Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	beta-catenin binding	FOXO3 PTPRU SMAD3	5.57e-04	120	27	3	GO:0008013
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	FOXO3 CTCFL HIVEP2 SMAD3 TP73	8.25e-04	560	27	5	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	FOXO3 CTCFL HIVEP2 SMAD3 TP73	8.65e-04	566	27	5	GO:0001216
GeneOntologyMolecularFunction	transcription coregulator binding	FOXO3 SMAD3 TP73	8.72e-04	140	27	3	GO:0001221
GeneOntologyMolecularFunction	protein kinase binding	FOXO3 RAPGEF2 UTRN SMAD3 TP73 RAB11FIP2	9.23e-04	873	27	6	GO:0019901
GeneOntologyMolecularFunction	chromatin DNA binding	FOXO3 CTCFL SMAD3	1.45e-03	167	27	3	GO:0031490
GeneOntologyMolecularFunction	kinase binding	FOXO3 RAPGEF2 UTRN SMAD3 TP73 RAB11FIP2	1.58e-03	969	27	6	GO:0019900
GeneOntologyMolecularFunction	tau protein binding	DYRK1A CLU	1.76e-03	46	27	2	GO:0048156
GeneOntologyMolecularFunction	transcription corepressor binding	SMAD3 TP73	2.87e-03	59	27	2	GO:0001222
GeneOntologyBiologicalProcess	cellular response to nerve growth factor stimulus	FOXO3 RAPGEF1 RAPGEF2	6.19e-05	59	27	3	GO:1990090
GeneOntologyBiologicalProcess	response to nerve growth factor	FOXO3 RAPGEF1 RAPGEF2	6.84e-05	61	27	3	GO:1990089
GeneOntologyBiologicalProcess	Rap protein signal transduction	RAPGEF1 RAPGEF2	1.49e-04	14	27	2	GO:0032486
GeneOntologyBiologicalProcess	nerve growth factor signaling pathway	RAPGEF1 RAPGEF2	1.49e-04	14	27	2	GO:0038180
Domain	RasGEFN	RAPGEF1 RAPGEF2	3.76e-04	20	27	2	SM00229
Domain	RasGEF_N	RAPGEF1 RAPGEF2	4.16e-04	21	27	2	PF00618
Domain	RASGEF_NTER	RAPGEF1 RAPGEF2	4.57e-04	22	27	2	PS50212
Domain	Ras-like_Gua-exchang_fac_N	RAPGEF1 RAPGEF2	4.57e-04	22	27	2	IPR000651
Domain	RASGEF_CAT	RAPGEF1 RAPGEF2	7.98e-04	29	27	2	PS50009
Domain	Spectrin_repeat	UTRN KRT77	7.98e-04	29	27	2	IPR002017
Domain	RasGEF	RAPGEF1 RAPGEF2	8.54e-04	30	27	2	PF00617
Domain	-	RAPGEF1 RAPGEF2	8.54e-04	30	27	2	1.10.840.10
Domain	Ras_GEF_dom	RAPGEF1 RAPGEF2	8.54e-04	30	27	2	IPR023578
Domain	RASGEF_cat_dom	RAPGEF1 RAPGEF2	8.54e-04	30	27	2	IPR001895
Domain	RasGEF	RAPGEF1 RAPGEF2	8.54e-04	30	27	2	SM00147
Domain	Spectrin/alpha-actinin	UTRN KRT77	9.72e-04	32	27	2	IPR018159
Domain	SPEC	UTRN KRT77	9.72e-04	32	27	2	SM00150
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES	FOXO3 ABCA6 SMAD3	1.50e-05	30	23	3	M27941
Pathway	REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION	FOXO3 SMAD3	2.54e-05	5	23	2	M27825
Pathway	REACTOME_SIGNALING_BY_NODAL	FOXO3 SMAD3	3.80e-05	6	23	2	MM14517
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES	FOXO3 SMAD3	5.32e-05	7	23	2	MM15661
Pathway	PID_MYC_REPRESS_PATHWAY	FOXO3 CLU SMAD3	1.41e-04	63	23	3	M254
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION	FOXO3 ABCA6 SMAD3	1.62e-04	66	23	3	M27938
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES	FOXO3 SMAD3	3.41e-04	17	23	2	M27946
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION	FOXO3 SMAD3	5.77e-04	22	23	2	MM15656
Pathway	REACTOME_SIGNALING_BY_NODAL	FOXO3 SMAD3	6.31e-04	23	23	2	M511
