Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	NADH oxidase H202-forming activity	DUOX2 DUOX1	5.61e-05	2	150	2	GO:0106293
GeneOntologyMolecularFunction	hydrolase activity, acting on glycosyl bonds	MAN2C1 MAN2B1 GBE1 NEU3 CEMIP OVGP1 UNG	1.09e-04	144	150	7	GO:0016798
GeneOntologyMolecularFunction	carbohydrate binding	SIGLEC12 MAN2C1 MAN2B1 GBE1 REG1A CEMIP LMAN1L MRC2 PPP1R3F GALNT4	1.21e-04	310	150	10	GO:0030246
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	MAN2C1 MAN2B1 GBE1 NEU3 CEMIP OVGP1	1.28e-04	103	150	6	GO:0004553
GeneOntologyMolecularFunction	mannose-ethanolamine phosphotransferase activity	PIGN PIGO	3.33e-04	4	150	2	GO:0051377
GeneOntologyMolecularFunction	L-lactate dehydrogenase activity	LDHA LDHC	5.52e-04	5	150	2	GO:0004459
GeneOntologyMolecularFunction	NADPH oxidase H202-forming activity	DUOX2 DUOX1	5.52e-04	5	150	2	GO:0106294
Domain	NPIP	NPIPB3 NPIPB5 NPIPB13 NPIPA2	3.76e-06	14	150	4	IPR009443
Domain	DUOX1	DUOX2 DUOX1	6.41e-05	2	150	2	IPR029595
Domain	WASPfam_EVH1	WASL WAS	6.41e-05	2	150	2	IPR033927
Domain	-	DCT TYRP1	1.91e-04	3	150	2	1.10.1280.10
Domain	Unchr_di-copper_centre	DCT TYRP1	1.91e-04	3	150	2	IPR008922
Domain	TYROSINASE_1	DCT TYRP1	1.91e-04	3	150	2	PS00497
Domain	TYROSINASE_2	DCT TYRP1	1.91e-04	3	150	2	PS00498
Domain	-	RASA4 RASA4B	1.91e-04	3	150	2	4.10.1130.10
Domain	Tyrosinase	DCT TYRP1	1.91e-04	3	150	2	PF00264
Domain	Tyrosinase_Cu-bd	DCT TYRP1	1.91e-04	3	150	2	IPR002227
Domain	PTPc	PTPRT PTPN12 PTPRA PTPRJ	1.93e-04	36	150	4	SM00194
Domain	TYR_PHOSPHATASE_PTP	PTPRT PTPN12 PTPRA PTPRJ	2.64e-04	39	150	4	PS50055
Domain	PTPase_domain	PTPRT PTPN12 PTPRA PTPRJ	3.21e-04	41	150	4	IPR000242
Domain	Y_phosphatase	PTPRT PTPN12 PTPRA PTPRJ	3.21e-04	41	150	4	PF00102
Domain	Coact_PPARg	FAM120A FAM120C	3.80e-04	4	150	2	IPR026784
Domain	Fd_Rdtase_FAD-bd	DUOX2 DUOX1 NOS1	4.48e-04	19	150	3	IPR017927
Domain	FAD_FR	DUOX2 DUOX1 NOS1	4.48e-04	19	150	3	PS51384
Domain	Riboflavin_synthase-like_b-brl	DUOX2 DUOX1 NOS1	4.48e-04	19	150	3	IPR017938
Domain	Glyco_hydro_38_C	MAN2C1 MAN2B1	6.31e-04	5	150	2	IPR011682
Domain	Alpha-mann_mid	MAN2C1 MAN2B1	6.31e-04	5	150	2	PF09261
Domain	Glyco_hydro_57/38_cen	MAN2C1 MAN2B1	6.31e-04	5	150	2	IPR028995
Domain	L_LDH	LDHA LDHC	6.31e-04	5	150	2	PS00064
Domain	Glyco_hydro_38	MAN2C1 MAN2B1	6.31e-04	5	150	2	PF01074
Domain	-	MAN2C1 MAN2B1	6.31e-04	5	150	2	1.20.1270.50
Domain	-	MAN2C1 MAN2B1	6.31e-04	5	150	2	3.20.110.10
Domain	Alpha-mann_mid	MAN2C1 MAN2B1	6.31e-04	5	150	2	SM00872
Domain	L-lactate_DH	LDHA LDHC	6.31e-04	5	150	2	IPR011304
Domain	L-lactate_DH_AS	LDHA LDHC	6.31e-04	5	150	2	IPR018177
Domain	Glyco_hydro_38_N	MAN2C1 MAN2B1	6.31e-04	5	150	2	IPR000602
Domain	Glyco_hydro_38/57_N	MAN2C1 MAN2B1	6.31e-04	5	150	2	IPR027291
Domain	DMAP_binding	DIP2B DIP2A	6.31e-04	5	150	2	PF06464
Domain	Glyco_hydro_38_cen	MAN2C1 MAN2B1	6.31e-04	5	150	2	IPR015341
Domain	Glyco_hydro_38C	MAN2C1 MAN2B1	6.31e-04	5	150	2	PF07748
Domain	DMAP1-bd	DIP2B DIP2A	9.41e-04	6	150	2	IPR010506
Domain	Peptidase_S8_Asp-AS	FURIN PCSK4	9.41e-04	6	150	2	IPR023827
Domain	WxxW_domain	CEMIP MUC5AC	9.41e-04	6	150	2	IPR025155
Domain	Mucin2_WxxW	CEMIP MUC5AC	9.41e-04	6	150	2	PF13330
Domain	DMAP_binding	DIP2B DIP2A	9.41e-04	6	150	2	SM01137
Domain	WD40	GRWD1 COPA WDR33 ARPC1A APAF1 WDR59 DCAF5 IFT80	1.19e-03	259	150	8	PF00400
Domain	PTPc_motif	PTPRT PTPN12 PTPRA PTPRJ	1.29e-03	59	150	4	SM00404
Domain	Tyr_Pase_cat	PTPRT PTPN12 PTPRA PTPRJ	1.29e-03	59	150	4	IPR003595
Domain	WASP_C	WASL WAS	1.31e-03	7	150	2	IPR011026
Domain	P_proprotein	FURIN PCSK4	1.31e-03	7	150	2	PF01483
Domain	S8_pro-domain	FURIN PCSK4	1.31e-03	7	150	2	IPR032815
Domain	PrprotnconvertsP	FURIN PCSK4	1.31e-03	7	150	2	IPR002884
Domain	Glyco_hydro/deAcase_b/a-brl	MAN2C1 MAN2B1	1.31e-03	7	150	2	IPR011330
Domain	NAD_binding_6	DUOX2 DUOX1	1.31e-03	7	150	2	PF08030
Domain	FAD_binding_8	DUOX2 DUOX1	1.31e-03	7	150	2	PF08022
Domain	-	FURIN PCSK4	1.31e-03	7	150	2	3.30.70.850
Domain	S8_pro-domain	FURIN PCSK4	1.31e-03	7	150	2	PF16470
Domain	FAD-bd_8	DUOX2 DUOX1	1.31e-03	7	150	2	IPR013112
Domain	Fe_red_NAD-bd_6	DUOX2 DUOX1	1.31e-03	7	150	2	IPR013121
Domain	WD40	GRWD1 COPA WDR33 ARPC1A APAF1 WDR59 DCAF5 IFT80	1.48e-03	268	150	8	SM00320
Domain	WD40_repeat	GRWD1 COPA WDR33 ARPC1A APAF1 WDR59 DCAF5 IFT80	1.62e-03	272	150	8	IPR001680
Domain	Lactate/malate_DH_N	LDHA LDHC	1.74e-03	8	150	2	IPR001236
Domain	L-lactate/malate_DH	LDHA LDHC	1.74e-03	8	150	2	IPR001557
Domain	Ldh_1_N	LDHA LDHC	1.74e-03	8	150	2	PF00056
Domain	WD_REPEATS_1	GRWD1 COPA WDR33 ARPC1A APAF1 WDR59 DCAF5 IFT80	1.86e-03	278	150	8	PS00678
Domain	WD_REPEATS_2	GRWD1 COPA WDR33 ARPC1A APAF1 WDR59 DCAF5 IFT80	1.90e-03	279	150	8	PS50082
Domain	WD_REPEATS_REGION	GRWD1 COPA WDR33 ARPC1A APAF1 WDR59 DCAF5 IFT80	1.90e-03	279	150	8	PS50294
Domain	fn3	IGFN1 OBSCN PTPRT PTPRJ TRIM9 IGSF9	1.99e-03	162	150	6	PF00041
Domain	Peptidase_S8_His-AS	FURIN PCSK4	2.22e-03	9	150	2	IPR022398
Domain	BTK	RASA4 RASA4B	2.22e-03	9	150	2	SM00107
Domain	-	LDHA LDHC	2.22e-03	9	150	2	3.90.110.10
Domain	Lactate/malate_DH_C	LDHA LDHC	2.22e-03	9	150	2	IPR022383
Domain	Ldh_1_C	LDHA LDHC	2.22e-03	9	150	2	PF02866
Domain	Peptidase_S8_Ser-AS	FURIN PCSK4	2.22e-03	9	150	2	IPR023828
Domain	Lactate_DH/Glyco_Ohase_4_C	LDHA LDHC	2.22e-03	9	150	2	IPR015955
Domain	Znf_Btk_motif	RASA4 RASA4B	2.22e-03	9	150	2	IPR001562
Domain	BTK	RASA4 RASA4B	2.22e-03	9	150	2	PF00779
Domain	ZF_BTK	RASA4 RASA4B	2.22e-03	9	150	2	PS51113
Domain	PH_dom-like	WASL WAS ASAP3 OBSCN APBA2 ANKS1B JAK3 RASA4 RASA4B ARAP1	2.36e-03	426	150	10	IPR011993
Domain	An_peroxidase	DUOX2 DUOX1	2.76e-03	10	150	2	PF03098
Domain	Haem_peroxidase_animal	DUOX2 DUOX1	2.76e-03	10	150	2	IPR019791
Domain	Phosphodiest/P_Trfase	PIGN PIGO	2.76e-03	10	150	2	IPR002591
Domain	Peptidase_S8_subtilisin-rel	FURIN PCSK4	2.76e-03	10	150	2	IPR015500
Domain	Haem_peroxidase	DUOX2 DUOX1	2.76e-03	10	150	2	IPR010255
Domain	Phosphodiest	PIGN PIGO	2.76e-03	10	150	2	PF01663
Domain	PEROXIDASE_3	DUOX2 DUOX1	2.76e-03	10	150	2	PS50292
Domain	SUBTILASE_ASP	FURIN PCSK4	2.76e-03	10	150	2	PS00136
Domain	SUBTILASE_HIS	FURIN PCSK4	2.76e-03	10	150	2	PS00137
Domain	SUBTILASE_SER	FURIN PCSK4	2.76e-03	10	150	2	PS00138
Domain	-	DUOX2 DUOX1	2.76e-03	10	150	2	1.10.640.10
Domain	WD40_repeat_dom	GRWD1 COPA WDR33 ARPC1A APAF1 WDR59 DCAF5 IFT80	2.79e-03	297	150	8	IPR017986
Domain	Tyr_Pase_AS	PTPRT PTPN12 PTPRA PTPRJ	2.83e-03	73	150	4	IPR016130
Domain	-	FURIN PCSK4	3.36e-03	11	150	2	3.40.50.200
Domain	WH1	WASL WAS	3.36e-03	11	150	2	SM00461
Domain	Peptidase_S8/S53_dom	FURIN PCSK4	3.36e-03	11	150	2	IPR000209
Domain	WH1/EVH1_dom	WASL WAS	3.36e-03	11	150	2	IPR000697
Domain	WH1	WASL WAS	3.36e-03	11	150	2	PF00568
