Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	translation regulator activity, nucleic acid binding	PAIP2 LARP1 EIF3CL EIF4E1B EIF4G2 EIF3B	2.00e-05	112	99	6	GO:0090079
GeneOntologyMolecularFunction	translation initiation factor activity	EIF3CL EIF4E1B EIF4G2 EIF3B	1.19e-04	51	99	4	GO:0003743
GeneOntologyBiologicalProcess	positive regulation of cilium assembly	HAP1 DZIP1 ASAP1 HTT	2.43e-05	35	100	4	GO:0045724
GeneOntologyBiologicalProcess	ribonucleoprotein complex biogenesis	USP36 REXO4 RIOK3 DICER1 EIF3CL SHQ1 NGRN EIF3B LAS1L NOP2 TGS1	4.04e-05	515	100	11	GO:0022613
GeneOntologyBiologicalProcess	translational initiation	PAIP2 LARP1 EIF3CL EIF4E1B EIF4G2 EIF3B	4.47e-05	132	100	6	GO:0006413
GeneOntologyBiologicalProcess	mitotic intra-S DNA damage checkpoint signaling	XPC MDC1 NEK11	7.16e-05	17	100	3	GO:0031573
GeneOntologyBiologicalProcess	axo-dendritic transport	ANK3 HAP1 KIF1B BSN HTT	1.15e-04	98	100	5	GO:0008088
GeneOntologyBiologicalProcess	rRNA processing	USP36 REXO4 RIOK3 DICER1 SHQ1 LAS1L NOP2	1.30e-04	230	100	7	GO:0006364
GeneOntologyBiologicalProcess	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	HAP1 HTT	1.39e-04	4	100	2	GO:0031587
GeneOntologyBiologicalProcess	retrograde axonal transport	HAP1 KIF1B BSN	2.08e-04	24	100	3	GO:0008090
GeneOntologyBiologicalProcess	ribosome biogenesis	USP36 REXO4 RIOK3 DICER1 SHQ1 NGRN LAS1L NOP2	2.31e-04	336	100	8	GO:0042254
GeneOntologyBiologicalProcess	protein-RNA complex organization	TFIP11 DICER1 EIF3CL SHQ1 EIF3B NOP2 TGS1	2.39e-04	254	100	7	GO:0071826
GeneOntologyCellularComponent	neuron projection cytoplasm	HAP1 KIF1B CHRNA2 BSN HTT	1.69e-04	110	98	5	GO:0120111
GeneOntologyCellularComponent	cytoplasmic region	HAP1 KIF1B TTLL8 CHRNA2 BSN DNAH6 UNC13A HTT	2.93e-04	360	98	8	GO:0099568
Domain	ARM-type_fold	IPO8 UBR4 CUL9 ARMC2 ARMCX1 MROH1 EIF4G2 PPP6R2 HTT	7.93e-05	339	99	9	IPR016024
Domain	ARM-like	IPO8 CUL9 ARMC2 ARMCX1 MROH1 PPP6R2 HTT	5.86e-04	270	99	7	IPR011989
Domain	-	IPO8 CUL9 ARMC2 ARMCX1 MROH1 HTT	1.18e-03	222	99	6	1.25.10.10
Domain	Ank_3	ANK3 ANKRD27	1.22e-03	10	99	2	PF13606
Domain	ARM-rpt_dom	ARMCX1 ARMCX6	1.48e-03	11	99	2	IPR006911
Domain	Arm_2	ARMCX1 ARMCX6	1.48e-03	11	99	2	PF04826
Domain	-	ANKRD65 ANK3 ANKS4B ANKRD27 ASAP1 NFKBIL1	2.07e-03	248	99	6	1.25.40.20
Domain	ANK	ANKRD65 ANK3 ANKS4B ANKRD27 ASAP1 NFKBIL1	2.19e-03	251	99	6	SM00248
Domain	ANK_REPEAT	ANKRD65 ANK3 ANKS4B ANKRD27 ASAP1 NFKBIL1	2.28e-03	253	99	6	PS50088
Domain	Ankyrin_rpt-contain_dom	ANKRD65 ANK3 ANKS4B ANKRD27 ASAP1 NFKBIL1	2.33e-03	254	99	6	IPR020683
Domain	ANK_REP_REGION	ANKRD65 ANK3 ANKS4B ANKRD27 ASAP1 NFKBIL1	2.33e-03	254	99	6	PS50297
Domain	Ankyrin_rpt	ANKRD65 ANK3 ANKS4B ANKRD27 ASAP1 NFKBIL1	2.72e-03	262	99	6	IPR002110
Domain	CS_dom	SHQ1 ITGB1BP2	3.18e-03	16	99	2	IPR007052
Domain	CS	SHQ1 ITGB1BP2	3.18e-03	16	99	2	PS51203
Domain	NAP	NAP1L5 NAP1L1	3.59e-03	17	99	2	PF00956
Domain	NAP_family	NAP1L5 NAP1L1	3.59e-03	17	99	2	IPR002164
Domain	Ank_2	ANKRD65 ANK3 ANKS4B ANKRD27 ASAP1	5.75e-03	215	99	5	PF12796
Domain	-	FOXR1 LARP1 CUL9 EIF3CL DDRGK1	6.09e-03	218	99	5	1.10.10.10
Domain	G_patch	TFIP11 GPATCH3	6.54e-03	23	99	2	SM00443
