Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	SMG1 MET FAM20C PIM1 MAST1 DGKZ DGKH PRKDC CDK1 LRRK1 MERTK	4.40e-05	709	72	11	GO:0016773
GeneOntologyMolecularFunction	kinase activity	SMG1 MET FAM20C PIM1 MAST1 DGKZ DGKH PRKDC CDK1 LRRK1 MERTK	8.60e-05	764	72	11	GO:0016301
GeneOntologyMolecularFunction	protein kinase activity	SMG1 MET FAM20C PIM1 MAST1 PRKDC CDK1 LRRK1 MERTK	2.96e-04	600	72	9	GO:0004672
GeneOntologyMolecularFunction	protein serine kinase activity	SMG1 FAM20C PIM1 MAST1 PRKDC CDK1 LRRK1	3.31e-04	363	72	7	GO:0106310
GeneOntologyMolecularFunction	tRNA-specific adenosine deaminase activity	ADAT3 ADAR	3.54e-04	8	72	2	GO:0008251
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	SMG1 MET FAM20C PIM1 MAST1 DGKZ DGKH PRKDC CDK1 LRRK1 MERTK	5.07e-04	938	72	11	GO:0016772
GeneOntologyMolecularFunction	ATP-dependent diacylglycerol kinase activity	DGKZ DGKH	6.91e-04	11	72	2	GO:0004143
GeneOntologyMolecularFunction	adenosine deaminase activity	ADAT3 ADAR	9.75e-04	13	72	2	GO:0004000
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	SMG1 FAM20C PIM1 MAST1 PRKDC CDK1 LRRK1	1.12e-03	446	72	7	GO:0004674
GeneOntologyBiologicalProcess	nuclear export	SMG1 MDN1 RAPGEF3 DDX25 NUP188 XPO1 ADAR	4.12e-06	185	73	7	GO:0051168
GeneOntologyBiologicalProcess	nuclear transport	TNPO1 SMG1 MDN1 RAPGEF3 DDX25 NUP188 CDK1 XPO1 ADAR	7.32e-06	378	73	9	GO:0051169
GeneOntologyBiologicalProcess	nucleocytoplasmic transport	TNPO1 SMG1 MDN1 RAPGEF3 DDX25 NUP188 CDK1 XPO1 ADAR	7.32e-06	378	73	9	GO:0006913
Domain	ARM-type_fold	TNPO1 SMG1 USP24 PRKDC NUP188 XPO1 HUWE1 MEI1	5.22e-05	339	73	8	IPR016024
Domain	FATC	SMG1 PRKDC	1.50e-04	5	73	2	PF02260
Domain	HEAT_REPEAT	TNPO1 SMG1 PRKDC XPO1	1.62e-04	70	73	4	PS50077
Domain	FAT	SMG1 PRKDC	2.24e-04	6	73	2	PS51189
Domain	FATC	SMG1 PRKDC	2.24e-04	6	73	2	PS51190
Domain	FATC_dom	SMG1 PRKDC	2.24e-04	6	73	2	IPR003152
Domain	PIK_FAT	SMG1 PRKDC	2.24e-04	6	73	2	IPR014009
Domain	FATC	SMG1 PRKDC	2.24e-04	6	73	2	SM01343
Domain	ARM-like	TNPO1 SMG1 PRKDC XPO1 HUWE1 MEI1	6.54e-04	270	73	6	IPR011989
Domain	DAGK_acc	DGKZ DGKH	6.64e-04	10	73	2	PF00609
Domain	Diacylglycerol_kin_accessory	DGKZ DGKH	6.64e-04	10	73	2	IPR000756
Domain	DAGKa	DGKZ DGKH	6.64e-04	10	73	2	SM00045
Domain	DNA-bd_dom_put	SKOR1 FARSB	8.10e-04	11	73	2	IPR009061
Domain	Kinase-like_dom	SMG1 MET PIM1 MAST1 PRKDC CDK1 LRRK1 MERTK	1.23e-03	542	73	8	IPR011009
Domain	IMPORTIN_B_NT	TNPO1 XPO1	1.33e-03	14	73	2	PS50166
Domain	DAGKc	DGKZ DGKH	1.33e-03	14	73	2	SM00046
Domain	HEAT	TNPO1 PRKDC XPO1	1.52e-03	58	73	3	IPR000357
Domain	Diacylglycerol_kinase_cat_dom	DGKZ DGKH	1.53e-03	15	73	2	IPR001206
Domain	IBN_N	TNPO1 XPO1	1.53e-03	15	73	2	PF03810
Domain	DAGK_cat	DGKZ DGKH	1.53e-03	15	73	2	PF00781
Domain	DAGK	DGKZ DGKH	1.53e-03	15	73	2	PS50146
Domain	PI3/4_kinase_CS	SMG1 PRKDC	1.53e-03	15	73	2	IPR018936
Domain	-	SMG1 PRKDC	1.75e-03	16	73	2	1.10.1070.11
Domain	IBN_N	TNPO1 XPO1	1.75e-03	16	73	2	SM00913
Domain	PI3Kc	SMG1 PRKDC	1.75e-03	16	73	2	SM00146
Domain	NAD/diacylglycerol_kinase	DGKZ DGKH	1.97e-03	17	73	2	IPR016064
Domain	Importin-beta_N	TNPO1 XPO1	1.97e-03	17	73	2	IPR001494
Domain	PI3/4_kinase_cat_dom	SMG1 PRKDC	2.21e-03	18	73	2	IPR000403
Domain	PI3_PI4_kinase	SMG1 PRKDC	2.21e-03	18	73	2	PF00454
Domain	PI3_4_KINASE_3	SMG1 PRKDC	2.21e-03	18	73	2	PS50290
Domain	PI3_4_KINASE_1	SMG1 PRKDC	2.21e-03	18	73	2	PS00915
Domain	PI3_4_KINASE_2	SMG1 PRKDC	2.21e-03	18	73	2	PS00916
