Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncholesterol-protein transferase activity

SHH IHH

2.30e-063182GO:0140853
GeneOntologyMolecularFunctionmetalloendopeptidase activity

MMP17 MMP21 THOP1 ASTL

3.56e-06120184GO:0004222
GeneOntologyMolecularFunctiondATP binding

ST13P5 ST13

7.66e-065182GO:0032564
GeneOntologyMolecularFunctionadenyl deoxyribonucleotide binding

ST13P5 ST13

1.15e-056182GO:0032558
GeneOntologyMolecularFunctionpeptidase activity

SHH MMP17 MMP21 THOP1 IHH ASTL

1.60e-05654186GO:0008233
GeneOntologyMolecularFunctionpurine deoxyribonucleotide binding

ST13P5 ST13

1.61e-057182GO:0032554
GeneOntologyMolecularFunctionpatched binding

SHH IHH

2.14e-058182GO:0005113
GeneOntologyMolecularFunctionmetallopeptidase activity

MMP17 MMP21 THOP1 ASTL

2.68e-05200184GO:0008237
GeneOntologyMolecularFunctiondeoxyribonucleotide binding

ST13P5 ST13

2.75e-059182GO:0032552
GeneOntologyMolecularFunctionendopeptidase activity

SHH MMP17 MMP21 THOP1 ASTL

3.08e-05430185GO:0004175
GeneOntologyMolecularFunctionzinc ion binding

SHH MMP17 MMP21 L3MBTL1 ASTL

9.22e-04891185GO:0008270
GeneOntologyMolecularFunctionE-box binding

ATOH7 ATOH1

1.36e-0361182GO:0070888
GeneOntologyMolecularFunctionHsp70 protein binding

ST13P5 ST13

1.45e-0363182GO:0030544
GeneOntologyMolecularFunctiontransition metal ion binding

SHH MMP17 MMP21 L3MBTL1 ASTL

3.31e-031189185GO:0046914
GeneOntologyMolecularFunctionprotein dimerization activity

ST13P5 ATOH7 ST13P4 ST13 ATOH1

3.51e-031205185GO:0046983
GeneOntologyMolecularFunctionunfolded protein binding

ST13P5 ST13

5.66e-03126182GO:0051082
GeneOntologyMolecularFunctionprotein-folding chaperone binding

ST13P5 ST13

9.08e-03161182GO:0051087
GeneOntologyMolecularFunctionheat shock protein binding

ST13P5 ST13

9.30e-03163182GO:0031072
GeneOntologyBiologicalProcessneuron fate commitment

SHH ATOH7 ATOH1 IHH

8.07e-0791174GO:0048663
GeneOntologyBiologicalProcessprotein splicing

SHH IHH

1.92e-063172GO:0030908
GeneOntologyBiologicalProcessintein-mediated protein splicing

SHH IHH

1.92e-063172GO:0016539
GeneOntologyBiologicalProcessnegative regulation of protein refolding

ST13P5 ST13

6.38e-065172GO:0061084
GeneOntologyBiologicalProcessregulation of protein refolding

ST13P5 ST13

9.57e-066172GO:0061083
GeneOntologyBiologicalProcessnegative regulation of protein folding

ST13P5 ST13

1.34e-057172GO:1903333
GeneOntologyBiologicalProcessdetermination of heart left/right asymmetry

SHH MMP21 IHH

3.54e-0579173GO:0061371
GeneOntologyBiologicalProcessnegative regulation of T cell differentiation in thymus

SHH IHH

4.96e-0513172GO:0033085
GeneOntologyBiologicalProcesspositive regulation of T cell differentiation in thymus

SHH IHH

4.96e-0513172GO:0033089
GeneOntologyBiologicalProcessregulation of protein folding

ST13P5 ST13

5.78e-0514172GO:1903332
GeneOntologyBiologicalProcessself proteolysis

SHH IHH

6.67e-0515172GO:0097264
GeneOntologyBiologicalProcessregulation of immature T cell proliferation in thymus

SHH IHH

8.63e-0517172GO:0033084
GeneOntologyBiologicalProcessregulation of immature T cell proliferation

SHH IHH

9.71e-0518172GO:0033083
GeneOntologyBiologicalProcessimmature T cell proliferation in thymus

SHH IHH

1.08e-0419172GO:0033080
GeneOntologyBiologicalProcessprotein maturation

SHH ST13P5 ST13 IHH ASTL

1.10e-04619175GO:0051604
GeneOntologyBiologicalProcessimmature T cell proliferation

SHH IHH

1.20e-0420172GO:0033079
GeneOntologyBiologicalProcesschondrocyte differentiation involved in endochondral bone morphogenesis

COL27A1 IHH

1.20e-0420172GO:0003413
GeneOntologyBiologicalProcesscell fate specification

SHH ATOH1 IHH

1.32e-04123173GO:0001708
GeneOntologyBiologicalProcessembryonic digestive tract morphogenesis

SHH IHH

1.33e-0421172GO:0048557
GeneOntologyBiologicalProcesscell fate commitment

SHH ATOH7 ATOH1 IHH

1.42e-04338174GO:0045165
GeneOntologyBiologicalProcessextracellular matrix organization

MMP17 MMP21 COL27A1 IHH

2.17e-04377174GO:0030198
GeneOntologyBiologicalProcessextracellular structure organization

MMP17 MMP21 COL27A1 IHH

2.19e-04378174GO:0043062
GeneOntologyBiologicalProcessexternal encapsulating structure organization

MMP17 MMP21 COL27A1 IHH

2.21e-04379174GO:0045229
GeneOntologyBiologicalProcesscollagen metabolic process

MMP17 MMP21 IHH

2.29e-04148173GO:0032963
GeneOntologyBiologicalProcesssmooth muscle tissue development

SHH IHH

2.56e-0429172GO:0048745
GeneOntologyBiologicalProcessdetermination of left/right symmetry

SHH MMP21 IHH

2.57e-04154173GO:0007368
GeneOntologyBiologicalProcessprotein refolding

ST13P5 ST13

2.74e-0430172GO:0042026
GeneOntologyBiologicalProcessprotein autoprocessing

SHH IHH

2.74e-0430172GO:0016540
GeneOntologyBiologicalProcessnegative regulation of alpha-beta T cell differentiation

SHH IHH

2.93e-0431172GO:0046639
GeneOntologyBiologicalProcessleft/right pattern formation

SHH MMP21 IHH

2.98e-04162173GO:0060972
GeneOntologyBiologicalProcessdetermination of bilateral symmetry

SHH MMP21 IHH

3.15e-04165173GO:0009855
GeneOntologyBiologicalProcessspecification of symmetry

SHH MMP21 IHH

3.15e-04165173GO:0009799
GeneOntologyBiologicalProcessembryonic digestive tract development

