Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytoskeletal protein binding	VPS18 DST TRAF3IP1 SYNE1 SPTA1 SYNE2 LMTK2 TLN2 INO80 KIF13A SHANK3 HSP90AA1 DRG1	1.50e-05	1099	59	13	GO:0008092
GeneOntologyMolecularFunction	actin binding	VPS18 DST SYNE1 SPTA1 SYNE2 TLN2 INO80 SHANK3	7.84e-05	479	59	8	GO:0003779
GeneOntologyMolecularFunction	cytoskeleton-nuclear membrane anchor activity	SYNE1 SYNE2	8.53e-05	5	59	2	GO:0140444
GeneOntologyMolecularFunction	ATP hydrolysis activity	MDN1 INO80 KIF13A ATP10A HSP90AA1 HSP90AA2P DNAH11	3.10e-04	441	59	7	GO:0016887
GeneOntologyMolecularFunction	protein serine kinase activity	HIPK3 SLK NEK10 MAPKAPK3 LMTK2 PNCK	6.93e-04	363	59	6	GO:0106310
GeneOntologyCellularComponent	microtubule organizing center attachment site	SYNE1 SYNE2	4.53e-04	11	61	2	GO:0034992
GeneOntologyCellularComponent	meiotic nuclear membrane microtubule tethering complex	SYNE1 SYNE2	4.53e-04	11	61	2	GO:0034993
GeneOntologyCellularComponent	nuclear membrane protein complex	SYNE1 SYNE2	4.53e-04	11	61	2	GO:0106083
GeneOntologyCellularComponent	nuclear membrane microtubule tethering complex	SYNE1 SYNE2	4.53e-04	11	61	2	GO:0106094
Domain	Spectrin	DST SYNE1 SPTA1 SYNE2	7.09e-07	23	58	4	PF00435
Domain	Spectrin_repeat	DST SYNE1 SPTA1 SYNE2	1.88e-06	29	58	4	IPR002017
Domain	Spectrin/alpha-actinin	DST SYNE1 SPTA1 SYNE2	2.82e-06	32	58	4	IPR018159
Domain	SPEC	DST SYNE1 SPTA1 SYNE2	2.82e-06	32	58	4	SM00150
Domain	Actinin_actin-bd_CS	DST SYNE1 SYNE2	4.82e-05	23	58	3	IPR001589
Domain	ACTININ_2	DST SYNE1 SYNE2	4.82e-05	23	58	3	PS00020
Domain	ACTININ_1	DST SYNE1 SYNE2	4.82e-05	23	58	3	PS00019
Domain	KASH	SYNE1 SYNE2	5.66e-05	4	58	2	PF10541
Domain	KASH	SYNE1 SYNE2	5.66e-05	4	58	2	IPR012315
Domain	FERM_f0	TLN2 SHANK3	5.66e-05	4	58	2	IPR032425
Domain	KASH	SYNE1 SYNE2	5.66e-05	4	58	2	PS51049
Domain	FERM_f0	TLN2 SHANK3	5.66e-05	4	58	2	PF16511
Domain	KASH	SYNE1 SYNE2	5.66e-05	4	58	2	SM01249
Domain	Protein_kinase_ATP_BS	TYK2 HIPK3 SLK NEK10 MAPKAPK3 LMTK2 PNCK	1.65e-04	379	58	7	IPR017441
Domain	Kinase-like_dom	TYK2 HIPK3 SLK DST NEK10 MAPKAPK3 LMTK2 PNCK	2.55e-04	542	58	8	IPR011009
Domain	PROTEIN_KINASE_ATP	TYK2 HIPK3 SLK NEK10 MAPKAPK3 LMTK2 PNCK	5.27e-04	459	58	7	PS00107
Domain	Prot_kinase_dom	TYK2 HIPK3 SLK NEK10 MAPKAPK3 LMTK2 PNCK	7.66e-04	489	58	7	IPR000719
Domain	PROTEIN_KINASE_DOM	TYK2 HIPK3 SLK NEK10 MAPKAPK3 LMTK2 PNCK	8.03e-04	493	58	7	PS50011
Domain	ATPase_dyneun-rel_AAA	MDN1 DNAH11	8.42e-04	14	58	2	IPR011704
Domain	AAA_5	MDN1 DNAH11	8.42e-04	14	58	2	PF07728
Domain	CH	DST SYNE1 SYNE2	1.08e-03	65	58	3	SM00033
Domain	CH	DST SYNE1 SYNE2	1.34e-03	70	58	3	PF00307
Domain	-	DST SYNE1 SYNE2	1.40e-03	71	58	3	1.10.418.10
Domain	CH	DST SYNE1 SYNE2	1.52e-03	73	58	3	PS50021
Domain	CH-domain	DST SYNE1 SYNE2	1.64e-03	75	58	3	IPR001715
Domain	SAM	STIM2 L3MBTL1 SHANK3	2.59e-03	88	58	3	SM00454
Domain	SAM_DOMAIN	STIM2 L3MBTL1 SHANK3	3.21e-03	95	58	3	PS50105
Domain	PROTEIN_KINASE_TYR	TYK2 NEK10 LMTK2	3.41e-03	97	58	3	PS00109
Domain	SAM	STIM2 L3MBTL1 SHANK3	3.41e-03	97	58	3	IPR001660
Domain	Tyr_kinase_AS	TYK2 NEK10 LMTK2	3.41e-03	97	58	3	IPR008266
Domain	-	STIM2 L3MBTL1 SHANK3	4.37e-03	106	58	3	1.10.150.50
Domain	SH3	DST SPTA1 UBASH3A SHANK3	4.53e-03	216	58	4	PS50002
Domain	SH3_domain	DST SPTA1 UBASH3A SHANK3	4.83e-03	220	58	4	IPR001452
Domain	S_TKc	HIPK3 SLK NEK10 MAPKAPK3 PNCK	5.08e-03	359	58	5	SM00220
Domain	SAM/pointed	STIM2 L3MBTL1 SHANK3	5.75e-03	117	58	3	IPR013761
Domain	Pkinase	HIPK3 SLK NEK10 MAPKAPK3 PNCK	6.50e-03	381	58	5	PF00069
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SLK MDN1 DST TRAF3IP1 OSBPL3 SYNE1 SYNE2 TLN2 TEX10 SHANK3 HSP90AA1	8.18e-07	963	61	11	28671696
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DST STXBP1 STAG1 TRAF3IP1 SYNE1 FIP1L1 TLN2 TMEM222 UBASH3A RSBN1L HSP90AA1 DMAP1	2.01e-06	1285	61	12	35914814
Pubmed	Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.	SYNE1 SYNE2	3.03e-06	2	61	2	22768332
Pubmed	Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.	SYNE1 SYNE2	3.03e-06	2	61	2	11792814
Pubmed	Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.	SYNE1 SYNE2	3.03e-06	2	61	2	24931616