Domain	Peptidase_S8	FURIN PCSK4	3.36e-03	11	150	2	PF00082
Domain	FN3	IGFN1 OBSCN PTPRT PTPRJ TRIM9 IGSF9	3.84e-03	185	150	6	SM00060
Domain	-	WASL WAS	4.01e-03	12	150	2	3.90.810.10
Domain	Ferric_reduct	DUOX2 DUOX1	4.01e-03	12	150	2	PF01794
Domain	Fe3_Rdtase_TM_dom	DUOX2 DUOX1	4.01e-03	12	150	2	IPR013130
Domain	-	WASL WAS ASAP3 OBSCN APBA2 ANKS1B RASA4 RASA4B ARAP1	4.39e-03	391	150	9	2.30.29.30
Domain	Ig-like_fold	SIGLEC12 IGFN1 HLA-DMA OBSCN GBE1 PTPRT LY6G6F PTPRJ TRIM9 VSTM2L IGSF9 FGFR3 ADGRF3	4.59e-03	706	150	13	IPR013783
Domain	WH1	WASL WAS	4.72e-03	13	150	2	PS50229
Domain	TYR_PHOSPHATASE_1	PTPRT PTPN12 PTPRA PTPRJ	5.10e-03	86	150	4	PS00383
Domain	TYR_PHOSPHATASE_dom	PTPRT PTPN12 PTPRA PTPRJ	5.31e-03	87	150	4	IPR000387
Pubmed	Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element.	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	9.07e-17	12	162	8	10433963
Pubmed	Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy.	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	2.35e-16	13	162	8	17668377
Pubmed	The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	3.33e-16	8	162	7	17588759
Pubmed	DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	4.95e-15	10	162	7	17984056
Pubmed	Characterization of a tandemly repeated 3.3-kb KpnI unit in the facioscapulohumeral muscular dystrophy (FSHD) gene region on chromosome 4q35.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	7.00e-14	13	162	7	7739628
Pubmed	Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	7.81e-13	17	162	7	11245978
Pubmed	Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.	WASL WAS COPA WRNIP1 GBE1 SH2D2A LDHA PRDX6 JAK3 PTPRA FAM120A SQSTM1	4.98e-08	327	162	12	15592455
Pubmed	Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development.	DUX4L9 DUX4L2 DUX4L4	3.95e-07	4	162	3	17911620
Pubmed	The homeobox transcription factor DUXBL controls exit from totipotency.	DUX4L9 DUX4L2 DUX4L4	3.95e-07	4	162	3	38509386
Pubmed	Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex.	WDR33 CPSF1 FIP1L1	3.95e-07	4	162	3	29274231
Pubmed	Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl.	DUX4L9 DUX4L2 DUX4L4	9.85e-07	5	162	3	20063414
Pubmed	Association of the OCA2 polymorphism His615Arg with melanin content in east Asian populations: further evidence of convergent evolution of skin pigmentation.	DCT TYRP1 ADAM17	9.85e-07	5	162	3	20221248
Pubmed	The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.	DUX4L9 DUX4L2 DUX4L4	3.42e-06	7	162	3	30765463
Pubmed	Clustering of six human 11p15 gene homologs within a 500-kb interval of proximal mouse chromosome 7.	LDHA LDHC KCNC1	3.42e-06	7	162	3	7698755
Pubmed	Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification.	PTPN12 PTPRA PTPRJ	3.42e-06	7	162	3	1932742
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	PIGN FAT4 EOGT ATP6AP1 MAN2B1 COPA TM9SF1 PTPN12 MEGF8 PTPRJ MRC2 SQSTM1 FURIN CPSF1 ADAM17 ATP2A3 PIGO DNASE2 GALNT4	3.60e-06	1201	162	19	35696571
Pubmed	Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human.	LDHC FURIN PCSK4	5.46e-06	8	162	3	7782070
Pubmed	Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase.	GRIN2C GRIN3B NOS1	1.59e-05	11	162	3	8581564
Pubmed	Digenic DUOX1 and DUOX2 Mutations in Cases With Congenital Hypothyroidism.	DUOX2 DUOX1	2.16e-05	2	162	2	28633507
Pubmed	Functional properties of cloned melanogenic proteins.	DCT TYRP1	2.16e-05	2	162	2	1292007
Pubmed	Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice.	WASL WAS	2.16e-05	2	162	2	20071778
Pubmed	N-WASP has the ability to compensate for the loss of WASP in macrophage podosome formation and chemotaxis.	WASL WAS	2.16e-05	2	162	2	20599953
Pubmed	Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia.	SAT1 SMOX	2.16e-05	2	162	2	33054763
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4 RASA4B	2.16e-05	2	162	2	11448776
Pubmed	Reactive oxygen species regulate the levels of dual oxidase (Duox1-2) in human neuroblastoma cells.	DUOX2 DUOX1	2.16e-05	2	162	2	22523549
Pubmed	Expression of dual oxidases and secreted cytokines in chronic rhinosinusitis.	DUOX2 DUOX1	2.16e-05	2	162	2	23281318
Pubmed	Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A.	LDHA LDHC	2.16e-05	2	162	2	30590713
Pubmed	Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain.	TGFB1I1 PTPN12	2.16e-05	2	162	2	10092676
Pubmed	Dual oxidase 1 and NADPH oxidase 2 exert favorable effects in cervical cancer patients by activating immune response.	DUOX2 DUOX1	2.16e-05	2	162	2	31706280
Pubmed	The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines.	SAT1 SMOX	2.16e-05	2	162	2	19727732
Pubmed	Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury.	SAT1 SMOX	2.16e-05	2	162	2	28886181
Pubmed	N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.	WASL WAS	2.16e-05	2	162	2	11584271
Pubmed	Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity.	DUOX2 DUOX1	2.16e-05	2	162	2	15972824
Pubmed	Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers.	SAT1 SMOX	2.16e-05	2	162	2	24025154
Pubmed	N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters.	WASL WAS	2.16e-05	2	162	2	38085658
Pubmed	Identification of mutations in the pigment cell-specific gene located at the brown locus in mouse.	DCT TYRP1	2.16e-05	2	162	2	1409444
Pubmed	Conserved cysteine residues provide a protein-protein interaction surface in dual oxidase (DUOX) proteins.	DUOX2 DUOX1	2.16e-05	2	162	2	23362256
Pubmed	Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation.	DUOX2 DUOX1	2.16e-05	2	162	2	19144650
Pubmed	Defective regulation of microRNA target genes in myoblasts from facioscapulohumeral dystrophy patients.	DUX4L9 DUX4	2.16e-05	2	162	2	24145033
Pubmed	Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin.	SAT1 SMOX	2.16e-05	2	162	2	12141946
Pubmed	Expression of nicotinamide adenine dinucleotide phosphate oxidase flavoprotein DUOX genes and proteins in human papillary and follicular thyroid carcinomas.	DUOX2 DUOX1	2.16e-05	2	162	2	11762710
Pubmed	Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.	DUOX2 DUOX1	2.16e-05	2	162	2	11822874
Pubmed	Tyrosinase-related protein-2 and -1 are trafficked on distinct routes in B16 melanoma cells.	DCT TYRP1	2.16e-05	2	162	2	15707965
Pubmed	Starvation induced autophagy promotes the progression of bladder cancer by LDHA mediated metabolic reprogramming.	AXIN1 SQSTM1	2.16e-05	2	162	2	34743698
Pubmed	Dual oxidase 1 and 2 expression in airway epithelium of smokers and patients with mild/moderate chronic obstructive pulmonary disease.	DUOX2 DUOX1	2.16e-05	2	162	2	18177232
Pubmed	Sirtuin4 suppresses the anti-neuroinflammatory activity of infiltrating regulatory T cells in the traumatically injured spinal cord.	SIRT4 FOXP3	2.16e-05	2	162	2	31559637
