Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	negative regulation of leukocyte differentiation	LILRB2 RC3H1 TJP2 ZFPM1 ZBTB7B	5.10e-05	151	55	5	GO:1902106
GeneOntologyBiologicalProcess	negative regulation of hemopoiesis	LILRB2 RC3H1 TJP2 ZFPM1 ZBTB7B	6.51e-05	159	55	5	GO:1903707
GeneOntologyBiologicalProcess	multicellular organismal-level homeostasis	CRACD SH2B3 LILRB2 RC3H1 ERRFI1 DEF8 TJP2 ZFPM1 ZBTB7B ALK NOVA1	8.08e-05	1043	55	11	GO:0048871
GeneOntologyBiologicalProcess	negative regulation of epidermal growth factor receptor signaling pathway	SNX6 ERRFI1 SNX5	8.42e-05	32	55	3	GO:0042059
GeneOntologyBiologicalProcess	regulation of T-helper 17 cell differentiation	RC3H1 BRD4 ZBTB7B	9.25e-05	33	55	3	GO:2000319
GeneOntologyBiologicalProcess	T-helper cell differentiation	RC3H1 BRD4 ZFPM1 ZBTB7B	1.06e-04	92	55	4	GO:0042093
GeneOntologyBiologicalProcess	CD4-positive, alpha-beta T cell differentiation involved in immune response	RC3H1 BRD4 ZFPM1 ZBTB7B	1.15e-04	94	55	4	GO:0002294
GeneOntologyBiologicalProcess	alpha-beta T cell differentiation involved in immune response	RC3H1 BRD4 ZFPM1 ZBTB7B	1.20e-04	95	55	4	GO:0002293
GeneOntologyBiologicalProcess	negative regulation of ERBB signaling pathway	SNX6 ERRFI1 SNX5	1.31e-04	37	55	3	GO:1901185
GeneOntologyBiologicalProcess	alpha-beta T cell activation involved in immune response	RC3H1 BRD4 ZFPM1 ZBTB7B	1.36e-04	98	55	4	GO:0002287
GeneOntologyBiologicalProcess	regulation of leukocyte differentiation	SH2B3 LILRB2 RC3H1 BRD4 TJP2 ZFPM1 ZBTB7B	1.38e-04	429	55	7	GO:1902105
GeneOntologyBiologicalProcess	T cell differentiation involved in immune response	RC3H1 BRD4 ZFPM1 ZBTB7B	1.64e-04	103	55	4	GO:0002292
GeneOntologyBiologicalProcess	retrograde transport, endosome to Golgi	SNX6 SNX32 DCTN1 SNX5	2.05e-04	109	55	4	GO:0042147
GeneOntologyBiologicalProcess	T-helper 17 cell differentiation	RC3H1 BRD4 ZBTB7B	2.68e-04	47	55	3	GO:0072539
GeneOntologyBiologicalProcess	regulation of T-helper 17 type immune response	RC3H1 BRD4 ZBTB7B	2.68e-04	47	55	3	GO:2000316
GeneOntologyBiologicalProcess	CD4-positive, alpha-beta T cell differentiation	RC3H1 BRD4 ZFPM1 ZBTB7B	2.86e-04	119	55	4	GO:0043367
GeneOntologyBiologicalProcess	regulation of T cell differentiation	SH2B3 LILRB2 RC3H1 BRD4 ZBTB7B	3.37e-04	226	55	5	GO:0045580
GeneOntologyBiologicalProcess	regulation of T-helper cell differentiation	RC3H1 BRD4 ZBTB7B	4.74e-04	57	55	3	GO:0045622
GeneOntologyBiologicalProcess	T cell differentiation	SH2B3 LILRB2 RC3H1 BRD4 ZFPM1 ZBTB7B	5.23e-04	382	55	6	GO:0030217
GeneOntologyBiologicalProcess	regulation of hemopoiesis	SH2B3 LILRB2 RC3H1 BRD4 TJP2 ZFPM1 ZBTB7B	5.54e-04	540	55	7	GO:1903706