Pathway	WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT	FOXO3 SMAD3 TP73	7.31e-04	110	23	3	M39492
Pathway	KEGG_NEUROTROPHIN_SIGNALING_PATHWAY	FOXO3 RAPGEF1 TP73	1.08e-03	126	23	3	M16763
Pubmed	Generation of Cajal-Retzius neurons in mouse forebrain is regulated by transforming growth factor beta-Fox signaling pathways.	FOXO3 SMAD3 TP73	9.14e-08	12	27	3	18005957
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DYRK1A FOXO3 HIVEP2 RAPGEF2 UTRN KRT77 RAB11FIP2 NCKIPSD	2.00e-07	861	27	8	36931259
Pubmed	Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth.	RAPGEF1 RAPGEF2	5.80e-07	2	27	2	17724123
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	FOXO3 PALS1 RAPGEF2 UTRN RAB11FIP2 NCKIPSD	1.01e-06	446	27	6	24255178
Pubmed	SMAD3 augments FoxO3-induced MuRF-1 promoter activity in a DNA-binding-dependent manner.	FOXO3 SMAD3	1.74e-06	3	27	2	24920680
Pubmed	nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM).	RAPGEF1 RAPGEF2	1.74e-06	3	27	2	10548487
Pubmed	Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1.	RAPGEF1 RAPGEF2	1.74e-06	3	27	2	17826737
Pubmed	FoxO regulates expression of ABCA6, an intracellular ATP-binding-cassette transporter responsive to cholesterol.	FOXO3 ABCA6	1.74e-06	3	27	2	24028821
Pubmed	FOXO3a Protects against Kidney Injury in Type II Diabetic Nephropathy by Promoting Sirt6 Expression and Inhibiting Smad3 Acetylation.	FOXO3 SMAD3	1.74e-06	3	27	2	34122724
Pubmed	Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads.	SMAD3 TP73	3.48e-06	4	27	2	12732139
Pubmed	Direct activation of forkhead box O3 by tumor suppressors p53 and p73 is disrupted during liver regeneration in mice.	FOXO3 TP73	3.48e-06	4	27	2	20564353
Pubmed	Clusterin, a novel modulator of TGF-beta signaling, is involved in Smad2/3 stability.	CLU SMAD3	3.48e-06	4	27	2	18082619
Pubmed	The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons.	FOXO3 SMAD3 TP73	5.41e-06	44	27	3	27224923
Pubmed	TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3.	HIVEP2 SMAD3	5.80e-06	5	27	2	19448624
Pubmed	Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells.	FOXO3 SMAD3	8.69e-06	6	27	2	21532621
Pubmed	Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control.	RAPGEF1 RAPGEF2	1.22e-05	7	27	2	21840392
Pubmed	Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.	FOXO3 SMAD3	3.18e-05	11	27	2	15084259
Pubmed	A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models.	CLU SMAD3	3.18e-05	11	27	2	17168649
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	DYRK1A FOXO3 RAB11FIP2 NCKIPSD	4.34e-05	255	27	4	15324660
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXO3 ZHX3 CTCFL HIVEP2 SMAD3 TP73	5.77e-05	908	27	6	19274049
Pubmed	Three-dimensional regulation of radial glial functions by Lis1-Nde1 and dystrophin glycoprotein complexes.	PALS1 UTRN	9.84e-05	19	27	2	22028625
Pubmed	The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.	PALS1 SMAD3	1.72e-04	25	27	2	21145499
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	DYRK1A ZHX3 RAI2 NCKIPSD	2.41e-04	398	27	4	35016035
