Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase activator activity	RAB3GAP1 LLGL2 IQGAP2 STXBP5L TBC1D22A ARAP2	3.17e-04	279	66	6	GO:0005096
GeneOntologyMolecularFunction	aminopeptidase activity	DPP9 AOPEP DPP8	3.87e-04	43	66	3	GO:0004177
GeneOntologyMolecularFunction	dipeptidyl-peptidase activity	DPP9 DPP8	6.95e-04	12	66	2	GO:0008239
GeneOntologyMolecularFunction	PDZ domain binding	LLGL2 KCNJ12 ERC2 KCNJ18	7.36e-04	123	66	4	GO:0030165
GeneOntologyMolecularFunction	myosin II binding	LLGL2 STXBP5L	8.20e-04	13	66	2	GO:0045159
GeneOntologyCellularComponent	nuclear DNA-directed RNA polymerase complex	TCEA1 ATXN7L3 GTF2H3 POLR1A	4.51e-04	113	66	4	GO:0055029
GeneOntologyCellularComponent	DNA-directed RNA polymerase complex	TCEA1 ATXN7L3 GTF2H3 POLR1A	4.98e-04	116	66	4	GO:0000428
GeneOntologyCellularComponent	RNA polymerase complex	TCEA1 ATXN7L3 GTF2H3 POLR1A	5.48e-04	119	66	4	GO:0030880
GeneOntologyCellularComponent	mitochondrial nucleoid	MTERF2 CPS1 GRSF1	5.62e-04	51	66	3	GO:0042645
GeneOntologyCellularComponent	nucleoid	MTERF2 CPS1 GRSF1	5.62e-04	51	66	3	GO:0009295
GeneOntologyCellularComponent	AP-3 adaptor complex	VPS18 AP3M2	7.49e-04	13	66	2	GO:0030123
GeneOntologyCellularComponent	HOPS complex	VPS18 VIPAS39	8.72e-04	14	66	2	GO:0030897
Domain	K_chnl_inward-rec_Kir2.2	KCNJ12 KCNJ18	1.31e-05	2	68	2	IPR003272
Domain	K_chnl_inward-rec_Kir_N	KCNJ12 KCNJ18	3.91e-05	3	68	2	IPR013673
Domain	IRK_N	KCNJ12 KCNJ18	3.91e-05	3	68	2	PF08466
Domain	LLGL	LLGL2 STXBP5L	7.80e-05	4	68	2	PF08366
Domain	Lethal2_giant	LLGL2 STXBP5L	7.80e-05	4	68	2	IPR000664
Domain	LLGL2	LLGL2 STXBP5L	7.80e-05	4	68	2	IPR013577
Domain	-	DPP9 DPP8	1.94e-04	6	68	2	2.140.10.30
Domain	DPPIV_N	DPP9 DPP8	1.94e-04	6	68	2	PF00930
Domain	Peptidase_S9B_N	DPP9 DPP8	1.94e-04	6	68	2	IPR002469
Domain	Peptidase_S9	DPP9 DPP8	7.03e-04	11	68	2	PF00326
Domain	Peptidase_S9	DPP9 DPP8	7.03e-04	11	68	2	IPR001375
Domain	K_chnl_inward-rec_Kir_cyto	KCNJ12 KCNJ18	1.52e-03	16	68	2	IPR013518
Domain	IRK	KCNJ12 KCNJ18	1.52e-03	16	68	2	PF01007
Domain	-	KCNJ12 KCNJ18	1.52e-03	16	68	2	2.60.40.1400
Domain	K_chnl_inward-rec_Kir	KCNJ12 KCNJ18	1.52e-03	16	68	2	IPR016449
Domain	-	ACLY CPS1	1.92e-03	18	68	2	3.30.470.20
Domain	ATP_grasp_subdomain_2	ACLY CPS1	5.67e-03	31	68	2	IPR013816
Pubmed	Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal?	DPP9 DPP8	3.77e-06	2	68	2	21711053
Pubmed	DP8 and DP9 have extra-enzymatic roles in cell adhesion, migration and apoptosis.	DPP9 DPP8	3.77e-06	2	68	2	16700509
Pubmed	Identifying natural substrates for dipeptidyl peptidases 8 and 9 using terminal amine isotopic labeling of substrates (TAILS) reveals in vivo roles in cellular homeostasis and energy metabolism.	DPP9 DPP8	3.77e-06	2	68	2	23519473
Pubmed	Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells.	DPP9 DPP8	3.77e-06	2	68	2	33932609
