Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	diacylglycerol diphosphate phosphatase activity	PLPP5 PLPP4	1.99e-05	3	52	2	GO:0000810
GeneOntologyMolecularFunction	structural constituent of nuclear pore	POM121 NUP214 POM121C	3.68e-05	25	52	3	GO:0017056
GeneOntologyMolecularFunction	nuclear localization sequence binding	POM121 NUP214 POM121C	4.66e-05	27	52	3	GO:0008139
GeneOntologyMolecularFunction	signal sequence binding	POM121 NUP214 POM121C	3.18e-04	51	52	3	GO:0005048
GeneOntologyMolecularFunction	nuclear export signal receptor activity	NUP214 NUP42	4.32e-04	12	52	2	GO:0005049
GeneOntologyMolecularFunction	phosphatidate phosphatase activity	PLPP5 PLPP4	5.93e-04	14	52	2	GO:0008195
GeneOntologyMolecularFunction	lipid phosphatase activity	PLPP5 PLPP4	1.11e-03	19	52	2	GO:0042577
GeneOntologyMolecularFunction	nucleocytoplasmic carrier activity	NUP214 NUP42	3.14e-03	32	52	2	GO:0140142
GeneOntologyMolecularFunction	ATPase activator activity	DNAJB6 DNAJB2	3.14e-03	32	52	2	GO:0001671
GeneOntologyBiologicalProcess	mRNA transport	RGPD2 POM121 ZFP36L1 MCM3AP NUP214 NUP42 POM121C	7.53e-08	145	52	7	GO:0051028
GeneOntologyBiologicalProcess	RNA transport	RGPD2 POM121 ZFP36L1 MCM3AP NUP214 NUP42 POM121C	2.72e-07	175	52	7	GO:0050658
GeneOntologyBiologicalProcess	nucleic acid transport	RGPD2 POM121 ZFP36L1 MCM3AP NUP214 NUP42 POM121C	2.72e-07	175	52	7	GO:0050657
GeneOntologyBiologicalProcess	establishment of RNA localization	RGPD2 POM121 ZFP36L1 MCM3AP NUP214 NUP42 POM121C	3.05e-07	178	52	7	GO:0051236
GeneOntologyBiologicalProcess	RNA localization	RGPD2 POM121 ZFP36L1 MCM3AP NUP214 NUP42 POM121C	1.16e-06	217	52	7	GO:0006403
GeneOntologyBiologicalProcess	nucleobase-containing compound transport	RGPD2 POM121 ZFP36L1 MCM3AP NUP214 NUP42 POM121C	2.89e-06	249	52	7	GO:0015931
GeneOntologyBiologicalProcess	nuclear export	RGPD2 POM121 MCM3AP NUP214 NUP42 POM121C	6.94e-06	185	52	6	GO:0051168
GeneOntologyBiologicalProcess	RNA export from nucleus	POM121 MCM3AP NUP214 POM121C	1.01e-04	96	52	4	GO:0006405
GeneOntologyBiologicalProcess	chorio-allantoic fusion	ZFP36L1 DNAJB6	2.77e-04	10	52	2	GO:0060710
GeneOntologyBiologicalProcess	nuclear transport	RGPD2 POM121 MCM3AP NUP214 NUP42 POM121C	3.64e-04	378	52	6	GO:0051169
GeneOntologyBiologicalProcess	nucleocytoplasmic transport	RGPD2 POM121 MCM3AP NUP214 NUP42 POM121C	3.64e-04	378	52	6	GO:0006913
GeneOntologyBiologicalProcess	negative regulation of inclusion body assembly	DNAJB6 DNAJB2	4.05e-04	12	52	2	GO:0090084
GeneOntologyBiologicalProcess	regulation of glucokinase activity	RGPD2 MIDN	4.78e-04	13	52	2	GO:0033131
GeneOntologyBiologicalProcess	regulation of hexokinase activity	RGPD2 MIDN	5.56e-04	14	52	2	GO:1903299
GeneOntologyBiologicalProcess	labyrinthine layer development	ZFP36L1 HEY1 DNAJB6	5.65e-04	64	52	3	GO:0060711
GeneOntologyCellularComponent	nuclear pore	RGPD2 POM121 MCM3AP NUP214 NUP42 POM121C	2.09e-07	101	53	6	GO:0005643
