Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnitric-oxide synthase binding

DNM3 DNM1 DNM2

6.06e-0522703GO:0050998
GeneOntologyMolecularFunctionprotein serine/threonine kinase binding

DNM3 DNM1 DNM2

7.92e-0524703GO:0120283
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

DOCK1 CCDC88A DENND1B SH3BP5L PLEKHG5 DENND3

1.59e-04231706GO:0005085
GeneOntologyMolecularFunctionD2 dopamine receptor binding

DNM1 DNM2

2.52e-047702GO:0031749
GeneOntologyMolecularFunctiongrowth hormone receptor binding

JAK1 JAK3

5.35e-0410702GO:0005131
GeneOntologyMolecularFunctionnon-membrane spanning protein tyrosine kinase activity

JAK1 JAK3 FGR

5.62e-0446703GO:0004715
GeneOntologyMolecularFunctionmicrotubule binding

EZR CCDC88A KIF1A DNM3 DNM1 DNM2

7.35e-04308706GO:0008017
GeneOntologyBiologicalProcesssynaptic vesicle budding from presynaptic endocytic zone membrane

DNM3 DNM1 DNM2

6.06e-0611703GO:0016185
GeneOntologyBiologicalProcesssynaptic vesicle budding

DNM3 DNM1 DNM2

1.65e-0515703GO:0070142
GeneOntologyBiologicalProcesssynaptic vesicle transport

KIF1A DNM3 DNM1 DNM2

3.38e-0554704GO:0048489
GeneOntologyBiologicalProcessvesicle scission

DNM1 DNM2

3.40e-053702GO:0099050
GeneOntologyBiologicalProcessestablishment of organelle localization

EZR KIF1A DNM3 FGR DNM1 PTGDR TRAPPC9 PCM1 DNM2

9.24e-05546709GO:0051656
GeneOntologyBiologicalProcesssynaptic vesicle localization

KIF1A DNM3 DNM1 DNM2

9.96e-0571704GO:0097479
GeneOntologyBiologicalProcessorganelle localization

EZR KIF1A ASPM DNM3 FGR DNM1 PTGDR TRAPPC9 PCM1 DNM2

1.24e-047037010GO:0051640
GeneOntologyBiologicalProcesscellular response to interleukin-9

JAK1 JAK3

2.36e-047702GO:0071355
GeneOntologyBiologicalProcessinterleukin-9-mediated signaling pathway

JAK1 JAK3

2.36e-047702GO:0038113
GeneOntologyBiologicalProcessmRNA 3'-splice site recognition

SF3A3 SF3A2

2.36e-047702GO:0000389
GeneOntologyBiologicalProcessvesicle budding from membrane