Pubmed	Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation.	DPP9 DPP8	3.77e-06	2	68	2	26242871
Pubmed	Expression profiling of dipeptidyl peptidase 8 and 9 in breast and ovarian carcinoma cell lines.	DPP9 DPP8	3.77e-06	2	68	2	22736146
Pubmed	Role of Kir2.2 in hypercapnic ventilatory response during postnatal development of mouse.	KCNJ12 KCNJ18	3.77e-06	2	68	2	15705530
Pubmed	Structural requirements for catalysis, expression, and dimerization in the CD26/DPIV gene family.	DPP9 DPP8	3.77e-06	2	68	2	12534281
Pubmed	Establishment of a dipeptidyl peptidases (DPP) 8/9 expressing cell model for evaluating the selectivity of DPP4 inhibitors.	DPP9 DPP8	3.77e-06	2	68	2	25464020
Pubmed	DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways.	DPP9 DPP8	3.77e-06	2	68	2	38458339
Pubmed	Decrease of the pro-inflammatory M1-like response by inhibition of dipeptidyl peptidases 8/9 in THP-1 macrophages - quantitative proteomics of the proteome and secretome.	DPP9 DPP8	3.77e-06	2	68	2	32998073
Pubmed	The in vivo expression of dipeptidyl peptidases 8 and 9.	DPP9 DPP8	3.77e-06	2	68	2	19581630
Pubmed	Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain.	KCNJ12 KCNJ18	1.13e-05	3	68	2	8083233
Pubmed	The consequences of disrupting cardiac inwardly rectifying K(+) current (I(K1)) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes.	KCNJ12 KCNJ18	1.13e-05	3	68	2	11410627
Pubmed	Isoforms of dipeptidyl aminopeptidase IV from Pseudomonas sp. WO24: role of the signal sequence and overexpression in Escherichia coli.	DPP9 DPP8	1.13e-05	3	68	2	15866709
Pubmed	Low-affinity spermine block mediating outward currents through Kir2.1 and Kir2.2 inward rectifier potassium channels.	KCNJ12 KCNJ18	1.13e-05	3	68	2	17640933
Pubmed	A genome-wide association study in Caucasian women points out a putative role of the STXBP5L gene in facial photoaging.	STXBP5L POLQ	1.13e-05	3	68	2	23223146
Pubmed	DPP9's Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation.	DPP9 DPP8	1.13e-05	3	68	2	31525884
Pubmed	Dipeptidyl peptidases in atherosclerosis: expression and role in macrophage differentiation, activation and apoptosis.	DPP9 DPP8	1.13e-05	3	68	2	23608773
Pubmed	Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.	DPP9 DPP8	1.13e-05	3	68	2	33731929
Pubmed	DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.	DPP9 DPP8	1.13e-05	3	68	2	33731932
Pubmed	Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation.	KCNJ12 KCNJ18	1.13e-05	3	68	2	10904001
Pubmed	The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9 expression profiles in a mouse model of Crohn's disease.	DPP9 DPP8	1.13e-05	3	68	2	29693275
Pubmed	Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis.	DPP9 DPP8	1.13e-05	3	68	2	16704418
Pubmed	Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases.	DPP9 DPP8	1.13e-05	3	68	2	12662155
Pubmed	The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9.	DPP9 DPP8	1.13e-05	3	68	2	24072711