Pubmed	Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.	SYNE1 SYNE2	3.03e-06	2	61	2	17267447
Pubmed	Nesprins: tissue-specific expression of epsilon and other short isoforms.	SYNE1 SYNE2	3.03e-06	2	61	2	24718612
Pubmed	Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.	SYNE1 SYNE2	3.03e-06	2	61	2	24586179
Pubmed	Cloning and analysis of a human 86-kDa heat-shock-protein-encoding gene.	HSP90AA1 HSP90AA2P	3.03e-06	2	61	2	2591742
Pubmed	Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.	SYNE1 SYNE2	3.03e-06	2	61	2	17761684
Pubmed	Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.	SYNE1 SYNE2	3.03e-06	2	61	2	31578382
Pubmed	A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease.	STXBP1 SPTA1 HSP90AA1	4.11e-06	18	61	3	16049941
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	RIN1 DPP6 VPS18 SLK DST STXBP1 SYNE1 SPTA1 TLN2 SHANK3 HSP90AA1 DNAH11	6.04e-06	1431	61	12	37142655
Pubmed	Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.	SYNE1 SYNE2	9.07e-06	3	61	2	10878022
Pubmed	The regulatory mechanism of extracellular Hsp90{alpha} on matrix metalloproteinase-2 processing and tumor angiogenesis.	HSP90AA1 HSP90AA2P	9.07e-06	3	61	2	20937816
Pubmed	The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.	SYNE1 SYNE2	9.07e-06	3	61	2	16079285
Pubmed	The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.	SYNE1 SYNE2	9.07e-06	3	61	2	12408964
Pubmed	Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness.	HSP90AA1 HSP90AA2P	9.07e-06	3	61	2	15146192
Pubmed	Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.	SYNE1 SYNE2	9.07e-06	3	61	2	17462627
Pubmed	Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.	SYNE1 SYNE2	9.07e-06	3	61	2	33472039
Pubmed	Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.	SYNE1 SYNE2	9.07e-06	3	61	2	25516977
Pubmed	The levels of retinoic acid-inducible gene I are regulated by heat shock protein 90-alpha.	HSP90AA1 HSP90AA2P	1.81e-05	4	61	2	19234166
Pubmed	SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.	SYNE1 SYNE2	1.81e-05	4	61	2	16648470
Pubmed	Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14.	HSP90AA1 HSP90AA2P	1.81e-05	4	61	2	1740332
Pubmed	LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina.	SYNE1 SYNE2	1.81e-05	4	61	2	23071752
Pubmed	Cloning, expression analysis, and chromosomal localization of murine and human homologues of a Xenopus mix gene.	TGFB2 SPTA1	1.81e-05	4	61	2	11084649
Pubmed	Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.	SYNE1 SYNE2	1.81e-05	4	61	2	20108321
Pubmed	Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase.	HSP90AA1 HSP90AA2P	1.81e-05	4	61	2	23589305
Pubmed	Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.	SYNE1 SYNE2	1.81e-05	4	61	2	19596800
Pubmed	Novel murine homeo box gene on chromosome 1 expressed in specific hematopoietic lineages and during embryogenesis.	TGFB2 SPTA1	1.81e-05	4	61	2	1672660
Pubmed	Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.	SYNE1 SYNE2	1.81e-05	4	61	2	28716842
Pubmed	Early expression of hepatocyte growth factor, interleukin-6, and transforming growth factor-beta1 and -beta2 in symptomatic infection in patients who have undergone liver transplantation.	TGFB2 HGF	1.81e-05	4	61	2	19249525
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	STIM2 MDN1 DST PHF3 OSBPL3 SYNE2 LMTK2 FIP1L1 KIF13A	1.84e-05	861	61	9	36931259
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	DST SYNE1 SPTA1 SYNE2 HSP90AA1	1.99e-05	187	61	5	26460568
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	STIM2 DST STAG1 SYNE2	2.13e-05	92	61	4	15840729
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	DST SYNE1 SYNE2 MCCC2 RSBN1L	2.55e-05	197	61	5	20811636
Pubmed	Molecular cloning and chromosomal mapping of the mouse cyclin-dependent kinase 5 gene.	HGF DPP6	3.02e-05	5	61	2	7490100
Pubmed	Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.	SYNE1 SYNE2	3.02e-05	5	61	2	18396275
Pubmed	LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.	SYNE1 SYNE2	3.02e-05	5	61	2	22632968
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	STIM2 MDN1 DST STXBP1 STAG1 KIAA0825 SYNE1 SPTA1 SYNE2 TEX10 HSP90AA1	3.72e-05	1442	61	11	35575683
