Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmetalloendopeptidase activity

ADAM8 ADAMTS2 ADAMTSL2

4.42e-04120253GO:0004222
GeneOntologyMolecularFunctionheparan sulfate proteoglycan binding

CFH APP

5.98e-0429252GO:0043395
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

CHD3 CHD5

9.76e-0437252GO:0140658
GeneOntologyMolecularFunctionpeptidase activity

ADAM8 ADAMTS2 UNC5CL USP19 ADAMTSL2

1.14e-03654255GO:0008233
GeneOntologyBiologicalProcessextracellular matrix organization

APP ADAMTSL3 ADAM8 ADAMTS2 ADAMTSL2 WDR72

4.73e-06377256GO:0030198
GeneOntologyBiologicalProcessextracellular structure organization

APP ADAMTSL3 ADAM8 ADAMTS2 ADAMTSL2 WDR72

4.80e-06378256GO:0043062
GeneOntologyBiologicalProcessexternal encapsulating structure organization

APP ADAMTSL3 ADAM8 ADAMTS2 ADAMTSL2 WDR72

4.88e-06379256GO:0045229
GeneOntologyBiologicalProcessregulation of protein catabolic process

APP PHF20L1 ADAM8 USP19 SORL1

1.12e-04407255GO:0042176
GeneOntologyBiologicalProcessprotein import

APP WDR72

1.67e-0416252GO:0017038
GeneOntologyBiologicalProcesspositive regulation of membrane protein ectodomain proteolysis