Pubmed	Mutations in the calcium-binding motifs of CDH23 and the 35delG mutation in GJB2 cause hearing loss in one family.	GJD2 CDH23	1.13e-05	3	68	2	12522556
Pubmed	Assignment of the murine inward rectifier potassium channel Irk2 (Kir2.2) gene to the central region of mouse chromosome 11.	KCNJ12 KCNJ18	2.25e-05	4	68	2	8921409
Pubmed	Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome.	DPP9 DPP8	2.25e-05	4	68	2	29396289
Pubmed	Expression of dipeptidyl peptidase-IV activity and/or structure homologs in human meningiomas.	DPP9 DPP8	2.25e-05	4	68	2	20043068
Pubmed	Functional characterization of inward rectifier potassium ion channel in murine fetal ventricular cardiomyocytes.	KCNJ12 KCNJ18	2.25e-05	4	68	2	20798526
Pubmed	A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction.	KCNJ12 KCNJ18	2.25e-05	4	68	2	32990585
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	INTS10 ATXN7L3 GTF2H3 GNL3L POLR1A PA2G4 ZNF652 SMC4 WHAMM CLP1 TRIP4 GRSF1	3.01e-05	1497	68	12	31527615
Pubmed	Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver.	DPP9 DPP8	3.75e-05	5	68	2	23704821
Pubmed	Vps33b pathogenic mutations preferentially affect VIPAS39/SPE-39-positive endosomes.	VPS18 VIPAS39	3.75e-05	5	68	2	23918659
Pubmed	Expression and prognostic assessment of dipeptidyl peptidase IV and related enzymes in B-cell chronic lymphocytic leukemia.	DPP9 DPP8	3.75e-05	5	68	2	20534982
Pubmed	Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels.	KCNJ12 KCNJ18	3.75e-05	5	68	2	16177047
Pubmed	DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages.	DPP9 DPP8	5.62e-05	6	68	2	30718379
Pubmed	Genetic mapping refines DFNB3 to 17p11.2, suggests multiple alleles of DFNB3, and supports homology to the mouse model shaker-2.	KCNJ12 KCNJ18	5.62e-05	6	68	2	9529344
Pubmed	The inward rectifier potassium channel family.	KCNJ12 KCNJ18	5.62e-05	6	68	2	7580148
Pubmed	DPP9 enzyme activity controls survival of mouse migratory tongue muscle progenitors and its absence leads to neonatal lethality due to suckling defect.	DPP9 DPP8	7.86e-05	7	68	2	28887018
Pubmed	Structural basis of Vps33A recruitment to the human HOPS complex by Vps16.	VPS18 VIPAS39	1.05e-04	8	68	2	23901104
Pubmed	SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery.	VPS18 VIPAS39	1.05e-04	8	68	2	19109425
Pubmed	The quest for juvenile myoclonic epilepsy genes.	GJD2 CASR	1.05e-04	8	68	2	23756480
Pubmed	Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes.	VPS18 VIPAS39	1.05e-04	8	68	2	25783203
Pubmed	Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS.	KCNJ12 KCNJ18	1.05e-04	8	68	2	27930290
Pubmed	Systematic analyses of the ultraviolet radiation resistance-associated gene product (UVRAG) protein interactome by tandem affinity purification.	VPS18 IQGAP2 UGGT1	1.16e-04	48	68	3	26590968