GeneOntologyBiologicalProcess	negative regulation of T-helper 17 cell differentiation	RC3H1 ZBTB7B	6.22e-04	14	55	2	GO:2000320
GeneOntologyBiologicalProcess	T cell activation involved in immune response	RC3H1 BRD4 ZFPM1 ZBTB7B	6.53e-04	148	55	4	GO:0002286
GeneOntologyBiologicalProcess	T-helper 17 type immune response	RC3H1 BRD4 ZBTB7B	6.66e-04	64	55	3	GO:0072538
GeneOntologyBiologicalProcess	cytosolic transport	SNX6 SNX32 DCTN1 SNX5	6.87e-04	150	55	4	GO:0016482
GeneOntologyBiologicalProcess	regulation of lymphocyte differentiation	SH2B3 LILRB2 RC3H1 BRD4 ZBTB7B	7.06e-04	266	55	5	GO:0045619
GeneOntologyBiologicalProcess	mitral valve morphogenesis	ZFPM1 AXIN2	7.17e-04	15	55	2	GO:0003183
GeneOntologyBiologicalProcess	negative regulation of epidermal growth factor-activated receptor activity	SNX6 ERRFI1	7.17e-04	15	55	2	GO:0007175
GeneOntologyBiologicalProcess	negative regulation of T-helper 17 type immune response	RC3H1 ZBTB7B	7.17e-04	15	55	2	GO:2000317
GeneOntologyBiologicalProcess	CD4-positive, alpha-beta T cell activation	RC3H1 BRD4 ZFPM1 ZBTB7B	7.40e-04	153	55	4	GO:0035710
GeneOntologyBiologicalProcess	alpha-beta T cell differentiation	RC3H1 BRD4 ZFPM1 ZBTB7B	8.15e-04	157	55	4	GO:0046632
GeneOntologyBiologicalProcess	mitral valve development	ZFPM1 AXIN2	8.18e-04	16	55	2	GO:0003174
GeneOntologyBiologicalProcess	stress-activated protein kinase signaling cascade	ERRFI1 MAP2K7 SEMA4C	8.30e-04	69	55	3	GO:0031098
GeneOntologyCellularComponent	retromer complex	SNX6 DCTN1 SNX5	2.47e-05	21	57	3	GO:0030904
GeneOntologyCellularComponent	retromer, tubulation complex	SNX6 SNX5	4.37e-05	4	57	2	GO:0030905
GeneOntologyCellularComponent	tubular endosome	SNX6 SNX5	7.27e-05	5	57	2	GO:0097422
Domain	SNX5/SNX6/SNX32	SNX6 SNX32 SNX5	2.42e-08	3	55	3	IPR014637
Domain	Vps5	SNX6 SNX32 SNX5	2.41e-07	5	55	3	PF09325
Domain	Vps5_C	SNX6 SNX32 SNX5	2.41e-07	5	55	3	IPR015404
Domain	DUF4592	CRACD CRACDL	2.55e-05	3	55	2	IPR028030
Domain	DUF4592	CRACD CRACDL	2.55e-05	3	55	2	PF15262
Domain	PX	SNX6 SNX32 SNX5	4.04e-04	49	55	3	PF00787
Domain	PX	SNX6 SNX32 SNX5	4.29e-04	50	55	3	PS50195
Domain	-	SNX6 SNX32 SNX5	4.55e-04	51	55	3	3.30.1520.10
Domain	Phox	SNX6 SNX32 SNX5	4.82e-04	52	55	3	IPR001683
Domain	-	RGS20 AXIN2	1.89e-03	22	55	2	1.10.196.10
Domain	RGS_subdom1	RGS20 AXIN2	1.89e-03	22	55	2	IPR024066
Domain	RING	RNF223 KMT2D RC3H1 MEX3D DEF8	2.01e-03	305	55	5	SM00184
Domain	Znf_RING	RNF223 KMT2D RC3H1 MEX3D DEF8	2.68e-03	326	55	5	IPR001841
Domain	RGS	RGS20 AXIN2	4.76e-03	35	55	2	PF00615
Domain	RGS	RGS20 AXIN2	4.76e-03	35	55	2	SM00315
Domain	RGS	RGS20 AXIN2	5.03e-03	36	55	2	PS50132