Domain	PDEase	PDE8A PDE11A	2.47e-03	19	73	2	IPR023088
Domain	PDEase_I	PDE8A PDE11A	3.02e-03	21	73	2	PF00233
Domain	PDEASE_I	PDE8A PDE11A	3.02e-03	21	73	2	PS00126
Domain	PDEase_CS	PDE8A PDE11A	3.02e-03	21	73	2	IPR023174
Domain	-	PDE8A PDE11A	3.31e-03	22	73	2	1.10.1300.10
Domain	Quino_amine_DH_bsu	WDR86 LRRK1	3.31e-03	22	73	2	IPR011044
Domain	PDEase_catalytic_dom	PDE8A PDE11A	3.61e-03	23	73	2	IPR002073
Domain	HDc	PDE8A PDE11A	3.93e-03	24	73	2	SM00471
Domain	HD/PDEase_dom	PDE8A PDE11A	3.93e-03	24	73	2	IPR003607
Domain	HECT	HERC3 HUWE1	4.96e-03	27	73	2	PF00632
Domain	HECTc	HERC3 HUWE1	4.96e-03	27	73	2	SM00119
Domain	HECT_dom	HERC3 HUWE1	4.96e-03	27	73	2	IPR000569
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	FANCD2 TNPO1 MARS2 DCAF13 PDE12 MDN1 ERAL1 PIM1 FARSB TLN2 PRKDC NUP188 CDK1 XPO1 HUWE1 EDC4 STX16 ADAR	7.81e-10	1425	74	18	30948266
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FAM20C ARHGEF40 MDN1 MEGF6 PROM2 TMEM8B NISCH TLN2 PRKDC NUP188 LRRK1 HUWE1 EDC4 GBA2	7.60e-08	1105	74	14	35748872
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	FANCD2 TNPO1 ARHGEF40 PDE12 NISCH USP24 FARSB PRKDC NUP188 XPO1 HUWE1 EDC4 SLC27A3	8.85e-08	942	74	13	31073040
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	TNPO1 MDN1 ERAL1 USP24 PRKDC NUP188 CDK1 XPO1 HUWE1 EDC4 ADAR	1.07e-07	638	74	11	33239621
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	FANCD2 DCAF13 PDE12 FARSB PRKDC NUP188 CDK1 HUWE1 ALDH9A1 PRPF39 ADAR	2.84e-07	704	74	11	29955894
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	FANCD2 TNPO1 MDN1 ERAL1 USP24 TLN2 PRKDC CDK1 HUWE1 EDC4	4.38e-07	582	74	10	20467437
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	FANCD2 TNPO1 ERAL1 FARSB DGKZ PRKDC NUP188 CDK1 XPO1 HUWE1 ALDH9A1 SLC27A3	9.68e-07	974	74	12	28675297
Pubmed	TGFβ pathway is required for viable gestation of Fanconi anemia embryos.	FANCD2 PTPRC PRKDC	1.10e-06	10	74	3	36441774
Pubmed	Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure.	TNPO1 NUP188 XPO1 ADAR	1.63e-06	40	74	4	37516964
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	FANCD2 TNPO1 SMG1 MDN1 ERAL1 TRAPPC5 FARSB PRKDC NUP188 CDK1 XPO1 HUWE1 EDC4 STX16	1.82e-06	1440	74	14	30833792
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	FANCD2 TNPO1 PDE12 GSPT2 USP24 FARSB PRKDC NUP188 CDK1 XPO1 HUWE1 EDC4 ALDH9A1 PRPF39	2.05e-06	1455	74	14	22863883
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	TNPO1 MARS2 MET ARHGEF40 DCAF13 USP24 FARSB PRKDC NUP188 CDK1 XPO1 ALDH9A1 ADAR	3.21e-06	1297	74	13	33545068
Pubmed	Targeting an Achilles' heel of cancer with a WRN helicase inhibitor.	FANCD2 PRKDC	4.47e-06	2	74	2	24036544
Pubmed	FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway.	FANCD2 BRIP1	4.47e-06	2	74	2	26637282
Pubmed	PIM1 kinase promotes cell proliferation, metastasis and tumor growth of lung adenocarcinoma by potentiating the c-MET signaling pathway.	MET PIM1	4.47e-06	2	74	2	30583073
Pubmed	Macrophages and stromal cells phagocytose apoptotic bone marrow-derived B lineage cells.	PTPRC PECAM1	4.47e-06	2	74	2	15067047
Pubmed	CRM1 mediates the export of ADAR1 through a nuclear export signal within the Z-DNA binding domain.	XPO1 ADAR	4.47e-06	2	74	2	11604520
Pubmed	FANCJ/BRIP1 recruitment and regulation of FANCD2 in DNA damage responses.	FANCD2 BRIP1	4.47e-06	2	74	2	20676667