Domain	G_patch_dom	TFIP11 GPATCH3	6.54e-03	23	99	2	IPR000467
Domain	G_PATCH	TFIP11 GPATCH3	6.54e-03	23	99	2	PS50174
Domain	G-patch	TFIP11 GPATCH3	6.54e-03	23	99	2	PF01585
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	AMER1 DCAF8 TRIM26 PAIP2 POLR2B RBM26 NAP1L1 RIOK3 GIGYF1 SHQ1 SETD2 CDC123 GYS1 HPS6 EIF4G2 LAS1L PPP6R2 TGS1	1.31e-09	1038	102	18	26673895
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	USP36 DLG5 REXO4 TRIM26 POLR2B DHX38 RBM26 NAP1L1 PRPF38B TFIP11 XPC DICER1 SETD2 BRD8 MDC1 EIF4G2 DDRGK1 MACF1 EIF3B LAS1L	1.20e-08	1497	102	20	31527615
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ZC3H13 KIF1B LARP1 PRPF38B TFIP11 XPC EIF3CL SETD2 BRD8 MDC1 EIF4G2 EIF3B KLHDC4 NOP2	6.35e-08	774	102	14	15302935
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	USP36 REXO4 POLR2B UBR4 DHX38 NAP1L1 RIOK3 TFIP11 XPC ARMCX1 ANKRD27 ASAP1 MDC1 EIF4G2 MACF1 EIF3B LAS1L NOP2	7.61e-08	1353	102	18	29467282
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	USP36 AMER1 ANK3 ZC3H13 UBR4 PRPF38B GHR MDC1 MACF1 DNAH6	1.17e-07	361	102	10	26167880
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	REXO4 ZC3H13 UBR4 DHX38 NAP1L1 LARP1 CUL9 DICER1 MDC1 MACF1 LAS1L NOP2	5.04e-07	653	102	12	22586326
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TICRR AMER1 TRH ANK3 TRIM26 ZC3H13 POLR2B DHX38 TFIP11 ASAP1 BRD8 EIF4G2 MACF1 SZRD1 TGS1	6.41e-07	1084	102	15	11544199
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	POLR2B UBR4 DHX38 RBM26 TFIP11 MDC1 GREB1 LAS1L NOP2	7.75e-07	341	102	9	32971831
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DLG5 DCAF8 IPO8 ANK3 ZC3H13 POLR2B UBR4 TFIP11 DZIP1 DICER1 CDC123 EIF4G2 DDRGK1 MACF1 LAS1L PPP6R2 NOP2	1.49e-06	1487	102	17	33957083
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	USP36 REXO4 ZC3H13 DHX38 LARP1 TFIP11 MDC1 EIF4G2 EIF3B LAS1L NOP2	1.72e-06	605	102	11	28977666
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	TRIM26 UBR4 LARP1 CUL9 SETD2 BRD8 MACF1 LAS1L	1.92e-06	282	102	8	23667531
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	AMER1 DCAF8 UBR4 NAP1L1 LARP1 CUL9 GIGYF1 DICER1 LAS1L PPP6R2 NOP2	2.90e-06	639	102	11	23443559
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	DCAF8 POLR2B UBR4 DHX38 PRPF38B DICER1 SHQ1 BRD8	3.03e-06	300	102	8	28561026
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	USP36 DHX38 RBM26 NAP1L1 LARP1 PRPF38B TFIP11 SETD2 EIF4G2 DDRGK1 MACF1 PPP6R2 NOP2	3.59e-06	934	102	13	33916271
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	USP36 REXO4 IPO8 POLR2B UBR4 DHX38 RBM26 NAP1L1 LARP1 DICER1 EIF3CL MDC1 EIF4G2 EIF3B BSN NOP2	3.96e-06	1425	102	16	30948266
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	ANK3 KIF1B NAP1L1 LARP1 BCAN ASAP1 EIF3CL ERMN EIF4G2 MACF1 BSN TNNT2 PPP6R2 DNAH6 UNC13A CACNA2D3	4.18e-06	1431	102	16	37142655
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	REXO4 ZC3H13 POLR2B DHX38 RBM26 NAP1L1 LARP1 NGRN EIF4G2 MACF1 LAS1L NOP2	4.50e-06	807	102	12	22681889
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	VIL1 POLR2B KIF1B NAP1L5 UBR4 DHX38 LARP1 RIOK3 PRPF38B GYS1 NFKBIL1 EIF4G2 DDRGK1 RASSF8 LAS1L	5.11e-06	1284	102	15	17353931