Pubmed	Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity.	VPS18 VIPAS39	1.68e-04	10	68	2	26463206
Pubmed	A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels.	KCNJ12 KCNJ18	1.68e-04	10	68	2	14960569
Pubmed	A physical map of the mouse shaker-2 region contains many of the genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2).	KCNJ12 KCNJ18	2.90e-04	13	68	2	10049592
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	GTF2H3 LLGL2 UBE3B MORC3 TRIP4 COPS7A	3.60e-04	481	68	6	28190767
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	IQGAP2 ACLY SMC4 DNASE1L3 TP53BP2	3.75e-04	313	68	5	20800603
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	TUBB1 PRPSAP1 GNL3L SMC4 GRSF1 CWF19L1	3.80e-04	486	68	6	30940648
Pubmed	Near-atomic resolution visualization of human transcription promoter opening.	TCEA1 GTF2H3	4.44e-04	16	68	2	27193682
Pubmed	Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.	INTS10 ERC2	4.44e-04	16	68	2	22076464
Pubmed	Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution.	TCEA1 GTF2H3	4.44e-04	16	68	2	11313499
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	PRPSAP1 RAB3GAP1 POLR1A IQGAP2 PA2G4 SMC4 CPS1	4.49e-04	704	68	7	29955894
Pubmed	Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.	PA2G4 CDH23	5.03e-04	17	68	2	22951725
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	PRPSAP1 TCEA1 RAB3GAP1 DPP9 PA2G4 ACLY UGGT1 SMC4 DPP8 COPS7A	5.08e-04	1455	68	10	22863883
Pubmed	PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis.	KCNJ12 KCNJ18	5.65e-04	18	68	2	21511879
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	VIPAS39 GNL3L POLR1A TBC1D22A UGGT1 SNRNP35 TRIP4	5.71e-04	733	68	7	34672954
Pubmed	Agrin has a pathological role in the progression of oral cancer.	IQGAP2 PA2G4 ACLY TNNI1	6.13e-04	197	68	4	29872149
Pubmed	Rrn3 becomes inactivated in the process of ribosomal DNA transcription.	GTF2H3 POLR1A	6.30e-04	19	68	2	12646563
Pubmed	Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.	DPP9 DPP8 CIAO2A	7.20e-04	89	68	3	23891004
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	PRPSAP1 GNL3L POLR1A IQGAP2 PA2G4 ACLY UGGT1 SMC4 CLP1	7.41e-04	1257	68	9	37317656
Pubmed	Oxidized thioredoxin-1 restrains the NLRP1 inflammasome.	DPP9 DPP8	7.72e-04	21	68	2	36332009
Pubmed	The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.	HAL CPS1	7.72e-04	21	68	2	27088858
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	INTS10 RAB3GAP1 IQGAP2 ACLY UGGT1 SMC4	7.98e-04	560	68	6	35241646
Pubmed	Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes.	GTF2H3 POLR1A	8.48e-04	22	68	2	9582279
Pubmed	Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.	GTF2H3 POLR1A	9.28e-04	23	68	2	12393749
Pubmed	Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis.	INTS10 CPS1	9.28e-04	23	68	2	12620389
Pubmed	A conserved acetylation switch enables pharmacological control of tubby-like protein stability.	TCEA1 RAB3GAP1 AP3M2 TRIP4	9.72e-04	223	68	4	33187986