SHH IHH

3.74e-0435172GO:0048566
GeneOntologyBiologicalProcesschaperone cofactor-dependent protein refolding

ST13P5 ST13

3.74e-0435172GO:0051085
GeneOntologyBiologicalProcesspositive regulation of mesenchymal cell proliferation

SHH IHH

3.96e-0436172GO:0002053
GeneOntologyBiologicalProcessregulation of T cell differentiation in thymus

SHH IHH

4.19e-0437172GO:0033081
GeneOntologyBiologicalProcess'de novo' post-translational protein folding

ST13P5 ST13

5.14e-0441172GO:0051084
GeneOntologyBiologicalProcessneuron fate specification

SHH ATOH1

5.40e-0442172GO:0048665
GeneOntologyBiologicalProcessregulation of mesenchymal cell proliferation

SHH IHH

6.20e-0445172GO:0010464
GeneOntologyBiologicalProcesspositive regulation of smoothened signaling pathway

SHH IHH

6.20e-0445172GO:0045880
GeneOntologyBiologicalProcess'de novo' protein folding

ST13P5 ST13

6.48e-0446172GO:0006458
GeneOntologyBiologicalProcesscartilage development involved in endochondral bone morphogenesis

COL27A1 IHH

6.76e-0447172GO:0060351
GeneOntologyBiologicalProcessbranching involved in blood vessel morphogenesis

SHH IHH

6.76e-0447172GO:0001569
GeneOntologyBiologicalProcessepithelial cell morphogenesis

COL27A1 IHH

7.35e-0449172GO:0003382
GeneOntologyBiologicalProcessnegative regulation of alpha-beta T cell activation

SHH IHH

8.28e-0452172GO:0046636
GeneOntologyBiologicalProcesscollagen catabolic process

MMP17 MMP21

8.60e-0453172GO:0030574
GeneOntologyBiologicalProcessnegative regulation of lipid transport

SHH PLA2R1

9.59e-0456172GO:0032369
GeneOntologyBiologicalProcessembryonic organ development

SHH COL27A1 ATOH1 IHH

9.72e-04561174GO:0048568
GeneOntologyBiologicalProcessnegative regulation of T cell differentiation

SHH IHH

1.03e-0358172GO:0045581
GeneOntologyBiologicalProcessmesenchymal cell proliferation

SHH IHH

1.06e-0359172GO:0010463
GeneOntologyBiologicalProcessdigestive tract morphogenesis

SHH IHH

1.06e-0359172GO:0048546
GeneOntologyBiologicalProcesspositive regulation of alpha-beta T cell differentiation

SHH IHH

1.25e-0364172GO:0046638
GeneOntologyBiologicalProcessnegative regulation of lymphocyte differentiation

SHH IHH

1.49e-0370172GO:0045620
GeneOntologyBiologicalProcessprotein processing

SHH IHH ASTL

1.54e-03285173GO:0016485
GeneOntologyBiologicalProcessaxon guidance

SHH ATOH7 ATOH1

1.54e-03285173GO:0007411
GeneOntologyBiologicalProcessneuron projection guidance

SHH ATOH7 ATOH1

1.55e-03286173GO:0097485
GeneOntologyBiologicalProcessheart looping

SHH IHH

1.62e-0373172GO:0001947
GeneOntologyBiologicalProcessembryonic digit morphogenesis

SHH IHH

1.67e-0374172GO:0042733
GeneOntologyBiologicalProcessnegative regulation of lipid localization

SHH PLA2R1

1.85e-0378172GO:1905953
GeneOntologyBiologicalProcessendochondral bone morphogenesis

COL27A1 IHH

1.90e-0379172GO:0060350
GeneOntologyBiologicalProcessembryonic heart tube morphogenesis

SHH IHH

1.95e-0380172GO:0003143
GeneOntologyBiologicalProcesschaperone-mediated protein folding

ST13P5 ST13

1.95e-0380172GO:0061077
GeneOntologyBiologicalProcesscoronary vasculature development

SHH MMP21

2.09e-0383172GO:0060976
GeneOntologyBiologicalProcesscell morphogenesis

SHH ATOH7 COL27A1 ATOH1 IHH

2.22e-031194175GO:0000902
GeneOntologyBiologicalProcesspositive regulation of alpha-beta T cell activation

SHH IHH

2.40e-0389172GO:0046635
GeneOntologyCellularComponentextracellular matrix

SHH MMP17 MMP21 COL27A1 IHH

1.83e-04656185GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

SHH MMP17 MMP21 COL27A1 IHH

1.85e-04658185GO:0030312
MousePhenoannular pancreas

SHH IHH

2.79e-063142MP:0006261
MousePhenoabnormal chondrocyte physiology

SHH COL27A1 IHH

8.97e-0642143MP:0009780
MousePhenoabnormal cartilage physiology

SHH COL27A1 IHH

9.64e-0643143MP:0031306
MousePhenoabnormal digestive organ placement

SHH MMP21 IHH

2.27e-0557143MP:0003283
MousePhenoabnormal chondrocyte morphology

SHH COL27A1 IHH

7.01e-0583143MP:0000166
MousePhenodecreased chondrocyte proliferation

SHH IHH

1.11e-0416142MP:0014101
MousePhenochondrodystrophy

COL27A1 IHH

1.41e-0418142MP:0002657
MousePhenobrachyphalangia

SHH IHH

1.58e-0419142MP:0002543
MousePhenoshort limbs

SHH COL27A1 IHH

1.66e-04111143MP:0000547
MousePhenoabnormal chondrocyte proliferation

SHH IHH

1.75e-0420142MP:0014099
MousePhenoabnormal enteric neuron morphology

SHH IHH

2.13e-0422142MP:0001046
MousePhenoabnormal chondrocyte differentiation

SHH IHH

2.33e-0423142MP:0014105
MousePhenoabnormal enteric nervous system morphology

SHH IHH

4.26e-0431142MP:0001044
MousePhenorespiratory failure

COL27A1 ATOH1 IHH

5.34e-04165143MP:0001953
MousePhenodecreased respiration

COL27A1 ATOH1 IHH

5.83e-04170143MP:0014274
MousePhenoabnormal cartilage development

SHH COL27A1 IHH

6.03e-04172143MP:0000164
MousePhenoabnormal optic vesicle formation

SHH ATOH7

9.81e-0447142MP:0003425
MousePhenoabnormal fibula morphology

SHH IHH

1.15e-0351142MP:0002187
MousePhenoabnormal cerebellum external granule cell layer morphology