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	ANK3 POLR2B RBM26 NAP1L1 LARP1 TFIP11 SETD2 BRD8 MDC1 HTT	5.14e-06	549	102	10	38280479
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	ANK3 PAIP2 UBR4 APOBR FAM186B ASAP1 MDC1 NFKBIL1 BSN	5.16e-06	430	102	9	35044719
Pubmed	Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.	TRIM26 TRIM41 DICER1	5.29e-06	12	102	3	33373584
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	USP36 TICRR ZC3H13 POLR2B DHX38 TFIP11 XPC SETD2 BRD8 MDC1 NFKBIL1 EIF4G2 LAS1L NOP2 TET3	5.61e-06	1294	102	15	30804502
Pubmed	A human HAP1 homologue. Cloning, expression, and interaction with huntingtin.	HAP1 HTT	8.52e-06	2	102	2	9668110
Pubmed	Autoinhibitory structure of the WW domain of HYPB/SETD2 regulates its interaction with the proline-rich region of huntingtin.	SETD2 HTT	8.52e-06	2	102	2	24412394
Pubmed	USP36 SUMOylates Las1L and Promotes Its Function in Pre-Ribosomal RNA ITS2 Processing.	USP36 LAS1L	8.52e-06	2	102	2	39356143
Pubmed	Association of HAP1 isoforms with a unique cytoplasmic structure.	HAP1 HTT	8.52e-06	2	102	2	9798945
Pubmed	The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.	HAP1 HTT	8.52e-06	2	102	2	24453320
Pubmed	A huntingtin-associated protein enriched in brain with implications for pathology.	HAP1 HTT	8.52e-06	2	102	2	7477378
Pubmed	Identification of the full-length huntingtin- interacting protein p231HBP/HYPB as a DNA-binding factor.	SETD2 HTT	8.52e-06	2	102	2	11461154
Pubmed	Huntingtin is associated with cytomatrix proteins at the presynaptic terminal.	BSN HTT	8.52e-06	2	102	2	25461618
Pubmed	HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice.	HAP1 HTT	8.52e-06	2	102	2	9599014
Pubmed	pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking.	HAP1 HTT	8.52e-06	2	102	2	20515468
Pubmed	Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease.	HAP1 HTT	8.52e-06	2	102	2	18192679
Pubmed	Huntingtin-associated protein 1 (Hap1) mutant mice bypassing the early postnatal lethality are neuroanatomically normal and fertile but display growth retardation.	HAP1 HTT	8.52e-06	2	102	2	15496430
Pubmed	Human huntingtin-associated protein (HAP-1) gene: genomic organisation and an intragenic polymorphism.	HAP1 HTT	8.52e-06	2	102	2	10974549
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	USP36 REXO4 RBM26 NAP1L1 LARP1 PRPF38B TFIP11 DICER1 EIF3CL NGRN NOP2	9.32e-06	723	102	11	34133714
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	DLG5 TRIM26 KIF1B DHX38 CUL9 RIOK3 SETD2 MACF1 BSN PPP6R2	9.35e-06	588	102	10	38580884
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	REXO4 PAIP2 ZC3H13 TFIP11 ARMC2 FAM186B ANKRD27 FBXL5 BRD8 RGL2 PDZRN4	1.31e-05	750	102	11	11230166
Pubmed	Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension.	TRH GHR GYS1	1.33e-05	16	102	3	17137217
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	KIF1B NAP1L1 RIOK3 DZIP1 ASAP1 ITGB1BP2 EIF4G2 MACF1 TGS1	1.63e-05	497	102	9	23414517
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	ZC3H13 RBM26 NAP1L1 LARP1 GIGYF1 EIF3CL BRD8 LAS1L NOP2	1.80e-05	503	102	9	16964243
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	USP36 REXO4 ZC3H13 RBM26 LARP1 TFIP11 SETD2 BRD8 MDC1 EIF4G2 LAS1L NOP2	2.38e-05	954	102	12	36373674