Pubmed	The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.	RAPGEF1 UTRN	2.49e-04	30	27	2	30480076
Pubmed	Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.	FOXO3 SMAD3	2.49e-04	30	27	2	28077597
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	FOXO3 MUC16 CTCFL PTPRU	2.95e-04	420	27	4	28065597
Pubmed	DNA Damage Regulates Translation through β-TRCP Targeting of CReP.	HIVEP2 RAPGEF2	3.40e-04	35	27	2	26091241
Pubmed	Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.	PALS1 SMAD3	4.45e-04	40	27	2	30865227
Pubmed	Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators.	CLU TP73	4.90e-04	42	27	2	23863479
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	PALS1 RAPGEF2 TP73	6.53e-04	220	27	3	24550385
Interaction	HIPK2 interactions	DYRK1A FOXO3 SMAD3 TP73	8.47e-06	98	27	4	int:HIPK2
Interaction	PRDM4 interactions	DYRK1A CTCFL SMAD3	4.54e-05	52	27	3	int:PRDM4
Interaction	BTRC interactions	DYRK1A FOXO3 RAPGEF1 HIVEP2 RAPGEF2 CLU SMAD3	5.48e-05	775	27	7	int:BTRC
Interaction	YWHAH interactions	DYRK1A FOXO3 HIVEP2 RAPGEF2 UTRN KRT77 RAB11FIP2 NCKIPSD	6.80e-05	1102	27	8	int:YWHAH
Interaction	RAB11FIP5 interactions	DYRK1A SMAD3 RAB11FIP2 NCKIPSD	1.07e-04	187	27	4	int:RAB11FIP5
Cytoband	Ensembl 112 genes in cytogenetic band chr6q24	HIVEP2 UTRN	9.73e-04	78	27	2	chr6q24
Cytoband	19p13.2	OR7D4 MUC16	8.01e-03	229	27	2	19p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	RAPGEF1 MIGA2	1.56e-02	325	27	2	chr9q34
GeneFamily	PDZ domain containing	PALS1 RAPGEF2	9.84e-03	152	18	2	1220
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZHX3 CTCFL HIVEP2	3.26e-02	718	18	3	28
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	DYRK1A FOXO3 ZHX3 HIVEP2 RAPGEF2 SMAD3	6.59e-06	466	27	6	M13522
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	DYRK1A FOXO3 HIVEP2 RAPGEF2 SMAD3	1.25e-05	300	27	5	M8702
Coexpression	MIKKELSEN_NPC_WITH_LCP_H3K27ME3	RP1 KRT77	3.66e-05	9	27	2	M2017
Coexpression	MIKKELSEN_NPC_WITH_LCP_H3K27ME3	RP1 KRT77	4.57e-05	10	27	2	MM864
Coexpression	GSE2770_IL12_ACT_VS_ACT_CD4_TCELL_48H_DN	DYRK1A RAPGEF1 TTC39B NCKIPSD	4.84e-05	198	27	4	M6033
Coexpression	ZHENG_BOUND_BY_FOXP3	TTC39B HIVEP2 RAPGEF2 UTRN SMAD3	1.39e-04	498	27	5	M1741
Coexpression	ZHENG_BOUND_BY_FOXP3	TTC39B HIVEP2 RAPGEF2 UTRN SMAD3	1.51e-04	507	27	5	MM1030
Coexpression	CHEN_LVAD_SUPPORT_OF_FAILING_HEART_UP	FOXO3 CLU NCKIPSD	1.56e-04	102	27	3	M12300
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	DYRK1A FOXO3 ZHX3 HIVEP2 RAPGEF2 SMAD3	1.96e-04	856	27	6	M4500
Coexpression	GENTILE_UV_HIGH_DOSE_DN	DYRK1A ZHX3 RAPGEF2 SMAD3	2.08e-04	289	27	4	M13630
Coexpression	DAZARD_RESPONSE_TO_UV_SCC_DN	DYRK1A FOXO3 RAPGEF2	2.23e-04	115	27	3	M7484
ToppCell	droplet-Lung-30m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l33\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZHX3 RAPGEF2 RAB11FIP2	7.49e-05	136	27	3	a43b3db1754c619d328a26a2ba6af4756629a723