Pubmed	Functional identification of the hematopoietic stem cell niche in the ventral domain of the embryonic dorsal aorta.	PTPRC PECAM1	4.47e-06	2	74	2	17517650
Pubmed	Frontline Science: PECAM-1 (CD31) expression in naïve and memory, but not acutely activated, CD8+ T cells.	PECAM1 DGKZ	4.47e-06	2	74	2	30063264
Pubmed	The Fanconi anemia proteins FANCD2 and FANCJ interact and regulate each other's chromatin localization.	FANCD2 BRIP1	4.47e-06	2	74	2	25070891
Pubmed	Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining.	FANCD2 PRKDC	4.47e-06	2	74	2	16135554
Pubmed	The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling.	MET PIM1	4.47e-06	2	74	2	24777602
Pubmed	A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1.	TNPO1 ADAR	4.47e-06	2	74	2	24753571
Pubmed	Successful differentiation to T cells, but unsuccessful B-cell generation, from B-cell-derived induced pluripotent stem cells.	PTPRC PRKDC	4.47e-06	2	74	2	21135032
Pubmed	The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.	TNPO1 NUP188 XPO1	6.15e-06	17	74	3	10668806
Pubmed	Defining the membrane proteome of NK cells.	MDN1 PTPRC NISCH FARSB PRKDC NUP188 CDK1 XPO1 HUWE1 EDC4 ADAR SLC27A3	6.26e-06	1168	74	12	19946888
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TNPO1 DCAF13 MDN1 USP24 PRKDC NUP188 XPO1 HUWE1 EDC4	1.02e-05	653	74	9	22586326
Pubmed	Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability.	PIM1 CDK1	1.34e-05	3	74	2	12411508
Pubmed	Characterization of the thymic IL-7 niche in vivo.	PTPRC PECAM1	1.34e-05	3	74	2	19164539
Pubmed	Altered homeostasis and development of regulatory T cell subsets represent an IL-2R-dependent risk for diabetes in NOD mice.	PTPRC PRKDC	1.34e-05	3	74	2	29259102
Pubmed	RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1.	TNPO1 ADAR	1.34e-05	3	74	2	19124606
Pubmed	EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.	RAPGEF3 PRKDC	1.34e-05	3	74	2	18728186
Pubmed	Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.	TNPO1 XPO1	1.34e-05	3	74	2	22783232
Pubmed	Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells.	PRKDC CDK1	1.34e-05	3	74	2	9295339
Pubmed	The proepicardium delivers hemangioblasts but not lymphangioblasts to the developing heart.	PTPRC PECAM1	1.34e-05	3	74	2	17383624
Pubmed	ADAR1 is required for hematopoietic progenitor cell survival via RNA editing.	PRKDC ADAR	1.34e-05	3	74	2	19805087
Pubmed	Lack of large genomic deletions in BRIP1, PALB2, and FANCD2 genes in BRCA1/2 negative familial breast cancer.	FANCD2 BRIP1	1.34e-05	3	74	2	19504183
Pubmed	HUWE1-dependent DNA-PKcs neddylation modulates its autophosphorylation in DNA damage response.	PRKDC HUWE1	1.34e-05	3	74	2	32457294
Pubmed	Lack of Phenotypical and Morphological Evidences of Endothelial to Hematopoietic Transition in the Murine Embryonic Head during Hematopoietic Stem Cell Emergence.	PTPRC PECAM1	1.34e-05	3	74	2	27227884
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	FANCD2 MET FAM20C ZBTB20 MDN1 TRAPPC5 PRKDC NUP188 HUWE1 STX16 PRPF39	1.46e-05	1061	74	11	33845483
Pubmed	Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.	TNPO1 PRKDC CDK1 XPO1 PRPF39 ADAR	1.91e-05	258	74	6	21081666
Pubmed	Overview of PDEs and their regulation.	PDE12 PDE8A PDE11A	2.06e-05	25	74	3	17307970
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	TNPO1 MDN1 GSPT2 PRKDC CDK1 XPO1 HUWE1	2.31e-05	399	74	7	37536630
Pubmed	UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.	SMG1 TLN2 PRKDC CDK1 HUWE1 ALDH9A1	2.32e-05	267	74	6	33417871
