Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GRIA1 GRIA2 GABRA5	3.90e-06	24	26	3	GO:0099507
GeneOntologyMolecularFunction	AMPA glutamate receptor activity	GRIA1 GRIA2	9.77e-06	4	26	2	GO:0004971
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	GRIA1 GRIA2 GABRA5	5.47e-05	57	26	3	GO:1904315
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	GRIA1 GRIA2 GABRA5	6.38e-05	60	26	3	GO:0099529
GeneOntologyMolecularFunction	transmitter-gated channel activity	GRIA1 GRIA2 GABRA5	8.11e-05	65	26	3	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	GRIA1 GRIA2 GABRA5	8.11e-05	65	26	3	GO:0022824
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	GRIA1 GRIA2 GABRA5	1.24e-04	75	26	3	GO:0098960
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	GRIA1 GRIA2 GABRA5	1.34e-04	77	26	3	GO:0005230
GeneOntologyMolecularFunction	adenylate cyclase binding	GRIA1 AKAP12	1.93e-04	16	26	2	GO:0008179
GeneOntologyMolecularFunction	glutamate-gated receptor activity	GRIA1 GRIA2	2.19e-04	17	26	2	GO:0004970
GeneOntologyMolecularFunction	neurotransmitter receptor activity	GRIA1 GRIA2 GABRA5	2.91e-04	100	26	3	GO:0030594
GeneOntologyMolecularFunction	glutamate receptor activity	GRIA1 GRIA2	5.61e-04	27	26	2	GO:0008066
GeneOntologyMolecularFunction	immunoglobulin binding	GRIA1 GRIA2	9.99e-04	36	26	2	GO:0019865
GeneOntologyMolecularFunction	G-protein alpha-subunit binding	GRIA1 SASH1	1.42e-03	43	26	2	GO:0001965
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	GRIA1 GRIA2 GABRA5	1.96e-03	193	26	3	GO:0015276
GeneOntologyMolecularFunction	ionotropic glutamate receptor binding	GRIA1 GRIA2	2.08e-03	52	26	2	GO:0035255
GeneOntologyMolecularFunction	ligand-gated channel activity	GRIA1 GRIA2 GABRA5	2.08e-03	197	26	3	GO:0022834
GeneOntologyMolecularFunction	cytoskeletal protein binding	GRIA1 GRIA2 HAUS6 PHACTR4 MPRIP MYBPC2	2.44e-03	1099	26	6	GO:0008092
GeneOntologyMolecularFunction	protein kinase A binding	GRIA1 AKAP12	2.58e-03	58	26	2	GO:0051018
GeneOntologyMolecularFunction	glutamate receptor binding	GRIA1 GRIA2	4.96e-03	81	26	2	GO:0035254
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	GRIA1 GRIA2 SLC33A1	6.33e-03	293	26	3	GO:0008514
GeneOntologyMolecularFunction	scaffold protein binding	GRIA1 GRIA2	6.49e-03	93	26	2	GO:0097110
GeneOntologyMolecularFunction	amyloid-beta binding	GRIA1 GRIA2	7.75e-03	102	26	2	GO:0001540
GeneOntologyMolecularFunction	amino acid transmembrane transporter activity	GRIA1 GRIA2	8.20e-03	105	26	2	GO:0015171
GeneOntologyMolecularFunction	gated channel activity	GRIA1 GRIA2 GABRA5	9.07e-03	334	26	3	GO:0022836
GeneOntologyMolecularFunction	phosphatase regulator activity	SBF2 PHACTR4	9.44e-03	113	26	2	GO:0019208
GeneOntologyCellularComponent	perisynaptic space	GRIA1 GRIA2	8.23e-06	4	25	2	GO:0099544
GeneOntologyCellularComponent	dendrite membrane	GRIA1 GRIA2 GABRA5	4.02e-05	56	25	3	GO:0032590
GeneOntologyCellularComponent	neuron projection membrane	GRIA1 GRIA2 GABRA5	1.26e-04	82	25	3	GO:0032589
GeneOntologyCellularComponent	AMPA glutamate receptor complex	GRIA1 GRIA2	5.85e-04	30	25	2	GO:0032281
GeneOntologyCellularComponent	neuronal cell body membrane	GRIA1 GABRA5	1.20e-03	43	25	2	GO:0032809
GeneOntologyCellularComponent	ionotropic glutamate receptor complex	GRIA1 GRIA2	1.32e-03	45	25	2	GO:0008328
GeneOntologyCellularComponent	cell body membrane	GRIA1 GABRA5	1.44e-03	47	25	2	GO:0044298
GeneOntologyCellularComponent	neurotransmitter receptor complex	GRIA1 GRIA2	1.62e-03	50	25	2	GO:0098878
GeneOntologyCellularComponent	postsynaptic specialization membrane	GRIA1 GRIA2 GABRA5	1.72e-03	201	25	3	GO:0099634
GeneOntologyCellularComponent	leading edge membrane	GRIA1 GRIA2 GABRA5	1.95e-03	210	25	3	GO:0031256
GeneOntologyCellularComponent	cell leading edge	GRIA1 GRIA2 PHACTR4 GABRA5	2.74e-03	500	25	4	GO:0031252
GeneOntologyCellularComponent	dendritic shaft	GRIA1 GRIA2	3.52e-03	74	25	2	GO:0043198
GeneOntologyCellularComponent	presynaptic active zone membrane	GRIA1 GRIA2	3.90e-03	78	25	2	GO:0048787
GeneOntologyCellularComponent	presynaptic membrane	GRIA1 GRIA2 GABRA5	4.27e-03	277	25	3	GO:0042734
GeneOntologyCellularComponent	receptor complex	GRIA1 GRIA2 OLR1 GABRA5	4.70e-03	581	25	4	GO:0043235
Domain	Iontro_rcpt	GRIA1 GRIA2	2.81e-04	18	26	2	IPR001320
Domain	Lig_chan	GRIA1 GRIA2	2.81e-04	18	26	2	PF00060
Domain	Lig_chan-Glu_bd	GRIA1 GRIA2	2.81e-04	18	26	2	PF10613