Domain	KH_1	MEX3D NOVA1	5.59e-03	38	55	2	PF00013
Domain	-	MEX3D NOVA1	5.88e-03	39	55	2	3.30.1370.10
Domain	RGS	RGS20 AXIN2	5.88e-03	39	55	2	IPR016137
Domain	KH	MEX3D NOVA1	6.18e-03	40	55	2	SM00322
Domain	KH_dom	MEX3D NOVA1	6.18e-03	40	55	2	IPR004087
Domain	KH_TYPE_1	MEX3D NOVA1	6.80e-03	42	55	2	PS50084
Domain	KH_dom_type_1	MEX3D NOVA1	7.44e-03	44	55	2	IPR004088
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	RNF223 LIME1 KMT2D RAPGEF6 SH2B3 BRD4 MEX3D ANKRD34A MAP3K11 NLGN2 ZFPM1 BCL9 ALKBH6 DCTN1 GGT7	1.95e-10	1105	57	15	35748872
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	RAPGEF6 SNX6 NPEPPS TJP2 BUD13 NLGN2 SNX5 SEMA4C ANKS1A	1.09e-08	378	57	9	34315543
Pubmed	Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila.	SNX6 SNX32 SNX5	8.32e-08	6	57	3	26172538
Pubmed	The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network.	SNX6 DCTN1 SNX5	3.48e-07	9	57	3	19619496
Pubmed	Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: a MLK-3-MKK7-dependent mechanism.	MAP3K11 MAP2K7	2.64e-06	2	57	2	18222647
Pubmed	Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection.	SNX6 SNX5	2.64e-06	2	57	2	26118995
Pubmed	Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins.	SNX6 SNX5	2.64e-06	2	57	2	31576058
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	KMT2D RAPGEF6 BRD4 TJP2 BUD13 ZFPM1 BCL9 FAM53C ANKS1A	4.43e-06	774	57	9	15302935
Pubmed	A splice form of polycystin-2, lacking exon 7, does not interact with polycystin-1.	RAPGEF6 PKD2	7.91e-06	3	57	2	16192288
Pubmed	PtdIns(4)P regulates retromer-motor interaction to facilitate dynein-cargo dissociation at the trans-Golgi network.	SNX6 DCTN1	7.91e-06	3	57	2	23524952
Pubmed	A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer.	SNX6 SNX5	7.91e-06	3	57	2	17148574
Pubmed	Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin.	PKD2 AXIN2	1.58e-05	4	57	2	19939939
Pubmed	HBx activates FasL and mediates HepG2 cell apoptosis through MLK3-MKK7-JNKs signal module.	MAP3K11 MAP2K7	1.58e-05	4	57	2	22509080
Pubmed	The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate.	MAP3K11 MAP2K7	1.58e-05	4	57	2	10187804
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	ERRFI1 TJP2 ARHGEF17 ANKS1A	2.44e-05	102	57	4	15778465
Pubmed	Metabolic stress signaling mediated by mixed-lineage kinases.	MAP3K11 MAP2K7	2.63e-05	5	57	2	17679097
Pubmed	A unique set of SH3-SH3 interactions controls IB1 homodimerization.	MAP3K11 MAP2K7	2.63e-05	5	57	2	16456539
Pubmed	Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling.	MAP3K11 MAP2K7	2.63e-05	5	57	2	15001580
Pubmed	The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport.	SNX6 DCTN1	2.63e-05	5	57	2	19935774