DNM3 DNM1 TRAPPC9 DNM2

2.60e-0491704GO:0006900
MousePhenoabnormal neocortex morphology

LHX2 CUX2 CCDC88A ASPM

2.31e-0548494MP:0008547
MousePhenoabnormal brain size

LHX2 CUX2 CCDC88A HECTD3 ASPM TRAPPC9 BDNF PCM1

4.29e-05375498MP:0000771
MousePhenodecreased brain size

LHX2 CCDC88A HECTD3 ASPM TRAPPC9 BDNF PCM1

6.98e-05295497MP:0000774
MousePhenoabnormal hallux morphology

EIF3C EIF3CL

1.20e-045492MP:0009049
DomainNPIP

NPIPA5 NPIPA1 NPIPA3 NPIPA7

1.86e-0714714IPR009443
DomainDynamin_central

DNM3 DNM1 DNM2

1.04e-066713IPR000375
DomainGED

DNM3 DNM1 DNM2

1.04e-066713SM00302
DomainGED

DNM3 DNM1 DNM2

1.04e-066713PS51388
DomainDynamin_M

DNM3 DNM1 DNM2

1.04e-066713PF01031
DomainDynamin_GTPase_CS

DNM3 DNM1 DNM2

1.04e-066713IPR019762
DomainGED_dom

DNM3 DNM1 DNM2

1.04e-066713IPR020850
DomainGED

DNM3 DNM1 DNM2

1.04e-066713PF02212
DomainGED

DNM3 DNM1 DNM2

1.04e-066713IPR003130
DomainG_DYNAMIN_1

DNM3 DNM1 DNM2

1.82e-067713PS00410
DomainDYNc

DNM3 DNM1 DNM2

1.82e-067713SM00053
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31A5

1.13e-0512713PF15371
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31A5

1.13e-0512713IPR027970
DomainEIF3C_N_dom

EIF3C EIF3CL

1.42e-052712IPR008905
DomaineIF-3c_N

EIF3C EIF3CL

1.42e-052712PF05470
DomainEIF3C

EIF3C EIF3CL

1.42e-052712IPR027516
DomainG_DYNAMIN_dom

DNM3 DNM1 DNM2

1.86e-0514713IPR030381
DomainG_DYNAMIN_2

DNM3 DNM1 DNM2

1.86e-0514713PS51718
DomainDynamin_GTPase

DNM3 DNM1 DNM2

2.32e-0515713IPR001401
DomainDynamin_N

DNM3 DNM1 DNM2

2.32e-0515713PF00350
DomainDynamin_SF

DNM3 DNM1 DNM2

2.32e-0515713IPR022812
DomainPH_dom-like

JAK1 JAK3 EZR KIF1A OSBPL3 DNM3 DNM1 PLEKHG5 DNM2

3.27e-05426719IPR011993
DomainTransc_factor_DP_C

TFDP1 TFDP2

4.26e-053712IPR014889
DomainDP

TFDP1 TFDP2

4.26e-053712PF08781
DomainDP

TFDP1 TFDP2

4.26e-053712SM01138
DomainTranscrpt_fac_DP

TFDP1 TFDP2

4.26e-053712IPR015648
DomainTyr_kinase_non-rcpt_Jak/Tyk2

JAK1 JAK3

8.51e-054712IPR016251
Domain-

ZBP1 ETV7 EIF3C TFDP1 TFDP2 EIF3CL

1.80e-042187161.10.10.10
DomainWHTH_DNA-bd_dom

ZBP1 ETV7 EIF3C TFDP1 TFDP2 EIF3CL

3.15e-04242716IPR011991
DomainTyrKc

JAK1 JAK3 ERBB4 FGR

3.51e-0488714SM00219
DomainTyr_kinase_cat_dom

JAK1 JAK3 ERBB4 FGR

3.51e-0488714IPR020635
DomainPROTEIN_KINASE_TYR

JAK1 JAK3 ERBB4 FGR

5.09e-0497714PS00109
DomainTyr_kinase_AS

JAK1 JAK3 ERBB4 FGR

5.09e-0497714IPR008266
DomainPH

KIF1A OSBPL3 DNM3 DNM1 PLEKHG5 DNM2

6.56e-04278716SM00233
DomainPH_DOMAIN

KIF1A OSBPL3 DNM3 DNM1 PLEKHG5 DNM2

6.69e-04279716PS50003
DomainPH_domain

KIF1A OSBPL3 DNM3 DNM1 PLEKHG5 DNM2

6.81e-04280716IPR001849
Domain-

EZR KIF1A OSBPL3 DNM3 DNM1 PLEKHG5 DNM2

7.02e-043917172.30.29.30
DomainE2F_TDP

TFDP1 TFDP2

7.66e-0411712PF02319
DomainE2F_TDP

TFDP1 TFDP2

7.66e-0411712SM01372
DomainE2F_WHTH_DNA-bd_dom

TFDP1 TFDP2

7.66e-0411712IPR003316
DomainFERM_domain

JAK1 JAK3 EZR

8.56e-0449713IPR000299
DomainFERM_1

JAK1 JAK3 EZR

9.08e-0450713PS00660
DomainFERM_2

JAK1 JAK3 EZR

9.08e-0450713PS00661
DomainFERM_3

JAK1 JAK3 EZR

9.08e-0450713PS50057
DomainBand_41_domain

JAK1 JAK3 EZR

9.08e-0450713IPR019749
DomainB41

JAK1 JAK3 EZR

9.08e-0450713SM00295
DomainZnf_C2H2_matrin

SF3A3 SF3A2

9.18e-0412712IPR000690
DomainKinase-like_dom

JAK1 JAK3 ERBB4 RIOK1 DNM3 FGR DNM1 DNM2

1.02e-03542718IPR011009
DomainuDENN

DENND1B DENND3

1.45e-0315712PF03456
DomainPkinase_Tyr

JAK1 JAK3 ERBB4 FGR

1.48e-03129714PF07714
DomainUDENN

DENND1B DENND3

1.65e-0316712PS50946
DomainDDENN

DENND1B DENND3

1.65e-0316712PS50947
DomainDENN

DENND1B DENND3

1.65e-0316712SM00799
DomaindDENN

DENND1B DENND3

1.65e-0316712SM00801
DomainDENN

DENND1B DENND3

1.65e-0316712PF02141
DomaindDENN_dom

DENND1B DENND3

1.65e-0316712IPR005112
DomainuDENN_dom

DENND1B DENND3

1.65e-0316712IPR005113
DomaindDENN

DENND1B DENND3

1.65e-0316712PF03455
DomainDENN

DENND1B DENND3

1.65e-0316712PS50211
DomainDENN_dom

DENND1B DENND3

1.65e-0316712IPR001194
DomainPINT

EIF3C EIF3CL

1.65e-0316712SM00088
DomainPH

KIF1A OSBPL3 DNM3 DNM1 DNM2

1.79e-03229715PF00169
DomainARM-type_fold

DOCK1 NCAPD3 WAPL CAND2 ASPM RYR3

1.82e-03339716IPR016024
DomainPCI_dom

EIF3C EIF3CL

1.87e-0317712IPR000717
DomainPCI

EIF3C EIF3CL

1.87e-0317712PF01399
DomainSer-Thr/Tyr_kinase_cat_dom

JAK1 JAK3 ERBB4 FGR

1.89e-03138714IPR001245
DomainZF_MATRIN

SF3A3 SF3A2

2.10e-0318712PS50171
PathwayREACTOME_RECYCLING_PATHWAY_OF_L1

EZR DNM3 DNM1 DNM2

1.07e-0537534MM15102
PathwayREACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING

DNM3 DNM1 DNM2

1.77e-0514533M10122
PathwayREACTOME_RECYCLING_PATHWAY_OF_L1

EZR DNM3 DNM1 DNM2

3.33e-0549534M891
PathwayREACTOME_L1CAM_INTERACTIONS

EZR DNM3 DNM1 DNM2

1.21e-0468534MM14968
PathwayREACTOME_ACTIVATION_OF_NOXA_AND_TRANSLOCATION_TO_MITOCHONDRIA

TFDP1 TFDP2

1.38e-045532M26903
PathwayKEGG_MEDICUS_PATHOGEN_HTLV_1_P12_TO_JAK_STAT_SIGNALING_PATHWAY

JAK1 JAK3

2.88e-047532M47581
PathwayBIOCARTA_STAT3_PATHWAY

JAK1 JAK3

3.83e-048532MM1576
PathwayBIOCARTA_STAT3_PATHWAY

JAK1 JAK3

3.83e-048532M22063
PathwayREACTOME_DISEASES_OF_MITOTIC_CELL_CYCLE

UBE2E1 TFDP1 TFDP2

3.86e-0438533M39005
PathwayREACTOME_ACTIVATION_OF_PUMA_AND_TRANSLOCATION_TO_MITOCHONDRIA

TFDP1 TFDP2

4.91e-049532M26946
PathwayREACTOME_INTERLEUKIN_9_SIGNALING

JAK1 JAK3

4.91e-049532M27861
PathwayBIOCARTA_IL22BP_PATHWAY

JAK1 JAK3

4.91e-049532MM1419
PathwayBIOCARTA_IL22BP_PATHWAY

JAK1 JAK3

4.91e-049532M8066
PathwayREACTOME_INTERLEUKIN_21_SIGNALING

JAK1 JAK3

6.12e-0410532M27898
PathwayBIOCARTA_IL4_PATHWAY

JAK1 JAK3

7.46e-0411532MM1413
PathwayBIOCARTA_IL4_PATHWAY

JAK1 JAK3

7.46e-0411532M5415
PathwayREACTOME_GAP_JUNCTION_DEGRADATION

DNM1 DNM2

7.46e-0411532MM14732
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_CYCLE_GENES

CNOT3 TFDP1 TFDP2

8.18e-0449533M27614
PathwayREACTOME_INTERLEUKIN_2_SIGNALING

JAK1 JAK3

8.94e-0412532M27893
PathwayREACTOME_GAP_JUNCTION_DEGRADATION

DNM1 DNM2

8.94e-0412532M15243
PathwayWP_SYNAPTIC_VESICLE_PATHWAY

DNM3 DNM1 DNM2

9.20e-0451533M39457
PathwayREACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1

TFDP1 TFDP2

1.05e-0313532M1015
PathwayREACTOME_L1CAM_INTERACTIONS

EZR DNM3 DNM1 DNM2

1.09e-03121534M872
PathwayPID_TXA2PATHWAY

FGR DNM1 PTGDR

1.21e-0356533M99
PathwayREACTOME_INTERLEUKIN_15_SIGNALING

JAK1 JAK3

1.23e-0314532M27858
PathwayPID_SHP2_PATHWAY

JAK1 JAK3 BDNF

1.27e-0357533M100
PathwayREACTOME_NETRIN_1_SIGNALING

DOCK1 EZR

1.41e-0315532MM14965
PathwayPID_TRKR_PATHWAY

DOCK1 DNM1 BDNF

1.55e-0361533M187
PathwayREACTOME_SIGNALING_BY_NTRKS

DNM3 DNM1 BDNF DNM2

1.59e-03134534M3574
PathwayREACTOME_TRANSCRIPTION_OF_E2F_TARGETS_UNDER_NEGATIVE_CONTROL_BY_P107_RBL1_AND_P130_RBL2_IN_COMPLEX_WITH_HDAC1

TFDP1 TFDP2

1.61e-0316532M26940
PathwayBIOCARTA_IL7_PATHWAY

JAK1 JAK3

1.61e-0316532M1296
PathwayBIOCARTA_IL7_PATHWAY

JAK1 JAK3

1.61e-0316532MM1420
PathwayWP_DYRK1A_INVOLVEMENT_REGARDING_CELL_PROLIFERATION_IN_BRAIN_DEVELOPMENT

DNM1 TFDP1 TFDP2

1.62e-0362533M45532
PathwayWP_NCRNAS_INVOLVED_IN_STAT3_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA

