Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	P-type calcium transporter activity	ATP2A1 ATP2A2 ATP2A3	6.39e-06	11	69	3	GO:0005388
GeneOntologyMolecularFunction	calcium-dependent ATPase activity	ATP2A1 ATP2A3	7.03e-05	4	69	2	GO:0030899
GeneOntologyMolecularFunction	transporter activity	PIEZO2 KCNT2 SLC44A5 APOL4 SLC37A2 KCNK6 APOD TMEM184B ATP2A1 ATP2A2 ATP2A3 CHRFAM7A SLC30A10 SLC6A14	1.10e-04	1289	69	14	GO:0005215
GeneOntologyMolecularFunction	G protein-coupled receptor activity	VN1R3 OR5B3 OR4C16 OR13A1 OR4E2 OR1F2P OR1C1 GPR171 GPR101 OR4K3 HCRTR1	2.09e-04	884	69	11	GO:0004930
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP2A1 ATP2A2 ATP2A3	2.60e-04	36	69	3	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP2A1 ATP2A2 ATP2A3	2.60e-04	36	69	3	GO:0015662
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	PIEZO2 KCNT2 APOL4 KCNK6 ATP2A1 ATP2A2 ATP2A3 CHRFAM7A SLC30A10 SLC6A14	3.76e-04	793	69	10	GO:0015075
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	PIEZO2 KCNT2 KCNK6 ATP2A1 ATP2A2 ATP2A3 CHRFAM7A SLC30A10 SLC6A14	4.49e-04	664	69	9	GO:0008324
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	VN1R3 OR5B3 OR4C16 MFSD6 OR13A1 OR4E2 OR1F2P OR1C1 GPR171 GPR101 OR4K3 CHRFAM7A HCRTR1	6.55e-04	1353	69	13	GO:0004888
GeneOntologyMolecularFunction	transmembrane transporter activity	PIEZO2 KCNT2 SLC44A5 APOL4 SLC37A2 KCNK6 ATP2A1 ATP2A2 ATP2A3 CHRFAM7A SLC30A10 SLC6A14	6.60e-04	1180	69	12	GO:0022857
GeneOntologyMolecularFunction	olfactory receptor activity	OR5B3 OR4C16 OR13A1 OR4E2 OR1F2P OR1C1 OR4K3	7.08e-04	431	69	7	GO:0004984
GeneOntologyMolecularFunction	siRNA binding	AGO2 TLR9	7.60e-04	12	69	2	GO:0035197
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	KCNT2 KCNK6 ATP2A1 ATP2A2 ATP2A3 SLC30A10 SLC6A14	1.10e-03	465	69	7	GO:0046873
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	KCNT2 APOL4 SLC37A2 KCNK6 ATP2A1 ATP2A2 ATP2A3 SLC30A10 SLC6A14	1.15e-03	758	69	9	GO:0015318
GeneOntologyMolecularFunction	ATP-dependent activity	ERCC6 SPAST MYO3B ASCC3 ATP2A1 ATP2A2 ATP2A3 TOP2B	1.23e-03	614	69	8	GO:0140657
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC44A5 SLC37A2 ATP2A1 ATP2A2 ATP2A3 SLC30A10 SLC6A14	1.28e-03	477	69	7	GO:0022804
GeneOntologyMolecularFunction	ATPase-coupled monoatomic cation transmembrane transporter activity	ATP2A1 ATP2A2 ATP2A3	1.29e-03	62	69	3	GO:0019829
GeneOntologyMolecularFunction	adenylate cyclase binding	CHRFAM7A ADCY2	1.37e-03	16	69	2	GO:0008179
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	ATP2A1 ATP2A2 ATP2A3 SLC30A10	1.86e-03	151	69	4	GO:0015085
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	ATP2A1 ATP2A2 ATP2A3 SLC30A10 SLC6A14	3.85e-03	301	69	5	GO:0022853
GeneOntologyMolecularFunction	outward rectifier potassium channel activity	KCNT2 KCNK6	3.91e-03	27	69	2	GO:0015271
GeneOntologyMolecularFunction	ATP hydrolysis activity	ERCC6 SPAST ASCC3 ATP2A1 ATP2A2 ATP2A3	4.16e-03	441	69	6	GO:0016887
GeneOntologyMolecularFunction	peptide binding	DHCR24 GPR171 CHRFAM7A HCRTR1 BRAP	4.86e-03	318	69	5	GO:0042277
GeneOntologyBiologicalProcess	calcium ion transport from cytosol to endoplasmic reticulum	ATP2A2 ATP2A3	1.10e-05	2	69	2	GO:1903515
GeneOntologyBiologicalProcess	positive regulation of endoplasmic reticulum calcium ion concentration	ATP2A1 ATP2A2	3.30e-05	3	69	2	GO:0032470
GeneOntologyBiologicalProcess	cytosol to endoplasmic reticulum transport	ATP2A2 ATP2A3	1.10e-04	5	69	2	GO:0046967
