Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	natriuretic peptide receptor activity	NPR1 NPR2	6.01e-05	3	90	2	GO:0016941
GeneOntologyMolecularFunction	rRNA (cytosine-C5-)-methyltransferase activity	NSUN5 NSUN5P2	1.20e-04	4	90	2	GO:0009383
GeneOntologyMolecularFunction	rRNA (cytosine) methyltransferase activity	NSUN5 NSUN5P2	2.98e-04	6	90	2	GO:0016434
GeneOntologyMolecularFunction	prolactin receptor binding	CSH2 CSHL1	4.16e-04	7	90	2	GO:0005148
GeneOntologyMolecularFunction	C-methyltransferase activity	NSUN5 NSUN5P2	5.53e-04	8	90	2	GO:0008169
GeneOntologyMolecularFunction	guanylate cyclase activity	NPR1 NPR2	8.83e-04	10	90	2	GO:0004383
GeneOntologyMolecularFunction	growth hormone receptor binding	CSH2 CSHL1	8.83e-04	10	90	2	GO:0005131
GeneOntologyMolecularFunction	14-3-3 protein binding	DAB2IP KIF13B KCNH1	8.95e-04	42	90	3	GO:0071889
Domain	GPCR_2_brain_angio_inhib	ADGRB1 ADGRB2	7.02e-05	3	91	2	IPR008077
Domain	ANF_RECEPTORS	NPR1 NPR2	7.02e-05	3	91	2	PS00458
Domain	RFX1_trans_act	RFX2 RFX3	7.02e-05	3	91	2	IPR007668
Domain	ANPR/GUC	NPR1 NPR2	7.02e-05	3	91	2	IPR001170
Domain	RFX1_trans_act	RFX2 RFX3	7.02e-05	3	91	2	PF04589
Domain	HormR	GIPR ADGRB1 ADGRB2	2.38e-04	25	91	3	SM00008
Domain	HRM	GIPR ADGRB1 ADGRB2	3.36e-04	28	91	3	PF02793
Domain	SOMATOTROPIN_2	CSH2 CSHL1	3.48e-04	6	91	2	PS00338
Domain	Hormone_1	CSH2 CSHL1	3.48e-04	6	91	2	PF00103
Domain	SOMATOTROPIN_1	CSH2 CSHL1	3.48e-04	6	91	2	PS00266
Domain	Somatotropin	CSH2 CSHL1	4.85e-04	7	91	2	IPR001400
Domain	MeTrfase_RsmB/NOP2	NSUN5 NSUN5P2	6.45e-04	8	91	2	IPR001678
Domain	Methyltr_RsmB-F	NSUN5 NSUN5P2	6.45e-04	8	91	2	PF01189
Domain	RFX_DNA_binding	RFX2 RFX3	8.27e-04	9	91	2	PF02257
Domain	DNA-bd_RFX	RFX2 RFX3	8.27e-04	9	91	2	IPR003150
Domain	RFX_DBD	RFX2 RFX3	8.27e-04	9	91	2	PS51526
Domain	G_PROTEIN_RECEP_F2_1	GIPR ADGRB1 ADGRB2	9.70e-04	40	91	3	PS00649
Domain	GPCR_2_extracellular_dom	GIPR ADGRB1 ADGRB2	9.70e-04	40	91	3	IPR001879
Domain	G_PROTEIN_RECEP_F2_3	GIPR ADGRB1 ADGRB2	9.70e-04	40	91	3	PS50227
Domain	GAIN_dom_N	ADGRB1 ADGRB2	1.25e-03	11	91	2	IPR032471
Domain	GAIN	ADGRB1 ADGRB2	1.25e-03	11	91	2	PF16489
Domain	G_PROTEIN_RECEP_F2_2	GIPR ADGRB1 ADGRB2	1.86e-03	50	91	3	PS00650
Domain	7tm_2	GIPR ADGRB1 ADGRB2	1.86e-03	50	91	3	PF00002
Domain	MFS	SPNS1 MFSD6L SLC22A20P SLC16A8	1.92e-03	108	91	4	PS50850
Domain	ARM-like	IPO5 RELCH RTTN ARMC9 MEI1 TRRAP	2.06e-03	270	91	6	IPR011989
Domain	A/G_cyclase_CS	NPR1 NPR2	3.04e-03	17	91	2	IPR018297
Domain	GPCR_2_secretin-like	GIPR ADGRB1 ADGRB2	3.13e-03	60	91	3	IPR000832
Domain	GPCR_2-like	GIPR ADGRB1 ADGRB2	3.13e-03	60	91	3	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	GIPR ADGRB1 ADGRB2	3.28e-03	61	91	3	PS50261
Domain	Nucleotide_cyclase	NPR1 NPR2	3.41e-03	18	91	2	IPR029787
Domain	-	NPR1 NPR2	3.41e-03	18	91	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	NPR1 NPR2	3.80e-03	19	91	2	PS00452