Pubmed	Interaction of huntingtin-associated protein with dynactin P150Glued.	HAP1 HTT	2.55e-05	3	102	2	9454836
Pubmed	Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis.	SETD2 HTT	2.55e-05	3	102	2	10958656
Pubmed	Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior.	HAP1 HTT	2.55e-05	3	102	2	11971876
Pubmed	Loss of Hap1 selectively promotes striatal degeneration in Huntington disease mice.	HAP1 HTT	2.55e-05	3	102	2	32747555
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	ZC3H13 POLR2B UBR4 DHX38 NAP1L1 LARP1 PRPF38B TFIP11 ANKRD27 EIF3CL GYS1 EIF3B LAS1L NOP2	3.11e-05	1318	102	14	30463901
Pubmed	Large-scale analysis of the human ubiquitin-related proteome.	DLG5 REXO4 TRIM26 UBR4 NAP1L1 RIOK3 LAS1L	3.98e-05	313	102	7	16196087
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	REXO4 ZC3H13 DHX38 NAP1L1 LARP1 TFIP11 XPC MDC1 EIF3B LAS1L NOP2	3.99e-05	847	102	11	35850772
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	ZC3H13 POLR2B RBM26 NAP1L1 LARP1 EIF3CL EIF4G2 DDRGK1 EIF3B NOP2	4.18e-05	701	102	10	30196744
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	POLR2B DHX38 LARP1 DICER1 SETD2 MDC1 LAS1L NOP2	4.79e-05	440	102	8	34244565
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	IPO8 KIF1B UBR4 DHX38 GYS1 EIF3B RASSF8 LAS1L PPP6R2	4.95e-05	573	102	9	28330616
Pubmed	Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.	HAP1 HTT	5.09e-05	4	102	2	21985783
Pubmed	Polyglutamine expansion of huntingtin impairs its nuclear export.	HAP1 HTT	5.09e-05	4	102	2	15654337
Pubmed	Proline-rich transcript in brain protein induces stress granule formation.	EIF4G2 EIF3B	5.09e-05	4	102	2	17984221
Pubmed	HAP1 can sequester a subset of TBP in cytoplasmic inclusions via specific interaction with the conserved TBP(CORE).	HAP1 HTT	5.09e-05	4	102	2	17868456
Pubmed	TRIM26 promotes non-small cell lung cancer survival by inducing PBX1 degradation.	TRIM26 UBR4	5.09e-05	4	102	2	37324936
Pubmed	Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2.	HAP1 HTT	5.09e-05	4	102	2	12881483
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	AMER1 TRIM41 KIF1B LARP1 GIGYF1 VIPAS39 RASSF8 PPP6R2	5.26e-05	446	102	8	24255178
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	UBR4 NAP1L1 GYS1 MDC1 HPS6 EIF4G2 LAS1L	5.76e-05	332	102	7	32786267
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DLG5 REXO4 ZC3H13 POLR2B PRPF38B TFIP11 XPC SETD2 GYS1 MACF1 EIF3B UNC13A	7.98e-05	1082	102	12	38697112
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	DLG5 REXO4 TRIM26 ZC3H13 POLR2B DHX38 NAP1L1 LARP1 EIF3CL MDC1 EIF3B LAS1L NOP2	8.00e-05	1257	102	13	36526897
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	POLR2B NAP1L1 XPC BRD8 MDC1	8.30e-05	150	102	5	28242625
Pubmed	Poly(A) tail length regulates PABPC1 expression to tune translation in the heart.	DICER1 TNNT2	8.47e-05	5	102	2	28653618
Pubmed	A molecular network for the transport of the TI-VAMP/VAMP7 vesicles from cell center to periphery.	ANKRD27 MACF1	8.47e-05	5	102	2	22705394
Pubmed	Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules.	HAP1 HTT	8.47e-05	5	102	2	15242649