APP ADAM8

1.90e-0417252GO:0051044
GeneOntologyBiologicalProcessleukocyte aggregation

CFH ADAM8

2.38e-0419252GO:0070486
GeneOntologyBiologicalProcesscellular response to cold

SAXO1 TRPA1

2.38e-0419252GO:0070417
GeneOntologyBiologicalProcessprotein catabolic process

RNF130 ARIH1 APP PHF20L1 ADAM8 USP19 SORL1

2.69e-041115257GO:0030163
GeneOntologyCellularComponentnuclear envelope lumen

APP SORL1

1.24e-0414252GO:0005641
GeneOntologyCellularComponentCHD-type complex

CHD3 CHD5

1.85e-0417252GO:0090545
GeneOntologyCellularComponentNuRD complex

CHD3 CHD5

1.85e-0417252GO:0016581
HumanPhenoAphasia

CFH APP ADAMTS2 ADAMTSL2 SORL1

1.35e-06104115HP:0002381
HumanPhenoSemantic dementia

APP SORL1

8.85e-057112HP:0030219
HumanPhenoFinger agnosia

APP SORL1

8.85e-057112HP:0010525
HumanPhenoDeposits immunoreactive to beta-amyloid protein

APP SORL1

1.51e-049112HP:0003791
MousePhenoamyloid beta deposits

CFH APP SORL1

2.27e-0617223MP:0003329
MousePhenoamyloidosis

CFH APP SORL1

2.14e-0535223MP:0000604
MousePhenoabnormal amyloid deposition

CFH APP SORL1

2.14e-0535223MP:0021152
MousePhenonervous system inclusion bodies

CFH APP SORL1

3.73e-0542223MP:0014062
DomainPLAC

ADAMTSL3 ADAMTS2 ADAMTSL2

2.02e-0619253IPR010909
DomainPLAC

ADAMTSL3 ADAMTS2 ADAMTSL2

2.02e-0619253PS50900
DomainPeptidase_M12B_ADAM-TS

ADAMTSL3 ADAMTS2 ADAMTSL2

4.21e-0624253IPR013273
DomainCHDCT2

CHD3 CHD5

5.16e-063252PF08074
DomainCHDNT

CHD3 CHD5

5.16e-063252PF08073
DomainDUF1086

CHD3 CHD5

5.16e-063252IPR009462
DomainDUF1087

CHD3 CHD5

5.16e-063252IPR009463
DomainDUF1087

CHD3 CHD5

5.16e-063252PF06465
DomainDUF1086

CHD3 CHD5

5.16e-063252PF06461
DomainDUF1087

CHD3 CHD5

5.16e-063252SM01147
DomainDUF1086

CHD3 CHD5

5.16e-063252SM01146
DomainCHD_N

CHD3 CHD5

5.16e-063252IPR012958
DomainCHD_C2

CHD3 CHD5

5.16e-063252IPR012957
DomainTSP_1

ADAMTSL3 ADAMTS2 ADAMTSL2

7.98e-0563253PF00090
DomainZinc_finger_PHD-type_CS

CHD3 PHF20L1 CHD5

8.76e-0565253IPR019786
DomainTSP1

ADAMTSL3 ADAMTS2 ADAMTSL2

8.76e-0565253SM00209
DomainTSP1_rpt

ADAMTSL3 ADAMTS2 ADAMTSL2

8.76e-0565253IPR000884
DomainTSP1

ADAMTSL3 ADAMTS2 ADAMTSL2

8.76e-0565253PS50092
DomainPLAC

ADAMTSL3 ADAMTSL2

1.55e-0414252PF08686
DomainZF_PHD_1

CHD3 PHF20L1 CHD5

2.79e-0496253PS01359
Domain-

RNF130 CHD3 ARIH1 PHF20L1 CHD5

2.80e-044492553.30.40.10
DomainZnf_RING/FYVE/PHD

RNF130 CHD3 ARIH1 PHF20L1 CHD5

3.10e-04459255IPR013083
DomainADAM_spacer1

ADAMTS2 ADAMTSL2

4.28e-0423252IPR010294
DomainADAM_spacer1

ADAMTS2 ADAMTSL2

4.28e-0423252PF05986
DomainChromo_domain

CHD3 CHD5

4.66e-0424252IPR023780
DomainChromo

CHD3 CHD5

5.48e-0426252PF00385
DomainCHROMO_2

CHD3 CHD5

6.36e-0428252PS50013
DomainCHROMO_1

CHD3 CHD5

6.36e-0428252PS00598
DomainRING

RNF130 CHD3 ARIH1 CHD5

6.73e-04305254SM00184
DomainSNF2_N

CHD3 CHD5

8.32e-0432252PF00176
DomainSNF2_N

CHD3 CHD5

8.32e-0432252IPR000330
DomainChromodomain-like

CHD3 CHD5

8.32e-0432252IPR016197
DomainZnf_RING

RNF130 CHD3 ARIH1 CHD5

8.63e-04326254IPR001841
DomainCHROMO

CHD3 CHD5

8.85e-0433252SM00298
DomainChromo/shadow_dom

CHD3 CHD5

8.85e-0433252IPR000953
DomainZnf_FYVE_PHD

CHD3 PHF20L1 CHD5

9.68e-04147253IPR011011
DomainDNA/RNA_helicase_DEAH_CS

CHD3 CHD5

9.96e-0435252IPR002464
DomainDEAH_ATP_HELICASE

CHD3 CHD5

1.17e-0338252PS00690
DomainPeptidase_M12B_N

ADAM8 ADAMTS2

1.24e-0339252IPR002870
DomainPep_M12B_propep

ADAM8 ADAMTS2

1.24e-0339252PF01562
DomainDISINTEGRIN_1

ADAM8 ADAMTS2

1.30e-0340252PS00427
DomainADAM_MEPRO

ADAM8 ADAMTS2

1.30e-0340252PS50215
DomainDISINTEGRIN_2

ADAM8 ADAMTS2

1.30e-0340252PS50214
DomainReprolysin

ADAM8 ADAMTS2

1.30e-0340252PF01421
DomainPeptidase_M12B

ADAM8 ADAMTS2

1.30e-0340252IPR001590
DomainDisintegrin_dom

ADAM8 ADAMTS2

1.37e-0341252IPR001762
Domain-

CHD3 CHD5

2.45e-03552521.10.30.10
DomainEGF_extracell

ADAM8 JAG1

2.90e-0360252IPR013111
DomainEGF_2

ADAM8 JAG1

2.90e-0360252PF07974
DomainHMG_box_dom

CHD3 CHD5

3.40e-0365252IPR009071
DomainEGF_3

ADAM8 JAG1 SORL1

3.69e-03235253PS50026
DomainEGF

ADAM8 JAG1 SORL1

3.69e-03235253SM00181
DomainEGF-like_dom

ADAM8 JAG1 SORL1

4.34e-03249253IPR000742
DomainPHD

CHD3 CHD5

4.50e-0375252PF00628
DomainEGF-like_CS

ADAM8 JAG1 SORL1

4.94e-03261253IPR013032
DomainZnf_PHD-finger

CHD3 CHD5

4.98e-0379252IPR019787
DomainEGF_2

ADAM8 JAG1 SORL1

5.16e-03265253PS01186
DomainMetalloPept_cat_dom

ADAM8 ADAMTS2

5.22e-0381252IPR024079
Domain-

ADAM8 ADAMTS2

5.22e-03812523.40.390.10
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTSL3 ADAMTS2 ADAMTSL2

2.16e-0539203M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTSL3 ADAMTS2 ADAMTSL2

2.16e-0539203MM15165
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTSL3 ADAMTS2 ADAMTSL2

1.15e-0468203M27303
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTSL3 ADAMTS2 ADAMTSL2

4.66e-04109203MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTSL3 ADAMTS2 ADAMTSL2

4.91e-04111203M27416
Pubmed

Sortilin-related receptor 1 interacts with amyloid precursor protein and is activated by 6-shogaol, leading to inhibition of the amyloidogenic pathway.

APP SORL1

4.96e-07225228188785
Pubmed

Structural basis for amyloidogenic peptide recognition by sorLA.

APP SORL1

4.96e-07225225643321
Pubmed

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease.

APP SORL1

4.96e-07225221989385
Pubmed

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

APP SORL1

4.96e-07225216174740
Pubmed

Potentially Pathogenic SORL1 Mutations Observed in Autosomal-Dominant Cases of Alzheimer's Disease Do Not Modulate APP Physiopathological Processing.

APP SORL1

4.96e-07225238132122
Pubmed

Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.

APP SORL1

4.96e-07225216489755
Pubmed

Genetic deletion of TRPA1 receptor attenuates amyloid beta- 1-42 (Aβ1-42)-induced neurotoxicity in the mouse basal forebrain in vivo.

TRPA1 APP

4.96e-07225232473171
Pubmed

Mutants of metal binding site M1 in APP E2 show metal specific differences in binding of heparin but not of sorLA.

APP SORL1

4.96e-07225225835329
Pubmed

Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production.

APP SORL1

1.49e-06325221147781
Pubmed

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.

APP SORL1

1.49e-06325216407538
Pubmed

An intronic ncRNA-dependent regulation of SORL1 expression affecting Aβ formation is upregulated in post-mortem Alzheimer's disease brain samples.

APP SORL1

1.49e-06325222996644
Pubmed

GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production.

APP SORL1

1.49e-06325222621900
Pubmed

Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression.

APP SORL1

1.49e-06325220007471
Pubmed

α(2A) adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction.

APP SORL1

1.49e-06325225404298
Pubmed

Sortilin and SorLA regulate neuronal sorting of trophic and dementia-linked proteins.

APP SORL1

1.49e-06325222297619
Pubmed

Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.

APP SORL1

1.49e-06325228799085
Pubmed

ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases.

ADAMTSL3 ADAMTSL2

1.49e-06325214667842
Pubmed

Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein.

APP SORL1

1.49e-06325223283322
Pubmed

Innate immunity of the ocular surface and ocular surface inflammatory disorders.

NFKBIZ IL4R

2.97e-06425218813073
Pubmed

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.

APP SORL1

2.97e-06425217855360
Pubmed

Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch.

TRPA1 IL4R

2.97e-06425228890086
Pubmed

A Jagged 1-Notch 4 molecular switch mediates airway inflammation induced by ultrafine particles.

IL4R JAG1

7.43e-06625229627423
Pubmed

Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells.

CFH APP

7.43e-06625221640790
Pubmed

Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade.

IL4R JAG1

1.39e-05825225825216
Pubmed

Mapping genetic modulators of amyloid plaque deposition in TgCRND8 transgenic mice.

RNF130 APP

1.39e-05825216785251
Pubmed

Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis.

APP SORL1

1.78e-05925232601248
Pubmed

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.