Domain	Guanylate_cyc	NPR1 NPR2	3.80e-03	19	91	2	PF00211
Domain	GUANYLATE_CYCLASE_2	NPR1 NPR2	3.80e-03	19	91	2	PS50125
Domain	A/G_cyclase	NPR1 NPR2	3.80e-03	19	91	2	IPR001054
Domain	CYCc	NPR1 NPR2	3.80e-03	19	91	2	SM00044
Domain	MFS_dom	SPNS1 MFSD6L SLC22A20P SLC16A8	4.18e-03	134	91	4	IPR020846
Domain	-	IPO5 RELCH RTTN ARMC9 TRRAP	4.61e-03	222	91	5	1.25.10.10
Domain	ARM-type_fold	IPO5 RELCH RTTN ARMC9 MEI1 TRRAP	6.26e-03	339	91	6	IPR016024
Pubmed	Both estrogen receptor α and β stimulate pituitary GH gene expression.	CSH2 CSHL1 ESR2	6.02e-07	7	91	3	24284820
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DAB2IP TBC1D16 SLC2A4RG SHANK2 NUP85 RTTN MARK4 ADGRB2 SFI1 SPPL2B TRRAP CEP170B SMG6	6.06e-06	1105	91	13	35748872
Pubmed	Cognitive deficits in mice lacking Nsun5, a cytosine-5 RNA methyltransferase, with impairment of oligodendrocyte precursor cells.	NSUN5 NSUN5P2	6.77e-06	2	91	2	30485550
Pubmed	The pseudokinase domains of guanylyl cyclase-A and -B allosterically increase the affinity of their catalytic domains for substrate.	NPR1 NPR2	6.77e-06	2	91	2	30696704
Pubmed	Mice with NOP2/sun RNA methyltransferase 5 deficiency die before reaching puberty due to fatal kidney damage.	NSUN5 NSUN5P2	6.77e-06	2	91	2	38712768
Pubmed	Adenine nucleotides decrease the apparent Km of endogenous natriuretic peptide receptors for GTP.	NPR1 NPR2	6.77e-06	2	91	2	17848634
Pubmed	Chimeric natriuretic peptide ACNP stimulates both natriuretic peptide receptors, the NPRA and NPRB.	NPR1 NPR2	6.77e-06	2	91	2	23186809
Pubmed	RNA-methyltransferase Nsun5 controls the maternal-to-zygotic transition by regulating maternal mRNA stability.	NSUN5 NSUN5P2	6.77e-06	2	91	2	36495115
Pubmed	Mass spectrometric identification of phosphorylation sites in guanylyl cyclase A and B.	NPR1 NPR2	6.77e-06	2	91	2	20977274
Pubmed	ATP potentiates competitive inhibition of guanylyl cyclase A and B by the staurosporine analog, Gö6976: reciprocal regulation of ATP and GTP binding.	NPR1 NPR2	6.77e-06	2	91	2	21828054
Pubmed	Infiltrating T cells promote renal cell carcinoma (RCC) progression via altering the estrogen receptor β-DAB2IP signals.	DAB2IP ESR2	6.77e-06	2	91	2	26587829
Pubmed	Porcine natriuretic peptide type B (pNPPB) maintains mouse oocyte meiotic arrest via natriuretic peptide receptor 2 (NPR2) in cumulus cells.	NPR1 NPR2	6.77e-06	2	91	2	24615855
Pubmed	Vasonatrin peptide stimulates both of the natriuretic peptide receptors, NPRA and NPRB.	NPR1 NPR2	6.77e-06	2	91	2	24699414
Pubmed	Guanylyl cyclase (GC)-A and GC-B activities in ventricles and cardiomyocytes from failed and non-failed human hearts: GC-A is inactive in the failed cardiomyocyte.	NPR1 NPR2	6.77e-06	2	91	2	22133375
Pubmed	Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth.	NSUN5 NSUN5P2	6.77e-06	2	91	2	31722427
