Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	extracellular matrix structural constituent	COL23A1 COL13A1 COL21A1 COL22A1 COLQ SSPOP AGRN TNXB	1.50e-07	188	64	8	GO:0005201
GeneOntologyMolecularFunction	extracellular matrix structural constituent conferring tensile strength	COL23A1 COL13A1 COL21A1 COL22A1 COLQ	3.57e-07	46	64	5	GO:0030020
GeneOntologyMolecularFunction	glycosaminoglycan binding	COL23A1 CFH COL13A1 LGR6 COLQ AGRN TNXB CFHR3	2.19e-06	268	64	8	GO:0005539
GeneOntologyMolecularFunction	heparin binding	COL23A1 CFH COL13A1 LGR6 COLQ TNXB CFHR3	2.66e-06	192	64	7	GO:0008201
GeneOntologyMolecularFunction	sulfur compound binding	COL23A1 CFH COL13A1 LGR6 COLQ AGRN TNXB CFHR3	8.66e-06	323	64	8	GO:1901681
GeneOntologyMolecularFunction	SH3 domain binding	DRD4 AFAP1L2 EFS ADAM15 SOCS7	9.53e-05	143	64	5	GO:0017124
GeneOntologyMolecularFunction	structural molecule activity	COL23A1 KRT72 COL13A1 COL21A1 OBSCN COL22A1 COLQ SSPOP AGRN TNXB KRT36	1.12e-04	891	64	11	GO:0005198
GeneOntologyMolecularFunction	complement binding	CFH CR2 CFHR3	1.46e-04	32	64	3	GO:0001848
GeneOntologyMolecularFunction	hormone binding	DRD4 GALR2 CCKAR PGR	3.34e-04	103	64	4	GO:0042562
GeneOntologyMolecularFunction	complement component C3b binding	CFH CFHR3	6.54e-04	12	64	2	GO:0001851
GeneOntologyMolecularFunction	steroid binding	NPC1 IRX5 NPC2 PGR	8.77e-04	133	64	4	GO:0005496
GeneOntologyMolecularFunction	titin binding	CAMK2D OBSCN	8.98e-04	14	64	2	GO:0031432
GeneOntologyMolecularFunction	immunoglobulin receptor binding	ADAM15 CR2	2.04e-03	21	64	2	GO:0034987
GeneOntologyCellularComponent	extracellular matrix	COL23A1 COL13A1 FCGBP COL21A1 ADAMTS20 LINGO3 MUC5B COL22A1 LGR6 EGFL7 COLQ SSPOP AGRN TNXB IGFBPL1	7.27e-10	656	63	15	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	COL23A1 COL13A1 FCGBP COL21A1 ADAMTS20 LINGO3 MUC5B COL22A1 LGR6 EGFL7 COLQ SSPOP AGRN TNXB IGFBPL1	7.58e-10	658	63	15	GO:0030312
GeneOntologyCellularComponent	collagen-containing extracellular matrix	COL23A1 COL13A1 COL21A1 ADAMTS20 COL22A1 EGFL7 COLQ SSPOP AGRN TNXB IGFBPL1	4.69e-07	530	63	11	GO:0062023
GeneOntologyCellularComponent	collagen trimer	COL23A1 COL13A1 COL21A1 COL22A1 COLQ	6.84e-06	88	63	5	GO:0005581
GeneOntologyCellularComponent	endoplasmic reticulum lumen	COL23A1 COL13A1 COL21A1 TMEM132A COL22A1 ARSG	4.87e-04	332	63	6	GO:0005788
HumanPheno	Low cholesterol esterification rate	NPC1 NPC2	2.13e-05	2	24	2	HP:0003349
HumanPheno	Decreased size of nerve terminals	COL13A1 COLQ AGRN	4.03e-05	15	24	3	HP:0003443
HumanPheno	CNS foam cells	NPC1 NPC2	6.36e-05	3	24	2	HP:0003640
HumanPheno	Decreased circulating complement factor H concentration	CFH CFHR3	1.27e-04	4	24	2	HP:0005369
HumanPheno	Anti-acetylcholine receptor antibody positivity	COL13A1 COLQ AGRN	1.33e-04	22	24	3	HP:6001064
HumanPheno	Anti-neuromuscular Junction acetylcholine receptor antibody positivity	COL13A1 COLQ AGRN	1.33e-04	22	24	3	HP:0030208
HumanPheno	Decreased circulating complement factor I concentration	CFH CFHR3	2.11e-04	5	24	2	HP:0005356
HumanPheno	Sea-blue histiocytosis	NPC1 NPC2	2.11e-04	5	24	2	HP:0001982
HumanPheno	Bone-marrow foam cells	NPC1 NPC2	2.11e-04	5	24	2	HP:0004333
HumanPheno	Decreased circulating complement factor B concentration	CFH CFHR3	2.11e-04	5	24	2	HP:0005416
HumanPheno	Abnormality of histiocytes	NPC1 NPC2	2.11e-04	5	24	2	HP:0004310
HumanPheno	Muscle fiber atrophy	COL13A1 OBSCN COLQ AGRN	2.38e-04	67	24	4	HP:0100295
HumanPheno	Decreased urine output	CFH OBSCN CFHR3	3.43e-04	30	24	3	HP:0011037
HumanPheno	EMG: decremental response of compound muscle action potential to repetitive nerve stimulation	COL13A1 COLQ AGRN	3.43e-04	30	24	3	HP:0003403
HumanPheno	Abnormality of jaw muscles	COL13A1 OBSCN AGRN	3.79e-04	31	24	3	HP:0045037
HumanPheno	Macular hemorrhage	CFH CFHR3	4.40e-04	7	24	2	HP:0025574
HumanPheno	Abnormal muscle fiber-type distribution	COL13A1 OBSCN COLQ AGRN	5.43e-04	83	24	4	HP:0033684
HumanPheno	Macular drusen	CFH CFHR3	5.86e-04	8	24	2	HP:0030499
HumanPheno	Fetal ascites	NPC1 NPC2	5.86e-04	8	24	2	HP:0001791
HumanPheno	EMG: impaired neuromuscular transmission	COL13A1 COLQ AGRN	5.93e-04	36	24	3	HP:0100285
Domain	Unchr_dom_Cys-rich	FCGBP KCP MUC5B SSPOP	8.21e-08	13	63	4	IPR014853
Domain	C8	FCGBP KCP MUC5B SSPOP	8.21e-08	13	63	4	SM00832
Domain	TIL_dom	FCGBP KCP MUC5B SSPOP	1.15e-07	14	63	4	IPR002919
Domain	VWC	FCGBP PXDNL KCP MUC5B SSPOP	1.71e-07	38	63	5	SM00214
Domain	VWD	FCGBP KCP MUC5B SSPOP	2.07e-07	16	63	4	SM00216
Domain	VWF_type-D	FCGBP KCP MUC5B SSPOP	2.07e-07	16	63	4	IPR001846
Domain	VWFD	FCGBP KCP MUC5B SSPOP	2.07e-07	16	63	4	PS51233
Domain	VWD	FCGBP KCP MUC5B SSPOP	2.07e-07	16	63	4	PF00094
Domain	VWF_dom	FCGBP PXDNL KCP MUC5B SSPOP	2.87e-07	42	63	5	IPR001007
Domain	VWC_out	FCGBP KCP MUC5B SSPOP	4.39e-07	19	63	4	SM00215
Domain	VWFC_1	PXDNL KCP MUC5B SSPOP	6.38e-06	36	63	4	PS01208
Domain	TIL	FCGBP MUC5B SSPOP	7.87e-06	12	63	3	PF01826
Domain	C8	FCGBP MUC5B SSPOP	7.87e-06	12	63	3	PF08742
Domain	VWFC_2	PXDNL KCP MUC5B SSPOP	7.96e-06	38	63	4	PS50184
Domain	Collagen	COL23A1 COL13A1 COL21A1 COL22A1 COLQ	9.90e-06	85	63	5	IPR008160
Domain	Collagen	COL23A1 COL13A1 COL21A1 COL22A1 COLQ	9.90e-06	85	63	5	PF01391
Domain	EGF_3	ADAM15 EGFL7 SSPOP AGRN TNXB NOTCH3 NOTCH4	1.39e-05	235	63	7	PS50026
Domain	EGF	FCGBP ADAM15 EGFL7 AGRN TNXB NOTCH3 NOTCH4	1.39e-05	235	63	7	SM00181
Domain	EGF-like_dom	FCGBP ADAM15 EGFL7 AGRN TNXB NOTCH3 NOTCH4	2.02e-05	249	63	7	IPR000742
Domain	EGF_1	ADAM15 EGFL7 SSPOP AGRN TNXB NOTCH3 NOTCH4	2.35e-05	255	63	7	PS00022
