Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cell adhesion molecule binding	NPHS1 TJP1 APC LAMB1 CASR ACTN2 EMD DMD VSIG10L2	1.17e-04	599	64	9	GO:0050839
GeneOntologyBiologicalProcess	epithelium development	CRYAA MAGI2 NCOR1 IL17A TCHH DMRT2 ALMS1 TJP1 PPP1R12A APC LRP4 CASR PRKDC DMD GRSF1 MED12 SOS1	1.24e-06	1469	63	17	GO:0060429
GeneOntologyBiologicalProcess	regulation of G1/S transition of mitotic cell cycle	RBL2 APC SMARCC1 SMARCC2 PRKDC RRM1	4.70e-05	213	63	6	GO:2000045
GeneOntologyCellularComponent	nuclear lamina	PRR14 EMD LBR	1.72e-05	17	63	3	GO:0005652
GeneOntologyCellularComponent	postsynaptic density	MAGI2 NSG2 LRP4 PLEKHA5 LRRC7 ACTN2 DMD ADCY1	6.04e-05	451	63	8	GO:0014069
GeneOntologyCellularComponent	asymmetric synapse	MAGI2 NSG2 LRP4 PLEKHA5 LRRC7 ACTN2 DMD ADCY1	8.93e-05	477	63	8	GO:0032279
GeneOntologyCellularComponent	postsynaptic specialization	MAGI2 NSG2 LRP4 PLEKHA5 LRRC7 ACTN2 DMD ADCY1	1.29e-04	503	63	8	GO:0099572
GeneOntologyCellularComponent	anchoring junction	NPHS1 MAGI2 DSG3 TJP1 PPP1R12A APC LRRC7 ACTN2 DMD VSIG10L2 FRMD4B	1.44e-04	976	63	11	GO:0070161
GeneOntologyCellularComponent	nuclear periphery	PRR14 SMARCC1 SMARCC2 EMD LBR	1.65e-04	171	63	5	GO:0034399
GeneOntologyCellularComponent	neuron to neuron synapse	MAGI2 NSG2 LRP4 PLEKHA5 LRRC7 ACTN2 DMD ADCY1	1.68e-04	523	63	8	GO:0098984
GeneOntologyCellularComponent	kinetochore	PPP1R12A APC SMARCC1 SMARCC2 FBXW11	2.16e-04	181	63	5	GO:0000776
GeneOntologyCellularComponent	condensed chromosome, centromeric region	PPP1R12A APC SMARCC1 SMARCC2 FBXW11	2.90e-04	193	63	5	GO:0000779
GeneOntologyCellularComponent	cell-cell junction	NPHS1 MAGI2 DSG3 TJP1 APC LRRC7 VSIG10L2 FRMD4B	3.84e-04	591	63	8	GO:0005911
GeneOntologyCellularComponent	adherens junction	DSG3 TJP1 APC LRRC7 FRMD4B	4.46e-04	212	63	5	GO:0005912
GeneOntologyCellularComponent	filtration diaphragm	NPHS1 MAGI2	4.83e-04	11	63	2	GO:0036056
GeneOntologyCellularComponent	slit diaphragm	NPHS1 MAGI2	4.83e-04	11	63	2	GO:0036057
GeneOntologyCellularComponent	bicellular tight junction	MAGI2 TJP1 APC FRMD4B	6.59e-04	131	63	4	GO:0005923
GeneOntologyCellularComponent	npBAF complex	SMARCC1 SMARCC2	7.95e-04	14	63	2	GO:0071564
GeneOntologyCellularComponent	brahma complex	SMARCC1 SMARCC2	7.95e-04	14	63	2	GO:0035060
GeneOntologyCellularComponent	tight junction	MAGI2 TJP1 APC FRMD4B	8.23e-04	139	63	4	GO:0070160
GeneOntologyCellularComponent	RSC-type complex	SMARCC1 SMARCC2	9.15e-04	15	63	2	GO:0016586
GeneOntologyCellularComponent	somatodendritic compartment	MAGI2 NSG2 APC LRP4 CASR LRRC7 ACTN2 DMD RRM1 FBXW11 SOS1	1.01e-03	1228	63	11	GO:0036477
GeneOntologyCellularComponent	nBAF complex	SMARCC1 SMARCC2	1.04e-03	16	63	2	GO:0071565
GeneOntologyCellularComponent	postsynaptic density membrane	NSG2 LRRC7 ACTN2 ADCY1	1.29e-03	157	63	4	GO:0098839
GeneOntologyCellularComponent	apical junction complex	MAGI2 TJP1 APC FRMD4B	1.32e-03	158	63	4	GO:0043296
GeneOntologyCellularComponent	postsynaptic membrane	MAGI2 NSG2 LRRC7 ACTN2 DMD ADCY1	1.36e-03	405	63	6	GO:0045211
GeneOntologyCellularComponent	chromosome, centromeric region	PPP1R12A APC SMARCC1 SMARCC2 FBXW11	1.46e-03	276	63	5	GO:0000775
GeneOntologyCellularComponent	chromosomal region	PPP1R12A APC SMARCC1 SMARCC2 PRKDC FBXW11	1.66e-03	421	63	6	GO:0098687
GeneOntologyCellularComponent	synaptic membrane	MAGI2 NSG2 LRP4 LRRC7 ACTN2 DMD ADCY1	1.81e-03	583	63	7	GO:0097060
GeneOntologyCellularComponent	condensed chromosome	PPP1R12A APC SMARCC1 SMARCC2 FBXW11	2.32e-03	307	63	5	GO:0000793
GeneOntologyCellularComponent	astrocyte projection	KCNJ10 DMD	2.56e-03	25	63	2	GO:0097449
GeneOntologyCellularComponent	glutamatergic synapse	MAGI2 NSG2 APC PLEKHA5 CASR LRRC7 ACTN2 ADCY1	3.04e-03	817	63	8	GO:0098978
GeneOntologyCellularComponent	postsynaptic specialization membrane	NSG2 LRRC7 ACTN2 ADCY1	3.17e-03	201	63	4	GO:0099634
GeneOntologyCellularComponent	postsynapse	MAGI2 NSG2 APC LRP4 PLEKHA5 LRRC7 ACTN2 DMD ADCY1	3.30e-03	1018	63	9	GO:0098794
GeneOntologyCellularComponent	SWI/SNF complex	SMARCC1 SMARCC2	3.68e-03	30	63	2	GO:0016514
Domain	SMARCC_C	SMARCC1 SMARCC2	1.12e-05	2	63	2	IPR032451
Domain	SMARCC_N	SMARCC1 SMARCC2	1.12e-05	2	63	2	IPR032450
Domain	SWIRM-assoc	SMARCC1 SMARCC2	1.12e-05	2	63	2	IPR032448
Domain	SWIRM-assoc_2	SMARCC1 SMARCC2	1.12e-05	2	63	2	PF16496
Domain	SWIRM-assoc_1	SMARCC1 SMARCC2	1.12e-05	2	63	2	PF16495
Domain	SWIRM-assoc_3	SMARCC1 SMARCC2	1.12e-05	2	63	2	PF16498
Domain	SANT_dom	NCOR1 SMARCC1 SMARCC2	9.00e-05	26	63	3	IPR017884
Domain	SANT	NCOR1 SMARCC1 SMARCC2	1.13e-04	28	63	3	PS51293
Domain	SWIRM	SMARCC1 SMARCC2	1.67e-04	6	63	2	PS50934
Domain	SWIRM	SMARCC1 SMARCC2	1.67e-04	6	63	2	PF04433
Domain	SWIRM	SMARCC1 SMARCC2	1.67e-04	6	63	2	IPR007526
Domain	Myb_DNA-binding	NCOR1 SMARCC1 SMARCC2	2.22e-04	35	63	3	PF00249
Domain	MYB_LIKE	NCOR1 SMARCC1 SMARCC2	2.84e-04	38	63	3	PS50090
Domain	WW	MAGI2 PLEKHA5 DMD	5.34e-04	47	63	3	PF00397
Domain	WW	MAGI2 PLEKHA5 DMD	5.68e-04	48	63	3	SM00456