JAK1 JAK3

1.82e-0317532M39512
PathwayREACTOME_PURINE_CATABOLISM

NUDT16 PNP

1.82e-0317532M842
PathwayREACTOME_ABERRANT_REGULATION_OF_MITOTIC_G1_S_TRANSITION_IN_CANCER_DUE_TO_RB1_DEFECTS

TFDP1 TFDP2

1.82e-0317532M38998
PathwayBIOCARTA_BARRESTIN_SRC_PATHWAY

FGR DNM1

1.82e-0317532M111
PathwayWP_IL9_SIGNALING

JAK1 JAK3

1.82e-0317532M39644
PathwayBIOCARTA_BARRESTIN_SRC_PATHWAY

FGR DNM1

1.82e-0317532MM1491
PathwayREACTOME_CLATHRIN_MEDIATED_ENDOCYTOSIS

DNM3 TOR1B DNM1 DNM2

1.97e-03142534MM15499
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_G2_CELL_CYCLE_ARREST

TFDP1 TFDP2

2.04e-0318532M27633
PathwayREACTOME_PURINE_CATABOLISM

NUDT16 PNP

2.04e-0318532MM15439
PathwayREACTOME_CLATHRIN_MEDIATED_ENDOCYTOSIS

DNM3 TOR1B DNM1 DNM2

2.13e-03145534M27753
PathwayREACTOME_MEMBRANE_TRAFFICKING

DENND1B KIF1A DNM3 TOR1B DNM1 TRAPPC9 DENND3 DNM2

2.28e-03630538M11480
PathwayREACTOME_TRANSCRIPTION_OF_E2F_TARGETS_UNDER_NEGATIVE_CONTROL_BY_DREAM_COMPLEX

TFDP1 TFDP2

2.28e-0319532M26939
PathwayREACTOME_VESICLE_MEDIATED_TRANSPORT

DENND1B KIF1A DNM3 TOR1B DNM1 TRAPPC9 DENND3 DNM2

2.63e-03645538MM15232
Pubmed

The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.

SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5

2.82e-10674420850414
Pubmed

Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.

SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5

2.82e-10674425930072
Pubmed

Dynamin and endocytosis.

DNM3 DNM1 DNM2

9.25e-09374312383797
Pubmed

Disruption of the coxsackievirus and adenovirus receptor-homodimeric interaction triggers lipid microdomain- and dynamin-dependent endocytosis and lysosomal targeting.

DNM3 DNM1 DNM2

9.25e-09374324273169
Pubmed

Dynamin: characteristics, mechanism of action and function.

DNM3 DNM1 DNM2

9.25e-09374312511974
Pubmed

Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis.

DNM3 DNM1 DNM2

9.25e-09374328395327
Pubmed

Dynamin at the actin-membrane interface.

DNM3 DNM1 DNM2

9.25e-09374312517701
Pubmed

Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors.

DNM3 DNM1 DNM2

9.25e-09374324046449
Pubmed

Overlapping role of dynamin isoforms in synaptic vesicle endocytosis.

DNM3 DNM1 DNM2

3.69e-08474321689597
Pubmed

Trans-infection but not infection from within endosomal compartments after cell-to-cell HIV-1 transfer to CD4+ T cells.

DNM3 DNM1 DNM2

3.69e-08474322846998
Pubmed

Chronic lithium treatment elicits its antimanic effects via BDNF-TrkB dependent synaptic downscaling.

DNM3 DNM1 BDNF

3.69e-08474328621662
Pubmed

Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling.

NPIPA5 NPIPA1 NPIPA3

3.69e-08474318055785
Pubmed

Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER.

DNM3 DNM1 DNM2

9.22e-0857439722593
Pubmed

Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons.

DNM3 DNM1 DNM2

1.84e-07674323640057
Pubmed

Dynamin 1- and 3-Mediated Endocytosis Is Essential for the Development of a Large Central Synapse In Vivo.

DNM3 DNM1 DNM2

1.84e-07674327251629
Pubmed

A clathrin-dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell-T cell transmission.

DNM3 DNM1 DNM2

1.84e-07674318602423
Pubmed

Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.

SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5

1.94e-072474432212159
Pubmed

A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis.

DNM3 DNM1 DNM2

3.22e-07774315252009
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

JAK1 CNPPD1 EZR WAPL KIF1A ANXA7 DNM3 EIF3C DNM1 SF3A2 CNOT3 PCM1 RYR3 DNM2

4.73e-071285741435914814
Pubmed

Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily.

DNM3 DNM1 DNM2

5.14e-07874324282027
Pubmed

Major histocompatibility complex class-II molecules promote targeting of human immunodeficiency virus type 1 virions in late endosomes by enhancing internalization of nascent particles from the plasma membrane.

DNM3 DNM1 DNM2

7.70e-07974323170932
Pubmed

Expression and localisation of dynamin and syntaxin during neural development and neuromuscular synapse formation.

DNM3 DNM1 DNM2

1.10e-061074310398046
Pubmed

Protein partners of dynamin-1 in the retina.

DNM3 DNM1 DNM2

1.10e-061074323746204
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

NCAPD3 RIOK1 WAPL CCDC88A HECTD3 OSBPL3 DNM1 RBM47 DENND3 DNM2

1.19e-06650741038777146
Pubmed

Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation.

DNM3 DNM1 DNM2

3.31e-061474320802490
Pubmed

Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers.

JAK1 JAK3

4.47e-06274218559588
Pubmed

JAK1 rs310241 and JAK3 rs3008 Genotypes May Increase Susceptibility to Psoriasis: A Case Control Study.

JAK1 JAK3

4.47e-06274232877908
Pubmed

Classical dynamin DNM1 and DNM3 genes attain maximum expression in the normal human central nervous system.

DNM3 DNM1

4.47e-06274224673776
Pubmed

Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation.

DNM1 DNM2

4.47e-06274221670293
Pubmed

Differential appearance of dynamin in constitutive and regulated exo-endocytosis: a single-cell multiplex RT-PCR study.

DNM1 DNM2

4.47e-06274216028072
Pubmed

Positive selection of a gene family during the emergence of humans and African apes.

NPIPA1 NPIPA8

4.47e-06274211586358
Pubmed

Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa.

DNM1 DNM2

4.47e-06274222977254
Pubmed

Motor protein KIF1A is essential for hippocampal synaptogenesis and learning enhancement in an enriched environment.

KIF1A BDNF

4.47e-06274222365548
Pubmed

Ezrin expression is altered in mice lymphatic metastatic hepatocellular carcinoma and subcellular fractions upon Annexin 7 modulation in-vitro.

EZR ANXA7

4.47e-06274227914826
Pubmed

Janus kinase-1 and 3 in ankylosing spondylitis.

JAK1 JAK3

4.47e-06274229530480
Pubmed

EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.

EIF3C EIF3CL

4.47e-06274236157221
Pubmed

Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients.

DNM3 DNM1

4.47e-06274220700106
Pubmed

Absence of gain-of-function JAK1 and JAK3 mutations in adult T cell leukemia/lymphoma.

JAK1 JAK3

4.47e-06274220697856
Pubmed

Recurrent JAK1 and JAK3 somatic mutations in T-cell prolymphocytic leukemia.

JAK1 JAK3

4.47e-06274224048415
Pubmed

Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin.

CCDC88A DNM2

4.47e-06274225061227
Pubmed

Mechanism of Janus kinase 3-catalyzed phosphorylation of a Janus kinase 1 activation loop peptide.

