Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	NADPH oxidase complex	NCF4 NOX1	3.21e-04	18	31	2	GO:0043020
Domain	DnaJ_domain_CS	DNAJC5 DNAJC5B	9.12e-04	27	31	2	IPR018253
Domain	ER_TARGET	HSP90B1 POGLUT1	2.75e-03	47	31	2	PS00014
Domain	DnaJ	DNAJC5 DNAJC5B	2.87e-03	48	31	2	PF00226
Domain	DnaJ	DNAJC5 DNAJC5B	2.99e-03	49	31	2	SM00271
Domain	DNAJ_1	DNAJC5 DNAJC5B	2.99e-03	49	31	2	PS00636
Domain	DNAJ_2	DNAJC5 DNAJC5B	2.99e-03	49	31	2	PS50076
Domain	-	DNAJC5 DNAJC5B	2.99e-03	49	31	2	1.10.287.110
Domain	DnaJ_domain	DNAJC5 DNAJC5B	3.23e-03	51	31	2	IPR001623
Domain	-	NRDE2 TMTC1 PPP5C	4.80e-03	207	31	3	1.25.40.10
Domain	PH	DGKH RASA2 TRIO	6.35e-03	229	31	3	PF00169
Domain	DEAD	ASCC3 DDX54	6.51e-03	73	31	2	PF00270
Domain	DEAD/DEAH_box_helicase_dom	ASCC3 DDX54	6.51e-03	73	31	2	IPR011545
Domain	TPR-like_helical_dom	NRDE2 TMTC1 PPP5C	6.66e-03	233	31	3	IPR011990
Domain	TPR_1	TMTC1 PPP5C	9.75e-03	90	31	2	PF00515
Domain	TPR_1	TMTC1 PPP5C	9.75e-03	90	31	2	IPR001440
Domain	PH	DGKH RASA2 TRIO	1.08e-02	278	31	3	SM00233
Domain	PH_DOMAIN	DGKH RASA2 TRIO	1.09e-02	279	31	3	PS50003
Domain	PH_domain	DGKH RASA2 TRIO	1.10e-02	280	31	3	IPR001849
Domain	Helicase_C	ASCC3 DDX54	1.36e-02	107	31	2	PF00271
Domain	HELICc	ASCC3 DDX54	1.36e-02	107	31	2	SM00490
Domain	Helicase_C	ASCC3 DDX54	1.38e-02	108	31	2	IPR001650
Domain	HELICASE_CTER	ASCC3 DDX54	1.41e-02	109	31	2	PS51194
Domain	HELICASE_ATP_BIND_1	ASCC3 DDX54	1.41e-02	109	31	2	PS51192
Pubmed	Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing.	NCF4 NOX1	7.69e-07	2	31	2	16880254
Pubmed	The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis.	NCF4 NOX1	2.31e-06	3	31	2	16880255
Pubmed	Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury.	HSP90B1 NOX1	1.15e-05	6	31	2	20224597
Pubmed	Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox.	HSP90B1 MERTK	1.61e-05	7	31	2	16288044
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	IFI44 IRF2BPL HSP90B1 QSER1 DDX54	2.93e-05	410	31	5	26949251
Pubmed	A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins.	HSP90B1 POGLUT1	6.95e-05	14	31	2	12475965
Pubmed	DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.	CP DROSHA	6.95e-05	14	31	2	21297615
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	HSP90B1 ASCC3 NAB1 DDX54	2.76e-04	357	31	4	37059091
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DGKH POGLUT1 QSER1 RASA2 TRIO ZRANB1 UVSSA	2.77e-04	1489	31	7	28611215
Pubmed	SARS-CoV-2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid droplets.	HSP90B1 ASCC3	3.29e-04	30	31	2	34780058
Pubmed	Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.	TRIO DROSHA	3.29e-04	30	31	2	20083228
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	NRDE2 HSP90B1 ASCC3 RASA2 DDX54	3.61e-04	701	31	5	30196744
Pubmed	Joint influence of small-effect genetic variants on human longevity.	NRDE2 UVSSA	4.24e-04	34	31	2	20834067