Pubmed	Axon initial segment-associated microglia.	ANK3 BCAN	8.47e-05	5	102	2	25653382
Pubmed	UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.	TRIM26 ZC3H13 NAP1L5 NAP1L1 MACF1	9.69e-05	155	102	5	34921745
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	ZC3H13 RBM26 NAP1L1 PRPF38B TFIP11 XPC	1.00e-04	251	102	6	31076518
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	TRIM26 NAP1L1 LARP1 TFIP11 DICER1 LAS1L	1.00e-04	251	102	6	28077445
Pubmed	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.	TRIM26 POLR2B UBR4 NAP1L1 LARP1 GYS1	1.05e-04	253	102	6	29911972
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	USP36 DCAF8 POLR2B BTBD18 CUL9 XPC GIGYF1 DICER1 SETD2 BRD8 NFKBIL1 MACF1	1.07e-04	1116	102	12	31753913
Pubmed	Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development.	TNNT2 TET3	1.27e-04	6	102	2	39262804
Pubmed	A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1.	BSN UNC13A	1.27e-04	6	102	2	19812333
Pubmed	The Calmodulin Binding Region of the Synaptic Vesicle Protein Mover Is Required for Homomeric Interaction and Presynaptic Targeting.	BSN UNC13A	1.27e-04	6	102	2	31787876
Pubmed	Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued.	HAP1 HTT	1.27e-04	6	102	2	18922795
Pubmed	Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release.	BSN UNC13A	1.27e-04	6	102	2	14734538
Pubmed	H3K36 histone methyltransferase Setd2 is required for murine embryonic stem cell differentiation toward endoderm.	VIL1 SETD2	1.27e-04	6	102	2	25242323
Pubmed	Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation.	EIF4E1B TET3	1.27e-04	6	102	2	37257918
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	ANK3 UBR4 PRPF38B ASAP1 EIF3CL VIPAS39 EIF4G2 MACF1 EIF3B BSN PPP6R2 UNC13A	1.29e-04	1139	102	12	36417873
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	POLR2B UBR4 DHX38 RBM26 PRPF38B FAM186B DICER1 FBXL5 SETD2 BRD8 LAS1L NOP2 HTT	1.37e-04	1327	102	13	32694731
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	DCAF8 ANK3 POLR2B UBR4 RBM26 NAP1L1 LARP1 EIF3CL LRRIQ1 GYS1 MACF1 EIF3B	1.40e-04	1149	102	12	35446349
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	AMER1 IPO8 TRIM26 TRIM41 POLR2B NAP1L1 LARP1 DICER1 GYS1 EIF4G2 EIF3B PPP6R2 NOP2	1.45e-04	1335	102	13	29229926
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	USP36 RBM26 TFIP11 EIF3CL MDC1 LAS1L	1.53e-04	271	102	6	32433965
Pubmed	Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.	POLR2B UBR4 LAS1L	1.63e-04	36	102	3	35379950
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USP36 DLG5 LARP1 DZIP1 DICER1 ANKRD27 MDC1 BSN	1.71e-04	529	102	8	14621295
Pubmed	Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation.	EIF4G2 EIF3B	1.77e-04	7	102	2	11331597
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	VIL1 DLG5 REXO4 RBM26 NAP1L1 LARP1 PRPF38B TFIP11 XPC DICER1 NGRN LAS1L NOP2	1.89e-04	1371	102	13	36244648
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	REXO4 DHX38 RBM26 TFIP11 MDC1 NOP2	1.93e-04	283	102	6	30585729
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	POLR2B UBR4 DHX38 RBM26 NAP1L1 PRPF38B SETD2 BRD8 MDC1 EIF4G2 EIF3B	1.95e-04	1014	102	11	32416067