Pubmed	A high-resolution genetic map of mouse chromosome 5 encompassing the reeler (rl) locus.	HGF DPP6	4.52e-05	6	61	2	7851897
Pubmed	Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.	SYNE1 SYNE2	4.52e-05	6	61	2	33058875
Pubmed	TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.	SYNE1 SYNE2	4.52e-05	6	61	2	18827015
Pubmed	Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32.	TGFB2 SPTA1	4.52e-05	6	61	2	9177772
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	DST PHF3 SYNE1 SYNE2 TLN2	4.80e-05	225	61	5	12168954
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	MDN1 PHF3 FIP1L1 MCCC2 TEX10 RSBN1L TXNDC12 HSP90AA1 DMAP1	5.40e-05	989	61	9	36424410
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	DST PHF3 SYNE1 SHANK3 DNAH11	5.67e-05	233	61	5	37704626
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	MDN1 DST SYNE1 LTV1 KIF13A	5.78e-05	234	61	5	36243803
Pubmed	The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex.	MDN1 TEX10	6.32e-05	7	61	2	21326211
Pubmed	Epithelial-mesenchymal transition and its implications for fibrosis.	TGFB2 HGF	6.32e-05	7	61	2	14679171
Pubmed	Vti1b promotes TRPV1 sensitization during inflammatory pain.	DST OSBPL3 TXNDC12 HSP90AA1	7.53e-05	127	61	4	30335684
Pubmed	Functional proteomics mapping of a human signaling pathway.	HIPK3 STIM2 DST STAG1 TEX10 KIF13A ST6GALNAC2	7.79e-05	591	61	7	15231748
Pubmed	Identification of the switch in early-to-late endosome transition.	VPS18 MON1A	8.42e-05	8	61	2	20434987
Pubmed	The glucocorticoid-glucocorticoid receptor signal transduction pathway, transforming growth factor-beta, and embryonic mouse lung development in vivo.	TGFB2 HSP90AA1	8.42e-05	8	61	2	8726224
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	SPTA1 MCCC2 UBASH3A HSP90AA1 DRG1	1.06e-04	266	61	5	19380743
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	MDN1 PHF3 OSBPL3 FIP1L1 INO80 TEX10 HSP90AA1 DMAP1	1.13e-04	847	61	8	35850772
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	PHF3 LMTK2 FIP1L1 TEX10 DMAP1 DRG1	1.22e-04	440	61	6	34244565
Pubmed	The DNA sequence of human chromosome 7.	HGF DPP6 OSBPL3 LMTK2 LRRC17 DNAH11	1.24e-04	441	61	6	12853948
Pubmed	Nuclear membrane proteins with potential disease links found by subtractive proteomics.	SYNE1 SYNE2	1.35e-04	10	61	2	12958361
Pubmed	Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle.	SYNE1 SYNE2	1.35e-04	10	61	2	28533284
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	STXBP1 PHF3 SYNE1 TLN2 SHANK3	1.37e-04	281	61	5	28706196
Pubmed	The functional interactome landscape of the human histone deacetylase family.	MDN1 STAG1 SYNE2 FIP1L1 MCCC2	1.56e-04	289	61	5	23752268
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	STIM2 STXBP1 LMTK2 TLN2 AASDHPPT MCCC2 SHANK3 TXNDC12 HSP90AA1	1.58e-04	1139	61	9	36417873
Pubmed	Evolutionary diversification of the BetaM interactome acquired through co-option of the ATP1B4 gene in placental mammals.	PHF3 SYNE1	1.65e-04	11	61	2	26939788
Pubmed	A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.	SYNE1 SYNE2	1.65e-04	11	61	2	22826121
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	HIPK3 VPS18 STIM2 SLK DST MCCC2 TEX10 UBASH3A	1.84e-04	910	61	8	36736316
Pubmed	Characterization of the Cullin7 E3 ubiquitin ligase--heterodimerization of cullin substrate receptors as a novel mechanism to regulate cullin E3 ligase activity.	FBXO4 HSP90AA1	1.97e-04	12	61	2	21946088
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	MDN1 PHF3 OSBPL3 CCDC25 MCCC2 SHANK3 DNAH11	2.00e-04	689	61	7	36543142
Pubmed	KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.	SYNE1 SYNE2	2.33e-04	13	61	2	21177258
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	DST STAG1 SYNE2 TLN2 TEX10 DRG1	2.38e-04	498	61	6	36634849
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	RIN1 PHF3 FIP1L1 TLN2 KIF13A DMAP1	2.52e-04	503	61	6	16964243
Pubmed	SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.	SYNE1 SYNE2	2.72e-04	14	61	2	19874786
Pubmed	PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78.	HSP90AA1 HSP90AA2P	2.72e-04	14	61	2	29178343
Pubmed	Identification of potential protein interactors of Lrrk2.	MDN1 HSP90AA1	3.13e-04	15	61	2	17400507