Pubmed	Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U).	WASL WAS	2.16e-05	2	162	2	18650809
Pubmed	Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense.	DUOX2 DUOX1	2.16e-05	2	162	2	12824283
Pubmed	Differential expression of a novel murine non-receptor protein tyrosine phosphatase during differentiation of P19 embryonal carcinoma cells.	PTPN12 PTPRA	2.16e-05	2	162	2	1590786
Pubmed	Congenital Hypothyroidism due to Oligogenic Mutations in Two Sudanese Families.	DUOX2 DUOX1	2.16e-05	2	162	2	30375286
Pubmed	Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells.	ADAM17 MUC5AC	2.16e-05	2	162	2	12972643
Pubmed	Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.	DUOX2 DUOX1	2.16e-05	2	162	2	10806195
Pubmed	Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.	DUOX2 DUOX1	2.16e-05	2	162	2	11514595
Pubmed	Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family.	DCT TYRP1	2.16e-05	2	162	2	8530077
Pubmed	A cDNA encoding tyrosinase-related protein maps to the brown locus in mouse.	DCT TYRP1	2.16e-05	2	162	2	3132713
Pubmed	Roles of DUOX-mediated hydrogen peroxide in metabolism, host defense, and signaling.	DUOX2 DUOX1	2.16e-05	2	162	2	24161126
Pubmed	Wiskott-Aldrich syndrome: a comprehensive review.	WASL WAS	2.16e-05	2	162	2	23527602
Pubmed	Neuronal Wiskott-Aldrich syndrome protein regulates Pseudomonas aeruginosa-induced lung vascular permeability through the modulation of actin cytoskeletal dynamics.	WASL WAS	2.16e-05	2	162	2	31916311
Pubmed	Expression of reduced nicotinamide adenine dinucleotide phosphate oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid tissues.	DUOX2 DUOX1	2.16e-05	2	162	2	11443211
Pubmed	Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas.	DUOX2 DUOX1	2.16e-05	2	162	2	10601291
Pubmed	GRWD1 Over-Expression Promotes Gastric Cancer Progression by Activating Notch Signaling Pathway via Up-Regulation of ADAM17.	GRWD1 ADAM17	2.16e-05	2	162	2	38172445
Pubmed	Human lactate dehydrogenase A (LDHA) rescues mouse Ldhc-null sperm function.	LDHA LDHC	2.16e-05	2	162	2	23467744
Pubmed	Complex signatures of selection for the melanogenic loci TYR, TYRP1 and DCT in humans.	DCT TYRP1	2.16e-05	2	162	2	18312627
Pubmed	Abundance of repetitive sequence elements in the mouse testis-specific lactate dehydrogenase-C gene.	LDHA LDHC	2.16e-05	2	162	2	14581519
Pubmed	Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate.	ATP6AP1 FURIN	2.16e-05	2	162	2	18713856
Pubmed	The extracellular A-loop of dual oxidases affects the specificity of reactive oxygen species release.	DUOX2 DUOX1	2.16e-05	2	162	2	25586178
Pubmed	Localization of Kex2-like processing endoproteases, furin and PC4, within mouse testis by in situ hybridization.	FURIN PCSK4	2.16e-05	2	162	2	8422932
Pubmed	Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium.	DUOX2 DUOX1	2.16e-05	2	162	2	16111680
Pubmed	X-ray scattering study of activated Arp2/3 complex with bound actin-WCA.	WASL WAS	2.16e-05	2	162	2	18462674
Pubmed	Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells.	DUOX1 MUC5AC	2.16e-05	2	162	2	15640347
Pubmed	Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases.	DUOX2 DUOX1	2.16e-05	2	162	2	11753072
Pubmed	Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer.	DUOX2 DUOX1	2.16e-05	2	162	2	18281478
Pubmed	Structural and functional characterization of the two human ThOX/Duox genes and their 5'-flanking regions.	DUOX2 DUOX1	2.16e-05	2	162	2	15062544
Pubmed	Regulation of DHICA-mediated antioxidation by dopachrome tautomerase: implication for skin photoprotection against UVA radiation.	DCT TYRP1	2.16e-05	2	162	2	20123016
Pubmed	Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.	WASL WAS	2.16e-05	2	162	2	17878299
Pubmed	Regulated hydrogen peroxide production by Duox in human airway epithelial cells.	DUOX2 DUOX1	2.16e-05	2	162	2	15677770
Pubmed	An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.	RASA4 RASA4B	2.16e-05	2	162	2	16041389
Pubmed	Mucosal reactive oxygen species are required for antiviral response: role of Duox in influenza a virus infection.	DUOX2 DUOX1	2.16e-05	2	162	2	24128054
Pubmed	Customised molecular diagnosis of primary immune deficiency disorders in New Zealand: an efficient strategy for a small developed country.	WAS JAK3 UNG	2.74e-05	13	162	3	19859091
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	ATP6AP1 ILK MAN2B1 COPA LDHA NUP205 MEGF8 PTPRJ MRC2 AFG3L2 ADAM17 DNASE2	3.30e-05	613	162	12	22268729
Pubmed	Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation.	WDR33 NUP205 FAM120A SQSTM1 CPSF1 FIP1L1	3.30e-05	129	162	6	28973437
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	WRNIP1 LDHA NUP205 INTS5 FAM120A SQSTM1 RASA4B ZMYM5	3.39e-05	262	162	8	36880596
Pubmed	Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice.	DUX4L9 DUX4L2 DUX4L4	4.33e-05	15	162	3	35727972
Pubmed	The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling.	HEY1 FURIN ADAM17	4.33e-05	15	162	3	21205794
Pubmed	Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins.	DUX4L9 DUX4L2 DUX4L4	4.33e-05	15	162	3	30071041
Pubmed	Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.	MAN2C1 MAN2B1 NEU3	4.33e-05	15	162	3	8892864
Pubmed	Molecular analysis of 36 mutations at the mouse pink-eyed dilution (p) locus.	LDHA LDHC KCNC1	5.31e-05	16	162	3	8601494
Pubmed	Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis.	PIGN PIGV PIGO	6.43e-05	17	162	3	11102867
Pubmed	Protein tyrosine phosphatases expression during development of mouse superior colliculus.	PTPN12 PTPRA PTPRJ	6.43e-05	17	162	3	19727691
Pubmed	Localization of the tight junction protein gene TJP1 to human chromosome 15q13, distal to the Prader-Willi/Angelman region, and to mouse chromosome 7.	LDHC FURIN	6.45e-05	3	162	2	8825647
Pubmed	Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism.	LDHA FOXP3	6.45e-05	3	162	2	27708054
Pubmed	Nitric oxide is an activity-dependent regulator of target neuron intrinsic excitability.	KCNC1 NOS1	6.45e-05	3	162	2	21791288
Pubmed	CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.	RASA4 RASA4B	6.45e-05	3	162	2	25637021
Pubmed	Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients.	DCT TYRP1	6.45e-05	3	162	2	17200659
Pubmed	Identifying the association between single nucleotide polymorphisms in KCNQ1, ARAP1, and KCNJ11 and type 2 diabetes mellitus in a Chinese population.	KCNJ11 ARAP1	6.45e-05	3	162	2	32922204
Pubmed	Human neutrophil elastase induces MUC5AC overexpression in chronic rhinosinusitis through tumour necrosis factor-α converting enzyme.	ADAM17 MUC5AC	6.45e-05	3	162	2	26881964
Pubmed	Anemonin is a natural bioactive compound that can regulate tyrosinase-related proteins and mRNA in human melanocytes.	DCT TYRP1	6.45e-05	3	162	2	17766092