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TTC39B CTCFL TP73	1.21e-04	160	27	3	1e210e526ea4d84fc58a798a26c0929bcb69fd89
ToppCell	Ciliated_cells-B-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	MUC16 RP1 TP73	1.30e-04	164	27	3	0e9961acbb1d6c0089e6805ba6756736fa4d8bed
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RP1 HIVEP2 TP73	1.43e-04	169	27	3	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	COVID-19-Heart-EC_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RAPGEF1 RAPGEF2 UTRN	1.69e-04	179	27	3	2a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCell	IIH-plasma\|IIH / Condition, Cell_class and T cell subcluster	PTPRU CLU RAI2	1.74e-04	181	27	3	13d1f31bcbac21aea91de74f51eed549ec61003e
ToppCell	IIH-plasma-\|IIH / Condition, Cell_class and T cell subcluster	PTPRU CLU RAI2	1.74e-04	181	27	3	140ac43dc6b89396872f908c14c89278f6d982b2
ToppCell	Ciliated_cells-A-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	MUC16 RP1 TP73	1.83e-04	184	27	3	07c5a9633ccdcd18771e3230d6198a55c400afa6
ToppCell	saliva-Severe-critical_progression_d28-40\|saliva / Compartment, severity and other cell annotations on 10x 3' data (130k)	FOXO3 PALS1 HIVEP2	1.89e-04	186	27	3	0095560ca776b01aa473ad4d6015ed78fc93ff51
ToppCell	Control-Endothelial-Endothelial-Artery\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAPGEF1 RP1 CLU	1.89e-04	186	27	3	2d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTPRU ABCA6 RAI2	1.89e-04	186	27	3	f07e0c0d9c80ac9d8d679950e7d0c812becb85a3
ToppCell	facs-Heart-LA-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRU CLU RAI2	1.92e-04	187	27	3	7b13c3b67d66f3afb410141d5471c9e78a4d8623
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	RAPGEF1 RAPGEF2 UTRN	1.92e-04	187	27	3	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	facs-Heart-LA-24m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRU CLU RAI2	1.92e-04	187	27	3	d9943e65eedab73d141eae524e2411653a751705
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	DYRK1A RAPGEF2 UTRN	1.95e-04	188	27	3	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	renal_medulla_nuclei-Adult_normal_reference\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	FOXO3 ZHX3 UTRN	2.01e-04	190	27	3	f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ToppCell	COVID-19-Heart-EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	RAPGEF1 RAPGEF2 UTRN	2.01e-04	190	27	3	a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCell	BAL-Control-Epithelial-Epithelial\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	MUC16 RP1 CLU	2.04e-04	191	27	3	df8a1a6e78aa0cb941b94cb676bd6891d79f3687
ToppCell	Healthy_Control-Epithelial-Epithelial\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	MUC16 RP1 CLU	2.04e-04	191	27	3	15b9386b26caaa7d15f704c4a18881e1ce918a21
ToppCell	BAL-Control-Epithelial\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	MUC16 RP1 CLU	2.04e-04	191	27	3	9f19098f260d5542aa8ba7eb6f91b44d0db6e0a4
ToppCell	BAL-Control-Epithelial-Epithelial-Ciliated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MUC16 RP1 CLU	2.04e-04	191	27	3	fa9f8b50bfc7911c858bc2f9dcd204873d97ac61