Pubmed	Agenesis and Hypomyelination of Corpus Callosum in Mice Lacking Nsun5, an RNA Methyltransferase.	NSUN5 NSUN5P2	6.77e-06	2	91	2	31174389
Pubmed	Guanylyl cyclases A and B are asymmetric dimers that are allosterically activated by ATP binding to the catalytic domain.	NPR1 NPR2	6.77e-06	2	91	2	22949736
Pubmed	NSUN5 is essential for proper cell proliferation and differentiation of mouse preimplantation embryos.	NSUN5 NSUN5P2	6.77e-06	2	91	2	38670153
Pubmed	Enhanced expression of natriuretic peptide receptor A and B in neutrophils of culprit lesions in patients with acute myocardial infarction.	NPR1 NPR2	6.77e-06	2	91	2	28765884
Pubmed	ATP-independent activation of natriuretic peptide receptors.	NPR1 NPR2	6.77e-06	2	91	2	15911610
Pubmed	The indolocarbazole, Gö6976, inhibits guanylyl cyclase-A and -B.	NPR1 NPR2	6.77e-06	2	91	2	21366551
Pubmed	Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development.	CSH2 CSHL1 TRRAP	1.15e-05	17	91	3	12464179
Pubmed	Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.	RFX2 RFX3	2.03e-05	3	91	2	15024578
Pubmed	The human growth hormone gene locus: structure, evolution, and allelic variations.	CSH2 CSHL1	2.03e-05	3	91	2	3030680
Pubmed	Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.	RFX2 RFX3	2.03e-05	3	91	2	10330134
Pubmed	A sensitive method for determining the phosphorylation status of natriuretic peptide receptors: cGK-Ialpha does not regulate NPR-A.	NPR1 NPR2	2.03e-05	3	91	2	16430226
Pubmed	Ciliogenic RFX transcription factors regulate FGF1 gene promoter.	RFX2 RFX3	2.03e-05	3	91	2	22415835
Pubmed	Skeletal muscle derived Musclin protects the heart during pathological overload.	NPR1 NPR2	2.03e-05	3	91	2	35013221
Pubmed	Regulation of natriuretic peptides postprandially in vivo and of their receptors in adipocytes by fatty acids in vitro.	NPR1 NPR2	2.03e-05	3	91	2	29409758
Pubmed	Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1).	ADGRB1 ADGRB2	2.03e-05	3	91	2	9533023
Pubmed	Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.	RFX2 RFX3	2.03e-05	3	91	2	12403718
Pubmed	Chromosomal distribution of three members of the human natriuretic peptide receptor/guanylyl cyclase gene family.	NPR1 NPR2	2.03e-05	3	91	2	1979052
Pubmed	Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma.	ADGRB1 ADGRB2	2.03e-05	3	91	2	15225653
Pubmed	RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.	RFX2 RFX3	2.03e-05	3	91	2	8289803
Pubmed	Cardiac fibrosis in end-stage human heart failure and the cardiac natriuretic peptide guanylyl cyclase system: regulation and therapeutic implications.	NPR1 NPR2	2.03e-05	3	91	2	25117468
Pubmed	Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.	RFX2 RFX3	2.03e-05	3	91	2	32725242
Pubmed	Retinal degeneration protein 3 controls membrane guanylate cyclase activities in brain tissue.	NPR1 NPR2	2.03e-05	3	91	2	36618828