Domain	PBPe	GRIA1 GRIA2	2.81e-04	18	26	2	SM00079
Domain	Iono_rcpt_met	GRIA1 GRIA2	2.81e-04	18	26	2	IPR001508
Domain	Glu/Gly-bd	GRIA1 GRIA2	2.81e-04	18	26	2	IPR019594
Domain	Lig_chan-Glu_bd	GRIA1 GRIA2	2.81e-04	18	26	2	SM00918
Domain	ANF_receptor	GRIA1 GRIA2	1.20e-03	37	26	2	PF01094
Domain	ANF_lig-bd_rcpt	GRIA1 GRIA2	1.20e-03	37	26	2	IPR001828
Domain	Peripla_BP_I	GRIA1 GRIA2	1.34e-03	39	26	2	IPR028082
Pathway	REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS	GRIA1 GRIA2	2.04e-04	16	19	2	MM15048
Pathway	REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS	GRIA1 GRIA2	2.31e-04	17	19	2	M5488
Pathway	WP_NRXN1_DELETION_SYNDROME	GRIA1 GRIA2	2.60e-04	18	19	2	M48098
Pathway	REACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION	GRIA1 GRIA2	3.56e-04	21	19	2	M838
Pathway	WP_PKCGAMMA_CALCIUM_SIGNALING_IN_ATAXIA	GRIA1 GRIA2	3.91e-04	22	19	2	M39795
Pathway	REACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION	GRIA1 GRIA2	3.91e-04	22	19	2	MM15104
Pathway	REACTOME_LONG_TERM_POTENTIATION	GRIA1 GRIA2	4.28e-04	23	19	2	M27949
Pathway	REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS	GRIA1 GRIA2	6.84e-04	29	19	2	MM15028
Pathway	REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS	GRIA1 GRIA2	7.82e-04	31	19	2	M7223
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	GRIA1 GRIA2 GABRA5	8.97e-04	144	19	3	MM14501
Pathway	REACTOME_NEURONAL_SYSTEM	GRIA1 GRIA2 IL1RAP GABRA5	9.15e-04	335	19	4	MM14503
Pathway	REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS	GRIA1 GRIA2	9.97e-04	35	19	2	MM15109
Pathway	WP_COMMON_PATHWAYS_UNDERLYING_DRUG_ADDICTION	GRIA1 GRIA2	1.37e-03	41	19	2	M39655
Pathway	REACTOME_NEURONAL_SYSTEM	GRIA1 GRIA2 IL1RAP GABRA5	1.95e-03	411	19	4	M735
Pathway	KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS	GRIA1 GRIA2	2.28e-03	53	19	2	M3812
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	GRIA1 GRIA2 GABRA5	2.47e-03	205	19	3	M752
Pathway	REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	GRIA1 GRIA2 GABRA5	2.68e-03	211	19	3	MM14502
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	GRIA1 IL1RAP	3.61e-03	67	19	2	MM15327
Pathway	WP_PPAR_SIGNALING	OLR1 PCK1	3.61e-03	67	19	2	M39553
Pathway	KEGG_PPAR_SIGNALING_PATHWAY	OLR1 PCK1	3.83e-03	69	19	2	M13088
Pathway	KEGG_LONG_TERM_POTENTIATION	GRIA1 GRIA2	3.94e-03	70	19	2	M3115
Pathway	KEGG_LONG_TERM_DEPRESSION	GRIA1 GRIA2	3.94e-03	70	19	2	M8232
Pubmed	Involvement of AMPA receptor GluR2 subunits in stimulus-reward learning: evidence from glutamate receptor gria2 knock-out mice.	GRIA1 GRIA2	5.37e-07	2	26	2	14573529
Pubmed	AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus.	GRIA1 GRIA2	5.37e-07	2	26	2	7919190
Pubmed	A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-A.	GRIA1 GRIA2	5.37e-07	2	26	2	14555717
Pubmed	Different Forms of AMPA Receptor Mediated LTP and Their Correlation to the Spatial Working Memory Formation.	GRIA1 GRIA2	5.37e-07	2	26	2	28725178
Pubmed	AMPA receptor regulation during synaptic plasticity in hippocampus and neocortex.	GRIA1 GRIA2	5.37e-07	2	26	2	21856433
Pubmed	Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors.	GRIA1 GRIA2	5.37e-07	2	26	2	31053408
Pubmed	AMPAR trafficking in synapse maturation and plasticity.	GRIA1 GRIA2	5.37e-07	2	26	2	23475111
Pubmed	Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice.	GRIA1 GRIA2	5.37e-07	2	26	2	7502080
Pubmed	Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors.	GRIA1 GRIA2	5.37e-07	2	26	2	1311100
Pubmed	Expression of alternatively-spliced glutamate receptors in human hippocampus.	GRIA1 GRIA2	5.37e-07	2	26	2	8420792
Pubmed	New insights in endosomal dynamics and AMPA receptor trafficking.	GRIA1 GRIA2	5.37e-07	2	26	2	21843653
Pubmed	Reactive oxygen species (ROS) modulate AMPA receptor phosphorylation and cell-surface localization in concert with pain-related behavior.	GRIA1 GRIA2	5.37e-07	2	26	2	22770842
Pubmed	Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate.	GRIA1 GRIA2	5.37e-07	2	26	2	1699805
Pubmed	GluA2-lacking AMPA receptors in hippocampal CA1 cell synapses: evidence from gene-targeted mice.	GRIA1 GRIA2	5.37e-07	2	26	2	22375105
Pubmed	Human Autoantibodies against the AMPA Receptor Subunit GluA2 Induce Receptor Reorganization and Memory Dysfunction.	GRIA1 GRIA2	5.37e-07	2	26	2	30146304
Pubmed	The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice.	GRIA1 GRIA2	5.37e-07	2	26	2	34924114