Domain	SANT	NCOR1 SMARCC1 SMARCC2	6.40e-04	50	63	3	SM00717
Domain	WW_DOMAIN_2	MAGI2 PLEKHA5 DMD	6.79e-04	51	63	3	PS50020
Domain	WW_DOMAIN_1	MAGI2 PLEKHA5 DMD	6.79e-04	51	63	3	PS01159
Domain	WW_dom	MAGI2 PLEKHA5 DMD	7.18e-04	52	63	3	IPR001202
Domain	SANT/Myb	NCOR1 SMARCC1 SMARCC2	7.18e-04	52	63	3	IPR001005
Domain	ZU5	TJP1 SH3BP4	7.23e-04	12	63	2	PF00791
Domain	ZU5_dom	TJP1 SH3BP4	7.23e-04	12	63	2	IPR000906
Domain	-	CAPN8 TCHH PLCH2 ACTN2 DMD	1.86e-03	261	63	5	1.10.238.10
Domain	Actinin_actin-bd_CS	ACTN2 DMD	2.71e-03	23	63	2	IPR001589
Domain	Pentatricopeptide_repeat	DENND4A PRKDC	2.71e-03	23	63	2	IPR002885
Domain	Spectrin	ACTN2 DMD	2.71e-03	23	63	2	PF00435
Domain	GUANYLATE_KINASE_2	MAGI2 TJP1	2.71e-03	23	63	2	PS50052
Domain	GUANYLATE_KINASE_1	MAGI2 TJP1	2.71e-03	23	63	2	PS00856
Domain	ACTININ_2	ACTN2 DMD	2.71e-03	23	63	2	PS00020
Domain	ACTININ_1	ACTN2 DMD	2.71e-03	23	63	2	PS00019
Domain	EF-hand-dom_pair	CAPN8 TCHH PLCH2 ACTN2 DMD	2.81e-03	287	63	5	IPR011992
Domain	Guanylate_kin	MAGI2 TJP1	3.45e-03	26	63	2	PF00625
Domain	GK/Ca_channel_bsu	MAGI2 TJP1	3.45e-03	26	63	2	IPR008145
Domain	Guanylate_kin-like_dom	MAGI2 TJP1	3.45e-03	26	63	2	IPR008144
Domain	GuKc	MAGI2 TJP1	3.45e-03	26	63	2	SM00072
Domain	BRCT_dom	SMARCC1 SMARCC2	4.00e-03	28	63	2	IPR001357
Domain	Spectrin_repeat	ACTN2 DMD	4.29e-03	29	63	2	IPR002017
Domain	Spectrin/alpha-actinin	ACTN2 DMD	5.20e-03	32	63	2	IPR018159
Domain	SPEC	ACTN2 DMD	5.20e-03	32	63	2	SM00150
Domain	Chromo/shadow_dom	SMARCC1 SMARCC2	5.53e-03	33	63	2	IPR000953
Domain	CHROMO	SMARCC1 SMARCC2	5.53e-03	33	63	2	SM00298
Pathway	WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY	EMD LBR ADCY1 SOS1	3.00e-05	46	55	4	M39828
Pathway	REACTOME_NEPHRIN_FAMILY_INTERACTIONS	NPHS1 MAGI2 ACTN2	9.42e-05	23	55	3	M913
Pathway	BIOCARTA_VDR_PATHWAY	NCOR1 SMARCC1 SMARCC2	1.07e-04	24	55	3	M13404
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	NCOR1 ALMS1 TJP1 UBAP2L PPP1R12A ATG2B SMARCC1 PLEKHA5 RPRD2 PRKDC MED12	4.80e-09	549	64	11	38280479
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	DENND4A INPP5E PPP1R12A PLEKHA5 PRKDC LBR RRM1 SH3BP4	2.32e-08	255	64	8	15324660
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	NCOR1 TJP1 INPP5E PPP1R12A APC SMARCC1 LAMB1 SMARCC2 PRKDC EMD LBR MED12 FBXW11 SH3BP4	4.84e-08	1247	64	14	27684187
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	ALMS1 TJP1 APC PLEKHA5 LRRC7 EMD LBR	5.62e-07	263	64	7	34702444
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	UBAP2L ATG2B APC PLEKHA5 LRRC7 PRKDC EMD LBR RRM1 MED12	6.46e-07	708	64	10	39231216
Pubmed	Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase.	NUAK1 PPP1R12A FBXW11	1.29e-06	12	64	3	24785407
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MAGI2 NCOR1 TJP1 UBAP2L PPP1R12A KCNJ10 APC SMARCC1 SMARCC2 PLEKHA5 LRRC7	1.35e-06	963	64	11	28671696
Pubmed	An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture.	NCOR1 SMARCC1 SMARCC2 EMD	1.91e-06	48	64	4	17620012
Pubmed	Deletion of astroglial connexins weakens the blood-brain barrier.	TJP1 KCNJ10 DMD	2.13e-06	14	64	3	22472609
Pubmed	A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1.	NCOR1 SMARCC1 SMARCC2	3.27e-06	16	64	3	11013263
Pubmed	T and B lymphocyte depletion has a marked effect on the fibrosis of dystrophic skeletal muscles in the scid/mdx mouse.	PRKDC DMD	3.33e-06	2	64	2	17668421
Pubmed	The Swi3 protein plays a unique role in regulating respiration in eukaryotes.	SMARCC1 SMARCC2	3.33e-06	2	64	2	27190130
Pubmed	Human muscle-derived cell populations isolated by differential adhesion rates: phenotype and contribution to skeletal muscle regeneration in Mdx/SCID mice.	PRKDC DMD	3.33e-06	2	64	2	21854253
Pubmed	Transplantation-based screen identifies inducers of muscle progenitor cell engraftment across vertebrate species.	PRKDC DMD	3.33e-06	2	64	2	37018075
Pubmed	Frequency and histological appearance of adenomas in multiple intestinal neoplasia mice are unaffected by severe combined immunodeficiency (scid) mutation.	APC PRKDC	3.33e-06	2	64	2	8567125
Pubmed	Calcium-sensing receptor decreases cell surface expression of the inwardly rectifying K+ channel Kir4.1.	KCNJ10 CASR	3.33e-06	2	64	2	21084311
Pubmed	Spectrin-like repeats from dystrophin and alpha-actinin-2 are not functionally interchangeable.	ACTN2 DMD	3.33e-06	2	64	2	12140183
Pubmed	Increasing LRP4 diminishes neuromuscular deficits in a mouse model of Duchenne muscular dystrophy.	LRP4 DMD	3.33e-06	2	64	2	33987657
Pubmed	Chemokine/ITGA4 Interaction Directs iPSC-Derived Myogenic Progenitor Migration to Injury Sites in Aging Muscle for Regeneration.	PRKDC DMD	3.33e-06	2	64	2	37508502
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PITRM1 NUAK1 INPP5E PLCH2 LRP4 PLEKHA5 RPRD2 FRMD4B	5.70e-06	529	64	8	14621295
Pubmed	Identification of the hypoxia-inducible factor 2α nuclear interactome in melanoma cells reveals master proteins involved in melanoma development.	SMARCC1 SMARCC2 EMD MED12	6.90e-06	66	64	4	23275444