Pubmed	Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway.	WASL WAS	6.45e-05	3	162	2	11340081
Pubmed	Beta-agonists enhance the lactic dehydrogenase (LDH) expression in serum and ventricular myocytes of mice.	LDHA LDHC	6.45e-05	3	162	2	17853776
Pubmed	Excreted-secreted antigens of Toxoplasma gondii inhibit Foxp3 via IL-2Rγ/JAK3/Stats pathway.	JAK3 FOXP3	6.45e-05	3	162	2	30129110
Cytoband	4q35.2	DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	4.90e-10	27	162	6	4q35.2
Cytoband	Ensembl 112 genes in cytogenetic band chr4q35	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	9.94e-09	117	162	8	chr4q35
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	ILK TSSC4 LDHA LDHC OR51B5 KCNC1 KCNJ11 MUC5AC OR51B2	1.92e-04	564	162	9	chr11p15
Cytoband	16p12.2	NPIPB4 NPIPB3 NPIPB5	3.07e-04	37	162	3	16p12.2
GeneFamily	PRD class homeoboxes and pseudogenes	DUX4L9 DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	1.46e-06	92	110	7	521
GeneFamily	WD repeat domain containing	GRWD1 COPA WDR33 ARPC1A APAF1 WDR59 DCAF5 IFT80	2.00e-04	262	110	8	362
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRT PTPRA PTPRJ	2.69e-04	21	110	3	813
GeneFamily	Glycosyl transferases group 1 domain containing\|Phosphatidylinositol glycan anchor biosynthesis	PIGN PIGV PIGO	2.69e-04	21	110	3	680
GeneFamily	Mannosidases alpha class 2	MAN2C1 MAN2B1	3.62e-04	5	110	2	1194
GeneFamily	Fibronectin type III domain containing	IGFN1 OBSCN PTPRT PTPRJ TRIM9 IGSF9	4.39e-04	160	110	6	555
GeneFamily	Glutamate ionotropic receptor NMDA type subunits	GRIN2C GRIN3B	7.55e-04	7	110	2	1201
GeneFamily	Proprotein convertase subtilisin/kexin family	FURIN PCSK4	1.28e-03	9	110	2	973
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4 RASA4B	1.60e-03	10	110	2	830
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	SIGLEC12 IGFN1 OBSCN IGSF9 FGFR3	3.04e-03	161	110	5	593
GeneFamily	Wiskott-Aldrich Syndrome protein family	WASL WAS	4.16e-03	16	110	2	14
ToppCell	COPD\|World / Disease state, Lineage and Cell class	NPIPB4 AOAH APBA2 NPIPB3 SH2D2A AOC3 NKG7	4.74e-06	189	156	7	53577632683686dc493a5a3fdc01887ec5c320f2
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-MAIT\|lymph-node_spleen / Manually curated celltypes from each tissue	SH2D2A IL17RE SQSTM1 FURIN SCART1 NKG7 GFPT2	4.74e-06	189	156	7	afe3a4fe7c10eeeb7064129778d940269c9acbef
ToppCell	IPF-Lymphoid-NK\|Lymphoid / Disease state, Lineage and Cell class	AOAH APBA2 AXIN1 DIP2A PTPN12 PTPRJ NKG7	5.08e-06	191	156	7	f2ddc0962007d7a4e78fbd916ebb62fc557d480a
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT4 IGFN1 ITGBL1 MRC2 AOC3 CYP7B1 GFPT2	6.22e-06	197	156	7	94a9603cbd3516fbcce871909693b88f20d41713
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-Macrophages\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SIGLEC12 MAN2B1 WAS HLA-DMA ACP5 AOAH SAT1	6.65e-06	199	156	7	9df2c79904dacf029ec9df1f1cde72d871189a82
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ILK GBE1 TGFB1I1 LMAN1L SQSTM1 GFPT2 SMOX	6.65e-06	199	156	7	85bb28369e0568b7b3bda095722102fc793f60ef
ToppCell	COVID-19_Mild-PLT_1\|COVID-19_Mild / Disease Group and Platelet Clusters	ILK CARD19 PRDX6 LY6G6F SAT1 SQSTM1 SMOX	6.65e-06	199	156	7	7f32958a73bc6020ea8a0e595ec749bbfe74c1b3
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-Macroglial-Glia_progenitor_cell\|2m / Sample Type, Dataset, Time_group, and Cell type.	ANKS1B LDHA LCNL1 SAT1 TRIM9 SQSTM1 DNASE2	6.87e-06	200	156	7	fc9e2094f4d22412e3dd79e79649a6d46d62caec
ToppCell	facs-Heart-RV-24m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 NAALADL1 NKG7 CMTR2 PCSK4 PIGO	8.20e-06	135	156	6	99e7ac9b1139fe4ff036f6f048a8f1cc514c1fb9
ToppCell	facs-Heart-RV-24m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 NAALADL1 NKG7 CMTR2 PCSK4 PIGO	8.20e-06	135	156	6	1fe684ed5913ae757ad6befbbe12d1bee481dd12
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNE5 RENBP METTL24 PPP1R3F GALNT4 ARAP1	9.30e-06	138	156	6	6b83c434895d82eaf3c222eef27acec76f9c0a77
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-4\|TCGA-Kidney / Sample_Type by Project: Shred V9	DGKZ SH2D2A LDHA JAK3 NKG7 FOXP3	2.15e-05	160	156	6	45cb62a5186f3dd2a2fb86a8ebc952efb78e5e77
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_mature_unknown_2\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ANKRD66 PRDX6 SMG8 PIK3C2G PPP1R3F GFPT2	2.39e-05	163	156	6	e393e5ff885a42b2b44e430d3d5a58f5e50eb732
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ILK CHRDL2 TGFB1I1 TYRP1 FREM2 AOC3	2.39e-05	163	156	6	e526104a3a574ee860078ce7c049e7fec9443f37
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	WAS ANKS1B LDHA JAK3 KCNC1 PCSK4	2.93e-05	169	156	6	20fbf78382fb0ba9a63ab1aa0abc615476994ac5
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	KCTD11 DCAF5 FAM120C ZNF197 SLC41A1 ATP2A3	2.93e-05	169	156	6	c6e5b179461996ced6c7621dc01cec00d401f4e8
ToppCell	356C-Endothelial_cells-Endothelial-B_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ZNF438 WRNIP1 SIRT4 TRIM7 MRC2 NOS1	3.13e-05	171	156	6	6a2f88c2a62cb2f69797804e24eb1137a3e148de
ToppCell	356C-Endothelial_cells-Endothelial-B_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ZNF438 WRNIP1 SIRT4 TRIM7 MRC2 NOS1	3.13e-05	171	156	6	9be3554626408bb897d1f1c43b3ab4a92651f2e2
ToppCell	COVID-19-Heart-Fib_+_CM\|Heart / Disease (COVID-19 only), tissue and cell type	IGFN1 WFDC8 ITGBL1 CMTR2 NOS1	3.28e-05	104	156	5	0b60a56a46f1fe3f8224ec6399d009a34a117a21
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR27 WFDC8 CEMIP ADRA1B PIK3C2G PPP1R3F	3.34e-05	173	156	6	3059325901b1e5e12a1a91183f14267288b2f600
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	EOGT MAN2B1 WRNIP1 PTPRJ PPP1R3F FOXP3	3.34e-05	173	156	6	efb8072475000888efe088d00e870c56ffad4172
ToppCell	droplet-Liver-Npc-18m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIGN HLA-DMA SAT1 PTPRJ FAM120C ADAM17	3.34e-05	173	156	6	9ba55e21d1037ec3150d77895e52f0b051df65da
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR27 WFDC8 CEMIP ADRA1B PIK3C2G PPP1R3F	3.34e-05	173	156	6	36c8338463ee4cc432f568728d55989360f9a68d
ToppCell	Children_(3_yrs)-Immune-natural_killer_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	AOAH APBA2 LMAN1L DIP2A NKG7 ATP2A3	3.45e-05	174	156	6	33d6b81f31bfcb9c4b30206d88e20b9a94fba4a2
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	EOGT MAN2B1 WRNIP1 PTPRJ PPP1R3F FOXP3	3.45e-05	174	156	6	58300d64d3b6fd9ba1b6c87ea83b2777eb6be2f4
ToppCell	LPS-antiTNF\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP6AP1 CARD19 RENBP JAK3 SAT1 PTPRJ	3.92e-05	178	156	6	289d1425c4e57fabcca994b27f9af1c0ce5d5bec