Pubmed	LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.	MDN1 ZBTB43 PRKDC HUWE1	2.51e-05	79	74	4	26446488
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	FAM20C PDE12 MDN1 MEGF6 DGKH PRKDC NUP188 CDK1 HUWE1	2.63e-05	736	74	9	29676528
Pubmed	FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex.	FANCD2 BRIP1	2.67e-05	4	74	2	25659033
Pubmed	Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.	PTPRC SIRPG	2.67e-05	4	74	2	32294445
Pubmed	Mesenchymal cells with leukocyte and lymphendothelial characteristics in murine embryos.	PTPRC PECAM1	2.67e-05	4	74	2	16502417
Pubmed	FANCJ protein is important for the stability of FANCD2/FANCI proteins and protects them from proteasome and caspase-3 dependent degradation.	FANCD2 BRIP1	2.67e-05	4	74	2	26336824
Pubmed	Changes in the number of CD31-CD45-Sca-1+ cells and Shh signaling pathway involvement in the lungs of mice with emphysema and relevant effects of acute adenovirus infection.	PTPRC PECAM1	2.67e-05	4	74	2	28352167
Pubmed	Hemogenic endothelium generates mesoangioblasts that contribute to several mesodermal lineages in vivo.	PTPRC PECAM1	2.67e-05	4	74	2	24757004
Pubmed	CD4 raft association and signaling regulate molecular clustering at the immunological synapse site.	PTPRC TLN2	2.67e-05	4	74	2	15128768
Pubmed	PEG10 viral aspartic protease domain is essential for the maintenance of fetal capillary structure in the mouse placenta.	PTPRC PECAM1	2.67e-05	4	74	2	34559199
Pubmed	Gene expression profiling reveals activation of the FA/BRCA pathway in advanced squamous cervical cancer with intrinsic resistance and therapy failure.	FANCD2 BRIP1	2.67e-05	4	74	2	24708616
Pubmed	Defects of FA/BRCA pathway in lymphoma cell lines.	FANCD2 BRIP1	2.67e-05	4	74	2	19011769
Pubmed	ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility.	SMG1 DDX25	2.67e-05	4	74	2	32665638
Pubmed	Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia.	PTPRC PRKDC	2.67e-05	4	74	2	36848231
Pubmed	Endothelial cell talin1 is essential for embryonic angiogenesis.	PECAM1 TLN2	2.67e-05	4	74	2	21081121
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ARHGEF40 DCAF13 PDE12 MDN1 ERAL1 FARSB PRKDC CDK1 XPO1 HUWE1 ALDH9A1 ADAR	2.70e-05	1353	74	12	29467282
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	FANCD2 TNPO1 FARSB PRKDC NUP188 CDK1 XPO1 HUWE1	2.93e-05	571	74	8	37167062
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	TNPO1 MDN1 KRT71 NISCH FARSB PRKDC CDK1 XPO1 HUWE1 ALDH9A1 ADAR	3.03e-05	1149	74	11	35446349
Pubmed	DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.	PRKDC XPO1 HUWE1 ALDH9A1 ADAR	3.71e-05	175	74	5	25756610
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FANCD2 BRIP1 MDN1 PTPRC USP24 TLN2 PRKDC XPO1 HUWE1	3.88e-05	774	74	9	15302935
Pubmed	Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.	FANCD2 BRIP1 PRKDC CDK1	4.02e-05	89	74	4	18950845
Pubmed	Ubp-M serine 552 phosphorylation by cyclin-dependent kinase 1 regulates cell cycle progression.	CDK1 XPO1	4.45e-05	5	74	2	24013421
Pubmed	Mitogen-activated protein kinase ERK1/2 regulates the class II transactivator.	CDK1 XPO1	4.45e-05	5	74	2	18245089
Pubmed	PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2.	CDK1 LRRK1	4.45e-05	5	74	2	26192437
Pubmed	PECAM/eGFP transgenic mice for monitoring of angiogenesis in health and disease.	PTPRC PECAM1	4.45e-05	5	74	2	30514882