ToppCell	Control-Epithelial\|Control / Disease group,lineage and cell class （2021.01.30）	MUC16 RP1 CLU	2.04e-04	191	27	3	b78547dae8328244a47c83346447bdd787efbcae
ToppCell	Control-Epithelial-Ciliated_cells\|Control / Condition, Lineage and Cell class	MUC16 RP1 TP73	2.04e-04	191	27	3	ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCell	Healthy_Control-Epithelial-Epithelial-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	MUC16 RP1 CLU	2.04e-04	191	27	3	28caedb2e448e0c7f494100d714fa7cdcf150691
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-MUC16+_ciliated\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MUC16 RP1 TP73	2.04e-04	191	27	3	e81cd65dbf0ef1c2ab7088f73ce605d456dd3a7a
ToppCell	BAL-Control-Epithelial-Epithelial-Ciliated\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MUC16 RP1 CLU	2.04e-04	191	27	3	c4b223b33c020a064f576711a3d700eb60a2d737
ToppCell	Healthy_Control-Epithelial\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	MUC16 RP1 CLU	2.04e-04	191	27	3	fdcdadbfc9ccae175abe4de8c7428ac4f6a67fde
ToppCell	BAL-Control-Epithelial-Epithelial\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MUC16 RP1 CLU	2.04e-04	191	27	3	c50d6a1a6209ed4157f7c00fc24d4ecb43790f44
ToppCell	BAL-Control-Epithelial\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MUC16 RP1 CLU	2.04e-04	191	27	3	5129f778a9283bfac4ff322c21c5ca71da4b7174
ToppCell	Control-Epithelial\|Control / Condition, Lineage and Cell class	MUC16 RP1 TP73	2.04e-04	191	27	3	6228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCell	COPD-Epithelial-Goblet\|COPD / Disease state, Lineage and Cell class	MUC16 PTPRU CLU	2.08e-04	192	27	3	93b2ca0a97776d28c7e8f1a0642c4b63a5554aab
ToppCell	LA-14._Fibroblast_III\|LA / Chamber and Cluster_Paper	HIVEP2 ABCA6 SMAD3	2.11e-04	193	27	3	7426c291bac59e539c427bcaae18abc7d397d44e
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FOXO3 RAPGEF1 UTRN	2.11e-04	193	27	3	779276e775cb2492e8dd36436295a536084a6415
ToppCell	LA-14._Fibroblast_III\|World / Chamber and Cluster_Paper	HIVEP2 ABCA6 SMAD3	2.14e-04	194	27	3	803fa83ceada17c38ca9f933b888f7e7b0b90761
ToppCell	LA-02._Fibroblast_II\|LA / Chamber and Cluster_Paper	FOXO3 ABCA6 SMAD3	2.14e-04	194	27	3	234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCell	RV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	FOXO3 ABCA6 SMAD3	2.17e-04	195	27	3	ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCell	COVID-19-Heart-EC_1\|Heart / Disease (COVID-19 only), tissue and cell type	RAPGEF1 RAPGEF2 UTRN	2.17e-04	195	27	3	50a193475db1bb1e05b8590225a553688c372c14
ToppCell	Control-Myeloid-ncMonocyte\|Control / Disease state, Lineage and Cell class	FOXO3 UTRN SMAD3	2.17e-04	195	27	3	fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCell	Control-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	FOXO3 UTRN SMAD3	2.17e-04	195	27	3	b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCell	LPS_IL1RA_TNF\|World / Treatment groups by lineage, cell group, cell type	ABCA6 CLU UTRN	2.24e-04	197	27	3	0a6550dce156fc81f15b1e7830d331ca50d87d06
