Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 SPPL2A ERVK-19 ERVK-25	1.54e-06	37	46	4	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 SPPL2A ERVK-19 ERVK-25	1.72e-06	38	46	4	GO:0070001
GeneOntologyMolecularFunction	N-acyltransferase activity	CERS2 CERS3 KAT6A KAT6B	8.88e-05	102	46	4	GO:0016410
GeneOntologyMolecularFunction	sphingosine N-acyltransferase activity	CERS2 CERS3	1.08e-04	7	46	2	GO:0050291
GeneOntologyMolecularFunction	histone H3K14 acetyltransferase activity	KAT6A KAT6B	1.85e-04	9	46	2	GO:0036408
GeneOntologyMolecularFunction	acyltransferase activity, transferring groups other than amino-acyl groups	CERS2 CERS3 KAT6A KAT6B SOAT2	2.12e-04	238	46	5	GO:0016747
GeneOntologyMolecularFunction	histone H3 acetyltransferase activity	KAT6A KAT6B	5.35e-04	15	46	2	GO:0010484
GeneOntologyMolecularFunction	clathrin adaptor activity	AP2A1 AP2A2	1.16e-03	22	46	2	GO:0035615
GeneOntologyMolecularFunction	cargo adaptor activity	AP2A1 AP2A2	1.51e-03	25	46	2	GO:0140312
GeneOntologyMolecularFunction	acyltransferase activity	CERS2 TRIM45 CERS3 KAT6A ASB4 KAT6B SOAT2	1.85e-03	775	46	7	GO:0016746
GeneOntologyCellularComponent	MOZ/MORF histone acetyltransferase complex	KAT6A KAT6B	1.17e-04	7	50	2	GO:0070776
GeneOntologyCellularComponent	H3 histone acetyltransferase complex	KAT6A KAT6B	1.56e-04	8	50	2	GO:0070775
GeneOntologyCellularComponent	AP-type membrane coat adaptor complex	AP2A1 AP2A2 AP5M1	2.06e-04	48	50	3	GO:0030119
GeneOntologyCellularComponent	AP-2 adaptor complex	AP2A1 AP2A2	5.01e-04	14	50	2	GO:0030122
GeneOntologyCellularComponent	clathrin coat of endocytic vesicle	AP2A1 AP2A2	5.77e-04	15	50	2	GO:0030128
GeneOntologyCellularComponent	endolysosome membrane	AP2A1 AP2A2	1.04e-03	20	50	2	GO:0036020
GeneOntologyCellularComponent	clathrin coat of coated pit	AP2A1 AP2A2	1.14e-03	21	50	2	GO:0030132
GeneOntologyCellularComponent	membrane coat	AP2A1 AP2A2 AP5M1	2.09e-03	106	50	3	GO:0030117
GeneOntologyCellularComponent	coated membrane	AP2A1 AP2A2 AP5M1	2.09e-03	106	50	3	GO:0048475
GeneOntologyCellularComponent	cytoplasmic side of membrane	SPPL2A AP2A1 AP2A2 PTPN22	2.21e-03	230	50	4	GO:0098562
GeneOntologyCellularComponent	endolysosome	AP2A1 AP2A2	2.34e-03	30	50	2	GO:0036019
GeneOntologyCellularComponent	clathrin adaptor complex	AP2A1 AP2A2	2.49e-03	31	50	2	GO:0030131
GeneOntologyCellularComponent	endosome membrane	ABCG4 SPPL2A AP2A1 AP2A2 PIGR AP5M1	3.01e-03	602	50	6	GO:0010008
Domain	-	AP2A1 AP2A2	5.68e-06	2	45	2	2.60.40.1030
Domain	AP2_complex_asu	AP2A1 AP2A2	5.68e-06	2	45	2	IPR017104
Domain	Clathrin_a-adaptin_app_sub_C	AP2A1 AP2A2	5.68e-06	2	45	2	IPR003164
Domain	Clathrin_a-adaptin_app_Ig-like	AP2A1 AP2A2	5.68e-06	2	45	2	IPR013038
Domain	Alpha_adaptin_C	AP2A1 AP2A2	5.68e-06	2	45	2	PF02296
Domain	-	AP2A1 AP2A2	3.40e-05	4	45	2	3.30.310.30