Pubmed	Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase.	PECAM1 CDK1	4.45e-05	5	74	2	29518391
Pubmed	Hlf Expression Marks Early Emergence of Hematopoietic Stem Cell Precursors With Adult Repopulating Potential and Fate.	PTPRC PECAM1	4.45e-05	5	74	2	34589491
Pubmed	Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells.	PTPRC PECAM1	4.45e-05	5	74	2	12068292
Pubmed	Runx1 is required for progression of CD41+ embryonic precursors into HSCs but not prior to this.	PTPRC PECAM1	4.45e-05	5	74	2	25139854
Pubmed	Efficient xenoengraftment in severe immunodeficient NOD/Shi-scid IL2rγnull mice is attributed to a lack of CD11c+B220+CD122+ cells.	PTPRC PRKDC	4.45e-05	5	74	2	23018460
Pubmed	Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication.	FANCD2 BRIP1	4.45e-05	5	74	2	19748364
Pubmed	Ablation of TrkA function in the immune system causes B cell abnormalities.	PTPRC PRKDC	4.45e-05	5	74	2	15459109
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	TNPO1 PDE12 FARSB CDK1 XPO1 HUWE1 EDC4 DHTKD1	4.50e-05	607	74	8	39147351
Pubmed	The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.	TNPO1 CDK1 HUWE1	4.82e-05	33	74	3	26296893
Pubmed	BMPR2 is required for postimplantation uterine function and pregnancy maintenance.	PTPRC PIM1 PECAM1	5.28e-05	34	74	3	23676498
Pubmed	SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.	FANCD2 TNPO1 PRKDC CDK1 XPO1 HUWE1 SLC27A3	5.91e-05	463	74	7	34901782
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	TNPO1 MDN1 ERAL1 PRKDC NUP188 CDK1 XPO1 HUWE1 EDC4 ADAR	6.11e-05	1024	74	10	24711643
Pubmed	Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses.	FANCD2 BRIP1	6.66e-05	6	74	2	24966277
Pubmed	The Role of SCL Isoforms in Embryonic Hematopoiesis.	PTPRC PECAM1	6.66e-05	6	74	2	37047400
Pubmed	The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization.	PTPRC PECAM1	6.66e-05	6	74	2	21355089
Pubmed	Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling.	RAPGEF3 PECAM1	6.66e-05	6	74	2	23886837
Pubmed	Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain.	TNPO1 XPO1	6.66e-05	6	74	2	10202161
Pubmed	Phosphorylation of Crm1 by CDK1-cyclin-B promotes Ran-dependent mitotic spindle assembly.	CDK1 XPO1	6.66e-05	6	74	2	23729730
Pubmed	Phenotype and hematopoietic potential of side population cells throughout embryonic development.	PTPRC PECAM1	6.66e-05	6	74	2	12805065
Pubmed	Ubiquitin ligase ARF-BP1/Mule modulates base excision repair.	UBE2E1 HUWE1	6.66e-05	6	74	2	19713937
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	MDN1 FARSB PRKDC XPO1 HUWE1 EDC4	7.76e-05	332	74	6	32786267
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	DCAF13 NUP188 CDK1 HUWE1 EDC4 ADAR	7.76e-05	332	74	6	25693804
Pubmed	Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.	MDN1 PRKDC CDK1 XPO1 HUWE1 ADAR	7.89e-05	333	74	6	36779763
Pubmed	Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production.	TNPO1 PRKDC XPO1 HUWE1 ADAR	8.03e-05	206	74	5	22174317
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	MARS2 SMG1 PDE12 USP24 TLN2 XPO1 EDC4	9.31e-05	498	74	7	36634849
Pubmed	Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment.	PRKDC SIRPG	9.31e-05	7	74	2	23293079
Pubmed	Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus.	PTPRC PECAM1	9.31e-05	7	74	2	21502490
Pubmed	Coordinated lymphangiogenesis is critical in lymph node development and maturation.	PTPRC PECAM1	9.31e-05	7	74	2	27623309
