Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of male mating behavior	HDAC4 HDAC2	7.24e-06	2	56	2	GO:1902437
GeneOntologyBiologicalProcess	regulation of male mating behavior	HDAC4 HDAC2	2.17e-05	3	56	2	GO:1902435
GeneOntologyCellularComponent	acrosomal vesicle	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31C1 SPATA31A5	2.06e-04	206	55	5	GO:0001669
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31C1 SPATA31A5	2.81e-08	12	53	4	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31C1 SPATA31A5	2.81e-08	12	53	4	IPR027970
Domain	TEX13	TEX13C TEX13A	2.37e-05	3	53	2	PF15186
Domain	TEX13	TEX13C TEX13A	2.37e-05	3	53	2	IPR028193
Domain	-	TEX13C TEX13A	3.50e-04	10	53	2	4.10.1060.10
Domain	His_deacetylse_dom	HDAC4 HDAC2	4.27e-04	11	53	2	IPR023801
Domain	Hist_deacetyl	HDAC4 HDAC2	4.27e-04	11	53	2	PF00850
Domain	-	HDAC4 HDAC2	4.27e-04	11	53	2	3.40.800.20
Domain	His_deacetylse	HDAC4 HDAC2	4.27e-04	11	53	2	IPR000286
Domain	ZF_RANBP2_1	TEX13C TEX13A	2.10e-03	24	53	2	PS01358
Domain	Znf_RanBP2	TEX13C TEX13A	2.27e-03	25	53	2	IPR001876
Domain	TPR-like_helical_dom	DNAAF4 SMG5 SEL1L2 TTC33	4.28e-03	233	53	4	IPR011990
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31C1 SPATA31A5	5.40e-14	6	56	5	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31C1 SPATA31A5	5.40e-14	6	56	5	25930072
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31C1 SPATA31A5	3.74e-10	24	56	5	32212159
Pubmed	Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth.	TIAM1 KCNJ6	7.63e-06	3	56	2	9204476
Pubmed	HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology-directed repair.	HDAC4 HDAC2	7.63e-06	3	56	2	38874468
Pubmed	Human transcription factor protein interaction networks.	ARHGAP32 SALL2 MAGED1 RESF1 GLYR1 FBRSL1 SMG5 HERC1 HDAC2 PML MSN	1.47e-05	1429	56	11	35140242
Pubmed	The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases.	HDAC2 PML	1.52e-05	4	56	2	11259576
Pubmed	FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus.	HDAC4 HDAC2	1.52e-05	4	56	2	19276356
Pubmed	Histone deacetylase (HDAC)-1, -2, -4 and -6 expression in human pancreatic adenocarcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients' survival.	HDAC4 HDAC2	1.52e-05	4	56	2	26502922
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	TOX4 SALL2 MAGED1 FBRSL1 HDAC2 PML	1.77e-05	339	56	6	30415952
Pubmed	Impairment of p53 acetylation, stability and function by an oncogenic transcription factor.	HDAC2 PML	2.54e-05	5	56	2	14976551
Pubmed	Positive role of promyelocytic leukemia protein in type I interferon response and its regulation by human cytomegalovirus.	HDAC2 PML	2.54e-05	5	56	2	25812002
Pubmed	Autoacetylation regulates P/CAF nuclear localization.	HDAC4 HDAC2	2.54e-05	5	56	2	19015268
Pubmed	Immediate effects of a single exercise bout on protein O-GlcNAcylation and chromatin regulation of cardiac hypertrophy.	HDAC4 HDAC2	2.54e-05	5	56	2	23624624
Pubmed	Sequestration and inhibition of Daxx-mediated transcriptional repression by PML.	HDAC2 PML	2.54e-05	5	56	2	10669754
Pubmed	MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks.	HDAC2 PML	2.54e-05	5	56	2	18644863
Pubmed	A dynamic role for HDAC7 in MEF2-mediated muscle differentiation.	HDAC4 HDAC2	3.80e-05	6	56	2	11279209