JAK1 JAK3

4.47e-06274212559972
Pubmed

Dynamin is primed at endocytic sites for ultrafast endocytosis.

DNM3 DNM1

4.47e-06274235809574
Pubmed

The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3.

DNM3 DNM1

4.47e-06274238641407
Pubmed

Dynamin-mediated lipid acquisition is essential for Chlamydia trachomatis development.

DNM1 DNM2

4.47e-06274225116793
Pubmed

Dynamin regulates L cell secretion in human gut.

DNM1 DNM2

4.47e-06274234274446
Pubmed

Dynamin at actin tails.

DNM1 DNM2

4.47e-06274211782545
Pubmed

A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis.

DNM3 DNM1

4.47e-06274224963135
Pubmed

Janus kinase inhibition prevents cancer- and myocardial infarction-mediated diaphragm muscle weakness in mice.

JAK1 JAK3

4.47e-06274226864813
Pubmed

Cux2 expression regulated by Lhx2 in the upper layer neurons of the developing cortex.

LHX2 CUX2

4.47e-06274231708105
Pubmed

Crystal structure of the dynamin tetramer.

DNM3 DNM1

4.47e-06274226302298
Pubmed

Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses.

DNM3 DNM1

4.47e-06274222308498
Pubmed

Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses.

JAK1 JAK3

4.47e-06274224365136
Pubmed

Dynamin 2-dependent endocytosis is essential for mouse oocyte development and fertility.

DNM1 DNM2

4.47e-06274232065700
Pubmed

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.

JAK1 JAK3

4.47e-06274225193870
Pubmed

An intramolecular signaling element that modulates dynamin function in vitro and in vivo.

DNM1 DNM2

4.47e-06274219515832
Pubmed

Cooperating JAK1 and JAK3 mutants increase resistance to JAK inhibitors.

JAK1 JAK3

4.47e-06274225352124
Pubmed

EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts.

DNM3 DNM1 DNM2

6.15e-061774337042948
Pubmed

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.

JAK1 JAK3

1.34e-05374211909529
Pubmed

Frequency and prognostic implications of JAK 1-3 aberrations in Down syndrome acute lymphoblastic and myeloid leukemia.

JAK1 JAK3

1.34e-05374221537335
Pubmed

Particular Role of JAK/STAT3 Signaling in Functional Control of Mesenchymal Progenitor Cells.

JAK1 JAK3

1.34e-05374229308566
Pubmed

Jak3 maps to chromosome 8.

JAK1 JAK3

1.34e-0537428662243
Pubmed

Fes mediates the IL-4 activation of insulin receptor substrate-2 and cellular proliferation.

JAK1 JAK3

1.34e-05374211160325
Pubmed

A role for Cajal bodies in the final steps of U2 snRNP biogenesis.

SF3A3 SF3A2

1.34e-05374215316075
Pubmed

A synaptic locus for TrkB signaling underlying ketamine rapid antidepressant action.

DNM1 BDNF

1.34e-05374234407417
Pubmed

Structural organization and chromosomal mapping of JAK3 locus.

JAK1 JAK3

1.34e-0537428934548
Pubmed

Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane.

DNM1 DNM2

1.34e-05374222371560
Pubmed

Dp1 is largely dispensable for embryonic development.

TFDP1 TFDP2

1.34e-05374215282318
Pubmed

Involvement of JAK1, JAK2, and JAK3 in Stimulation of Functional Activity of Mesenchymal Progenitor Cells by Fibroblast Growth Factor.

JAK1 JAK3

1.34e-05374227905037
Pubmed

Loss of mutL homolog-1 (MLH1) expression promotes acquisition of oncogenic and inhibitor-resistant point mutations in tyrosine kinases.

JAK1 JAK3

1.34e-05374227436342
Pubmed

Implication of JAK1, JAK2, and JAK3 in the Realization of Proliferation and Differentiation Potential of Mesenchymal Progenitor Cells In Vitro.

JAK1 JAK3

1.34e-05374227383175
Pubmed

Positive regulation of interleukin-4-mediated proliferation by the SH2-containing inositol-5'-phosphatase.

JAK1 JAK3

1.34e-05374210875931
Pubmed

Age-associated inflammation inhibits epidermal stem cell function.

JAK1 JAK3

1.34e-05374222972935
Pubmed

Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase.

DNM1 DNM2

1.34e-05374215895076
Pubmed

JAK mutations in high-risk childhood acute lymphoblastic leukemia.

JAK1 JAK3

1.34e-05374219470474
Pubmed

TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3.

CAND2 CNOT3

1.34e-05374212207886
Pubmed

Interaction domains and nuclear targeting signals in subunits of the U2 small nuclear ribonucleoprotein particle-associated splicing factor SF3a.

SF3A3 SF3A2

1.34e-05374221349847
Pubmed

Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9.

DNM3 DNM1

1.34e-05374235065714
Pubmed

Cell biology of IL-7, a key lymphotrophin.

JAK1 JAK3

1.34e-05374215996891
Pubmed

SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis.

DNM1 DNM2

1.34e-05374215703209
Pubmed

Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes.

DNM1 DNM2

1.34e-05374224145164
Pubmed

The Expression of Dynamin 1, 2, and 3 in Human Hepatocellular Carcinoma and Patient Prognosis.

DNM3 DNM2

1.34e-05374232573516
Pubmed

The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling.

DNM1 DNM2

1.34e-05374211483962
Pubmed

Identification of inactivating mutations in the JAK1, SYNJ2, and CLPTM1 genes in prostate cancer cells using inhibition of nonsense-mediated decay and microarray analysis.

JAK1 CLPTM1

1.34e-05374216102578
Pubmed

Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550).

JAK1 JAK3

1.34e-05374221383241
Pubmed

Genomic structure and developmental expression of the mouse cell cycle regulatory transcription factor DP1.

TFDP1 TFDP2

1.34e-0537429000141
Pubmed

The impact of CPT1B rs470117, LEPR rs1137101 and BDNF rs6265 polymorphisms on the risk of developing obesity in an Italian population.

CPT1B BDNF

1.34e-05374234176754
Pubmed

The Janus kinase family of protein tyrosine kinases and their role in signaling.

JAK1 JAK3

1.34e-05374210526570
Pubmed

Hi-JAK-ing the ubiquitin system: The design and physicochemical optimisation of JAK PROTACs.

JAK1 JAK3

1.34e-05374232001089
Pubmed

Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.

DNM3 DNM1 DNM2

2.61e-052774319723784
Pubmed

Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivo.

SF3A3 SF3A2

2.67e-05474215647371
Pubmed

Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family.

TFDP1 TFDP2

2.67e-0547429027491
Pubmed

Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits.

DNM1 DNM2

2.67e-05474220059951
Pubmed

Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation.

SF3A3 SF3A2

2.67e-05474211533230
Pubmed

Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.

EIF3C EIF3CL

2.67e-05474210504338
Pubmed

Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta.

JAK1 JAK3

2.67e-0547429553136
Pubmed

DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo.

TFDP1 TFDP2

2.67e-0547428755520
Pubmed

JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling.

JAK1 JAK3

2.67e-05474211133764
Pubmed

Regulation of the Jak/STAT signalling pathway.

JAK1 JAK3

2.67e-0547428593242
Pubmed

Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.

WAPL EIF3CL

2.67e-05474218187866
Pubmed

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition.