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SIGLEC12 ACP5 RENBP AOC3 ADAM17 DNASE2	3.92e-05	178	156	6	0b398656f26c4061b11ccf98908d0e2e1367585a
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ILK CHRDL2 TGFB1I1 TYRP1 FREM2 AOC3	4.43e-05	182	156	6	7b86703559438e2d5ef3dad963ee0d772513f313
ToppCell	facs-Trachea-nan-24m-Lymphocytic\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D2A PRDX6 KCNC1 IL17RE NKG7 SMOX	4.57e-05	183	156	6	568c7e3bde7c6ad2c28ec02c2b073f482c337698
ToppCell	facs-Trachea-nan-24m-Lymphocytic-T_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D2A PRDX6 KCNC1 IL17RE NKG7 SMOX	4.57e-05	183	156	6	2b3ecfc51cdc5333345692747f4fed4c746a769d
ToppCell	facs-Trachea-nan-24m-Lymphocytic-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D2A PRDX6 KCNC1 IL17RE NKG7 SMOX	4.57e-05	183	156	6	79d7aac3b2483ca32430af5ac9f0e578ae064894
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	WASL POU3F1 PIGV ZNF197 ADGRF3 FOXP3	4.57e-05	183	156	6	3cbe0175d05fd39bc430de1ef471ff2c5b56460e
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 IGFN1 ABCA4 OBSCN FREM2 PIK3C2G	4.71e-05	184	156	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	Parenchymal-10x3prime_v2-Immune_Lymphocytic-T-T_CD8-CD8_TRM\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NPIPB4 NPIPB11 APBA2 POU3F1 JAK3 NKG7	4.71e-05	184	156	6	17ffa0e890960c00a3b5fa33d48caba66c61dbb0
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 IGFN1 ABCA4 OBSCN FREM2 PIK3C2G	4.71e-05	184	156	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 IGFN1 ABCA4 OBSCN FREM2 PIK3C2G	4.71e-05	184	156	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Bladder-BLADDER-1m-Hematologic-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WAS SH2D2A RASA4 IGSF9 NKG7 ATP2A3	4.86e-05	185	156	6	969248b63d4ce335f223528de756bcddffadbd77
ToppCell	facs-Trachea-24m-Hematologic-lymphocytic-T_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SH2D2A PRDX6 KCNC1 IL17RE NKG7 SMOX	5.16e-05	187	156	6	e4a219483118288d414d9017b81927255a5ab8bb
ToppCell	facs-Trachea-24m-Hematologic-lymphocytic-T_cell-T_cell_of_trachea\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SH2D2A PRDX6 KCNC1 IL17RE NKG7 SMOX	5.16e-05	187	156	6	81286565fcd51252c444e490b5f6d401c83b4666
ToppCell	COPD-Lymphoid-NK\|COPD / Disease state, Lineage and Cell class	AOAH APBA2 SH2D2A AXIN1 DIP2A NKG7	5.31e-05	188	156	6	c9a227c8e71b69929d43e9afb8306a95c8163778
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-B\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MAN2B1 GBE1 LDHA ANGPTL6 SAT1 NKG7	5.31e-05	188	156	6	977ebc0f88cb3ea3c422c85d84b3546229af5d3f
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-MMP9+_Inflammatory_macrophage\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SIGLEC12 ATP6AP1 ACP5 AOAH SAT1 DNASE2	5.31e-05	188	156	6	f955f2eb92f399958d4d713e31af77d93fb4a6ec
ToppCell	COPD-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	AOAH APBA2 SH2D2A AXIN1 DNAH12 NKG7	5.31e-05	188	156	6	186fe1ea328c942910190a4240262c0d8642ea3b
ToppCell	COPD-Lymphoid-NK\|World / Disease state, Lineage and Cell class	AOAH APBA2 SH2D2A AXIN1 DIP2A NKG7	5.47e-05	189	156	6	c0ac160fa7e68b92414fb1600abcac8ad1a42232
ToppCell	IPF-Lymphoid-NK\|IPF / Disease state, Lineage and Cell class	AOAH APBA2 SH2D2A AXIN1 DIP2A NKG7	5.47e-05	189	156	6	d92e880162450f8d01e4b8784eb625275cb8e03e
ToppCell	Control-Lymphoid-NK\|World / Disease state, Lineage and Cell class	AOAH APBA2 SH2D2A AXIN1 DIP2A NKG7	5.47e-05	189	156	6	89ef0d0e66dc96cacaae6be7aacdaa884e8e66a8
ToppCell	Control-Lymphoid-NK\|Lymphoid / Disease state, Lineage and Cell class	AOAH APBA2 AXIN1 DIP2A PTPN12 NKG7	5.63e-05	190	156	6	1584c68b58c7f406d9b0e8451beea3e6f8980c56
ToppCell	Control-Lymphoid-NK\|Control / Disease state, Lineage and Cell class	AOAH APBA2 SH2D2A AXIN1 DIP2A NKG7	5.63e-05	190	156	6	f7bd8521a40ac30a64dc439f17e2f6c7d021ef65
ToppCell	356C-Epithelial_cells-Epithelial-F_(Ciliated)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	ANKRD66 TMPRSS4 KLHDC9 DNAH12 VSTM2L GRIN3B	5.80e-05	191	156	6	8a5a2188b13ef4bbfd626a42565566708a751c1b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	AOAH APBA2 SH2D2A JAK3 NKG7 ATP2A3	5.80e-05	191	156	6	96a7179a845d3daa046ed71fa45c51255f130a7f
ToppCell	356C-Epithelial_cells-Epithelial-F_(Ciliated)\|356C / Donor, Lineage, Cell class and subclass (all cells)	ANKRD66 TMPRSS4 KLHDC9 DNAH12 VSTM2L GRIN3B	5.80e-05	191	156	6	e314dd8f1a841cab847ae3703bedfe1bc623ac61
ToppCell	IPF-Lymphoid-NK\|World / Disease state, Lineage and Cell class	AOAH APBA2 SH2D2A AXIN1 DIP2A NKG7	5.80e-05	191	156	6	f206159b9d5e84cf14a65bfdc008895cec5a8081
ToppCell	Megakaryocytic-erythropoietic-Megakaryo-cells-Platelet\|Megakaryo-cells / Lineage, cell class and subclass	ZNF438 CARD19 PRDX6 SAT1 SQSTM1 SMOX	5.97e-05	192	156	6	a061db719d87209b56d074afbdeab37aa0079419
ToppCell	nucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-NK\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	AOAH APBA2 SH2D2A AXIN1 DIP2A NKG7	5.97e-05	192	156	6	a06d5d3c2537f8d2b1dc6b6f3e88a80b5c2a1850
ToppCell	CD8+_Memory_T_cell-CV-0\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	HLA-DMA AOAH DGKZ PTPRJ SQSTM1 NKG7	6.14e-05	193	156	6	995781d87a919c0380750878bafe584342bb83ad
ToppCell	COPD-Lymphoid-NK\|Lymphoid / Disease state, Lineage and Cell class	AOAH APBA2 AXIN1 DIP2A PTPN12 NKG7	6.14e-05	193	156	6	0020249fa71afb500af73700543bb6f349be6b10
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-T_cells-TRGV2_gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ACP5 AOAH SH2D2A METTL24 SEC14L6 NKG7	6.32e-05	194	156	6	4b208bb429a1e3d58a9b757b05ef4df85a1e7f1e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HLA-DMA ACP5 AOAH SAT1 FURIN ARAP1	6.50e-05	195	156	6	0ec1b572bbb92b6da3440139366a4c1743b1ad92
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-B\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MAN2B1 HLA-DMA ACP5 AOAH SAT1 DNASE2	6.50e-05	195	156	6	2394e75cf493d8bc2e638ecb425386265176dd41
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.4.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SIGLEC12 HLA-DMA ACP5 RENBP AOC3 DNASE2	6.69e-05	196	156	6	eb7d6bbfb766cdeaf5fe0f0bb66a5f491fd5ef26
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CEMIP FREM2 MEGF8 TRIM9 MRC2 GFPT2	6.69e-05	196	156	6	b8b9801181d7604871b48aebacb295d0a57a5eaf
ToppCell	10x5'-bone_marrow-Lymphocytic_NK-NK_CD16\|bone_marrow / Manually curated celltypes from each tissue	AOAH SH2D2A AXIN1 DIP2A PTPN12 NKG7	6.69e-05	196	156	6	a3b077e82b1550eb328c84b567b60179001f9a77