Pubmed	Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize.	NPR1 NPR2	2.03e-05	3	91	2	15459247
Pubmed	NSUN5 Facilitates Viral RNA Recognition by RIG-I Receptor.	NSUN5 NSUN5P2	2.03e-05	3	91	2	33177158
Pubmed	Rapid regulation of K(ATP) channel activity by 17{beta}-estradiol in pancreatic {beta}-cells involves the estrogen receptor {beta} and the atrial natriuretic peptide receptor.	NPR1 ESR2	2.03e-05	3	91	2	19855088
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	NPR1 KCNH1 PURB TIMM50 PCCB NOTCH3	2.18e-05	214	91	6	22199357
Pubmed	Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.	RFX2 RFX3	4.05e-05	4	91	2	11682486
Pubmed	Differential expression of Rfx1-4 during mouse spermatogenesis.	RFX2 RFX3	4.05e-05	4	91	2	19596083
Pubmed	Characterization of two novel genes, WBSCR20 and WBSCR22, deleted in Williams-Beuren syndrome.	NSUN5 NSUN5P2	4.05e-05	4	91	2	11978965
Pubmed	Developmental control and alternative splicing of the placentally expressed transcripts from the human growth hormone gene cluster.	CSH2 CSHL1	4.05e-05	4	91	2	1378436
Pubmed	Estrogen receptors in granulosa cells govern meiotic resumption of pre-ovulatory oocytes in mammals.	NPR2 ESR2	4.05e-05	4	91	2	28277543
Pubmed	A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation.	NPR1 NPR2	4.05e-05	4	91	2	19458086
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	DAB2IP RELCH SHANK2 PURB ADGRB1 TIMM50 ADGRB2 PCCB ALDH6A1 CEP170B NDUFV2 MICU1	4.19e-05	1139	91	12	36417873
Pubmed	Central growth hormone action regulates metabolism during pregnancy.	CSH2 CSHL1	6.74e-05	5	91	2	31479305
Pubmed	Molecular evolution of growth hormone and receptor in the guinea-pig, a mammal unresponsive to growth hormone.	CSH2 CSHL1	6.74e-05	5	91	2	10767558
Pubmed	Heterogeneous growth hormone (GH) gene mutations in familial GH deficiency.	CSH2 CSHL1	6.74e-05	5	91	2	8496314
Pubmed	Exploring endocrine GH pattern in mice using rank plot analysis and random blood samples.	CSH2 CSHL1	6.74e-05	5	91	2	21045135
Pubmed	Analysis of gender difference of cardiac risk biomarkers using hGH-transgenic mice.	CSH2 CSHL1	6.74e-05	5	91	2	16508206
Pubmed	Rescue of pituitary function in a mouse model of isolated growth hormone deficiency type II by RNA interference.	CSH2 CSHL1	6.74e-05	5	91	2	18006625
Pubmed	Growth hormone overexpression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and dyslipidemia.	CSH2 CSHL1	6.74e-05	5	91	2	15616010
Pubmed	Nitric oxide stimulates embryonic somatotroph differentiation and growth hormone mRNA and protein expression through a cyclic guanosine monophosphate-independent mechanism.	CSH2 CSHL1	6.74e-05	5	91	2	19019400
Pubmed	The Effects of 20-kDa Human Placental GH in Male and Female GH-deficient Mice: An Improved Human GH?	CSH2 CSHL1	6.74e-05	5	91	2	32556100
Pubmed	High frequency of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice created from two different strains of mice.	CSH2 CSHL1	6.74e-05	5	91	2	1525063