APP SORL1

1.78e-05925220005821
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTSL3 ADAMTS2 ADAMTSL2

2.14e-057525320637190
Pubmed

DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression.

CHD3 CHD5

5.18e-051525235695185
Pubmed

A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development.

CHD3 CHD5

6.70e-051725227806305
Pubmed

Myocardial Angiopoietin-1 Controls Atrial Chamber Morphogenesis by Spatiotemporal Degradation of Cardiac Jelly.

ADAMTS2 JAG1

1.36e-042425229791855
Pubmed

Identification of the BRD1 interaction network and its impact on mental disorder risk.

CHD3 CHD5

2.91e-043525227142060
Pubmed

Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin.

ADAM8 ADAMTS2

2.91e-043525216452166
Pubmed

Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

CHD3 CHD5

3.43e-043825233283408
Pubmed

Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

RNF130 EDC4

3.62e-043925221347282
Pubmed

The Type 3 Deiodinase Is a Critical Modulator of Thyroid Hormone Sensitivity in the Fetal Brain.

ADAMTS2 SORL1

4.82e-044525234248495
Pubmed

Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia.

ADAM8 JAG1

5.48e-044825235247391
InteractionBCL11A interactions

CHD3 APP PHF20L1 CHD5

7.21e-06102254int:BCL11A
InteractionTCEANC2 interactions

CFH ARIH1 APP

9.84e-0634253int:TCEANC2
InteractionCDK2AP2 interactions

CHD3 APP CHD5

2.99e-0549253int:CDK2AP2
CytobandEnsembl 112 genes in cytogenetic band chr5q35

RNF130 ADAMTS2

7.24e-03235252chr5q35
GeneFamilyADAMTS like

ADAMTSL3 ADAMTSL2

2.69e-057212947
GeneFamilyPHD finger proteins|NuRD complex

CHD3 CHD5

8.42e-05122121305
GeneFamilyPHD finger proteins

CHD3 PHF20L1 CHD5

1.49e-049021388
CoexpressionGSE4142_NAIVE_BCELL_VS_PLASMA_CELL_UP

RNF130 APP PHF20L1 TBC1D8B

3.60e-05199254M6381
CoexpressionGSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP

MRPS18A CFH NFKBIZ SORL1

3.67e-05200254M9696
CoexpressionSESTO_RESPONSE_TO_UV_C8

APP IL4R SORL1

4.20e-0571253M2948
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_ADVENTITIAL_FIBROBLAST

CFH PDIA5 ADAMTSL3

4.20e-0571253M45664
CoexpressionSASAKI_TARGETS_OF_TP73_AND_TP63

IL4R JAG1

5.73e-0512252M17374
CoexpressionNABA_ECM_REGULATORS

ADAMTSL3 ADAM8 ADAMTS2 ADAMTSL2

7.22e-05238254M3468
CoexpressionKIM_GLIS2_TARGETS_UP

CFH ADAM8 ADAMTS2

7.44e-0586253M2259
CoexpressionNABA_ECM_REGULATORS

ADAMTSL3 ADAM8 ADAMTS2 ADAMTSL2

7.70e-05242254MM17062
CoexpressionLU_IL4_SIGNALING

NFKBIZ PHF20L1 IL4R

8.81e-0591253M10558
CoexpressionKIM_GLIS2_TARGETS_UP

CFH ADAM8 ADAMTS2

1.24e-04102253MM1064
CoexpressionMURARO_PANCREAS_DUCTAL_CELL

CFH PDIA5 NFKBIZ APP IL4R JAG1 WDR72

1.41e-041276257M39173
CoexpressionAZARE_NEOPLASTIC_TRANSFORMATION_BY_STAT3_UP

CFH JAG1 SORL1

2.31e-04126253M2309
CoexpressionDESCARTES_MAIN_FETAL_PDE1C_ACSM3_POSITIVE_CELLS

ZBTB26 ARIH1 USP19 ADAMTSL2

3.56e-04361254M40141
CoexpressionBOSCO_ALLERGEN_INDUCED_TH2_ASSOCIATED_MODULE

NFKBIZ PHF20L1 IL4R

3.85e-04150253M2526
CoexpressionNAKAYA_PBMC_FLUMIST_AGE_18_50YO_3DY_DN

ARIH1 PHF20L1 ADAM8 JAG1 SORL1

4.00e-04680255M41089
CoexpressionCUI_DEVELOPING_HEART_C7_MAST_CELL

RNF130 NFKBIZ ADAM8

4.32e-04156253M39304
CoexpressionLI_CISPLATIN_RESISTANCE_DN

CFH JAG1

4.53e-0433252M10150
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP

RNF130 TBC1D8B ADAMTS2

4.65e-04160253M1346
CoexpressionGSE37301_CD4_TCELL_VS_RAG2_KO_NK_CELL_UP

ADAM8 JAG1 ADAMTSL2

4.91e-04163253M8905
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP

RNF130 TBC1D8B ADAMTS2

5.18e-04166253MM563
CoexpressionGSE6269_E_COLI_VS_STREP_PNEUMO_INF_PBMC_DN

PDIA5 ADAM8 JAG1

5.36e-04168253M5662
CoexpressionHALLMARK_ANGIOGENESIS

APP JAG1

5.39e-0436252M5944
CoexpressionGSE40274_CTRL_VS_LEF1_TRANSDUCED_ACTIVATED_CD4_TCELL_UP

CFH UNC5CL JAG1

5.74e-04172253M9090
CoexpressionGSE6269_E_COLI_VS_STAPH_AUREUS_INF_PBMC_DN

PDIA5 ADAM8 JAG1

6.04e-04175253M5660
CoexpressionHE_LIM_SUN_FETAL_LUNG_C4_ILCP_CELL

CFH APP JAG1

6.77e-04182253M45771
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP

NFKBIZ ADAMTS2 IL4R

6.99e-04184253M8544
CoexpressionESC_J1_UP_LATE.V1_UP

PDIA5 RNF130 APP

7.21e-04186253M2768
CoexpressionPATEL_SKIN_OF_BODY_ZOSTAVAX_AGE_70_93YO_VZV_CHALLENGE_3DY_DN