Domain	Clathrin_a/coatomer_app_sub_C	AP2A1 AP2A2	3.40e-05	4	45	2	IPR015873
Domain	MOZ_SAS	KAT6A KAT6B	5.65e-05	5	45	2	PF01853
Domain	HAT_MYST-type	KAT6A KAT6B	5.65e-05	5	45	2	IPR002717
Domain	MYST_HAT	KAT6A KAT6B	5.65e-05	5	45	2	PS51726
Domain	Lag1/Lac1	CERS2 CERS3	8.46e-05	6	45	2	IPR016439
Domain	Coatomer/calthrin_app_sub_C	AP2A1 AP2A2	1.57e-04	8	45	2	IPR009028
Domain	Clathrin_a/b/g-adaptin_app_Ig	AP2A1 AP2A2	2.02e-04	9	45	2	IPR008152
Domain	Alpha_adaptinC2	AP2A1 AP2A2	2.02e-04	9	45	2	PF02883
Domain	Alpha_adaptinC2	AP2A1 AP2A2	2.02e-04	9	45	2	SM00809
Domain	Coatomer/clathrin_app_Ig-like	AP2A1 AP2A2	3.69e-04	12	45	2	IPR013041
Domain	H15	KAT6A KAT6B	4.35e-04	13	45	2	SM00526
Domain	H15	KAT6A KAT6B	4.35e-04	13	45	2	PS51504
Domain	Histone_H1/H5_H15	KAT6A KAT6B	5.07e-04	14	45	2	IPR005818
Domain	Clathrin/coatomer_adapt-like_N	AP2A1 AP2A2	5.84e-04	15	45	2	IPR002553
Domain	Adaptin_N	AP2A1 AP2A2	5.84e-04	15	45	2	PF01602
Domain	TLC	CERS2 CERS3	6.67e-04	16	45	2	PS50922
Domain	TLC	CERS2 CERS3	6.67e-04	16	45	2	SM00724
Domain	TRAM_LAG1_CLN8	CERS2 CERS3	6.67e-04	16	45	2	PF03798
Domain	TLC-dom	CERS2 CERS3	6.67e-04	16	45	2	IPR006634
Domain	Terpenoid_cyclase/PrenylTrfase	CPAMD8 ELMO2	8.47e-04	18	45	2	IPR008930
Domain	PTPc	PTPRM PTPN22	3.39e-03	36	45	2	SM00194
Domain	TYR_PHOSPHATASE_PTP	PTPRM PTPN22	3.97e-03	39	45	2	PS50055
Domain	-	KAT6A KAT6B	4.18e-03	40	45	2	3.40.630.30
Domain	PTPase_domain	PTPRM PTPN22	4.38e-03	41	45	2	IPR000242
Domain	Y_phosphatase	PTPRM PTPN22	4.38e-03	41	45	2	PF00102
Domain	Acyl_CoA_acyltransferase	KAT6A KAT6B	5.26e-03	45	45	2	IPR016181
Domain	PTPc_motif	PTPRM PTPN22	8.90e-03	59	45	2	SM00404
Domain	Tyr_Pase_cat	PTPRM PTPN22	8.90e-03	59	45	2	IPR003595
Domain	ig	DSCAM PIGR PTPRM	1.07e-02	190	45	3	PF00047
Domain	Immunoglobulin	DSCAM PIGR PTPRM	1.07e-02	190	45	3	IPR013151
Pathway	REACTOME_LDL_CLEARANCE	AP2A1 AP2A2 SOAT2	1.22e-05	18	36	3	MM15565
Pathway	REACTOME_LDL_CLEARANCE	AP2A1 AP2A2 SOAT2	1.44e-05	19	36	3	M27846
Pathway	WP_GABA_RECEPTOR_SIGNALING	SLC6A11 AP2A1 AP2A2	6.55e-05	31	36	3	M39369
Pathway	REACTOME_PLASMA_LIPOPROTEIN_CLEARANCE	AP2A1 AP2A2 SOAT2	8.67e-05	34	36	3	MM15566
Pathway	REACTOME_PLASMA_LIPOPROTEIN_CLEARANCE	AP2A1 AP2A2 SOAT2	1.12e-04	37	36	3	M27847
Pathway	REACTOME_NEF_MEDIATED_CD8_DOWN_REGULATION	AP2A1 AP2A2	1.32e-04	7	36	2	M27044
Pathway	REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	SLC6A11 AP2A1 AP2A2 GRIN2C CHRNA5	1.85e-04	211	36	5	MM14502
Pathway	REACTOME_NEF_MEDIATED_CD4_DOWN_REGULATION	AP2A1 AP2A2	2.26e-04	9	36	2	M27011
Pathway	REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING	AP2A1 AP2A2	3.44e-04	11	36	2	MM14694
Pathway	REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD2_FZD5_AND_ROR2	AP2A1 AP2A2	4.12e-04	12	36	2	MM15163
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ABCG4 SLC6A11 AP2A1 AP2A2 GLRX3 ATP9B LRRC8D SOAT2	4.37e-04	736	36	8	M27287