GeneOntologyBiologicalProcess	endoplasmic reticulum calcium ion homeostasis	ATP2A1 ATP2A2 ATP2A3	1.23e-04	29	69	3	GO:0032469
GeneOntologyBiologicalProcess	regulation of cardiac conduction	ATP2A1 ATP2A2 ATP2A3	1.23e-04	29	69	3	GO:1903779
GeneOntologyCellularComponent	platelet dense tubular network membrane	ATP2A1 ATP2A2 ATP2A3	2.85e-06	9	69	3	GO:0031095
GeneOntologyCellularComponent	platelet dense tubular network	ATP2A1 ATP2A2 ATP2A3	5.57e-06	11	69	3	GO:0031094
GeneOntologyCellularComponent	sarcoplasmic reticulum	MTMR12 DMPK ATP2A1 ATP2A2 ATP2A3	1.07e-05	88	69	5	GO:0016529
GeneOntologyCellularComponent	sarcoplasmic reticulum membrane	DMPK ATP2A1 ATP2A2 ATP2A3	1.46e-05	45	69	4	GO:0033017
GeneOntologyCellularComponent	sarcoplasm	MTMR12 DMPK ATP2A1 ATP2A2 ATP2A3	3.76e-05	114	69	5	GO:0016528
HumanPheno	Uveitis	MST1 ERCC6 MBTPS2 UBAC2 LRBA	1.43e-05	64	26	5	HP:0000554
Domain	P-type_ATPase_IIA	ATP2A1 ATP2A2 ATP2A3	4.41e-08	3	67	3	IPR005782
Domain	Hydrolase_3	ATP2A1 ATP2A2 ATP2A3	5.20e-06	10	67	3	PF08282
Domain	-	ATP2A1 ATP2A2 ATP2A3	2.39e-05	16	67	3	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP2A1 ATP2A2 ATP2A3	2.39e-05	16	67	3	IPR023298
Domain	ATPase_P-typ_cation-transptr_C	ATP2A1 ATP2A2 ATP2A3	2.89e-05	17	67	3	IPR006068
Domain	Cation_ATPase_C	ATP2A1 ATP2A2 ATP2A3	2.89e-05	17	67	3	PF00689
Domain	Cation_ATPase_N	ATP2A1 ATP2A2 ATP2A3	3.46e-05	18	67	3	PF00690
Domain	Cation_ATPase_N	ATP2A1 ATP2A2 ATP2A3	3.46e-05	18	67	3	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP2A1 ATP2A2 ATP2A3	4.10e-05	19	67	3	IPR004014
Domain	G_PROTEIN_RECEP_F1_1	VN1R3 OR5B3 OR4C16 OR13A1 OR4E2 OR1F2P OR1C1 GPR171 GPR101 HCRTR1	1.55e-04	685	67	10	PS00237
Domain	G_PROTEIN_RECEP_F1_2	VN1R3 OR5B3 OR4C16 OR13A1 OR4E2 OR1F2P OR1C1 GPR171 GPR101 HCRTR1	1.66e-04	691	67	10	PS50262
Domain	GPCR_Rhodpsn	VN1R3 OR5B3 OR4C16 OR13A1 OR4E2 OR1F2P OR1C1 GPR171 GPR101 HCRTR1	1.68e-04	692	67	10	IPR000276
Domain	-	ATP2A1 ATP2A2 ATP2A3	2.03e-04	32	67	3	3.40.1110.10
Domain	-	ATP2A1 ATP2A2 ATP2A3	2.03e-04	32	67	3	2.70.150.10
Domain	ATPase_P-typ_cyto_domN	ATP2A1 ATP2A2 ATP2A3	2.66e-04	35	67	3	IPR023299
Domain	P_typ_ATPase	ATP2A1 ATP2A2 ATP2A3	2.89e-04	36	67	3	IPR001757
Domain	ATPase_P-typ_P_site	ATP2A1 ATP2A2 ATP2A3	2.89e-04	36	67	3	IPR018303
Domain	ATPASE_E1_E2	ATP2A1 ATP2A2 ATP2A3	2.89e-04	36	67	3	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP2A1 ATP2A2 ATP2A3	3.14e-04	37	67	3	IPR008250
Domain	E1-E2_ATPase	ATP2A1 ATP2A2 ATP2A3	3.14e-04	37	67	3	PF00122
Domain	PH-BEACH_dom	LRBA WDFY4	3.50e-04	8	67	2	IPR023362
Domain	-	LRBA WDFY4	3.50e-04	8	67	2	2.30.29.40
Domain	PH_BEACH	LRBA WDFY4	3.50e-04	8	67	2	PS51783
Domain	BEACH_dom	LRBA WDFY4	4.49e-04	9	67	2	IPR000409
Domain	BEACH	LRBA WDFY4	4.49e-04	9	67	2	PS50197
Domain	Beach	LRBA WDFY4	4.49e-04	9	67	2	PF02138
Domain	-	LRBA WDFY4	4.49e-04	9	67	2	1.10.1540.10
Domain	Beach	LRBA WDFY4	4.49e-04	9	67	2	SM01026
Domain	7tm_1	OR5B3 OR4C16 OR13A1 OR4E2 OR1F2P OR1C1 GPR171 GPR101 HCRTR1	6.69e-04	677	67	9	PF00001
Domain	K_chnl_dom	KCNT2 KCNK6	2.55e-03	21	67	2	IPR013099
Domain	Ion_trans_2	KCNT2 KCNK6	2.55e-03	21	67	2	PF07885
Domain	GPCR_Rhodpsn_7TM	OR5B3 OR4C16 OR13A1 OR4E2 OR1C1 GPR171 GPR101 HCRTR1	2.66e-03	670	67	8	IPR017452
Domain	Olfact_rcpt	OR5B3 OR4C16 OR13A1 OR4E2 OR1F2P OR1C1	2.83e-03	393	67	6	IPR000725
Domain	HAD-like_dom	ATP2A1 ATP2A2 ATP2A3	2.87e-03	79	67	3	IPR023214
Domain	ArfGap	SMAP1 SMAP2	4.84e-03	29	67	2	SM00105
Domain	ArfGap	SMAP1 SMAP2	4.84e-03	29	67	2	PF01412