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	HIPK3 AFMID STAG1 OSBPL3 MAPKAPK3 TLN2	3.53e-04	536	61	6	15840001
Pubmed	The HSP90 family of genes in the human genome: insights into their divergence and evolution.	HSP90AA1 HSP90AA2P	3.57e-04	16	61	2	16269234
Pubmed	The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis.	TGFB2 HGF	3.57e-04	16	61	2	36227576
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	HIPK3 AFMID STAG1 OSBPL3 MAPKAPK3 TLN2	3.60e-04	538	61	6	10512203
Pubmed	Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.	STIM2 SLK DST SYNE2	3.60e-04	191	61	4	31177093
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	MDN1 DST PHF3 OSBPL3 SPTA1 FIP1L1 MCCC2 INO80 DMAP1	4.04e-04	1294	61	9	30804502
Pubmed	A role for p75 neurotrophin receptor in the control of hair follicle morphogenesis.	TGFB2 HGF	4.05e-04	17	61	2	10588868
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	SLK DST SYNE2 MAPKAPK3 MCCC2 TXNDC12 HSP90AA1 DMAP1 DRG1	4.11e-04	1297	61	9	33545068
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	PHF3 MAPKAPK3 FIP1L1 TLN2 ATP10A	4.33e-04	361	61	5	26167880
Pubmed	TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts.	TGFB2 HGF	4.55e-04	18	61	2	23041440
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	SPTA1 TLN2	4.55e-04	18	61	2	12119179
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	STIM2 SLK DST SYNE2 CCDC25 HSP90AA1	4.79e-04	568	61	6	37774976
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	MDN1 STAG1 FIP1L1 TLN2 HSP90AA1 DRG1	5.45e-04	582	61	6	20467437
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	DST SYNE1	5.63e-04	20	61	2	21689717
Pubmed	The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation.	TGFB2 HGF	5.63e-04	20	61	2	9203584
Pubmed	UBASH3A Regulates the Synthesis and Dynamics of TCR-CD3 Complexes.	UBASH3A HSP90AA1	5.63e-04	20	61	2	31659016
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DST SYNE1 FIP1L1 INO80 TEX10 HSP90AA1 DMAP1 DRG1	5.84e-04	1082	61	8	38697112
Pubmed	SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.	MDN1 TEX10	6.22e-04	21	61	2	37014752
Pubmed	Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci.	TGFB2 SPTA1	6.22e-04	21	61	2	1970330
Pubmed	An Alternative Splicing Program for Mouse Craniofacial Development.	SLK SYNE2	6.22e-04	21	61	2	33013468
Pubmed	DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.	TRAF3IP1 SYNE1	6.83e-04	22	61	2	12812986
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	SLK MDN1 TLN2 AASDHPPT LTV1 HSP90AA1 HSP90AA2P	6.90e-04	847	61	7	35235311
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	MDN1 STAG1 MAPKAPK3 FIP1L1 TEX10 HSP90AA1 DMAP1	7.39e-04	857	61	7	25609649
Pubmed	Murine chromosomal location of five bHLH-Zip transcription factor genes.	TGFB2 SPTA1	8.15e-04	24	61	2	8530024
Pubmed	Human transcription factor protein interaction networks.	SLK DST SYNE2 FIP1L1 LTV1 MCCC2 INO80 TEX10 DMAP1	8.22e-04	1429	61	9	35140242
Pubmed	Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.	SYNE1 PIMREG	8.84e-04	25	61	2	38877142
Interaction	PRNP interactions	DPP6 MDN1 STXBP1 PHF3 OSBPL3 TLN2 PIMREG CCDC25 AASDHPPT MCCC2 SHANK3 TXNDC12 HSP90AA1 DNAH11	5.70e-06	1158	60	14	int:PRNP
Interaction	TRAF3IP1 interactions	DST TRAF3IP1 SHANK3 HSP90AA1 DMAP1	9.80e-06	96	60	5	int:TRAF3IP1
Interaction	YWHAG interactions	HGF RIN1 STIM2 SLK MDN1 DST PHF3 OSBPL3 SYNE2 LMTK2 FIP1L1 KIF13A SHANK3 HSP90AA1	1.34e-05	1248	60	14	int:YWHAG
GeneFamily	Spectrin repeat containing nuclear envelope family	SYNE1 SYNE2	2.44e-05	4	37	2	1252
GeneFamily	Sterile alpha motif domain containing	STIM2 L3MBTL1 SHANK3	7.68e-04	88	37	3	760
Coexpression	LAKE_ADULT_KIDNEY_C2_PODOCYTES	CCDC91 DPP6 SLK DST KIF13A ATP10A	1.00e-05	212	61	6	M39221
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KIAA0825 NEK10 OSBPL3 SYNE1 SYNE2 DNAH11	2.69e-07	197	60	6	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F_2\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PHF3 SYNE1 SYNE2 FIP1L1 HSP90AA1	6.70e-06	196	60	5	ea8eceacc5d5e1a22b77c31e7c45985dc7bb15de
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	HGF DST SYNE1 CREB3L1 LRRC17	7.39e-06	200	60	5	bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Pvrl3\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TGFB2 HGF STIM2 UBASH3A	2.61e-05	127	60	4	9bc55cb9f4bddb274930784d12a83b9dceb35cb7