Pubmed	Obesity and elevated plasma leptin concentration in oMT1A-o growth hormone transgenic mice.	CSH2 CSHL1	6.74e-05	5	91	2	11346667
Pubmed	Cardiac contractile function is enhanced in isolated ventricular myocytes from growth hormone transgenic mice.	CSH2 CSHL1	6.74e-05	5	91	2	12010633
Pubmed	Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis.	CSH2 CSHL1	6.74e-05	5	91	2	17626886
Pubmed	Growth hormone prevents the development of autoimmune diabetes.	CSH2 CSHL1	6.74e-05	5	91	2	24218587
Pubmed	Regulation of rapid signal transducer and activator of transcription-5 phosphorylation in the resting cells of the growth plate and in the liver by growth hormone and feeding.	CSH2 CSHL1	6.74e-05	5	91	2	19359380
Pubmed	Body composition of inactivated growth hormone (oMt1a-oGH) transgenic mice: generation of an obese phenotype.	CSH2 CSHL1	6.74e-05	5	91	2	9546108
Pubmed	Transgene transmission to progeny by oMt1a-oGH transgenic mice.	CSH2 CSHL1	6.74e-05	5	91	2	16201410
Pubmed	Growth hormone stimulates the selective trafficking of thymic CD4+CD8- emigrants to peripheral lymphoid organs.	CSH2 CSHL1	6.74e-05	5	91	2	15316240
Pubmed	Genes that prolong life: relationships of growth hormone and growth to aging and life span.	CSH2 CSHL1	6.74e-05	5	91	2	11487592
Pubmed	Overexpressed growth hormone (GH) synergistically promotes carcinogen-initiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic mice.	CSH2 CSHL1	6.74e-05	5	91	2	11318985
Pubmed	Involvement of insulin-like growth factor-1 in the effect of caloric restriction: regulation of plasma adiponectin and leptin.	CSH2 CSHL1	6.74e-05	5	91	2	17301034
Pubmed	Growth hormone action in the developing neural retina: a proteomic analysis.	CSH2 CSHL1	6.74e-05	5	91	2	18203262
Pubmed	Identification of the glomerular podocyte as a target for growth hormone action.	CSH2 CSHL1	6.74e-05	5	91	2	17272398
Pubmed	Glucose homeostasis and insulin sensitivity in growth hormone-transgenic mice: a cross-sectional analysis.	CSH2 CSHL1	6.74e-05	5	91	2	20707609
Pubmed	Assignment of the porcine growth hormone gene to chromosome 12.	CSH2 CSHL1	6.74e-05	5	91	2	2249485
Pubmed	Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARgamma pathway.	CSH2 CSHL1	6.74e-05	5	91	2	17242167
Pubmed	A single injection of double-stranded adeno-associated viral vector expressing GH normalizes growth in GH-deficient mice.	CSH2 CSHL1	6.74e-05	5	91	2	18180319
Pubmed	Induction of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice.	CSH2 CSHL1	6.74e-05	5	91	2	1874564
Pubmed	Cloning and characterisation of the GH gene from the common dolphin (Delphinus delphis).	CSH2 CSHL1	6.74e-05	5	91	2	12225773
Pubmed	Growth Hormone Deficiency and Excess Alter the Gut Microbiome in Adult Male Mice.	CSH2 CSHL1	6.74e-05	5	91	2	32100023