ARIH1 WDR72

7.35e-0442252M41055
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP

NFKBIZ ADAMTS2 IL4R

7.44e-04188253MM983
CoexpressionSHEPARD_CRASH_AND_BURN_MUTANT_DN

PHF20L1 CHD5 JAG1

7.78e-04191253M2148
CoexpressionAIZARANI_LIVER_C21_STELLATE_CELLS_1

CFH ADAMTS2 ADAMTSL2

8.14e-04194253M39122
CoexpressionGSE9509_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_20MIN_UP

CFH NFKBIZ ADAM8

8.27e-04195253M6899
CoexpressionGSE25087_TREG_VS_TCONV_ADULT_DN

PDIA5 ZBTB26 APP

8.27e-04195253M4652
CoexpressionGSE29618_PRE_VS_DAY7_FLU_VACCINE_BCELL_UP

MRPS18A JAG1 ADAMTSL2

8.39e-04196253M4972
CoexpressionGSE13485_CTRL_VS_DAY1_YF17D_VACCINE_PBMC_UP

MRPS18A ZBTB26 PHF20L1

8.39e-04196253M3280
CoexpressionGSE13411_NAIVE_BCELL_VS_PLASMA_CELL_UP

CHD3 APP IL4R

8.39e-04196253M3243
CoexpressionGSE13411_NAIVE_VS_IGM_MEMORY_BCELL_UP

PHF20L1 IL4R SORL1

8.39e-04196253M3239
CoexpressionGSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP

ARIH1 IL4R SORL1

8.51e-04197253M4434
CoexpressionGSE1460_DP_THYMOCYTE_VS_NAIVE_CD4_TCELL_ADULT_BLOOD_DN

RNF130 IL4R SORL1

8.51e-04197253M3465
CoexpressionGSE29618_BCELL_VS_PDC_DAY7_FLU_VACCINE_DN

RNF130 APP JAG1

8.64e-04198253M4959
CoexpressionGSE20727_CTRL_VS_H2O2_TREATED_DC_UP

RNF130 IL4R SORL1

8.64e-04198253M9245
CoexpressionGSE40666_UNTREATED_VS_IFNA_STIM_STAT1_KO_CD8_TCELL_90MIN_DN

CHD3 APP IL4R

8.64e-04198253M9234
CoexpressionGSE33292_DN3_THYMOCYTE_VS_TCF1_KO_TCELL_LYMPHOMA_UP

ADAM8 IL4R SORL1

8.77e-04199253M9424
CoexpressionGSE39556_UNTREATED_VS_3H_POLYIC_INJ_MOUSE_CD8A_DC_UP

ADAM8 IL4R JAG1

8.77e-04199253M9414
CoexpressionGSE41176_UNSTIM_VS_ANTI_IGM_STIM_BCELL_1H_DN

RNF130 EDC4 SORL1

8.77e-04199253M9913
CoexpressionGSE40225_WT_VS_RIP_B7X_DIABETIC_MOUSE_PANCREATIC_CD8_TCELL_UP

RNF130 IL4R SORL1

8.77e-04199253M9238
CoexpressionGSE39110_DAY3_VS_DAY6_POST_IMMUNIZATION_CD8_TCELL_WITH_IL2_TREATMENT_DN

APP IL4R UNC5CL

8.77e-04199253M9283
CoexpressionGSE21670_STAT3_KO_VS_WT_CD4_TCELL_DN

NFKBIZ PHF20L1 IL4R

8.77e-04199253M7454
CoexpressionGSE11924_TH2_VS_TH17_CD4_TCELL_UP

TRPA1 ADAMTSL3 JAG1

8.77e-04199253M3164
CoexpressionGSE5455_HEALTHY_VS_TUMOR_BEARING_MOUSE_SPLEEN_MONOCYTE_DN

ADAM8 UNC5CL SORL1

8.77e-04199253M6576
CoexpressionGSE1460_INTRATHYMIC_T_PROGENITOR_VS_CD4_THYMOCYTE_UP

MRPS18A CFH RNF130

8.77e-04199253M3439
CoexpressionGSE1460_CD4_THYMOCYTE_VS_NAIVE_CD4_TCELL_ADULT_BLOOD_DN

RNF130 ADAM8 SORL1

8.77e-04199253M3476
CoexpressionGRAHAM_CML_QUIESCENT_VS_NORMAL_QUIESCENT_DN

APP SORL1

8.81e-0446252M11636
CoexpressionGSE33425_CD8_ALPHAALPHA_VS_ALPHABETA_CD161_HIGH_TCELL_UP

MRPS18A IL4R SORL1

8.89e-04200253M8547
CoexpressionGSE27859_CD11C_INT_F480_HI_MACROPHAGE_VS_CD11C_ING_F480_INT_DC_DN

ADAM8 IL4R SORL1

8.89e-04200253M8598
CoexpressionGSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP

CFH ZBTB26 PHF20L1

8.89e-04200253M6459
CoexpressionGSE360_CTRL_VS_L_DONOVANI_DC_DN

EDC4 ADAM8 IL4R

8.89e-04200253M5144
CoexpressionGSE17721_4H_VS_24H_POLYIC_BMDC_DN

RNF130 APP SORL1

8.89e-04200253M4099
CoexpressionGSE12392_WT_VS_IFNB_KO_CD8A_POS_SPLEEN_DC_DN

ADAM8 TBC1D8B JAG1

8.89e-04200253M7144
CoexpressionGSE13484_UNSTIM_VS_YF17D_VACCINE_STIM_PBMC_UP

RNF130 EDC4 SORL1

8.89e-04200253M3277
CoexpressionGSE9650_EFFECTOR_VS_MEMORY_CD8_TCELL_DN

NFKBIZ IL4R SORL1

8.89e-04200253M5837
CoexpressionGSE24142_EARLY_THYMIC_PROGENITOR_VS_DN3_THYMOCYTE_UP

APP IL4R SORL1

8.89e-04200253M4553
CoexpressionGSE27786_CD4_TCELL_VS_MONO_MAC_DN

ADAMTSL3 ADAMTSL2 SORL1

8.89e-04200253M4834
CoexpressionGSE38304_MYC_NEG_VS_POS_GC_BCELL_UP

RNF130 CHD3 IL4R

8.89e-04200253M9273
CoexpressionGSE40666_WT_VS_STAT1_KO_CD8_TCELL_UP

IL4R UNC5CL SORL1

8.89e-04200253M9205
CoexpressionGSE22886_NAIVE_BCELL_VS_NEUTROPHIL_DN

RNF130 ADAM8 SORL1

8.89e-04200253M4482
CoexpressionGSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP

ARIH1 IL4R SORL1

8.89e-04200253M4440
CoexpressionGSE27434_WT_VS_DNMT1_KO_TREG_DN

NFKBIZ ARIH1 IL4R

8.89e-04200253M9621
CoexpressionGSE1460_DP_VS_CD4_THYMOCYTE_DN

PDIA5 APP IL4R

8.89e-04200253M3454
CoexpressionGSE20366_EX_VIVO_VS_DEC205_CONVERSION_NAIVE_CD4_TCELL_UP

RNF130 ZBTB26 UNC5CL

8.89e-04200253M4327
CoexpressionTABULA_MURIS_SENIS_MARROW_MONOCYTE_AGEING

CFH APP

1.21e-0354252MM3806
CoexpressionLINDGREN_BLADDER_CANCER_CLUSTER_3_DN

ARIH1 JAG1 SORL1

1.26e-03226253M11238
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH CHD3 APP UNC5CL

1.79e-061592541baf0eaf9684668146a63192e77eec6c3c7a37f8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTSL3 ADAMTS2 ADAMTSL2

3.20e-06184254c5436a8e45f471b8d1301abbe9c7879204537f52
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

CFH ADAMTSL3 ADAMTS2 JAG1

3.71e-0619125478c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTSL3 ADAMTS2 ADAMTSL2

3.79e-06192254bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTSL3 ADAMTS2 ADAMTSL2

3.79e-061922545105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTSL3 ADAMTS2 ADAMTSL2

3.79e-061922540ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCellCV-Severe-6|Severe / Virus stimulation, Condition and Cluster

NFKBIZ CHD3 ARIH1 ADAM8

3.95e-06194254d33be6ed1de907aeea0c2dce09796556b8efdd4e
ToppCellcritical-Epithelial-Secretory|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CFH CHD3 PHF20L1 SORL1

4.11e-06196254dbf14f5851c2b779a8b35e820c4584ea9096e49d
ToppCellRA-02._Fibroblast_II|World / Chamber and Cluster_Paper

CFH NFKBIZ ADAMTS2 ADAMTSL2

4.11e-06196254e8cbda03837f1f26470a9d93aa7fdaa04e08e38a
ToppCellBL|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NFKBIZ PHF20L1 IL4R SORL1

4.20e-061972541acf0191fa0a25cd20bfd9ea7bf727a1555986a1
ToppCellCOVID-19_Severe-Neu_1|COVID-19_Severe / 5 Neutrophil clusters in COVID-19 patients

NFKBIZ ADAM8 IL4R SORL1

4.28e-06198254bbe639ea5a636c985e509fb0a133ae3b60afac5a
ToppCellNS-control-d_0-4-Epithelial-Secretory|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CFH CHD3 PHF20L1 SORL1

4.37e-0619925432bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCellcontrol-Epithelial-Secretory|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CFH CHD3 PHF20L1 SORL1

4.37e-061992543d01f90ffd271ca00129192787e4921bdca7e01e
ToppCellcontrol-Epithelial-Secretory|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CFH CHD3 PHF20L1 SORL1

4.37e-06199254262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCellCOVID-19_Severe-Neu_1|World / 5 Neutrophil clusters in COVID-19 patients

NFKBIZ ADAM8 IL4R SORL1

4.37e-06199254e4d8bf016fd95a440e30014a75587e097e90cfad
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Mesenchymal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

NFKBIZ TBC1D8B ADAMTS2 IL4R

4.46e-06200254fe22f7c97f4e37dfa7881d0f1d9245c1237d873b
ToppCellAdult-Immune-enucleated_erythrocyte-D175|Adult / Lineage, Cell type, age group and donor

SAXO1 EDC4 CHD5

8.23e-05152253530d5427d8617dcb223d807b73abee0ef89285f3
ToppCelldroplet-Lung-LUNG-1m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFKBIZ ADAM8 SORL1

9.23e-0515825330cceb73cf5e24b692da84d33342fd3b1ad5efe5
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFKBIZ ADAM8 SORL1

9.23e-0515825347793463640f98ee5f680a1ee5786b453355fd57
ToppCelldroplet-Lung-1m-Hematologic-myeloid-neutrophil-neutrophil|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NFKBIZ ADAM8 SORL1

9.41e-05159253be54b910ccb73e37eb81945bbad9a89d2bcec34b
ToppCelldroplet-Lung-1m-Hematologic-myeloid-neutrophil|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NFKBIZ ADAM8 SORL1

9.41e-05159253178678173b005cb8225472306657f0d8289b133b
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1|E16.5-samps / Age Group, Lineage, Cell class and subclass

CFH ADAMTS2 ADAMTSL2

1.01e-04163253f1ec2625b52664308968b01d8e0275e1e0751480
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-Klrb1a/b/c(-)_NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHD3 ADAM8 JAG1

1.05e-04165253eeb58d4db64ad37dc6b441eab22b05c24862e1a9
ToppCellnormal_Lung-Myeloid_cells-CD163+CD14+_DCs|Myeloid_cells / Location, Cell class and cell subclass

NFKBIZ ADAM8 SORL1

1.07e-0416625307b498eb341abec02a3ccaae320bdbb5cd6883c5
ToppCellfacs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARIH1 ADAMTSL3 ADAM8

1.09e-04167253a82e85caf79395baa48380786d9df32a86dfd1ce
ToppCellfacs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARIH1 ADAMTSL3 ADAM8

1.09e-04167253528493896aebe7d03d4b6ad2341b12927859e2e4
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Col23a1_Adamts2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDIA5 ADAM8 ADAMTS2

1.11e-041682533fe432267656aff81b6d92c18d1b6fc0cde73d6a
ToppCellfacs-Marrow-Granulocytes-24m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFKBIZ ADAM8 SORL1

1.11e-041682533611605114f6b668b44728d6563cd02389e106af
ToppCellfacs-Marrow-Granulocytes-24m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFKBIZ ADAM8 SORL1