ToppCell	Control_saline-Epithelial_alveolar-AT_1\|Control_saline / Treatment groups by lineage, cell group, cell type	PTPRU CLU UTRN	2.27e-04	198	27	3	9b161285df7a4e51618f3517cfc5b8221ba55786
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	PTPRU CLU UTRN	2.27e-04	198	27	3	85f424cd9bb3117c9e322031024aabb87696ce47
ToppCell	BAL-Mild-Epithelial-Epithelial\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MUC16 RP1 CLU	2.31e-04	199	27	3	1ee4010d8557564e25e8ee00b914c2dfd9037838
ToppCell	BAL-Mild-Epithelial-Epithelial\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	MUC16 RP1 CLU	2.31e-04	199	27	3	1df69c0cb5f759f6a2152521842506a75bb95cae
ToppCell	Mild-Epithelial\|Mild / Condition, Lineage, Cell class and cell subclass	MUC16 RP1 CLU	2.31e-04	199	27	3	ec5fff80e2a8a94fbaf1fdcc6d45c8d7c6252e18
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	DYRK1A RAPGEF2 UTRN	2.31e-04	199	27	3	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Mild-Epithelial-Epithelial-\|Mild / Condition, Lineage, Cell class and cell subclass	MUC16 RP1 CLU	2.31e-04	199	27	3	81115bbd2c10bfdd38376d2075f03a59c31870d2
ToppCell	Mild-Epithelial-Epithelial\|Mild / Condition, Lineage, Cell class and cell subclass	MUC16 RP1 CLU	2.31e-04	199	27	3	91308b255783ad4029e5575028c18d7550832c51
ToppCell	BAL-Mild-Epithelial\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MUC16 RP1 CLU	2.31e-04	199	27	3	74087b4b5e567310fc4ac58fb267ff651a180680
ToppCell	Mild_COVID-19-Epithelial\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	MUC16 RP1 CLU	2.31e-04	199	27	3	72689bda7476930887ae007682fcab27f956f050
ToppCell	BAL-Mild-Epithelial\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	MUC16 RP1 CLU	2.31e-04	199	27	3	00b5ce099c50a5e1786ce2b3a06ee0931a8205a4
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Mesenchymal\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	SMAD3 TP73 NCKIPSD	2.34e-04	200	27	3	e5b7d9622b96bb20c81ac76b4e60e8b44fa9cca1
Disease	HMG CoA reductase inhibitor use measurement	ZHX3 RP1 ABCA6 SMAD3	2.55e-05	189	27	4	EFO_0009932
Disease	waist-hip ratio, metabolic syndrome	DYRK1A HFM1	2.89e-05	9	27	2	EFO_0000195, EFO_0004343
Disease	coronary artery disease	TTC39B ZHX3 RP1 HIVEP2 PTPRU RAPGEF2 SMAD3	7.60e-05	1194	27	7	EFO_0001645
Disease	low density lipoprotein cholesterol measurement, alcohol consumption measurement	ZHX3 RP1 ABCA6	1.01e-04	99	27	3	EFO_0004611, EFO_0007878
Disease	low density lipoprotein cholesterol measurement, alcohol drinking	ZHX3 RP1 ABCA6	1.10e-04	102	27	3	EFO_0004329, EFO_0004611
Disease	alkaline phosphatase measurement	ZHX3 HFM1 CTCFL RP1 ABCA6 UTRN	2.60e-04	1015	27	6	EFO_0004533
Disease	anti-basement membrane glomerulonephritis (biomarker_via_orthology)	RAPGEF1 CLU	3.45e-04	30	27	2	DOID:4780 (biomarker_via_orthology)
Disease	prostate cancer (is_marker_for)	FOXO3 SMAD3 TP73	3.86e-04	156	27	3	DOID:10283 (is_marker_for)