SHH ATOH1

1.20e-0352142MP:0000872
MousePhenodecreased fetal size

SHH COL27A1 IHH

1.38e-03229143MP:0004200
MousePhenoabnormal jaw morphology

SHH MMP21 COL27A1 IHH

1.51e-03530144MP:0000454
MousePhenoabnormal fetal size

SHH COL27A1 IHH

1.53e-03237143MP:0004198
MousePhenoneonatal lethality, complete penetrance

SHH COL27A1 ATOH1 IHH

1.55e-03534144MP:0011087
MousePhenoabnormal duodenum morphology

SHH IHH

1.81e-0364142MP:0003271
MousePhenoabnormal long bone epiphyseal plate proliferative zone

COL27A1 IHH

2.04e-0368142MP:0003662
MousePhenoabnormal viscerocranium morphology

SHH MMP21 COL27A1 IHH

2.28e-03593144MP:0005274
MousePhenoabnormal phalanx morphology

SHH IHH

2.54e-0376142MP:0005306
MousePhenoabnormal skeleton physiology

SHH CLK1 COL27A1 IHH

2.88e-03632144MP:0001533
MousePhenoabnormal inner ear vestibule morphology

SHH ATOH1

2.88e-0381142MP:0000034
MousePhenodomed cranium

COL27A1 IHH

3.17e-0385142MP:0000440
MousePhenoabnormal fetal growth/weight/body size

SHH COL27A1 IHH

3.34e-03312143MP:0004197
MousePhenoabnormal autonomic nervous system morphology

SHH IHH

3.47e-0389142MP:0002751
DomainINTEIN_N_TER

SHH IHH

8.77e-072182PS50817
DomainIntein_N

SHH IHH

8.77e-072182IPR006141
Domain-

MMP17 MMP21 THOP1 ASTL

9.59e-07811843.40.390.10
DomainMetalloPept_cat_dom

MMP17 MMP21 THOP1 ASTL

9.59e-0781184IPR024079
DomainZINC_PROTEASE

MMP17 MMP21 THOP1 ASTL

2.06e-0698184PS00142
DomainHint_dom_N

SHH IHH

2.63e-063182IPR003587
DomainHedgehog_sig/DD-Pept_Zn-bd_dom

SHH IHH

2.63e-063182IPR009045
DomainHint_dom_C

SHH IHH

2.63e-063182IPR003586
DomainHedgehog_signalling_dom

SHH IHH

2.63e-063182IPR000320
DomainHintN

SHH IHH

2.63e-063182SM00306
DomainHintC

SHH IHH

2.63e-063182SM00305
DomainHH_signal

SHH IHH

2.63e-063182PF01085
DomainHedgehog

SHH IHH

2.63e-063182IPR001657
Domain-

SHH IHH

2.63e-0631823.30.1380.10
DomainHint

SHH IHH

2.63e-063182PF01079
DomainHint_dom

SHH IHH

2.63e-063182IPR001767
DomainZnMc

MMP17 MMP21 ASTL

2.70e-0629183SM00235
DomainPeptidase_Metallo

MMP17 MMP21 ASTL

2.70e-0629183IPR006026
DomainHedgehog/Intein_dom

SHH IHH

5.26e-064182IPR028992
Domain-

SHH IHH

5.26e-0641822.170.16.10
DomainSTI1_HS-bd

ST13P5 ST13

3.93e-0510182IPR006636
DomainSTI1

ST13P5 ST13

3.93e-0510182SM00727
DomainTPR_1

ST13P5 ST13P4 ST13

8.38e-0590183PF00515
DomainTPR_1

ST13P5 ST13P4 ST13

8.38e-0590183IPR001440
DomainPept_M10A_stromelysin-type

MMP17 MMP21

1.33e-0418182IPR016293
DomainPeptidoglycan-bd-like

MMP17 MMP21

1.65e-0420182IPR002477
DomainPG_binding_1

MMP17 MMP21

1.65e-0420182PF01471
DomainHEMOPEXIN

MMP17 MMP21

2.19e-0423182PS00024
Domain-

MMP17 MMP21

2.19e-04231822.110.10.10
DomainHemopexin-like_dom

MMP17 MMP21

2.19e-0423182IPR000585
DomainHEMOPEXIN_2

MMP17 MMP21

2.19e-0423182PS51642
DomainHemopexin-like_repeat

MMP17 MMP21

2.19e-0423182IPR018487
DomainHemopexin

MMP17 MMP21

2.19e-0423182PF00045
DomainHX

MMP17 MMP21

2.19e-0423182SM00120
DomainPept_M10A

MMP17 MMP21

2.19e-0423182IPR021190
DomainM10A_MMP

MMP17 MMP21

2.19e-0423182IPR033739
DomainPeptidase_M10

MMP17 MMP21

2.39e-0424182PF00413
DomainTPR

ST13P5 ST13P4 ST13

2.43e-04129183SM00028
DomainTPR-contain_dom

ST13P5 ST13P4 ST13

3.79e-04150183IPR013026
DomainTPR

ST13P5 ST13P4 ST13

5.01e-04165183PS50005
DomainTPR_REGION

ST13P5 ST13P4 ST13

5.01e-04165183PS50293
DomainCYSTEINE_SWITCH

MMP17 MMP21

7.04e-0441182PS00546
DomainPept_M10_metallopeptidase

MMP17 MMP21

7.74e-0443182IPR001818
DomainTPR-like_helical_dom

ST13P5 ST13P4 ST13

1.36e-03233183IPR011990
Domain-

ATOH7 ATOH1

4.86e-031091824.10.280.10
DomainHLH

ATOH7 ATOH1

5.03e-03111182PF00010
DomainHLH

ATOH7 ATOH1

5.48e-03116182SM00353
DomainBHLH

ATOH7 ATOH1

5.58e-03117182PS50888
DomainbHLH_dom

ATOH7 ATOH1

5.67e-03118182IPR011598
PathwayREACTOME_FORMATION_OF_LATERAL_PLATE_MESODERM

SHH IHH

1.21e-055162M46432
PathwayKEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY_HH_LIGAND_SECRETION

SHH IHH

1.81e-056162M47892
PathwayREACTOME_LIGAND_RECEPTOR_INTERACTIONS

SHH IHH

2.53e-057162MM15224
PathwayREACTOME_RELEASE_OF_HH_NP_FROM_THE_SECRETING_CELL

SHH IHH

2.53e-057162MM15187
PathwayREACTOME_RELEASE_OF_HH_NP_FROM_THE_SECRETING_CELL

SHH IHH

3.37e-058162M27444
PathwayREACTOME_LIGAND_RECEPTOR_INTERACTIONS

SHH IHH

3.37e-058162M27496
PathwayKEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY_PTCH_CORECEPTOR

SHH IHH

4.33e-059162M47893
PathwayKEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY

SHH IHH

1.09e-0414162M47414
PathwayREACTOME_ACTIVATION_OF_SMO

SHH IHH

1.09e-0414162MM15228
PathwayWP_HEDGEHOG_SIGNALING_WP47

SHH IHH

1.44e-0416162M39675
PathwayREACTOME_ACTIVATION_OF_SMO

SHH IHH

1.83e-0418162M27500
PathwayWP_HEDGEHOG_SIGNALING_PATHWAY

SHH IHH

2.75e-0422162MM15924
PathwayPID_HEDGEHOG_2PATHWAY

SHH IHH

2.75e-0422162M211
PathwayWP_MATRIX_METALLOPROTEINASES

MMP17 MMP21

4.82e-0429162MM15981
PathwayWP_MATRIX_METALLOPROTEINASES

MMP17 MMP21

5.16e-0430162M39652
PathwayWP_HEDGEHOG_SIGNALING_WP4249

SHH IHH

1.06e-0343162M39706
PathwayWP_CHRONIC_HYPERGLYCEMIA_IMPAIRMENT_OF_NEURON_FUNCTION

MMP17 MMP21

1.21e-0346162M46450
PathwayKEGG_HEDGEHOG_SIGNALING_PATHWAY

SHH IHH

1.79e-0356162M1053
PathwayREACTOME_HEDGEHOG_LIGAND_BIOGENESIS

SHH IHH

2.20e-0362162MM15181
PathwayREACTOME_HEDGEHOG_LIGAND_BIOGENESIS

SHH IHH

2.41e-0365162M27439
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

ST13P5 ST13

3.03e-0373162MM14948
PathwayREACTOME_HEDGEHOG_ON_STATE

SHH IHH

3.71e-0381162MM15225
PathwayREACTOME_HEDGEHOG_ON_STATE

SHH IHH

4.18e-0386162M27497
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

ST13P5 ST13

4.76e-0392162MM14951
PathwayREACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS

SHH IHH

4.97e-0394162M797
PathwayREACTOME_GASTRULATION

SHH IHH

9.17e-03129162M46433
Pubmed

Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans.

SHH ATOH1 IHH

3.94e-081319318632939
Pubmed

Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development.

ATOH7 ATOH1

2.83e-07219211889557
Pubmed

Hedgehog signaling regulates expansion of pancreatic epithelial cells.

SHH IHH

2.83e-07219215766752
Pubmed

Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond.

SHH IHH

2.83e-07219228574612
Pubmed

Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction.

SHH IHH

2.83e-07219229088246
Pubmed

Opposite expression patterns of Sonic hedgehog and Indian hedgehog are associated with aberrant methylation status of their promoters in colorectal cancers.

SHH IHH

2.83e-07219220854074
Pubmed

Combining hedgehog signaling inhibition with focal irradiation on reduction of pancreatic cancer metastasis.

SHH IHH

2.83e-07219223468532
Pubmed

Cholesterol modification of hedgehog signaling proteins in animal development.

SHH IHH

2.83e-0721928824192
Pubmed

Distinct expression patterns of hedgehog ligands between cultured and primary colorectal cancers are associated with aberrant methylation of their promoters.

SHH IHH

2.83e-07219219856079
Pubmed

Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling.

SHH IHH

2.83e-07219224344235
Pubmed

IHH, SHH, and primary cilia mediate epithelial-stromal cross-talk during decidualization in mice.

SHH IHH

2.83e-07219236853961
Pubmed

Hedgehog can drive terminal differentiation of amniote slow skeletal muscle.

SHH IHH

2.83e-07219215238161
Pubmed

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours.

SHH IHH

2.83e-07219214520411
Pubmed

New insight into hedgehog signaling in hematological malignancies.

SHH IHH

2.83e-07219224991722
Pubmed

Increased production of sonic hedgehog by ballooned hepatocytes.

SHH IHH

2.83e-07219221547909
Pubmed

St13 protects against disordered acinar cell arachidonic acid pathway in chronic pancreatitis.

ST13P5 ST13

2.83e-07219235562743
Pubmed

The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients.

SHH IHH

2.83e-07219226201092
Pubmed

Differential requirements for shh in mammary tissue and hair follicle morphogenesis.

SHH IHH

2.83e-07219212217324
Pubmed

LRP2 Acts as SHH Clearance Receptor to Protect the Retinal Margin from Mitogenic Stimuli.

SHH ATOH7 IHH

3.57e-072619326439398
Pubmed

pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development.

SHH ATOH1 IHH

5.56e-073019317257418
Pubmed

Sonic hedgehog (SHH) promotes the differentiation of mouse cochlear neural progenitors via the Math1-Brn3.1 signaling pathway in vitro.

SHH ATOH1

8.48e-07319219908278
Pubmed

Hedgehog signaling maintains resident hepatic progenitors throughout life.

SHH IHH

8.48e-07319216322088
Pubmed

Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels.

SHH IHH

8.48e-07319221537345
Pubmed

[Hedgehog signaling pathway and its impact on development of cancer therapy].

SHH IHH

8.48e-07319218788453
Pubmed

Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation.

SHH IHH

8.48e-07319219109233
Pubmed

Correlation Between Hedgehog (Hh) Protein Family and Brain-Derived Neurotrophic Factor (BDNF) in Autism Spectrum Disorder (ASD).

SHH IHH

8.48e-07319226691363
Pubmed

The adventures of Sonic Hedgehog in development and repair. I. Hedgehog signaling in gastrointestinal development and disease.

SHH IHH

8.48e-07319218063705
Pubmed

The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides.

SHH IHH

8.48e-07319211476578
Pubmed

Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma.

SHH ATOH1

8.48e-07319219965762
Pubmed

The hedgehog signaling pathway in the mouse ovary.

SHH IHH

8.48e-07319217392501
Pubmed

The world according to hedgehog.

SHH IHH

8.48e-0731929009843
Pubmed

Conserved regulation of Math5 and Math1 revealed by Math5-GFP transgenes.

ATOH7 ATOH1

8.48e-07319217900924
Pubmed

Genetic mosaic analysis reveals that GATA-4 is required for proper differentiation of mouse gastric epithelium.

SHH IHH

8.48e-07319211784093
Pubmed

LKB1 Regulates Cerebellar Development by Controlling Sonic Hedgehog-mediated Granule Cell Precursor Proliferation and Granule Cell Migration.

SHH ATOH1

8.48e-07319226549569
Pubmed

Developmental mechanisms underlying polydactyly in the mouse mutant Doublefoot.

SHH IHH

8.48e-07319212587916
Pubmed

Hedgehog signal transduction: from flies to vertebrates.

SHH IHH

8.48e-07319210579908
Pubmed

A new role for Hedgehogs in juxtacrine signaling.

SHH IHH

8.48e-07319224342078
Pubmed

Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic target.

SHH IHH

8.48e-07319219074837
Pubmed

Evolution of the hedgehog gene family.