1.13e-04169253f38b52972a6c492ce2fd520a26bb3fc8db23bf85
ToppCellfacs-Marrow-Granulocytes-24m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFKBIZ ADAM8 SORL1

1.13e-041692535320da1d61806b53e0bd96bbdfdb8fd69246681b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTS2 ADAMTSL2

1.13e-04169253a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCellfacs-BAT-Fat-24m-Myeloid-granulocyte|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFKBIZ ADAM8 SORL1

1.15e-0417025353916d85f0d6c7e5ef3d900d6ead946f75e32567
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APP ADAM8 SORL1

1.17e-04171253ab21f20ec041cbaacccbd7da4dccdb77ec8bc5c6
ToppCellfacs-Marrow-Granulocytes|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APP ADAM8 SORL1

1.17e-041712531701dedf0c18751db6c9fee3d93fff150ed0e17f
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APP ADAM8 SORL1

1.17e-0417125397ad2cfff568a9d006ab1d2e6e00946ee4e3beb3
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-5|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PDIA5 APP IL4R

1.17e-0417125323b3120706bb9c20b9214fe3760c6d7a84f1e749
ToppCelldroplet-Marrow-nan-3m-Hematologic-proerythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFKBIZ ADAM8 SORL1

1.19e-04172253cfcfa7eeff1805bedf10a3c07826459914c3e872
ToppCellfacs-Marrow-T_cells-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APP ADAM8 SORL1

1.21e-041732530f9784b30c81a4a4940e0623cec60d596e9985d2
ToppCellfacs-Marrow-T_cells-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APP ADAM8 SORL1

1.21e-0417325360f79e0698a7cf7516690fb20f1b82ee46547699
ToppCelldroplet-Lung-21m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RNF130 NFKBIZ ADAM8

1.23e-041742538a8e98e62c2859c004b44dbce6974c9639ebeac6
ToppCelldroplet-Lung-21m-Hematologic-myeloid-Basophil/Mast_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RNF130 NFKBIZ ADAM8

1.23e-0417425331f7127faabcb1092bb9827db625f57cf7d8240e
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Neuronal-GABAergic_neurons|GW10 / Sample Type, Dataset, Time_group, and Cell type.

CFH ZBTB26 SAXO1

1.25e-04175253d4ff1f197ad4086286e86817cbff24fa718293fc
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTSL3 ADAMTS2

1.25e-04175253795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APP ADAM8 SORL1

1.29e-04177253065bebd22031f143e90a407f952b444a3f8818c7
ToppCellfacs-Marrow-Granulocytes-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APP ADAM8 SORL1

1.29e-04177253eb304f20aab075bd17aa3aef819386c0e1a235bd
ToppCellDendritic_Cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

RNF130 ADAM8 ADAMTS2

1.31e-0417825361ce3ec64c4cffceac08412e20c26e9c90ab8197
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTS2 ADAMTSL2

1.31e-04178253d4ecb84e9b1f4ec49c519321156aa10f9bd34cce
ToppCellfacs-Pancreas-Endocrine-24m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAMTSL3 ADAMTS2

1.34e-041792536f51a4580c06fc55cc764052c9b26f7c55660282
ToppCellfacs-Pancreas-Endocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAMTSL3 ADAMTS2

1.34e-04179253a6ce1fa338d4905bd6afef00763ac83e916a0b37
ToppCellfacs-Pancreas-Endocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAMTSL3 ADAMTS2

1.34e-04179253f14440f6ce9b4fcdd4bcb2488b949f9a0e17bc23
ToppCellCOVID-19-Heart-Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

TRPA1 ADAMTSL3 JAG1

1.38e-0418125333cac65ed1ea5e7bd72250495df4f850b143d5aa
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RNF130 ADAMTSL3 WDR72

1.38e-04181253b7c85fbef3c06d5dc32a2a58f8d3dfabf1d79d9f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL3 ADAMTS2 ADAMTSL2

1.40e-0418225344764676ed3f51ba171ce63f669390392fa50a43
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL3 ADAMTS2 ADAMTSL2

1.40e-04182253d82f59a3f930a840dde27dc6ab024f227a26d446
ToppCellwk_20-22-Mesenchymal-Chondrocyte-intermediate_chondrocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CFH ADAMTSL3 TBC1D8B

1.43e-041832531464b5c4425e8776c4aeb4d2b560481d4bf13931
ToppCelldroplet-Lung-nan-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAMTS2 ADAMTSL2

1.43e-04183253ddc45fb591ba0ce3fa05c08051d58286a89ef835
ToppCelldroplet-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAMTS2 ADAMTSL2

1.43e-04183253a253ad65673fce6cb453e709cb235ce7cbfa18b7
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTSL3 ADAMTS2

1.45e-04184253e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D122|Adult / Lineage, Cell type, age group and donor

CFH ADAMTSL3 ADAMTSL2

1.45e-041842532b7e6f91e11c228f0521e099886867d9e998e78d
ToppCellCOVID-19-Fibroblasts-Pericytes|COVID-19 / group, cell type (main and fine annotations)

ADAMTSL3 JAG1 ADAMTSL2

1.47e-041852534905adaeeffd353e089578e5ea614437dbe794e6
ToppCellP15-Mesenchymal-mesenchymal_fibroblast|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CFH ADAMTS2 ADAMTSL2

1.47e-0418525346460e74cc613df9043f5404e7342aa13cc34873
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D231|Adult / Lineage, Cell type, age group and donor

CFH ADAMTSL3 ADAMTS2

1.47e-04185253fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCellMild-NK|World / Disease group and Cell class

RNF130 JAG1 WDR72

1.47e-041852530565b7c464e1a09e596f5a0b363d2dc9b55c3c50
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RNF130 ADAM8 IL4R

1.50e-04186253de55471dd5c842026b409cfebf67fe32f079a011
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

ADAMTSL3 ADAMTS2 JAG1

1.50e-04186253cb1fc4b9140666b43415e21c9b434dc9b144e9d0
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAMTSL3 ADAMTS2

1.52e-041872534e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAMTSL3 ADAMTS2

1.52e-04187253d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAMTSL3 ADAMTS2