GeneOntologyCellularComponent	nuclear membrane	RGPD2 POM121 MCM3AP NUP42 POM121C DNAJB2	2.46e-04	349	53	6	GO:0031965
GeneOntologyCellularComponent	nuclear envelope	RGPD2 POM121 MCM3AP NUP214 NUP42 POM121C DNAJB2	5.05e-04	560	53	7	GO:0005635
GeneOntologyCellularComponent	nuclear pore nuclear basket	RGPD2 MCM3AP	9.40e-04	18	53	2	GO:0044615
Domain	-	PLPP5 PLPP4	1.13e-03	18	52	2	1.20.144.10
Domain	acidPPc	PLPP5 PLPP4	1.13e-03	18	52	2	SM00014
Domain	PHD	PHF1 KMT2D MLLT6	1.19e-03	75	52	3	PF00628
Domain	Znf_PHD-finger	PHF1 KMT2D MLLT6	1.39e-03	79	52	3	IPR019787
Domain	P_Acid_Pase_2/haloperoxidase	PLPP5 PLPP4	1.40e-03	20	52	2	IPR000326
Domain	PAP2	PLPP5 PLPP4	1.40e-03	20	52	2	PF01569
Domain	EPHD	KMT2D MLLT6	1.69e-03	22	52	2	PS51805
Domain	PHD	PHF1 KMT2D MLLT6	1.95e-03	89	52	3	SM00249
Domain	Znf_PHD	PHF1 KMT2D MLLT6	2.08e-03	91	52	3	IPR001965
Domain	ZF_PHD_2	PHF1 KMT2D MLLT6	2.35e-03	95	52	3	PS50016
Domain	ZF_PHD_1	PHF1 KMT2D MLLT6	2.42e-03	96	52	3	PS01359
Domain	DnaJ_domain_CS	DNAJB6 DNAJB2	2.55e-03	27	52	2	IPR018253
Domain	Alkaline_phosphatase_core	ARSK ALPP	3.36e-03	31	52	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ARSK ALPP	3.36e-03	31	52	2	IPR017849
Domain	-	ARSK ALPP	3.36e-03	31	52	2	3.40.720.10
Pathway	REACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE	RGPD2 POM121 DNAJB6 NUP214 NUP42 POM121C	4.46e-08	73	39	6	MM14948
Pathway	REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY	RGPD2 POM121 NUP214 NUP42 POM121C	7.62e-08	40	39	5	MM14945
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS	RGPD2 POM121 NUP214 NUP42 POM121C	8.66e-08	41	39	5	MM15200
Pathway	REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS	RGPD2 POM121 NUP214 NUP42 POM121C	9.81e-08	42	39	5	MM15039
Pathway	REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA	RGPD2 POM121 NUP214 NUP42 POM121C	1.11e-07	43	39	5	MM14609
Pathway	REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS	RGPD2 POM121 NUP214 NUP42 POM121C	1.75e-07	47	39	5	MM14939
Pathway	REACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS	RGPD2 POM121 DNAJB6 NUP214 NUP42 POM121C	1.80e-07	92	39	6	MM14951
Pathway	REACTOME_GENE_SILENCING_BY_RNA	RGPD2 POM121 NUP214 NUP42 POM121C	2.17e-07	49	39	5	MM14837
Pathway	REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS	RGPD2 POM121 NUP214 NUP42 POM121C	2.40e-07	50	39	5	MM14610
Pathway	REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS	RGPD2 POM121 NUP214 NUP42 POM121C	2.66e-07	51	39	5	MM15151
Pathway	REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN	RGPD2 POM121 NUP214 NUP42 POM121C	3.91e-07	55	39	5	MM14917
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	RGPD2 POM121 NUP214 NUP42 POM121C	5.11e-07	58	39	5	MM15149
Pathway	REACTOME_SNRNP_ASSEMBLY	RGPD2 POM121 NUP214 NUP42 POM121C	5.11e-07	58	39	5	MM14736
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	RGPD2 POM121 NUP214 NUP42 POM121C	9.09e-07	65	39	5	MM15147