Cytoband	11p13	APIP QSER1	6.64e-04	56	31	2	11p13
Cytoband	Ensembl 112 genes in cytogenetic band chr6q16	PRDM13 ASCC3	6.64e-04	56	31	2	chr6q16
Cytoband	Ensembl 112 genes in cytogenetic band chr11p13	APIP QSER1	8.94e-04	65	31	2	chr11p13
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJC5 DNAJC5B	1.33e-03	49	20	2	584
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TMTC1 PPP5C	7.07e-03	115	20	2	769
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	MERTK TRIO	1.35e-02	161	20	2	593
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	DGKH RASA2	2.15e-02	206	20	2	682
Computational	Genes in the cancer module 138.	CP PPP5C TRIO	3.21e-04	87	17	3	MODULE_138
Computational	Genes in the cancer module 174.	CP PPP5C TRIO	4.16e-04	95	17	3	MODULE_174
Drug	p-tolunitrile	CP DROSHA	5.38e-06	3	31	2	CID000007724
Drug	17-AAG; Up 200; 1uM; PC3; HT_HG-U133A	IFI44 QSER1 NOX1 MERTK TRIO	6.36e-06	196	31	5	5919_UP
Drug	biphenylene	IFI44 NCF4 NOX1	1.33e-05	34	31	3	CID000009214
Drug	diphenylketene	CP DROSHA	1.79e-05	5	31	2	CID000123069
Disease	neuronal ceroid lipofuscinosis 4 (implicated_via_orthology)	DNAJC5 DNAJC5B	9.99e-07	2	30	2	DOID:0110720 (implicated_via_orthology)
Disease	neuronal ceroid lipofuscinosis (implicated_via_orthology)	DNAJC5 DNAJC5B	9.02e-05	14	30	2	DOID:14503 (implicated_via_orthology)
Disease	longevity	PRDM13 NRDE2 UVSSA NAB1	1.89e-04	284	30	4	EFO_0004300
Disease	blood urea nitrogen measurement	DGKH ASCC3 DNAJC5B ZRANB1	1.09e-03	452	30	4	EFO_0004741
Disease	eosinophil count	NCF4 DGKH PPP5C RASA2 DNAJC5B ZRANB1	3.40e-03	1488	30	6	EFO_0004842
Disease	Precancerous Conditions	TRIO DDX54	5.60e-03	110	30	2	C0032927
Disease	Condition, Preneoplastic	TRIO DDX54	5.60e-03	110	30	2	C0282313

Protein segments in the cluster

Peptide	Gene	Start	Entry
QYYEKKYGGRSIRKD	ABCA5	1226	Q8WWZ7
SKKKFVGRSKYGRYG	ARSH	276	Q5FYA8
KRSIYDKYGSLGLYV	DNAJC5B	76	Q9UF47
EKYRKKRSSSAKYGS	RASA2	826	Q15283
YLGYFGDAKSKYKRI	QSER1	1411	Q2KHR3
IGGSYKKLVYREYTD	CP	416	P00450
ADKYYYTRKILGSTL	NOX1	36	Q9Y5S8
YSKFLSYNVTRRKGY	POGLUT1	366	Q8NBL1
KKIYSGDYYRQGRIA	MERTK	746	Q12866
KYSAIYGRFDSKRKD	NAB1	251	Q13506
GRYISSSYKRDLYQK	DDX54	756	Q8TDD1
RGLSSGFKYLEYEKK	IRF2BPL	451	Q9H1B7
YKSLYRGDIARYKRK	NRDE2	176	Q9H7Z3
KTKGGSKYLIYRRYR	NCF4	46	Q15080
TKRNIYDKYGSLGLY	DNAJC5	71	Q9H3Z4
YFKLRGRTLYYAKDS	DGKH	86	Q86XP1
YGSKKSDYIKLYVRR	HSP90B1	401	P14625
YRTYSIRDGKDGKYL	IFI44	231	Q8TCB0
YYYRRDIVRKSGGRK	ETV2	301	O00321
LYCGKLYSRKYGLKI	PRDM13	576	Q9H4Q3
IKGIKKCTSGGYYRY	APIP	141	Q96GX9
SYKKEYKRSGRSYGL	DROSHA	306	Q9NRR4
SSRYSGKGRGKKRRY	UVSSA	641	Q2YD98
LDKKYIKGYYRRAAS	PPP5C	91	P53041
VIKTRYESGKYGYES	SLC25A38	146	Q96DW6
IIKGTEYYDGKTRRY	ASCC3	1661	Q8N3C0
YGKGKSCYYRFLTKG	CLOCK	331	O15516
AYKRREYGKSLNSKY	ZNF549	246	Q6P9A3
KGKYVSARAYYERAL	TMTC1	836	Q8IUR5
GVKYYKSFRGETLGY	ZRANB1	541	Q9UGI0
SGRSKYLYKSKLFTS	TRIO	1526	O75962