Pubmed	Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression.	NKX2-1 HDAC2	3.80e-05	6	56	2	16510470
Pubmed	Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis.	HDAC4 HDAC2	3.80e-05	6	56	2	24675724
Pubmed	Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor.	HDAC4 HDAC2	5.32e-05	7	56	2	11022042
Pubmed	Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.	HDAC4 HDAC2	5.32e-05	7	56	2	11804585
Pubmed	Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha.	HDAC4 HDAC2	5.32e-05	7	56	2	16951198
Pubmed	Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase.	HDAC4 HDAC2	5.32e-05	7	56	2	19218564
Pubmed	HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF.	HDAC4 HDAC2	5.32e-05	7	56	2	15467736
Pubmed	p21WAF1/CIP1 regulates the p300 sumoylation motif CRD1 through a C-terminal domain independently of cyclin/CDK binding.	HDAC4 HDAC2	7.09e-05	8	56	2	16082198
Pubmed	Differential expression of HDAC and HAT genes in atrophying skeletal muscle.	HDAC4 HDAC2	7.09e-05	8	56	2	26372908
Pubmed	Transcription repressor activity of spleen tyrosine kinase mediates breast tumor suppression.	HDAC4 HDAC2	7.09e-05	8	56	2	16288017
Pubmed	NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation.	HDAC4 HDAC2	9.10e-05	9	56	2	19463978
Pubmed	Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo.	HDAC4 HDAC2	9.10e-05	9	56	2	11466315
Pubmed	Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development.	HDAC4 HDAC2	9.10e-05	9	56	2	15367668
Pubmed	The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment.	HDAC4 HDAC2	9.10e-05	9	56	2	16260608
Pubmed	The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter.	HDAC4 HDAC2	9.10e-05	9	56	2	22989952
Pubmed	Ubc9 sumoylation regulates SUMO target discrimination.	HDAC4 PML	1.14e-04	10	56	2	18691969
Pubmed	Class II histone deacetylases: versatile regulators.	HDAC4 HDAC2	1.14e-04	10	56	2	12711221
Pubmed	Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha.	HDAC2 PML	1.14e-04	10	56	2	18073335
Pubmed	Esco2 is a novel corepressor that associates with various chromatin modifying enzymes.	HDAC4 HDAC2	1.14e-04	10	56	2	18501190
Pubmed	Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression.	HDAC4 HDAC2	1.14e-04	10	56	2	15536134
Pubmed	Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.	HDAC4 HDAC2	1.14e-04	10	56	2	15138260
Pubmed	Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells.	HDAC4 HDAC2	1.14e-04	10	56	2	15619633
Pubmed	Histone Deacetylase 1 Is Essential for Rod Photoreceptor Differentiation by Regulating Acetylation at Histone H3 Lysine 9 and Histone H4 Lysine 12 in the Mouse Retina.	HDAC4 HDAC2	1.14e-04	10	56	2	28028172
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	MAGED1 HDAC4 BTBD10 GPRIN3 SMG5 MSN	1.15e-04	475	56	6	31040226
Pubmed	MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration.	HDAC4 HDAC2	1.39e-04	11	56	2	31223056
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SHROOM4 TRIM66 ARHGAP32 TSC22D1 TOX4 GPRIN3	1.40e-04	493	56	6	15368895
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	SALL2 RESF1 HDAC2 PML	1.55e-04	167	56	4	20362541
Pubmed	A molecular dissection of the repression circuitry of Ikaros.	HDAC4 HDAC2	2.29e-04	14	56	2	12015313