Pubmed	The Wilms tumor gene, Wt1, maintains testicular cord integrity by regulating the expression of Col4a1 and Col4a2.	TJP1 LAMB1 PLEKHA5	7.72e-06	21	64	3	23325811
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	TJP1 UBAP2L ATG2B APC PLEKHA5 PRKDC	7.87e-06	256	64	6	33397691
Pubmed	Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis.	IL17A APC	9.99e-06	3	64	2	20212110
Pubmed	Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress.	NUAK1 APC	9.99e-06	3	64	2	29500295
Pubmed	Adenoma multiplicity in irradiated Apc(Min) mice is modified by chromosome 16 segments from BALB/c.	APC PRKDC	9.99e-06	3	64	2	12750251
Pubmed	BAF chromatin remodeling complex: cortical size regulation and beyond.	SMARCC1 SMARCC2	9.99e-06	3	64	2	23974113
Pubmed	Spontaneous Intestinal Tumorigenesis in Apc (/Min+) Mice Requires Altered T Cell Development with IL-17A.	IL17A APC	9.99e-06	3	64	2	26146642
Pubmed	Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment.	PRKDC DMD	9.99e-06	3	64	2	35395188
Pubmed	Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next-generation human artificial chromosomes for Duchenne muscular dystrophy.	PRKDC DMD	9.99e-06	3	64	2	29242210
Pubmed	SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating β-Catenin Nuclear Localization.	APC SH3BP4	9.99e-06	3	64	2	30811977
Pubmed	Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ mice.	APC PRKDC	9.99e-06	3	64	2	19194513
Pubmed	Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability.	NPHS1 TJP1	9.99e-06	3	64	2	12865409
Pubmed	Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice.	IL17A DSG3	9.99e-06	3	64	2	21821914
Pubmed	Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function.	KCNJ10 CASR	9.99e-06	3	64	2	17122384
Pubmed	Cenani-Lenz syndrome and other related syndactyly disorders due to variants in LRP4, GREM1/FMN1, and APC: Insight into the pathogenesis and the relationship to polyposis through the WNT and BMP antagonistic pathways.	APC LRP4	9.99e-06	3	64	2	30569497
Pubmed	Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility.	NUAK1 PPP1R12A	9.99e-06	3	64	2	30446640
Pubmed	Cell-mediated exon skipping normalizes dystrophin expression and muscle function in a new mouse model of Duchenne Muscular Dystrophy.	PRKDC DMD	9.99e-06	3	64	2	38438561
Pubmed	Regulatory T-cell Response to Enterotoxigenic Bacteroides fragilis Colonization Triggers IL17-Dependent Colon Carcinogenesis.	IL17A APC	9.99e-06	3	64	2	26201900
Pubmed	Dystrophin Short Product, Dp71, Interacts with AQP4 and Kir4.1 Channels in the Mouse Cerebellar Glial Cells in Contrast to Dp427 at Inhibitory Postsynapses in the Purkinje Neurons.	KCNJ10 DMD	9.99e-06	3	64	2	36918517
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	NCOR1 UBAP2L ENTPD6 LAMB1 SMARCC2 PLEKHA5 ACTN2 BEND2	1.56e-05	608	64	8	16713569
Pubmed	An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies.	KCNJ10 APC LAMB1 ACTN2	1.80e-05	84	64	4	15123239
Pubmed	Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome.	PRKDC EMD	2.00e-05	4	64	2	21346760
Pubmed	Early glomerular filtration defect and severe renal disease in podocin-deficient mice.	NPHS1 TJP1	2.00e-05	4	64	2	14701729
Pubmed	Altered blood-brain barrier development in dystrophic MDX mice.	TJP1 DMD	2.00e-05	4	64	2	15120852
Pubmed	Clearance of Staphylococcus aureus nasal carriage is T cell dependent and mediated through interleukin-17A expression and neutrophil influx.	IL17A PRKDC	2.00e-05	4	64	2	23529621
Pubmed	The tumor suppressor hSNF5/INI1 modulates cell growth and actin cytoskeleton organization.	SMARCC1 SMARCC2	2.00e-05	4	64	2	15150092
Pubmed	The murine Bin1 gene functions early in myogenesis and defines a new region of synteny between mouse chromosome 18 and human chromosome 2.	DSG3 APC	2.00e-05	4	64	2	10036185
Pubmed	HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics.	EMD LBR	2.00e-05	4	64	2	11034899
Pubmed	Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice.	TJP1 DMD	2.00e-05	4	64	2	12673830
Pubmed	A role for nephrin, a renal protein, in vertebrate skeletal muscle cell fusion.	NPHS1 DMD	2.00e-05	4	64	2	19470472
Pubmed	Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer.	APC PRKDC	2.00e-05	4	64	2	35537038
Pubmed	New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion.	NUAK1 PPP1R12A	2.00e-05	4	64	2	20354225
Pubmed	The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology.	CRYAA ACTN2	2.00e-05	4	64	2	32420594
Pubmed	Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane.	NPHS1 TJP1	2.00e-05	4	64	2	21402783
Pubmed	Locus coeruleus neurons are resistant to dysfunction and degeneration by maintaining free ubiquitin levels although total ubiquitin levels decrease upon disruption of polyubiquitin gene Ubb.	PRKDC DMD	2.00e-05	4	64	2	22285186
Pubmed	MicroRNA-146a limits tumorigenic inflammation in colorectal cancer.	IL17A APC	2.00e-05	4	64	2	33893298
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	NCOR1 RPRD2 EMD LBR SH3BP4	2.09e-05	180	64	5	35198878