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC91 DPP6 DST ATP10A	7.77e-05	168	60	4	e96859dbf51cf8c4def8ee8db132f4d874fb4381
ToppCell	NS-critical-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FBXO4 TRAF3IP1 NEK10 DNAH11	9.30e-05	176	60	4	b794275fdd757b8fa2108e3c867f23da2649146d
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	MDN1 DST SYNE1 KIF13A	9.51e-05	177	60	4	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAG1 SYNE1 SYNE2 HSP90AA1	9.72e-05	178	60	4	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC91 DPP6 DST ATP10A	9.93e-05	179	60	4	7394e77e665bf16d3733df91bb12907be460ab44
ToppCell	IIH-CD8-CD4_Treg\|IIH / Condition, Cell_class and T cell subcluster	OSBPL3 LMTK2 MCCC2 ATP10A	1.01e-04	180	60	4	d1a8b25115c80e5a5bd0b8244167a98250ab9778
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC91 DPP6 DST ATP10A	1.04e-04	181	60	4	5bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC91 DPP6 DST ATP10A	1.04e-04	181	60	4	8e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-innate_lymphocytic-innate_lymphoid_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DST NEK10 SYNE2 HSP90AA2P	1.06e-04	182	60	4	b86690c109cdc16844a6cd2216c1bf2bf28efd45
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC91 DPP6 DST ATP10A	1.13e-04	185	60	4	9197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC91 DPP6 DST ATP10A	1.13e-04	185	60	4	ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC91 DPP6 DST ATP10A	1.13e-04	185	60	4	b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell	renal_medulla_nuclei-Adult_normal_reference\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	AFMID DPP6 NEK10 OSBPL3	1.25e-04	190	60	4	f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ToppCell	ILEUM-non-inflamed-(8)_Activated_fibroblasts\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	RIN1 STXBP1 PIMREG KIF13A	1.25e-04	190	60	4	39fa110d19c97c7cac99f5fb91b26bc08e2f3b42
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP40 SYNE1 SYNE2 ST6GALNAC2	1.33e-04	193	60	4	f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	KIAA0825 NEK10 SYNE1 DNAH11	1.33e-04	193	60	4	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP40 SYNE1 SYNE2 ST6GALNAC2	1.33e-04	193	60	4	42df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCell	COPD-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	HIPK3 MDN1 SYNE2 LTV1	1.35e-04	194	60	4	8dcde77767b23e75360adb316cdccf56a00e3726
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DST STXBP1 KIAA0825 SHANK3	1.35e-04	194	60	4	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)\|390C / Donor, Lineage, Cell class and subclass (all cells)	DST SUSD2 KIF13A ATP10A	1.35e-04	194	60	4	88db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	DST SUSD2 KIF13A ATP10A	1.35e-04	194	60	4	a71728202493d4858342ea2756ea281cd0d99a3a
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRAF3IP1 NEK10 SYNE1 DNAH11	1.35e-04	194	60	4	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	NEK10 SYNE1 SYNE2 DNAH11	1.38e-04	195	60	4	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	NEK10 SYNE1 SYNE2 DNAH11	1.38e-04	195	60	4	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRAF3IP1 NEK10 SYNE1 DNAH11	1.44e-04	197	60	4	91637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRAF3IP1 NEK10 SYNE1 DNAH11	1.44e-04	197	60	4	22c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRAF3IP1 NEK10 SYNE1 DNAH11	1.44e-04	197	60	4	3bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRAF3IP1 NEK10 SYNE1 DNAH11	1.44e-04	197	60	4	87db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	TGFB2 DPP6 OSBPL3 SYNE2	1.49e-04	199	60	4	d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCell	ASK452-Epithelial\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	TGFB2 DST SUSD2 HSP90AA1	1.49e-04	199	60	4	e8778d4d2bc7e15b4c7989a93e5808a76738df46
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TGFB2 DPP6 OSBPL3 SYNE2	1.49e-04	199	60	4	a270630626df614f8605abddb7dee7c4d74f6149