JAK1 JAK3

2.67e-05474224843152
InteractionZBBX interactions

HECTD3 DNM3 DNM1 DNM2

3.48e-0631684int:ZBBX
InteractionSOCS2 interactions

JAK1 JAK3 EZR NCAPD3 ERBB4

2.11e-0599685int:SOCS2
InteractionFER interactions

JAK1 DNM3 DNM1 DNM2

2.43e-0550684int:FER
Cytoband16p13.11

NPIPA5 NPIPA1 NPIPA3

6.96e-062374316p13.11
CytobandEnsembl 112 genes in cytogenetic band chr9q12

SPATA31A7 SPATA31A5

7.13e-058742chr9q12
Cytoband9p13.1

SPATA31A1 SPATA31A3

6.91e-04247429p13.1
CytobandEnsembl 112 genes in cytogenetic band chr2q34

ERBB4 UNC80

2.43e-0345742chr2q34
Cytoband9q34

TOR1B DNM1

3.47e-03547429q34
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

KIF1A OSBPL3 DNM3 DNM1 PLEKHG5 DNM2

2.51e-06206356682
GeneFamilyTranscription factor Dp family

TFDP1 TFDP2

1.09e-053352987
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

DENND1B DENND3

1.06e-0325352504
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

JAK1 EZR

4.21e-03503521293
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK1 ERBB4 DENND1B OSBPL3 DNM3

1.58e-05189745830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellnormal_Pleural_Fluid-T/NK_cells-NK|normal_Pleural_Fluid / Location, Cell class and cell subclass

JAK1 ZBP1 FGR PTGDR TFDP2

1.70e-0519274559dd4f5ae9f1cca78adf60b71661092ef09e6641
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

JAK1 NPIPA5 ZNF485 PTGDR TFDP2

1.79e-051947456be74e4ba631b0c46cef2c580553f4c1ed29579e
ToppCellmild_COVID-19-Classical_Monocyte|World / disease group, cell group and cell class (v2)

CCDC88A APLP2 FGR RBM47 PNP

1.93e-051977455d826f4d7b7a46847c67e6bef38eb860bc808a6c
ToppCellSigmoid-B_cell-B_cell_IgG_Plasma|B_cell / Region, Cell class and subclass

JAK1 ZBP1 WAPL ETV7 RYR3

1.98e-05198745305d7ae9b070ac7211638a5282374c02bf13af40
ToppCellnormal_Lung-T/NK_cells-NK|T/NK_cells / Location, Cell class and cell subclass

JAK1 FGR PTGDR DENND3 TFDP2

2.02e-05199745407ae8575bb4dec7fe10d48ceb8f32a03f5ac1bb
ToppCellmild-HLA-DR+_CD83+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CCDC88A APLP2 FGR RBM47 DENND3

2.07e-05200745934c2efc780318c66d667ca75be0de350361d351
ToppCell(05)_Ciliated-(3)_72hpi|(05)_Ciliated / shred by cell type and Timepoint

C10orf67 ASPM CPT1B DENND3

3.79e-05113744eaa5bc8f8183b353ee1e7618e99220eb3684cd60
ToppCellmetastatic_Lymph_Node-Fibroblasts-COL13A1+_matrix_FBs|Fibroblasts / Location, Cell class and cell subclass

EZR NUDT16 DENND1B CLPTM1

9.22e-051427440e0f8bb956ff89dc98e8fa56f8acac33e01a26dd
ToppCellMild/Remission-B_naive-1|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

WAPL EIF3C NPIPA7 EIF3CL

9.47e-05143744bd3f5fbd4e9e4dc414682db5607494f3ce988deb
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CLPTM1 DNM1 LRRC75A RYR3

1.32e-04156744895927228c93cd090303984c5be6ebfb59ed6f3a
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD8-Trm/em_CD8|GI_large-bowel / Manually curated celltypes from each tissue

CAND2 FGR PTGDR ASAH2B

1.36e-04157744d85304af4cd3b8aaedc5362a8223537e1b9dbec2
ToppCellICU-SEP-Lymphocyte-T_NK-NK_CD56bright|ICU-SEP / Disease, Lineage and Cell Type

DOCK1 ETV7 PTGDR TFDP2

1.39e-0415874453a942cdab4a3c6813dbe11368135a24b8de1880
ToppCellAdult-Immune-mast_cell-D175|Adult / Lineage, Cell type, age group and donor

JAK3 PTGDR PLEKHG5 TFDP1

1.43e-041597449f53fe2e0f25448d62a591c8e528e9a49b5400d5
ToppCellICU-NoSEP-Lymphocyte-T_NK-Treg|ICU-NoSEP / Disease, Lineage and Cell Type

JAK3 ETV7 ZNF485 DNM3

1.43e-04159744d065ec02a4f3672ba53d4fea66029f1ce68f367f
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NPIPA5 DNM1 BDNF RYR3

1.61e-04164744d167c7a987b9b35d1e7725c803df4f9cd5380e47
ToppCellControl-Myeloid-MoAM1,_IL1R2|Control / Condition, Lineage and Cell class

ZBP1 ETV7 CPT1B DENND3

1.72e-04167744ab6029ba037b6a499da8758864c44e174cde5587
ToppCellASK454-Immune-NK_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

JAK1 ZBP1 PTGDR TFDP2

1.84e-0417074484705434234bf2fbb5256bd5a1f6ab54c01c5a51
ToppCellASK454-Immune-NK_cell|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

JAK1 ZBP1 PTGDR TFDP2

1.93e-04172744c9e738c3540ee09b08805b1cdb66b4a0d9d40d33
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZBP1 PTGDR DENND3 TFDP2

2.06e-041757448fb8c4b9e2d9b7d737f59cd9bd3dc2bca5a8dfc4
ToppCellLPS_only-Myeloid-Neutrophils|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

APLP2 FGR PTGDR RBM47

2.24e-04179744d0a03e498afcfeb657037889685ecd77bed07e6c
ToppCell3'_v3-GI_small-bowel-Lymphocytic_NK|GI_small-bowel / Manually curated celltypes from each tissue

FGR PTGDR DENND3 TFDP2

2.24e-04179744535bdfdd990ba9ee3edc8f3ad15297f8fb5a266e
ToppCellLPS_only-Myeloid-Neutrophils-Neutrophils|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

APLP2 FGR PTGDR RBM47

2.24e-04179744d034651a5a355a58f5e15db627869f4feebdfe35
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal-Ependyma|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EZR CAND2 CPT1B RBM47

2.29e-04180744729f0d7af573c7796d8e28e6eec3af2fc0bd33a2
ToppCellLPS-IL1RA-Myeloid-Neutrophils-Neutrophils|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

APLP2 FGR PTGDR RBM47

2.29e-04180744c0c07937839652e01df10cc1e70aa005800ea6f6
ToppCellLPS-IL1RA-Myeloid-Neutrophils|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

APLP2 FGR PTGDR RBM47

2.29e-04180744079c199425dd3c220f03c6dca1823946f07580a1
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal-ependymal_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EZR CAND2 CPT1B RBM47

2.29e-041807449ef79a7c60227e352ac166c7274adb31f585f5ca
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CAND2 COQ6 RBM47 LRRC75A

2.39e-04182744c98da2db197b1531204e116600ff51891e5c17af
ToppCell5'-Adult-SmallIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZBP1 ALDH1L2 OSBPL3 DENND3

2.39e-04182744626aabfd9ac662c1d189f7c4b660482914d9e669
ToppCellCOVID-19_Mild-CD4+_T_activated|COVID-19_Mild / Disease condition and Cell class