Pubmed	RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.	UBAP2L SMARCC1 SMARCC2	2.10e-05	29	64	3	36800290
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	NCOR1 TJP1 UBAP2L PPP1R12A APC LAMB1 SMARCC2 PRKDC LBR RRM1 GRSF1	2.25e-05	1297	64	11	33545068
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	PPP1R12A PLEKHA5 RPRD2 EMD LBR RRM1 MED12	2.59e-05	472	64	7	38943005
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DENND4A ALMS1 TJP1 INPP5E PPP1R12A APC PLEKHA5 LBR SH3BP4	2.73e-05	861	64	9	36931259
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	UBAP2L RPRD2 PRKDC EMD DMD GBA2	2.87e-05	322	64	6	26514267
Pubmed	Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.	TJP1 APC PRKDC EMD MED12	3.07e-05	195	64	5	17110338
Pubmed	A human MAP kinase interactome.	APC LAMB1 PLEKHA5 PRKDC DMD SH3BP4 SOS1	3.11e-05	486	64	7	20936779
Pubmed	Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome.	SMARCC1 SMARCC2	3.32e-05	5	64	2	9693044
Pubmed	Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.	APC PRKDC	3.32e-05	5	64	2	26107252
Pubmed	Gli1 marks a sentinel muscle stem cell population for muscle regeneration.	PRKDC DMD	3.32e-05	5	64	2	37914731
Pubmed	Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes.	SMARCC1 SMARCC2	3.32e-05	5	64	2	12244326
Pubmed	Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy.	LAMB1 DMD	3.32e-05	5	64	2	19416897
Pubmed	Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis.	IL17A APC	3.32e-05	5	64	2	26880802
Pubmed	p300/CREB binding protein-related protein p270 is a component of mammalian SWI/SNF complexes.	SMARCC1 SMARCC2	3.32e-05	5	64	2	9584200
Pubmed	Bicellular Localization of Tricellular Junctional Protein Angulin-3/ILDR2 Allows Detection of Podocyte Injury.	NPHS1 TJP1	3.32e-05	5	64	2	38311119
Pubmed	LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation.	EMD LBR	3.32e-05	5	64	2	23374351
Pubmed	The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members.	TJP1 APC	3.32e-05	5	64	2	18502210
Pubmed	Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology.	KCNJ10 DMD	3.32e-05	5	64	2	24014171
Pubmed	Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57.	SMARCC1 SMARCC2	3.32e-05	5	64	2	16199878
Pubmed	RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.	APC SOS1	3.32e-05	5	64	2	26005835
Pubmed	Members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt.	SMARCC1 SMARCC2	3.32e-05	5	64	2	16568092
Pubmed	The HSA domain of BRG1 mediates critical interactions required for glucocorticoid receptor-dependent transcriptional activation in vivo.	SMARCC1 SMARCC2	3.32e-05	5	64	2	18086889
Pubmed	cDNA cloning and chromosomal assignment of the mouse gene for desmoglein 3 (Dsg3), the pemphigus vulgaris antigen.	DSG3 APC	3.32e-05	5	64	2	7894164
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TCHH ALMS1 PPP1R12A LRP4 SMARCC1 LAMB1 SMARCC2 LBR DCAF16 SOS1	3.49e-05	1116	64	10	31753913
Pubmed	Host PDZ-containing proteins targeted by SARS-CoV-2.	MAGI2 TJP1 LRRC7	3.73e-05	35	64	3	33864728
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	DENND4A ALMS1 ATG2B APC PLEKHA5	4.27e-05	209	64	5	36779422
Pubmed	Interaction network of human early embryonic transcription factors.	NCOR1 ALMS1 SMARCC1 SMARCC2 EMD MED12	4.64e-05	351	64	6	38297188
Pubmed	Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex.	TJP1 SMARCC1 SMARCC2	4.79e-05	38	64	3	30240734
Pubmed	Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex.	SMARCC1 SMARCC2	4.98e-05	6	64	2	16940996
Pubmed	Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2.	LRRC7 ACTN2	4.98e-05	6	64	2	16120608
Pubmed	Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer.	RBL2 PRKDC	4.98e-05	6	64	2	27373157
Pubmed	The Alström syndrome protein, ALMS1, interacts with α-actinin and components of the endosome recycling pathway.	ALMS1 ACTN2	4.98e-05	6	64	2	22693585
Pubmed	Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis.	IL17A APC	4.98e-05	6	64	2	24412611
Pubmed	Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors.	PRKDC DMD	4.98e-05	6	64	2	29742392
Pubmed	Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.	RBL2 PRKDC	4.98e-05	6	64	2	21875955
Pubmed	BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer.	SMARCC1 SMARCC2	4.98e-05	6	64	2	10943845
Pubmed	Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response.	NPHS1 TJP1	4.98e-05	6	64	2	26076477
Pubmed	Varying modulation of HIV-1 LTR activity by Baf complexes.	SMARCC1 SMARCC2	4.98e-05	6	64	2	21699904
Pubmed	Variations in the composition of mammalian SWI/SNF chromatin remodelling complexes.	SMARCC1 SMARCC2	4.98e-05	6	64	2	19650111
Pubmed	Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression.	SMARCC1 SMARCC2	4.98e-05	6	64	2	21095589
Pubmed	The p270 (ARID1A/SMARCF1) subunit of mammalian SWI/SNF-related complexes is essential for normal cell cycle arrest.	SMARCC1 SMARCC2	4.98e-05	6	64	2	16230384
Pubmed	Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer.	IL17A APC	4.98e-05	6	64	2	30650375