Domain	ARFGAP	SMAP1 SMAP2	4.84e-03	29	67	2	PS50115
Domain	ArfGAP	SMAP1 SMAP2	4.84e-03	29	67	2	IPR001164
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_SERCA	ATP2A1 ATP2A2 ATP2A3	2.77e-06	8	53	3	M47955
Pathway	REACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS	ATP2A1 ATP2A2 ATP2A3	1.08e-05	12	53	3	M27326
Pathway	REACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS	ATP2A1 ATP2A2 ATP2A3	1.77e-05	14	53	3	MM15052
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI	ATP2A1 ATP2A2 ATP2A3	3.93e-05	18	53	3	M614
Pathway	REACTOME_CARDIAC_CONDUCTION	KCNK6 DMPK ATP2A1 ATP2A2 ATP2A3	4.10e-05	103	53	5	MM15196
Pathway	REACTOME_ION_HOMEOSTASIS	DMPK ATP2A1 ATP2A2 ATP2A3	4.90e-05	54	53	4	M27460
Pathway	REACTOME_ION_HOMEOSTASIS	DMPK ATP2A1 ATP2A2 ATP2A3	4.90e-05	54	53	4	MM15202
Pathway	REACTOME_CARDIAC_CONDUCTION	KCNK6 DMPK ATP2A1 ATP2A2 ATP2A3	1.24e-04	130	53	5	M27454
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ATP2A1 ATP2A2 ATP2A3	1.38e-04	27	53	3	MM15053
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ATP2A1 ATP2A2 ATP2A3	1.54e-04	28	53	3	M924
Pathway	REACTOME_MUSCLE_CONTRACTION	KCNK6 DMPK ATP2A1 ATP2A2 ATP2A3	3.77e-04	165	53	5	MM15026
Pathway	REACTOME_MUSCLE_CONTRACTION	KCNK6 DMPK ATP2A1 ATP2A2 ATP2A3	9.65e-04	203	53	5	M5485
Pathway	REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING	AGO2 ATP2A1 ATP2A2 ATP2A3	1.03e-03	119	53	4	M607
Pathway	REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES	ATP2A1 ATP2A2 ATP2A3	1.15e-03	55	53	3	M971
Pathway	REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES	ATP2A1 ATP2A2 ATP2A3	1.27e-03	57	53	3	MM15643
Pubmed	The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors.	ATP2A1 ATP2A2 ATP2A3	8.15e-09	3	71	3	16410239
Pubmed	The nongastric H+-K+-ATPases: molecular and functional properties.	ATP2A1 ATP2A2 ATP2A3	3.26e-08	4	71	3	10362770
Pubmed	Expression of sarco (endo) plasmic reticulum calcium ATPase (SERCA) system in normal mouse cardiovascular tissues, heart failure and atherosclerosis.	ATP2A1 ATP2A2 ATP2A3	3.26e-08	4	71	3	25110346
Pubmed	The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.	OSBPL1A ATP2A1 ATP2A2 ATP2A3	1.13e-07	22	71	4	28890335
Pubmed	Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1.	ATP2A1 ATP2A2 ATP2A3	2.84e-07	7	71	3	24786561
Pubmed	Gene knockout studies of Ca2+-transporting ATPases.	ATP2A1 ATP2A2 ATP2A3	4.53e-07	8	71	3	10951186
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	ATP2A1 ATP2A2 ATP2A3	4.53e-07	8	71	3	19033399
Pubmed	Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides.	ATP2A1 ATP2A2 ATP2A3	4.53e-07	8	71	3	27923914
Pubmed	A micropeptide encoded by a putative long noncoding RNA regulates muscle performance.	ATP2A1 ATP2A2 ATP2A3	6.79e-07	9	71	3	25640239
Pubmed	Targeted disruption of the ATP2A1 gene encoding the sarco(endo)plasmic reticulum Ca2+ ATPase isoform 1 (SERCA1) impairs diaphragm function and is lethal in neonatal mice.	ATP2A1 ATP2A2	4.11e-06	2	71	2	12556521
Pubmed	Regulation of SERCA pumps expression in diabetes.	ATP2A2 ATP2A3	4.11e-06	2	71	2	25270119
Pubmed	Atypical fast SERCA1a protein expression in slow myofibers and differential S-nitrosylation prevented by exercise during long term bed rest.	ATP2A1 ATP2A2	4.11e-06	2	71	2	19644701
Pubmed	Sarco(endo)plasmic reticulum Ca2+ ATPases (SERCA1 and -2) in human extraocular muscles.	ATP2A1 ATP2A2	4.11e-06	2	71	2	14638697