WAPL EIF3C NPIPA7 EIF3CL

2.39e-04182744877b6e611626628e709568747512f2827ebb2795
ToppCell5'-Adult-SmallIntestine-Hematopoietic-Plasma_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZBP1 ALDH1L2 OSBPL3 DENND3

2.39e-04182744a00abff41c12b71d5860c494b8c722d649fd5f36
ToppCellCOVID-19_Mild-NK_activated|COVID-19_Mild / Disease condition and Cell class

WAPL EIF3C NPIPA7 EIF3CL

2.44e-0418374422bd05135906d0ecc4ba8c2e0a666093d1bf3b8f
ToppCellCOVID-19_Mild-CD8+_T_activated|COVID-19_Mild / Disease condition and Cell class

ZBP1 ETV7 FGR PTGDR

2.44e-04183744ac1ca5d613fa9888ccc63cb0bdce95aefd02cdd7
ToppCellnucseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ZBP1 DENND1B ALDH1L2 OSBPL3

2.54e-041857443b77bc49cd3740acc025e162a36282ac09e12198
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|bone_marrow / Manually curated celltypes from each tissue

CCDC88A ASPM APLP2 RBM47

2.60e-04186744e82d5e7a976b9cfa2b4640c7a7cd1cfea19c4806
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

KIF1A DNM3 UNC80 RYR3

2.65e-041877445258674d0346e5c51a4b965efcdc1790c970845d
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK-NK_dim-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

JAK1 ZBP1 PTGDR TFDP2

2.65e-041877440bca79cea4886b66350c56c61859bd71e1e7a85c
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_NK-natural_killer_cell-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

JAK1 KIF1A PTGDR TFDP2

2.70e-04188744a29c43a91ed1364a09d5abab6efa51b8061bce74
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-Plasma_cell|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

NCAPD3 OSBPL3 ASPM UNC80

2.70e-0418874434873972dff9284dfcd26bb698c9d1df007f1cbb
ToppCellCOVID-19_Moderate-NK_activated|COVID-19_Moderate / disease group, cell group and cell class

ZBP1 FGR PTGDR TFDP2

2.76e-041897448f9f1e71857bed6d59c4b087b6a6970f30fd86be
ToppCell15-Distal-Immune-Hematopoietic,_Natural_Killer_Cell|Distal / Age, Tissue, Lineage and Cell class

JAK3 ZBP1 FGR PTGDR

2.76e-04189744281a7ccb18edf542a7756f2f90b20594436097f9
ToppCellFetal_29-31_weeks-Immune-monocyte-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CCDC88A FGR RBM47 DENND3

2.81e-04190744ad297172a74a80ed5c10f921e15efd1da0fd2d6b
ToppCellFibroblasts-CD55+_Fibroblasts|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

EZR APLP2 DENND3 PNP

2.81e-04190744b4088128f5acf53f43244c9af9fe44e033f1a57a
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

EZR C10orf67 DENND3 BDNF

2.81e-0419074430b50d183d7649146eb1e79b47ba897355f1998a
ToppCell11.5-Distal-Immune-Hematopoietic,_Natural_Killer_Cell|Distal / Age, Tissue, Lineage and Cell class

ZBP1 OSBPL3 FGR PTGDR

2.81e-04190744caac193f12705d7cabf6f0b148f0ff267e9ffef6
ToppCellPBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

APLP2 EIF3C FGR EIF3CL

2.87e-04191744c9f3bdb5c0a90268cab24a0fe4c3a8290fcedeb8
ToppCellPBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

APLP2 EIF3C FGR EIF3CL

2.93e-04192744b86476037ddf8904c1d8a6b3763af7242c031cf3
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D175|Adult / Lineage, Cell type, age group and donor

CCDC88A ABCB5 FGR RBM47

2.93e-04192744733491e932350e3c216a626cc49c3cd3fe970a82
ToppCellURO|World / Disease, Lineage and Cell Type

JAK3 NUDT16 APLP2 FGR

2.99e-04193744421dc0996c6c973f88e90197b651255ae4dd13a2
ToppCellCD8+_Memory_T_cell-CV-0|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

JAK1 FGR PTGDR TFDP2

2.99e-04193744995781d87a919c0380750878bafe584342bb83ad
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK1 EZR ERBB4 OSBPL3

2.99e-04193744263d185af6ed80e639f864e4966268e0862c61dc
ToppCellCOPD-Myeloid|COPD / Disease state, Lineage and Cell class

CCDC88A APLP2 FGR RBM47

2.99e-04193744f58552e286aa27e592497ad78776f58f8ee09841
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK1 EZR ERBB4 OSBPL3

2.99e-0419374480e058c224749b5fe0ba3e944b48317c2371cb63
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK1 EZR ERBB4 OSBPL3

2.99e-04193744b991fbbb4618401624f0b3045f0e81a606d3a763
ToppCell3'_v3-Lung-Lymphocytic_NK|Lung / Manually curated celltypes from each tissue

JAK1 ZBP1 PTGDR TFDP2

2.99e-04193744a98ee519e0da93ae4a2dcdda1ee8b4138dec131b
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

JAK1 ZBP1 FGR PTGDR

2.99e-04193744db9378c5bb5c27b321957a05dcabf40e97a3b725
ToppCellInt-URO-Lymphocyte-T_NK-NK|Int-URO / Disease, Lineage and Cell Type

JAK1 ZBP1 PTGDR TFDP2

2.99e-041937445c7942f630fc69374df34ee3602ad973b6ced17a
ToppCell3'_v3-Lung-Lymphocytic_NK-NK_CD16|Lung / Manually curated celltypes from each tissue

JAK1 ZBP1 PTGDR TFDP2

3.05e-041947443337042eef91a49f621058785723228cf4dfdad4
ToppCellBLOOD--(0)_NK_cells_(CD56bright-like)| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

JAK1 FGR PTGDR TFDP2

3.05e-041947448d4368d546bba17a420e172bfb5f1f337fe23c44
ToppCellIIF-Lymphocyte-T_NK-NK|IIF / Disease, Lineage and Cell Type

JAK1 ZBP1 PTGDR TFDP2

3.11e-04195744464ce05cb52f78aee22d3baa6641b37bd53aae16
ToppCellfacs-Brain_Myeloid-Hippocampus|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAK1 KRT13 DNM2 PNP

3.11e-04195744a1478021a3ed0e779716393124ca2a7770c433b7
ToppCellIPF-Myeloid|IPF / Disease state, Lineage and Cell class

CCDC88A APLP2 FGR RBM47

3.11e-04195744fdeb958aeaa00f3fc25c4e59efbbc6f4a572c9ce
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ZBP1 CCDC88A ALDH1L2 OSBPL3

3.11e-04195744bb30ac112f8c42d113fa83a9b662e40c0685bb1e
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CUX2 KIF1A DNM3 PCM1

3.11e-04195744b25c534fc6320d4da6437ef1b27e32a5d5256f3e
ToppCellControl-Myeloid|Control / Disease state, Lineage and Cell class

CCDC88A APLP2 FGR RBM47

3.11e-0419574446ce2e403ca5d757e5ba17349b6c7ce5cde1f195
ToppCellT/NK_cells-CD56dim_NK_cell|World / Lineage and Cell class