Interaction	RCOR1 interactions	CRYAA NCOR1 ALMS1 PPP1R12A ATG2B APC SMARCC1 SMARCC2 PLEKHA5 EMD MED12	3.35e-07	494	63	11	int:RCOR1
Interaction	NCAPH2 interactions	NCOR1 PRR14 ALMS1 SMARCC1 ACTN2 EMD MED12	9.60e-07	169	63	7	int:NCAPH2
Interaction	EPAS1 interactions	RBL2 APC SMARCC1 SMARCC2 PRKDC EMD MED12	1.12e-06	173	63	7	int:EPAS1
Interaction	WWTR1 interactions	NCOR1 ALMS1 TJP1 PPP1R12A ATG2B SMARCC1 PLEKHA5 RPRD2 FBXW11	6.19e-06	422	63	9	int:WWTR1
Interaction	MAGI1 interactions	DENND4A TJP1 INPP5E KCNJ10 PLEKHA5 SH3BP4	6.56e-06	147	63	6	int:MAGI1
Interaction	TRIM33 interactions	CRYAA NCOR1 UBAP2L RBL2 SMARCC1 SMARCC2 TGM7 PRKDC RRM1	1.09e-05	453	63	9	int:TRIM33
Interaction	SIPA1L1 interactions	DENND4A TJP1 INPP5E PLEKHA5 FBXW11 SH3BP4	1.72e-05	174	63	6	int:SIPA1L1
Interaction	SRCAP interactions	NCOR1 SMARCC1 SMARCC2 MED12 IFNLR1	4.82e-05	127	63	5	int:SRCAP
Interaction	YWHAB interactions	DENND4A NUAK1 TJP1 INPP5E PPP1R12A APC COP1 PLEKHA5 EMD LBR FBXW11 SH3BP4	6.11e-05	1014	63	12	int:YWHAB
Interaction	LATS1 interactions	ALMS1 NUAK1 TJP1 PPP1R12A APC SMARCC1 PLEKHA5 EMD	6.56e-05	440	63	8	int:LATS1
Interaction	KCNJ12 interactions	KCNJ10 EMD DMD	9.02e-05	28	63	3	int:KCNJ12
Interaction	YWHAG interactions	DENND4A ALMS1 NUAK1 TJP1 INPP5E PPP1R12A APC PLEKHA5 PRKDC LBR RRM1 FBXW11 SH3BP4	1.06e-04	1248	63	13	int:YWHAG
Interaction	YWHAE interactions	DENND4A PITRM1 NUAK1 INPP5E PPP1R12A APC SMARCC2 PLEKHA5 EMD LBR FRMD4B FBXW11 SH3BP4	1.13e-04	1256	63	13	int:YWHAE
Interaction	EIF4E2 interactions	DENND4A UBAP2L INPP5E PLEKHA5 FBXW11 SH3BP4	1.18e-04	246	63	6	int:EIF4E2
Interaction	DOCK1 interactions	NUAK1 DMD FBXW11 SOS1	1.26e-04	82	63	4	int:DOCK1
Interaction	BTRC interactions	CRYAA ALMS1 NUAK1 TJP1 UBAP2L APC RPRD2 EMD IFNLR1 FBXW11	1.35e-04	775	63	10	int:BTRC
Interaction	SMARCB1 interactions	NCOR1 PPP1R12A APC SMARCC1 SMARCC2 EMD DPH6	1.37e-04	364	63	7	int:SMARCB1
Interaction	SH3BP5L interactions	PPP1R12A PLEKHA5 FBXW11	1.49e-04	33	63	3	int:SH3BP5L
Interaction	FLNA interactions	TJP1 PPP1R12A APC COP1 CASR PRKDC DCAF16 RRM1 FBXW11	1.74e-04	648	63	9	int:FLNA
Interaction	TNIK interactions	MAGI2 TJP1 APC SMARCC2 PLEKHA5 LRRC7 SOS1	1.82e-04	381	63	7	int:TNIK
Interaction	C6orf141 interactions	NCOR1 PRR14 ALMS1 ATG2B	1.97e-04	92	63	4	int:C6orf141
Interaction	GIGYF1 interactions	DENND4A UBAP2L INPP5E PLEKHA5 SH3BP4	2.30e-04	177	63	5	int:GIGYF1
Interaction	NUAK1 interactions	NUAK1 UBAP2L PPP1R12A FBXW11	2.32e-04	96	63	4	int:NUAK1
Interaction	TESK2 interactions	DENND4A INPP5E PLEKHA5 SH3BP4	2.42e-04	97	63	4	int:TESK2
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	NCOR1 SMARCC1 SMARCC2	3.09e-04	53	45	3	532
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#5	RSPH3 UBAP2L PPP1R12A PLCH2 APC COP1 SMARCC2 PNPLA8 DMD SOS1	1.30e-05	629	62	10	Facebase_RNAseq_e10.5_Maxillary Arch_2500_K5
ToppCell	TCGA-Blood_and_Bone_Marrow-Primary_Tumor-Diffuse_large_B-cell_lymphoma-DLBCL-1\|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9	NUAK1 TJP1 ASAH2 KCNJ10 LAMB1 DMD IFNLR1	1.25e-08	194	64	7	eaeeb84576270cc3fc59002ba33bff9639bb0b02
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NSG2 TJP1 LAMB1 SLC35F1 ADAMTSL3	7.35e-06	187	64	5	fa01a61bfd13feb033ba1e35cf513707b1bff8c8
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DMRT2 TJP1 LAMB1 SLC35F1 ADAMTSL3	7.35e-06	187	64	5	a2bf958ea59c359a265bfa437d59315e1920cdd4
ToppCell	Mesenchymal-pericyte_cell\|World / Lineage, Cell type, age group and donor	DMRT2 TJP1 LAMB1 SLC35F1 ADAMTSL3	7.74e-06	189	64	5	d7ed96add29f219183c802895fbff519b627f635
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAGI2 LRP4 SLC35F1 DMD ADAMTSL3	8.14e-06	191	64	5	08042952431ca1a6fd7dfc13f36eb28643979598
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAGI2 LRP4 SLC35F1 DMD ADAMTSL3	8.35e-06	192	64	5	992d08092edbc68c47b945deb8708379738c239a
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NUAK1 LAMB1 ACTN2 ADAMTSL3 ADCY1	8.56e-06	193	64	5	b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell	facs-Thymus-Thymus_Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TJP1 LRP4 LAMB1 DMD ADAMTSL3	9.23e-06	196	64	5	6bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCell	facs-Thymus-Thymus_Epithelium-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TJP1 LRP4 LAMB1 DMD ADAMTSL3	9.23e-06	196	64	5	c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area\|World / Primary Cells by Cluster	NSG2 NUAK1 PLEKHA5 DMD ADCY1	9.46e-06	197	64	5	79b9e7f2e8e33b3c547f716be5667156c48b0dfc
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area-33\|World / Primary Cells by Cluster	NSG2 NUAK1 PLEKHA5 DMD ADCY1	9.46e-06	197	64	5	d20f29088e9afd8a960d6f680075c380e550f8a7
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Pericyte\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PPP1R12A LAMB1 SLC35F1 DMD ADAMTSL3	1.02e-05	200	64	5	b22cae282591d8dead9869c2adbb9632615f50f7