SHH IHH

8.48e-0731928849902
Pubmed

Comparative biological responses to human Sonic, Indian, and Desert hedgehog.

SHH IHH

8.48e-07319211472839
Pubmed

Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium.

SHH ATOH1 IHH

1.06e-063719323266329
Pubmed

Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells.

SHH ATOH1

1.70e-06419226999738
Pubmed

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

SHH IHH

1.70e-0641928595881
Pubmed

Stromal Hedgehog pathway activation by IHH suppresses lung adenocarcinoma growth and metastasis by limiting reactive oxygen species.

SHH IHH

1.70e-06419232108165
Pubmed

Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer.

SHH IHH

1.70e-06419222486854
Pubmed

Characterization of the chromosome 1q41q42.12 region, and the candidate gene DISP1, in patients with CDH.

SHH IHH

1.70e-06419220799323
Pubmed

Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina.

SHH IHH

1.70e-0641929053312
Pubmed

Downregulation of hedgehog ligands in human simple steatosis may protect against nonalcoholic steatohepatitis: Is TAZ a crucial regulator?

SHH IHH

1.70e-06419231087761
Pubmed

Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite.

SHH IHH

1.70e-06419211572986
Pubmed

Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis.

SHH IHH

1.70e-06419212917489
Pubmed

Retinal Input Is Required for the Maintenance of Neuronal Laminae in the Ventrolateral Geniculate Nucleus.

SHH ATOH7

1.70e-06419239160068
Pubmed

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.

SHH IHH

1.70e-0641927916661
Pubmed

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors.

SHH IHH

1.70e-06419227694322
Pubmed

Overlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesis.

SHH IHH

1.70e-0641929858693
Pubmed

The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development.

SHH IHH

2.82e-06519210804186
Pubmed

Functional compensation in Hedgehog signaling during mouse prostate development.

SHH IHH

2.82e-06519216707121
Pubmed

Shh expression is required for embryonic hair follicle but not mammary gland development.

SHH IHH

2.82e-06519214623238
Pubmed

Products, genetic linkage and limb patterning activity of a murine hedgehog gene.

SHH IHH

2.82e-0651927720571
Pubmed

Developmental pathways in breast cancer and breast tumor-initiating cells: therapeutic implications.

SHH IHH

2.82e-06519222123293
Pubmed

Hedgehog and patched gene expression in adult ocular tissues.

SHH IHH

2.82e-0651929237688
Pubmed

Hedgehog signal activation coordinates proliferation and differentiation of fetal liver progenitor cells.

SHH IHH

2.82e-06519219559697
Pubmed

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein.

SHH IHH

2.82e-06519210050855
Pubmed

All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.

SHH IHH

2.82e-06519220519495
Pubmed

An Nfic-hedgehog signaling cascade regulates tooth root development.

SHH IHH

2.82e-06519226293299
Pubmed

Molecular signaling in intervertebral disk development.

SHH IHH

2.82e-06519215936916
Pubmed

Characterization of FAM10A4, a member of the ST13 tumor suppressor gene family that maps to the 13q14.3 region associated with B-Cell leukemia, multiple myeloma, and prostate cancer.

ST13P5 ST13P4

2.82e-06519212079276
Pubmed

Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor.

SHH IHH

4.24e-06619220978073
Pubmed

Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo.

SHH IHH

4.24e-0661927589793
Pubmed

Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney.

SHH IHH

4.24e-06619212399320
Pubmed

Use of a Conditional Ubr5 Mutant Allele to Investigate the Role of an N-End Rule Ubiquitin-Protein Ligase in Hedgehog Signalling and Embryonic Limb Development.

SHH IHH

4.24e-06619227299863
Pubmed

The dynamics of native Atoh7 protein expression during mouse retinal histogenesis, revealed with a new antibody.

ATOH7 ATOH1

4.24e-06619229225067
Pubmed

Cdc42 regulates cranial suture morphogenesis and ossification.

SHH IHH

4.24e-06619230853186
Pubmed

Restriction of sonic hedgehog signalling during early tooth development.

SHH IHH

4.24e-06619215151988
Pubmed

A genetic screen for mutations that affect cranial nerve development in the mouse.

SHH ATOH1

4.24e-06619216354937
Pubmed

Overgrowth of a mouse model of Simpson-Golabi-Behmel syndrome is partly mediated by Indian hedgehog.

SHH IHH

4.24e-06619219590577
Pubmed

A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve.

SHH IHH

4.24e-06619210357934
Pubmed

Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate.

SHH IHH

4.24e-06619225362352
Pubmed

A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development.

SHH IHH

4.24e-06619212385751
Pubmed

Hedgehog-Gli pathway activation during kidney fibrosis.

SHH IHH

4.24e-06619222342522
Pubmed

Glypican-6 promotes the growth of developing long bones by stimulating Hedgehog signaling.

SHH IHH

5.93e-06719228696225
Pubmed

Hedgehog signaling in the posterior region of the mouse gastrula suggests manifold roles in the fetal-umbilical connection and posterior morphogenesis.

SHH IHH

5.93e-06719222016185
Pubmed

Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice.

SHH IHH

5.93e-0671929152005
Pubmed

Disruption of Scube2 Impairs Endochondral Bone Formation.

SHH IHH

5.93e-06719225639508
Pubmed

Characterization of two patched receptors for the vertebrate hedgehog protein family.

SHH IHH

5.93e-0671929811851
Pubmed

Role of CDMP-1 in skeletal morphogenesis: promotion of mesenchymal cell recruitment and chondrocyte differentiation.

SHH IHH

5.93e-0671929885252
Pubmed

Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells.

SHH IHH

5.93e-06719212195432
Pubmed

Timing of androgen receptor disruption and estrogen exposure underlies a spectrum of congenital penile anomalies.

SHH IHH

7.90e-06819226598695
Pubmed

Stomach development is dependent on fibroblast growth factor 10/fibroblast growth factor receptor 2b-mediated signaling.

SHH IHH

7.90e-06819216618415
Pubmed

Neural Hedgehog signaling maintains stem cell renewal in the sensory touch dome epithelium.

SHH ATOH1

7.90e-06819226015562
Pubmed

Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1.

SHH IHH

7.90e-06819210529434
Pubmed

Gli1 is not required for Pdgfralpha expression during mouse embryonic development.

SHH IHH

7.90e-06819215811134
Pubmed

Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum.

SHH ATOH1

7.90e-06819215183722
Pubmed

Some distal limb structures develop in mice lacking Sonic hedgehog signaling.

SHH IHH

1.02e-05919211118883
Pubmed

Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4.

SHH IHH

1.02e-05919217881493
Pubmed

Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches.

SHH IHH

1.02e-05919225842978
Pubmed

Collagen XXVII organises the pericellular matrix in the growth plate.