Domain	EGF_2	ADAM15 EGFL7 SSPOP AGRN TNXB NOTCH3 NOTCH4	3.00e-05	265	63	7	PS01186
Domain	EGF_extracell	ADAM15 EGFL7 TNXB NOTCH3	4.97e-05	60	63	4	IPR013111
Domain	EGF_2	ADAM15 EGFL7 TNXB NOTCH3	4.97e-05	60	63	4	PF07974
Domain	Notch	NOTCH3 NOTCH4	6.69e-05	4	63	2	IPR008297
Domain	NODP	NOTCH3 NOTCH4	6.69e-05	4	63	2	PF07684
Domain	Notch_NODP_dom	NOTCH3 NOTCH4	6.69e-05	4	63	2	IPR011656
Domain	Notch_NOD_dom	NOTCH3 NOTCH4	6.69e-05	4	63	2	IPR010660
Domain	NOD	NOTCH3 NOTCH4	6.69e-05	4	63	2	PF06816
Domain	NOD	NOTCH3 NOTCH4	6.69e-05	4	63	2	SM01338
Domain	NODP	NOTCH3 NOTCH4	6.69e-05	4	63	2	SM01339
Domain	LNR	NOTCH3 NOTCH4	1.11e-04	5	63	2	PS50258
Domain	VWC	PXDNL KCP MUC5B	1.13e-04	28	63	3	PF00093
Domain	Growth_fac_rcpt_	EGFL7 TNXB IGFBPL1 NOTCH3 NOTCH4	1.81e-04	156	63	5	IPR009030
Domain	Notch_dom	NOTCH3 NOTCH4	2.33e-04	7	63	2	IPR000800
Domain	Notch	NOTCH3 NOTCH4	2.33e-04	7	63	2	PF00066
Domain	NL	NOTCH3 NOTCH4	2.33e-04	7	63	2	SM00004
Domain	EGF-like_CS	ADAM15 EGFL7 AGRN TNXB NOTCH3 NOTCH4	2.45e-04	261	63	6	IPR013032
Domain	LRRNT	PXDNL PKD1 LINGO3 LGR6	3.35e-04	98	63	4	IPR000372
Domain	LRRNT	PXDNL PKD1 LINGO3 LGR6	3.35e-04	98	63	4	SM00013
Domain	LDLRA_1	PKD1 CD320 SSPOP	5.68e-04	48	63	3	PS01209
Domain	LDLRA_2	PKD1 CD320 SSPOP	6.03e-04	49	63	3	PS50068
Domain	Fol_N	FCGBP AGRN	6.04e-04	11	63	2	IPR003645
Domain	FOLN	FCGBP AGRN	6.04e-04	11	63	2	SM00274
Domain	Sushi	CFH CR2 CFHR3	7.18e-04	52	63	3	PF00084
Domain	LRRNT	PKD1 LINGO3 LGR6	7.60e-04	53	63	3	PF01462
Domain	EGF_CA	EGFL7 AGRN NOTCH3 NOTCH4	7.67e-04	122	63	4	SM00179
Domain	CCP	CFH CR2 CFHR3	8.03e-04	54	63	3	SM00032
Domain	EGF-like_Ca-bd_dom	EGFL7 AGRN NOTCH3 NOTCH4	8.15e-04	124	63	4	IPR001881
Domain	EGF	AGRN TNXB NOTCH3 NOTCH4	8.65e-04	126	63	4	PF00008
Domain	SUSHI	CFH CR2 CFHR3	8.93e-04	56	63	3	PS50923
Domain	Sushi_SCR_CCP_dom	CFH CR2 CFHR3	9.40e-04	57	63	3	IPR000436
Domain	Laminin_G	COL21A1 COL22A1 AGRN	9.89e-04	58	63	3	IPR001791
Domain	EMI	EGFL7 SSPOP	1.47e-03	17	63	2	PS51041
Domain	CTCK_1	MUC5B SSPOP	1.65e-03	18	63	2	PS01185
Domain	Kazal_1	AGRN IGFBPL1	2.48e-03	22	63	2	PF00050
Domain	LRR_8	PXDNL PKD1 LINGO3 LGR6	2.65e-03	171	63	4	PF13855
Domain	TSPN	COL21A1 COL22A1	2.71e-03	23	63	2	SM00210
Domain	Leu-rich_rpt_typical-subtyp	PXDNL PKD1 LINGO3 LGR6	3.01e-03	177	63	4	IPR003591
Domain	LRR_TYP	PXDNL PKD1 LINGO3 LGR6	3.01e-03	177	63	4	SM00369
Domain	EGF_CA	EGFL7 NOTCH3 NOTCH4	3.07e-03	86	63	3	PF07645
Domain	Cys_knot_C	MUC5B SSPOP	3.20e-03	25	63	2	IPR006207
Domain	CTCK_2	MUC5B SSPOP	3.20e-03	25	63	2	PS01225
Domain	Cys-rich_flank_reg_C	PXDNL PKD1 LINGO3	3.49e-03	90	63	3	IPR000483
Domain	LRRCT	PXDNL PKD1 LINGO3	3.49e-03	90	63	3	SM00082
Domain	Ig_I-set	PXDNL OBSCN LINGO3 IGFBPL1	3.87e-03	190	63	4	IPR013098
Domain	I-set	PXDNL OBSCN LINGO3 IGFBPL1	3.87e-03	190	63	4	PF07679
Domain	hEGF	NOTCH3 NOTCH4	4.00e-03	28	63	2	PF12661
Domain	EGF_Ca-bd_CS	EGFL7 NOTCH3 NOTCH4	4.30e-03	97	63	3	IPR018097
Domain	EGF_CA	EGFL7 NOTCH3 NOTCH4	4.56e-03	99	63	3	PS01187
Domain	ASX_HYDROXYL	EGFL7 NOTCH3 NOTCH4	4.69e-03	100	63	3	PS00010
Domain	LRR	PXDNL PKD1 LINGO3 LGR6	4.73e-03	201	63	4	PS51450
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTS20 MUC5B SSPOP NOTCH3 NOTCH4	2.65e-06	68	46	5	M27303
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	ADAMTS20 MUC5B SSPOP AGRN NOTCH3 NOTCH4	6.58e-06	143	46	6	M27275
Pathway	REACTOME_COLLAGEN_CHAIN_TRIMERIZATION	COL23A1 COL13A1 COL21A1 COL22A1	1.22e-05	44	46	4	M27812
Pathway	REACTOME_DISEASES_OF_METABOLISM	ADAMTS20 MUC5B CD320 SSPOP AGRN NOTCH3 NOTCH4	1.50e-05	250	46	7	M27554
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	COL23A1 COL13A1 COL21A1 ADAM15 COL22A1 AGRN TNXB	4.84e-05	300	46	7	M610
Pathway	KEGG_DORSO_VENTRAL_AXIS_FORMATION	FMN2 NOTCH3 NOTCH4	6.27e-05	24	46	3	M11190
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL23A1 COL13A1 COL21A1 COL22A1	6.54e-05	67	46	4	M26999
Pathway	REACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3	NOTCH3 NOTCH4	1.04e-04	5	46	2	M27411
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI	NOTCH3 NOTCH4	1.04e-04	5	46	2	MM14733
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_CFHR	CFH CFHR3	1.55e-04	6	46	2	M47880
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM	NOTCH3 NOTCH4	1.55e-04	6	46	2	M27068
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	COL23A1 COL13A1 ADAM15 COL22A1 AGRN TNXB	1.80e-04	258	46	6	MM14572
Pathway	REACTOME_COLLAGEN_FORMATION	COL23A1 COL13A1 COL21A1 COL22A1	2.07e-04	90	46	4	M631
Pathway	REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING	NOTCH3 NOTCH4	2.16e-04	7	46	2	MM14734
Pathway	WP_NEURAL_CREST_DIFFERENTIATION	OLIG3 ZIC5 NOTCH3 NOTCH4	2.75e-04	97	46	4	MM15926
Pathway	REACTOME_COLLAGEN_CHAIN_TRIMERIZATION	COL23A1 COL13A1 COL22A1	3.18e-04	41	46	3	MM15538
Pathway	WP_NEURAL_CREST_DIFFERENTIATION	OLIG3 ZIC5 NOTCH3 NOTCH4	3.22e-04	101	46	4	M39448
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION	NOTCH3 NOTCH4	5.62e-04	11	46	2	M47865
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380	NOTCH3 NOTCH4	6.73e-04	12	46	2	M47532
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381	NOTCH3 NOTCH4	6.73e-04	12	46	2	M47533
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY	NOTCH3 NOTCH4	7.94e-04	13	46	2	M47423
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382	NOTCH3 NOTCH4	7.94e-04	13	46	2	M47534
Pathway	PID_NOTCH_PATHWAY	SSPOP NOTCH3 NOTCH4	9.30e-04	59	46	3	M17
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL23A1 COL13A1 COL22A1	1.03e-03	61	46	3	MM14637