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	TUBB1 IQGAP2 PA2G4 UBE3B SMC4 CDH23 MORC3 DPP8 TP53BP2	1.05e-03	1321	68	9	27173435
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	TUBB1 UGGT1 SMC4 CDH23	1.18e-03	235	68	4	30258100
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TCEA1 IQGAP2 PA2G4 AOPEP ZNF652 UGGT1 GRSF1 COPS7A	1.23e-03	1084	68	8	11544199
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	TCEA1 INTS10 GNL3L MORC3 CPS1	1.27e-03	411	68	5	35182466
Pubmed	Penetrance of craniofacial anomalies in mouse models of Smith-Magenis syndrome is modified by genomic sequence surrounding Rai1: not all null alleles are alike.	KCNJ12 KCNJ18	1.28e-03	27	68	2	17273973
Pubmed	A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.	TCEA1 ATXN7L3 POLR1A CLP1 CWF19L1	1.39e-03	419	68	5	28700943
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	PRPSAP1 ACLY UGGT1 CPS1 EMC2	1.43e-03	422	68	5	27342126
Pubmed	Network organization of the human autophagy system.	VPS18 RAB3GAP1 IQGAP2 PA2G4 TP53BP2	1.67e-03	437	68	5	20562859
Pubmed	A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.	TBC1D22A GRSF1	1.69e-03	31	68	2	32245826
Pubmed	Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.	KCNJ12 KCNJ18	1.69e-03	31	68	2	17473172
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	PRPSAP1 PA2G4 ACLY UGGT1 SMC4 CPS1 EMC2 GRSF1 CWF19L1	1.69e-03	1415	68	9	28515276
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	TCEA1 PA2G4 ACLY SMC4 GRSF1 CWF19L1	1.75e-03	653	68	6	33742100
Pubmed	Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein.	FNIP2 RAB3GAP1	1.80e-03	32	68	2	28656962
Pubmed	The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor.	TCEA1 GTF2H3	1.91e-03	33	68	2	9765201
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SEPHS1 IQGAP2 UGGT1 SMC4 ERC2 ABCC2 EMC2 POLQ CCDC191	1.92e-03	1442	68	9	35575683
Cytoband	Ensembl 112 genes in cytogenetic band chr3q13	STXBP5L CASR POLQ CCDC191	3.34e-04	221	68	4	chr3q13
Cytoband	3p14.3	ERC2 DNASE1L3	9.15e-04	30	68	2	3p14.3
Cytoband	3q13.33	STXBP5L POLQ	9.15e-04	30	68	2	3q13.33
Cytoband	Ensembl 112 genes in cytogenetic band chr15q22	DPP8 CIAO2A TRIP4	1.02e-03	132	68	3	chr15q22
Cytoband	15q22.31	CIAO2A TRIP4	1.79e-03	42	68	2	15q22.31
GeneFamily	CD molecules\|DASH family	DPP9 DPP8	1.05e-04	7	41	2	1205
GeneFamily	Potassium voltage-gated channel subfamily J	KCNJ12 KCNJ18	5.90e-04	16	41	2	276
GeneFamily	General transcription factors\|Xeroderma pigmentosum complementation groups\|DNA helicases\|ERCC excision repair associated	TCEA1 GTF2H3	1.46e-03	25	41	2	565
ToppCell	facs-Trachea-nan-24m-Mesenchymal-smooth_muscle_cell_of_trachea\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TUBB1 STXBP5L KCNJ12 CASR SBK2	5.89e-06	168	68	5	6c7b490b6c844d0ea4c07edfc24c02284f9533c4