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	DCAF8 IPO8 UBR4 RBM26 NAP1L1 PRPF38B GIGYF1 EIF4G2 RASSF8	1.99e-04	689	102	9	36543142
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	DLG5 AMER1 IPO8 POLR2B KIF1B NAP1L1 ASAP1 EIF4G2 RASSF8 PPP6R2	2.09e-04	853	102	10	28718761
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DLG5 AMER1 KIF1B LARP1 GIGYF1 DZIP1 ANKRD27 MACF1 RASSF8 RGL2	2.25e-04	861	102	10	36931259
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	DLG5 ZC3H13 SETD2 EIF3B DNAH6	2.33e-04	187	102	5	26460568
Pubmed	Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.	HAP1 HTT	2.36e-04	8	102	2	30994454
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	POLR2B UBR4 DHX38 RBM26 NAP1L1 LARP1 TFIP11 MDC1 EIF4G2 DDRGK1 MACF1 EIF3B NOP2	2.56e-04	1415	102	13	28515276
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	TRIM26 MDC1 LAS1L NOP2	2.75e-04	106	102	4	19394292
Pubmed	Functional proteomic analysis of human nucleolus.	USP36 REXO4 LAS1L NOP2	2.75e-04	106	102	4	12429849
Pubmed	Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.	LARP1 MDC1 EIF4G2	2.78e-04	43	102	3	34672947
Pubmed	Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project.	NUGGC ANK3	3.03e-04	9	102	2	20877300
Interaction	SRPK2 interactions	USP36 REXO4 AMER1 ANK3 ZC3H13 TRIM41 UBR4 RBM26 PRPF38B TFIP11 NPM2 GHR SETD2 LRRN4CL MDC1 DDRGK1 MACF1 LAS1L NOP2 DNAH6	3.62e-10	717	101	20	int:SRPK2
Interaction	DDX23 interactions	USP36 REXO4 ZC3H13 DHX38 RBM26 TFIP11 XPC SETD2 CDC123 DDRGK1 LAS1L NOP2	5.08e-06	480	101	12	int:DDX23
Interaction	EIF4E interactions	IPO8 LARP1 DICER1 EIF4E1B CDC123 EIF4G2 DDRGK1 EIF3B	1.55e-05	221	101	8	int:EIF4E
Interaction	RPS4X interactions	USP36 UBR4 NAP1L1 LARP1 RIOK3 EIF3CL LRRC46 CDC123 DDRGK1 EIF3B NOP2 HTT	1.66e-05	540	101	12	int:RPS4X
Interaction	USP7 interactions	USP36 AMER1 MAGEH1 TFIP11 XPC DICER1 IFNLR1 NPM2 LRRN4CL CDC123 MDC1 ARMCX6 DDRGK1 MACF1 KLHL34 LAS1L BSN NOP2 SPDYE4	2.48e-05	1313	101	19	int:USP7
Interaction	DHX40 interactions	USP36 ZC3H13 DHX38 TFIP11 SETD2 BRD8 LAS1L NOP2	3.65e-05	249	101	8	int:DHX40
Interaction	CPA6 interactions	AMER1 DCAF8 DICER1	5.32e-05	15	101	3	int:CPA6
Interaction	PNKD interactions	IPO8 TFIP11 DICER1 CDC123 GREB1 PPP6R2	5.37e-05	132	101	6	int:PNKD
Interaction	PSENEN interactions	USP36 ZC3H13 DHX38 RBM26 PRPF38B	5.42e-05	81	101	5	int:PSENEN
Interaction	NUP43 interactions	USP36 REXO4 ZC3H13 RBM26 LARP1 XPC SETD2 BRD8 MDC1 EIF4G2 LAS1L PPP6R2	6.85e-05	625	101	12	int:NUP43
Interaction	EIF3A interactions	ZC3H13 LARP1 PRPF38B TFIP11 GIGYF1 EIF3CL EIF4G2 EIF3B HTT	7.42e-05	355	101	9	int:EIF3A
Interaction	SRP14 interactions	USP36 REXO4 TRIM41 CDC123 ITGB1BP2 DDRGK1 EIF3B PPP6R2 SZRD1	9.36e-05	366	101	9	int:SRP14
Interaction	RPS2 interactions	USP36 TRIM26 NAP1L5 UBR4 LARP1 RIOK3 DICER1 EIF3CL CDC123 DDRGK1 EIF3B NOP2	1.10e-04	657	101	12	int:RPS2
Interaction	DHX8 interactions	USP36 ZC3H13 DHX38 RBM26 TFIP11 SETD2 DDRGK1 NOP2	1.11e-04	292	101	8	int:DHX8
Interaction	LINC02910 interactions	USP36 ZC3H13 RBM26 PRPF38B TFIP11	1.16e-04	95	101	5	int:LINC02910
Interaction	ZNHIT2 interactions	DCAF8 POLR2B UBR4 DHX38 SHQ1	1.22e-04	96	101	5	int:ZNHIT2