Pathway	WP_DEGRADATION_PATHWAY_OF_SPHINGOLIPIDS_INCLUDING_DISEASES	NPC1 NPC2	1.37e-03	17	46	2	M39638
Pathway	REACTOME_LDL_CLEARANCE	NPC1 NPC2	1.54e-03	18	46	2	MM15565
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI	NOTCH3 NOTCH4	1.54e-03	18	46	2	M614
Pathway	REACTOME_LDL_CLEARANCE	NPC1 NPC2	1.72e-03	19	46	2	M27846
Pathway	REACTOME_COLLAGEN_FORMATION	COL23A1 COL13A1 COL22A1	1.94e-03	76	46	3	MM14573
Pathway	REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY	NOTCH3 NOTCH4	2.52e-03	23	46	2	MM14954
Pathway	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	COL23A1 COL13A1 AGRN	2.66e-03	85	46	3	M16441
Pathway	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE	KRT72 CDSN KRT36	2.85e-03	87	46	3	MM15351
Pathway	WP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING	NOTCH3 NOTCH4	3.47e-03	27	46	2	M39545
Pathway	WP_7OXOC_AND_7BETAHC_PATHWAYS	NPC1 NPC2	3.47e-03	27	46	2	M40054
Pathway	REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY	NOTCH3 NOTCH4	3.73e-03	28	46	2	M6177
Pubmed	Genome-wide association study for serum complement C3 and C4 levels in healthy Chinese subjects.	CFH TNXB NOTCH4 CFHR3	2.44e-08	17	64	4	23028341
Pubmed	Loss of function of the maternal membrane oestrogen receptor ERα alters expansion of trophoblast cells and impacts mouse fertility.	EGFL7 NOTCH3 NOTCH4 PGR	8.99e-08	23	64	4	36239412
Pubmed	Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal.	EGFL7 NOTCH3 NOTCH4	1.18e-07	6	64	3	19503073
Pubmed	Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.	CFH TNXB NOTCH4	3.31e-07	8	64	3	22694956
Pubmed	Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.	COL23A1 COL13A1 COL21A1 EGFL7 COLQ TNXB	3.99e-07	153	64	6	25037231
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NPC1 CCDC71L RHPN1 TMEM132A PKD1 SEC16A OBSCN AGRN HOXB13 ARSG BAHCC1 HR	7.14e-07	1105	64	12	35748872
Pubmed	Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2.	NPC1 NPC2	3.33e-06	2	64	2	32544384
Pubmed	The subcellular localization of the Niemann-Pick Type C proteins depends on the adaptor complex AP-3.	NPC1 NPC2	3.33e-06	2	64	2	17895371
Pubmed	The Niemann-Pick C proteins and trafficking of cholesterol through the late endosomal/lysosomal system.	NPC1 NPC2	3.33e-06	2	64	2	12125814
Pubmed	Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions.	NPC1 NPC2	3.33e-06	2	64	2	26846330
Pubmed	Loss of Niemann Pick type C proteins 1 and 2 greatly enhances HIV infectivity and is associated with accumulation of HIV Gag and cholesterol in late endosomes/lysosomes.	NPC1 NPC2	3.33e-06	2	64	2	22273177
Pubmed	Loss of Niemann-Pick C1 or C2 protein results in similar biochemical changes suggesting that these proteins function in a common lysosomal pathway.	NPC1 NPC2	3.33e-06	2	64	2	21887293
Pubmed	Physiological and coordinate downregulation of the NPC1 and NPC2 genes are associated with the sequestration of LDL-derived cholesterol within endocytic compartments.	NPC1 NPC2	3.33e-06	2	64	2	19746448
Pubmed	Niemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding.	NPC1 NPC2	3.33e-06	2	64	2	22065762
Pubmed	Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted mice.	NOTCH3 NOTCH4	3.33e-06	2	64	2	33665264
Pubmed	NPC2 is expressed in human and murine liver and secreted into bile: potential implications for body cholesterol homeostasis.	NPC1 NPC2	3.33e-06	2	64	2	16374838
Pubmed	Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport.	NPC1 NPC2	3.33e-06	2	64	2	15071184
Pubmed	Abnormal accumulation and recycling of glycoproteins visualized in Niemann-Pick type C cells using the chemical reporter strategy.	NPC1 NPC2	3.33e-06	2	64	2	23733943
Pubmed	Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease.	CFH CFHR3	3.33e-06	2	64	2	20694013
Pubmed	NPC1 late endosomes contain elevated levels of non-esterified ('free') fatty acids and an abnormally glycosylated form of the NPC2 protein.	NPC1 NPC2	3.33e-06	2	64	2	15896196
Pubmed	Secretion of sterols and the NPC2 protein from primary astrocytes.	NPC1 NPC2	3.33e-06	2	64	2	15355983
Pubmed	New variant associated with Niemann-Pick disease type C: Neurological manifestations and biochemical, molecular, and cellular characterisation.	NPC1 NPC2	3.33e-06	2	64	2	28865947
Pubmed	Identification and Classification of Rare Variants in NPC1 and NPC2 in Quebec.	NPC1 NPC2	3.33e-06	2	64	2	33990640
Pubmed	Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma.	NOTCH3 NOTCH4	3.33e-06	2	64	2	17696940
Pubmed	Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2.	NPC1 NPC2	3.33e-06	2	64	2	27551080
Pubmed	NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols.	NPC1 NPC2	3.33e-06	2	64	2	12719428
Pubmed	High incidence of unrecognized visceral/neurological late-onset Niemann-Pick disease, type C1, predicted by analysis of massively parallel sequencing data sets.	NPC1 NPC2	3.33e-06	2	64	2	25764212
Pubmed	Niemann-Pick Type C 1 (NPC1) and NPC2 Gene Variability in Demented Patients with Evidence of Brain Amyloid Deposition.	NPC1 NPC2	3.33e-06	2	64	2	34420959
Pubmed	Niemann-Pick C1 functions independently of Niemann-Pick C2 in the initial stage of retrograde transport of membrane-impermeable lysosomal cargo.	NPC1 NPC2	3.33e-06	2	64	2	20007703
Pubmed	Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells.	CFH CFHR3	3.33e-06	2	64	2	34819935
Pubmed	Pulmonary abnormalities in animal models due to Niemann-Pick type C1 (NPC1) or C2 (NPC2) disease.	NPC1 NPC2	3.33e-06	2	64	2	23843985
Pubmed	NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes.	NPC1 NPC2	3.33e-06	2	64	2	18772377