Pubmed	mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert).	MET PRKDC	9.31e-05	7	74	2	24870234
Pubmed	CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.	FANCD2 XPO1	9.31e-05	7	74	2	20805509
Interaction	TNFSF13B interactions	FANCD2 TNPO1 MDN1 PRKDC NUP188 XPO1	4.99e-06	119	74	6	int:TNFSF13B
Interaction	NPTN interactions	FANCD2 TNPO1 SMG1 MDN1 USP24 XPO1 HUWE1 EDC4	8.13e-06	278	74	8	int:NPTN
Interaction	LPAR4 interactions	FANCD2 ARHGEF40 PRKDC XPO1	9.02e-06	36	74	4	int:LPAR4
Interaction	BIRC3 interactions	FANCD2 DCAF13 PDE12 MDN1 ERAL1 PIM1 FARSB TLN2 PRKDC NUP188 CDK1 XPO1 HUWE1 EDC4 STX16 ADAR	2.15e-05	1334	74	16	int:BIRC3
Interaction	TK1 interactions	FANCD2 FAM20C DCAF13 MAMDC2 HERC3 CDK1 MEI1	3.08e-05	243	74	7	int:TK1
Interaction	LMBR1L interactions	FANCD2 TNPO1 ARHGEF40 PDE12 NISCH USP24 FARSB PRKDC NUP188 XPO1 HUWE1 EDC4 SLC27A3	3.62e-05	946	74	13	int:LMBR1L
Interaction	ITGB3 interactions	MDN1 PECAM1 PRKDC CDK1 XPO1 HUWE1	3.80e-05	170	74	6	int:ITGB3
Interaction	RASSF1 interactions	MET PRKDC XPO1 HUWE1 MERTK	3.85e-05	103	74	5	int:RASSF1
Interaction	BRCA1 interactions	FANCD2 TNPO1 BRIP1 PDE12 MDN1 UBE2E1 FARSB C2CD6 PRKDC CDK1 LRRK1 XPO1 HUWE1 ALDH9A1 PRPF39	4.02e-05	1249	74	15	int:BRCA1
Interaction	FANCG interactions	FANCD2 NECAB2 CYP19A1 CDK1 XPO1	4.03e-05	104	74	5	int:FANCG
Interaction	HSP90AA1 interactions	FANCD2 SMG1 MET FHAD1 DCAF13 ZBTB20 PIM1 MAST1 PRKDC CDK1 LRRK1 XPO1 HUWE1 MERTK TRIM10	4.57e-05	1263	74	15	int:HSP90AA1
Interaction	IGF1R interactions	FANCD2 TNPO1 MET MDN1 TRAPPC5 NISCH PRKDC CDK1 XPO1	5.19e-05	467	74	9	int:IGF1R
Interaction	BIRC5 interactions	FANCD2 USP38 PRKDC CDK1 XPO1	6.26e-05	114	74	5	int:BIRC5
Interaction	STIP1 interactions	FANCD2 TNPO1 FAM20C MDN1 ERAL1 USP24 PRKDC NUP188 CDK1 XPO1 HUWE1 EDC4 ADAR	6.80e-05	1006	74	13	int:STIP1
Interaction	DDX6 interactions	FANCD2 SMG1 DCAF13 RAPGEF3 PIM1 ZBTB43 XPO1 HUWE1 EDC4	9.16e-05	503	74	9	int:DDX6
GeneFamily	Adenosine deaminases acting on RNA	ADAT3 ADAR	1.76e-04	8	46	2	1303
GeneFamily	EF-hand domain containing\|Diacylglycerol kinases	DGKZ DGKH	2.81e-04	10	46	2	1178
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	FANCD2 BRIP1	1.17e-03	20	46	2	548
GeneFamily	Phosphodiesterases	PDE8A PDE11A	1.69e-03	24	46	2	681
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	MET MERTK	4.64e-03	40	46	2	321
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_1000	FANCD2 BRIP1 DCAF13 MDN1 GSPT2 ZBTB43 HERC3 NUP188	1.68e-05	333	72	8	gudmap_dev gonad_e13.5_M_GermCell_Oct_k1_1000
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000	FANCD2 SMG1 BRIP1 DCAF13 MDN1 PDE8A PECAM1 DDX25 HERC3 PRKDC NUP188 HUWE1	1.85e-05	820	72	12	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_k-means-cluster#2_top-relative-expression-ranked_1000	FANCD2 BRIP1 DCAF13 MDN1 FARSB HERC3 NUP188	3.29e-05	266	72	7	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_k2_1000
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_500	FANCD2 BRIP1 DCAF13 MDN1 PECAM1 ZBTB43 DDX25 PRKDC	5.76e-05	396	72	8	gudmap_dev gonad_e13.5_M_GermCell_Oct_500
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_1000	FANCD2 BRIP1 DCAF13 MDN1 GSPT2 PECAM1 ZBTB43 DDX25 HERC3 PRKDC NUP188	8.40e-05	810	72	11	gudmap_dev gonad_e13.5_M_GermCell_Oct_1000