ToppCell	Fibroblast\|World / shred by cell class for bronchial biopsy	ILK CHRDL2 TGFB1I1 TYRP1 ITGBL1 AOC3	6.88e-05	197	156	6	8bf9846228b6b6721b10375fe54a2fb389ff64a6
ToppCell	wk_15-18-Hematologic-Myeloid-CX3CR1+_Mac\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MAN2B1 WAS HLA-DMA AOAH RENBP SAT1	6.88e-05	197	156	6	701334bc164e3b41132232f27574a87e9c3a5be5
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ILK CHRDL2 TGFB1I1 TYRP1 FREM2 AOC3	6.88e-05	197	156	6	5a63c2b824c7d0dbbc706e408459c9b9fe65daaa
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABCA4 TMPRSS4 DUOX2 SH2D2A NKG7 FOXP3	6.88e-05	197	156	6	9ee927d005eb17843e2516c8006eb192c6ad2af8
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SIGLEC12 MAN2B1 WAS HLA-DMA AOAH SAT1	7.07e-05	198	156	6	dbae6a58cb3ce8612755fbdba6194b70b35f258a
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABCA4 TMPRSS4 DUOX2 SH2D2A NKG7 FOXP3	7.07e-05	198	156	6	3371276410dba693c238b383d990b89371b14d8d
ToppCell	cellseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TMPRSS4 POU3F1 TRIM7 CEMIP IGSF9 FGFR3	7.07e-05	198	156	6	7063d74d79f53d5c59c853a2575f9d3ef12f19ea
ToppCell	Tracheal-10x3prime_v2-Immune_Lymphocytic-T-T_CD8-CD8_GZMK+\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	WAS AOAH APBA2 SH2D2A GRIN2C NKG7	7.07e-05	198	156	6	54bb3d7e6bff9b5919b531417063e68d225c6d1c
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FAT4 AOAH SH2D2A DIP2A PTPN12 NKG7	7.07e-05	198	156	6	1a189b2b213099505c5d871fb8aedd55a97d44e0
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_ILC\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FAT4 AOAH SH2D2A DIP2A PTPN12 NKG7	7.07e-05	198	156	6	716c27d2a37b5f865b9d191e1851917340b400af
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	WASL TM9SF1 ASAP3 SQSTM1 GFPT2 SMOX	7.07e-05	198	156	6	399760b6b6fef8639ded53b14f251b9fce600e81
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SIGLEC12 ACP5 SH2D2A PPP1R3F CYP7B1 FOXP3	7.07e-05	198	156	6	d021d0edb6aba2f15c51a3ec4e08c7233d0c1962
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TMPRSS4 PTPRT FREM2 DUOX1 HEY1 FGFR3	7.07e-05	198	156	6	19d8ff3a4f911b13ecc34844202925475ad4d2ab
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_ILC-NK_cell\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FAT4 AOAH SH2D2A DIP2A PTPN12 NKG7	7.07e-05	198	156	6	b12914c3c5b8dd628cb456cb40283c5016641872
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	OBSCN TMPRSS4 PTPRT CEMIP DUOX1 FGFR3	7.07e-05	198	156	6	5374b0e98d669f36a0571d3c006c7bd5e3c8e87f
ToppCell	distal-mesenchymal-Alveolar_Fibroblast-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ITGBL1 ADRA1B MRC2 AOC3 CYP7B1 GFPT2	7.27e-05	199	156	6	28c1722deef3b8347371c7359be7c64b95780de3
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	OBSCN POU3F1 PTPRT CEMIP DUOX1 FGFR3	7.27e-05	199	156	6	94a7867e800df352731796de8c24cba133c29622
ToppCell	(04)_Interm._basal>secr.\|World / shred by cell type by condition	TMPRSS4 SAT1 HEY1 VSTM2L FGFR3 GALNT4	7.27e-05	199	156	6	ed399244433f781fc291a9bff16825b8a3ca294f
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Platelets\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ILK PRDX6 TGFB1I1 LMAN1L SMOX ATP2A3	7.27e-05	199	156	6	b68648b4559e452656dc9e6a0974233e842f5e0d
ToppCell	Transverse-T_cell-gd_T\|T_cell / Region, Cell class and subclass	HLA-DMA ACP5 AOAH MRC2 VSTM2L NKG7	7.27e-05	199	156	6	8baea162803cea7d72dff5866a0eebfcf2e5dcd6
ToppCell	distal-2-Epithelial-Ciliated\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ANKRD66 KLHDC9 PTPRT DNAH12 VSTM2L GRIN3B	7.27e-05	199	156	6	97b66b82c76c7bc1fcd7da7b94dd2aa2d4d70a60
ToppCell	medial-mesenchymal-Alveolar_Fibroblast\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ITGBL1 ADRA1B MRC2 AOC3 CYP7B1 GFPT2	7.48e-05	200	156	6	c22cbfecee00183dd4be678f116ab9fd9ad0a4dd
ToppCell	distal-2-mesenchymal-Alveolar_Fibroblast\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ITGBL1 ADRA1B MRC2 AOC3 CYP7B1 GFPT2	7.48e-05	200	156	6	12b705dabec1b3752a488a891eda1a5123fcdc41
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD56bright\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	WAS AOAH APBA2 SH2D2A ANGPTL6 NKG7	7.48e-05	200	156	6	1db27223e307efca97502fca40ec5e4f8eea512b
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ATP6AP1 HLA-DMA ACP5 RENBP SAT1 SCART1	7.48e-05	200	156	6	2cca77b2c9d829daa674a844e068f2b083e90d6e
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TYRP1 ITGBL1 MRC2 AOC3 CYP7B1 GFPT2	7.48e-05	200	156	6	8c62f05c6042f24287a73fbdf80ff4a56f7ff403
ToppCell	medial-2-mesenchymal-Alveolar_Fibroblast\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ITGBL1 ADRA1B MRC2 AOC3 CYP7B1 GFPT2	7.48e-05	200	156	6	cc6062dac07916c29091fc6bee2b864d29e6525b
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD3\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	WAS AOAH SH2D2A JAK3 SMG8 NKG7	7.48e-05	200	156	6	6b34f2b85d4f83c1270ee151f602cba6f42042ba
ToppCell	medial-mesenchymal-Alveolar_Fibroblast-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ITGBL1 ADRA1B MRC2 AOC3 CYP7B1 GFPT2	7.48e-05	200	156	6	5c0716bf375c8158f7dc2c82bf5eaf37af594dd0
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD3-NKT\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	WAS AOAH SH2D2A JAK3 SMG8 NKG7	7.48e-05	200	156	6	b2c5618aa1ac19423996336795dadb39ea57cda7
ToppCell	Biopsy_IPF-Mesenchymal-Myofibroblasts\|Biopsy_IPF / Sample group, Lineage and Cell type	FAT4 TYRP1 ITGBL1 MRC2 AOC3 CYP7B1	7.48e-05	200	156	6	c2c6f687c49ba790174b27c7b8b084af30b34c86
ToppCell	LPS-antiTNF-Myeloid-Myeloid_granulocytic\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AOAH PTPRJ ADAM17 ATP2A3 ZMYM5	1.48e-04	143	156	5	4a0f26eef935fe68a1da5d319503059a8a8682dd
ToppCell	LPS-antiTNF-Myeloid-Myeloid_granulocytic-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AOAH PTPRJ ADAM17 ATP2A3 ZMYM5	1.48e-04	143	156	5	65328a0a2f3972fac596e07933e74b2ef7cceb84
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|368C / Donor, Lineage, Cell class and subclass (all cells)	EOGT SH2D2A PTPRJ PPP1R3F FOXP3	1.74e-04	148	156	5	80470353e12599440f711b6e107730763376d04d
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GPR27 ACP5 DIP2A HEY1 NKG7	1.74e-04	148	156	5	065177aaa63c0441d312260b43ecdac78c84ad03
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NPIPB4 NPIPB11 SH2D2A NKG7 SLC41A1	1.80e-04	149	156	5	3378d0fe79de6d7879fd48717ded5027593c785f
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P5-P5_2-Sox4-POLYDENDROCYTE_(Neurogenesis.Sox4.Efhd2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TICRR CHRDL2 KCNE5 UNG	1.97e-04	82	156	4	93b75f8822ffe8870195cd1fe0a7286478f61e79