Pubmed	Sarco(endo)plasmic reticulum Ca2+ ATPase isoforms and their role in muscle physiology and pathology.	ATP2A1 ATP2A2	4.11e-06	2	71	2	10603953
Pubmed	Characterizing SERCA Function in Murine Skeletal Muscles after 35-37 Days of Spaceflight.	ATP2A1 ATP2A2	4.11e-06	2	71	2	34769190
Pubmed	Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2.	TLR9 ATP2A2	4.11e-06	2	71	2	24610369
Pubmed	Alterations in genes encoding sarcoplasmic-endoplasmic reticulum Ca(2+) pumps in association with head and neck squamous cell carcinoma.	ATP2A2 ATP2A3	4.11e-06	2	71	2	18295663
Pubmed	Modulation of B-cell endoplasmic reticulum calcium homeostasis by Epstein-Barr virus latent membrane protein-1.	ATP2A2 ATP2A3	4.11e-06	2	71	2	19650915
Pubmed	Training induced decrease in oxygen cost of cycling is accompanied by down-regulation of SERCA expression in human vastus lateralis muscle.	ATP2A1 ATP2A2	4.11e-06	2	71	2	18953100
Pubmed	SERCA overexpression reduces hydroxyl radical injury in murine myocardium.	ATP2A1 ATP2A2	4.11e-06	2	71	2	16798816
Pubmed	Mechanisms of control of the free Ca2+ concentration in the endoplasmic reticulum of mouse pancreatic β-cells: interplay with cell metabolism and [Ca2+]c and role of SERCA2b and SERCA3.	ATP2A2 ATP2A3	4.11e-06	2	71	2	21885870
Pubmed	Multiple and diverse coexpression, location, and regulation of additional SERCA2 and SERCA3 isoforms in nonfailing and failing human heart.	ATP2A2 ATP2A3	4.11e-06	2	71	2	19962989
Pubmed	The Arf GTPase-activating protein SMAP1 promotes transferrin receptor endocytosis and interacts with SMAP2.	SMAP1 SMAP2	4.11e-06	2	71	2	25281535
Pubmed	Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice.	TLR9 ATP2A2	4.11e-06	2	71	2	28490840
Pubmed	Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality.	SMAP1 SMAP2	4.11e-06	2	71	2	26296315
Pubmed	Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses.	ATP2A1 ATP2A2	4.11e-06	2	71	2	12975374
Pubmed	Effect of chronic obstructive pulmonary disease on calcium pump ATPase expression in human diaphragm.	ATP2A1 ATP2A2	4.11e-06	2	71	2	15718407
Pubmed	SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis.	ATP2A1 ATP2A2	4.11e-06	2	71	2	11402072
Pubmed	Calpain 3 deficiency affects SERCA expression and function in the skeletal muscle.	ATP2A1 ATP2A2	1.23e-05	3	71	2	27055500
Pubmed	Sarcoplasmic reticulum Ca2+ ATPase pump is a major regulator of glucose transport in the healthy and diabetic heart.	ATP2A1 ATP2A2	1.23e-05	3	71	2	25615793
Pubmed	Modulation of endoplasmic reticulum calcium pump by Bcl-2.	ATP2A2 ATP2A3	1.23e-05	3	71	2	9788433
Pubmed	Human platelet Ca2+-ATPases: new markers of cell differentiation as illustrated in idiopathic scoliosis.	ATP2A2 ATP2A3	1.23e-05	3	71	2	16973504
Pubmed	Alteration of RANKL-induced osteoclastogenesis in primary cultured osteoclasts from SERCA2+/- mice.	ATP2A2 ATP2A3	1.23e-05	3	71	2	19419309
Pubmed	Phospholamban domain IB forms an interaction site with the loop between transmembrane helices M6 and M7 of sarco(endo)plasmic reticulum Ca2+ ATPases.	ATP2A1 ATP2A2	1.23e-05	3	71	2	11526231
Pubmed	Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3.	ATP2A2 ATP2A3	1.23e-05	3	71	2	15161756
Pubmed	Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1.	ATP2A1 ATP2A2	1.23e-05	3	71	2	15972723
Pubmed	Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice.	TLR9 ATP2A2	1.23e-05	3	71	2	26461521
Pubmed	Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression.	ATP2A1 ATP2A2	1.23e-05	3	71	2	16754798