COL27A1 IHH

1.02e-05919222206015
Pubmed

Gli3 null mice display glandular overgrowth of the developing stomach.

SHH IHH

1.02e-05919216247775
Pubmed

Prickle1 stunts limb growth through alteration of cell polarity and gene expression.

SHH IHH

1.02e-05919223913870
Pubmed

Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation.

SHH IHH

1.02e-05919220570969
Pubmed

Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma.

SHH ATOH1

1.02e-05919231851932
InteractionST13P5 interactions

ST13P5 ST13P4 ST13

1.55e-0712193int:ST13P5
InteractionST13P4 interactions

ST13P5 ST13P4 ST13

6.82e-0719193int:ST13P4
InteractionHHIP interactions

SHH IHH

3.77e-0510192int:HHIP
InteractionPTCH2 interactions

SHH IHH

1.58e-0420192int:PTCH2
InteractionZMYND10 interactions

CLK1 RNF181

1.92e-0422192int:ZMYND10
GeneFamilyEndogenous ligands|Matrix metallopeptidases

MMP17 MMP21

1.11e-0424122891
GeneFamilyBasic helix-loop-helix proteins

ATOH7 ATOH1

2.33e-03110122420
CoexpressionNABA_MATRISOME

SHH MMP17 MMP21 COL27A1 IHH ASTL

5.62e-051008196MM17056
CoexpressionNABA_MATRISOME

SHH MMP17 MMP21 COL27A1 IHH ASTL

6.20e-051026196M5889
CoexpressionNABA_MATRISOME_ASSOCIATED

SHH MMP17 MMP21 IHH ASTL

1.46e-04738195MM17058
CoexpressionNABA_MATRISOME_ASSOCIATED

SHH MMP17 MMP21 IHH ASTL

1.59e-04751195M5885
ToppCelldroplet-Kidney-nan-18m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMP17 PLA2R1 L3MBTL1

3.41e-0516917387116c33c5ca8cb1862e103e5607b1df4d264569
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHH ATOH1 IHH

3.71e-05174173e7cca4b6a3935fad61cf2a3d9984ab1ffa1a9447
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHH ATOH1 IHH

3.71e-05174173ad5b56f0ace6455c033834b931ec870cc0dc9290
ToppCellAT1_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

ATOH7 PLA2R1 IHH

4.04e-051791731603117b52623663458a977c94bf7f9f6c1114b8
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l30|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MMP17 COL27A1 IHH

4.60e-051871736f7f293c9cf35261e0e3614e46ec1fb00a701b63
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Chrm2-Inhibitory_Gad1Gad2_Htr3a.Chrm2_(Interneuron,__(candidate_CGE-derived_10))|Hippocampus / BrainAtlas - Mouse McCarroll V32

SHH L3MBTL1

2.12e-0457172e61b10212685e5217550db0812141a1f3f6567c8
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Chrm2|Hippocampus / BrainAtlas - Mouse McCarroll V32

SHH L3MBTL1

2.12e-04571725ae53d915bee8a5fc7936d2a46517da1b6abbf79
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Chrm2-Inhibitory_Gad1Gad2_Htr3a.Chrm2_(Interneuron,__(candidate_CGE-derived_10))-|Hippocampus / BrainAtlas - Mouse McCarroll V32

SHH L3MBTL1

2.12e-0457172f5edb5e8eddc51e0b8040e88baa5d8971871f9ea
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-T-T_CD8-MAIT|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

RSKR ASTL

8.01e-0411117258a1536cf63568ffc985baefa495af659dd9ba88
ToppCellPND28-Epithelial-Epithelial_Airway-Neurosecretory|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SHH ATOH7

1.36e-0314517276f0cde9acdc3ad5948c007dccf312665972c9e6
ToppCellPND28-Epithelial-Epithelial_Airway-Neurosecretory-Secretory|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SHH ATOH7

1.36e-0314517231af9fce1dcd7e8ae1604476598e099232017ee9
ToppCellPND28-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SHH ATOH7

1.36e-031451729b69bfdbf91ef197b4c483617aa67498d9d2cd79
ToppCellnormal_Lymph_Node-Myeloid_cells-CD163+CD14+_DCs|Myeloid_cells / Location, Cell class and cell subclass

MMP17 CLK1

1.43e-03149172a34d095b8e0fe59d69d84e4fd2fe4ccb82f92e4f
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHH ATOH1

1.43e-03149172d259e9137109eeb2662022f0915ca463f5bebdfe
ToppCellTCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue-Urothelial_normal_tissue-4|TCGA-Bladder / Sample_Type by Project: Shred V9

SHH ASTL

1.45e-03150172bcb99c6fa81052556ab30f9db5875fccf1ae724b
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Mucinous_Lepidic_Adenocarcinoma|TCGA-Lung / Sample_Type by Project: Shred V9

ATOH1 IHH

1.47e-0315117260bb6de5d9b13402bc18cb6d5e51078326dff8e2
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Mucinous_Lepidic_Adenocarcinoma-7|TCGA-Lung / Sample_Type by Project: Shred V9

ATOH1 IHH

1.47e-031511723dfa1d89975ffaa45b26833538244153d50c60a7
ToppCelldroplet-Liver-Hepatocytes-24m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL27A1 IHH

1.49e-03152172c21e2152b0130485659051d8fb7fb4589d1ec997
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

CLK1 RSKR

1.53e-03154172874b1220337276489a89fcc9a39bc81ba6b68baf
ToppCellEntopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Junb_(Mural,_IEG+)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

CLK1 PLA2R1

1.57e-031561725df19a235843829f5a1a90ca21b0964ef8b4e115
ToppCellEntopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Junb_(Mural,_IEG+)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

CLK1 PLA2R1

1.57e-03156172029ba0832ee9c4a2c85620e4df2260e02d86b45c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MMP17 IHH

1.65e-0316017214dfa519e68bab4bce890ddb66fa7763f18d9f19
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MMP17 IHH

1.65e-03160172bba1486faaad5299e10f4fe17c6d149c28dc2560
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MMP17 IHH

1.65e-031601725b7789d4668ed7732babedc32d812233b430e0bd
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MMP17 IHH

1.65e-03160172839bbdfd4e4c7b48260c8bfb7670378634405e1d
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHH IHH

1.73e-03164172ea02ca343b2b28e437304de889e2ae1e315a1197
ToppCellEndothelial-B-HP_01|World / lung cells shred on cell class, cell subclass, sample id

PLA2R1 L3MBTL1

1.75e-0316517210087d8bd2985906ef19547fe77eb178ae5e1638
ToppCell368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-|368C / Donor, Lineage, Cell class and subclass (all cells)

ATOH7 PCLO

1.77e-031661724d63c758d46e73311b864148c646bf081498dee7
ToppCell368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)|368C / Donor, Lineage, Cell class and subclass (all cells)