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	HGF DST SYNE1 CREB3L1	1.49e-04	199	60	4	e1849505b92820a219c5a2c35492bdd55579fb48
ToppCell	Hematolymphoid-Endothelial-NOSTRIN\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SYNE1 SYNE2 ATP10A SHANK3	1.52e-04	200	60	4	032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCell	Control_saline-Mesenchymal_fibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	HGF SYNE1 CREB3L1 LRRC17	1.52e-04	200	60	4	64ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCell	Hematolymphoid-Endothelial-NOSTRIN---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SYNE1 SYNE2 ATP10A SHANK3	1.52e-04	200	60	4	68fce28690246895fd33354b30960ebcc31aa4cc
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	TGFB2 DPP6 OSBPL3 SYNE2	1.52e-04	200	60	4	8683445ad5b70748c4a1f12eb77d47623085147e
ToppCell	Hematolymphoid-Endothelial-NOSTRIN-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SYNE1 SYNE2 ATP10A SHANK3	1.52e-04	200	60	4	376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Mild / Disease, condition lineage and cell class	MDN1 DST SYNE2 UBASH3A	1.52e-04	200	60	4	d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DST STXBP1 KIAA0825 SYNE2	1.52e-04	200	60	4	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	Hematolymphoid-Endothelial-NOSTRIN--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SYNE1 SYNE2 ATP10A SHANK3	1.52e-04	200	60	4	7fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts\|Control_saline / Treatment groups by lineage, cell group, cell type	HGF SYNE1 CREB3L1 LRRC17	1.52e-04	200	60	4	a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCell	Hematolymphoid-Endothelial-NOSTRIN----L2-6\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SYNE1 SYNE2 ATP10A SHANK3	1.52e-04	200	60	4	878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCell	Hematolymphoid-Endothelial\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SYNE1 SYNE2 ATP10A SHANK3	1.52e-04	200	60	4	7136936d05ab344a560cf159684c881063b5430d
Computational	Genes upregulated in subsets of cells of a given type within various tumors	SLK DST PHF3 SYNE2	1.73e-05	50	34	4	GAVISH_3CA_MALIGNANT_METAPROGRAM_4_CHROMATIN
Drug	AC1L9LMC	RIN1 VPS18 DST SYNE1 SYNE2	2.89e-06	83	61	5	CID000448113
Drug	AC1L85F0	SLC4A9 HSP90AA1 HSP90AA2P	5.13e-06	13	61	3	CID000372766
Drug	2qfo	HSP90AA1 HSP90AA2P	7.06e-06	2	61	2	CID000600769
Drug	3-amino-5-chlorobenzoic acid	HSP90AA1 HSP90AA2P	7.06e-06	2	61	2	CID010986726
Drug	3eko	HSP90AA1 HSP90AA2P	7.06e-06	2	61	2	CID011160307
Drug	monocillin III	HSP90AA1 HSP90AA2P	7.06e-06	2	61	2	CID006478910
Drug	pochonin A	HSP90AA1 HSP90AA2P	7.06e-06	2	61	2	CID006478909
Drug	1uyi	HSP90AA1 HSP90AA2P	7.06e-06	2	61	2	CID005289232
Drug	PU-H71	HSP90AA1 HSP90AA2P	7.06e-06	2	61	2	CID009549213
Drug	NSC683666	HSP90AA1 HSP90AA2P	7.06e-06	2	61	2	CID005469153
Drug	H 64	HSP90AA1 HSP90AA2P	7.06e-06	2	61	2	CID006914564
Drug	SureCN4151355	HSP90AA1 HSP90AA2P	7.06e-06	2	61	2	CID015942101
Drug	1uyc	HSP90AA1 HSP90AA2P	7.06e-06	2	61	2	CID000448969
Drug	PU-9	HSP90AA1 HSP90AA2P	7.06e-06	2	61	2	CID000448971
Drug	P u 0	HSP90AA1 HSP90AA2P	7.06e-06	2	61	2	CID000448974
Drug	2qf6	HSP90AA1 HSP90AA2P	7.06e-06	2	61	2	CID013373715
Drug	CHEBI:42139	HSP90AA1 HSP90AA2P	7.06e-06	2	61	2	CID011562562
Drug	Canavanine sulfate monohydrate (L,+) [206996-57-8]; Up 200; 13.6uM; PC3; HT_HG-U133A	HIPK3 RIN1 L3MBTL1 KIF13A CREB3L1 LRRC17	1.54e-05	199	61	6	4197_UP
Drug	compound 9b	SYNE1 HSP90AA1 HSP90AA2P	2.02e-05	20	61	3	CID000207510
Drug	pochonin D	HSP90AA1 HSP90AA2P	2.11e-05	3	61	2	CID006478913
Drug	azaquinone	HSP90AA1 HSP90AA2P	2.11e-05	3	61	2	CID000099132
Drug	d 1 v	HSP90AA1 HSP90AA2P	2.11e-05	3	61	2	CID000683940
Drug	HM-9	HSP90AA1 HSP90AA2P	2.11e-05	3	61	2	CID000433437
Drug	Glyoxylspermidine	HSP90AA1 HSP90AA2P	2.11e-05	3	61	2	CID000133564
Drug	AC1MD0RC	HSP90AA1 HSP90AA2P	2.11e-05	3	61	2	CID002829073
Drug	Wang resin	DST SPTA1	2.11e-05	3	61	2	CID000070043
Drug	hept-2-ene	AFMID SYNE1	2.11e-05	3	61	2	CID000011611
Drug	o668	CREB3L1 HSP90AA1 HSP90AA2P	2.35e-05	21	61	3	CID000004109
Drug	alachlor	AFMID CREB3L1 HSP90AA1 HSP90AA2P	3.96e-05	71	61	4	CID000002078
Drug	pU-2	SYNE2 HSP90AA1 HSP90AA2P	4.04e-05	25	61	3	CID000448973