Pubmed	The related genes encoding growth hormone and prolactin have been dispersed to chromosomes 10 and 17 in the rat.	CSH2 CSHL1	6.74e-05	5	91	2	3780533
Pubmed	High, persistent hepatocellular proliferation and apoptosis precede hepatocarcinogenesis in growth hormone transgenic mice.	CSH2 CSHL1	6.74e-05	5	91	2	10395045
Pubmed	Effect of genetic background on growth of mice hemizygous for wild-type or dwarf mutated bovine growth hormone transgenes.	CSH2 CSHL1	6.74e-05	5	91	2	24190208
Pubmed	Brief report: short stature caused by a mutant growth hormone.	CSH2 CSHL1	6.74e-05	5	91	2	8552145
Pubmed	Promotion of Joint Degeneration and Chondrocyte Metabolic Dysfunction by Excessive Growth Hormone in Mice.	CSH2 CSHL1	6.74e-05	5	91	2	36762426
Pubmed	High molecular weight isoforms of growth hormone in cells of the immune system.	CSH2 CSHL1	6.74e-05	5	91	2	21741628
Pubmed	Structure of the growth hormone-encoding gene and its promoter in mice.	CSH2 CSHL1	6.74e-05	5	91	2	8647448
Pubmed	Thiol-Disulfide Exchange in Human Growth Hormone.	CSH2 CSHL1	6.74e-05	5	91	2	26887678
Pubmed	Transgenic mice expressing bovine GH develop arthritic disorder and self-antibodies.	CSH2 CSHL1	6.74e-05	5	91	2	10810296
Pubmed	The role of growth hormone in fetal mouse reproductive tract differentiation.	CSH2 CSHL1	6.74e-05	5	91	2	8756530
Pubmed	GH Knockout Mice Have Increased Subcutaneous Adipose Tissue With Decreased Fibrosis and Enhanced Insulin Sensitivity.	CSH2 CSHL1	6.74e-05	5	91	2	31099824
Pubmed	Somatotropin transgenic mice have reduced jejunal active glucose transport rates.	CSH2 CSHL1	6.74e-05	5	91	2	7965203
Pubmed	Hot spots for growth hormone gene deletions in homologous regions outside of Alu repeats.	CSH2 CSHL1	6.74e-05	5	91	2	1980158
Pubmed	Vitamin D3 cannot revert desensitization of growth hormone (GH)-induced STAT5-signaling in GH-overexpressing mice non-calcemic tissues.	CSH2 CSHL1	6.74e-05	5	91	2	17881271
Pubmed	Neural growth hormone implicated in body weight sex differences.	CSH2 CSHL1	6.74e-05	5	91	2	23861378
Pubmed	Growth hormone increases low-density lipoprotein receptor and HMG-CoA reductase mRNA expression in mesangial cells.	CSH2 CSHL1	6.74e-05	5	91	2	12759574
Pubmed	Growth hormone production and action in N1E-115 neuroblastoma cells.	CSH2 CSHL1	6.74e-05	5	91	2	19301152
Pubmed	ENaC is regulated by natriuretic peptide receptor-dependent cGMP signaling.	NPR1 NPR2	6.74e-05	5	91	2	23324181
Pubmed	Temporal expression analysis of angiogenesis-related genes in brain development.	NPR1 ADGRB1	6.74e-05	5	91	2	23020941
Pubmed	Adipocyte insensitivity to insulin in growth hormone-transgenic mice.	CSH2 CSHL1	6.74e-05	5	91	2	11350075
Pubmed	Transgenic mice overexpressing growth hormone (GH) have reduced or increased cardiac apoptosis through activation of multiple GH-dependent or -independent cell death pathways.	CSH2 CSHL1	6.74e-05	5	91	2	18617616