1.52e-04187253827eae63fabf6892a82ce7779b5f395958d3d628
ToppCelldroplet-Bladder-Unstain-18m-Epithelial-bladder_mesenchymal_cell_(Scara5+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAMTSL3 ADAMTS2

1.52e-041872537beba2a5d5978f2ae7d8bde10815705cf2572211
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

CFH ADAMTSL3 ADAMTS2

1.52e-04187253bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PDIA5 TRPA1 JAG1

1.52e-041872537170694a1b86fe8d84d96c880ffe57af09bdc026
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

ADAMTSL3 ADAMTS2 ADAMTSL2

1.52e-0418725392d468dde81125d51daf7abd4703741abe1ab91c
ToppCellP15-Mesenchymal|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CFH ADAMTS2 ADAMTSL2

1.54e-04188253f1ba0b661621a65c91432e62ba73531bdf18e7c1
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFH ADAMTS2 ADAMTSL2

1.57e-0418925340cbd679dc0548bf5207e1b033c0597886ad6fe1
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RNF130 ADAMTSL3 WDR72

1.57e-04189253c9565e962a13a7713056ec3dbb1b67d24f9889c7
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTS2 ADAMTSL2

1.57e-0418925371397e993a77d70b2eeede240bdfc7660b558987
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTS2 ADAMTSL2

1.57e-041892534eea4759520c312bd17a681034d8074e47093d2b
ToppCellcellseq-Immune-Hematopoietic-Granulocytic-Neutrophil|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NFKBIZ ADAM8 SORL1

1.57e-04189253fedab592be1d6520325b8c1b659b0a4dc3f4fe4d
ToppCell10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like|lymph-node_spleen / Manually curated celltypes from each tissue

CFH NFKBIZ JAG1

1.59e-041902530c7eb8f4f2926af01bf44d5c9f239be7b81c67fe
ToppCelldroplet-Kidney-nan-3m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAMTSL3 ADAMTS2

1.59e-04190253f61e21d53f2f7804ac6e40ab6c7f69838aa94d6a
ToppCelldroplet-Kidney-nan-3m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAMTSL3 ADAMTS2

1.59e-041902532abeb013bb83c578e67dcb985ba44ca63134950b
ToppCellControl-Fibroblasts|Control / group, cell type (main and fine annotations)

CFH ADAMTSL3 ADAMTS2

1.59e-041902533a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCelldroplet-Heart-nan-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAMTS2 ADAMTSL2

1.59e-0419025396a92212ea3fb35fa3d0da495e504edc61c71c23
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTS2 ADAMTSL2

1.62e-0419125339092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCellfacs-Aorta-Heart-18m|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAMTSL3 ADAMTS2

1.62e-041912536242f83acaf1714e9c1771a832cb67674b19e96d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTS2 ADAMTSL2

1.62e-04191253a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCellRV-01._Fibroblast_I|World / Chamber and Cluster_Paper

CFH NFKBIZ ADAMTSL3

1.62e-0419125370c067c54084bfb02c29bab085f4defd477194fb
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Monocytic|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NFKBIZ ADAM8 SORL1

1.62e-041912534d7f6216958fb202426b7a102e74682105ce7fca
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Monocytic-Classical_Monocyte|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NFKBIZ ADAM8 SORL1

1.62e-04191253e979f6768065b8b3e522d66999ca794d844eccb4
ToppCell(5)_Epi_basal|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

CFH APP WDR72

1.62e-041912536bda3d5a8a391d41bb4d65872492e6c094bcc4d4
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFH ADAMTS2 ADAMTSL2

1.62e-04191253094c9d3270fc1e487ccf10fb4936af5f081f6009
ToppCell(1)_Control_(PBS)|World / Stress and Cell class

CFH NFKBIZ APP

1.62e-04191253b346e13259cb2d506b923ad44b894c21a3eee4c3
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTS2 ADAMTSL2

1.62e-041912538f6d592edc32fdb901af30501d4360512334e8c2
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFH ADAMTS2 ADAMTSL2

1.62e-04191253997abf0cc5873bed0372c4a333ed307fa72774d2
ToppCellfacs-Lung-24m-Mesenchymal|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFH ADAMTS2 ADAMTSL2

1.62e-04191253ba02cbdfda6a94374a6472eb88499059979af472
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CFH ADAMTSL3 ADAMTS2

1.62e-041912536688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTS2 ADAMTSL2

1.62e-04191253ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CFH ADAMTSL3 ADAMTS2

1.64e-0419225399ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

NFKBIZ ADAMTS2 IL4R

1.64e-041922538b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCellfacs-Aorta-Heart-18m-Mesenchymal|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAMTSL3 ADAMTS2

1.64e-041922536d4fe7ea278efa4b9d43f8a3c282bc0e0e9abaea
Drugolivetol

RNF130 JAG1

5.18e-0510252CID000010377
DrugHexylcaine hydrochloride [532-76-3]; Up 200; 13.4uM; MCF7; HT_HG-U133A

CHD3 APP IL4R USP19

5.73e-051952546244_UP
DrugMethiazole; Down 200; 15uM; PC3; HT_HG-U133A

CHD3 TBC1D8B IL4R USP19

5.96e-051972544532_DN
DrugNicergoline; Up 200; 8.2uM; MCF7; HT_HG-U133A

CHD3 ADAM8 IL4R JAG1

6.08e-051982546251_UP
DrugMeticrane [1084-65-7]; Up 200; 14.6uM; MCF7; HT_HG-U133A

TRPA1 APP ADAM8 IL4R

6.08e-051982545984_UP
DrugN-phenylanthranilic acid; Up 200; 10uM; MCF7; HG-U133A

TRPA1 TBC1D8B ADAMTS2 IL4R

6.08e-05198254317_UP
DrugSaquinavir mesylate [149845-06-7]; Up 200; 5.2uM; MCF7; HT_HG-U133A