Pubmed	Coordinate regulation of SR Ca(2+)-ATPase and phospholamban expression in developing murine heart.	ATP2A1 ATP2A2	1.23e-05	3	71	2	9038922
Pubmed	Specific effects of endurance and sprint training on protein expression of calsequestrin and SERCA in mouse skeletal muscle.	ATP2A1 ATP2A2	1.23e-05	3	71	2	22466636
Pubmed	Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs).	ATP2A1 ATP2A2	2.46e-05	4	71	2	12032137
Pubmed	Lack of nitric oxide synthase depresses ion transporting enzyme function in cardiac muscle.	ATP2A1 ATP2A2	2.46e-05	4	71	2	12074580
Pubmed	Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart.	ATP2A1 ATP2A2	2.46e-05	4	71	2	9295312
Pubmed	SERCA1a can functionally substitute for SERCA2a in the heart.	ATP2A1 ATP2A2	2.46e-05	4	71	2	9887021
Pubmed	Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy.	ATP2A1 ATP2A2	2.46e-05	4	71	2	10555147
Pubmed	SERCA2b and 3 play a regulatory role in store-operated calcium entry in human platelets.	ATP2A2 ATP2A3	2.46e-05	4	71	2	18068335
Pubmed	Biology, structure and mechanism of P-type ATPases.	ATP2A1 ATP2A2 ATP2A3	2.87e-05	29	71	3	15071553
Pubmed	The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy.	ATP2A1 ATP2A2	4.09e-05	5	71	2	30299255
Pubmed	Five mucosal transcripts of interest in ulcerative colitis identified by quantitative real-time PCR: a prospective study.	MST1 SLC6A14	4.09e-05	5	71	2	18700007
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	NISCH ASCC3 DMPK ATP2A1 ATP2A2	6.00e-05	202	71	5	24639526
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	ATP2A1 ATP2A2 ATP2A3	6.53e-05	38	71	3	30786075
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	TRANK1 ERCC6 NCKAP1 PIK3C2B LRBA ASCC3 ATP2A3	7.05e-05	497	71	7	36774506
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	NCKAP1 WDR11 LRBA ASCC3 BRAP	8.23e-05	216	71	5	31519766
Pubmed	Genome-wide association study reveals two new risk loci for bipolar disorder.	TRANK1 ADCY2	1.14e-04	8	71	2	24618891
Pubmed	Early Developmental Disruption of Type 2 Deiodinase Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function.	ATP2A1 ATP2A2	1.14e-04	8	71	2	27967605
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	ATP2A1 ATP2A2	1.14e-04	8	71	2	11784029
Pubmed	The human olfactory receptor gene family.	OR5B3 OR4C16 OR13A1 OR4E2 OR1F2P OR1C1 OR4K3	1.19e-04	541	71	7	14983052
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	WDR11 LRBA ASCC3 TOP2B	1.45e-04	129	71	4	23022380
Pubmed	Identification of novel germline polymorphisms governing capecitabine sensitivity.	SLC44A5 ADCY2	1.47e-04	9	71	2	22864933
Pubmed	The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm.	ATP2A1 ATP2A2	1.47e-04	9	71	2	15253893
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MTMR12 NCKAP1 NISCH TET3 ADCY2 VPS13B	1.87e-04	407	71	6	12693553
Pubmed	The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis.	ATP2A1 ATP2A2	2.23e-04	11	71	2	12122109
Pubmed	Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2.	DHCR24 UBAC2 ATP2A2	2.97e-04	63	71	3	35993436
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	SMAP1 WDR11 DHCR24 LRBA SMAP2	2.99e-04	285	71	5	34369648
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	AGO2 PIK3C2B ASCC3 BRAP	4.06e-04	169	71	4	31462741
Pubmed	A gene-driven ENU-based approach to generating an allelic series in any gene.	SPAST NISCH	4.24e-04	15	71	2	15457338
Pubmed	Differentially expressed genes in the lens of mimecan-null mice.	APOD ATP2A1	5.48e-04	17	71	2	15215744