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4/8-lo-Trm_Tgd\|lymph-node_spleen / Manually curated celltypes from each tissue	KCNE5 SEC14L6 KCNC1 NKG7 GFPT2	2.10e-04	154	156	5	51ffb3fa0250bd31be764ed048728aa064056e16
Drug	N-acetylhexosamine	MAN2C1 MAN2B1 ACP5 NEU3 REG1A RENBP PRDX6 LMAN1L FCSK OVGP1 FURIN AOC3 GFPT2 PCSK4 MUC5AC	7.30e-07	472	153	15	CID000000899
Drug	periodic acid	ATP6AP1 MAN2C1 MAN2B1 WAS ACP5 GBE1 NEU3 PRDX6 LMAN1L MUC5AC	1.32e-06	205	153	10	CID000065185
Drug	argiopine	WAS REG1A GRIN2C GRIN3B	3.35e-06	16	153	4	CID000122294
Drug	Riboflavine [83-88-5]; Up 200; 10.6uM; MCF7; HT_HG-U133A	WDR33 OVGP1 HEY1 FURIN ZNF197 ATP2A3 MUC5AC PIGO ARAP1	8.04e-06	198	153	9	2760_UP
Drug	oxypurinol	DUOX2 LDHA LDHC DUOX1 SQSTM1 NOS1	9.05e-06	72	153	6	CID000004644
Drug	4'-hydroxywogonin	MAN2C1 MAN2B1 NEU3	1.02e-05	7	153	3	CID005322078
Drug	D-G-G	REG1A GRIN2C ANGPTL6 GRIN3B	1.57e-05	23	153	4	CID000444866
Drug	potassium cyanide	HLA-DMA GRIN2C LDHA LDHC PRDX6 AOC3 GRIN3B	1.61e-05	119	153	7	CID000009032
Drug	AC1L96SZ	PIGN MAN2C1 MAN2B1 GFPT2 PIGO	2.13e-05	50	153	5	CID000439166
Drug	Vanadium	ATP6AP1 JAK3 MEGF8 KCNC1 AOC3 ADAM17 ATP2A3 MUC5AC	2.29e-05	173	153	8	ctd:D014639
Drug	Taurine	APAF1 DGKZ DCT LDHC TYRP1 ADRA1B RAPGEF2	2.72e-05	129	153	7	ctd:D013654
Drug	Mefloquine hydrochloride [51773-92-3]; Up 200; 9.6uM; PC3; HT_HG-U133A	OVGP1 SAT1 HEY1 FAM120C SQSTM1 FGGY PIGO ZMYM5	2.81e-05	178	153	8	2048_UP
Drug	ebselen	DUOX2 LDHA LDHC PRDX6 DUOX1 UNG NOS1	3.00e-05	131	153	7	CID000003194
Drug	acetylaminophenylarsine oxide	SAT1 AOC3 SMOX	3.45e-05	10	153	3	CID006337999
Drug	mivazerol	LDHA LDHC ADRA1B	3.45e-05	10	153	3	CID000060783
Drug	C-PP	GRIN2C LDHA LDHC GRIN3B	3.54e-05	28	153	4	CID000001228
Drug	NSC-6354	DUOX2 LDHA LDHC PRDX6 DUOX1 NOS1	3.70e-05	92	153	6	CID000221534
Drug	Furosemide [54-31-9]; Up 200; 12uM; HL60; HG-U133A	GPR27 APBA2 LARP4B PTPN12 SAT1 TRIM9 SEC23IP RAPGEF2	4.82e-05	192	153	8	1580_UP
Drug	Deoxycorticosterone [64-85-7]; Up 200; 12.2uM; HL60; HT_HG-U133A	FAT4 ASAP3 DCT TYRP1 OVGP1 FAM120C GFPT2 ARAP1	5.38e-05	195	153	8	3099_UP
Drug	Dilazep dihydrochloride [20153-98-4]; Up 200; 6uM; HL60; HT_HG-U133A	AXIN1 FURIN GFPT2 SMOX ATP2A3 FGGY DNASE2 FOXP3	5.38e-05	195	153	8	2333_UP
Drug	methylglyoxal bis(guanylhydrazone	ATP6AP1 SAT1 AOC3 UNG SMOX	5.64e-05	61	153	5	CID000009991
Drug	Sulfamethizole [144-82-1]; Down 200; 14.8uM; HL60; HT_HG-U133A	PTPRA FAM120C MRC2 SQSTM1 ADAM17 FGGY PIGO ZMYM5	5.78e-05	197	153	8	2536_DN
Drug	Cefepime hydrochloride [123171-59-5]; Up 200; 7.4uM; MCF7; HT_HG-U133A	GPR27 INTS5 PTPN12 FAM120C MRC2 FURIN ADAM17 ZMYM5	5.78e-05	197	153	8	6237_UP
Drug	1 Tc1	DUOX2 RENBP LDHA LDHC DUOX1 NOS1	5.91e-05	100	153	6	CID000083786
Disease	Wiskott-Aldrich syndrome (implicated_via_orthology)	WASL WAS FOXP3	4.63e-07	4	145	3	DOID:9169 (implicated_via_orthology)
Disease	alpha-Mannosidosis	MAN2C1 MAN2B1	2.40e-05	2	145	2	C0024748
Disease	Autoinflammatory disorder	COPA ACP5 ADAM17 DNASE2	2.60e-05	35	145	4	C3860213
Disease	oculocutaneous albinism (is_implicated_in)	DCT TYRP1	1.43e-04	4	145	2	DOID:0050632 (is_implicated_in)
Disease	phenylketonuria (implicated_via_orthology)	DUOX2 DUOX1	1.43e-04	4	145	2	DOID:9281 (implicated_via_orthology)
Disease	Thoracic Diseases	ILK IFT80	1.43e-04	4	145	2	C0039978
Disease	ribitol measurement	GPBP1L1 FGGY	2.38e-04	5	145	2	EFO_0800143
Disease	Colorectal cancer	PTPN12 PTPRJ FGFR3	3.12e-04	27	145	3	cv:C0346629
Disease	COLORECTAL CANCER	PTPN12 PTPRJ FGFR3	3.12e-04	27	145	3	114500
Disease	Neoplasm of the large intestine	PTPN12 PTPRJ FGFR3	3.12e-04	27	145	3	cv:C0009404
Disease	colorectal cancer (is_implicated_in)	PTPRT PTPN12 PTPRJ FGFR3 FOXP3	3.36e-04	121	145	5	DOID:9256 (is_implicated_in)
Disease	Human papillomavirus infectious disease (is_implicated_in)	FGFR3 FOXP3	3.55e-04	6	145	2	DOID:11166 (is_implicated_in)
Disease	Hyperphosphatasia-intellectual disability syndrome	PIGV PIGO	3.55e-04	6	145	2	cv:C1855923
Disease	trefoil factor 1 measurement	TMPRSS4 MUC5AC	3.55e-04	6	145	2	EFO_0021865
Disease	Cystic kidney	FAT4 IFT80	3.55e-04	6	145	2	C0022679
Disease	Hyperphosphatasia with Mental Retardation	PIGV PIGO	4.96e-04	7	145	2	C1855923
Disease	glucose measurement	AXIN1 LMAN1L MEGF8 PTPRJ PIK3C2G KCNJ11 IFT80 ARAP1	6.06e-04	380	145	8	EFO_0004468
Disease	metastatic colorectal cancer, survival time	AXIN1 HEY1	6.59e-04	8	145	2	EFO_0000714, EFO_1001480
Disease	Industrial Dermatosis	HLA-DMA FOXP3	6.59e-04	8	145	2	C0086457
Disease	Dermatitis, Occupational	HLA-DMA FOXP3	6.59e-04	8	145	2	C0028796
Disease	Osteitis Deformans	NUP205 SQSTM1	8.44e-04	9	145	2	C0029401
Disease	primary bacterial infectious disease (implicated_via_orthology)	DUOX2 DUOX1	8.44e-04	9	145	2	DOID:0050338 (implicated_via_orthology)
Disease	Colon Carcinoma	PTPN12 PTPRJ	8.44e-04	9	145	2	C0699790
Disease	hypertension (biomarker_via_orthology)	LDHA SQSTM1 KCNJ11 ATP2A3 NOS1 FOXP3	9.28e-04	227	145	6	DOID:10763 (biomarker_via_orthology)
Disease	colon cancer (biomarker_via_orthology)	APAF1 REG1A AXIN1	9.33e-04	39	145	3	DOID:219 (biomarker_via_orthology)
Disease	human papilloma virus infection, oral cavity cancer	LDHA LDHC ATP2A3	1.16e-03	42	145	3	EFO_0001668, EFO_0005570
Disease	atopic dermatitis (implicated_via_orthology)	WASL ADAM17	1.28e-03	11	145	2	DOID:3310 (implicated_via_orthology)
Disease	Cystic Kidney Diseases	FAT4 IFT80	1.28e-03	11	145	2	C1691228
Disease	Diabetes Mellitus, Insulin-Dependent	KCNJ11 NOS1 FOXP3	1.42e-03	45	145	3	C0011854
Disease	Carcinoma, Neuroendocrine	TMEM127 MEN1	1.53e-03	12	145	2	C0206695
Disease	hypothyroidism (implicated_via_orthology)	DUOX2 DUOX1	1.81e-03	13	145	2	DOID:1459 (implicated_via_orthology)
Disease	cortisol measurement, response to corticosteroid, response to synacthen	ANKS1B NOS1	1.81e-03	13	145	2	EFO_0005843, EFO_0009175, GO_0031960
Disease	congenital hypothyroidism (implicated_via_orthology)	DUOX2 DUOX1	2.10e-03	14	145	2	DOID:0050328 (implicated_via_orthology)
Disease	myeloid cell surface antigen CD33 measurement	SIGLEC12 NKG7	2.41e-03	15	145	2	EFO_0008238
Disease	Carcinoma of Endocrine Gland	TMEM127 MEN1	2.41e-03	15	145	2	C1704374
Disease	Polydactyly	FREM2 MEGF8 FGFR3 IFT80	2.70e-03	117	145	4	C0152427
Disease	Glycogen storage disease	GBE1 LDHA	3.11e-03	17	145	2	cv:C0017919
Disease	uridine diphosphate galactose measurement, uridine diphosphate glucose measurement	IGFN1 EOGT	3.11e-03	17	145	2	EFO_0010543, EFO_0010544
Disease	phosphatidylcholine 40:6 measurement	PTPRA RAPGEF2	3.11e-03	17	145	2	EFO_0010389
Disease	Familial Progressive Myoclonic Epilepsy	KCNC1 AFG3L2	3.11e-03	17	145	2	C0751777
Disease	Atypical Inclusion-Body Disease	KCNC1 AFG3L2	3.11e-03	17	145	2	C0751776