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CFAP47 LLGL2 ERC2 RIPK4 ARAP2	1.04e-05	189	68	5	7659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	IQGAP2 AP3M2 ITM2A TP53BP2 ARAP2	1.07e-05	190	68	5	91ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell	human_hepatoblastoma-Tumor_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	PRPSAP1 LLGL2 GREB1 ABCC2 DNAH14	1.15e-05	193	68	5	503a979328c68b096680b71359a26f02fafdff35
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CFAP47 LLGL2 ERC2 RIPK4 ARAP2	1.18e-05	194	68	5	f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LLGL2 MTERF2 GAB3 ITM2A ARAP2	1.31e-05	198	68	5	a6b942fe850e287e1cb705684e29218072daf891
Drug	imidazolelactate	DPP9 HAL DPP8	1.35e-06	8	67	3	CID000000793
Drug	5-HTP-DP-hex	TCEA1 HTR3A	8.53e-06	2	67	2	CID000146235
Drug	UAMC00132	DPP9 DPP8	8.53e-06	2	67	2	ctd:C524159
Drug	coproporphyrin I	DPP9 ABCC2 DPP8	1.93e-05	18	67	3	CID000068271
Drug	Muramic acid, N-acetyl [10597-89-4]; Down 200; 13.6uM; MCF7; HT_HG-U133A	GTF2H3 GNL3L TBC1D22A ZNF652 GREB1 CWF19L1	1.98e-05	189	67	6	3262_DN
Drug	Chelidonine monohydrate (+) [476-32-4]; Down 200; 10.8uM; MCF7; HT_HG-U133A	GTF2H3 GNL3L TBC1D22A ZNF652 RIPK4 GREB1	2.43e-05	196	67	6	6236_DN
Drug	SureCN3749646	DPP9 DPP8	2.55e-05	3	67	2	CID011530920
Drug	SureCN3745540	DPP9 DPP8	2.55e-05	3	67	2	CID011974437
Drug	SureCN3749947	DPP9 DPP8	2.55e-05	3	67	2	CID011974435
Drug	ABT-279	DPP9 DPP8	2.55e-05	3	67	2	CID016049769
Drug	Cyanopyrrolidine 38	DPP9 DPP8	2.55e-05	3	67	2	CID010932707
Drug	Cyanopyrrolidine 39	DPP9 DPP8	2.55e-05	3	67	2	CID011117606
Drug	SureCN3748611	DPP9 DPP8	2.55e-05	3	67	2	CID011974325
Drug	Diprolyl-alanine	DPP9 DPP8	2.55e-05	3	67	2	CID000193559
Drug	Propylthiouracil [51-52-5]; Up 200; 23.4uM; MCF7; HT_HG-U133A	CAPN9 ADCY10 STXBP5L TBC1D22A CASR HAL	2.65e-05	199	67	6	4157_UP
Drug	glycylproline 4-nitroanilide	DPP9 DPP8	5.10e-05	4	67	2	ctd:C042892
Drug	prodipine	DPP9 DPP8	8.48e-05	5	67	2	CID000065775
Drug	arginyl(PMC)-pyrrolidine-2-nitrile	DPP9 DPP8	8.48e-05	5	67	2	CID000487437
Drug	alanylproline-4-nitroanilide	DPP9 DPP8	8.48e-05	5	67	2	ctd:C083013
Drug	Protease Inhibitors	DPP9 DPP8	1.27e-04	6	67	2	ctd:D011480
Drug	cathepsin C substrate	DPP9 DPP8	1.27e-04	6	67	2	CID003508173
Drug	NVP-DPP728	DPP9 DPP8	1.27e-04	6	67	2	CID009796290
Drug	MK-251	DPP9 DPP8	1.27e-04	6	67	2	CID000176160
Drug	II 19	DPP9 DPP8	1.27e-04	6	67	2	CID000040321
Disease	progression free survival, response to carboplatin, methylcobalamin deficiency type cblE, ovarian carcinoma	INTS10 IQGAP2 TBC1D22A ARAP2	1.56e-06	39	64	4	EFO_0001075, EFO_0004920, GO_0097328, MONDO_0009354
Disease	cholestasis (implicated_via_orthology)	VPS18 ABCC2	1.65e-04	9	64	2	DOID:13580 (implicated_via_orthology)
Disease	X-21467 measurement	ABCC2 CPS1	1.65e-04	9	64	2	EFO_0020007
Disease	urolithiasis	PDILT CASR CPS1	3.52e-04	63	64	3	MONDO_0024647