Pubmed	The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning.	GRIA1 GRIA2	5.37e-07	2	26	2	29230056
Pubmed	Effects of deletion of gria1 or gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in mice.	GRIA1 GRIA2	5.37e-07	2	26	2	15619119
Pubmed	Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice.	GRIA1 GRIA2	5.37e-07	2	26	2	21383497
Pubmed	Altered AMPA receptor expression with treadmill exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury.	GRIA1 GRIA2	5.37e-07	2	26	2	19746427
Pubmed	The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain.	GRIA1 GRIA2	5.37e-07	2	26	2	15541312
Pubmed	Cortical Synaptic AMPA Receptor Plasticity during Motor Learning.	GRIA1 GRIA2	5.37e-07	2	26	2	31901303
Pubmed	Chronic stress-induced dendritic reorganization and abundance of synaptosomal PKA-dependent CP-AMPA receptor in the basolateral amygdala in a mouse model of depression.	GRIA1 GRIA2	5.37e-07	2	26	2	28336441
Pubmed	Synaptic AMPA receptor exchange maintains bidirectional plasticity.	GRIA1 GRIA2	5.37e-07	2	26	2	16600857
Pubmed	NMDAR-dependent presynaptic homeostasis in adult hippocampus: Synapse growth and cross-modal inhibitory plasticity.	GRIA1 GRIA2	1.61e-06	3	26	2	36070750
Pubmed	Neural mechanism underlies CYLD modulation of morphology and synaptic function of medium spiny neurons in dorsolateral striatum.	GRIA1 GRIA2	1.61e-06	3	26	2	36846565
Pubmed	Differential preservation of AMPA receptor subunits in the hippocampi of Alzheimer's disease patients according to Braak stage.	GRIA1 GRIA2	1.61e-06	3	26	2	15144856
Pubmed	Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome.	GRIA1 GRIA2	1.61e-06	3	26	2	17507556
Pubmed	VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation.	GRIA1 GRIA2	1.61e-06	3	26	2	26521016
Pubmed	Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to antipsychotic treatment in patients with schizophrenia.	GRIA1 GRIA2	1.61e-06	3	26	2	22094384
Pubmed	The role of the AMPA receptor and 5-HT(3) receptor on aggressive behavior and depressive-like symptoms in chronic social isolation-reared mice.	GRIA1 GRIA2	1.61e-06	3	26	2	26522741
Pubmed	Case-control association study of GRIA1, GRIA2 and GRIA4 polymorphisms in bipolar disorder.	GRIA1 GRIA2	1.61e-06	3	26	2	22122651
Pubmed	Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington's disease models.	GRIA1 GRIA2	1.61e-06	3	26	2	30323233
Pubmed	Different domains of the AMPA receptor direct stargazin-mediated trafficking and stargazin-mediated modulation of kinetics.	GRIA1 GRIA2	1.61e-06	3	26	2	16793768
Pubmed	An inhalation anaesthesia approach for neonatal mice allowing streamlined stereotactic injection in the brain.	GRIA1 GRIA2	1.61e-06	3	26	2	32569783
Pubmed	Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex.	GRIA1 GRIA2	1.61e-06	3	26	2	36223737
Pubmed	Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach.	GRIA1 GRIA2	1.61e-06	3	26	2	19409270
Pubmed	Persistent synaptic scaling independent of AMPA receptor subunit composition.	GRIA1 GRIA2	1.61e-06	3	26	2	23864664
Pubmed	Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by gamma-secretase.	GRIA1 GRIA2	1.61e-06	3	26	2	12700243
Pubmed	Synaptic targeting of AMPA receptors is regulated by a CaMKII site in the first intracellular loop of GluA1.	GRIA1 GRIA2	1.61e-06	3	26	2	21135237
Pubmed	FXR1P limits long-term memory, long-lasting synaptic potentiation, and de novo GluA2 translation.	GRIA1 GRIA2	1.61e-06	3	26	2	25456134
Pubmed	AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions.	GRIA1 GRIA2	1.61e-06	3	26	2	34426577
Pubmed	AMPA receptor alterations precede mossy fiber sprouting in young children with temporal lobe epilepsy.	GRIA1 GRIA2	1.61e-06	3	26	2	15145077
Pubmed	Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to treatment in patients with major depressive disorder.	GRIA1 GRIA2	1.61e-06	3	26	2	22057216
Pubmed	Synaptic transmission and plasticity require AMPA receptor anchoring via its N-terminal domain.	GRIA1 GRIA2	1.61e-06	3	26	2	28290985
Pubmed	Potentiation of synaptic AMPA receptors induced by the deletion of NMDA receptors requires the GluA2 subunit.	GRIA1 GRIA2	1.61e-06	3	26	2	20980546
Pubmed	Subunit-specific role for the amino-terminal domain of AMPA receptors in synaptic targeting.	GRIA1 GRIA2	1.61e-06	3	26	2	28630296