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	AP2A1 AP2A2 GRIN2C CHRNA5	4.77e-04	144	36	4	MM14501
Pathway	REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD2_FZD5_AND_ROR2	AP2A1 AP2A2	4.86e-04	13	36	2	M27415
Pathway	REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE	AP2A1 AP2A2 SOAT2	5.22e-04	62	36	3	MM14686
Pathway	REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD4	AP2A1 AP2A2	5.66e-04	14	36	2	MM15161
Pathway	REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING	AP2A1 AP2A2	5.66e-04	14	36	2	M10122
Pathway	REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	SLC6A11 AP2A1 AP2A2 GRIN2C CHRNA5	5.76e-04	270	36	5	M15514
Pathway	REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD4	AP2A1 AP2A2	6.52e-04	15	36	2	M27413
Pathway	REACTOME_VLDLR_INTERNALISATION_AND_DEGRADATION	AP2A1 AP2A2	7.44e-04	16	36	2	M27761
Pathway	REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS	AP2A1 AP2A2	7.44e-04	16	36	2	MM15048
Pathway	REACTOME_VLDLR_INTERNALISATION_AND_DEGRADATION	AP2A1 AP2A2	7.44e-04	16	36	2	MM15506
Pathway	REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS	AP2A1 AP2A2	8.42e-04	17	36	2	M5488
Pathway	REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE	AP2A1 AP2A2 SOAT2	9.10e-04	75	36	3	M27032
Pathway	REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS	AP2A1 AP2A2	1.29e-03	21	36	2	M12347
Pathway	WP_SYNTHESIS_OF_CERAMIDES_AND_1DEOXYCERAMIDES	CERS2 CERS3	1.42e-03	22	36	2	M45544
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ABCG4 SLC6A11 AP2A1 AP2A2 ATP9B LRRC8D SOAT2	1.46e-03	681	36	7	MM14985
Pathway	REACTOME_NEURONAL_SYSTEM	SLC6A11 AP2A1 AP2A2 GRIN2C CHRNA5	1.51e-03	335	36	5	MM14503
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	AP2A1 AP2A2 GRIN2C CHRNA5	1.78e-03	205	36	4	M752
Pathway	WP_SPHINGOLIPID_METABOLISM_OVERVIEW	CERS2 CERS3	1.83e-03	25	36	2	MM15931
Pathway	WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY	CERS2 CERS3	1.98e-03	26	36	2	M39784
Pathway	WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY	CERS2 CERS3	1.98e-03	26	36	2	MM15892
Pathway	WP_SPHINGOLIPID_METABOLISM_OVERVIEW	CERS2 CERS3	2.14e-03	27	36	2	M39863
Pathway	REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS	CERS2 CERS3	2.14e-03	27	36	2	MM14646
Pathway	REACTOME_THE_ROLE_OF_NEF_IN_HIV_1_REPLICATION_AND_DISEASE_PATHOGENESIS	AP2A1 AP2A2	2.30e-03	28	36	2	M11362
Pathway	REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS	AP2A1 AP2A2	2.47e-03	29	36	2	MM15028
Pathway	WP_SPHINGOLIPID_PATHWAY	CERS2 CERS3	2.64e-03	30	36	2	M39501
Pathway	REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS	AP2A1 AP2A2	2.81e-03	31	36	2	M7223
Pathway	REACTOME_NEURONAL_SYSTEM	SLC6A11 AP2A1 AP2A2 GRIN2C CHRNA5	3.68e-03	411	36	5	M735
Pathway	REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS	CERS2 CERS3	3.99e-03	37	36	2	M554