Pathway	REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN	POM121 NUP214 NUP42 POM121C	1.70e-06	32	39	4	M29579
Pathway	REACTOME_EXPORT_OF_VIRAL_RIBONUCLEOPROTEINS_FROM_NUCLEUS	POM121 NUP214 NUP42 POM121C	1.93e-06	33	39	4	M27016
Pathway	REACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN	POM121 NUP214 NUP42 POM121C	2.18e-06	34	39	4	M27041
Pathway	REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS	POM121 NUP214 NUP42 POM121C	2.46e-06	35	39	4	M27320
Pathway	REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA	POM121 NUP214 NUP42 POM121C	2.76e-06	36	39	4	M26974
Pathway	REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY	POM121 NUP214 NUP42 POM121C	2.76e-06	36	39	4	M27245
Pathway	REACTOME_GLUCOSE_METABOLISM	RGPD2 POM121 NUP214 NUP42 POM121C	2.90e-06	82	39	5	MM15394
Pathway	REACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE	POM121 DNAJB6 NUP214 NUP42 POM121C	2.90e-06	82	39	5	M27250
Pathway	REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS	POM121 NUP214 NUP42 POM121C	3.09e-06	37	39	4	M1029
Pathway	REACTOME_INTERACTIONS_OF_REV_WITH_HOST_CELLULAR_PROTEINS	POM121 NUP214 NUP42 POM121C	3.09e-06	37	39	4	M27038
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	RGPD2 POM121 NUP214 NUP42 POM121C	3.27e-06	84	39	5	MM14929
Pathway	REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM	RGPD2 POM121 NUP214 NUP42 POM121C	3.67e-06	86	39	5	MM15413
Pathway	REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS	POM121 NUP214 NUP42 POM121C	3.84e-06	39	39	4	M27238
Pathway	REACTOME_NS1_MEDIATED_EFFECTS_ON_HOST_PATHWAYS	POM121 NUP214 NUP42 POM121C	4.71e-06	41	39	4	M29574
Pathway	REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS	POM121 NUP214 NUP42 POM121C	5.71e-06	43	39	4	M26975
Pathway	REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS	POM121 NUP214 NUP42 POM121C	6.27e-06	44	39	4	M109
Pathway	REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS	POM121 NUP214 NUP42 POM121C	7.51e-06	46	39	4	M27397
Pathway	REACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS	POM121 DNAJB6 NUP214 NUP42 POM121C	8.11e-06	101	39	5	M27253
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	POM121 NUP214 NUP42 POM121C	8.19e-06	47	39	4	M27395
Pathway	REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN	POM121 NUP214 NUP42 POM121C	1.33e-05	53	39	4	M27212
Pathway	REACTOME_SNRNP_ASSEMBLY	POM121 NUP214 NUP42 POM121C	1.43e-05	54	39	4	M29594
Pathway	REACTOME_MITOTIC_PROPHASE	RGPD2 POM121 NUP214 NUP42 POM121C	1.46e-05	114	39	5	MM15361
Pathway	REACTOME_TRNA_PROCESSING_IN_THE_NUCLEUS	POM121 NUP214 NUP42 POM121C	2.04e-05	59	39	4	M27606
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	POM121 NUP214 NUP42 POM121C	4.25e-05	71	39	4	M27394
Pathway	REACTOME_ISG15_ANTIVIRAL_MECHANISM	POM121 NUP214 NUP42 POM121C	5.01e-05	74	39	4	M48006
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	POM121 NUP214 NUP42 POM121C	5.85e-05	77	39	4	M27226