JAK1 ZBP1 FGR PTGDR

3.11e-041957446124e87cb9061bf8918377fb4a79084079ddfc16
ToppCellHealthy-Classical_Monocyte|Healthy / disease group, cell group and cell class

CCDC88A APLP2 FGR RBM47

3.17e-0419674427d24aa2fd4521cf7e410688ed3b11b2d9700dd2
ToppCellwk_20-22-Hematologic_Lymphocytic-NK-Intermediate_NK|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

JAK1 ZBP1 FGR PTGDR

3.17e-04196744a2f938022a080202bce5bb157d13b86b69054468
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK-NK_dim-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

JAK1 ZBP1 PTGDR TFDP2

3.17e-041967445b5cf6f70534661d694f47359b6595b4580876c3
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK-NK_dim|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

JAK1 ZBP1 PTGDR TFDP2

3.17e-041967448e1ed30256a031bb90dac1f167e074c68efbed74
ToppCellT_cells-CD56_dim_CD16+_NK_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

FGR PTGDR DENND3 TFDP2

3.17e-0419674407b557b8530c19ca5b31ad2eac00c36ef1939266
ToppCelllymphoid-NK_cell|lymphoid / Lineage, cell class and subclass

ZBP1 FGR PTGDR DENND3

3.17e-041967440c7fb03ef782256f61624afc5c1bfaed9f1005fb
ToppCelllymphoid-NK_cell-NK_cell|lymphoid / Lineage, cell class and subclass

ZBP1 FGR PTGDR DENND3

3.17e-041967445e6238fe131e349013c60a73c99f84a6be7955ef
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 DENND1B OSBPL3 RBM47

3.17e-04196744eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell390C-Myeloid-Dendritic-cDC_proliferating_1|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

NCAPD3 ASPM TFDP1 PCM1

3.17e-0419674436ed1918f70b6f5760bb088b15ce422998055cc7
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_NK-NK_dim-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

JAK1 ZBP1 PTGDR TFDP2

3.23e-0419774476304df40f87224f8e415677e3ee8fb183fe0c03
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_monocytic-monocyte|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CCDC88A APLP2 FGR RBM47

3.23e-04197744ec46aa307ce5774b4c0fcba64514f2d0cab3c4f9
ToppCellnormal_Pleural_Fluid-T/NK_cells-NK|T/NK_cells / Location, Cell class and cell subclass

ZBP1 FGR PTGDR DENND3

3.23e-0419774452e6b772f8c3a623b1b0c28119918fb9935803e1
ToppCellILEUM-non-inflamed-(3)_MNP|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

CCDC88A NUDT16 FGR RBM47

3.23e-0419774464fdc12e7ffade669cc1de081b10e84a27f0d1b5
ToppCellPBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CCDC88A APLP2 FGR RBM47

3.23e-041977446e96a6c2576f52b72aeab1e41f47a0af05ff327a
ToppCelltumor_Lung-T/NK_cells-NK|T/NK_cells / Location, Cell class and cell subclass

FGR PTGDR DENND3 TFDP2

3.23e-04197744e9fac2c923179b2b8b0500076421c6fb09960b56
ToppCellSepsis-ICU-SEP-Lymphocyte-T/NK-NK_CD56bright|ICU-SEP / Disease, condition lineage and cell class

DOCK1 ETV7 PTGDR TFDP2

3.23e-04197744c187e3fc2160b0165eb039cf09a6e621016068b7
ToppCellPBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCDC88A APLP2 FGR RBM47

3.23e-04197744a80be1081f3ed0aceea69a33be21bca6bc354472
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_monocytic|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CCDC88A APLP2 FGR RBM47

3.23e-04197744b91016249b3585aa3536e96af18e4f1b1d2d5ce4
ToppCellBLOOD--(0)_NK_cell| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

JAK1 FGR PTGDR TFDP2

3.23e-04197744ce35c3ba6db897235d0107fa7dadc5013bf4da24
ToppCellBLOOD--(0)_NK_cells_(CD56dim-like)| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

JAK1 FGR PTGDR TFDP2

3.23e-041977444c15b3386b89191af9332738e597549e2305de26
ToppCellCOVID-19_Severe-NK_activated|World / disease group, cell group and cell class

JAK1 ZBP1 PTGDR TFDP2

3.23e-04197744a60db36d1a192998e3ded63e0c7c08d41689f95f
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

JAK1 FGR PTGDR TFDP2

3.23e-04197744b6689a3e01e4c285fc2cb33f8c437078722a3892
ToppCellsevere-Lymphocytic-NK_cells|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

JAK1 FGR PTGDR TFDP2

3.29e-041987446ef22f33b43e9adceea11738e3cba0e8b59b4ec6
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CCDC88A NUDT16 APLP2 FGR

3.29e-0419874474591eba5dbb2d77d416309326a26be969e4ad42
ToppCellCOVID-19_Severe-NK|COVID-19_Severe / Disease condition and Cell class

FGR PTGDR DENND3 TFDP2

3.29e-04198744742c4d6016cfa48444a5919a885ab8d02cad7e18
ToppCellBLOOD--(3)_Classical_Mono-2| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

CCDC88A APLP2 FGR RBM47

3.29e-0419874434c23181c227f65209cde4382248253282f6ac6e
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCDC88A APLP2 FGR RBM47

3.29e-04198744cf0fda1a24449cfd8ed56ffc7841d8accb187949
ToppCellPBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCDC88A APLP2 FGR RBM47

3.29e-04198744d347462ba6cb1c5a59c86dffbbe914cbc1e9cf16
ToppCellPBMC-Convalescent-Myeloid|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCDC88A APLP2 FGR RBM47

3.29e-041987443973bbc1bfb5b08dd1becd5e4bb5899b15df9e55
ToppCellCOVID-19_Convalescent-Myeloid-Classical_Monocyte|COVID-19_Convalescent / Disease group, lineage and cell class

CCDC88A APLP2 FGR RBM47

3.29e-04198744ca58c62d7f732631af1f7cabaa785757d031c011
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

JAK1 ZBP1 PTGDR TFDP2

3.29e-041987440e918e9db9b884f5328d438e90efe065e27266ee
ToppCellASK452-Immune-Macrophages|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

CCDC88A APLP2 FGR RBM47

3.29e-0419874492293d389bf7d76ba057613e573c2595676ded85
ToppCellPBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

CCDC88A APLP2 FGR RBM47

3.29e-04198744c5a22846bccff948f90bc1d5fe309907dcd08348
ToppCellCOVID-19_Mild-Myeloid-Classical_Monocyte|COVID-19_Mild / Disease group, lineage and cell class

CCDC88A APLP2 FGR RBM47

3.29e-04198744e78d027a095473af555762a4d542a73f5bb2e166
DiseaseCharcot-Marie-Tooth disease dominant intermediate B (implicated_via_orthology)

DNM3 DNM1 DNM2

1.12e-075673DOID:0110197 (implicated_via_orthology)
Diseasecentronuclear myopathy 1 (implicated_via_orthology)

DNM3 DNM1 DNM2

1.12e-075673DOID:0111223 (implicated_via_orthology)
Diseasemicrocytic anemia (implicated_via_orthology)

DNM3 DNM1 DNM2

1.12e-075673DOID:11252 (implicated_via_orthology)
Diseasecollagen disease (implicated_via_orthology)

DNM3 DNM1 DNM2

2.43e-0612673DOID:854 (implicated_via_orthology)
Diseasehematologic cancer (implicated_via_orthology)