Disease	non-high density lipoprotein cholesterol measurement	ZHX3 HFM1 RP1 ABCA6 SMAD3	4.22e-04	713	27	5	EFO_0005689
Disease	linoleic acid measurement	TTC39B ZHX3 ABCA6	6.45e-04	186	27	3	EFO_0006807
Disease	omega-6 polyunsaturated fatty acid measurement	TTC39B ZHX3 ABCA6	7.62e-04	197	27	3	EFO_0005680
Disease	cholesteryl esters to total lipids in small VLDL percentage	TTC39B ABCA6	9.23e-04	49	27	2	EFO_0022256
Disease	IGF-1 measurement	FOXO3 ZHX3 HFM1 SMAD3	9.59e-04	488	27	4	EFO_0004627
Disease	Tourette syndrome	MUC16 PTPRU	9.61e-04	50	27	2	EFO_0004895
Disease	low density lipoprotein cholesterol measurement, physical activity	RP1 ABCA6	1.67e-03	66	27	2	EFO_0003940, EFO_0004611
Disease	intellectual disability (implicated_via_orthology)	DYRK1A HIVEP2	2.15e-03	75	27	2	DOID:1059 (implicated_via_orthology)
Disease	longevity	DYRK1A FOXO3 RP1	2.17e-03	284	27	3	EFO_0004300
Disease	daytime rest measurement	ZHX3 HIVEP2 MIGA2	2.42e-03	295	27	3	EFO_0007828
Disease	lipoprotein measurement, phospholipid measurement	TTC39B ABCA6	2.75e-03	85	27	2	EFO_0004639, EFO_0004732
Disease	physical activity	TTC39B CTCFL	2.94e-03	88	27	2	EFO_0003940
Disease	lipid measurement, lipoprotein measurement	TTC39B ABCA6	3.07e-03	90	27	2	EFO_0004529, EFO_0004732
Disease	Degenerative polyarthritis	CLU SMAD3	3.28e-03	93	27	2	C0029408
Disease	Osteoarthrosis Deformans	CLU SMAD3	3.28e-03	93	27	2	C0086743
Disease	Inhalant adrenergic use measurement	MUC16 SMAD3	3.49e-03	96	27	2	EFO_0009941
Disease	myocardial infarction	ZHX3 SMAD3 NCKIPSD	3.92e-03	350	27	3	EFO_0000612
Disease	waist-hip ratio	FOXO3 ZHX3 CTCFL SMAD3 TP73	4.62e-03	1226	27	5	EFO_0004343
Disease	factor VIII measurement, coronary artery disease	RP1 SMAD3	4.79e-03	113	27	2	EFO_0001645, EFO_0004630
Disease	antihyperlipidemic drug use measurement	RP1 ABCA6	4.96e-03	115	27	2	EFO_0803367
Disease	cutaneous melanoma	RAPGEF1 RAB11FIP2	5.47e-03	121	27	2	EFO_0000389

Protein segments in the cluster

Peptide	Gene	Start	Entry
SSRMSSFNRHMKTHT	CTCFL	266	Q8NI51
AHSSFSEMQTAVSDM	ABCA6	816	Q8N139
STQDSMEVGHSHHSM	DYRK1A	641	Q13627
MEVGHSHHSMTSLSS	DYRK1A	646	Q13627
SHEAPAMMDSHISSS	RAI2	391	Q9Y5P3
AMMDSHISSSDAATE	RAI2	396	Q9Y5P3
DTEMQNDSFHSDSHM	IWS1	341	Q96ST2
HTEAMHASMHTNTAV	MUC16	5706	Q8WXI7
SSSHSMDTDKMASVF	OR5B2	261	Q96R09
HSGSSHSVASMMAVN	MIGA2	131	Q7L4E1
HMMSAVDRSFTDQST	PTPRU	801	Q92729
EMSNSFVSSHEMSDI	HFM1	1321	A2PYH4
MTTSHMNGHVTEESD	PALS1	1	Q8N3R9
HSSQSSSTASVMYAM	OR7D4	266	Q8NG98
MSSSHSAQSMVSGSH	TP73	466	O15350
FMQTVSSDDSESHMS	FAM216A	231	Q8WUB2
SEYHMFTHSCSKMSS	RP1	496	P56715
SDSLSHSDVMMTQSD	FOXO3	476	O43524
THEAFMMELTAHQSS	UTRN	351	P46939
ASSVAVMTSSTSDHH	NCKIPSD	111	Q9NZQ3
HMLDVMQDHFSRASS	CLU	171	P10909
SSSHMDQIMFSDHST	RAPGEF2	1291	Q9Y4G8
NHMSDNRSMSVDLSH	UHRF1BP1L	926	A0JNW5
SISSHSDMATSSLHF	TTC39B	91	Q5VTQ0
MDTDSQRSHLSSFTM	RAPGEF1	1	Q13905
SEDGETSDHQMNHSM	SMAD3	186	P84022
HSMSDLSGSHMSSEK	RAB11FIP2	226	Q7L804
HSMSSISTDHQFSDA	HIVEP2	1886	P31629
SHDMTQFVGHMNSEH	ZHX3	86	Q9H4I2
MSHQFSSQSAFSSMS	KRT77	1	Q7Z794