Pathway	REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM	POM121 NUP214 NUP42 POM121C	8.23e-05	84	39	4	M725
Pathway	REACTOME_GLUCOSE_METABOLISM	POM121 NUP214 NUP42 POM121C	8.62e-05	85	39	4	M1870
Pathway	REACTOME_SUMOYLATION	RGPD2 POM121 NUP214 NUP42 POM121C	9.66e-05	169	39	5	MM14919
Pathway	REACTOME_SLC_TRANSPORTER_DISORDERS	POM121 NUP214 NUP42 POM121C	1.56e-04	99	39	4	M27474
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS	POM121 NUP214 NUP42 POM121C	2.03e-04	106	39	4	M27458
Pathway	REACTOME_TRNA_PROCESSING	POM121 NUP214 NUP42 POM121C	2.42e-04	111	39	4	M27684
Pathway	REACTOME_HCMV_LATE_EVENTS	POM121 NUP214 NUP42 POM121C	2.87e-04	116	39	4	M29806
Pathway	REACTOME_SARS_COV_2_ACTIVATES_MODULATES_INNATE_AND_ADAPTIVE_IMMUNE_RESPONSES	POM121 NUP214 NUP42 POM121C	3.93e-04	126	39	4	M45009
Pathway	REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS	POM121 NUP214 NUP42 POM121C	4.55e-04	131	39	4	M5283
Pathway	REACTOME_HCMV_EARLY_EVENTS	POM121 NUP214 NUP42 POM121C	5.54e-04	138	39	4	M29805
Pathway	REACTOME_GENE_SILENCING_BY_RNA	POM121 NUP214 NUP42 POM121C	5.70e-04	139	39	4	M715
Pathway	REACTOME_MITOTIC_PROPHASE	POM121 NUP214 NUP42 POM121C	6.17e-04	142	39	4	M27660
Pathway	REACTOME_HIV_LIFE_CYCLE	POM121 NUP214 NUP42 POM121C	7.39e-04	149	39	4	M4076
Pathway	REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES	POM121 NUP214 NUP42 POM121C	7.77e-04	151	39	4	M550
Pathway	REACTOME_METABOLISM_OF_CARBOHYDRATES	RGPD2 POM121 NUP214 NUP42 POM121C	8.53e-04	271	39	5	MM15406
Pathway	REACTOME_INFLUENZA_INFECTION	POM121 NUP214 NUP42 POM121C	8.99e-04	157	39	4	M4669
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	RGPD2 POM121 NUP214 NUP42 POM121C	9.41e-04	277	39	5	MM15414
Pathway	REACTOME_HCMV_INFECTION	POM121 NUP214 NUP42 POM121C	1.01e-03	162	39	4	M29804
Pathway	REACTOME_SARS_COV_2_INFECTION	POM121 ZDHHC5 NUP214 NUP42 POM121C	1.32e-03	299	39	5	M41727
Pathway	REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS	POM121 NUP214 NUP42 POM121C	1.40e-03	177	39	4	M27476
Pathway	REACTOME_SUMOYLATION	POM121 NUP214 NUP42 POM121C	1.78e-03	189	39	4	M27214
Pathway	REACTOME_POSTMITOTIC_NUCLEAR_PORE_COMPLEX_NPC_REFORMATION	POM121 POM121C	1.98e-03	24	39	2	MM15658
Pathway	REACTOME_SARS_COV_2_HOST_INTERACTIONS	POM121 NUP214 NUP42 POM121C	2.36e-03	204	39	4	M45011
Pathway	REACTOME_CELLULAR_RESPONSES_TO_STIMULI	RGPD2 POM121 DNAJB6 NUP214 NUP42 POM121C	2.45e-03	505	39	6	MM15548
Pathway	KEGG_MEDICUS_REFERENCE_NUCLEAR_EXPORT_OF_MRNA	POM121 NUP214	3.09e-03	30	39	2	M47752
Pathway	WP_PRADERWILLI_AND_ANGELMAN_SYNDROME	POM121 NUP214 NUP42	3.36e-03	109	39	3	M39542
Pathway	REACTOME_HIV_INFECTION	POM121 NUP214 NUP42 POM121C	3.69e-03	231	39	4	M12469
Pathway	KEGG_BUTANOATE_METABOLISM	AACS ALDH3A2	3.96e-03	34	39	2	M3397
Pathway	REACTOME_M_PHASE	RGPD2 POM121 NUP214 NUP42 POM121C	4.06e-03	387	39	5	MM15364
Pathway	REACTOME_RND1_GTPASE_CYCLE	ALDH3A2 PLEKHG5	5.99e-03	42	39	2	M41828