Pathway	REACTOME_RECYCLING_PATHWAY_OF_L1	AP2A1 AP2A2	3.99e-03	37	36	2	MM15102
Pathway	WP_MBDNF_AND_PROBDNF_REGULATION_OF_GABA_NEUROTRANSMISSION	AP2A1 AP2A2	4.21e-03	38	36	2	M39854
Pubmed	Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins).	AP2A1 AP2A2	2.03e-06	2	50	2	2564002
Pubmed	Loss of ceramide synthase 3 causes lethal skin barrier disruption.	CERS2 CERS3	2.03e-06	2	50	2	22038835
Pubmed	ERα status of invasive ductal breast carcinoma as a result of regulatory interactions between lysine deacetylases KAT6A and KAT6B.	KAT6A KAT6B	2.03e-06	2	50	2	39505971
Pubmed	Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene.	AP2A1 AP2A2	2.03e-06	2	50	2	12036598
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	2.03e-06	2	50	2	9060628
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	2.03e-06	2	50	2	9460924
Pubmed	Regulation of KAT6 Acetyltransferases and Their Roles in Cell Cycle Progression, Stem Cell Maintenance, and Human Disease.	KAT6A KAT6B	2.03e-06	2	50	2	27185879
Pubmed	The double PHD finger domain of MOZ/MYST3 induces α-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification.	KAT6A KAT6B	2.03e-06	2	50	2	24150941
Pubmed	MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain.	KAT6A KAT6B	6.07e-06	3	50	2	36754959
Pubmed	Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses.	AP2A1 AP2A2	6.07e-06	3	50	2	35014951
Pubmed	A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2.	AP2A1 AP2A2	6.07e-06	3	50	2	18032517
Pubmed	AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.	AP2A1 AP2A2	6.07e-06	3	50	2	22262466
Pubmed	Activation of SIRT1 Enhances Epidermal Permeability Barrier Formation through Ceramide Synthase 2- and 3-Dependent Mechanisms.	CERS2 CERS3	6.07e-06	3	50	2	31958434
Pubmed	Envelope Glycoprotein Internalization Protects Human and Simian Immunodeficiency Virus-Infected Cells from Antibody-Dependent Cell-Mediated Cytotoxicity.	AP2A1 AP2A2	6.07e-06	3	50	2	26269175
Pubmed	Tandem PHD fingers of MORF/MOZ acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatin.	KAT6A KAT6B	6.07e-06	3	50	2	23063713
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-19	6.07e-06	3	50	2	10516026
Pubmed	The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein.	AP2A1 AP2A2	6.07e-06	3	50	2	8662627
Pubmed	A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex.	AP2A1 AP2A2	6.07e-06	3	50	2	19129443
Pubmed	Interaction of Shc with adaptor protein adaptins.	AP2A1 AP2A2	6.07e-06	3	50	2	8617812
Pubmed	The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction.	AP2A1 AP2A2	1.21e-05	4	50	2	12646615
Pubmed	Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF).	KAT6A KAT6B	1.21e-05	4	50	2	21880731
Pubmed	The interaction of ETV6 (TEL) and TIP60 requires a functional histone acetyltransferase domain in TIP60.	KAT6A KAT6B	1.21e-05	4	50	2	17980166