Pubmed	Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice.	CSH2 CSHL1	6.74e-05	5	91	2	17347312
Interaction	HSDL2 interactions	GATD3 PMPCB ESR2 PEX5 HINT2 TRRAP ALDH6A1	4.41e-06	151	88	7	int:HSDL2
Interaction	NPPB interactions	NPR1 NPR2 PMPCB TRRAP	6.41e-06	28	88	4	int:NPPB
Interaction	VWA8 interactions	GATD3 PMPCB PARP16 ESR2 TIMM50 PEX5 HINT2 TRRAP NDUFV2	1.85e-05	342	88	9	int:VWA8
Interaction	NDUFB1 interactions	MED24 C3AR1 ALAD SPPL2B NDUFV2	1.92e-05	75	88	5	int:NDUFB1
Cytoband	7q11.23	NSUN5 GTF2I NSUN5P2	9.71e-04	97	91	3	7q11.23
Cytoband	17q24.2	CSH2 CSHL1	1.63e-03	30	91	2	17q24.2
GeneFamily	Adhesion G protein-coupled receptors, subfamily B	ADGRB1 ADGRB2	3.24e-05	3	60	2	912
GeneFamily	Growth hormone family	CSH2 CSHL1	1.61e-04	6	60	2	1175
GeneFamily	Guanylate cyclase receptors	NPR1 NPR2	2.25e-04	7	60	2	343
GeneFamily	Regulatory factor X family	RFX2 RFX3	2.99e-04	8	60	2	1153
Coexpression	GSE29618_PRE_VS_DAY7_POST_LAIV_FLU_VACCINE_PDC_UP	GIPR SHANK2 PARP16 ARMC9 PTGER3 KIF25 SMG6	4.82e-06	196	89	7	M4999
Coexpression	GSE40274_CTRL_VS_FOXP3_AND_GATA1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN	GLS2 GCLM FNDC11 URB2 RFX2 CEP170B	1.25e-05	150	89	6	M9108
ToppCell	11.5-Distal-RBC\|Distal / Age, Tissue, Lineage and Cell class	FAM234B GCLM DHRS13 KEL ALAD GALNT5	1.07e-06	163	91	6	e9d814952d824539ff1dea119e4fca14a8c335a8
ToppCell	11.5-Distal-RBC-RBC\|Distal / Age, Tissue, Lineage and Cell class	FAM234B GCLM DHRS13 KEL ALAD GALNT5	1.07e-06	163	91	6	31b60e065bac4ad380247964e7574f210106ebae
Drug	Disulfiram [97-77-8]; Down 200; 13.4uM; PC3; HT_HG-U133A	PARP16 MARK4 ALAD ARMC9 SFI1 SPPL2B MAP3K6 NOTCH3	1.30e-06	198	91	8	5729_DN
Disease	Williams-Beuren syndrome (implicated_via_orthology)	NSUN5 GTF2I NSUN5P2	1.14e-05	15	88	3	DOID:1928 (implicated_via_orthology)
Disease	osteoporosis (biomarker_via_orthology)	CSH2 CSHL1 ESR2	3.79e-05	22	88	3	DOID:11476 (biomarker_via_orthology)
Disease	isolated growth hormone deficiency type II (implicated_via_orthology)	CSH2 CSHL1	8.74e-05	5	88	2	DOID:0060872 (implicated_via_orthology)
Disease	isolated growth hormone deficiency (implicated_via_orthology)	CSH2 CSHL1	1.83e-04	7	88	2	DOID:0060870 (implicated_via_orthology)
Disease	congenital hypothyroidism (biomarker_via_orthology)	CSH2 CSHL1	7.82e-04	14	88	2	DOID:0050328 (biomarker_via_orthology)
Disease	systemic lupus erythematosus	GTF2I GLS2 COG6 PSMB9 ARMC9 ITGAX GDI2 OLFML3	2.67e-03	799	88	8	MONDO_0007915
Disease	cerebral amyloid deposition measurement	GATD3 DDX25 NDUFV2	2.91e-03	95	88	3	EFO_0007707

Protein segments in the cluster

Peptide	Gene	Start	Entry
TSLFRASSRFLIEMD	URB2	976	Q14146
AVLAMTDRRSVLFQA	ADGRB2	1171	O60241
AAALGLAMFSLLVRR	SMG6	971	Q86US8
MAARAVFLALSAQLL	BAGE	1	Q13072
QFTLADMATRLVAAR	ACAD8	316	Q9UKU7
AVTIAVSSRALFRMD	NT5C1A	51	Q9BXI3
MSAVLAVTDRRSALF	ADGRB1	1151	O14514
MGTDSRAAKALLARA	GCLM	1	P48507