Interaction	GNL2 interactions	USP36 REXO4 ZC3H13 DHX38 RBM26 PRPF38B DICER1 EIF4G2 DDRGK1	1.40e-04	386	101	9	int:GNL2
Interaction	NAP1L5 interactions	HAP1 NAP1L5 MAGEH1 NAP1L1	1.44e-04	53	101	4	int:NAP1L5
Interaction	RPL31 interactions	USP36 REXO4 DCAF8 ZC3H13 NAP1L1 LARP1 NGRN DDRGK1 MACF1 EIF3B LAS1L NOP2	1.52e-04	680	101	12	int:RPL31
Interaction	RPL36AL interactions	USP36 REXO4 TRIM41 NAP1L1 LARP1 DICER1 DDRGK1 NOP2	1.64e-04	309	101	8	int:RPL36AL
Interaction	ANKRD28 interactions	ANK3 TRIM41 CDC123 DDRGK1 RASSF8 PPP6R2 TGS1	1.82e-04	235	101	7	int:ANKRD28
Interaction	SUMO2 interactions	USP36 TRIM26 UBR4 NAP1L1 GYS1 MDC1 HPS6 EIF4G2 LAS1L NOP2 HTT	1.84e-04	591	101	11	int:SUMO2
Interaction	DDX41 interactions	USP36 TRIM26 TRIM41 TFIP11 CDC123 DDRGK1	1.90e-04	166	101	6	int:DDX41
Interaction	DDB1 interactions	USP36 DCAF8 ZC3H13 POLR2B DHX38 TFIP11 XPC SETD2 CDC123 DDRGK1 TET3 HTT	1.90e-04	697	101	12	int:DDB1
Interaction	ZNF7 interactions	REXO4 IPO8 NOP2	2.01e-04	23	101	3	int:ZNF7
Interaction	MAGEH1 interactions	TRIM41 NAP1L5 MAGEH1	2.01e-04	23	101	3	int:MAGEH1
Interaction	LUC7L interactions	USP36 RBM26 LARP1 PRPF38B SETD2 NFKBIL1 DDRGK1	2.18e-04	242	101	7	int:LUC7L
Interaction	UTP15 interactions	USP36 NFKBIL1 DDRGK1 KLHL34 NOP2	2.31e-04	110	101	5	int:UTP15
Interaction	MOV10 interactions	REXO4 PAIP2 KIF1B UBR4 DHX38 LARP1 RIOK3 TFIP11 GIGYF1 DICER1 CDC123 DDRGK1 MACF1 KLHDC4 NOP2 UNC13A SZRD1	2.32e-04	1297	101	17	int:MOV10
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	ARMC2 ARMCX1 ARMCX6	4.72e-04	43	64	3	409
Disease	third ventricle volume measurement	ANK3 HPS6	1.05e-03	15	95	2	EFO_0010335
Disease	facial height measurement	USP36 LARP1 DMRT2 KLHDC4	1.17e-03	142	95	4	EFO_0007856
Disease	synophrys measurement	LRRIQ1 DMRT2 HTT	1.39e-03	68	95	3	EFO_0007906
Disease	glucose measurement	GIGYF1 ARMC2 IFNLR1 CDC123 BSN CACNA2D3	1.46e-03	380	95	6	EFO_0004468
Disease	Endometrioma	TRH DICER1 BRD8 GREB1	1.85e-03	161	95	4	C0269102
Disease	Endometriosis	TRH DICER1 BRD8 GREB1	1.85e-03	161	95	4	C0014175
Disease	Huntington's disease (is_implicated_in)	HAP1 HTT	2.48e-03	23	95	2	DOID:12858 (is_implicated_in)
Disease	frailty measurement	ANK3 HTT	2.48e-03	23	95	2	EFO_0009885
Disease	smoking status measurement, chronic obstructive pulmonary disease	TRIM26 ARMC2 CDC123	2.91e-03	88	95	3	EFO_0000341, EFO_0006527
Disease	Uterine leiomyoma	ARMC2 GREB1 SPDYE4	3.20e-03	91	95	3	HP_0000131

Protein segments in the cluster

Peptide	Gene	Start	Entry
RWDQDEEELEEDLED	UNC13A	316	Q9UPW8
DVWLEEEQEEEEATG	DISP3	11	Q9P2K9
ELDSNVDDWEEETIE	EIF3B	786	P55884
WRETEDPEAEELEES	BRD8	901	Q9H0E9
QEEDAEIEVDEVFWN	ARMC2	256	Q8NEN0
EEREVVVEEEDRWAC	CHRNA2	411	Q15822
EVKEEEEDDDLEYLW	AMER1	396	Q5JTC6
EEEAAALDEWIEVTE	FAM186B	121	Q8IYM0
DYEEEDEEEESLMWR	DICER1	1416	Q9UPY3
QRVAWAEADENEEEA	DDRGK1	81	Q96HY6
QAASDEEEVEEERWQ	EFCC1	391	Q9HA90
RDDSEKLEEEGEEEW	ARMCX6	31	Q7L4S7
DDDQELDEEEPDIWF	ARMCX6	46	Q7L4S7
NDVEIEEEEFWENEL	RASSF8	216	Q8NHQ8
EEEEFWENELQIEQE	RASSF8	221	Q8NHQ8
QDDDEEEEDNESRSW	RBM26	991	Q5T8P6
DEGWLEDERNEFLEE	PDZRN4	491	Q6ZMN7
EEFNRQIEEELWEEE	PAIP2	41	Q9BPZ3
ECEWKPDEEDEISEE	NAP1L1	131	P55209
WTEEDLEDAEDTVSA	ANKRD27	691	Q96NW4
EEEEEEEEVEDEALW	BCAN	466	Q96GW7
