Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Pept_his_AS	TINAGL1 CTSB	5.36e-05	11	19	2	IPR025660
Domain	Peptidase_C1	TINAGL1 CTSB	7.60e-05	13	19	2	PF00112
Domain	Peptidase_C1A	TINAGL1 CTSB	7.60e-05	13	19	2	IPR013128
Domain	Pept_C1	TINAGL1 CTSB	7.60e-05	13	19	2	SM00645
Domain	Peptidase_C1A_C	TINAGL1 CTSB	7.60e-05	13	19	2	IPR000668
Domain	THIOL_PROTEASE_HIS	TINAGL1 CTSB	3.39e-04	27	19	2	PS00639
Domain	Pept_cys_AS	TINAGL1 CTSB	3.65e-04	28	19	2	IPR000169
Domain	Collagen	WDR33 C1QL4	3.33e-03	85	19	2	PF01391
Domain	Collagen	WDR33 C1QL4	3.33e-03	85	19	2	IPR008160
Domain	RRM_1	SETD1A HNRNPM	1.86e-02	208	19	2	PF00076
Domain	RRM	SETD1A HNRNPM	2.02e-02	217	19	2	SM00360
Domain	RRM_dom	SETD1A HNRNPM	2.20e-02	227	19	2	IPR000504
Domain	RRM	SETD1A HNRNPM	2.25e-02	230	19	2	PS50102
Pathway	REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION	CTSB DYNC1H1 SPTBN2	2.30e-04	116	15	3	MM14855
Pathway	REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION	CTSB DYNC1H1 SPTBN2	2.93e-04	126	15	3	M705
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	POLR1D WDR33 CDSN DYNC1H1 SPTBN2 SON HNRNPM	3.13e-06	1082	22	7	38697112
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	CDSN DYNC1H1 SPTBN2 SON HNRNPM	1.03e-05	477	22	5	31300519
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	TINAGL1 CTSB CDSN GALNT2	1.67e-05	248	22	4	24006456
Pubmed	The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2.	ARMCX6 ARMCX4	2.09e-05	11	22	2	22569362
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	SETD1A DYNC1H1 SPTBN2	3.84e-05	104	22	3	9205841
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	WDR33 SON HNRNPM	7.46e-05	130	22	3	35545047
Pubmed	Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events.	ARMCX6 ARMCX4	1.05e-04	24	22	2	16221301
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	SETD1A DYNC1H1 SON HNRNPM	1.41e-04	430	22	4	35044719
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	POLR1D SETD1A CDSN DYNC1H1 SON HNRNPM	1.50e-04	1353	22	6	29467282
Pubmed	SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.	TINAGL1 DYNC1H1 HNRNPM	1.74e-04	173	22	3	23979707
Pubmed	Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.	CTSB DYNC1H1	2.12e-04	34	22	2	25915474
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ADGRB2 DYNC1H1 SPTBN2 ARMCX4 HNRNPM	2.86e-04	963	22	5	28671696
Pubmed	Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.	WDR33 DYNC1H1	3.40e-04	43	22	2	34672947
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	WDR33 SETD1A DYNC1H1 SPTBN2	3.58e-04	549	22	4	38280479
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	ADGRB2 DYNC1H1 SPTBN2	5.17e-04	251	22	3	27507650
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	DYNC1H1 SON HNRNPM	5.41e-04	255	22	3	15324660
Pubmed	BioID-based proteomic analysis of the Bid interactome identifies novel proteins involved in cell-cycle-dependent apoptotic priming.	DYNC1H1 SON	5.56e-04	55	22	2	33067418
Pubmed	ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.	DYNC1H1 HNRNPM GALNT2	6.25e-04	268	22	3	33024031
Cytoband	11q13	MYEOV SPTBN2	1.46e-03	118	22	2	11q13
Cytoband	Ensembl 112 genes in cytogenetic band chr1p35	ADGRB2 TINAGL1	1.96e-03	137	22	2	chr1p35
Cytoband	Ensembl 112 genes in cytogenetic band chrXq22	ARMCX6 ARMCX4	3.07e-03	172	22	2	chrXq22
Cytoband	Ensembl 112 genes in cytogenetic band chr11q13	MYEOV SPTBN2	1.98e-02	454	22	2	chr11q13
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	ARMCX6 ARMCX4	7.35e-04	43	17	2	409
GeneFamily	RNA binding motif containing	SETD1A HNRNPM	1.67e-02	213	17	2	725
Disease	Hepatic fibrosis	KLHL6 TINAGL1	5.04e-04	49	20	2	HP_0001395
Disease	triglyceride measurement, intermediate density lipoprotein measurement	CTSB GALNT2	2.55e-03	111	20	2	EFO_0004530, EFO_0008595
Disease	choline measurement	CTSB GALNT2	3.47e-03	130	20	2	EFO_0010116
Disease	phospholipid measurement	CTSB GALNT2	4.02e-03	140	20	2	EFO_0004639
Disease	triglyceride measurement, low density lipoprotein cholesterol measurement	CTSB GALNT2	5.59e-03	166	20	2	EFO_0004530, EFO_0004611
Disease	heel bone mineral density, urate measurement	MYEOV SON	6.68e-03	182	20	2	EFO_0004531, EFO_0009270
Disease	X-12063 measurement	ADGRB2 TINAGL1	6.97e-03	186	20	2	EFO_0021283
Disease	coronary artery disease	WDR33 GP2 HNRNPM GALNT2	7.69e-03	1194	20	4	EFO_0001645

Protein segments in the cluster

Peptide	Gene	Start	Entry
MENTGWMGKGHRMTP	ADGRB2	1	O60241
TGEMMGGHAIRILGW	CTSB	271	P07858
LMRGGDGTSMWADLM	C1QL4	161	Q86Z23
APWMGRVGGHGMMAL	CDSN	6	Q15517
MVPGAGMGSWDGAMI	ARMCX4	1981	Q5H9R4
MGRAREVGWMAAGLM	ARMCX6	1	Q7L4S7
VMVWIHGGGLMVGAA	CES1P1	136	Q9UKY3
MLMAGQRGAWTMGDV	KLHL6	1	Q8WZ60
MMMDVWGGENLEISF	GALNT2	326	Q10471
MERMGAGLGHGMDRV	HNRNPM	416	P52272
MERIGSGVERMGAGM	HNRNPM	476	P52272
MPHLMERMVGSGLLW	GP2	1	P55259
GRHGLSMEIMWARMD	MYEOV	186	Q96EZ4
MMVGPSGSGKSMAWR	DYNC1H1	2221	Q14204
LMVGGAWVGGFMHAM	OR4C6	141	Q8NH72
RGKTRAETMGPMGWM	POLR1D	21	P0DPB5
FVLGVWGRVGMEDMG	TINAGL1	451	Q9GZM7
MAAGQSMRQGGMGVW	SLC6A16	161	Q9GZN6
MDRLGAQWGGMPMSF	SETD1A	666	O15047
EAWMGEQELHMMGQE	SPTBN2	1601	O15020
DTEVLMWMGMTFGLE	TFDP3	291	Q5H9I0
EVGGMEMAHEGMIWS	WDR33	366	Q9C0J8
GGMGAVLMRKMGWRE	SON	2306	P18583