Pubmed	Histone deacetylase expression patterns in developing murine optic nerve.	HDAC4 HDAC2	2.29e-04	14	56	2	25011550
Pubmed	Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin.	HDAC4 HDAC2	2.29e-04	14	56	2	15601857
Pubmed	Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis.	HDAC4 HDAC2	2.29e-04	14	56	2	15537544
Pubmed	Specific control of pancreatic endocrine β- and δ-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9.	HDAC4 HDAC2	2.29e-04	14	56	2	21953612
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	ARHGAP32 TOX4 TIAM1 GLYR1 GPRIN3 HERC1 SLC12A7 TTC33	2.62e-04	1049	56	8	27880917
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	BTBD6 MAGED1 VMAC GLYR1 CPLANE1 PML	2.78e-04	560	56	6	21653829
Pubmed	Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10.	HDAC4 HDAC2	3.01e-04	16	56	2	16873063
Pubmed	Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.	NKX2-1 KANK2	3.01e-04	16	56	2	33253712
Pubmed	HDAC family: What are the cancer relevant targets?	HDAC4 HDAC2	3.83e-04	18	56	2	18824292
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TRIM66 SALL2 RESF1 ZNF460 FBRSL1 KANK2 HDAC2 PML	3.97e-04	1116	56	8	31753913
Pubmed	Constraint and divergence of global gene expression in the mammalian embryo.	HDAC4 ANGPTL4	4.28e-04	19	56	2	25871848
Pubmed	Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone.	HDAC4 HDAC2	4.28e-04	19	56	2	16919237
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TOX4 SALL2 RESF1 ECPAS HDAC2	5.65e-04	418	56	5	34709266
Pubmed	RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing Neurons.	KANK2 HDAC2	5.76e-04	22	56	2	33903225
Pubmed	Rare independent mutations in renal salt handling genes contribute to blood pressure variation.	KCNJ6 SLC12A7	5.76e-04	22	56	2	18391953
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	TRIM66 SALL2 ECPAS	6.42e-04	104	56	3	9205841
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	ARHGAP32 TOX4 MAGED1 TIAM1 ECPAS HDAC2 MSN	6.48e-04	916	56	7	32203420
Pubmed	Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells.	HDAC2 PML	6.87e-04	24	56	2	18454139
Pubmed	MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage.	SALL2 KANK2	7.46e-04	25	56	2	32528060
Pubmed	Transcriptional coactivator with PDZ-binding motif is essential for normal alveolarization in mice.	NKX2-1 ANGPTL4	8.71e-04	27	56	2	19498055
Pubmed	Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.	HDAC4 HDAC2	9.37e-04	28	56	2	31600191
Pubmed	Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.	TSC22D1 HERC1 OGDH HDAC2	9.63e-04	271	56	4	25737280
Pubmed	Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex.	HDAC2 PML	1.08e-03	30	56	2	16449650
Pubmed	Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.	RESF1 HDAC2 PML	1.09e-03	125	56	3	32891193
Pubmed	A human MAP kinase interactome.	ARHGAP32 TSC22D1 TOX4 HDAC4 CPLANE1	1.11e-03	486	56	5	20936779
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	ARHGAP32 RESF1 HDAC4	1.22e-03	130	56	3	12421765
Pubmed	Regulation of lung endoderm progenitor cell behavior by miR302/367.	TIAM1 NKX2-1	1.22e-03	32	56	2	21350014
Pubmed	Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC.	NKX2-1 GLYR1 GPRIN3 TIPARP	1.28e-03	293	56	4	31741433