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-19	1.21e-05	4	50	2	7983737
Pubmed	Disruption of the murine Ap2β1 gene causes nonsyndromic cleft palate.	AP2A1 AP2A2	1.21e-05	4	50	2	20500056
Pubmed	Association and colocalization of Eps15 with adaptor protein-2 and clathrin.	AP2A1 AP2A2	1.21e-05	4	50	2	9049247
Pubmed	Posttranslational acetylation of the human immunodeficiency virus type 1 integrase carboxyl-terminal domain is dispensable for viral replication.	KAT6A KAT6B	2.02e-05	5	50	2	17182677
Pubmed	Weak Molecular Interactions in Clathrin-Mediated Endocytosis.	AP2A1 AP2A2	2.02e-05	5	50	2	29184887
Pubmed	MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2.	KAT6A KAT6B	2.02e-05	5	50	2	11965546
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-19	2.02e-05	5	50	2	12629516
Pubmed	A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein.	AP2A1 AP2A2	2.02e-05	5	50	2	17108326
Pubmed	Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2.	AP2A1 AP2A2	2.02e-05	5	50	2	16139856
Pubmed	Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations.	AP2A1 AP2A2	2.02e-05	5	50	2	31671891
Pubmed	Analysis of the AP-2 adaptor complex and cargo during clathrin-mediated endocytosis.	AP2A1 AP2A2	2.02e-05	5	50	2	15941406
Pubmed	Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis.	AP2A1 AP2A2	2.02e-05	5	50	2	9723620
Pubmed	Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.	CERS2 CERS3	2.02e-05	5	50	2	26887952
Pubmed	Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes.	AP2A1 AP2A2	3.03e-05	6	50	2	22650988
Pubmed	The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sites.	AP2A1 AP2A2	3.03e-05	6	50	2	12121421
Pubmed	Clathrin.	AP2A1 AP2A2	3.03e-05	6	50	2	10966473
Pubmed	Numb expression and asymmetric versus symmetric cell division in distal embryonic lung epithelium.	AP2A1 AP2A2	3.03e-05	6	50	2	22713487
Pubmed	Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.	CERS2 CERS3	3.03e-05	6	50	2	17977534
Pubmed	Molecular architecture and functional model of the endocytic AP2 complex.	AP2A1 AP2A2	3.03e-05	6	50	2	12086608
Pubmed	HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses.	AP2A1 AP2A2	3.03e-05	6	50	2	15020715
Pubmed	Oxidized phospholipids induce ceramide accumulation in RAW 264.7 macrophages: role of ceramide synthases.	CERS2 CERS3	3.03e-05	6	50	2	23936132
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-19	3.03e-05	6	50	2	15063128
Pubmed	Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.	KAT6A KAT6B	4.23e-05	7	50	2	18794358
Pubmed	Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine.	AP2A1 AP2A2	4.23e-05	7	50	2	20351096
Pubmed	Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta.	AP2A1 AP2A2	4.23e-05	7	50	2	16103193
Pubmed	Clathrin interacts specifically with amphiphysin and is displaced by dynamin.	AP2A1 AP2A2	4.23e-05	7	50	2	9280305
