | ||
| Interaction | ZNF174 interactions | 2.77e-05 | 67 | 18 | 3 | int:ZNF174 | |
| Cytoband | 11p15.1 | 1.71e-06 | 60 | 18 | 3 | 11p15.1 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr11p15 | 1.31e-03 | 564 | 18 | 3 | chr11p15 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr1q32 | 5.69e-03 | 290 | 18 | 2 | chr1q32 | |
| GeneFamily | G protein-coupled receptors, Class A orphans | 1.65e-05 | 78 | 12 | 3 | 262 | |
| GeneFamily | RNA binding motif containing | 8.44e-03 | 213 | 12 | 2 | 725 | |
| Drug | Rfamide | 9.79e-08 | 56 | 18 | 4 | CID000122185 | |
| Disease | colorectal health | 5.87e-03 | 201 | 17 | 2 | EFO_0008460 |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| GNYVFQRRFVQFNGR | 301 | Q8WWN8 | |
| QRRFVQFNGRSLMYF | 306 | Q8WWN8 | |
| VGQVKNFFVNYRRRF | 321 | Q9P2K3 | |
| YFNENFRRGFQAAFR | 331 | Q9GZQ6 | |
| GFAFVQYVNERNARA | 51 | P07910 | |
| NYGFVFINGRNLGRY | 596 | Q8NCI6 | |
| RQFYSVFDRGNNRVG | 376 | P14091 | |
| FFQGNRQRQIIYRVT | 661 | A6NKB5 | |
| QFFRELQQFYNSQGR | 326 | Q02556 | |
| GNEFSVNNGYSRRFR | 1836 | Q8NEV8 | |
| IYFFVGSFRQRQNRQ | 271 | Q96LB0 | |
| NGVRLNNRQVYVGRF | 166 | Q96DU9 | |
| LRARQQTVGGVNYFF | 71 | P01037 | |
| QRYVQGFCRGFQGQL | 246 | O14841 | |
| IYFFVGSFRQRQNRQ | 271 | Q96LB2 | |
| IYFFVGSFRQRQNRQ | 271 | Q96LA9 | |
| FRQRFRQFGYQDSPG | 51 | P17028 | |
| RQRFRRFCYQNTFGP | 56 | P17029 | |
| RFKRAIFQGQYCRNF | 46 | Q9UJW2 |