Pubmed	Long-term upregulation of cortical glutamatergic AMPA receptors in a mouse model of chronic visceral pain.	GRIA1 GRIA2	1.61e-06	3	26	2	26585043
Pubmed	Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors.	GRIA1 GRIA2	1.61e-06	3	26	2	14687553
Pubmed	LTP requires a reserve pool of glutamate receptors independent of subunit type.	GRIA1 GRIA2	1.61e-06	3	26	2	23235828
Pubmed	Synaptic homeostasis requires the membrane-proximal carboxy tail of GluA2.	GRIA1 GRIA2	1.61e-06	3	26	2	29180434
Pubmed	Subtype-specific assembly of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits is mediated by their n-terminal domains.	GRIA1 GRIA2	1.61e-06	3	26	2	10358037
Pubmed	Tumor necrosis-factor-alpha (TNF-alpha) induces rapid insertion of Ca2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons.	GRIA1 GRIA2	1.61e-06	3	26	2	15869941
Pubmed	Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains.	GRIA1 GRIA2	1.61e-06	3	26	2	29706584
Pubmed	The N-terminal domain modulates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor desensitization.	GRIA1 GRIA2	3.22e-06	4	26	2	24652293
Pubmed	Electrophysiological properties of AMPA receptors are differentially modulated depending on the associated member of the TARP family.	GRIA1 GRIA2	3.22e-06	4	26	2	17409242
Pubmed	Gating and modulation of a hetero-octameric AMPA glutamate receptor.	GRIA1 GRIA2	3.22e-06	4	26	2	34079129
Pubmed	Reduced levels of the tyrosine phosphatase STEP block β amyloid-mediated GluA1/GluA2 receptor internalization.	GRIA1 GRIA2	3.22e-06	4	26	2	21883219
Pubmed	The cell-autonomous role of excitatory synaptic transmission in the regulation of neuronal structure and function.	GRIA1 GRIA2	3.22e-06	4	26	2	23664612
Pubmed	A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing.	GRIA1 GRIA2	3.22e-06	4	26	2	10688364
Pubmed	Cortactin regulates endo-lysosomal sorting of AMPARs via direct interaction with GluA2 subunit.	GRIA1 GRIA2	3.22e-06	4	26	2	29515177
Pubmed	Chromosomal localization of human glutamate receptor genes.	GRIA1 GRIA2	3.22e-06	4	26	2	1319477
Pubmed	Altered presymptomatic AMPA and cannabinoid receptor trafficking in motor neurons of ALS model mice: implications for excitotoxicity.	GRIA1 GRIA2	3.22e-06	4	26	2	18279310
Pubmed	The Role of AMPARs in the Maturation and Integration of Caudal Ganglionic Eminence-Derived Interneurons into Developing Hippocampal Microcircuits.	GRIA1 GRIA2	3.22e-06	4	26	2	30931998
Pubmed	AMPA receptors regulate dynamic equilibrium of presynaptic terminals in mature hippocampal networks.	GRIA1 GRIA2	3.22e-06	4	26	2	12692557
Pubmed	AMPA receptor deletion in developing MGE-derived hippocampal interneurons causes a redistribution of excitatory synapses and attenuates postnatal network oscillatory activity.	GRIA1 GRIA2	3.22e-06	4	26	2	31992779
Pubmed	LARGE, an intellectual disability-associated protein, regulates AMPA-type glutamate receptor trafficking and memory.	GRIA1 GRIA2	3.22e-06	4	26	2	29915039
Pubmed	GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons.	GRIA1 GRIA2	3.22e-06	4	26	2	26932439
Pubmed	Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis.	GRIA1 GRIA2	3.22e-06	4	26	2	12125045
Pubmed	LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes.	GRIA1 GRIA2	3.22e-06	4	26	2	29581259
Pubmed	AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62.	GRIA1 GRIA2	3.22e-06	4	26	2	19004011
Pubmed	Distribution of alpha-amino-3-hydroxy-5-methyl-4 isoazolepropionic acid and N-methyl-D-aspartate receptor subunits in the vestibular and spiral ganglia of the mouse during early development.	GRIA1 GRIA2	3.22e-06	4	26	2	12414093
Pubmed	Glutamate receptors on dopamine neurons control the persistence of cocaine seeking.	GRIA1 GRIA2	3.22e-06	4	26	2	18701074
Pubmed	AMPA receptor subunits expressed by single astrocytes in the juvenile mouse hippocampus.	GRIA1 GRIA2	3.22e-06	4	26	2	9221927
Pubmed	Tumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit: relevance to neurodegeneration.	GRIA1 GRIA2	3.22e-06	4	26	2	20132465
Pubmed	Interaction proteomics reveals brain region-specific AMPA receptor complexes.	GRIA1 GRIA2	3.22e-06	4	26	2	25337787
Pubmed	Age-dependent requirement of AKAP150-anchored PKA and GluR2-lacking AMPA receptors in LTP.	GRIA1 GRIA2	3.22e-06	4	26	2	17972919
Pubmed	Aberrant formation of glutamate receptor complexes in hippocampal neurons of mice lacking the GluR2 AMPA receptor subunit.	GRIA1 GRIA2	3.22e-06	4	26	2	14561864