Pubmed	Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein.	AP2A1 AP2A2	4.23e-05	7	50	2	7671305
Pubmed	Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.	AP2A1 AP2A2	4.23e-05	7	50	2	23676497
Pubmed	Serine phosphorylation-independent downregulation of cell-surface CD4 by nef.	AP2A1 AP2A2	5.64e-05	8	50	2	2014052
Pubmed	Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice.	AP2A1 AP2A2	5.64e-05	8	50	2	11879655
Pubmed	Accessory protein recruitment motifs in clathrin-mediated endocytosis.	AP2A1 AP2A2	7.25e-05	9	50	2	12057195
Pubmed	Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous system.	AP2A1 AP2A2	7.25e-05	9	50	2	11591131
Pubmed	WDFY4 is required for cross-presentation in response to viral and tumor antigens.	CERS2 AP2A1 AP2A2 TRAPPC8	7.64e-05	156	50	4	30409884
Pubmed	CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.	AP2A1 AP2A2	9.05e-05	10	50	2	25898166
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-19	9.05e-05	10	50	2	12970426
Pubmed	HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2.	AP2A1 AP2A2	9.05e-05	10	50	2	17581864
Pubmed	Haploinsufficiency in the ANKS1B gene encoding AIDA-1 leads to a neurodevelopmental syndrome.	AP2A1 AP2A2	1.10e-04	11	50	2	31388001
Pubmed	Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.	CERS2 CERS3	1.10e-04	11	50	2	23689133
Pubmed	HIV-1 Assembly at the Plasma Membrane: Gag Trafficking and Localization.	AP2A1 AP2A2	1.10e-04	11	50	2	19802344
Pubmed	Acetylation of HIV-1 integrase by p300 regulates viral integration.	KAT6A KAT6B	1.10e-04	11	50	2	16096645
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-19	1.32e-04	12	50	2	14557543
Pubmed	Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins.	AP2A1 AP2A2	1.56e-04	13	50	2	9882340
Pubmed	Redundant and nonredundant organismal functions of EPS15 and EPS15L1.	AP2A1 AP2A2	1.82e-04	14	50	2	30692166
Pubmed	Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor.	AP2A1 AP2A2	1.82e-04	14	50	2	11157096
Pubmed	APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development.	AP2A1 AP2A2	1.82e-04	14	50	2	29262337
Pubmed	LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.	AP2A1 AP2A2	2.10e-04	15	50	2	21307259
Pubmed	Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance.	AP2A1 AP2A2	2.40e-04	16	50	2	24305805
Pubmed	HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation.	AP2A1 AP2A2	2.40e-04	16	50	2	21762802
Pubmed	PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking.	AP2A1 AP2A2	2.40e-04	16	50	2	16055064
Pubmed	Characterization of 16 novel human genes showing high similarity to yeast sequences.	GLRX3 ATP9B	2.72e-04	17	50	2	11124703
Pubmed	The frantic play of the concealed HIV envelope cytoplasmic tail.	AP2A1 AP2A2	3.05e-04	18	50	2	23705972
Pubmed	The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module.	AP2A1 AP2A2	3.05e-04	18	50	2	10567358