Pubmed	Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling.	BCL9 AXIN2	5.51e-05	7	57	2	30366904
Pubmed	Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.	ERRFI1 ALK	5.51e-05	7	57	2	19815557
Pubmed	LZTR1 is a regulator of RAS ubiquitination and signaling.	RAPGEF6 SNX6 SNX5 SEMA4C	5.77e-05	127	57	4	30442766
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	KMT2D RAPGEF6 GTF3C2 BRD4 DCTN1 RCOR2	6.29e-05	418	57	6	34709266
Pubmed	Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.	SH2B3 ERRFI1 ANKS1A	6.85e-05	48	57	3	24262325
Pubmed	The JIP group of mitogen-activated protein kinase scaffold proteins.	MAP3K11 MAP2K7	7.34e-05	8	57	2	10490659
Pubmed	Retromer: Structure, function, and roles in mammalian disease.	SNX6 SNX5	7.34e-05	8	57	2	26220253
Pubmed	Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK.	MAP3K11 MAP2K7	9.43e-05	9	57	2	26947074
Pubmed	WNT signaling suppresses oligodendrogenesis via Ngn2-dependent direct inhibition of Olig2 expression.	OLIG1 AXIN2	1.18e-04	10	57	2	33187539
Pubmed	Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3.	MAP3K11 MAP2K7	1.18e-04	10	57	2	10629060
Pubmed	A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress.	MAP3K11 MAP2K7	1.18e-04	10	57	2	28930674
Pubmed	Tulp3 Regulates Renal Cystogenesis by Trafficking of Cystoproteins to Cilia.	PKD2 MAP2K7	1.18e-04	10	57	2	30799239
Pubmed	Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis.	CRACD CRACDL	1.18e-04	10	57	2	31234534
Pubmed	JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.	RAPGEF6 TJP2	1.18e-04	10	57	2	23885123
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	KMT2D GTF3C2 BRD4 CRYBG1 TASOR2 ANKS1A	1.18e-04	469	57	6	27634302
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	KMT2D BRD4 ALK	2.20e-04	71	57	3	28319113
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KMT2D RAPGEF6 GTF3C2 BRD4 TJP2 DCTN1	2.76e-04	549	57	6	38280479
Pubmed	Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis.	PKD2 AXIN2	3.12e-04	16	57	2	29056552
Pubmed	A large family of endosome-localized proteins related to sorting nexin 1.	SNX6 SNX5	3.53e-04	17	57	2	11485546
Pubmed	Stage-specific regulation of oligodendrocyte development by Wnt/β-catenin signaling.	OLIG1 AXIN2	3.53e-04	17	57	2	24948802
Pubmed	Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).	MAP3K11 MAP2K7	4.92e-04	20	57	2	12897243
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	RAPGEF6 BRD4 TJP2 ARHGEF17 MAP2K7 FAM53C ANKS1A	5.01e-04	861	57	7	36931259
Pubmed	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.	RGS20 GCC1 ZBTB7B MTUS2 TASOR2	5.14e-04	402	57	5	24722188