CHD3 APP IL4R JAG1

6.32e-052002546246_UP
DrugAC1L1B35

APP ADAMTS2 SORL1

7.20e-0574253CID000001263
DrugMS-551

ARIH1 ADAM8

8.96e-0513252CID000004486
DrugNSC523374

CFH ADAMTS2

1.38e-0416252CID000101638
DrugSerotonin

TRPA1 APP SORL1

2.80e-04117253ctd:D012701
DrugRuthenium Red

TRPA1 APP

2.89e-0423252ctd:D012430
DrugLY127935

ADAM8 JAG1

4.00e-0427252CID000003889
Drugtucaresol

RNF130 IL4R

4.30e-0428252CID000055223
DrugAC1L1JK6

APP ADAMTS2

5.28e-0431252CID000005077
DrugG-P-G

RNF130 ADAMTS2

5.63e-0432252CID000485267
DrugMebendazole [31431-39-7]; Up 200; 13.6uM; HL60; HT_HG-U133A

ADAM8 IL4R JAG1

6.74e-041582532338_UP
Drugmetrifonate

APP ADAMTS2

7.53e-0437252CID000005853
DrugDB08184

RNF130 CHD3 CHD5

7.92e-04167253CID009547945
DrugTrenbolone Acetate

CFH APP

7.94e-0438252ctd:D014204
Drugisopentenyladenine

ADAM8 JAG1

8.80e-0440252CID000092180
DrugDipivefrin hydrochloride [64019-93-8]; Up 200; 10.4uM; HL60; HG-U133A

EDC4 ADAM8 IL4R

9.83e-041802531752_UP
Drugvicriviroc

RNF130 IL4R

1.02e-0343252CID003009355
Drug17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A

CHD3 JAG1 SORL1

1.03e-031832536985_UP
DrugN-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester

APP JAG1

1.06e-0344252ctd:C419410
DrugSpiperone [749-02-0]; Down 200; 10.2uM; PC3; HT_HG-U133A

APP IL4R SORL1

1.08e-031862535777_DN
Drugfosmidomycin

CFH JAG1

1.11e-0345252CID000000572
DrugTN-2

ARIH1 JAG1

1.11e-0345252CID006852143
DrugSyrosingopine [84-36-6]; Up 200; 6uM; HL60; HG-U133A

APP ADAM8 JAG1

1.17e-031912531761_UP
DrugMefloquine hydrochloride [51773-92-3]; Down 200; 9.6uM; PC3; HT_HG-U133A

CHD3 EDC4 APP

1.17e-031912532048_DN
Drugradicicol; Up 200; 0.1uM; HL60; HG-U133A

CHD3 APP JAG1

1.20e-03193253544_UP
DrugLY294002; Up 200; 10uM; SKMEL5; HG-U133A

CHD3 APP TBC1D8B

1.20e-03193253501_UP
DrugEucatropine hydrochloride [536-93-6]; Down 200; 12.2uM; MCF7; HT_HG-U133A

ARIH1 APP IL4R

1.20e-031932533841_DN
DiseaseMental deterioration

APP SORL1

2.47e-059252C0234985
DiseaseMild cognitive disorder

APP SORL1

2.47e-059252C1270972
Diseasesynaptotagmin-11 measurement

CFH PDIA5

2.47e-059252EFO_0802108
DiseaseFacies

JAG1 ADAMTSL2

3.09e-0510252C0282631
Diseasevascular endothelial growth factor A measurement

MRPS18A CFH

4.52e-0512252EFO_0010804
DiseaseImpaired cognition

APP SORL1

6.23e-0514252C0338656
DiseaseAlzheimer disease, family history of Alzheimer’s disease

APP UNC5CL SORL1

1.38e-04119253EFO_0009268, MONDO_0004975
Diseasecorpus callosum mid-anterior volume measurement

JAG1 WDR72

2.39e-0427252EFO_0010297
Diseasecolorectal cancer, overall survival

UNC5CL SORL1

2.76e-0429252EFO_0000638, MONDO_0005575
Diseaserheumatic heart disease

CFH SORL1

3.58e-0433252EFO_1001161
Diseaseosteoarthritis (is_marker_for)

IL4R JAG1

4.03e-0435252DOID:8398 (is_marker_for)
Diseaseasthma (implicated_via_orthology)

TRPA1 IL4R

4.03e-0435252DOID:2841 (implicated_via_orthology)
Diseasemacula measurement

CHD3 SORL1 WDR72

5.36e-04189253EFO_0008375
Diseasecomplement factor H-related protein 5 measurement

CFH SORL1

5.81e-0442252EFO_0008098

Protein segments in the cluster

PeptideGeneStartEntry
KAPEGKWSCPHCEKE

CHD5

376

Q8TDI0
NWCKRGRKQCKTHPH

APP

96

P05067
AKCLGEKWSHPPSCI

CFH

971

P08603
CHAGWAPPHCAKLLT

ADAM8

631

P78325
PGKHCFKGHCIWLTP

ADAMTS2

541

O95450
CLHEWKPHDGRPLSC

EDC4

336

Q6P2E9
PCKHVFHKSCVDPWL

RNF130

281

Q86XS8
RLLKWCPAPDCHHVV

ARIH1

271

Q9Y4X5
CWGRTPLHVCAEKGH

NFKBIZ

511

Q9BYH8
SDILTPRHCKHCPWA

C9orf131

1026

Q5VYM1
IHPCGDKNCPAHWLA

ADAMTSL2

786

Q86TH1
SRGQEPAKCPHWKNC

IL4R

291

P24394
DRAPEGKWSCPHCEK

CHD3

411

Q12873
HAPWCGHCKKMKPEF

PDIA5

301

Q14554
WCGPRPCLLHKGHSE

JAG1

896

P78504
KGQVKSQHPLSWCCP

PHF20L1

141

A8MW92
PKTCIPNWKRCDGHQ

SORL1

1481

Q92673
HLPINTKSCKPHWSG

SAXO1

381

Q8IYX7
PSGQCPICRWNLKHK

MRPS18A

66

Q9NVS2
CQKTHWPDHKGLCRP

USP19

821

O94966
PCKSNKWGCFPIHQA

TRPA1

191

O75762
WCLGCPVLKHHDPSL

TBC1D8B

816

Q0IIM8
CQLVPHLHIWHGKCP

UNC5CL

326

Q8IV45
EPRHHSWIAKVCPCK

WDR72

1086

Q3MJ13
DKGLQWHHQCPKCTR

ZBTB26

266

Q9HCK0
KKKPISWRHCLGPSC

ADAMTSL3

1641

P82987