Pubmed	Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors.	GRIA1 GRIA2	3.22e-06	4	26	2	17828255
Pubmed	Protein-protein coupling/uncoupling enables dopamine D2 receptor regulation of AMPA receptor-mediated excitotoxicity.	GRIA1 GRIA2	3.22e-06	4	26	2	15858065
Pubmed	Genetic Deletion of GABAA Receptors Reveals Distinct Requirements of Neurotransmitter Receptors for GABAergic and Glutamatergic Synapse Development.	GRIA1 GRIA2	3.22e-06	4	26	2	31231192
Pubmed	Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit.	GRIA1 GRIA2	3.22e-06	4	26	2	32831170
Pubmed	AMPA receptor-mediated excitotoxicity in human NT2-N neurons results from loss of intracellular Ca2+ homeostasis following marked elevation of intracellular Na+.	GRIA1 GRIA2	3.22e-06	4	26	2	9648857
Pubmed	Changes in subcellular localization of metabotropic glutamate receptor subtypes during postnatal development of mouse thalamus.	GRIA1 GRIA2	3.22e-06	4	26	2	9619499
Pubmed	Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors.	GRIA1 GRIA2	5.37e-06	5	26	2	12573530
Pubmed	Allosteric modulation of AMPA-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, N-CAM.	GRIA1 GRIA2	5.37e-06	5	26	2	9482932
Pubmed	Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.	GRIA1 GRIA2	5.37e-06	5	26	2	24706758
Pubmed	Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies.	GRIA1 GRIA2	5.37e-06	5	26	2	8288598
Pubmed	Phase Separation-Mediated TARP/MAGUK Complex Condensation and AMPA Receptor Synaptic Transmission.	GRIA1 GRIA2	5.37e-06	5	26	2	31492534
Pubmed	RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission.	GRIA1 GRIA2	5.37e-06	5	26	2	36179027
Pubmed	Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites.	GRIA1 GRIA2	5.37e-06	5	26	2	16129400
Pubmed	Ferric Chelate Reductase 1 Like Protein (FRRS1L) Associates with Dynein Vesicles and Regulates Glutamatergic Synaptic Transmission.	GRIA1 GRIA2	8.05e-06	6	26	2	29276473
Pubmed	Proteomics analysis of immuno-precipitated synaptic protein complexes.	GRIA1 GRIA2	8.05e-06	6	26	2	19022416
Pubmed	Genetic regulation of glutamate receptor ion channels.	GRIA1 GRIA2	8.05e-06	6	26	2	10331083
Pubmed	PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover.	GRIA1 GRIA2	8.05e-06	6	26	2	30867511
Pubmed	Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice.	GRIA1 GRIA2	8.05e-06	6	26	2	20418887
Pubmed	Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior.	GRIA1 GRIA2	8.05e-06	6	26	2	28194005
Pubmed	Mossy Cells Control Adult Neural Stem Cell Quiescence and Maintenance through a Dynamic Balance between Direct and Indirect Pathways.	GRIA1 GRIA2	8.05e-06	6	26	2	30057205
Pubmed	Cornichon proteins determine the subunit composition of synaptic AMPA receptors.	GRIA1 GRIA2	8.05e-06	6	26	2	23522044
Pubmed	Vulnerability of white matter towards antenatal hypoxia is linked to a species-dependent regulation of glutamate receptor subunits.	GRIA1 GRIA2	8.05e-06	6	26	2	18922769
Interaction	SHISA9 interactions	GRIA1 GRIA2	2.39e-05	6	26	2	int:SHISA9
Interaction	CPT1C interactions	GRIA1 GRIA2	4.46e-05	8	26	2	int:CPT1C
Cytoband	Ensembl 112 genes in cytogenetic band chr2p25	PDIA6 TAF1B	2.36e-03	127	26	2	chr2p25
GeneFamily	Glutamate ionotropic receptor AMPA type subunits	GRIA1 GRIA2	6.27e-06	4	19	2	1200
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	SBF2 MPRIP	1.94e-02	206	19	2	682
Coexpression	GSE13173_UNTREATED_VS_IL12_TREATED_ACT_CD8_TCELL_DN	HAUS6 SLC33A1 SBF2 PHACTR4	1.09e-05	141	26	4	M465
Coexpression	TGFB_UP.V1_UP	SOCS6 AKAP12 CHST3 MYBPC2	3.46e-05	189	26	4	M2839
Coexpression	GSE19512_NAUTRAL_VS_INDUCED_TREG_DN	PDIA6 OLR1 AKAP12 GABRA5	4.31e-05	200	26	4	M8359
Coexpression	CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3	PDIA6 SASH1 VPS13C KIAA0232 AKAP12 SBF2	6.34e-05	726	26	6	M4210
CoexpressionAtlas	BM Top 100 - amygdala	GRIA1 GRIA2 GABRA5	8.49e-05	73	25	3	BM Top 100 - amygdala
CoexpressionAtlas	BM Top 100 - hippocampus	GRIA1 GRIA2 GABRA5	1.03e-04	78	25	3	BM Top 100 - hippocampus
ToppCell	LPS-antiTNF-Endothelial-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CBX7 TAF1B CHST3	7.91e-05	144	26	3	75b16adfbe84f69376e6566d531ba7919d5c5192
ToppCell	Bronchial-10x5prime-Stromal-Schwann\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IL1RAP TMEM117 CHST3	1.12e-04	162	26	3	afffecc6c504930554aafc12c5bffa53e3c5b016