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-CPNs\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	NSG2 LRRC7 ACTN2 ADCY1 FRMD4B	1.02e-05	200	64	5	71cbefbef4ae5bbb5f6e419914f4b3b3b5a5f9e3
ToppCell	lymphoid-T_cell-pro-T_cell\|T_cell / Lineage, cell class and subclass	NPHS1 TCHH KCNJ10 LAMB1	8.29e-05	160	64	4	66fe86d2f37983761141e5bb3de127f0b4bb0951
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	PITRM1 GBA2 FRMD4B MED12	1.12e-04	173	64	4	090dc3c5bd2652a65c2490fc889da858c3af368f
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNJ10 SLC35F1 DMD IFNLR1	1.12e-04	173	64	4	922356a5b4c84607318ac24d7caa2e235b72b066
ToppCell	356C-Lymphocytic-ILC\|356C / Donor, Lineage, Cell class and subclass (all cells)	DMRT2 PLCH2 BEND2 IL5RA	1.17e-04	175	64	4	7fa8330ce813c48bd332be618909e5ec8d0f5d7e
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALMS1 PLCH2 PLEKHA5 ADCY1	1.17e-04	175	64	4	65571d775d26a40e979dbf290a8e4320c0d9fb3f
ToppCell	356C-Lymphocytic-ILC\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DMRT2 PLCH2 BEND2 IL5RA	1.22e-04	177	64	4	7ddd7d1854ad42abd630ad0c702105102cec93e7
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TJP1 LAMB1 SLC35F1 ADAMTSL3	1.25e-04	178	64	4	185b44700f06ec58b3c09c80520502166c965fd6
ToppCell	PBMC-Severe-cDC_11\|Severe / Compartment, Disease Groups and Clusters	LAMB1 PLEKHA5 DMD ADCY1	1.25e-04	178	64	4	0667abc05eb2254710b9c648c65b7cfdfe7831b7
ToppCell	356C-Lymphocytic-ILC-ILC-1\|356C / Donor, Lineage, Cell class and subclass (all cells)	DMRT2 PLCH2 BEND2 IL5RA	1.25e-04	178	64	4	40df4bb0978e5e5568c52ad4a5881ea0cdc6941d
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAGI2 NUAK1 LRRC7 ACTN2	1.31e-04	180	64	4	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	356C-Lymphocytic-ILC-ILC-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DMRT2 PLCH2 BEND2 IL5RA	1.31e-04	180	64	4	cedbe692c5257fb6f9a552e2f197163626ac17d9
ToppCell	normal_Lung-Fibroblasts-Pericytes\|normal_Lung / Location, Cell class and cell subclass	DMRT2 NSG2 LAMB1 ADAMTSL3	1.33e-04	181	64	4	f74941e49950027360d71ea3b205fc20c6929766
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN8 MAGI2 PLEKHA5 CASR	1.33e-04	181	64	4	22363c5835dd6cef8f895ab9362e0837d92b15b1
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAGI2 LRP4 DMD ADAMTSL3	1.39e-04	183	64	4	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRRC7 DMD BEND2 ADAMTSL3	1.42e-04	184	64	4	e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAGI2 LRP4 DMD ADAMTSL3	1.45e-04	185	64	4	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DMRT2 TJP1 LAMB1 ADAMTSL3	1.45e-04	185	64	4	a7dba7db79275884b2a93d8a16f2e0c739e71370
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(RGS5+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NPHS1 DMD FRMD4B SH3BP4	1.45e-04	185	64	4	11fbea1eb1d9a3e4480d0d2b0f7b02e2866b8142
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNJ10 LAMB1 SLC35F1 DMD	1.48e-04	186	64	4	6f88b68735d0f7c9904eb8413e6007910d556185
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NUAK1 LRP4 LAMB1 CASR	1.48e-04	186	64	4	360c3e9e5c3a943e68e6939b4a47821bfc75b553
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	ALMS1 PPP1R12A APC SOS1	1.48e-04	186	64	4	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	NUAK1 LAMB1 ACTN2 ADAMTSL3	1.51e-04	187	64	4	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KCNJ10 LRP4 FRMD4B SH3BP4	1.54e-04	188	64	4	60242c29c7f16c94a84685d3bc4ed93a66e70152
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TJP1 LAMB1 ADAMTSL3 FRMD4B	1.54e-04	188	64	4	ee151792c7ac9afe820f1a281c6dab383799f358
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNJ10 LAMB1 CASR ADCY1	1.54e-04	188	64	4	14e120b20e76baa07b6510a94f0c2dcdfdd52357
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNJ10 LAMB1 CASR ADCY1	1.57e-04	189	64	4	443359d90fafae0c1de6bdcce9e8c95df6ea4de8
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LRRC7 SLC35F1 DMD ADAMTSL3	1.61e-04	190	64	4	f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LRRC7 SLC35F1 DMD ADAMTSL3	1.61e-04	190	64	4	562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAGI2 LRP4 ACTN2 DMD	1.64e-04	191	64	4	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNJ10 LAMB1 CASR ADCY1	1.67e-04	192	64	4	61c2caf6c838132ed5faa8791c288f2149eba2c8
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNJ10 LAMB1 CASR ADCY1	1.67e-04	192	64	4	e19e3e8edcc08e4a67873bfb6e46489ca6c8756a
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NPHS1 DMD FRMD4B SH3BP4	1.67e-04	192	64	4	2f539653a20006bef814e6b4acd1023d6fdad5c6
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAGI2 NUAK1 LAMB1 ACTN2	1.71e-04	193	64	4	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MAGI2 NUAK1 LAMB1 ACTN2	1.71e-04	193	64	4	99525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCell	ILEUM-inflamed-(8)_Smooth_muscle_cells\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	LRP4 LAMB1 DMD ADAMTSL3	1.71e-04	193	64	4	084c88f08ce0ecd6c9f4334caed370eb2154f896