ATOH7 PCLO

1.77e-031661724160ccf9291072a6e2782f9ad141bc9a9747f3ad
ToppCellTCGA-Colorectal|World / Sample_Type by Project: Shred V9

ATOH1 IHH

1.77e-03166172c018cd8c7a82251c67e3dc812d4d21e527a43456
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IHH ASTL

1.80e-03167172720dc5855c856b478b5ca90156b30bfcc5518d60
ToppCellPCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SHH IHH

1.80e-0316717225af48c640e67848594f5902867ba325fc105da4
ToppCell10x3'2.3-week_17-19-Myeloid_macrophage-stroma-osteoclast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

COL27A1 THOP1

1.82e-031681721993e7fb6d7291d448219c813cb968ddad270bb5
ToppCell368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ATOH7 PCLO

1.82e-03168172403aba73a0f9ffb32252288d075fad8a588ca440
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLA2R1 COL27A1

1.82e-03168172d19a115365c5415e51c039718d7669de788fcf33
ToppCell368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ATOH7 PCLO

1.82e-03168172e870d2e69316406f45112ed0bf324b24f902a99e
ToppCell3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ATOH1 IHH

1.86e-031701729bea81031cdfe45e8cddac3a3afd9ca6c331c45a
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MMP17 COL27A1

1.86e-031701725570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ATOH1 IHH

1.86e-031701722c5a1469e5743870e96e6c2cc92f0c5096b79f51
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Penk_Col27a1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MMP17 COL27A1

1.88e-03171172d07e2c5f7d7f12c68860d4161d76372de174f1d8
ToppCellfacs-Aorta-Heart-24m-Epithelial|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATOH1 IHH

1.92e-0317317286aa15cf5c450465290de1c3dd9ff9d355d9cbee
ToppCellfacs-Aorta-Heart-24m-Epithelial-epithelial_cell|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATOH1 IHH

1.92e-031731722216e36c77cb3b531508f897c1e7e01b94037d5e
ToppCellfacs-Aorta-Heart-24m-Epithelial-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATOH1 IHH

1.92e-03173172a3a09fe5cdb9e91e0880e247bf8d974fe29c6fa8
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MMP21 COL27A1

1.97e-03175172910a075ccaf79de22338ecf321fa0a867f3d7d75
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLA2R1 IHH

1.97e-031751726759d200a133034756de9cdf2d5daceca927aac9
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MMP21 COL27A1

1.97e-03175172f0c2eb82e17e8aec2cfa5d83169178f409cc1abc
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Paneth|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ATOH1 IHH

1.97e-03175172bffa623511ceb0b9bf76d87f9a10cfadfe0e940f
ToppCell10x5'v1-week_14-16-Hematopoietic-HSC/MPP_and_pro-MPP_myeloid|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SHH ATOH7

1.97e-03175172df369b96a780272ed52e23c8627fc63c22efa445
ToppCell5'-Adult-Distal_Rectal-Epithelial-goblet-BEST2+_Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHH ATOH1

1.97e-03175172019ea30ac55748463d7917abf3d3f0e804189bfd
ToppCellfacs-Lung-nan-3m-Epithelial-club_cell_of_bronchiole|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHH PCLO

2.01e-03177172e5070934c674a46e070b0d52b9a374516bf6aea1
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-chondrocyte|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

COL27A1 IHH

2.01e-03177172915b848d789051a1c3bc6f6dc86955bb752276ab
ToppCellfacs-Lung-nan-3m-Epithelial-Club_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHH PCLO

2.01e-03177172b37d821f4f3204daf7c568ac17a0af0ba97273d6
ToppCell5'-Adult-Distal_Rectal-Epithelial-goblet|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHH ATOH1

2.04e-031781729099b47e0756d6a1b7ba1c6aa7b47c5425f649e0
ToppCell10x5'v1-week_14-16-Myeloid_macrophage-stroma-osteoclast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

COL27A1 THOP1

2.04e-03178172a28683690ab8a60eb18f3ef87ea85da4e95b22df
ToppCellwk_15-18-Mesenchymal-Chondrocyte-ASPN+_chondrocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PLA2R1 COL27A1

2.04e-03178172a55130670aa95a87b833dd3cd2de461d779e4c06
ToppCellPBMC-Severe-cDC_11|Severe / Compartment, Disease Groups and Clusters

PLA2R1 COL27A1

2.04e-031781720667abc05eb2254710b9c648c65b7cfdfe7831b7
ToppCell(3)_Chondrocytes-(32)_Chondro-prehyper-2|World / Cell class and subclass of bone marrow stroma cells in homeostatis

COL27A1 IHH

2.04e-03178172c569a406c3ae183a278d8540e8eba58f4f26c5b0
ToppCellfacs-Brain_Myeloid-Cortex-24m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATOH1 IHH

2.06e-03179172bc93883c2094f2e5bfed79facd4994a23968d875
ToppCellPCW_10-12-Endothelial-Endothelial_mature-lymphatic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MMP17 PCLO

2.06e-03179172ab3d08b51cd7a37582305615ee221c7a2af83b40
ToppCellfacs-Brain_Myeloid-Cortex-24m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATOH1 IHH

2.06e-031791720cef6d2eab2015cac0dd340532b24bfec9707330
ToppCellPCW_10-12-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MMP17 PCLO

2.06e-0317917235fe9961e228ce255e3317fc244efa35b5adbf8b
ToppCellfacs-Brain_Myeloid-Cortex-24m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATOH1 IHH

2.06e-03179172065241799cea30da62cb3b6f2f1970bd1b0f4e2b
ToppCellfacs-Brain_Myeloid-Cortex-24m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATOH1 IHH

2.06e-03179172bb2410b3934fcc53396b96b48e0d9843df159b89
ToppCellMesenchymal_cells-Chondrocytes|Mesenchymal_cells / Lineage and Cell class

COL27A1 IHH

2.08e-031801726e399368430ef3afa9ce1ef0ed90f614ccef9987
ToppCellCOVID-19-kidney-PCT-S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

COL27A1 PCLO

2.08e-03180172358923e4228035a3e90e2957392089219e90dcd7
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMP17 COL27A1

2.13e-03182172d568a8aec7e27ce632e248baea2ccd0e8dd255ac
ToppCellwk_20-22-Mesenchymal-Chondrocyte-Resting_chondrocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

COL27A1 PCLO

2.13e-0318217203a5a02acd48f0eb210485348bfe0cd21f486215
ToppCell10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-LMPP|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

COL27A1 L3MBTL1

2.13e-0318217269b5cae6fe3bbb0fc60bd2f71b6cfa6cbb0b00ee
ToppCellE12.5-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SHH COL27A1