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	GRIA1 GRIA2 IL1RAP	1.18e-04	165	26	3	9795ce31689bc63f5a2d68725ef00b23a90c3846
ToppCell	facs-Kidney-nan-3m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HAUS6 CHST3 MYBPC2	1.20e-04	166	26	3	6a948aefd283a2572da37b59dbc142b6e686b024
ToppCell	facs-Kidney-nan-3m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HAUS6 CHST3 MYBPC2	1.20e-04	166	26	3	8d0c4eb90a2c006f96ae61d3d94c96fb64bc0c4d
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IL1RAP OLR1 AKAP12	1.23e-04	167	26	3	ecdbfde870a2a44c44b9dd65a8737afc6fbf816c
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GRIA2 AKAP12 GABRA5	1.25e-04	168	26	3	74d6dbf9295933acdee785af9b73a94377d15412
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GRIA1 SASH1 AKAP12	1.46e-04	177	26	3	b1775e05c28883a15c56628028770bc59d3233fb
ToppCell	droplet-Thymus-nan-24m-Myeloid-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CBX7 CHST3 MYBPC2	1.56e-04	181	26	3	2a3092fbadd18967199f1203c11f0dd956417254
ToppCell	droplet-Marrow-nan-3m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VPS13C AKAP12 CHST3	1.58e-04	182	26	3	f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GRIA1 SASH1 AKAP12	1.58e-04	182	26	3	fd786c88826ad3d5cc5c3d80f8e392d6be1b5267
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_3\|390C / Donor, Lineage, Cell class and subclass (all cells)	OTULIN TAF1B PHACTR4	1.61e-04	183	26	3	228092290dbb08785c4eda224e3ad03e99e10fab
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRDM9 AKAP12 CHST3	1.61e-04	183	26	3	bc24145855bf4d027a8058bf92bc796c10f241bb
ToppCell	Immune_cells-large_pre-B.\|World / Lineage and Cell class	GRIA2 AKAP12 CHST3	1.61e-04	183	26	3	81b5ed6ed661d2d6a9b807fefd2f0d59bd4ea77e
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRDM9 AKAP12 CHST3	1.61e-04	183	26	3	4c325ee6da070513097a11445ec95b0415ffd8a2
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GRIA1 SASH1 AKAP12	1.63e-04	184	26	3	453295362888c9a59d0e73c7a5b15914c50ff591
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	GRIA2 PCK1 CHST3	1.66e-04	185	26	3	8ed10ba581849c9c4ac4397226be2b62b4b3b900
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VPS13C AKAP12 CHST3	1.66e-04	185	26	3	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	GRIA2 PCK1 CHST3	1.66e-04	185	26	3	b8052cebb73f41abe6faf0aa847be7c8ef23ae94
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_3\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	OTULIN TAF1B PHACTR4	1.71e-04	187	26	3	1eed2c1a05e80a7c8f639437c117afe0c18dfb0c
ToppCell	Control-Endothelial-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SASH1 SBF2 PHACTR4	1.88e-04	193	26	3	aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCell	Control-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SASH1 SBF2 PHACTR4	1.88e-04	193	26	3	c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCell	COPD-Myeloid\|COPD / Disease state, Lineage and Cell class	IL1RAP OLR1 SBF2	1.88e-04	193	26	3	f58552e286aa27e592497ad78776f58f8ee09841
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GRIA2 IL1RAP AKAP12	1.91e-04	194	26	3	08fad7591c20568de797cf8e206de2d0b1d78aab
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	GRIA1 AKAP12 SBF2	1.94e-04	195	26	3	70387a62f121f8c374dba1aca9ab65cfed6a0b10
ToppCell	saliva-Mild-Moderate_progression_d12-25-Epithelial-Epithelial,_Airway-squamous_epithelial_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SASH1 PHACTR4 MPRIP	2.06e-04	199	26	3	2dae9db4d25f1a390134da2b6621564b274fe910
ToppCell	saliva-Mild-Moderate_progression_d12-25-Epithelial\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SASH1 PHACTR4 MPRIP	2.06e-04	199	26	3	dbb33f0e151b150ba9ca4612973f8034c62e762b
ToppCell	saliva-Mild-Moderate_progression_d12-25-Epithelial-Epithelial,_Airway-squamous_epithelial_cell-Epi-Squamous\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SASH1 PHACTR4 MPRIP	2.06e-04	199	26	3	667e1a56c33a2681af8dc1b7dbc3a9858e2c3c05
ToppCell	saliva-Mild-Moderate_progression_d12-25-Epithelial-Epithelial,_Airway\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SASH1 PHACTR4 MPRIP	2.06e-04	199	26	3	245b37df56dfbbdbac88f0e2fc3dfa0ed1abd588
Drug	Phenobarbital	GRIA1 GRIA2 GABRA5	2.17e-07	11	26	3	DB01174
Drug	4-bromohomoibotenic acid	GRIA1 GRIA2	1.25e-06	2	26	2	ctd:C023366