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	SMG1 ZBTB20 PTPRC USP24 DGKH HUWE1	7.19e-07	188	74	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PECAM1 MERTK DHTKD1 TMC3 SLC27A3	9.47e-06	170	74	5	7fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCell	Control-Myeloid-MoAM2,_CCL18\|Myeloid / Condition, Lineage and Cell class	FAM20C ARHGEF40 MAMDC2 MERTK MEI1	1.15e-05	177	74	5	470f54fe2b21c7350ea471e02039461a3808f700
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	SMG1 ZBTB20 PTPRC DGKH HUWE1	1.28e-05	181	74	5	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	BRIP1 PTPRC PRKDC XPO1 HUWE1	1.46e-05	186	74	5	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6\|TCGA-Breast / Sample_Type by Project: Shred V9	ARHGEF40 MEGF6 RAPGEF3 NISCH THSD7B	1.54e-05	188	74	5	c90669b51e1902fe7726555290c91c92a911df83
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_plasma\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PECAM1 LRRK1 MERTK MEI1 TMC3	1.98e-05	198	74	5	567fcf882c8612356946240843525b786f3c8dbe
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PIM1 PECAM1 LRRK1 MERTK MEI1	2.02e-05	199	74	5	1bb02f41f3cc76a28581e38b0ca4c36b930b85b4
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-CARM1P1--L3-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MET ADAMTSL1 DGKH LRRK1 MERTK	2.07e-05	200	74	5	47791c93d03ee17c1ce17e27f075be4fc6f2590e
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial-Proteoglycan-expressing_cell\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	FSIP2 PDE8A LRRK1 MEI1 SLC27A3	2.07e-05	200	74	5	aafe594c88710f8c53d59667cdac5035e08f5511
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Mild / Disease, condition lineage and cell class	MDN1 PIM1 DGKH ADAR SIRPG	2.07e-05	200	74	5	d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-CARM1P1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MET ADAMTSL1 DGKH LRRK1 MERTK	2.07e-05	200	74	5	f75d95376a340d467c4392b872b2a2dbdd184556
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-CARM1P1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MET ADAMTSL1 DGKH LRRK1 MERTK	2.07e-05	200	74	5	fae26560ba3b0b638b6bcf92f05330824b31d21b
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	FSIP2 PDE8A LRRK1 MEI1 SLC27A3	2.07e-05	200	74	5	a6f0f5f644b7262878b0b9d4d90ee407c4124dd9
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sncg-Sncg_Gpr50\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NECAB2 CYP19A1 TRIM10 PDE11A	2.44e-05	101	74	4	6523c314166dcf66c3ed13c02ca4b886b068e5b8
ToppCell	(09)_Ionocytes-(3)_72hpi\|(09)_Ionocytes / shred by cell type and Timepoint	FAM20C PDE8A TRAPPC5 USP24	3.41e-05	110	74	4	fce7d5a0617fc664b657f5bb9abb290e7cc234cb
Computational	Neighborhood of HDAC2	UBE2E1 COQ9 DGKZ PRKDC NUP188 XPO1 EDC4	1.09e-04	280	43	7	MORF_HDAC2
Disease	beta-hydroxybutyric acid measurement	THSD7B MERTK	8.75e-05	6	72	2	EFO_0010465
Disease	Fanconi anemia (implicated_via_orthology)	FANCD2 BRIP1	1.63e-04	8	72	2	DOID:13636 (implicated_via_orthology)
Disease	breast cancer (is_implicated_in)	FANCD2 BRIP1 CYP19A1 CDK1	5.05e-04	150	72	4	DOID:1612 (is_implicated_in)
Disease	Fanconi anemia	FANCD2 BRIP1	5.24e-04	14	72	2	cv:C0015625
Disease	mean reticulocyte volume	TNPO1 BRIP1 PTPRC PIM1 MAST1 TLN2 XPO1 TRIM10	7.25e-04	799	72	8	EFO_0010701
Disease	Bone marrow hypocellularity	FANCD2 BRIP1	8.76e-04	18	72	2	C1855710
Disease	Severe Combined Immunodeficiency	PTPRC PRKDC	1.08e-03	20	72	2	C0085110
Disease	refractive error, age at onset, Myopia	ADAMTSL1 BRIP1 MEI1 PDE11A	1.29e-03	193	72	4	EFO_0004847, HP_0000545, MONDO_0004892