Pathway	REACTOME_RND1_GTPASE_CYCLE	ALDH3A2 PLEKHG5	6.27e-03	43	39	2	MM15679
Pathway	REACTOME_METABOLISM_OF_RNA	RGPD2 POM121 ZFP36L1 NUP214 NUP42 POM121C	6.28e-03	612	39	6	MM15547
Pathway	REACTOME_INTERFERON_SIGNALING	POM121 NUP214 NUP42 POM121C	6.64e-03	273	39	4	M983
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	POM121 NUP214 NUP42 POM121C	7.53e-03	283	39	4	M13087
Pathway	REACTOME_METABOLISM_OF_CARBOHYDRATES	POM121 NUP214 NUP42 POM121C	8.00e-03	288	39	4	M16864
Pathway	REACTOME_SARS_COV_INFECTIONS	POM121 ZDHHC5 NUP214 NUP42 POM121C	9.20e-03	471	39	5	M39009
Pubmed	Peering through the pore: nuclear pore complex structure, assembly, and function.	RGPD2 POM121 NUP214 NUP42 POM121C	3.27e-09	38	53	5	12791264
Pubmed	Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.	RGPD2 POM121 NUP214 POM121C	6.48e-09	15	53	4	14697343
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KMT2D MCM3AP ZDHHC5 FBRSL1 KDM3B MLLT6 NUP214 PUM1 POM121C PLEKHG5 CDC42BPB AHDC1	8.00e-08	1105	53	12	35748872
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	KMT2D POM121 MCM3AP NUP214 NUP42 PUM1 POM121C AHDC1	4.42e-07	457	53	8	32344865
Pubmed	Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase.	PLPP5 PLPP4	2.28e-06	2	53	2	17590538
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	GPBP1L1 ZFP36L1 TELO2 MCM3AP DNAJB6 FBRSL1 KDM3B PUM1 TFCP2 MTFR1L	3.27e-06	1038	53	10	26673895
Pubmed	Probing nuclear pore complex architecture with proximity-dependent biotinylation.	POM121 MCM3AP NUP214 NUP42	5.99e-06	77	53	4	24927568
Pubmed	Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant.	DNAJB6 DNAJB2	6.83e-06	3	53	2	20889486
Pubmed	POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation.	POM121 POM121C	6.83e-06	3	53	2	30802453
Pubmed	Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.	POM121 POM121C	6.83e-06	3	53	2	35507432
Pubmed	Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1.	POM121 NUP214 NUP42	8.47e-06	26	53	3	12228227
Pubmed	A human MAP kinase interactome.	KRT23 POM121 MCM3AP NUP214 NUP42 POM121C CDC42BPB	8.82e-06	486	53	7	20936779
Pubmed	Integrated structural analysis of the human nuclear pore complex scaffold.	POM121 NUP214 NUP42	1.32e-05	30	53	3	24315095
Pubmed	The Structure Inventory of the Nuclear Pore Complex.	POM121 NUP214 NUP42	1.32e-05	30	53	3	27016207
Pubmed	A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1.	NUP214 NUP42	1.36e-05	4	53	2	10358091
Pubmed	Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes.	POM121 POM121C	1.36e-05	4	53	2	17900573
Pubmed	Interaction network of human early embryonic transcription factors.	KMT2D MCM3AP FBRSL1 NUP214 POM121C AHDC1	1.56e-05	351	53	6	38297188
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	POM121 HEY1 MCM3AP ZDHHC5 NUP214 NUP42 ALDH3A2 POM121C TFCP2	1.95e-05	1007	53	9	34597346
Pubmed	Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex.	POM121 NUP42	2.27e-05	5	53	2	9621063