Pubmed	Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb.	AP2A1 AP2A2	3.05e-04	18	50	2	23211419
Pubmed	Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation.	AP2A1 AP2A2	3.41e-04	19	50	2	31959764
Pubmed	PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier.	CERS2 CERS3	3.41e-04	19	50	2	28369476
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-19 ERVK-25	3.42e-04	94	50	3	21542922
Pubmed	Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.	AP2A1 AP2A2	4.59e-04	22	50	2	26950368
Pubmed	Human immunodeficiency virus type-1 gag and host vesicular trafficking pathways.	AP2A1 AP2A2	5.48e-04	24	50	2	20012524
Pubmed	Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins.	AP2A1 AP2A2	5.95e-04	25	50	2	20594957
Pubmed	Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.	AP2A1 AP2A2	6.44e-04	26	50	2	24067654
Pubmed	The tale of the long tail: the cytoplasmic domain of HIV-1 gp41.	AP2A1 AP2A2	6.44e-04	26	50	2	23077317
Pubmed	Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.	CERS2 CERS3	6.95e-04	27	50	2	23096701
Pubmed	Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.	CERS2 CERS3	6.95e-04	27	50	2	25269881
Pubmed	The AP-3 complex: a coat of many colours.	AP2A1 AP2A2	7.48e-04	28	50	2	9714600
Pubmed	The essential player in adipogenesis GRP78 is a novel KCTD15 interactor.	AP2A1 AP2A2	8.02e-04	29	50	2	29665387
Pubmed	Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.	CERS2 CERS3	8.02e-04	29	50	2	38485951
Pubmed	A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells.	GRIN2C CHN1	8.59e-04	30	50	2	31065682
Pubmed	Use of comparative physical and sequence mapping to annotate mouse chromosome 16 and human chromosome 21.	PIGP DSCAM	8.59e-04	30	50	2	11374901
Pubmed	FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis.	AP2A1 AP2A2	9.17e-04	31	50	2	22323290
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	ST6GAL2 GLRX3 KAT6A GBGT1	1.07e-03	313	50	4	20800603
Pubmed	Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.	SPPL2A CHD9	1.17e-03	35	50	2	23969696
Pubmed	Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.	SPPL2A AP2A2	1.31e-03	37	50	2	24162737
Cytoband	21q22.2	PIGP DSCAM	5.77e-04	33	49	2	21q22.2
GeneFamily	CERS class homeoboxes	CERS2 CERS3	4.53e-05	6	32	2	530
GeneFamily	Zinc fingers C2HC-type\|PHD finger proteins\|Lysine acetyltransferases	KAT6A KAT6B	3.59e-04	16	32	2	66
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	KAT6A KAT6B	4.06e-04	17	32	2	486
GeneFamily	PHD finger proteins	KAT6A KAT6B	1.10e-02	90	32	2	88
Coexpression	GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_3H_DN	ST6GAL2 PIGP MIGA1 PTPN22 CHN1	8.23e-06	161	45	5	M8250
Disease	cysteine-rich with EGF-like domain protein 1 measurement	SLC6A11 JAGN1	1.05e-03	32	44	2	EFO_0021870
Disease	retinal detachment, retinal break	CPAMD8 LAMA2	1.25e-03	35	44	2	EFO_0005773, EFO_0010698