Pubmed	Role of Niemann-Pick Type C Disease Mutations in Dementia.	NPC1 NPC2	3.33e-06	2	64	2	27792009
Pubmed	Niemann-Pick Disease Type C	NPC1 NPC2	3.33e-06	2	64	2	20301473
Pubmed	Novel Roles for Notch3 and Notch4 Receptors in Gene Expression and Susceptibility to Ozone-Induced Lung Inflammation in Mice.	NOTCH3 NOTCH4	3.33e-06	2	64	2	25658374
Pubmed	Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes.	NPC1 NPC2	3.33e-06	2	64	2	20674861
Pubmed	Do mammalian NPC1 and NPC2 play a role in intestinal cholesterol absorption?	NPC1 NPC2	3.33e-06	2	64	2	17880278
Pubmed	Association study between the TNXB locus and schizophrenia in a Japanese population.	TNXB NOTCH4	3.33e-06	2	64	2	17192952
Pubmed	Diagnostic tests for Niemann-Pick disease type C (NP-C): A critical review.	NPC1 NPC2	3.33e-06	2	64	2	27339554
Pubmed	Molecular analysis of NPC1 and NPC2 gene in 34 Niemann-Pick C Italian patients: identification and structural modeling of novel mutations.	NPC1 NPC2	3.33e-06	2	64	2	19252935
Pubmed	Simulations of NPC1(NTD):NPC2 Protein Complex Reveal Cholesterol Transfer Pathways.	NPC1 NPC2	3.33e-06	2	64	2	30181526
Pubmed	Altered vitamin E status in Niemann-Pick type C disease.	NPC1 NPC2	3.33e-06	2	64	2	21550990
Pubmed	Computational studies of the cholesterol transport between NPC2 and the N-terminal domain of NPC1 (NPC1(NTD)).	NPC1 NPC2	3.33e-06	2	64	2	24001314
Pubmed	A genetic determinant that specifically regulates the frequency of hematopoietic stem cells.	NOTCH3 NOTCH4	3.33e-06	2	64	2	11777956
Pubmed	Mutations in Niemann Pick type C gene are risk factor for Alzheimer's disease.	NPC1 NPC2	3.33e-06	2	64	2	25220527
Pubmed	A De Novo Deletion in the Regulators of Complement Activation Cluster Producing a Hybrid Complement Factor H/Complement Factor H-Related 3 Gene in Atypical Hemolytic Uremic Syndrome.	CFH CFHR3	3.33e-06	2	64	2	26490391
Pubmed	Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection.	NPC1 NPC2	3.33e-06	2	64	2	27238017
Pubmed	Diagnosis of Niemann-Pick disease type C with 7-ketocholesterol screening followed by NPC1/NPC2 gene mutation confirmation in Chinese patients.	NPC1 NPC2	3.33e-06	2	64	2	24915861
Pubmed	Niemann-Pick type C disease: a QM/MM study of conformational changes in cholesterol in the NPC1(NTD) and NPC2 binding pockets.	NPC1 NPC2	3.33e-06	2	64	2	25251378
Pubmed	Ontogenic changes in lung cholesterol metabolism, lipid content, and histology in mice with Niemann-Pick type C disease.	NPC1 NPC2	3.33e-06	2	64	2	24076310
Pubmed	AAV9-NPC1 significantly ameliorates Purkinje cell death and behavioral abnormalities in mouse NPC disease.	NPC1 NPC2	3.33e-06	2	64	2	28053186
Pubmed	Niemann-Pick Type C2 protein contributes to the transport of endosomal cholesterol to mitochondria without interacting with NPC1.	NPC1 NPC2	3.33e-06	2	64	2	22962690
Pubmed	Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.	COL13A1 COL21A1 EGFL7 AGRN TNXB	5.19e-06	135	64	5	28675934
Pubmed	Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.	ADAMTS20 SSPOP AGRN TNXB	6.10e-06	64	64	4	22261194
Pubmed	Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception.	EGFL7 NOTCH3 NOTCH4	7.72e-06	21	64	3	28656980
Pubmed	Associations of CFHR1-CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent.	CFH CFHR3	9.99e-06	3	64	2	20581873
Pubmed	Complement factor H, FHR-3 and FHR-1 variants associate in an extended haplotype conferring increased risk of atypical hemolytic uremic syndrome.	CFH CFHR3	9.99e-06	3	64	2	26163426
Pubmed	Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes.	CFH CFHR3	9.99e-06	3	64	2	10781834
Pubmed	Association assessment of copy number polymorphism and risk of age-related macular degeneration.	CFH CFHR3	9.99e-06	3	64	2	21856016
Pubmed	Notch receptor expression in human brain arteriovenous malformations.	NOTCH3 NOTCH4	9.99e-06	3	64	2	25846406
Pubmed	A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32.	CFH CR2	9.99e-06	3	64	2	3782802
Pubmed	Variants in Complement Factor H and Complement Factor H-Related Protein Genes, CFHR3 and CFHR1, Affect Complement Activation in IgA Nephropathy.	CFH CFHR3	9.99e-06	3	64	2	25205734
Pubmed	Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency.	CFH CFHR3	9.99e-06	3	64	2	18006700
Pubmed	Lgr6+ stem cells and their progeny in mouse epidermis under regimens of exogenous skin carcinogenesis, and their absence in ensuing skin tumors.	LGR6 HR	9.99e-06	3	64	2	27880932
Pubmed	Atypical hemolytic uremic syndrome associated with complement factor H autoantibodies and CFHR1/CFHR3 deficiency.	CFH CFHR3	9.99e-06	3	64	2	19531976
Pubmed	Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations.	NPC1 NPC2	9.99e-06	3	64	2	21289032
Pubmed	Sterols and intracellular vesicular trafficking: lessons from the study of NPC1.	NPC1 NPC2	9.99e-06	3	64	2	12398991
Pubmed	Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice.	CFH CR2	9.99e-06	3	64	2	19828624
Pubmed	FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.	NPC1 NPC2	9.99e-06	3	64	2	28082351
Pubmed	ABCA1-dependent mobilization of lysosomal cholesterol requires functional Niemann-Pick C2 but not Niemann-Pick C1 protein.	NPC1 NPC2	9.99e-06	3	64	2	22179027
Pubmed	Evaluation of CFH Y402H polymorphism and CFHR3/CFHR1 deletion in age-related macular degeneration patients from Brazil.	CFH CFHR3	9.99e-06	3	64	2	26942649
Pubmed	An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD).	CFH CFHR3	9.99e-06	3	64	2	20843825
Pubmed	Associations of CFH polymorphisms and CFHR1-CFHR3 deletion with blood pressure and hypertension in Chinese population.	CFH CFHR3	9.99e-06	3	64	2	22848687