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	PHF1 ZFP36L1 HEY1 ZDHHC5 KDM3B MLLT6 NUP42 TFCP2	2.88e-05	808	53	8	20412781
Pubmed	Functional proteomics mapping of a human signaling pathway.	KMT2D HEY1 MCM3AP CXXC5 KDM3B PUM1 DNAJB2	3.09e-05	591	53	7	15231748
Pubmed	The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human.	NUP214 NUP42	3.40e-05	6	53	2	10228171
Pubmed	Notch activation of Jagged1 contributes to the assembly of the arterial wall.	HEY1 PAX3	3.40e-05	6	53	2	22147907
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	LRIG3 MCM3AP FRMPD1 NUP214 CAMTA1 PUM1	3.57e-05	407	53	6	12693553
Pubmed	A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells.	POM121 MCM3AP NUP214 ALDH3A2	3.58e-05	121	53	4	22412018
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	KLHL24 POM121 MLLT6 NUP214 CAMTA1 POM121C	4.85e-05	430	53	6	35044719
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	POM121 ZDHHC5 NUP42 ALDH3A2 POM121C	5.08e-05	263	53	5	34702444
Pubmed	Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps.	NUP42 AHDC1	8.15e-05	9	53	2	20139417
Pubmed	Antagonistic regulation of p57kip2 by Hes/Hey downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrest.	HEY1 PAX3	1.49e-04	12	53	2	25005473
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PPP4R3B LRIG3 TELO2 FBRSL1 KDM3B PLEKHG5	1.51e-04	529	53	6	14621295
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	MCM3AP ZDHHC5 NUP42 POM121C	1.67e-04	180	53	4	35198878
Pubmed	Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.	ZDHHC5 NUP214 ALDH3A2 POM121C	2.09e-04	191	53	4	31177093
Pubmed	Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants.	HEY1 PAX3	2.36e-04	15	53	2	17194759
Pubmed	Notch pathway targets proangiogenic regulator Sox17 to restrict angiogenesis.	HEY1 ADGRE1	2.36e-04	15	53	2	24755984
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	PPP4R3B GPBP1L1 MCM3AP FBRSL1 NUP42 ALDH3A2	2.66e-04	588	53	6	38580884
Pubmed	Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb.	HEY1 PAX3	2.70e-04	16	53	2	24927569
Pubmed	An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.	HEY1 PAX3	2.70e-04	16	53	2	17273555
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	PPP4R3B TELO2 DNAJB6 NUP214 PUM1 MTFR1L	3.13e-04	606	53	6	36538041
Pubmed	Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway.	HEY1 MUC5AC	3.83e-04	19	53	2	27122169
Pubmed	Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity.	DNAJB6 MMP15 DNAJB2	4.32e-04	96	53	3	34599178
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	PPP4R3B MCM3AP DNAJB6 NUP214 PUM1 POM121C	4.72e-04	655	53	6	35819319
Pubmed	Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.	DNAJB6 DNAJB2 MTFR1L	4.73e-04	99	53	3	29676259
Pubmed	Impaired fetal muscle development and JAK-STAT activation mark disease onset and progression in a mouse model for merosin-deficient congenital muscular dystrophy.	HEY1 PAX3	5.16e-04	22	53	2	28334989