JAK1 JAK3 CUX2

3.15e-0613673DOID:2531 (implicated_via_orthology)
Diseasedevelopmental and epileptic encephalopathy (implicated_via_orthology)

DNM3 DNM1 DNM2

3.15e-0613673DOID:0112202 (implicated_via_orthology)
DiseasePEHO syndrome

CCDC88A KIF1A

1.52e-053672C1850055
DiseaseLennox-Gastaut syndrome

CUX2 DNM1

7.57e-056672C0238111
Diseasedisease of cellular proliferation (implicated_via_orthology)

JAK1 JAK3

1.06e-047672DOID:14566 (implicated_via_orthology)
Diseasehereditary spastic paraplegia (implicated_via_orthology)

DNM3 DNM1 DNM2

1.29e-0443673DOID:2476 (implicated_via_orthology)
DiseasePrecursor T-Cell Lymphoblastic Leukemia-Lymphoma

JAK3 CNOT3 DNM2

2.42e-0453673C1961099
DiseaseT-cell acute lymphoblastic leukemia (is_implicated_in)

JAK1 JAK3

2.76e-0411672DOID:5603 (is_implicated_in)
Diseaseprimary autosomal recessive microcephaly (is_implicated_in)

NCAPD3 ASPM

5.97e-0416672DOID:0070296 (is_implicated_in)
Diseaselongitudinal BMI measurement

DOCK1 ERBB4 RBM47

8.72e-0482673EFO_0005937
Diseaseparental longevity

ERBB4 CUX2 DENND1B RBM47 LRRC75A RYR3

8.99e-04494676EFO_0007796
DiseaseAutosomal Recessive Primary Microcephaly

NCAPD3 ASPM

1.14e-0322672C3711387
Diseasechloride measurement

CUX2 BDNF

1.98e-0329672EFO_0009284
DiseaseEpileptic encephalopathy

DNM1 RYR3

2.12e-0330672C0543888

Protein segments in the cluster

PeptideGeneStartEntry
MMYLEERRLVHRDLA

ERBB4

831

Q15303
YLDAANMSMRVRRHS

BDNF

116

P23560
RYERAVSMHNAAREM

SH3BP5L

136

Q7L8J4
MRLRHLAFKAMLYQD

ABCB5

766

Q2M3G0
MNARERGRLMYRLAD

ALDH1L2

501

Q3SY69
MRQHRQFMDRTHYLL

ASAH2B

1

P0C7U1
HICNMRYRAFRRMQV

COQ6

106

Q9Y2Z9
LRATMEAYSRMANRD

ANXA7

376

P20073
FHNYRSRMRREMLVE

CUX2

1216

O14529
ARLNRRMDAFAQMDL

DENND3

416

A2RUS2
RMHRLHMRYQALKQA

ASPM

2346

Q8IZT6
HRYHVRMLETILRML

CNOT3

176

O75175
YESHRAAAMARRKLM

RBM47

201

A0AV96
AMRNLYAMHRRLQRH

PTGDR

221

Q13258
TVDDKMSLRLHYRMR

JAK1

96

P23458
RHSLMAKYIMDLERL

JAK3

231

P52333
YMEMFQRAQALRRRA

NPIPA1

181

Q9UND3
EAMLNDRRRMALENY

APLP2

461

Q06481
AYMERMNYIHRDLRA

FGR

371

P09769
LRYAILMQMRFDGRL

NUDT16

41

Q96DE0
QAQRRDEMLRMYHAL

DNM1

721

Q05193
YHRRVGMVQELLRMV

LRRC75A

51

Q8NAA5
YRPHQARETLRVMME

MED7

126

O43513
EMREQYEAMAERNRR

KRT13

276

P13646
IKDQERLMRHRYLDM

FSIP2

196

Q5CZC0
QAQRRDEMLRMYQAL

DNM3

721

Q9UQ16
MNLLSDARSARMYRD

CCDC88A

296

Q3V6T2
HLDQALARMREYERM

PCM1

1516

Q15154
EMVMRARDLVYHLNC

LHX2

126

P50458
EREVRMRRYRMTHSE

GDPD4

131

Q6W3E5
YMEMFQRAQALRRRA

NPIPA3

181

F8WFD2
AQRRDDMLRMYHALK

DNM2

716

P50570
PYMAAHESDARRRMI

EIF3C

696

Q99613
IPYMAAHESDARRRM

EIF3CL

696

B5ME19
MMLALVYIERLRHRN

CNPPD1

96

Q9BV87
NREMFRSVRHMIYDL

DOCK1

111

Q14185
RLMERLLDYRTIMHD

DOCK1

1176

Q14185
RVNMTYEKMSRALRH

ETV7

271

Q9Y603
LQLCMGNHELYMRRR

EZR

281

P15311
EARNLHMMLSRLDDY

FAM186A

2186

A6NE01
HYDIRMLTFIMVARL

CAND2

1121

O75155
NMLQLYASMLHERRI

DENND1B

201

Q6P3S1
AMSDAYDRTMRQRAL

PNP

161

P00491
NIIHAMIMYRRKLDR

CPT1B

276

Q92523
RQRLDLMREMYDRAA

KIF1A

806

Q12756
LRHHRMYRQNEIAMF

OSBPL3

141

Q9H4L5
IYTLRNHEMKSAMRR

OR4D10

286

Q8NGI6
YMEMFQRAQALRRRA

NPIPA7

181

E9PJI5
YMEMFQRAQALRRRA

NPIPA8

181

P0DM63
MRRMYQDARLVHADL

RIOK1

311

Q9BRS2
YMEMFQRAQALRRRA

NPIPA5

181

E9PKD4
AMDLRRRDYHMERPL

SLC26A6

21

Q9BXS9
MRASQELHDLMAARR

SPATA31A7

1066

Q8IWB4
MPRHRFMSAYEQRIE

SF3A2

146

Q15428
RRRVYDALNVLMAMN

TFDP2

181

Q14188
RRLATVHMSRMINKY

CLPTM1

186

O96005
RELMHYLREVMQDYR

NCAPD3

1221

P42695
MMALVRDRRAHYVMS

C10orf67

1

Q8IYJ2
MRASQELHDLMAARR

SPATA31A3

1066

Q5VYP0
MEYMRGLLRDNDLFR

PLEKHG5

446

O94827
RRRVYDALNVLMAMN

TFDP1

166

Q14186
SLMYYLQRLRHMLEE

UNC80

351

Q8N2C7
NRDLYRMKSRHLLDM

ZBP1

141

Q9H171
MRASQELHDLMAARR

SPATA31A1

1066

Q5TZJ5
MRASQELHDLMAARR

SPATA31A5

1066

Q5VU36
SELVRMMFNLLRRQY

RYR3

1976

Q15413
AALMYILSRDRLNMD

WAPL

721

Q7Z5K2
YEMHELLRQMGIRRI

SERPINA10

346

Q9UK55
HRTRAMQDRYMEVSG

SF3A3

41

Q12874
MRLLHELVYASRRMG

TRAPPC9

461

Q96Q05
GAALMRERDMQYVQR

ZNF622

436

Q969S3
TQYMTNRAEHDRMAR

UBE2E1

171

P51965
RHLDAAQRALYRDVM

ZNF485

26

Q8NCK3
YRHVKMCVRAEMRAR

TOR1B

281

O14657
MPRLYINRRLAMEHR

HECTD3

471

Q5T447