Disease	Myoclonic Epilepsies, Progressive	KCNC1 AFG3L2	3.11e-03	17	145	2	C0751778
Disease	Biotin-Responsive Encephalopathy	KCNC1 AFG3L2	3.11e-03	17	145	2	C0751780
Disease	May-White Syndrome	KCNC1 AFG3L2	3.11e-03	17	145	2	C0751782
Disease	Dentatorubral-Pallidoluysian Atrophy	KCNC1 AFG3L2	3.11e-03	17	145	2	C0751781
Disease	Action Myoclonus-Renal Failure Syndrome	KCNC1 AFG3L2	3.48e-03	18	145	2	C0751779
Disease	Adenocarcinoma of lung (disorder)	PIGN GRWD1 LDHA FGFR3 CMTR2	3.58e-03	206	145	5	C0152013
Disease	venous thromboembolism, fibrinogen measurement	DIP2B DGKZ PTPRJ	4.42e-03	67	145	3	EFO_0004286, EFO_0004623
Disease	HIV-1 infection, Susceptibility to viral and mycobacterial infections	CYP7B1 ADAM17	4.74e-03	21	145	2	EFO_0000180, Orphanet_391311
Disease	disease of metabolism (implicated_via_orthology)	LDHA LDHC	4.74e-03	21	145	2	DOID:0014667 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EDFVHPGHGDLSGWA	UNG	191	P13051
SHFWGFQTHDVLPDI	AGXT2	331	Q9BYV1
HSLLEGCFPGGVHWV	APAF1	171	O14727
HGAGLTHLLFLPDWA	EOGT	426	Q5NDL2
FGNTDGSPHCVFWDH	ADGRF3	706	Q8IZF5
GSPHCVFWDHSLFQG	ADGRF3	711	Q8IZF5
SWGSAGHDGEPHDLT	ASAP3	411	Q8TDY4
EGIHDSFFEREHPGW	ABCA4	911	P78363
FGEEHSANPFHWDLI	ABCA4	1861	P78363
AGHAVAGWYLEHADP	AFG3L2	576	Q9Y4W6
GHPAPSWVAFAHTGA	DUX4L4	171	P0CJ87
DGHWHTFLIGKNGTA	FAT4	4301	Q6V0I7
VGWTPAHFAAEAGHL	ANKRD66	76	B4E2M5
SWAEEHGVYHPGQSS	CMTR2	466	Q8IYT2
DTGHNTSAPAHWGEL	ADRA1B	6	P35368
WTDSAGPHPHGHEAE	APBA2	141	Q99767
GHPAPSWVAFAHTGA	DUX4L6	171	P0CJ89
EETGFWFIFHHVPTG	CEMIP	691	Q8WUJ3
VWVINIGHFADPAHG	ATP2A3	271	Q93084
IGHFADPAHGGSWLR	ATP2A3	276	Q93084
HNGHITGIDWAPKSD	ARPC1A	51	Q92747
AWVTAGFLHIPHAED	AOC3	676	Q16853
ADHHHRGTDFGGSPW	NPIPB3	46	Q92617
SHPKGFSGWAHLTEV	RASA4	96	O43374
HGAFPVHSQGVWAST	RBAKDN	71	A6NC62
SHPKGFSGWAHLTEV	RASA4B	96	C9J798
IPADSLEWHENLGHG	JAK3	516	P52333
WGSPIGKHHGADDSR	PIK3C2G	126	O75747
QGAGGSPVSWEHFFH	NUP205	546	Q92621
ADHHHRGTDFGGSPW	NPIPB12	46	F8W0I5
HGWVLGEHGDSSVPV	LDHA	186	P00338
LHGDEHLSWFCSPAA	LY6G6F	41	Q5SQ64
ALSEDHAWVVFGPNG	MEN1	181	O00255
GDSAGAHFHISPEWI	AOAH	261	P28039
HDGYHPTSVAEWLDS	ANKS1B	881	Q7Z6G8
LDGPFGEGHQEWHKF	DUOX1	1366	Q9NRD9
FLLLPFHSGWDPDHG	RENBP	286	P51606
RQFHFTSWPDHGVPD	PTPRJ	1196	Q12913
HQPFLHAEGGTAGSW	LCNL1	126	Q6ZST4
GHPAPSWVAFAHTGA	DUX4	171	Q9UBX2
HLWGSHGNSTFPEFL	FOXP3	311	Q9BZS1
DGGSWHVDQRPFVGH	GRWD1	246	Q9BQ67
WHPQDSGVFAASGAD	GRWD1	361	Q9BQ67
DRSADWLGLFAPHHG	NUDT19	71	A8MXV4
TAGDSWHQPSLFRHD	GPBP1L1	61	Q9HC44
WHQPSLFRHDSVDSG	GPBP1L1	66	Q9HC44
LPGAGIPFWSHHGDA	LMAN1L	46	Q9HAT1
IPFWSHHGDAILGLE	LMAN1L	51	Q9HAT1
HEWAPGGALTADAEA	KCNE5	101	Q9UJ90
VFHSPVGVGGWQHFD	FREM2	2681	Q5SZK8
SDSAGIGFRHLPHWN	IL17RE	21	Q8NFR9
AAWEEVAGHHADRGP	LARP4B	81	Q92615
PFGEGHQEWHKFEVS	DUOX2	1366	Q9NRD8
DFHVGAHVNTFWRTP	CPSF1	1301	Q10570
GHPAPSWVAFAHTGA	DUX4L3	171	P0CJ86
WLIAFAHGDLAPSEG	KCNJ11	91	Q14654
PAVSHDWTFHGPGAT	GPR27	221	Q9NS67
HIHIYSASWGPEDDG	PCSK4	251	Q6UW60
LLTGFPGLEAAHHWI	OR51B2	11	Q9Y5P1
PGLEEAHHWISVFFL	OR51B5	16	Q9H339
LYGGPWDVHVHSDLA	FIP1L1	26	Q6UN15
GHEHSSHAWAEVPEG	DCAF5	746	Q96JK2
GDSHLGEIWVNSPHT	DIP2B	1386	Q9P265
FGQFDPVSHEWTDGI	DNAH12	1581	Q6ZR08
PAARHSHVAVAWAGS	MEGF8	276	Q7Z7M0
AAWAQGSTAHHLGPA	POU3F1	126	Q03052
HPTSCHGWIIGEHGD	LDHC	181	P07864
HGWIIGEHGDSSVPL	LDHC	186	P07864
SDGSLVSFTHWHPFE	MRC2	456	Q9UBG0
VLHSPSAHFTGRWDD	MRC2	1081	Q9UBG0
ADHHHRGTDFGGSPW	NPIPB5	46	A8MRT5
PGETWSDAGNHCVTH	MUC5AC	5466	P98088
GNHILPDEDLASFHW	FAM120A	241	Q9NZB2
FRLLAGPHEGHWNVF	CHRDL2	396	Q6WN34
ADHRHRGTDFGGSPW	NPIPA2	46	E9PIF3
ADHHHRGTDFGGSPW	NPIPB4	46	C9JG80
DGEGPIHHGVCSSWL	NOS1	1206	P29475
ELRLFHFTSWPDHGV	PTPRT	1041	O14522
ADHHHRGTDFGGSPW	NPIPB11	46	E5RHQ5
GAGTGELLWDVHSHV	OBSCN	6321	Q5VST9
FELHTWSELPHGSGL	FCSK	826	Q8N0W3
APATWSAHELGHAVG	ADAM30	331	Q9UKF2
FHSGPRGTHDLWDSR	GBE1	311	Q04446
AWAPDGELFAVGSFH	IFT80	236	Q9P2H3
GTRLAWLAEPDAHSH	KCNC1	31	P48547
DHDGGFWLVHSVPNF	DNASE2	121	O00115
FGIAHTRWATHGVPS	GFPT2	86	O94808
FLTVDLHVWPDFHGN	FGGY	381	Q96C11
LEGHDRGVNWAAFHP	COPA	201	P53621
WHFKEDGTIFHPHSG	GALNT4	531	Q8N4A0
HIHIYSASWGPEDDG	FURIN	246	P09958
SFAWGLEPHSHGARS	AXIN1	561	O15169
GHPAPSWVAFAHTGA	DUX4L9	171	Q6RFH8
GNHILPDEDLAAFHW	FAM120C	316	Q9NX05
DDHGFSPLHWACREG	ILK	31	Q13418
PSLSHGSFHTAWGIL	CARD19	181	Q96LW7
WHDHSVPVEGFGPTF	HLA-DMA	161	P28067
HGDAGDSLSWHNDKP	ANGPTL6	381	Q8NI99
GHPAPSWVAFAHTGA	DUX4L7	171	P0CJ90
VAWHIDPFGHSREQA	MAN2B1	191	O00754
PHHTFFWEGLDGSRV	MAN2C1	406	Q9NTJ4
AVIFLHGLGDTGHSW	LYPLA2	26	O95372
GCNLAEPEVAGHWSH	KLHDC9	211	Q8NEP7
EAASGAHAGLGHIPW	HEY1	166	Q9Y5J3
EIGAHHLGFLWASVA	CYP7B1	281	O75881
AVFTRSSAHGPWHEA	IGFN1	1076	Q86VF2
GHQFFPWIHIGDLAG	SDR39U1	186	Q9NRG7
GTMPWGHPGEHHDFE	DGKZ	536	Q13574
LGDSHLGEIWVSSPH	DIP2A	1381	Q14689
GFSHHSAWLVVLPAE	FGFR3	346	P22607
GHPAPSWVAFAHTGA	DUX4L5	171	P0CJ88
HDGEGSPVWYHIVGS	SEC14L6	91	B5MCN3
TCHDVDPTGDWGDIH	ITGBL1	251	O95965
DFWFEAVGPTHSAHS	NKG7	26	Q16617
ADHHHRGTDFGGSPW	NPIPB13	46	A6NJU9
QFHFHGWPEVGIPSD	PTPRA	691	P18433
HGSWERFTGHNSPLF	OVGP1	216	Q12889
SGTDDFNVWIGLHDP	REG1A	91	P05451
GDRAEGSPHFHLEWA	KCTD11	146	Q693B1
EIHLHWPGFEVSGSD	METTL24	296	Q5JXM2
HHPAQGFRFGTVWES	GRIN3B	686	O60391
GGLSLPHAEAHEFWK	SMG8	176	Q8ND04
LLQHGAAPAWFHGFI	SH2D2A	86	Q9NP31
LAGHAAWGIHGVPTS	PRORY	61	Q9H606
HDFLGDSWGILFSHP	PRDX6	26	P30041
LPLDEKGHVTWSFHG	PTPN12	526	Q05209
KGHVTWSFHGPENAI	PTPN12	531	Q05209
TWSAEAHGLAPDGDV	SIRT4	191	Q9Y6E7
FGWIPDGHFSIPHAF	SLC41A1	201	Q8IVJ1
KEHWTPEGHSIVGFA	SAT1	61	P21673
EFLPVHWHSSLGGDA	SEC23IP	496	Q9Y6Y8
PHFDWVVAHIGSSFP	INTS5	221	Q6P9B9
SDPVHGYWFRAGDHV	SIGLEC12	56	Q96PQ1
PFGHLSEGFSHSRWL	SQSTM1	171	Q13501
WQDFFTGHVVGEPDS	ADAM17	111	P78536
HAYEGVPNGGWHTSS	ARAP1	286	Q96P48
SELKHWATFAVGPGH	NEU3	151	Q9UQ49
VEGLLGGLSHWDAEH	PIGV	56	Q9NUD9
QRSWETLPFGHTHFD	RAPGEF2	1266	Q9Y4G8
TEGGHFPLHSPTFSW	WFDC8	6	Q8IUA0
VDFSHEGPAFLTWHR	TYRP1	211	P17643
WVQLHHPGSGEEAVA	ZNF197	101	O14709
HHGGGTVLPSESFSW	TICRR	236	Q7Z2Z1
GFSSGRHHWEVEVGS	TRIM7	391	Q9C029
AFGEWTEIPGAHHII	SMOX	221	Q9NWM0
PEAEEWGSHHGGLQE	TSSC4	266	Q9Y5U2
GGSILDPHWVLTAAH	TMPRSS4	231	Q9NRS4
HVSHVGWDPQNGFDV	WAS	246	P42768
LVAGHYPVWSIAEHG	ACP5	201	P13686
GDAAIWPDAFHCEGT	SCART1	386	Q4G0T1
VRASHDGWASFCDHP	PPP1R3F	181	Q6ZSY5
LWAPAADTHEGHITS	ATP6AP1	56	Q15904
HIPEDDFANGSWVHL	IGSF9	116	Q9P2J2
AIDFSHQGPAFVTWH	DCT	206	P40126
TDWGSHGAGHPSETL	PIGN	266	O95427
SAAAHGAALLSHWDP	UBE2Z	71	Q9H832
AWFAFDPGSAHSDII	TRIM9	536	Q9C026
GLDWHPDSEHILATS	WDR59	196	Q6PJI9
PGHWDADAAEAATAF	WRNIP1	186	Q96S55
NGEFATHHSPDSWIS	ZMYM5	186	Q9UJ78
HWHAAFVGFPEGHGS	PIGO	916	Q8TEQ8
TALGRAWHPEHFVCG	TGFB1I1	241	O43294
HIGHVGWDPNTGFDL	WASL	211	O00401
AVAWHPVHEGLFASG	WDR33	336	Q9C0J8
APWDNHVSGHALFTE	VSTM2L	31	Q96N03
TWKISDVAGPHGDHS	nan	41	Q6ZVU0
ECPGLHTFLLWSHSG	ZNF438	761	Q7Z4V0
TALAEPAWLHIHGGT	TMEM127	46	O75204
EESGFLPHSHKIGLW	TM9SF1	146	O15321
GHPAPSWVAFAHTGA	DUX4L2	171	P0CJ85
GNHRDSWVHGAVDPS	NAALADL1	366	Q9UQQ1
DWSAFAVITSLHPGH	GRIN2C	161	Q14957