Drug	2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid	GRIA1 GRIA2	1.25e-06	2	26	2	ctd:C474829
Drug	3-isoxazolol	GRIA1 GRIA2	7.51e-06	4	26	2	CID009964065
Drug	sunifiram	GRIA1 GRIA2	7.51e-06	4	26	2	CID004223812
Drug	3-pyridazinol 1-oxide	GRIA1 GRIA2	7.51e-06	4	26	2	CID000574311
Drug	4-(chloromethyl)-3-methoxy-5-methylisoxazole	GRIA1 GRIA2	7.51e-06	4	26	2	CID011105661
Drug	AC1L1YEG	GRIA1 GRIA2	1.25e-05	5	26	2	CID000063114
Drug	Chicago acid	GRIA1 GRIA2	1.25e-05	5	26	2	CID000065740
Drug	irampanel	GRIA1 GRIA2	1.25e-05	5	26	2	CID003038472
Drug	CHEBI:570577	GRIA1 GRIA2	1.25e-05	5	26	2	CID011334126
Drug	beta-N-oxalylaminoalanine	GRIA1 GRIA2	1.25e-05	5	26	2	CID000107978
Drug	LY395153	GRIA1 GRIA2	1.25e-05	5	26	2	CID000656707
Drug	5-h PCA	GRIA1 GRIA2	1.25e-05	5	26	2	CID000129091
Drug	1-BCP	GRIA1 GRIA2	1.25e-05	5	26	2	CID000001370
Drug	saclofen	GRIA1 GRIA2 GABRA5	1.70e-05	44	26	3	CID000122150
Drug	2cmo	GRIA1 GRIA2	1.88e-05	6	26	2	CID006914597
Drug	YM928	GRIA1 GRIA2	1.88e-05	6	26	2	CID006918393
Drug	9-HODE	GRIA1 GRIA2 OLR1 PCK1	1.95e-05	142	26	4	CID000001927
Drug	4,6-dichloroindole-2-carboxylic acid	GRIA1 GRIA2	2.62e-05	7	26	2	CID000127988
Drug	2H-1,2,4-benzothiadiazine	GRIA1 GRIA2	2.62e-05	7	26	2	CID000473368
Drug	thio-ATPA	GRIA1 GRIA2	2.62e-05	7	26	2	CID005289517
Drug	2,3-PDCA	GRIA1 GRIA2	3.50e-05	8	26	2	CID000127037
Drug	1-hydroxyimidazole	GRIA1 GRIA2	3.50e-05	8	26	2	CID003614351
Drug	Iem 1460	GRIA1 GRIA2	3.50e-05	8	26	2	CID003248290
Drug	homoibotenic acid	GRIA1 GRIA2	3.50e-05	8	26	2	CID000194385
Drug	1-hydroxypyrazole	GRIA1 GRIA2	3.50e-05	8	26	2	CID003016733
Drug	SR 95531	GRIA1 GRIA2 GABRA5	4.12e-05	59	26	3	CID000005275
Drug	Ly294486	GRIA1 GRIA2	4.49e-05	9	26	2	CID005311255
Drug	1m5b	GRIA1 GRIA2	4.49e-05	9	26	2	CID000447081
Drug	isothiazol-3-one	GRIA1 GRIA2	4.49e-05	9	26	2	CID000096917
Drug	LY339434	GRIA1 GRIA2	4.49e-05	9	26	2	CID006324635
Drug	AP-7	GRIA1 GRIA2 GABRA5	5.02e-05	63	26	3	CID000003122
Drug	Secobarbital	GRIA2 GABRA5	5.61e-05	10	26	2	DB00418
Drug	Metharbital	GRIA2 GABRA5	5.61e-05	10	26	2	DB00463
Drug	Pentobarbital	GRIA2 GABRA5	5.61e-05	10	26	2	DB00312
Drug	Talbutal	GRIA2 GABRA5	5.61e-05	10	26	2	DB00306
Drug	Butalbital	GRIA2 GABRA5	5.61e-05	10	26	2	DB00241
Drug	Butabarbital	GRIA2 GABRA5	5.61e-05	10	26	2	DB00237
Drug	Barbituric acid derivative	GRIA2 GABRA5	5.61e-05	10	26	2	DB01496
Drug	Barbital	GRIA2 GABRA5	5.61e-05	10	26	2	DB01483
Drug	Methylphenobarbital	GRIA2 GABRA5	5.61e-05	10	26	2	DB00849
Drug	Hexobarbital	GRIA2 GABRA5	5.61e-05	10	26	2	DB01355
Drug	Aprobarbital	GRIA2 GABRA5	5.61e-05	10	26	2	DB01352
Drug	Amobarbital	GRIA2 GABRA5	5.61e-05	10	26	2	DB01351
Drug	Heptabarbital	GRIA2 GABRA5	5.61e-05	10	26	2	DB01354
Drug	Butethal	GRIA2 GABRA5	5.61e-05	10	26	2	DB01353
Drug	Primidone	GRIA2 GABRA5	5.61e-05	10	26	2	DB00794
Drug	Benzoates	GRIA1 GRIA2	5.61e-05	10	26	2	ctd:D001565
Drug	Diphenhydramine hydrochloride [147-24-0]; Up 200; 13.8uM; PC3; HT_HG-U133A	SOCS6 IL1RAP SLC33A1 AKAP12	6.47e-05	193	26	4	1830_UP
Drug	Penicillins	GRIA1 GRIA2	6.85e-05	11	26	2	ctd:D010406
Drug	Thiopental	GRIA2 GABRA5	6.85e-05	11	26	2	DB00599
Drug	J-ST	GRIA1 GRIA2	6.85e-05	11	26	2	CID005288655
Drug	0-ol	GRIA1 GRIA2	6.85e-05	11	26	2	CID000069892
Drug	sym 2206	GRIA1 GRIA2	6.85e-05	11	26	2	CID005039877
Drug	YM872	GRIA1 GRIA2	6.85e-05	11	26	2	CID000148200
Drug	felbamate	GRIA1 GRIA2 GABRA5	6.88e-05	70	26	3	CID000003331
Drug	Phenethicillin potassium salt [132-93-4]; Down 200; 10uM; MCF7; HT_HG-U133A	SOCS6 SLC33A1 AKAP12 PHACTR4	7.14e-05	198	26	4	6239_DN
Drug	PHA-00851261E [724719-49-7]; Down 200; 10uM; MCF7; HT_HG-U133A	SASH1 IL1RAP TAF1B AKAP12	7.14e-05	198	26	4	3854_DN
Drug	C-X6	GRIA1 GRIA2	8.22e-05	12	26	2	CID005288002
Drug	Atpa	GRIA1 GRIA2	8.22e-05	12	26	2	CID000002252
Drug	1NaPP1	GRIA1 GRIA2	8.22e-05	12	26	2	CID000004877
Drug	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	GRIA1 GRIA2	9.71e-05	13	26	2	ctd:D018350
Drug	Naspm	GRIA1 GRIA2	9.71e-05	13	26	2	CID000129695
Drug	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea	GRIA1 GRIA2	9.71e-05	13	26	2	ctd:C479831
Drug	QX-314	GRIA1 GRIA2 GABRA5	1.10e-04	82	26	3	CID000003925
Drug	quinoxaline-2,3-dione	GRIA1 GRIA2	1.13e-04	14	26	2	CID011469229
Drug	DNQX	GRIA1 GRIA2 GABRA5	1.14e-04	83	26	3	CID003899541
Drug	AC1L1B1W	GRIA1 GRIA2 GABRA5	1.18e-04	84	26	3	CID000001248
Drug	D-N-Q	GRIA1 GRIA2 GABRA5	1.18e-04	84	26	3	CID000003140