Drug	uranyl chloride	HSP90AA1 HSP90AA2P	4.22e-05	4	61	2	CID000082259
Drug	methoxyhydroquinone	HSP90AA1 HSP90AA2P	4.22e-05	4	61	2	CID000069988
Drug	11p110	HSP90AA1 HSP90AA2P	4.22e-05	4	61	2	CID002382787
Drug	SC-10	HGF HSP90AA1 HSP90AA2P	5.72e-05	28	61	3	CID000005175
Drug	plakin	DST SYNE1 SPTA1 SYNE2	6.98e-05	82	61	4	CID000018752
Drug	1uy7	HSP90AA1 HSP90AA2P	7.02e-05	5	61	2	CID005289227
Drug	1uyd	HSP90AA1 HSP90AA2P	7.02e-05	5	61	2	CID000448970
Drug	pentafluoropyridine	SYNE1 CREB3L1	7.02e-05	5	61	2	CID000069690
Drug	Org 31806	HSP90AA1 HSP90AA2P	7.02e-05	5	61	2	CID000164147
Drug	CRT0044876	HSP90AA1 HSP90AA2P	7.02e-05	5	61	2	CID000081409
Drug	HCV-796	HSP90AA1 HSP90AA2P	7.02e-05	5	61	2	CID011561383
Drug	MTBSTFA	AFMID CREB3L1	7.02e-05	5	61	2	CID002724275
Drug	chaetochromin	HSP90AA1 HSP90AA2P	7.02e-05	5	61	2	CID000053277
Drug	Dr 27	TGFB2 HGF	7.02e-05	5	61	2	CID006449937
Drug	1,1-diphenyl-2-propyn-1-ol	HSP90AA1 HSP90AA2P	7.02e-05	5	61	2	CID000092976
Drug	RU 58668	TGFB2 HSP90AA1 HSP90AA2P	9.43e-05	33	61	3	CID000119604
Drug	Hantzsch ester	HSP90AA1 HSP90AA2P	1.05e-04	6	61	2	CID000070849
Drug	3-aminocoumarin	HSP90AA1 HSP90AA2P	1.05e-04	6	61	2	CID000074217
Drug	Pu x	HSP90AA1 HSP90AA2P	1.05e-04	6	61	2	CID000448976
Drug	aminopyrimidine	SYNE1 HSP90AA1 HSP90AA2P	1.13e-04	35	61	3	CID000007978
Drug	AG957	HGF HSP90AA1 HSP90AA2P	1.13e-04	35	61	3	CID000002064
Drug	phenazine	DPP6 MCCC2 HSP90AA1 HSP90AA2P	1.24e-04	95	61	4	CID000004757
Drug	alitame	AASDHPPT CREB3L1	1.47e-04	7	61	2	CID000064763
Drug	17-aminogeldanamycin	HSP90AA1 HSP90AA2P	1.47e-04	7	61	2	CID000429444
Drug	Nepl	HSP90AA1 HSP90AA2P	1.47e-04	7	61	2	CID006439214
Drug	NSC330499	HSP90AA1 HSP90AA2P	1.47e-04	7	61	2	CID000433447
Drug	1,2,4,7,8-pentachlorodibenzo-p-dioxin	HSP90AA1 HSP90AA2P	1.47e-04	7	61	2	CID000042836
Drug	Zlll-mca	HSP90AA1 HSP90AA2P	1.47e-04	7	61	2	CID000132936
Drug	dienochlor	HSP90AA1 HSP90AA2P	1.47e-04	7	61	2	CID000016686
Drug	11-deoxy-16,16-dimethyl Prostaglandin E2; Up 200; 10uM; PC3; HT_HG-U133A	TGFB2 TRAF3IP1 FIP1L1 CREB3L1 ST6GALNAC2	1.60e-04	191	61	5	7538_UP
Drug	Etomidate [33125-97-2]; Up 200; 16.4uM; HL60; HT_HG-U133A	OSBPL3 SYNE1 TLN2 ATP10A ST6GALNAC2	1.81e-04	196	61	5	2958_UP
Drug	acetate	TGFB2 DST MAPKAPK3 MCCC2 CREB3L1 HSP90AA1 HSP90AA2P DNAH11	1.89e-04	599	61	8	CID000000175
Drug	Nefopam hydrochloride [23327-57-3]; Down 200; 13.8uM; PC3; HT_HG-U133A	SYNE1 LMTK2 TLN2 ATP10A ST6GALNAC2	1.90e-04	198	61	5	3730_DN
Drug	Bephenium hydroxynaphthoate [3818-50-6]; Up 200; 9uM; MCF7; HT_HG-U133A	HIPK3 HGF TRAF3IP1 SPTA1 TLN2	1.90e-04	198	61	5	5628_UP
Drug	phenyldichloroarsine	HSP90AA1 HSP90AA2P	1.96e-04	8	61	2	CID000012762
Drug	GGMP	HSP90AA1 HSP90AA2P	1.96e-04	8	61	2	CID006443839
Drug	D-box	HSP90AA1 HSP90AA2P	1.96e-04	8	61	2	CID000133881
Drug	triclopyr	AFMID CREB3L1	1.96e-04	8	61	2	CID000041428
Drug	9-phenanthrol	HSP90AA1 HSP90AA2P	1.96e-04	8	61	2	CID000010229
Drug	Dequalinium-14	AFMID SYNE1	2.51e-04	9	61	2	CID000002497
Drug	5,8-quinolinedione	HSP90AA1 HSP90AA2P	2.51e-04	9	61	2	CID000388306
Drug	antheridiol	HSP90AA1 HSP90AA2P	2.51e-04	9	61	2	CID000159927
Drug	JJ3	HSP90AA1 HSP90AA2P	2.51e-04	9	61	2	CID009927355
Drug	DOTP	AFMID SYNE1	2.51e-04	9	61	2	CID000129981
Drug	boceprevir	HSP90AA1 HSP90AA2P	2.51e-04	9	61	2	CID010324367
Drug	nibentan	HSP90AA1 HSP90AA2P	2.51e-04	9	61	2	CID000177905
Drug	noviose	HSP90AA1 HSP90AA2P	2.51e-04	9	61	2	CID005461025
Drug	bensulfuron-methyl	AFMID CREB3L1 ST6GALNAC2	2.90e-04	48	61	3	CID000054960
Drug	n-C6	HSP90AA1 HSP90AA2P	3.13e-04	10	61	2	CID006420120
Drug	PU-6	HSP90AA1 HSP90AA2P	3.13e-04	10	61	2	CID000448968
Drug	formetanate	HSP90AA1 HSP90AA2P	3.13e-04	10	61	2	CID000031099
Drug	Triethylsilan	AFMID SYNE1	3.13e-04	10	61	2	CID000012052
Drug	AC1L44ZM	HSP90AA1 HSP90AA2P	3.13e-04	10	61	2	CID000200744
Drug	AC1O745K	HGF HSP90AA1 HSP90AA2P	3.28e-04	50	61	3	CID006518178
Drug	Pu-3	HSP90AA1 HSP90AA2P	3.82e-04	11	61	2	CID000448965
Drug	AC1L9ICX	HSP90AA1 HSP90AA2P	3.82e-04	11	61	2	CID000445664
Drug	I-hu	HSP90AA1 HSP90AA2P	3.82e-04	11	61	2	CID009547901
Drug	VER-49009	HSP90AA1 HSP90AA2P	3.82e-04	11	61	2	CID005327095
Drug	2ohu	HSP90AA1 HSP90AA2P	4.58e-04	12	61	2	CID011633167