2.13e-03182172204530444e35d4977a7239ac176f477e9e5c29ab
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMP17 COL27A1

2.13e-0318217282ca6d5ed48b4c487ce00b9309255abb8f20b61d
ToppCellChildren_(3_yrs)-Immune-enucleated_erythrocyte-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

SHH PLA2R1

2.13e-031821723fddadb2ff75013ec6eeb415872667a6bae1da2d
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMP17 COL27A1

2.13e-03182172e89cc30db8e5c77a8bbddd1d5a4b5af09f1ccd67
ToppCellmild-B_cell|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PLA2R1 L3MBTL1

2.15e-03183172175aaf8fbbff52eab87d78a49d5ab02cd489c438
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL27A1 PCLO

2.15e-0318317284b64cf728629c3af9a8d2ed15b93adf562c54b8
ToppCelldroplet-Kidney-nan-21m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMP17 PLA2R1

2.15e-03183172f55081068213cc1cdb2acad58ff10f6b48b44c72
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-Double_negative_Thymocyte,_DN4_(Cd8-,_Cd4-),_some_undergoing_VDJ_recombination_|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST13 ASTL

2.15e-03183172a0a3e4d07ac73dbbb1e019fd11e88ccffe6cf2ca
ToppCellAT1-AT2_cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

SHH PCLO

2.15e-031831726821dca076318115d360ff426eb1218cfe104063
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ATOH1 IHH

2.17e-03184172886d2d9bf2fe31207f17e3edc309ef44029924e1
ToppCellPCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SHH IHH

2.17e-03184172fa4915b0498f3069fd5ef497286445528f75187e
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-goblet|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ATOH1 IHH

2.17e-03184172936b39377eebea3961d702532779f6cd27953be7
ToppCellMesenchymal_cells-Chondrocytes|World / Lineage and Cell class

COL27A1 IHH

2.17e-031841721e03f9f08de5ad4d45388a95afad9f23ff0d0e28
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCLO IHH

2.20e-03185172d42f6722a6771752cd744146a09e2ead9b7252bc
ToppCellCOVID-19-kidney-Mito-rich_PCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

COL27A1 PCLO

2.20e-031851721bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCellPCW_13-14-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MMP17 PCLO

2.20e-031851723be9e05b929ac4d956b1d53284072f668a6c1959
ToppCellPCW_13-14-Endothelial-Endothelial_mature-lymphatic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MMP17 PCLO

2.20e-03185172c3dd64a726cb8a1fe048683c266b7532a714a52e
ToppCell10x3'2.3-week_14-16-Myeloid_macrophage-stroma-osteoclast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

COL27A1 THOP1

2.20e-031851725ed49b6d8214c6119355a6d3ee4e25d40bcc0c53
ToppCellwk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

COL27A1 IHH

2.20e-03185172636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCellfacs-BAT-Fat-24m-Epithelial-Epcam+|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATOH1 IHH

2.22e-03186172b18d7398279a2d42414318aeb70514fd402f5a0a
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-chondrocyte|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

COL27A1 IHH

2.22e-0318617280a0a42ca8585cdb1dda57a18c254316a126ee64
ToppCelldroplet-Heart-HEART-1m-Neuronal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMP17 COL27A1

2.22e-03186172fddc6b93f98b10aaf8d4ebc142b46d8213f3129d
ToppCell10x5'v1-week_12-13-Myeloid_macrophage-stroma-osteoclast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

COL27A1 THOP1

2.22e-03186172c9dfcf7bba7e5ef97ad5d9b7084fba932c91ab68
ToppCellnormal_Lung-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

THOP1 RSKR

2.24e-03187172a3592f056e1c2f82ba325fea2ecc4dd6c6347c81
ToppCell15-Airway-Epithelial-Neuroendocrine|Airway / Age, Tissue, Lineage and Cell class

PCLO IHH

2.24e-03187172a7d2f30fe0f19e63d44603ece9890acd11b45e52
ToppCelldroplet-Bladder-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHH CLK1

2.24e-03187172663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCellnormal_Lung-Myeloid_cells-pDCs|normal_Lung / Location, Cell class and cell subclass

THOP1 RSKR

2.24e-03187172d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMP17 PLA2R1

2.24e-03187172dba4924d914a7dcd4901142684ba920c2404860b
ToppCellCOVID-19-kidney-Fibroblast-1|COVID-19 / Disease (COVID-19 only), tissue and cell type

PLA2R1 COL27A1

2.24e-0318717276bfe8c42430a230a8bdf299575c444fb7780f24
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMP17 PLA2R1

2.24e-031871729688141beef4f62613d7a810c5872ccb9afc1a71
ToppCellPCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SHH PCLO

2.27e-031881720d86044bc340e3efb90d0022dd299873639d831c
ToppCellPCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SHH PCLO

2.27e-03188172beb2df2332a46cc81b10e8e29fc9829020111f03
Diseaseautism spectrum disorder (is_marker_for)

SHH IHH

7.37e-067182DOID:0060041 (is_marker_for)
Diseaseprimary bacterial infectious disease (implicated_via_orthology)

SHH IHH

1.26e-059182DOID:0050338 (implicated_via_orthology)
Diseaserosacea severity measurement

ST13P5 PCLO

3.58e-03147182EFO_0009180

Protein segments in the cluster

PeptideGeneStartEntry
HVLGFWHEHTRADRD

ASTL

186

Q6HA08
YFHHDRLDWDEHSSA

CLK1

411

P49759
AHRLLGHWEEAAHDL

ST13P5

191

Q8NFI4
AHRLLGHWEEAAHDL

ST13

191

P50502
EDAGRRHSWHDEDDE

PCLO

1621

Q9Y6V0
RHSWHDEDDEAFDES

PCLO

1626

Q9Y6V0
HGYDFWIDADHPDIH

L3MBTL1

556

Q9Y468
HAWRLGDIHFDDDEH

MMP21

251

Q8N119
DLEELWELRGHHYLH

RSKR

51

Q96LW2
DLAGRLHHSWHFAGE

GOLGA6L2

166

Q8N9W4
HAEEWAEVKELGDHH

ATOH1

6

Q92858
RDWVGLHCEHFGRDH

ATOH7

106

Q8N100
AFDLDMHDGRWHHLA

COL27A1

146

Q8IZC6
EGWDEDGHHSEESLH

IHH

131

Q14623
KAHRLLGHWEEAAHD

ST13P4

186

Q8IZP2
EGWDEDGHHSEESLH

SHH

126

Q15465
DFEDLGLVVDWDHHL

RNF181

36

Q9P0P0
HHTAGDTHFDDDEAW

MMP17

216

Q9ULZ9
HQWHHECTREGREDD

PLA2R1

186

Q13018
FHHEEGASAWHEDVR

THOP1

381

P52888