Pubmed	Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation.	ATP2A1 ATP2A2	5.48e-04	17	71	2	22411552
Pubmed	Genome-wide association of mood-incongruent psychotic bipolar disorder.	TRANK1 LRBA	6.16e-04	18	71	2	23092984
Pubmed	Non conservation of function for the evolutionarily conserved prdm1 protein in the control of the slow twitch myogenic program in the mouse embryo.	ATP2A1 ATP2A2	6.16e-04	18	71	2	22522309
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR5B3 OR4C16 OR13A1 OR4E2 OR1F2P	6.66e-04	340	71	5	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR5B3 OR4C16 OR13A1 OR4E2 OR1F2P	6.66e-04	340	71	5	11802173
Pubmed	Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.	SGSM3 TMEM184B	6.87e-04	19	71	2	25342443
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR5B3 OR4C16 OR13A1 OR4E2 OR1F2P	6.93e-04	343	71	5	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR5B3 OR4C16 OR13A1 OR4E2 OR1F2P	7.20e-04	346	71	5	14611657
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	AGO2 TRANK1 SPAST INTS2 DHCR24 IGSF1	7.47e-04	529	71	6	14621295
Pubmed	Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype.	ATP2A1 ATP2A2	7.62e-04	20	71	2	18978355
Pubmed	Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling.	ATP2A1 ATP2A2	9.24e-04	22	71	2	35081489
Pubmed	Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia.	PIK3C2B TLR9	1.01e-03	23	71	2	19047410
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR4E2 OR1F2P OR1C1 OR4K3	1.07e-03	219	71	4	12213199
Pubmed	Widespread and dynamic translational control of red blood cell development.	MAN2C1 SLC44A5 INTS2	1.21e-03	102	71	3	27899360
Pubmed	Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.	TRANK1 NISCH TLR9	1.21e-03	102	71	3	21926972
Pubmed	Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.	NCKAP1 PIK3C2B NISCH	1.25e-03	103	71	3	21706016
Pubmed	TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation.	UBAC2 ATP2A2	1.29e-03	26	71	2	35961308
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	PIK3C2B UBAC2 RHBDD3 ASCC3 TOP2B BRAP	1.47e-03	604	71	6	38803224
Pubmed	Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2.	ATP2A1 ATP2A2	1.84e-03	31	71	2	16140986
Cytoband	10q11.23	ERCC6 WDFY4	1.21e-03	33	71	2	10q11.23
GeneFamily	ATPases Ca2+ transporting	ATP2A1 ATP2A2 ATP2A3	1.86e-06	9	52	3	1209
GeneFamily	WD repeat domain containing\|BEACH domain containing	LRBA WDFY4	2.88e-04	9	52	2	1230
GeneFamily	Rhomboid family	UBAC2 RHBDD3	7.22e-04	14	52	2	926
GeneFamily	Apolipoproteins	APOL4 APOD	1.65e-03	21	52	2	405
GeneFamily	ArfGAPs	SMAP1 SMAP2	4.05e-03	33	52	2	395
GeneFamily	Olfactory receptors, family 1	OR1F2P OR1C1	5.90e-03	40	52	2	147
GeneFamily	Olfactory receptors, family 4	OR4C16 OR4E2 OR4K3	6.08e-03	129	52	3	151
GeneFamily	WD repeat domain containing	WDR11 WDR27 LRBA WDFY4	6.77e-03	262	52	4	362
ToppCell	droplet-Lung-LUNG-1m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC37A2 GPR171 TLR9 APOD ATP2A1	6.42e-06	166	70	5	6e6075d0c913e2516083f6dcab21d5878bcef7a4
ToppCell	droplet-Lung-1m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC37A2 GPR171 TLR9 APOD ATP2A1	6.42e-06	166	70	5	1ca888ae8168707493f19ee52a89d7c70e6cb51d
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC37A2 GPR171 TLR9 APOD ATP2A1	6.42e-06	166	70	5	4fbe44e0aea197893614cd55f83119aa0f73ee53
ToppCell	droplet-Lung-1m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC37A2 GPR171 TLR9 APOD ATP2A1	6.42e-06	166	70	5	4cba4ca1aa2321b9ef7cd230932b890d2434a252