Disease	pulmonary function measurement, forced expiratory volume	SLC6A11 CHRNA5	1.40e-03	37	44	2	EFO_0003892, EFO_0004314
Disease	Alzheimer disease, peptic ulcer disease	AP2A2 DSCAM	1.55e-03	39	44	2	MONDO_0004247, MONDO_0004975
Disease	fibrinogen measurement, tissue plasminogen activator measurement	SPPL2A CHD9	2.07e-03	45	44	2	EFO_0004623, EFO_0004791
Disease	Ischemic stroke, fibrinogen measurement	SPPL2A CHD9	3.07e-03	55	44	2	EFO_0004623, HP_0002140
Disease	creatinine measurement	CERS2 SPPL2A DSCAM LAMA2 CHD9 ATP9B	3.42e-03	995	44	6	EFO_0004518
Disease	rheumatoid arthritis, COVID-19	GBGT1 MIGA1	4.13e-03	64	44	2	EFO_0000685, MONDO_0100096
Disease	venous thromboembolism, fibrinogen measurement	SPPL2A CHD9	4.52e-03	67	44	2	EFO_0004286, EFO_0004623
Disease	temporal horn of lateral ventricle volume measurement	PTPRM GLRX3	5.20e-03	72	44	2	EFO_0010333
Disease	response to alcohol	SLC6A11 LAMA2	5.63e-03	75	44	2	EFO_0005526
Disease	non-small cell lung carcinoma	DSCAM CHRNA5	5.63e-03	75	44	2	EFO_0003060

Protein segments in the cluster

Peptide	Gene	Start	Entry
KTIPTYLQWSSYLSY	ABCG4	556	Q9H172
EKNLYPTVYTLWSYP	EIF2D	76	P41214
YTYWAYVPFPPLIRA	ERVK-19	101	O71037
ISYSYYPQFWISPSL	CPED1	816	A4D0V7
VLASYKQGYWLPSYK	ASB4	56	Q9Y574
DYTYYFVPAPWLSVK	AP2A1	246	O95782
KWTYPKNATTQYYPR	DNAI3	246	Q8IWG1
PIQSTIPSQYWYYMI	CERS2	171	Q96G23
DYTYYFVPAPWLSVK	AP2A2	246	O94973
IHYPRYSLYWSKSDP	CFAP91	81	Q7Z4T9
NWAPPEYYLYSTTSQ	RBM46	406	Q8TBY0
YSYIPLVENPYFSSW	PTPN22	526	Q9Y2R2
QTWYSSPYPQEYARL	KAT6B	731	Q8WYB5
TYRIYWYQQKPGSLP	IGLV5-39	51	A0A0G2JS06
PYQWEYPYLLSILPS	JAGN1	71	Q8N5M9
LKAYSSWPTYPQLYV	GLRX3	191	O76003
VPALKIGYLYTYWAP	ATP9B	171	O43861
CYHPEVIKYTYSKPW	OR51T1	181	Q8NGJ9
SYYWSAPAPYLGNKL	LAMA2	581	P24043
DYYIWNSKAPAPVTY	AP5M1	471	Q9H0R1
KYEIHTWYSSPYPQE	KAT6A	516	Q92794
TWYSSPYPQEYSRLP	KAT6A	521	Q92794
WYPYVTYSFVIKRLP	CHRNA5	236	P30532
EPVIYYLVKWCSLPY	CHD9	791	Q3L8U1
KQPLLPSQYWYYILE	CERS3	171	Q8IU89
QWTLYSLTPLYKFSY	CENPL	71	Q8N0S6
YLENWLPVSYVPYYL	GBGT1	26	Q8N5D6
YTYWAYVPFPPLIRA	ERVK-25	101	P61570
YTYWAYVPFPPLIRA	ERVK-6	101	Q69384
WSLPNPEYYTLRYAD	ELMO2	41	Q96JJ3
QYLPSYLSLGSWYSP	CPAMD8	436	Q8IZJ3
TYLYWYLQKPGQSPQ	IGKV2-29	56	A2NJV5
YTYWAYVPFPPLIRA	HERVK_113	101	Q902F9
YRPPVWKSYLYQLQQ	CHN1	11	P15882
WIYSMLYNSKPSLYS	DSEL	1036	Q8IZU8
TYWPQKYWAVALPVY	PIGP	71	P57054
LALPWYSKYFPYLAL	LRRC8D	156	Q7L1W4
GYWNTPLLPYKSYRI	PTPRM	686	P28827
PLTWYYSLSQIKFSP	MIGA1	56	Q8NAN2
PYYSIKWYKNSNLLP	DSCAM	531	O60469
YISYTPKEPGVYTVW	TRIM45	466	Q9H8W5
LWYKKPDYNLFTPYI	ST6GAL2	381	Q96JF0
YPRTPYVRWNYVAKN	SOAT2	286	O75908
YCMLYNPYWTALPST	SPPL2A	41	Q8TCT8
KPLKYNNIYTYPAWG	SLC6A11	536	P48066
YYPPTSVNRHTRKYW	PIGR	41	P01833
TYYLFWYKQPPSGEL	TRAV19	51	A0A0A6YYK7
YWVTLRKPSPVYSFG	SLC30A6	81	Q6NXT4
FYQYLYPWQSGKVLP	XKR3	396	Q5GH77
YPKWFIPNTLKYYVL	TRAPPC8	181	Q9Y2L5
GHPNVYKSSWLYPVY	TMEM236	256	Q5W0B7
YMKYPVWPRYSASLQ	GRIN2C	381	Q14957