Pubmed	Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype.	NOTCH3 NOTCH4	9.99e-06	3	64	2	15645445
Pubmed	A genome-wide association study identifies key modulators of complement factor H binding to malondialdehyde-epitopes.	CFH CFHR3	9.99e-06	3	64	2	32321835
Pubmed	Two factor H-related proteins from the mouse: expression analysis and functional characterization.	CFH CFHR3	9.99e-06	3	64	2	17028856
Pubmed	Localization of complement factor H gene expression and protein distribution in the mouse outer retina.	CFH CFHR3	9.99e-06	3	64	2	25684976
Pubmed	Genetic contributions of nonautoimmune SWR mice toward lupus nephritis.	CFH CR2 NOTCH4	1.17e-05	24	64	3	11739537
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	COL23A1 COL13A1 EGFL7 COLQ AGRN	1.46e-05	167	64	5	22159717
Pubmed	Congenital Myasthenic Syndromes Overview	COL13A1 COLQ AGRN	1.50e-05	26	64	3	20301347
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	COL22A1 EGFL7 SSPOP AGRN TNXB	1.83e-05	175	64	5	28071719
Pubmed	Atypical haemolytic-uraemic syndrome due to heterozygous mutations of CFH/CFHR1-3 and complement factor H 479.	CFH CFHR3	2.00e-05	4	64	2	24333077
Pubmed	Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer.	NOTCH3 NOTCH4	2.00e-05	4	64	2	28061457
Pubmed	The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors.	NOTCH3 NOTCH4	2.00e-05	4	64	2	24145721
Pubmed	A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma.	NOTCH3 NOTCH4	2.00e-05	4	64	2	20069356
Pubmed	Expression and clinical significance of Notch receptors in human renal cell carcinoma.	NOTCH3 NOTCH4	2.00e-05	4	64	2	19404845
Pubmed	Notch signaling pathway regulates the growth and the expression of inflammatory cytokines in mouse basophils.	NOTCH3 NOTCH4	2.00e-05	4	64	2	28669409
Pubmed	Evolutionary analysis of vertebrate Notch genes.	NOTCH3 NOTCH4	2.00e-05	4	64	2	11466531
Pubmed	Abnormal expression pattern of Notch receptors, ligands, and downstream effectors in the dorsolateral prefrontal cortex and amygdala of suicidal victims.	NOTCH3 NOTCH4	2.00e-05	4	64	2	24151014
Pubmed	Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): evolutionary conservation of multiple expression domains in amphioxus and vertebrates.	NOTCH3 NOTCH4	2.00e-05	4	64	2	11401408
Pubmed	The collagen ColQ binds to LRP4 and regulates the activation of the Muscle-Specific Kinase-LRP4 receptor complex by agrin at the neuromuscular junction.	COLQ AGRN	2.00e-05	4	64	2	37356721
Pubmed	Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation.	NOTCH3 NOTCH4	2.00e-05	4	64	2	10194420
Pubmed	Functional conservation of mouse Notch receptor family members.	NOTCH3 NOTCH4	2.00e-05	4	64	2	8898100
Pubmed	Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.	NOTCH3 NOTCH4	2.00e-05	4	64	2	11459941
Pubmed	MicroRNA-183 suppresses cancer stem-like cell properties in EBV-associated nasopharyngeal carcinoma.	NOTCH3 NOTCH4	2.00e-05	4	64	2	27431799
Pubmed	CFH and CFHR structural variants in atypical Hemolytic Uremic Syndrome: Prevalence, genomic characterization and impact on outcome.	CFH CFHR3	2.00e-05	4	64	2	36793547
Pubmed	Aberrant Regulation of Notch3 Signaling Pathway in Polycystic Kidney Disease.	PKD1 NOTCH3	2.00e-05	4	64	2	29463793
Pubmed	Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages.	NPC1 NPC2	2.00e-05	4	64	2	16141411
Pubmed	Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias.	NOTCH3 NOTCH4	2.00e-05	4	64	2	18184405
Pubmed	Notch signaling in the mammalian central nervous system: insights from mouse mutants.	NOTCH3 NOTCH4	2.00e-05	4	64	2	15917835
Cytoband	1q32	CFH CR2 CFHR3	4.55e-05	49	64	3	1q32
Cytoband	17q25.3	TMC8 GALR2 BAHCC1	3.91e-04	101	64	3	17q25.3
GeneFamily	Collagens	COL23A1 COL13A1 COL21A1 COL22A1	3.82e-06	46	42	4	490
GeneFamily	Complement system\|Sushi domain containing	CFH CR2 CFHR3	7.89e-05	36	42	3	492
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CFH CR2 CFHR3	3.13e-04	57	42	3	1179
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	PXDNL OBSCN LINGO3 IGFBPL1	5.21e-04	161	42	4	593
Coexpression	NABA_CORE_MATRISOME	COL23A1 COL13A1 COL21A1 PXDNL KCP COL22A1 COLQ SSPOP AGRN TNXB IGFBPL1	6.31e-11	275	64	11	M5884
Coexpression	NABA_MATRISOME	COL23A1 COL13A1 COL21A1 PXDNL ADAM15 KCP ADAMTS20 MUC5B COL22A1 EGFL7 COLQ SSPOP AGRN TNXB IGFBPL1	1.85e-08	1026	64	15	M5889
Coexpression	NABA_CORE_MATRISOME	COL23A1 COL13A1 KCP COL22A1 COLQ SSPOP AGRN TNXB IGFBPL1	1.92e-08	270	64	9	MM17057
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K27ME3	OLIG3 DRD4 COL13A1 KCP LGR6 TNXB IGFBPL1 NOTCH3	3.25e-07	272	64	8	M1938
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K27ME3	OLIG3 DRD4 COL13A1 KCP LGR6 TNXB IGFBPL1 NOTCH3	4.27e-07	282	64	8	MM822
Coexpression	NABA_ECM_GLYCOPROTEINS	PXDNL KCP COLQ SSPOP AGRN TNXB IGFBPL1	5.09e-07	196	64	7	M3008
Coexpression	NABA_MATRISOME	COL23A1 COL13A1 ADAM15 KCP ADAMTS20 MUC5B COL22A1 EGFL7 COLQ SSPOP AGRN TNXB IGFBPL1	7.92e-07	1008	64	13	MM17056
Coexpression	NABA_COLLAGENS	COL23A1 COL13A1 COL21A1 COL22A1	4.08e-06	44	64	4	M3005
Coexpression	NABA_ECM_GLYCOPROTEINS	KCP COLQ SSPOP AGRN TNXB IGFBPL1	7.30e-06	191	64	6	MM17059
Coexpression	GSE15930_NAIVE_VS_24H_IN_VITRO_STIM_IL12_CD8_TCELL_UP	CFH TRAFD1 PKD1 COLQ AGRN HR	9.50e-06	200	64	6	M3589
Coexpression	HEBERT_MATRISOME_TNBC_BRAIN_METASTASIS	COL23A1 EGFL7 AGRN	3.47e-05	26	64	3	M47999
Coexpression	HATADA_METHYLATED_IN_LUNG_CANCER_DN	IGFLR1 BAHCC1 CFAP65	9.36e-05	36	64	3	M11680