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PIEZO2 DHCR24 MFSD6 OSBPL1A APOD	1.30e-05	192	70	5	8dc3016601148243196e925641c9507e9d58c9e0
Drug	alpha-naphthylthiourea	APOL4 DMPK ATP2A1 ATP2A2 ATP2A3 CHRFAM7A	2.09e-07	84	69	6	CID000736366
Drug	verapamil	KCNT2 MYO3B KCNK6 APOD ATP2A1 ATP2A2 ATP2A3 CHRFAM7A ADCY2 TOP2B	2.12e-06	490	69	10	CID000002520
Drug	ATP-EDC	ATP2A1 ATP2A2 ATP2A3	3.15e-06	10	69	3	CID000195647
Drug	1sqc	ATP2A1 ATP2A2 ATP2A3	3.15e-06	10	69	3	CID000444279
Drug	2,5-dimethylquinone	ATP2A1 ATP2A2 ATP2A3	4.32e-06	11	69	3	CID000008718
Drug	PST-2744	ATP2A1 ATP2A3 BRAP	5.75e-06	12	69	3	CID009841834
Drug	1vyq	ATP2A1 ATP2A2 ATP2A3	5.75e-06	12	69	3	CID004369390
Drug	p-hydroxyhippuric acid	ATP2A1 ATP2A2 ATP2A3	9.47e-06	14	69	3	CID000151012
Drug	NSC239129	ATP2A1 ATP2A2 ATP2A3	1.18e-05	15	69	3	CID000084597
Drug	AC1L88YH	ATP2A1 ATP2A2 ATP2A3	1.76e-05	17	69	3	CID000374551
Drug	acetazolamide	DMPK ATP2A1 ATP2A2 ATP2A3 BRAP	1.85e-05	107	69	5	CID000001986
Drug	cisapride	DMPK ATP2A1 ATP2A2 ATP2A3 ADCY2	2.30e-05	112	69	5	CID000002769
Drug	AC1L380G	ATP2A1 ATP2A2 ATP2A3	2.49e-05	19	69	3	CID000084698
Drug	methyl phosphate	DMPK ATP2A1 ATP2A3	2.93e-05	20	69	3	CID000013130
Drug	CC270	DMPK ATP2A1 ATP2A2 ATP2A3	3.10e-05	59	69	4	CID006918852
Drug	nsc25485	PIK3C2B ATP2A1 ATP2A2 ATP2A3 ADCY2 TOP2B ITFG1	4.42e-05	312	69	7	CID000004605
Drug	AC1L25Y6	ATP2A1 ATP2A2 ATP2A3	4.52e-05	23	69	3	CID000015465
Drug	lanthanum chloride hydrate	ATP2A1 ATP2A2 ATP2A3	4.52e-05	23	69	3	CID000165791
Drug	propranolol	ERCC6 APOD LRBA DMPK ATP2A1 ATP2A3 CHRFAM7A ADCY2	4.94e-05	434	69	8	CID000004946
Drug	quindine	KCNK6 DMPK ATP2A1 ATP2A2 ATP2A3 CHRFAM7A	5.35e-05	219	69	6	CID000001065
Drug	trifluoperazine	MYO3B LRBA ATP2A1 ATP2A2 ATP2A3 CHRFAM7A ADCY2	5.61e-05	324	69	7	CID000005566
Drug	EUK-8	ATP2A1 ATP2A2 ATP2A3	5.84e-05	25	69	3	CID000171249
Drug	cyhexatin	ATP2A1 ATP2A2 ATP2A3	5.84e-05	25	69	3	CID005364545
Drug	Pyrethroids	DMPK ATP2A1 ATP2A2 ATP2A3	6.44e-05	71	69	4	CID000005053
Drug	dodecyl ether	ATP2A1 ATP2A2 ATP2A3	6.59e-05	26	69	3	CID000020667
Drug	monobromobimane	APOD ATP2A1 ATP2A2 ATP2A3	6.80e-05	72	69	4	CID000114810
Drug	octaethylene glycol	ATP2A1 ATP2A2 ATP2A3	9.20e-05	29	69	3	CID000078798
Drug	Bay K 8644	LRBA DMPK ATP2A1 ATP2A2 ATP2A3	9.29e-05	150	69	5	CID000002303
Drug	DCCD	LRBA ATP2A1 ATP2A2 ATP2A3 ADCY2	9.59e-05	151	69	5	CID000010868
Drug	I-Q-S	LRBA DMPK ATP2A1 ATP2A2 ATP2A3	1.12e-04	156	69	5	CID000003540
Drug	epicholesterol	MBTPS2 DHCR24 APOL4 APOD ATP2A1 ATP2A2 ATP2A3 CHRFAM7A ADCY2	1.24e-04	636	69	9	CID000000304
Drug	calmidazolium chloride	LRBA ATP2A1 ATP2A2 ATP2A3 ADCY2	1.26e-04	160	69	5	CID000002531
Drug	2-(aminomethyl)pyrrolidine	LRBA ATP2A1 ATP2A2 ATP2A3 ADCY2	1.30e-04	161	69	5	CID000072032
Drug	BE-10988	DMPK TOP2B	1.35e-04	6	69	2	CID000126200
Drug	xenon	ATP2A1 ATP2A2 ATP2A3 BRAP	1.49e-04	88	69	4	CID000023991
Drug	fluorescamine	ATP2A1 ATP2A2 ATP2A3	1.63e-04	35	69	3	CID000037927
Drug	RA-V	ATP2A1 ATP2A2 ATP2A3	1.63e-04	35	69	3	CID000476891
Drug	AC1L1IIA	DMPK ATP2A1 ATP2A2 ATP2A3 TOP2B	1.77e-04	172	69	5	CID000004591
Drug	mag-fura-2	ATP2A1 ATP2A2 ATP2A3	1.92e-04	37	69	3	CID000123839
Drug	gramicidin s	ATP2A1 ATP2A2 ATP2A3	1.92e-04	37	69	3	CID000073357
Drug	potassium	KCNT2 PIK3C2B KCNK6 LRBA DMPK ATP2A1 ATP2A2 ATP2A3 CHRFAM7A ADCY2 BRAP	2.10e-04	1008	69	11	CID000000813
Disease	Brody myopathy (implicated_via_orthology)	ATP2A1 ATP2A2 ATP2A3	1.07e-08	3	66	3	DOID:0050692 (implicated_via_orthology)