Pubmed	Histone arginine methylation by Prmt5 is required for lung branching morphogenesis through repression of BMP signaling.	NKX2-1 HDAC2	1.30e-03	33	56	2	29950483
Pubmed	Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.	HDAC2 PML	1.46e-03	35	56	2	22325351
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	4.07e-05	8	56	2	chr9q12
Cytoband	9p13.1	SPATA31A1 SPATA31A3	3.96e-04	24	56	2	9p13.1
Cytoband	15q22	HERC1 PML	5.81e-04	29	56	2	15q22
Cytoband	Xq25	TEX13C TEX13D	1.16e-03	41	56	2	Xq25
Cytoband	Ensembl 112 genes in cytogenetic band chrXq25	TEX13C TEX13D	1.59e-03	48	56	2	chrXq25
Disease	urate measurement, bone density	TOX4 SALL2 FBRSL1 SEL1L2 OGDH TIPARP	5.41e-04	619	49	6	EFO_0003923, EFO_0004531
Disease	IGF-1 measurement	TRIM66 RESF1 AKAP10 CHST11 OGDH	1.27e-03	488	49	5	EFO_0004627
Disease	acute lymphoblastic leukemia (is_marker_for)	HDAC4 HDAC2	1.46e-03	34	49	2	DOID:9952 (is_marker_for)
Disease	cholesteryl esters to total lipids in very large HDL percentage	ANGPTL4 PAFAH1B2	1.64e-03	36	49	2	EFO_0022257
Disease	ornithine measurement	HDAC4 OGDH	2.44e-03	44	49	2	EFO_0009776
Disease	apolipoprotein A 1 measurement	ANGPTL4 PAFAH1B2 FBRSL1 HERC1 RNF145 KANK2	2.70e-03	848	49	6	EFO_0004614
Disease	age at menarche	TRIM66 NKX2-1 FBRSL1 ECPAS PML	2.99e-03	594	49	5	EFO_0004703

Protein segments in the cluster

Peptide	Gene	Start	Entry
ANHMFIPPSAVNEES	FAM227A	526	F5H4B4
AQHQLHAAMFAAPPT	FBRSL1	371	Q9HCM7
AAADIPQDQLVVMHP	BTBD10	431	Q9BSF8
PEMAQPVDPAHNVSR	ANGPTL4	166	Q9BY76
AGPSHVAINAISANM	AKAP10	66	O43572
NNELMADVHFVVGPP	BTBD6	131	Q96KE9
PGEVVMSQAIQPAHA	ACOT12	6	Q8WYK0
TGVPFPQHDANAMDV	ABHD16B	211	Q9H3Z7
AAPPTAAMQQHAVGH	NKX2-1	46	P43699
HAEQQPAPAGMASSQ	RFWD3	16	Q6PCD5
MHPSQDFIQVPVSAE	TIPARP	456	Q7Z3E1
NPARVNHMPSTVDVA	HDAC4	21	P56524
PPTANEMADIQVSAA	MAGED1	56	Q9Y5V3
SMDQDVESPVAIHQP	KCNJ6	16	P48051
NVMVPAAAPSFSQAQ	HERC1	4016	Q15751
PTSQSLADMQDHAPA	ECPAS	611	Q5VYK3
AVNHPTPMAAAANEV	GLYR1	516	Q49A26
AMSTPHVAEPAENEQ	MSN	466	P26038
PNDHNVVSMPPAADV	ARHGAP32	1721	A7KAX9
IMDINDNAPEFVHTP	PCDHB4	231	Q9Y5E5
VANPSHLEAADPVVM	OGDH	371	Q02218
MAASVTNAVPPHNFK	CPLANE1	2636	Q9H799
MAHAAQVGLQDATSP	MT-CO2	1	P00403
AVMAHQNENPAVRPQ	GFRA3	366	O60609
PPVTDNANARMKAHV	DNAAF4	356	Q8WXU2
AVSHAGAPMANAATQ	ACOD1	191	A6NK06
ETMCPVPAAATSNVH	KANK2	386	Q63ZY3
HAPGVQMQAIPEDAV	HDAC2	376	Q92769
PGIMPQVHIQAAAAE	GPRIN3	386	Q6ZVF9
MPTNFTVVPVEAHAD	SLC12A7	1	Q9Y666
AHQNACSTDPPVMVI	SALL2	51	Q9Y467
MSQGDSNPAAIPHAA	PAFAH1B2	1	P68402
GPMQAALQAAAHASV	SMG5	986	Q9UPR3
VSHQTDFGANVPNMP	RESF1	136	Q9HCM1
DMAAQTSPDAHIPVL	SEL1L2	616	Q5TEA6
EAQPMAVVQSVPGAH	PML	436	P29590
PTPMAQAEAQAHLQS	SPATA31A7	491	Q8IWB4
EHNSQPLVAAAMEGP	SHROOM4	731	Q9ULL8
MHQPPESTAAAAAAA	TSC22D1	1	Q15714
PTPMAQAEAQAHLQS	SPATA31C1	351	P0DKV0
DPMEIPANEAHVSAN	CHST11	146	Q9NPF2
SLHPQEVDSVAMAPA	CLEC4F	16	Q8N1N0
PTPMAQAEAQAHLQS	SPATA31A3	491	Q5VYP0
APLAHEIMSGPQAEQ	TEX13D	156	A0A0J9YY54
PVSAVNMETPSIAAH	ZNF460	531	Q14592
NLANHKMPPAAAEET	TIAM1	266	Q13009
PTPMAQAEAQAHLQS	SPATA31A1	491	Q5TZJ5
PTPMAQAEAQAHLQS	SPATA31A5	491	Q5VU36
RFAPPNMQAAEAVSH	VSTM2B	151	A6NLU5
QGMPHSEAQVAAPTA	TEX13C	191	A0A0J9YWL9
AGAAPMETQFPHVEA	TEX13A	216	Q9BXU3
SPQAMASLASDHPQA	TRIM66	721	O15016
PVLQPHAGAEQNVMF	RNF145	591	Q96MT1
MSAPPALQIREANAH	VMAC	1	Q2NL98
AAAAAAAAASMQLPP	TOX4	426	O94842
QQATSEPRAHPAMEA	UBALD1	161	Q8TB05
PAVHAAEMAVQQNPH	TTC33	111	Q6PID6