Pubmed	Wnt3a links left-right determination with segmentation and anteroposterior axis elongation.	PKD2 AXIN2	5.43e-04	21	57	2	16291790
Pubmed	Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways.	MAP3K11 MAP2K7	5.97e-04	22	57	2	15767678
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CRACD GTF3C2 CRACDL CDC42EP5 CRYBG1 BUD13 ZBTB7B SEMA4C CYBA	6.90e-04	1497	57	9	31527615
Pubmed	The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.	AXIN2 SEMA4C	7.73e-04	25	57	2	35874829
Pubmed	Wnt signaling determines ventral spinal cord cell fates in a time-dependent manner.	OLIG1 AXIN2	7.73e-04	25	57	2	18927156
Pubmed	Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway.	RAPGEF6 DCTN1	8.36e-04	26	57	2	28720576
Pubmed	Angiopoietin-like 2 is essential to aortic valve development in mice.	LILRB2 AXIN2	8.36e-04	26	57	2	36414704
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	KMT2D BRD4 BCL9 ATXN1L	9.88e-04	268	57	4	33640491
Pubmed	Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.	ATXN1L RCOR2 TASOR2	1.02e-03	120	57	3	21697133
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SNX6 DEF8 MAP3K11 ALKBH6 DCTN1 FAM53C MTUS2 SNX5	1.12e-03	1285	57	8	35914814
Pubmed	An inter-species protein-protein interaction network across vast evolutionary distance.	RGS20 GCC1 ZBTB7B MTUS2 TASOR2	1.17e-03	483	57	5	27107014
Pubmed	Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis.	PKD2 AXIN2	1.27e-03	32	57	2	25715394
Pubmed	The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.	BRD4 AXIN2	1.35e-03	33	57	2	19336002
Pubmed	Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate.	AXIN2 SEMA4C	1.35e-03	33	57	2	18480165
Pubmed	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.	RCOR2 AXIN2	1.43e-03	34	57	2	30894540
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	RAPGEF6 MEX3D ERRFI1 TJP2 CRYBG1 MAP2K7 FAM53C	1.49e-03	1038	57	7	26673895
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	KMT2D GTF3C2 SNX6	1.56e-03	139	57	3	25476789
Pubmed	Characterization of the piRNA complex from rat testes.	CRACD NPEPPS RC3H1	1.59e-03	140	57	3	16778019
Interaction	SNX27 interactions	RAPGEF6 SNX6 NPEPPS TJP2 BUD13 NLGN2 DCTN1 SNX5 SEMA4C ANKS1A	1.21e-06	509	56	10	int:SNX27
Interaction	TOP3B interactions	RNF223 LIME1 KMT2D RAPGEF6 SH2B3 BRD4 MEX3D ANKRD34A MAP3K11 NLGN2 ZFPM1 BCL9 ALKBH6 DCTN1 AXIN2 GGT7	1.50e-06	1470	56	16	int:TOP3B
Interaction	FAM221A interactions	SNX6 SNX5 ANKS1A	2.61e-05	21	56	3	int:FAM221A
Interaction	STAC2 interactions	SNX6 ATXN1L SNX5	3.46e-05	23	56	3	int:STAC2
Interaction	MAPK8IP3 interactions	MAP3K11 DCTN1 MAP2K7 ALK	4.28e-05	70	56	4	int:MAPK8IP3
Interaction	UPK2 interactions	LIME1 CLEC17A NLGN2 SEMA4C GGT7	4.63e-05	142	56	5	int:UPK2