Drug	4-oxo-2-nonenal	HSP90AA1 HSP90AA2P	4.58e-04	12	61	2	CID006445537
Drug	hydroxyatrazine	AFMID CREB3L1	4.58e-04	12	61	2	CID000016553
Drug	PD-V	STAG1 SYNE1	4.58e-04	12	61	2	CID000444615
Drug	isoxazole	SYNE1 HSP90AA1 HSP90AA2P	4.58e-04	56	61	3	CID000009254
Disease	Autosomal dominant Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	2.43e-05	4	60	2	cv:CN293514
Disease	Autosomal Recessive Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	4.05e-05	5	60	2	C1450051
Disease	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)	SYNE1 SYNE2	4.05e-05	5	60	2	C0410190
Disease	Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	6.07e-05	6	60	2	cv:C0410189
Disease	Muscular Dystrophy, Emery-Dreifuss	SYNE1 SYNE2	6.07e-05	6	60	2	C0410189
Disease	X-Linked Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	8.48e-05	7	60	2	C0751337
Disease	cancer	CCDC91 SLK KIAA0825 NEK10 LMTK2 KIF13A	1.61e-04	400	60	6	MONDO_0004992
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	SYNE1 SYNE2	2.65e-04	12	60	2	DOID:11726 (implicated_via_orthology)
Disease	prostate carcinoma	HGF SLK STXBP1 SYNE2 LMTK2 KIF13A SOWAHB DNAH11	4.27e-04	891	60	8	EFO_0001663
Disease	respiratory failure, COVID-19	TYK2 DST	1.59e-03	29	60	2	EFO_0009686, MONDO_0100096
Disease	Drug habituation	CCDC91 SLK SYNE1	1.68e-03	115	60	3	C0013170
Disease	Substance-Related Disorders	CCDC91 SLK SYNE1	1.68e-03	115	60	3	C0236969
Disease	Drug abuse	CCDC91 SLK SYNE1	1.68e-03	115	60	3	C0013146
Disease	Drug Use Disorders	CCDC91 SLK SYNE1	1.68e-03	115	60	3	C0013222
Disease	Drug Dependence	CCDC91 SLK SYNE1	1.68e-03	115	60	3	C1510472
Disease	Substance Dependence	CCDC91 SLK SYNE1	1.68e-03	115	60	3	C0038580
Disease	Substance Use Disorders	CCDC91 SLK SYNE1	1.68e-03	115	60	3	C0038586
Disease	Organic Mental Disorders, Substance-Induced	CCDC91 SLK SYNE1	1.68e-03	115	60	3	C0029231
Disease	Prescription Drug Abuse	CCDC91 SLK SYNE1	1.68e-03	115	60	3	C4316881
Disease	Substance abuse problem	CCDC91 SLK SYNE1	1.72e-03	116	60	3	C0740858

Protein segments in the cluster

Peptide	Gene	Start	Entry
THLHHRWVLFEEKLE	SLC4A9	96	Q96Q91
KEWAFEESKIDEHHF	AASDHPPT	226	Q9NRN7
PDFSHSKEWFHDRDL	CREB3L1	496	Q96BA8
EAHKRHEWQDEFSHI	FBXO4	296	Q9UKT5
DELFGFIHHATREWK	DNAH11	2211	Q96DT5
DLWEDYSRHRSDHKI	ATP10A	126	O60312
EWKASFEELHDVDHF	AFMID	266	Q63HM1
HEEFNEWFSKDIESH	INO80	706	Q9ULG1
EHSWDLDREKNREHD	TRAF3IP1	286	Q8TDR0
KLLEDDFWADVSTLH	MDN1	4556	Q9NU22
KTHRAIADHLFWSEE	LTV1	221	Q96GA3
HTARVLQEDKDHWDE	MAPKAPK3	316	Q16644
SAHHRWNFDDLLEKI	DRG1	271	Q9Y295
SILQDAESHHWDDYK	KIAA0825	606	Q8IV33
WALDDHHALHLTRKV	MCCC2	276	Q9HCC0
EFHSVVHALLEWLAE	DST	6926	Q03001
TEDDEWEKKHRDHTA	LRRC17	416	Q8N6Y2
KWERDEDSLHHGSLF	DCAF8L2	561	P0C7V8
EKHHHFTEERLWKIF	NEK10	621	Q6ZWH5
DVEDHRIKIHFDGWS	L3MBTL1	541	Q9Y468
WDVHVHSDLAKDLDE	FIP1L1	31	Q6UN15
YVWEAAKHDHFDERS	LMTK2	476	Q8IWU2
DLHRHIFWEPDASKL	HGF	421	P14210
SAADPWEKEHHRLSV	PIMREG	151	Q9BSJ6
HSGWRLKTLEEHEAE	HIPK3	441	Q9H422
EDIWFHVDKLSSAHV	CCDC25	36	Q86WR0
WDDISESAKDFIRHL	PNCK	236	Q6P2M8
EEDATEAWRLHQKHV	MON1A	241	Q86VX9
KAHAEERELWKTEHA	CCDC91	331	Q7Z6B0
YLHDDAWTKAETDHL	DMAP1	146	Q9NPF5
LTNDWEDHLAVKHFS	HSP90AA1	316	P07900
KHEDESEAWLHRQNE	DPP6	421	P42658
TNDWEDHLAVKHFSV	HSP90AA2P	316	Q14568
EEVFDEWVSKLRHHR	OSBPL3	131	Q9H4L5
WEVDSLHAKTRTLHD	KIF13A	966	Q9H1H9
WHIRLKLYHSEEDTS	RSBN1L	686	Q6PCB5
HALAWHLSDDFREDP	SUSD2	271	Q9UGT4
HKELEAISHLGIEFW	RIN1	171	Q13671
AAIWELEERHLQEKH	SLK	1006	Q9H2G2
LDAVHEFTDWLHSAK	SYNE1	2846	Q8NF91
EFTDWLHSAKEELHR	SYNE1	2851	Q8NF91
KDHLQLREAWDGLDH	SYNE2	361	Q8WXH0
EHFFLHREWISKDPS	KIR3DS1	151	Q14943
HDLSLEAALWRDLHK	ST6GALNAC2	351	Q9UJ37
SEELRETHSLWEALH	SYCE1L	66	A8MT33
ETHSLWEALHRELDS	SYCE1L	71	A8MT33
LDEDDDLWIALRHKH	STXBP1	281	P61764
HKSSLVPLDAREHEW	SOWAHB	586	A6NEL2
FDVTDAVHEWLHHKD	TGFB2	201	P61812
SWDEVHHNDASDLLK	ARHGAP40	336	Q5TG30
WLESIHLGEHRDRFE	SHANK3	1676	Q9BYB0
HLHREDKHITIEDLW	STIM2	111	Q9P246
RHKEWLFASRASIHE	VPS18	531	Q9P253
WDAADDIHRSLMVDH	SRA1	161	Q9HD15
DSHHLKRERHEKEWE	PHF3	1926	Q92576
TDLDQFLHHWDVTEA	TEX10	721	Q9NXF1
ELHEHAAYLVDSLWE	STAG1	476	Q8WVM7
HEETKAHIEELRHLW	SPTA1	126	P02549
WDTAVHDASEEYKHR	TMEM222	121	Q9H0R3
KLHTDDDLNWLDHSR	TLN2	166	Q9Y4G6
DHIHWRTLEDGKKEA	TXNDC12	36	O95881
GRKTAEEALAWLHDH	UBASH3A	46	P57075
SLWELSTEEEIHHFK	TYK2	166	P29597