Coexpression	BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS	CFH SEC16A CD320 COLQ IGFBPL1 HOXB13 NOTCH4 PGR HR	1.18e-04	786	64	9	M2388
Coexpression	GSE15930_NAIVE_VS_24H_IN_VITRO_STIM_CD8_TCELL_UP	TRAFD1 PKD1 COLQ AGRN HR	1.30e-04	200	64	5	M3587
Coexpression	GSE42021_TREG_VS_TCONV_PLN_UP	CFH VPS9D1 TRAFD1 IGFLR1 CCKAR	1.30e-04	200	64	5	M9572
Coexpression	ZENG_GU_ICB_CONTROL_METAGENE_31_PRECICTIVE_ICB_RESISTANCE	RHPN1 DRD4 ADAMTS20 LGR6 HUNK	1.33e-04	201	64	5	MM17086
Coexpression	PEREZ_TP53_TARGETS	KRBA1 COL13A1 IRX5 COL21A1 OBSCN KCP FAM83D COL22A1 HUNK GALR2 HR	1.42e-04	1201	64	11	M4391
Coexpression	PEREZ_TP53_AND_TP63_TARGETS	IRX5 HUNK GALR2 NOTCH3 HR	1.53e-04	207	64	5	M14566
Coexpression	NABA_COLLAGENS	COL23A1 COL13A1 COL22A1	1.60e-04	43	64	3	MM17060
Coexpression	BLANCO_MELO_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_A594_CELLS_DN	FCGBP MUC5B HOXB13 HR	2.08e-04	119	64	4	M34009
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HNPROG	EFS FMN2 FAM83D HUNK IGFBPL1	2.44e-04	229	64	5	M39062
Coexpression	FAN_EMBRYONIC_CTX_BIG_GROUPS_BRAIN_ENDOTHELIAL	AFAP1L2 EGFL7 CD320 AGRN NOTCH3 NOTCH4	2.66e-04	365	64	6	M39018
CoexpressionAtlas	DevelopingKidney_e11.5_metaneph mesench_emap-3843_k-means-cluster#5_top-relative-expression-ranked_1000	COL23A1 C11orf87 COL22A1 EGFL7 NOTCH4	2.42e-05	114	64	5	gudmap_developingKidney_e11.5_metaneph mesench_1000_k5
CoexpressionAtlas	DevelopingKidney_e11.5_metaneph mesench_emap-3843_top-relative-expression-ranked_1000	COL23A1 KCP C11orf87 NPC2 COL22A1 EGFL7 HUNK CD320 NOTCH4 BAHCC1 DDX11	4.23e-05	850	64	11	gudmap_developingKidney_e11.5_metaneph mesench_1000
ToppCell	Club-club-8\|World / Class top	CFH FCGBP MUC5B LGR6 TNXB CCKAR	2.49e-07	182	64	6	8111d917e588008d947021460ddf8f1e7ae1337a
ToppCell	droplet-Kidney-nan-3m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AFAP1L2 C11orf87 NOTCH3 NOTCH4 PGR HR	3.01e-07	188	64	6	ec0e241de2c8310b4417b9d4e2420d7a1662f1c0
ToppCell	droplet-Kidney-nan-21m-Endothelial-kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AFAP1L2 ADAM15 OBSCN EGFL7 NOTCH4 PGR	3.11e-07	189	64	6	2ce330d8078833c05775c481e73770f9ee4a5c88
ToppCell	droplet-Kidney-nan-21m-Endothelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AFAP1L2 ADAM15 OBSCN EGFL7 NOTCH4 PGR	3.11e-07	189	64	6	473c87036e04a058b4a5138438b7ba7e1e766799
ToppCell	Mesenchymal_cells-Ng2+_MSCs\|World / Lineage and Cell class	CFH COL13A1 IRX5 C11orf87 COL22A1 GALR2	3.41e-07	192	64	6	0703b8ec6960ff975ee5a2737054db67cab016b5
ToppCell	cellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	AFAP1L2 COL21A1 ADAM15 EGFL7 CD320 NOTCH4	3.73e-07	195	64	6	75db19c0371320ea5fce1d6de8c1b40b1e6a2e58
ToppCell	Club_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	FCGBP TMEM132A MUC5B NOTCH3 DDX11	3.54e-06	161	64	5	bd08a23b415617f6e8748ed2668d578a860ecf91
ToppCell	normal_Pleural_Fluid-Myeloid_cells-mo-Mac\|Myeloid_cells / Location, Cell class and cell subclass	ZIC5 FAM83D ANKRD24 COL22A1 EGFL7	4.12e-06	166	64	5	d16af6570806ed2880bd0efb5298932fd2a89cf5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL23A1 COL13A1 COL21A1 LGR6 NOTCH3	4.62e-06	170	64	5	99dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL23A1 COL13A1 COL21A1 LGR6 NOTCH3	4.62e-06	170	64	5	3a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL23A1 COL13A1 COL21A1 LGR6 NOTCH3	4.62e-06	170	64	5	cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCell	droplet-Pancreas-Exocrine-21m-Epithelial-pancreatic_ductal_cel\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP IRX5 IGFBPL1 PGR HR	4.89e-06	172	64	5	c0bda7153e02bee7d0326138cc684151c404c2a1
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	ADAM15 EGFL7 AGRN NOTCH4 CFAP65	5.18e-06	174	64	5	b4f3f5334803e5903bc496decf923f2e44f7fa3c
ToppCell	droplet-Pancreas-Exocrine-21m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP IRX5 KCP IGFBPL1 PGR	5.18e-06	174	64	5	a0ccda8fd6f55251cdeff24cf66e72e4a31d2104
ToppCell	Adult-Epithelial-lung_goblet_cell-D231\|Adult / Lineage, Cell type, age group and donor	FCGBP FAM83D MUC5B HUNK NOTCH3	5.18e-06	174	64	5	7d2f802f493f19a068e097b2909a9000e2160266
ToppCell	COVID-19-kidney-REN+Pericyte\|kidney / Disease (COVID-19 only), tissue and cell type	COL23A1 COL13A1 AFAP1L2 NOTCH3 PGR	5.94e-06	179	64	5	342c1cc4444f51b8dcb30d3adc98285a25669c6e
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL23A1 COL13A1 COL21A1 PXDNL TNXB	6.11e-06	180	64	5	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL23A1 COL13A1 COL21A1 PXDNL TNXB	6.11e-06	180	64	5	9b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN ADAMTS20 MUC5B COL22A1 SSPOP	6.79e-06	184	64	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN ADAMTS20 MUC5B COL22A1 SSPOP	6.79e-06	184	64	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN ADAMTS20 MUC5B COL22A1 SSPOP	6.79e-06	184	64	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	wk_20-22-Endothelial-Lymph_endothelial-SCG3+_lymphatic_endothelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	C11orf87 EGFL7 AGRN TNXB HR	7.35e-06	187	64	5	55aad84b992412e487a32f4970620189a7380ba6
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH ADAM15 EGFL7 TNXB NOTCH4	7.54e-06	188	64	5	a37edd8f9e4a4e336b5acbb0407d3d275975cee8
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAM15 EGFL7 CD320 AGRN NOTCH4	7.54e-06	188	64	5	0026c9479b30fb39daa91cfa220a88f9c9e65fe7
ToppCell	Mesenchymal_cells-Osteoblasts\|World / Lineage and Cell class	CFH DRD4 COL13A1 IRX5 COL22A1	7.54e-06	188	64	5	89f7f5a51be7e046a63e2413f86c521ae4b6718f