Cytoband	Ensembl 112 genes in cytogenetic band chr16q24	DEF8 ZFPM1 CYBA	6.62e-04	136	57	3	chr16q24
Cytoband	Ensembl 112 genes in cytogenetic band chr11q13	SNX32 MAP3K11 ARHGEF17 RCOR2	2.47e-03	454	57	4	chr11q13
Cytoband	11q13.1	SNX32 RCOR2	2.82e-03	63	57	2	11q13.1
Cytoband	2q11.2	CRACDL SEMA4C	3.66e-03	72	57	2	2q11.2
GeneFamily	Sorting nexins\|PX-BAR domain containing	SNX6 SNX32 SNX5	1.71e-06	12	37	3	1290
GeneFamily	Sorting nexins\|PX-BAR domain containing	SNX6 SNX32 SNX5	2.78e-05	29	37	3	754
ToppCell	droplet-Spleen-SPLEEN-1m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRACD SLC2A6 CDC42EP5 OLIG1 SEMA4C	3.25e-06	178	57	5	742ee0cb8cb585a5e34bd5b20aebe9bb99756e0c
Disease	Polycystic kidney disease, type 2	BRD4 PKD2	7.38e-05	7	56	2	C2751306
Disease	triacylglycerol 51:2 measurement	GTF3C2 BUD13	9.83e-05	8	56	2	EFO_0021483
Disease	Polycystic Kidney, Type 1 Autosomal Dominant Disease	BRD4 PKD2	9.83e-05	8	56	2	C0887850
Disease	Polycystic Kidney, Autosomal Dominant	BRD4 PKD2	1.26e-04	9	56	2	C0085413
Disease	intracranial aneurysm (is_implicated_in)	KMT2D PKD2	2.31e-04	12	56	2	DOID:10941 (is_implicated_in)
Disease	colon carcinoma (is_marker_for)	KMT2D AXIN2	2.72e-04	13	56	2	DOID:1520 (is_marker_for)
Disease	sleep duration, triglyceride measurement	GTF3C2 BUD13 ALK	1.03e-03	104	56	3	EFO_0004530, EFO_0005271
Disease	sexual dimorphism measurement	C17orf67 RAPGEF6 SNX32 NPEPPS MAP3K11 BUD13 ANKS1A GGT7	1.09e-03	1106	56	8	EFO_0021796
Disease	triacylglycerol 56:5 measurement	BUD13 ALK	1.12e-03	26	56	2	EFO_0010432
Disease	lung small cell carcinoma (is_implicated_in)	KMT2D AXIN2	1.30e-03	28	56	2	DOID:5409 (is_implicated_in)
Disease	keratinocyte carcinoma	DEF8 TSPYL5 ZBTB7B	1.48e-03	118	56	3	EFO_0010176
Disease	uridine measurement	PKD2 ALK	1.69e-03	32	56	2	EFO_0010546
Disease	Abnormality of refraction	C17orf67 TJP2 GCC1 ZBTB7B DCTN1 AXIN2	1.70e-03	673	56	6	HP_0000539
Disease	colorectal carcinoma (is_marker_for)	SH2B3 AXIN2	2.26e-03	37	56	2	DOID:0080199 (is_marker_for)
Disease	age at onset, Myopia	C17orf67 DEF8 TJP2	2.93e-03	150	56	3	EFO_0004847, HP_0000545
Disease	fibrinogen measurement, coronary artery disease	RAPGEF6 SH2B3 ANKS1A	3.16e-03	154	56	3	EFO_0001645, EFO_0004623
Disease	Mammary Carcinoma, Human	KMT2D SNX32 ANKRD34A MAP2K7 ALK	3.17e-03	525	56	5	C4704874
Disease	Mammary Neoplasms, Human	KMT2D SNX32 ANKRD34A MAP2K7 ALK	3.17e-03	525	56	5	C1257931
Disease	fibromuscular dysplasia	TJP2 MTUS2	3.18e-03	44	56	2	EFO_1000938
Disease	Mammary Neoplasms	KMT2D SNX32 ANKRD34A MAP2K7 ALK	3.22e-03	527	56	5	C1458155
Disease	triacylglycerol 54:4 measurement	BUD13 MTUS2	3.47e-03	46	56	2	EFO_0010422