Pubmed	Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature.	DNAJB6 DNAJB2	5.16e-04	22	53	2	11147971
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	POM121 TELO2 NUP214 ALDH3A2 PUM1 POM121C DNAJB2	5.45e-04	942	53	7	31073040
Pubmed	The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities.	DNAJB6 DNAJB2	5.65e-04	23	53	2	21231916
Pubmed	Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase.	NUP214 NUP42	6.68e-04	25	53	2	10601273
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	PPP4R3B HEY1 TTLL5 CXXC5 NUP42 UBASH3A DNAJB2 CDC42BPB	6.87e-04	1285	53	8	35914814
Pubmed	Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.	HEY1 MUC5AC	7.80e-04	27	53	2	21791528
Pubmed	Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions.	PAX3 CDC42BPB	8.40e-04	28	53	2	35942939
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	NUP214 NUP42 POM121C	8.89e-04	123	53	3	26912792
Pubmed	The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing.	POM121 POM121C	9.01e-04	29	53	2	17577209
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	POM121 COL27A1 ZDHHC5 POM121C CDC42BPB	9.19e-04	493	53	5	15368895
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	PHF1 KMT2D DNAJB6 FBRSL1 AHDC1	9.36e-04	495	53	5	27705803
Pubmed	iRhom2 mutation leads to aberrant hair follicle differentiation in mice.	HEY1 ADGRE1	9.64e-04	30	53	2	25546423
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PPP4R3B KMT2D TELO2 ZDHHC5 ALDH3A2 PUM1 CDC42BPB	1.02e-03	1049	53	7	27880917
Pubmed	The NANCI-Nkx2.1 gene duplex buffers Nkx2.1 expression to maintain lung development and homeostasis.	ADGRE1 MUC5AC	1.10e-03	32	53	2	28546511
Pubmed	The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways.	HEY1 MUC5AC	1.17e-03	33	53	2	23213461
Pubmed	Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo.	PAX3 NUP214	1.24e-03	34	53	2	18539113
Pubmed	Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s).	POM121 POM121C	1.31e-03	35	53	2	11013070
Pubmed	Human transcription factor protein interaction networks.	KMT2D MIDN FBRSL1 MLLT6 NUP214 PUM1 POM121C TFCP2	1.36e-03	1429	53	8	35140242
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	RGPD2 CXXC5 PUM1	1.46e-03	146	53	3	23892456
Pubmed	Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling.	KRT23 HEY1	1.47e-03	37	53	2	22432025
Pubmed	Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.	ZFP36L1 UBASH3A	1.47e-03	37	53	2	19430480
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	KRT23 KMT2D TTLL5 KDM3B POM121C	1.52e-03	552	53	5	10737800
Interaction	APC interactions	KRT23 POM121 HEY1 TELO2 MCM3AP NUP214 NUP42 POM121C	7.44e-06	389	53	8	int:APC
Interaction	NUP35 interactions	KMT2D POM121 MCM3AP NUP214 NUP42 PUM1 POM121C AHDC1	1.39e-05	424	53	8	int:NUP35
Cytoband	5q15	KIAA0825 ARSK	9.92e-04	40	53	2	5q15
Cytoband	Ensembl 112 genes in cytogenetic band chr5q15	KIAA0825 ARSK	2.15e-03	59	53	2	chr5q15
GeneFamily	Phospholipid phosphatases	PLPP5 PLPP4	8.04e-05	7	36	2	1067