ToppCell	wk_15-18-Endothelial-Lymph_endothelial-SCG3+_lymphatic_endothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ZIC5 C11orf87 EGFL7 AGRN TNXB	7.74e-06	189	64	5	f0418851ad4042c4cd87c8729e4f0d43bdf8fccb
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL23A1 CFH COL13A1 COLQ TNXB	8.14e-06	191	64	5	a261f0738d974784bbdd60f23092bfbcca464459
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL23A1 CFH COL13A1 COLQ TNXB	8.14e-06	191	64	5	6594398cc8151c73696391a43ac110c10283dab1
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AFAP1L2 ADAM15 EGFL7 CD320 NOTCH4	8.14e-06	191	64	5	04c7aa2e39fdd08ca24c10d43b29a5e41a73b9e0
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL23A1 CFH COL13A1 COLQ TNXB	8.14e-06	191	64	5	d04e6292fef189b8d8ed0f4b0c310b2b250fd30e
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AFAP1L2 ADAM15 EGFL7 CD320 NOTCH4	8.14e-06	191	64	5	db8dd6bbba803585bdd6a55d5c403d383f2e9acf
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL23A1 CFH COL13A1 COLQ TNXB	8.14e-06	191	64	5	de3e9b704621b26836c2ddc39fa3e840dfb4541b
ToppCell	droplet-Lung-1m-Endothelial-venous_endothelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AFAP1L2 ADAM15 OBSCN EGFL7 IGFBPL1	8.35e-06	192	64	5	1990dc8a81594018a5bf596be99d0b5f0af0f58f
ToppCell	Enterocyte_Progenitors-C_06\|Enterocyte_Progenitors / shred on cell type and cluster	CFH RHPN1 FCGBP MUC5B AGRN	8.35e-06	192	64	5	b9938e1a929c00628cc6ebfdf10cf285167f445c
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-G_(Club-Clara_cells)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	CFH FCGBP TMEM132A MUC5B NOTCH3	8.35e-06	192	64	5	c7c232545fad8ad327ab94bd0def8dc5daacd03d
ToppCell	droplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AFAP1L2 ADAM15 OBSCN EGFL7 IGFBPL1	8.35e-06	192	64	5	845cc9c18b4436b07dd3ce7980052683937546d2
ToppCell	droplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AFAP1L2 ADAM15 OBSCN EGFL7 IGFBPL1	8.35e-06	192	64	5	c72a082c93a8825adbfef37f889ba3a7052f201b
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL13A1 AFAP1L2 ADAMTS20 COL22A1 GALR2	8.56e-06	193	64	5	f27e2be497745098b5269aa799dd3d5f62d78ba7
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AFAP1L2 ADAM15 EGFL7 CD320 NOTCH4	8.56e-06	193	64	5	3a9fe4e709c09ec787c71bdd6b58a71c419896de
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related-ICC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL13A1 AFAP1L2 ADAMTS20 COL22A1 GALR2	8.56e-06	193	64	5	4ccf984baebbb13ae916727137ce593fda7514a2
ToppCell	Epithelial_cells-Club_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	CFH FCGBP MUC5B NOTCH3 DDX11	9.00e-06	195	64	5	b758676abfc4e6930b696d270ecc0ea461b87a54
ToppCell	wk_20-22-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ADAM15 EGFL7 CD320 AGRN NOTCH4	9.00e-06	195	64	5	a432d69b0172211ee4d53675936a1dc9ce1ae1f0
ToppCell	COVID-19-kidney-VWF+PLVAP+VCAM1+EC\|kidney / Disease (COVID-19 only), tissue and cell type	COL13A1 ADAM15 EGFL7 TNXB NOTCH4	9.23e-06	196	64	5	ac2c4a325efa8497a755cd31fb6a9d94d8e3bf42
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH ADAM15 EGFL7 TNXB NOTCH4	9.23e-06	196	64	5	a20a56d8997d6db2a10046c8801c619a379de83c
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL13A1 ADAM15 EGFL7 TNXB NOTCH4	9.23e-06	196	64	5	95c5b8fd4ebfae1f42de9b1475c1161d4a80e515
ToppCell	10x5'v1-week_17-19-Mesenchymal_osteo-stroma-osteoblast_precursor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CFH COL21A1 PXDNL HUNK PGR	9.23e-06	196	64	5	57df2a57b35be9851ac0b1e5731baa53052511f0
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_immune_recruiting\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	COL13A1 EFS ARSG NOTCH3 PGR	9.23e-06	196	64	5	614a07334707eafe238d5cb7b080a3ca796a1920
ToppCell	Tracheal-10x3prime_v2-Stromal-Mesofibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	COL23A1 CFH EFS TNXB PGR	9.46e-06	197	64	5	d7cef7881abd807a679432766ced609a6efd1067
ToppCell	Tracheal-10x3prime_v2-Stromal-Mesofibroblastic-Mesothelia\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	COL23A1 CFH EFS TNXB PGR	9.46e-06	197	64	5	20a5958512bdb99daeb8f4d244df53e4f048f879
ToppCell	distal-mesenchymal-Myofibroblast-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH EFS ZIC5 LGR6 CFHR3	9.69e-06	198	64	5	beef5075ba6dcd4d0a447bc4e57efcaf2e93c546
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular-3\|TCGA-Stomach / Sample_Type by Project: Shred V9	NPC1 KRT72 COL13A1 NOTCH4	9.88e-06	93	64	4	d108fce6bc55e76ba1861ab601bffca29b85b8fa
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CFH AFAP1L2 COL21A1 FMN2 TNXB	9.93e-06	199	64	5	3835452e4848d7f7dd8651c17b746b271ef39688
ToppCell	Biopsy_Control_(H.)-Epithelial-MUC5B+\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	CFH FCGBP FAM83D MUC5B NOTCH3	9.93e-06	199	64	5	4ab45996e6bca406c77895a5998982b8ab1cf210
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CFH EGFL7 CD320 NOTCH4 PGR	9.93e-06	199	64	5	236b1417ed0875e98c6ec1ec714003bfce438d65
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CFH AFAP1L2 EGFL7 NOTCH4 CFHR3	9.93e-06	199	64	5	6a2943a23fdd2ec814662db7c21a0d6804a6cbbc
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CFH AFAP1L2 EGFL7 AGRN NOTCH4	9.93e-06	199	64	5	1295f34a350bf48987e2fad411aaac3630efd3f1
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH ADAM15 EGFL7 TNXB NOTCH4	9.93e-06	199	64	5	33f1669eeb701986b4dec409efdb6c06c3c41c2b
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CFH FCGBP MUC5B HUNK NOTCH3	1.02e-05	200	64	5	b992eeddee38e6fe3564e9b1850f6b20b89bf47d