ToppCell	COVID-19-Fibroblasts-Other_FB\|COVID-19 / group, cell type (main and fine annotations)	MAGI2 LAMB1 PLEKHA5 DMD	1.71e-04	193	64	4	e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MAGI2 NUAK1 LAMB1 ACTN2	1.74e-04	194	64	4	e93de9428c986b8943fc169258847c650cfab0e5
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	MAGI2 NUAK1 LAMB1 PLEKHA5	1.77e-04	195	64	4	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	MAGI2 LRP4 DMD SOS1	1.81e-04	196	64	4	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	Children_(3_yrs)-Mesenchymal\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MAGI2 NUAK1 LAMB1 ADAMTSL3	1.81e-04	196	64	4	bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCell	BAL-Mild-cDC_10\|Mild / Compartment, Disease Groups and Clusters	DENND4A PLEKHA5 DMD GRSF1	1.84e-04	197	64	4	c0550d41dd5619b369b590f3d6a61154dd7b2cab
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Pericyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TJP1 LAMB1 SLC35F1 ADAMTSL3	1.84e-04	197	64	4	44cd1ece3633a31e8c9b667cd3cbc2749c06f478
ToppCell	Mild\|World / Condition, Lineage, Cell class and cell subclass	NCOR1 RBL2 LAMB1 SMARCC2	1.84e-04	197	64	4	476b0d0389f9fcd4614f6bb1f494281f467f6730
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic-leukocyte\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IL17A DSG3 PPP1R12A FRMD4B	1.84e-04	197	64	4	d968d7d5608b175bb567ea3a315bf473ec3be459
ToppCell	TCGA-Skin-Metastatic-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	DENND4A ALMS1 LBR ADAMTSL3	1.88e-04	198	64	4	af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Pericyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TJP1 LAMB1 SLC35F1 ADAMTSL3	1.88e-04	198	64	4	76d46950c11cb4708866db0da54ce00d5c0adab8
ToppCell	Epithelial_cells-Basal_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	NUAK1 DSG3 PLCH2 LRP4	1.88e-04	198	64	4	4235005c49fc2b29ad3a0ee6b608f0109d04f775
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	DENND4A ALMS1 LBR ADAMTSL3	1.88e-04	198	64	4	62cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCell	TCGA-Skin-Metastatic\|TCGA-Skin / Sample_Type by Project: Shred V9	DENND4A ALMS1 LBR ADAMTSL3	1.88e-04	198	64	4	ad39cce004867f083f8da1954e0cf5a263815184
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Neuronal-CPNs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	NSG2 LRRC7 ACTN2 ADCY1	1.88e-04	198	64	4	60d8d3bbd754ffde41c50013d822667b185a9751
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6\|World / Primary Cells by Cluster	MAGI2 NSG2 NUAK1 APC	1.92e-04	199	64	4	1b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCell	Neuron\|World / Primary Cells by Cluster	NSG2 LRRC7 ADCY1 FRMD4B	1.92e-04	199	64	4	1f8104fd92f04690b41d9d07ac08dc59d76bb97d
ToppCell	Neuron-Postmitotic\|World / Primary Cells by Cluster	NSG2 LRRC7 ADCY1 FRMD4B	1.92e-04	199	64	4	1973527f8a7d4c6490d75c0d0ea153688166a08b
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal\|World / Primary Cells by Cluster	MAGI2 NSG2 NUAK1 APC	1.92e-04	199	64	4	4bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_\|World / Primary Cells by Cluster	NSG2 LRRC7 ADCY1 FRMD4B	1.92e-04	199	64	4	058373b4ac3cec2108cb24265628ff0a50646e33
ToppCell	Bronchial-NucSeq-Stromal-Pericyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DMRT2 LAMB1 SLC35F1 ADAMTSL3	1.92e-04	199	64	4	854628ce91068093c14bd4d45ba38c41469f3549
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer\|World / Primary Cells by Cluster	NSG2 ACTN2 ADCY1 FRMD4B	1.95e-04	200	64	4	db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCell	proximal-3-mesenchymal-Pericyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DMRT2 TJP1 LAMB1 ADAMTSL3	1.95e-04	200	64	4	98cbd0f4994e645f70c0bc5ebc1c3a3b28c6b67f
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PPP1R12A LAMB1 DMD ADAMTSL3	1.95e-04	200	64	4	67dcbd86fbc79fd585d0793f979e4aac100326c9
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21\|World / Primary Cells by Cluster	NSG2 ACTN2 ADCY1 FRMD4B	1.95e-04	200	64	4	30a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte\|LPS_only / Treatment groups by lineage, cell group, cell type	PPP1R12A SLC35F1 DMD ADAMTSL3	1.95e-04	200	64	4	8c8ef2b19ab5b1bfc0fae6c38a330f464f28e86f
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NUAK1 LAMB1 ACTN2 ADAMTSL3	1.95e-04	200	64	4	e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	LRP4 LAMB1 DMD ADAMTSL3	1.95e-04	200	64	4	a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell	proximal-mesenchymal-Pericyte\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DMRT2 TJP1 LAMB1 ADAMTSL3	1.95e-04	200	64	4	03119a979bc912a98e6fc87addcbc25d8ecf2fb0
ToppCell	LPS_only-Mesenchymal_myocytic\|LPS_only / Treatment groups by lineage, cell group, cell type	PPP1R12A SLC35F1 DMD ADAMTSL3	1.95e-04	200	64	4	8bc9923f82bfb836e2f524204c92050edeae8ca5