WSDEESDYEIDDRDV	LARP1	626	Q6PKG0
LEEEEEEEEWELTQN	KLHL34	321	Q8N239
QDFEEEEADETETAW	LRRN4CL	26	Q8ND94
MEDTQAIDWDVEEEE	MDC1	1	Q14676
AIDWDVEEEEETEQS	MDC1	6	Q14676
DWDSDDDAEVEAILN	MAGEH1	196	Q9H213
ENWRSLREEQEEEEE	GIGYF1	196	O75420
SDWEPEERELQEVES	NGRN	41	Q9NPE2
EEEVADEEASQEWHA	HDGFL1	226	Q5TGJ6
WESSPEEEEEARESE	IFNLR1	476	Q8IU57
DEEEININLREESDW	GREB1	1376	Q4ZG55
DDLSWTEEEEEEEAM	ITGB1BP2	331	Q9UKP3
ETTEEEEEEEEVPWT	KIF1B	726	O60333
EEEEEEVPWTQHEFE	KIF1B	731	O60333
VSEAEGGIREWEEEE	EIF4E1B	6	A6NMX2
ELEDILEEDEDSAEW	BSN	776	Q9UPA5
DEDDDRGEEWERHEA	GPATCH3	291	Q96I76
DQDSSDDERALEDWV	DCAF8	126	Q5TAQ9
WETEVVEFERETEDI	DLG5	616	Q8TDM6
QDEDEERWQGREEES	NEK11	416	Q8NG66
EAEGEWEEEKLSDRE	MACF1	331	O94854
TWELEEFREGIEEED	LAS1L	196	Q9Y4W2
ERWISDEEDEASSDE	LRRC46	171	Q96FV0
WDDDEVEWEEDVVDA	ANKS4B	331	Q8N8V4
EEEEEQELRWMELDS	ANKRD65	11	E5RJM6
AEEEEEDDASKEREW	NFKBIL1	151	Q9UBC1
DEHTEETLPQEEWEE	MROH1	591	Q8NDA8
DEEQKVWDEEIDDDD	ERMN	176	Q8TAM6
LTWLETAEEEESEEE	EIF4G2	891	P78344
LEDFIFDEAALEEEW	LRRIQ1	1436	Q96JM4
SSEEEEIDVVDWTAE	BTBD18	671	B2RXH4
EEEEEDNEGGEWERV	EIF3CL	291	B5ME19
NEDIEFIEIDRWEQE	DNAH6	246	Q9C0G6
LREEEWDEEEEEEAD	HTT	2631	P42858
GDWEIDVESLELEED	DMRT2	11	Q9Y5R5
DDEAEEIQWSDDENT	CDC123	61	O75794
SWVEFIELDIDEPDE	GHR	341	P10912
SVDLSEVEWEDRDDV	CACNA2D3	556	Q8IZS8
WEPSLESEEEVEEEE	GGT6	16	Q6P531
CDVLVEEFEEVIEDW	CNPY3	166	Q9BT09
EAELVSEETEGWEEV	HAP1	581	P54257
SEETEGWEEVELELD	HAP1	586	P54257
TWELTEEEEAEDQED	FOXR1	126	Q6PIV2
EDDWIEFSSEEIREA	ANK3	1986	Q12955
EWNLRQEEIDESDDD	ASAP1	706	Q9ULH1
DPETQEWLEETDSEE	KLHDC4	481	Q8TBB5
EWLEETDSEEDSEEV	KLHDC4	486	Q8TBB5
DDVPEWQQDEFDEEL	CUL9	2471	Q8IWT3
ESRAFHEWDEDADID	FBXL5	281	Q9UKA1
EDWEDEFDLENAVLF	GYS1	16	P13807
DDEEAGWTELAEQEV	HPS6	476	Q86YV9
YEASDLTWEEEEEEE	NPM2	121	Q86SE8
RIQPFDDDEDEDIWE	PPP6R2	626	O75170
EEEDDDWDEEVLEET	IPO8	926	O15397
DWDEEVLEETALEGF	IPO8	931	O15397
EEDIWFDDVDPADIE	REXO4	191	Q9GZR2
MEDEEVAESWEEAAD	SZRD1	1	Q7Z422
EEEEEEEAPVSVWDE	RGL2	46	O15211
REEADAWNRDEAVEE	NUGGC	181	Q68CJ6
EEEVEEEEEGVFWTS	TRIM41	96	Q8WV44
AWTLEGEEEEEEEYE	NAP1L5	131	Q96NT1
TAWEDEAENEPEEEL	ARHGAP27	326	Q6ZUM4
DEDDDEITPDLWQEA	POLR2B	11	P30876
PEEVVDDEEFDWEIE	SHQ1	116	Q6PI26
DDEEFDWEIEQTPCE	SHQ1	121	Q6PI26
EEEDEDVSTERWHQG	HRC	351	P23327
AGIQWSEEETEDEEE	NOP2	176	P46087
DVEDEDWDISSLEEE	DZIP1	786	Q86YF9
ERLRSWEQEEEEEEV	APOBR	171	Q0VD83
VWVLEEEGDEEREAE	APOBR	406	Q0VD83
RDENEKIWDEDEEST	ARMCX1	31	Q9P291
DSSEDEVDWQDTRDD	RIOK3	126	O14730
QDDLEEDDVFLLDVW	VIL1	641	P09327
DAVEDLTEAEWEDLT	TTLL8	291	A6PVC2
RSWEDFEEELEARLE	TICRR	71	Q7Z2Z1
EWSDESEEELEEELE	SPDYE4	56	A6NLX3
DWFESFLDDEEDLDV	PRPF38B	176	Q5VTL8
QEEAAVEEEEDWRED	TNNT2	16	P45379
VEEEEDWREDEDEQE	TNNT2	21	P45379
DWREDEDEQEEAAEE	TNNT2	26	P45379
FDTEEERQQWEDDQR	DHX38	306	Q92620
VDDDDDDDLERVSWS	VIPAS39	46	Q9H9C1
EVEVEREGWSEDEEE	TRIM26	371	Q12899
AEEEEEELWSDSEHN	TET3	1631	O43151
LTDDREEEENWDQQD	SETD2	1331	Q9BYW2
SWEEEEEEEEREEDL	TRH	166	P20396
EIVQESWRKEYEEDD	TGS1	136	Q96RS0
EEESENDWEEVEELS	XPC	126	Q01831
EERAIEVDSDWVEEL	UBR4	1626	Q5T4S7
EVDSDWVEELAVEEE	UBR4	1631	Q5T4S7
WVEELAVEEEDSQAE	UBR4	1636	Q5T4S7
DDDDERENFEITDWD	TFIP11	16	Q9UBB9
RQARTETVVDDWDEE	USP36	1061	Q9P275
ESEEENVEWETNRDD	ZC3H13	136	Q5T200
DWSDEDVPDRTEVTE	ZC3H13	1066	Q5T200