REFDSLGSALAMASL	FBXO10	116	Q9UK96
SDMDLRRTLFANIVL	ACTR1B	286	P42025
MAAGSRTSLLLAFAL	CSHL1	1	Q14406
LFTSFMLRAAAILSR	GIPR	176	P48546
ARMALALLDAVSSFR	NPR2	931	P20594
ARMALALLDAVRSFR	NPR1	946	P16066
LLQDLAATRAARMDF	CEP170B	891	Q9Y4F5
MFASVFLLTAISLDR	C3AR1	106	Q16581
AAFVLAMLSRVNALE	DDX25	151	Q9UHL0
MTRTRAALLLFTALA	ITGAX	1	P20702
LRDFTLAMAARKASR	OLFML3	186	Q9NRN5
AFDLDAKRLASMATL	NSUN5	256	Q96P11
AKRLASMATLLARAG	NSUN5	261	Q96P11
SAGMILASFATRLLE	SLC16A8	96	O95907
QALLSFCRMSADSRL	RELCH	491	Q9P260
KRIASLDAANARLMS	DAB2IP	1136	Q5VWQ8
MAAAAARVVLSSAAR	PMPCB	1	O75439
MAALLAAAAVRARIL	ALDH6A1	1	Q02252
EPSMRAFLLSLAALR	PLD3	371	Q8IV08
ALASSLMGLFEKRRF	GDI2	126	P50395
MAAAVVLAAGLRAAR	HINT2	1	Q9BX68
MAASLSERLFSLELL	MAP10	1	Q9P2G4
IFDMLLATTSRFREL	ESR2	376	Q92731
LKAAVLEAMTAFRRA	ALAD	296	P13716
MGLSSTRAAELLARD	ATP12A	76	P54707
MARLINAFASLAEGR	ARMC9	391	Q7Z3E5
MAAVRALVASRLAAA	GATD3B	1	A0A0B4J2D5
LDFASLARGFALLRM	DDX55	446	Q8NHQ9
MAAGSRTSLLLAFAL	CSH2	1	P0DML3
MFVLDSLLSRAVRAA	MAP3K6	1101	O95382
DLATPRMERALSALF	MFSD6L	481	Q8IWD5
MFRLNSLSALAELAV	MICU1	1	Q9BPX6
SRTREAALDARFLVM	EID3	81	Q8N140
KRFADAASLLLSLMT	NUP85	551	Q9BW27
FIASAMAVERALAIR	PTGER3	146	P43115
GAADARDLSTLLTMF	PEX5	621	P50542
LRDVLLSFVMSRNGS	FAM234B	161	A2RU67
RFSDAALVSMSVREL	NRL	131	P54845
FAFDLDARRLASMAT	NSUN5P2	71	Q63ZY6
ARMADGSTALILAAR	NOTCH3	1901	Q9UM47
AFRLASDGCLRALAM	KCNH1	581	O95259
SGDVSALRRFALSAM	GLS2	496	Q9UI32
CRRFTTDAIALAMSR	PSMB9	171	P28065
MAAVLLRRLLSSAFD	IPO5	61	O00410
LFTSSAMCRDAGRAL	MEI1	406	Q5TIA1
DMLAADLRCSLFASA	PARP16	16	Q8N5Y8
RMARRLLGADSATVF	PALLD	931	Q8WX93
MAAALRVAAVGARLS	PCCB	1	P05166
ADLRLPAAAMSSRNF	PCDHAC1	41	Q9H158
TLALFEFTDRRLEML	COG6	511	Q9Y2V7
LTARDMESVLRAFAA	CASP5	236	P51878
LLFDMAALRLSFSEI	GALNT5	26	Q7Z7M9
RRLADVSAVMDSFLT	FNDC11	161	Q9BVV2
EALMAALRQATAAAR	MARK4	671	Q96L34
MAAVRVLVASRLAAA	GATD3	1	P0DPI2
AMRSAINILLASLAF	GPR63	111	Q9BZJ6
LEISSMRRILDSAEF	GTF2I	921	P78347
RRATVASFLILAGLM	SLC22A20P	396	A6NK97
FMALDLASLASVRAF	DHRS13	91	Q6UX07
SRLTLSMAVAAEFRD	PURB	71	Q96QR8
VDFRNMASLRSLSLE	NRROS	456	Q86YC3
LSLVMRSARELYLSA	IER2	36	Q9BTL4
ASAELLLLTVMSFDR	OR14A16	106	Q8NHC5
VRASELRSFSRMLAG	KIF13B	1651	Q9NQT8
VAANALMSLLAVSRR	RTTN	1861	Q86VV8
LQEGATRLLRFAASM	SFI1	886	A8K8P3
LLLVAASAMVRSEAS	SELENOT	6	P62341
SMVIRDLTLRSAASF	RFX2	621	P48378
SMVIRDLTLRSAASF	RFX3	606	P48380
ASVRALLFDISFLML	MED24	486	O75448
LREMACISRSLAALA	KIF25	286	Q9UIL4
MARSATLAAAALALC	NPB	1	Q8NG41
LALALSARDRAMKES	SHANK2	1216	Q9UPX8
RALAALDAFALNMTR	CHST7	396	Q9NS84
MAASAAVFSRLRSGL	TIMM50	1	Q3ZCQ8
RLDEVMAAAALTSLS	SLC2A4RG	101	Q9NR83
MALSSRARAFSVEAL	TBX22	1	Q9Y458
ADLFVADQRSRMLSI	SPNS1	176	Q9H2V7
LARAANMALFRDSRV	TMEM121	231	Q9BTD3
NMALFRDSRVSAIFV	TMEM121	236	Q9BTD3
MAAAVAAALARLLAA	SPPL2B	1	Q8TCT7
MRSLRLFFSDEACTS	TBC1D16	306	Q8TBP0
LELDRLMASLSDFRV	TGFB1I1	156	O43294
LSFIERLVEMASSLA	TRRAP	2901	Q9Y4A5
RSAAMKLFTAIRDAL	KEL	436	P23276
MFFSAALRARAAGLT	NDUFV2	1	P19404