Disease	Central hypothyroidism	IGSF1 SLC30A10	2.95e-05	4	66	2	C0271801
Disease	heart disease (implicated_via_orthology)	ATP2A1 ATP2A2 ATP2A3	8.53e-05	38	66	3	DOID:114 (implicated_via_orthology)
Disease	Motor retardation	ERCC6 HACE1	1.76e-04	9	66	2	C0424230
Disease	outer ear morphology trait	MYO3B LRBA	3.21e-04	12	66	2	EFO_0007664
Disease	Malignant neoplasm of breast	MST1 ERCC6 SPAST MAN2C1 KCNT2 NISCH LRBA ATP2A3 VPS13B	6.23e-04	1074	66	9	C0006142
Disease	Myeloid Leukemia	AGO2 TOP2B	7.37e-04	18	66	2	C0023470
Disease	Leukemia, Monocytic, Chronic	AGO2 TOP2B	7.37e-04	18	66	2	C0023466
Disease	glucose homeostasis measurement, acute insulin response measurement	ATP2A2 ATP2A3	7.37e-04	18	66	2	EFO_0006831, EFO_0006896
Disease	dense area measurement, mammographic density measurement	SGSM3 TMEM184B	8.22e-04	19	66	2	EFO_0005941, EFO_0006503

Protein segments in the cluster

Peptide	Gene	Start	Entry
CIIQLFHVDFAWILA	APOD	136	P05090
GVQENLWICLICGHI	BRAP	321	Q7Z569
LLKIFVVCIWVQQNH	APOL4	6	Q9BPW4
ALLCQFGTVQHVWKV	CD177	21	Q8N6Q3
LICVAVWLINIGHFN	ATP2A1	266	O14983
VICVAVWVINIGHFA	ATP2A3	266	Q93084
QFHTGIEIKVWAIAC	AGO2	441	Q9UKV8
WHLVALLGVVVTVCF	KCNK6	171	Q9Y257
LFCFELVLQNAWQLH	ERCC6	956	P0DP91
NLLVLCLFLVWQVRH	C22orf46	41	C9J442
SWVFLVVILQGVQCE	IGHV3-72	6	A0A0B4J1Y9
VFLLFLDCVWQLVHQ	MTMR12	451	Q9C0I1
LTCLGLVVFNWKLHQ	LRRC53	306	A6NM62
QLACLLEWGQTFVFH	KIAA1109	931	Q2LD37
CVGLVILSWIVGIFH	OR4K3	141	Q96R72
LGIIVLIFWDSCLHN	OR5B3	41	Q8NH48
WHLLTNFICVAIFLN	GPR171	176	O14626
ICNNEGLTAIHWLAV	HACE1	126	Q8IYU2
LLHVRNGAWFLCLLV	INTS2	201	Q9H0H0
IQVVFGHWDVVTCLA	LRBA	2631	P50851
NLFVPVFLNCWLAKH	KCNT2	161	Q6UVM3
ITIIIWLFFLQCCIH	GPR101	436	Q96P66
VLQGVTHAAIWAACI	MFSD6	541	Q6ZSS7
CVHNIIVGKLWIEQY	OSBPL1A	711	Q9BXW6
QFQLLIQHLWIAANC	CHRFAM7A	11	Q494W8
CIGLVAHAGQLTAVW	DMPK	606	Q09013
WIIFGFILCHGILNT	NCKAP1	261	Q9Y2A7
IHQLCALLVTGSWVV	OR1F2P	136	Q96R84
FHLIVWDQQICFPVQ	PIK3C2B	681	O00750
LVGNTLVCLAVWRNH	HCRTR1	61	O43613
HELWYFVVIQVCNGL	SLC37A2	141	Q8TED4
HLVWQILANVIIFIC	ADCY2	186	Q08462
LICIAVWIINIGHFN	ATP2A2	266	P16615
CNVNILCHGWLQDLV	IGSF1	146	Q8N6C5
VLIHQRWVFVCLFLL	DHCR24	26	Q15392
QLCTWVGELFLELHN	MAN2C1	506	Q9NTJ4
QQLRIFCAGIWHNFV	MBTPS2	216	O43462
WLINFVIALGQCALA	SLC44A5	466	Q8NCS7
ACFTHNCWVLEGIII	MST1	666	P26927
CVQLVAGLWLVTYLH	OR1C1	141	Q15619
VWLLCAVNTAIHTGL	OR13A1	166	Q8NGR1
AWVGSCVHSLVQIFL	OR4C16	146	Q8NGL9
LGLIQQHQHLCVFWT	OAS3	256	Q9Y6K5
QVKNHIWVFINCLIE	TOP2B	376	Q02880
GFFVWTALLITCHQI	TMEM184B	51	Q9Y519
CGLLRFQHLQAWETV	NPHP3	816	Q7Z494
SLICVGLNEQVLHLW	SGSM3	656	Q96HU1
GLNEQVLHLWLEVLC	SGSM3	661	Q96HU1
LVAFHLGLLFVWLCQ	SPAST	66	Q9UBP0
WLGAEAVCIINFQHL	ASCC3	1276	Q8N3C0
VGWQQECHLGTLRFL	RHBDD3	76	Q9Y3P4
VNVVGLLIFQDCAAW	SLC30A10	126	Q6XR72
CIQLVFALWLGGTVH	OR4E2	141	Q8NGC2
WNIGVFICIRCAGIH	SMAP2	41	Q8WU79
ELQPHGLVNCNWLFL	TLR9	36	Q9NR96
CVFWLNIAAALIQIL	STUM	91	Q69YW2
RILKVLWCFLIHVQG	NISCH	706	Q9Y2I1
LWCFLIHVQGSIRQF	NISCH	711	Q9Y2I1
IGTLVHNSCWLIQAF	PIEZO2	1371	Q9H5I5
LLACGQWHHLAVVVT	WDFY4	1156	Q6ZS81
WNIGVFICIRCAGIH	SMAP1	46	Q8IYB5
AQVWLEQVCAHLGLG	NAPRT	246	Q6XQN6
CQNAVIVILILAWEG	TET3	916	O43151
GLLQVFWGQEHLNCL	VPS13B	2241	Q7Z7G8
HAVKNDFQIWRLICG	UBAC2	46	Q8NBM4
QWLACGLANHLLLVF	WDR27	526	A2RRH5
GVCVFILAIIGILHW	ITFG1	576	Q8TB96
FIHCGVVLARLWKNV	TRANK1	2416	O15050
WQGLIAYGCHSLVVV	WDR11	31	Q9BZH6
CWILNTLVNITVLLH	VN1R3	136	Q9BXE9
LGLVCVTQAGIYWVH	SLC6A14	461	Q9UN76
LLLCLNLFVAQVHWH	TMEM202	166	A6NGA9
LCQFLIVATNGLWEV	PP2D1	446	A8MPX8
EVGFLFHCWVRLINL	GARIN5B	141	Q8N5Q1
HCVGGQLWLVLELCN	MYO3B	96	Q8WXR4