Disease	serum alanine aminotransferase measurement, response to combination chemotherapy	SEPHS1 ERC2 GREB1	5.01e-04	71	64	3	EFO_0004735, EFO_0007965
Disease	glutarylcarnitine (C5-DC) measurement	FNIP2 CPS1	6.17e-04	17	64	2	EFO_0800030
Disease	left atrial function	SEPHS1 AOPEP	9.47e-04	21	64	2	EFO_0004294
Disease	platelet-to-lymphocyte ratio	TUBB1 PRPSAP1 IQGAP2 CDH23 ERC2	1.15e-03	363	64	5	EFO_0008446
Disease	urinary uromodulin measurement	STXBP5L PDILT ERC2	1.20e-03	96	64	3	EFO_0005663

Protein segments in the cluster

Peptide	Gene	Start	Entry
LIVAIVGETVYDDEQ	GJD2	36	Q9UKL4
RQLEDLVIEAVYADV	COPS7A	126	Q9UBW8
YSDEEEIQHVVEVIQ	CASR	246	P41180
VSIDVIVYAILNVDE	HTR3A	61	P46098
EEVNVIEDLINNYVE	ARAP2	1281	Q8WZ64
YVLDLDVDFESQVIE	AOPEP	26	Q8N6M6
EERIIFIIDEAQFVD	ADCY10	636	Q96PN6
SVRVIVYVEDINDEA	CDH23	1191	Q9H251
CVEVQEINEEEYLVI	CIAO2A	66	Q9H5X1
EGEFDLVQRIIYEVD	TP53BP2	936	Q13625
LEAIAQEIYADLVED	ATXN7L3	16	Q14CW9
DYIEEEVIDEKGNVV	RAB3GAP1	706	Q15042
VLLEDVSNVYGDVEI	INTS10	346	Q9NVR2
YVEVYEINNEDVDAL	GRSF1	221	Q12849
VIKDNVVVVYEVLEE	AP3M2	101	P53677
AEFEVHEVYAVDVLV	PA2G4	216	Q9UQ80
YDGIIHAELVVIDDE	PALMD	436	Q9NP74
QDLETDDFEIVVILE	KCNJ12	286	Q14500
YALVVLAEEELVVID	LLGL2	351	Q6P1M3
EVDVYDEEEININLR	GREB1	1371	Q4ZG55
LLSEEQRVDYVQVDE	GAB3	551	Q8WWW8
YQSVVELSAEVVEEV	CWF19L1	371	Q69YN2
DLQQVNYDVDVVDEI	MORC3	911	Q14149
NYDVDVVDEILGQVV	MORC3	916	Q14149
EIETNIVAVERITEY	ABCC2	1261	Q92887
NTEDREEEIKQIEVY	ERC2	411	O15083
LEDETYVEEIANILQ	MTERF2	71	Q49AM1
EIEYEVVRDADDNCV	CPS1	631	P31327
EVALENNEFVEVVIE	HAL	71	P42357
SVKEIDELVEVYTDV	DNASE1L3	161	Q13609
LYEEVDESEVEVIHV	DPP9	276	Q86TI2
EVEESEYVVITVRNE	FNIP2	561	Q9P278
ELLYEVAEEDVVQVA	POLQ	2541	O75417
ILYEENDESEVEIIH	DPP8	301	Q6V1X1
IEDHDEIYAEAQELV	CCDC191	81	Q8NCU4
IVAEEVRIVEDYAQK	DNAH14	2321	Q0VDD8
QTYVVREDLVAVEEI	ITM2A	191	O43736
IAIIVDDIIDDVESF	PRPSAP1	251	Q14558
EQIVEVGEELINEYA	EMC2	31	Q15006
LRAEVEEYDVVISTV	DHRS7C	206	A6NNS2
EVTAEELEYVLNAVL	CAPN9	536	O14815
QTLVRAEVDELYEEV	SBK2	51	P0C263
IVNTLYEIDFDVEIQ	CFAP47	1831	Q6ZTR5
QDLEEEVAELFYDVI	PDILT	181	Q8N807
QDLETDDFEIVVILE	KCNJ18	286	B7U540
EIREELEQYTTEIVQ	POLR1A	156	O95602
EDIIEEVTVGYIREN	IQGAP2	641	Q13576
VVEYSDVILEVLDAR	GNL3L	131	Q9NVN8
LVVTQEDVELAYQEA	SEPHS1	226	P49903
YTEGAELIENVLEVV	TUBB1	106	Q9H4B7
EELGSQIEEAIYQEI	TCEA1	166	P23193
VVDELEIQFYEIQLE	WHAMM	381	Q8TF30
VVEELVSADVIDLFD	RIPK4	766	P57078
EIVSLEVRLQYDVED	STXBP5L	551	Q9Y2K9
DELGEIIQSVYEDLV	ACLY	791	P53396
VDVVVVLDQERLYNE	CLP1	251	Q92989
ELYEEAVDLALQVDV	VPS18	721	Q9P253
AKVEVVDEERYDIEA	TNNI1	71	P19237
VIDQHEIFVDYELER	SNRNP35	116	Q16560
DYIVVDSIDIAQECV	SMC4	641	Q9NTJ3
VQILQEYVNLVEDVD	VIPAS39	421	Q9H9C1
VVFICEYIEAEEVDT	TBC1D22A	331	Q8WUA7
AYEDDVLLIDVIQDD	TOPAZ1	856	Q8N9V7
TILDDIEVYEEQISF	UBE3B	541	Q7Z3V4
LDVSEEIIQYVLSIE	TRIP4	26	Q15650
EIIQYVLSIESAEEI	TRIP4	31	Q15650
VVDLIIALQEDSYVV	TM6SF2	76	Q9BZW4
EEEEVSYKREQIIVE	ZNF652	106	Q9Y2D9
YELLTSANEVIVEEI	GTF2H3	101	Q13889
LEEVDSVVAAEYELE	UGGT1	1096	Q9NYU2