Disease	cervical squamous cell carcinoma (is_marker_for)	BRIP1 ADAR	1.31e-03	22	72	2	DOID:3744 (is_marker_for)
Disease	Hereditary Paraganglioma-Pheochromocytoma Syndrome	MET MERTK	1.44e-03	23	72	2	C1708353
Disease	Adenocarcinoma of large intestine	MET PIM1 PRKDC	1.69e-03	96	72	3	C1319315
Disease	Fanconi Anemia	FANCD2 BRIP1	1.70e-03	25	72	2	C0015625
Disease	Pancytopenia	FANCD2 BRIP1	1.84e-03	26	72	2	C0030312
Disease	Acute monocytic leukemia	FANCD2 BRIP1	1.84e-03	26	72	2	C0023465
Disease	pancreatic cancer (is_marker_for)	MET XPO1 MUC6	1.96e-03	101	72	3	DOID:1793 (is_marker_for)
Disease	Miller Dieker syndrome	FANCD2 BRIP1	2.28e-03	29	72	2	C0265219
Disease	glutamate measurement	BRIP1 PDE8A	2.28e-03	29	72	2	EFO_0010487

Protein segments in the cluster

Peptide	Gene	Start	Entry
HRFQVFRGVLEEQCR	ADAT3	331	Q96EY9
AHRVVAELQAGTCFI	ALDH9A1	431	P49189
IHQEVVRLCRLCQGV	ARHGEF40	676	Q8TER5
GVRFLTCLNRVREHV	C9orf163	106	Q8N9P6
RQCGHVGRTEEVLLT	ADGRG2	6	Q8IZP9
VGRGTFSQRHAIVVC	DHTKD1	596	Q96HY7
CIRTIQAHEGFVRGI	DCAF13	101	Q9NV06
ITIGQAIIFCQTRRN	DDX25	336	Q9UHL0
SFGIQVVSRCRLRHT	EDC4	461	Q6P2E9
SCERQHQIIFEAIRG	MAMDC2	631	Q7Z304
LRTGTVFERCHATVN	MUC6	596	Q6W4X9
HQEFGRKCVVSIRDI	MDN1	1591	Q9NU22
ARISVQVHNATCTVR	MERTK	446	Q12866
GQEGLRQLIFHVTCS	LRRK1	811	Q38SD2
VTQIACGRQHTLAFV	HERC3	296	Q15034
VQVLHGNIFVCRLEV	C2CD6	221	Q53TS8
QIHRVIQSDTICFGR	FSIP2	5041	Q5CZC0
HRQVFCQTRDGITLP	ADAMTSL1	1631	Q8N6G6
CHSGRTFDVQIVIIE	GSPT2	516	Q8IYD1
ADQISGFHIRSVLCV	PDE11A	501	Q9HCR9
QRFGHSRELESVCVV	PDE12	256	Q6L8Q7
VLSFRCQARIISGIH	PECAM1	201	P16284
IRHYVSIIRVCNGNN	PDE8A	316	O60658
VSRKVHTTRCQALGV	ERAL1	141	O75616
IQRTIREAFQGCTVL	ABCC11	1316	Q96J66
REAFQGCTVLVIAHR	ABCC11	1321	Q96J66
HRIAQCRTVKITIFG	DGKH	901	Q86XP1
FVHTCRVGQSEIRSI	HUWE1	906	Q7Z6Z7
NGTHERVVVLFERCV	PRPF39	366	Q86UA1
TLERDVGCTRHQSVQ	MAST1	1381	Q9Y2H9
TQLVSQDQRVCIHFI	MEI1	81	Q5TIA1
TTQQIRKRHCFGTEV	BRIP1	166	Q9BX63
VRCKGSRHEEVIQRQ	FHAD1	1136	B1AJZ9
VNDCHAEIISRRGFI	ADAR	906	P55265
RRFHVKTLQGQCVES	CYP19A1	456	P11511
QHRTVIADQFTVCLR	GBA2	181	Q9HCG7
AVRDCVERNGLHSVV	FAM20C	556	Q8IXL6
ILHFVTQCNTRLTRV	COQ9	146	O75208
GHGERLTQCREVVLT	DGKZ	576	Q13574
QRSAQEIVHCVFQLL	FANCD2	1006	Q9BXW9
HVCAEQELTLVGRRQ	MEGF6	46	O75095
VGRRQPCVQALSHTV	MEGF6	56	O75095
GQVFFRQRVSSECQH	PIM1	251	P11309
AQTFHTRIIRFCSIN	MET	271	P08581
IHNRRVALGITCVQC	SKOR1	116	P84550
LTCNVPHQQVFRASR	TMC3	601	Q7Z5M5
QRCVDVCRVQLVHSG	SMG1	796	Q96Q15
VCRVQLVHSGTRIRQ	SMG1	801	Q96Q15
RSQVICEVAHVTLQG	SIRPG	221	Q9P1W8
HSRITVNTRNIFIEC	FARSB	241	Q9NSD9
QILQGIVFCHSRRVL	CDK1	111	P06493
CVRGHVTERQQIVSG	NEU3	106	Q9UQ49
QLCDVSIVVQGHIFR	ZBTB43	31	O43298
VHSRSQVVGICQVLL	RAPGEF3	146	O95398
IAQKCRRHFVQVQVG	XPO1	591	O14980
LIGVVCAFVTNQRTH	PROM2	166	Q8N271
QHRVTVFQYIGELCR	SLC27A3	366	Q5K4L6
TQEITQLFHRCQRAV	STX16	126	O14662
IHVQGSIRQFAACLV	NISCH	716	Q9Y2I1
HQERTLQCLNAVRTV	NUP188	1426	Q5SRE5
VRQENVTVFGCLTHE	TMEM8B	96	A6NDV4
VSSCVRQTNGFVQRH	MARS2	476	Q96GW9
LVRTIGHFQCVSTQE	USP38	171	Q8NB14
GHFQCVSTQERELRE	USP38	176	Q8NB14
VFRVEVLCSGRRHTV	SNX22	26	Q96L94
HAVACVNQFIISRTQ	TNPO1	201	Q92973
RNCISTVVHQGLIRI	PRKDC	476	P78527
EQRNRGHFCDVTVRI	ZBTB20	96	Q9HC78
QRFDRATCVLAHTGI	TRIM10	346	Q9UDY6
VALHAGICVRQQSVS	USP24	1386	Q9UPU5
QIRTRVQDLGHGCIF	TLN2	1916	Q9Y4G6
VGIQTRRVFCVKSHV	THSD7B	696	Q9C0I4
RTRIYHCNINSQGVI	UBE2E1	116	P51965
QIIFCRSEAAHQGVI	PTPRC	396	P08575
ELRRVFRGHTFIINC	WDR86	306	Q86TI4
LVQHCQSRVFSVAEL	TRAPPC5	36	Q8IUR0
RCLFEAEITQIQSHI	KRT71	266	Q3SY84
VRNCFHITAVRLSDG	NECAB2	316	Q7Z6G3