Disease	Breast Carcinoma	KMT2D SNX32 ANKRD34A MAP2K7 ALK	3.52e-03	538	56	5	C0678222
Disease	lung adenocarcinoma (is_implicated_in)	MAP2K7 AXIN2	3.93e-03	49	56	2	DOID:3910 (is_implicated_in)
Disease	Diffuse Large B-Cell Lymphoma	KMT2D ALK	4.93e-03	55	56	2	C0079744
Disease	Ischemic stroke, fibrinogen measurement	RAPGEF6 SH2B3	4.93e-03	55	56	2	EFO_0004623, HP_0002140
Disease	triacylglycerol 52:2 measurement	GTF3C2 BUD13	4.93e-03	55	56	2	EFO_0010414
Disease	fibrinogen measurement, factor VII measurement	RAPGEF6 SH2B3	5.46e-03	58	56	2	EFO_0004619, EFO_0004623

Protein segments in the cluster

Peptide	Gene	Start	Entry
RRPEDDDPTEQPRPP	ALKBH6	141	Q3KRA9
PDPSPRKDRHDTPDP	BUD13	136	Q9BRD0
EYDAERPPSKPPPVE	DCTN1	911	Q14203
RSEPFSPSLRPEPPK	BRD4	1121	O60885
PDPSSSFREDAPRPP	AXIN2	11	Q9Y2T1
DRPYEEPPQKPPRFS	ANKS1A	831	Q92625
RDVFEFPLPKPPDDP	ANKRD34A	211	Q69YU3
GFPPKPDPQAREAER	MTUS2	981	Q5JR59
EERKVISPPPFAPSP	RC3H1	766	Q5TC82
EPDPADPKREPLPSR	RCOR2	216	Q8IZ40
KPPEAARPADEPTPA	ARHGEF17	1041	Q96PE2
DPPEDAPKRPKEAAP	HDGFL1	151	Q5TGJ6
ARATFPDKEPTPPPI	ATXN1L	446	P0C7T5
PPRPPAEARKKPSEE	CYBA	156	P13498
SFPRLPEDEPAPAAP	GGT7	26	Q9UJ14
PERIDPPDPTKPDYD	MAP2K7	286	O14733
PEDAPAARRPKAPPG	ZFPM1	606	Q8IX07
PRPPPEPDDAAAALR	MEX3D	46	Q86XN8
RKATEPPPSQEREPP	LILRB2	571	Q8N423
PEKRPFERLPADVSP	NPEPPSL1	46	A6NEC2
PKAAREKPEAPAEPP	OLIG1	66	Q8TAK6
FPEKPPPSPGDRARV	SLC2A6	16	Q9UGQ3
APERPKAERAEAPPA	CRACDL	536	Q6NV74
VEDDRPARGPPPPKS	GCC1	116	Q96CN9
KPAAPPRPLDRESPG	BCL9	266	O00512
SDRRPPSPPGPEERK	CRACD	1011	Q6ZU35
RRQDRPSKPGFPDEP	C17orf67	36	Q0P5P2
RPEAAAAKPDAEPRP	CDC42EP5	111	Q6NZY7
PELPPGEPEFRCPER	DEF8	106	Q6ZN54
RAPAKESPPKRVPDP	CRYBG1	126	Q9Y4K1
PFSQVLRPEPPDPEK	FAM53C	91	Q9NYF3
PEPEPEPGPRAYDRF	NLGN2	651	Q8NFZ4
PPASEAPDRPSKPER	PRRT3	326	Q5FWE3
PEKRPFERLPADVSP	NPEPPS	46	P55786
GNPPRPSLEPEEPKR	MAP3K11	611	Q16584
DPPDSRKRPLEAPPE	NOVA1	21	P51513
PVAEPEEERPKPSRP	TNNT1	31	P13805
KKDDRYREPPPTPPG	RAPGEF6	1496	Q8TEU7
PLRPPHPVAKPREED	RGS20	146	O76081
APFREAPPAEELPAP	PPP1R3G	16	B7ZBB8
TSPPFRPCPEPDEKL	SEMA4C	716	Q9C0C4
SDEDRPPKVPPREPL	ERRFI1	311	Q9UJM3
KREEERSPAAPPPLP	ALK	1431	Q9UM73
APPRPPRAAKETEKP	CLEC17A	96	Q6ZS10
KPAEPPAPARDPAPR	RNF223	166	E7ERA6
EDPPAPQPKAAPRTF	TJP2	481	Q9UDY2
RRRKDDAPPHYPPPS	ZBTB7B	461	O15156
PKARSSEELAPPRPP	SH2B3	116	Q9UQQ2
PPAPTKPDFDGPREK	SNX5	91	Q9Y5X3
QPGDAKRPPAPRAPD	PKD2	11	Q13563
IPPAPPRPDFDASRE	SNX6	91	Q9UNH7
DRPESQSPKRPPEDF	GTF3C2	161	Q8WUA4
PDDPVVKPKDRPPSA	TASOR2	711	Q5VWN6
PPAPPRPDFEASREK	SNX32	86	Q86XE0
PEDPRSPAKPAAPED	PRRT1B	21	A0A1B0GWB2
RPAPDDAPRDPDPSQ	TSPYL5	26	Q86VY4
PEERPPPAADASEPR	KMT2D	3096	O14686
PESARPKPRARPPEE	KMT2D	4956	O14686
PKRRDPGPTTDPLDP	LIME1	206	Q9H400