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	LRP4 LAMB1 DMD ADAMTSL3	1.95e-04	200	64	4	09537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCell	LPS_IL1RA-Mesenchymal_myocytic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PPP1R12A SLC35F1 DMD ADAMTSL3	1.95e-04	200	64	4	77631c471cc5d453a749784f838cfa6408caf09b
ToppCell	proximal-mesenchymal-Pericyte-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DMRT2 TJP1 LAMB1 ADAMTSL3	1.95e-04	200	64	4	a81fde3d40b8efb3be535aeb2a44cfbdeb17bc8b
Drug	AC1NE2UB	PPP1R12A APC EMD LBR	1.75e-05	56	63	4	CID004635684
Drug	Nimesulide [51803-78-2]; Down 200; 13uM; HL60; HG-U133A	DENND4A ALMS1 RBL2 APC ACTN2 FRMD4B	1.80e-05	198	63	6	1428_DN
Drug	Scopolamin-N-oxide hydrobromide [6106-81-6]; Down 200; 10uM; HL60; HG-U133A	DENND4A ALMS1 PPP1R12A ENTPD6 LBR FRMD4B	1.80e-05	198	63	6	1415_DN
Drug	Amodiaquin dihydrochloride dihydrate [6398-98-7]; Down 200; 8.6uM; MCF7; HT_HG-U133A	NCOR1 UBAP2L EMD GRSF1 FBXW11 SOS1	1.80e-05	198	63	6	6224_DN
Drug	wortmannin; Down 200; 0.01uM; HL60; HG-U133A	PRR14 IL17A PITRM1 DSG3 TJP1 ADCY1	1.86e-05	199	63	6	389_DN
Drug	AC1L3XQA	DSG3 PPP1R12A ADCY1	1.90e-05	19	63	3	CID000124009
Drug	Acetylsalicylsalicylic acid [530-75-6]; Down 200; 13.4uM; PC3; HT_HG-U133A	RBL2 PPP1R12A SMARCC1 AGMAT SMARCC2 RPRD2	1.91e-05	200	63	6	2061_DN
Drug	Bvpam	DSG3 PPP1R12A DMD	2.59e-05	21	63	3	CID000125185
Disease	Syndactyly Cenani Lenz type	APC LRP4	4.63e-06	2	64	2	C1859309
Disease	Adenocarcinoma of lung (disorder)	APC SMARCC1 PRKDC RRM1 SOS1	8.62e-05	206	64	5	C0152013
Disease	Polydactyly	ALMS1 INPP5E LRP4 LBR	1.24e-04	117	64	4	C0152427
Disease	Celiac Disease	CAPN8 MAGI2 ASAH2	1.47e-04	47	64	3	C0007570
Disease	opportunistic bacterial infectious disease (implicated_via_orthology)	SMARCC1 SMARCC2	1.65e-04	9	64	2	DOID:0050340 (implicated_via_orthology)
Disease	Coffin-Siris syndrome (implicated_via_orthology)	SMARCC1 SMARCC2	1.65e-04	9	64	2	DOID:1925 (implicated_via_orthology)
Disease	Cardiomyopathies	ACTN2 EMD DMD SOS1	1.86e-04	130	64	4	C0878544
Disease	Intellectual Disability	PITRM1 INPP5E PPP1R12A APC SMARCC2 FBXW11	4.17e-04	447	64	6	C3714756
Disease	electroencephalogram measurement	DMD FRMD4B SH3BP4	5.65e-04	74	64	3	EFO_0004357
Disease	respiratory syncytial virus infectious disease (is_marker_for)	IL17A IL5RA	6.93e-04	18	64	2	DOID:1273 (is_marker_for)
Disease	Adrenocortical carcinoma	RRM1 MED12	6.93e-04	18	64	2	C0206686
Disease	obsolete Mendelian syndromes with cleft lip/palate	LRRC7 SH3BP4	1.14e-03	23	64	2	MONDO_0015335
Disease	uveitis (biomarker_via_orthology)	TJP1 KCNJ10	1.35e-03	25	64	2	DOID:13141 (biomarker_via_orthology)
Disease	retinal degeneration (biomarker_via_orthology)	KCNJ10 DMD	1.69e-03	28	64	2	DOID:8466 (biomarker_via_orthology)
Disease	intellectual disability (is_implicated_in)	CASR DMD	1.94e-03	30	64	2	DOID:1059 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RYNSVRPLATLSYAS	COP1	401	Q8NHY2
IQSYNIRISSSNPYS	ACTN2	586	P35609
YIPQVSYASSSRLLS	CASR	161	P41180
VSSVPDNYRTSNYIY	DPH6	251	Q7L8W6
VTSTSYSQYREKPSI	ALMS1	1281	Q8TCU4
LAYQPSARTSTYVNL	CAPN8	456	A6NHC0
YTQAAYVTTSDPTRS	DMD	301	P11532
RTEPINTTYSYTDFQ	DCAF16	191	Q9NXF7
SYEQRQRSASRYFST	ATG2B	586	Q96BY7
ETLQYFSTVDPNYRS	ATG2B	1021	Q96BY7
TNLTYRIRNYTPQLS	MMP8	111	P22894
ISGSTSSQRIYITYR	DENND4A	131	Q7Z401
AVPTRSYSQESKTTY	GRSF1	111	Q12849
SQESSYIATQYSLRP	LBR	156	Q14739
YRTQPQARSQVYRSV	RBL2	916	Q08999
VSARTLNNRYTGPYT	DSG3	511	P32926
QSSTVSTTEAEPYYR	NPHS1	1126	O60500
TYLEYISRTSQSVPD	MAGI2	546	Q86UL8
KVYYSQTTQTESRPL	KCNJ10	6	P78508
QDVTYFVAYQSSPTR	IFNLR1	51	Q8IU57
TSKQRTPSYTDRVLY	INPP5E	546	Q9NRR6
QRRPLSARSYSTESY	LRRC7	1196	Q96NW7
SYLQNPQSERARYSS	ASAH2	261	Q9NR71
LSYPRIVSSSSLQQY	BEND2	206	Q8NDZ0
AQNETRSPSRTYTYI	FBXW11	526	Q9UKB1
YSSQDPNSRSRFYTV	NSG2	121	Q9Y328
PNSRSRFYTVISHYS	NSG2	126	Q9Y328
TNYTVRLELPQYTSS	LAMB1	676	P07942
SSYKTSVYRQQQPAV	MED12	1891	Q93074
TNTNPKRSSDYYNRS	IL17A	56	Q16552
VTGPYYTTQTLDTRT	FRMD4B	746	Q9Y2L6
VVYTTPGTRVNRYIS	ADCY1	556	Q08828
TNTTEDNYSRLRSYQ	IL5RA	136	Q01344
VSVATTYRQYPLSSR	DMRT2	326	Q9Y5R5
YNYDSSSRPQSRSVM	GBA2	736	Q9HCG7
YQSITHYRPVSASRS	EMD	161	P50402
SSTISPYYRQSLFRT	CRYAA	41	P02489
ESYPRELSNSVSTYR	RPRD2	776	Q5VT52
IVSASYSDPYISQRL	OR5D13	186	Q8NGL4
GRYESDVRNTVTYTS	PNPLA8	661	Q9NP80
SSYVQPLNYRNSTLS	SH3BP4	106	Q9P0V3
RYETSRKTSYIFQQP	ENTPD6	6	O75354
YDDTSARRTPVSYQN	NCOR1	1476	O75376
YTNKNYQSPTTRRTF	PRR14	481	Q9BWN1
YSYRDPNTIETLQSF	PITRM1	921	Q5JRX3
GSSTTLDPYRYNRSQ	AGMAT	226	Q9BSE5
TQQRESGYYSSPERS	NUAK1	471	O60285
AYSPRYSISDRTSIS	SOS1	1191	Q07889
DTYRLNPQEYLTSTA	SMARCC1	496	Q92922
DTYRLNPQEYLTSTA	SMARCC2	471	Q8TAQ2
RQSRNQSTTYPVYTE	APC	1066	P25054
VLYSSTSTYIAQDPR	SLC35F1	351	Q5T1Q4
ALTDRTSRAPSTYTY	RSPH3	146	Q86UC2
YIYVRTSGSSSQRDV	ZNF77	46	Q15935
LYEQRSTQTRRYPSS	UBAP2L	591	Q14157
SIEPYTSNIYTRRVL	RRM1	616	P23921
QQLSRIYPSSYRVDS	PLCH2	676	O75038
STGVQSYSYSSQDPR	PRKDC	2046	P78527
SRDLEQPTYRYESSS	TJP1	1051	Q07157
YSPQRTYRSEVSSPI	PLEKHA5	556	Q9HAU0
SDQRQSITSSYKYPE	TGM7	436	Q96PF1
DTRTQTTVQLTIYYP	VSIG10L2	316	P0DP72
RSSPLYEYIQEQRSQ	TCHH	1926	Q07283
LTYRYDDQTSRNTRS	ADAMTSL3	56	P82987
NLTYSNPSYRTSTQE	LRP4	1761	O75096
TYDETYQRYRPVSTS	PPP1R12A	761	O14974