GeneFamily	PHD finger proteins	PHF1 KMT2D MLLT6	7.56e-04	90	36	3	88
GeneFamily	Nucleoporins	POM121 NUP214	1.84e-03	32	36	2	1051
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJB6 DNAJB2	4.27e-03	49	36	2	584
Disease	transmembrane glycoprotein NMB measurement	PAX3 NUP42	1.41e-04	10	53	2	EFO_0008303
Disease	facial hair thickness measurement	PLPP4 PAX3	1.52e-03	32	53	2	EFO_0007823
Disease	Huntington's disease (implicated_via_orthology)	DNAJB6 DNAJB2	1.52e-03	32	53	2	DOID:12858 (implicated_via_orthology)
Disease	COVID-19 symptoms measurement	FBRSL1 MUC5AC	1.81e-03	35	53	2	EFO_0600019
Disease	Inherited neuropathies	ALDH3A2 DNAJB2	2.36e-03	40	53	2	C0598589
Disease	Charcot-Marie-Tooth disease	MCM3AP DNAJB2	2.60e-03	42	53	2	cv:C0007959
Disease	neuroimaging measurement	ZDHHC5 CXXC5 SLC12A8 PAX3 CAMTA1 POM121C TFCP2	2.89e-03	1069	53	7	EFO_0004346

Protein segments in the cluster

Peptide	Gene	Start	Entry
PSPSSGENFGSSTFH	ARSK	211	Q6UWY0
PSTFGGLGSLSSHAF	FBRSL1	686	Q9HCM7
AGSTFSLPSTHIFGT	MLLT6	616	P55198
SSDGHKFAFPTTGSS	CAMTA1	436	Q9Y6Y1
FSHPLFIMFSSGTTG	AACS	281	Q86V21
HFTLNSFPFGGVGSS	ALDH3A2	391	P51648
SFFSSSEGAPFSGSA	AHDC1	1036	Q5TGY3
HLGFPTSASAAASGY	AHDC1	1246	Q5TGY3
GHSFDSNSFGPVSLG	IMMP2L	126	Q96T52
HTGNTGSEAAFSPSF	INPP1	246	P49441
SVSFPSTLSGTSFHF	KIAA0825	126	Q8IV33
SGAGFFLPQHDSSGT	LRIG3	886	Q6UXM1
PAAAFSAAFTSPGSH	GPBP1L1	206	Q9HC44
FASGFHGDSSPFDGT	MMP15	201	P51511
GSTFSPFTGPNFDHT	TMPRSS15	371	P98073
IASGFFTFSHPISSA	MCM3AP	171	O60318
GSPGIAASFHSAVFS	INHBE	286	P58166
DTPHSISFSGSGFLS	PNPLA1	11	Q8N8W4
SNVFGRHSGGFLSSP	KDM3B	766	Q7LBC6
SFSQTPSASFHGAGG	KRT23	6	Q9C075
PSAASFSFGSSGFKP	NUP214	541	P35658
SKPFSFSPSGTGFNF	NUP214	1211	P35658
LPCFGSSFHSTTSFV	MTFR1L	171	Q9H019
PGTCSVLGGAHFSTF	MUC5AC	431	P98088
FSGLHLPFIGFTFTT	CDC42BPB	391	Q9Y5S2
RTSPGGFKFTFSHSA	PPP4R3B	766	Q5MIZ7
SFPSIHSSFAFSGLG	PLPP4	141	Q5VZY2
SRPLSHYSSFGSSGG	CXXC5	76	Q7LFL8
FSFKSPAASSFGSPG	NUP42	301	O15504
PIGHSFYNGLSFSSS	PUM1	726	Q14671
HGFSSYTDSFVPPSG	PAX3	361	P23760
PSFGSSFTFGNSAAP	POM121C	966	A8CG34
SHVFSFGGYPLRGSS	ALPP	381	P05187
ALAPSFGSSFTFGNS	POM121	986	Q96HA1
FTSFGSLGHGGLTSF	DNAJB6	161	O75190
PKSLTGHEFFDFSSG	KLHL24	31	Q6TFL4
SRHSGPFFTFSSSFP	DNAJB2	131	P25686
PFFTFSSSFPGHSDF	DNAJB2	136	P25686
GHSDFSSSSFSFSPG	DNAJB2	146	P25686
SSSSFSFSPGAGAFR	DNAJB2	151	P25686
SSSRSTFFHFGSPGL	FRMPD1	621	Q5SYB0
STSFPIKGTHFSDSF	CENPJ	51	Q9HC77
SSGYSIFHLAGSTPF	COL27A1	606	Q8IZC6
LSAFPFSFGSFHLLS	HEY1	261	Q9Y5J3
PGLHLGSASNFSFFR	SLC12A8	636	A0AV02
FASFHPSASTAGTSG	PHF1	451	O43189
SFVNHAPGVFSGTFS	MIDN	271	Q504T8
SATGSLFGFSFNAPL	RGPD2	1556	P0DJD1
AGSPSRFNSVAGHFF	TELO2	686	Q9Y4R8
PGFESSSGHLSFQGL	ADGRE1	201	Q14246
AASRFSGFFSSGPST	PLEKHG5	246	O94827
SFSFAGFPSAAATAA	ZFP36L1	201	Q07352
SPGFNSSHSSFSLGE	TFCP2	291	Q12800
KSFPSGHSSFAFAGL	PLPP5	146	Q8NEB5
GSARFASHATFSLSG	SMTNL2	116	Q2TAL5
TFGKSFHFDPLSSGS	ZDHHC5	411	Q9C0B5
GSHTIGPFSSFQSAA	TTLL5	966	Q6EMB2
HSSISYLGFFVSGSP	UBASH3A	151	P57075
GPFSSSGHTAEKASF	KMT2D	3171	O14686