Drug	NSC759587	GRIA1 GRIA2 IL1RAP OLR1 GABRA5	1.29e-04	444	26	5	CID000003816
Drug	thiokynurenic acid	GRIA1 GRIA2	1.30e-04	15	26	2	CID003035667
Drug	NBQX	GRIA1 GRIA2 GABRA5	1.45e-04	90	26	3	CID003272523
Drug	6-Cyano-7-nitroquinoxaline-2,3-dione	GRIA1 GRIA2	1.49e-04	16	26	2	ctd:D018750
Drug	repinotan	GRIA1 GRIA2	1.49e-04	16	26	2	CID000198756
Drug	LY233536	GRIA1 GRIA2	1.49e-04	16	26	2	CID000126239
Drug	decahydroisoquinoline	GRIA1 GRIA2	1.49e-04	16	26	2	CID000097812
Drug	Dopamine	CBX7 GRIA1 GRIA2 PDIA6	1.50e-04	240	26	4	ctd:D004298
Drug	PPNDS	GRIA1 GRIA2	1.69e-04	17	26	2	CID005961627
Drug	7-Cl-Thio-Kyna	GRIA1 GRIA2	1.69e-04	17	26	2	CID003035668
Drug	MNQX	GRIA1 GRIA2	1.90e-04	18	26	2	CID000130818
Drug	biotinyl-L-lysine	GRIA1 GRIA2 GABRA5	1.93e-04	99	26	3	CID000083814
Drug	AC1Q3ZOL	GRIA1 GRIA2 SOCS6 GABRA5	1.98e-04	258	26	4	CID000002376
Drug	LY382884	GRIA1 GRIA2	2.12e-04	19	26	2	CID000656723
Drug	cyclothiazide	GRIA1 GRIA2 GABRA5	2.17e-04	103	26	3	CID000002910
Drug	IDRA 21	GRIA1 GRIA2	2.35e-04	20	26	2	CID000003688
Drug	AC1N8N2J	GRIA1 GRIA2	2.35e-04	20	26	2	CID004346372
Drug	clozapine	GRIA1 GRIA2 PCK1 GABRA5	2.49e-04	274	26	4	CID000002818
Drug	CX546	GRIA1 GRIA2	2.60e-04	21	26	2	CID000002890
Drug	AC1L1B62	GRIA1 GRIA2	2.60e-04	21	26	2	CID000001299
Drug	imidazenil	GRIA1 GABRA5	2.86e-04	22	26	2	CID000119194
Drug	Fe-mo-s Cluster	GRIA1 GRIA2	2.86e-04	22	26	2	CID000445682
Drug	anisamide	GRIA1 GRIA2	2.86e-04	22	26	2	CID000075540
Drug	NS 102	GRIA1 GRIA2	2.86e-04	22	26	2	CID005282252
Drug	CX516	GRIA1 GRIA2	2.86e-04	22	26	2	CID000148184
Drug	YM90K	GRIA1 GRIA2	3.13e-04	23	26	2	CID005486547
Drug	CGP 39653	GRIA1 GRIA2	3.41e-04	24	26	2	CID006437837
Drug	pD 8	GRIA1 GRIA2	3.41e-04	24	26	2	CID000656948
Drug	kynurenic acid	GRIA1 GRIA2 GABRA5	3.57e-04	122	26	3	CID000003845
Drug	gavestinel	GRIA1 GRIA2	3.70e-04	25	26	2	CID006450546
Disease	central nervous system disease (implicated_via_orthology)	GRIA1 GRIA2	8.89e-05	16	26	2	DOID:331 (implicated_via_orthology)
Disease	Hyperkinesia, Generalized	GRIA1 GRIA2	3.64e-04	32	26	2	C0751217
Disease	Hyperkinesia	GRIA1 GRIA2	3.64e-04	32	26	2	C3887506
Disease	Withdrawal Symptoms	GRIA1 GRIA2	1.20e-03	58	26	2	C0087169
Disease	Drug Withdrawal Symptoms	GRIA1 GRIA2	1.20e-03	58	26	2	C0086189
Disease	Substance Withdrawal Syndrome	GRIA1 GRIA2	1.20e-03	58	26	2	C0038587
Disease	electroencephalogram measurement	SASH1 TMEM117	1.94e-03	74	26	2	EFO_0004357
Disease	S-6-hydroxywarfarin to S-warfarin ratio measurement	PRDM9 PCK1	2.73e-03	88	26	2	EFO_0803332
Disease	status epilepticus (biomarker_via_orthology)	GRIA1 GRIA2	3.50e-03	100	26	2	DOID:1824 (biomarker_via_orthology)
Disease	Seizures, Focal	GRIA2 GABRA5	3.78e-03	104	26	2	C0751495
Disease	Myoclonic Seizures	GRIA2 GABRA5	3.78e-03	104	26	2	C4317123
Disease	Tonic - clonic seizures	GRIA2 GABRA5	3.78e-03	104	26	2	C0494475
Disease	Left-Sided Heart Failure	OLR1 PCK1	4.22e-03	110	26	2	C0023212
Disease	Myocardial Failure	OLR1 PCK1	4.22e-03	110	26	2	C1959583
Disease	Heart Failure, Right-Sided	OLR1 PCK1	4.22e-03	110	26	2	C0235527
Disease	Congestive heart failure	OLR1 PCK1	4.22e-03	110	26	2	C0018802
Disease	Heart failure	OLR1 PCK1	4.22e-03	110	26	2	C0018801
Disease	Heart Decompensation	OLR1 PCK1	4.22e-03	110	26	2	C1961112
Disease	Cocaine-Related Disorders	GRIA1 GRIA2	4.76e-03	117	26	2	C0236736
Disease	Cocaine Abuse	GRIA1 GRIA2	5.58e-03	127	26	2	C0009171

Protein segments in the cluster

Peptide	Gene	Start	Entry
GFGWWFFLGPKFKKL	SLC33A1	521	O00400
FKKFFTQGWAGWRKK	AKAP12	296	Q02952
WFRKDKEGKFLWPGF	PCK1	516	P35558
KGWLTKQYEDGQWKK	MPRIP	391	Q6WCQ1
YKRGALLKGWKPRWF	SBF2	1751	Q86WG5
WKGEKSKYPQGRFWK	IL1RAP	526	Q9NPH3
DKLKNKWWYDKGECG	GRIA2	781	P42262
IFLGWEKGAYKKWGK	KIAA0232	81	Q92628
VNYFTKRGWAWDGKK	GABRA5	341	P31644
GKKAKGLQFLYSPWW	OLR1	21	P78380
KFSGFGKIFKPWKWR	PHACTR4	36	Q8IZ21
YGQELGIKWGSKWKK	PRDM9	361	Q9NQV7
NWIKQWKLGLKFDGK	OTULIN	166	Q96BN8
VRKGKVEYLVKWKGW	CBX7	21	O95931
EKQGEWHKKWKEFLG	HAUS6	371	Q7Z4H7
GLLDKLKNKWWYDKG	GRIA1	771	P42261
KKKGAIYEGDWKFGK	MORN3	56	Q6PF18
KCRRVYSGWWKGDKK	MORN3	86	Q6PF18
YSGWWKGDKKSGYGI	MORN3	91	Q6PF18
KYKKKMWGWLWTEAG	PDIA6	326	Q15084
GLKKKNNTEKGWDWY	TAF1B	61	Q53T94
YAKRKGWWDGKKEFD	SCRN3	206	Q0VDG4
GKYKTWKKWLDDEGQ	CHST3	316	Q7LGC8
SVGKGDWKKKNKYFW	SASH1	141	O94885
GGWFSGLWGKKESKK	VPS13C	471	Q709C8
YPDWGKSARAFWKKG	TMEM117	181	Q9H0C3
LKKLAKQGWYWGPIT	SOCS6	376	O14544
IKWFKGKWLELGSKS	MYBPC2	86	Q14324