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH ADAM15 EGFL7 TNXB NOTCH4	1.02e-05	200	64	5	93e13937ec74418a697c37d56f57509fb2154780
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAM15 EGFL7 CD320 AGRN NOTCH4	1.02e-05	200	64	5	90061284a80d29a4ca6078f578e13d32b8cc80e1
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Dcn-Endothelial_Tip.Dcn.Nenf_(Nenf)\|Thalamus / BrainAtlas - Mouse McCarroll V32	COL23A1 COL13A1 COL22A1 TNXB	2.21e-05	114	64	4	7be16e7f7b9c9dbd68933ace3b7f8f661bed41a7
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Dcn\|Thalamus / BrainAtlas - Mouse McCarroll V32	COL23A1 COL13A1 COL22A1 TNXB	2.21e-05	114	64	4	f4bdfc47418d22a49e0c4a6c3bd0663e15fb53bb
ToppCell	Epithelial-Epithelial-D_(Clara-Club_cells)\|Epithelial / shred on cell class and cell subclass (v4)	COL23A1 MUC5B COL22A1 CCKAR	2.98e-05	123	64	4	caa1576f1b5eb592d522be61c090ac444e277ac5
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL13A1 COL21A1 PXDNL TNXB	3.17e-05	125	64	4	b162a5bfbb8ac5e65e13578fef9de442a9e4fd8b
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Monophasic_Synovial_Sarcoma\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	COL23A1 DRD4 ZIC5 LGR6	4.54e-05	137	64	4	576ca865b8e8e59d23aa35cb9dafee0cf7d38e6a
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL23A1 LGR6 NOTCH3 PGR	5.81e-05	146	64	4	2ac9b487a7991fdc15444aeb93533030e09825bb
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL23A1 COL13A1 COL21A1 HR	6.45e-05	150	64	4	8645b9c7f9511ed6cc9afe04440c2873a3094150
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AFAP1L2 KCP MUC5B HUNK	6.62e-05	151	64	4	10da94037225a71844281ddcb395072250a78094
ToppCell	P15-Epithelial-epithelial_progenitor_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 ADAMTS20 NPC2 MUC5B	6.80e-05	152	64	4	00d5503d462cfa009fb4cac79ecee11725a18b9a
ToppCell	Club-club-11\|World / Class top	FCGBP MUC5B CCKAR	6.83e-05	55	64	3	d1d832e1c98a89e2b461127922c3e4d7f42d7401
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Thalamus / BrainAtlas - Mouse McCarroll V32	COL23A1 COL13A1 COL22A1 TNXB	6.97e-05	153	64	4	e9c6fb5c41adb6595c66c3a917fe455348279e54
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1\|Thalamus / BrainAtlas - Mouse McCarroll V32	COL23A1 COL13A1 COL22A1 TNXB	6.97e-05	153	64	4	b8b5ff7d2feea3e3a352fb5530e49f639fe1ff88
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP\|Thalamus / BrainAtlas - Mouse McCarroll V32	COL23A1 COL13A1 COL22A1 TNXB	6.97e-05	153	64	4	2513edfae62a44e51d3556675a096723194c966c
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AFAP1L2 KCP NOTCH3 PGR	7.51e-05	156	64	4	6365b69ede98bc866e996bc52736b00401aacf6f
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AFAP1L2 KCP NOTCH3 PGR	7.70e-05	157	64	4	bfec34182f052cf1c0d847ba53ea335d4d1190de
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	AFAP1L2 TMEM132A EGFL7 NOTCH4	7.70e-05	157	64	4	275a4c6fef1fff8da2bdc48e3924ad05c5e5cfc8
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D122\|Adult / Lineage, Cell type, age group and donor	AFAP1L2 ADAM15 EGFL7 NOTCH4	8.29e-05	160	64	4	0cfe130606af433b2aa90e0a20b6c44659dd6fd4
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL23A1 COL13A1 AFAP1L2 NOTCH3	8.49e-05	161	64	4	1b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCell	TCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-3\|TCGA-Adrenal / Sample_Type by Project: Shred V9	AFAP1L2 EGFL7 NOTCH3 NOTCH4	8.49e-05	161	64	4	52239a887799362256ecd7e740b716b88ed59a62
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 EGFL7 TNXB NOTCH4	8.70e-05	162	64	4	c399b9e4854916a59f5cae2d8dbf19660f8759be
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 EGFL7 TNXB NOTCH4	8.70e-05	162	64	4	a291248b693c771845174393934a782f1d8bd7ce
ToppCell	facs-Trachea-18m-Epithelial-glandular_epithelial-lung_secretory_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RHPN1 CDSN AFAP1L2 DDX11	9.12e-05	164	64	4	cdb8cd2d6b369189ea77e4946738e2816d502e03
ToppCell	facs-Trachea-18m-Epithelial-glandular_epithelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RHPN1 CDSN AFAP1L2 DDX11	9.12e-05	164	64	4	5dbfcdd450f652b16d97da53b528d4584b0eabcf
ToppCell	facs-Trachea-18m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RHPN1 CDSN AFAP1L2 DDX11	9.12e-05	164	64	4	f1423f4434af4af9c60c8a5b0b0abec4a7df9401
ToppCell	droplet-Fat-Scat-21m\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AFAP1L2 FCGBP EGFL7 PGR	9.34e-05	165	64	4	3f0c2486ea357d10dad0b703cf75cc29bdd5b5cf
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EECs\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RHPN1 IRX5 HOXB13 CFAP65	9.34e-05	165	64	4	4b4e75ad0eb0a6b00c30a000ec6267e23ba2e496
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL13A1 COL21A1 LGR6 NOTCH3	9.34e-05	165	64	4	9de841c1c95967c562720feba930246debc626fd
ToppCell	PND14-Epithelial-Epithelial_Airway-Neurosecretory\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL23A1 FCGBP MUC5B CCKAR	9.34e-05	165	64	4	6fdce8b23736409a23884ef3918638ffc067a86f
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL13A1 COL21A1 LGR6 NOTCH3	9.34e-05	165	64	4	a612a7d3a5415ecacc3df8fbff0ce498f982aad0
ToppCell	PND14-Epithelial-Epithelial_Airway-Neurosecretory-Secretory\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL23A1 FCGBP MUC5B CCKAR	9.34e-05	165	64	4	dd4d36ff8efb89fee1fb4c48d1b8f46902119909
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL13A1 COL21A1 LGR6 NOTCH3	9.34e-05	165	64	4	cdc94a640ec01c6892521bcd6f0ee0a66ff23866
ToppCell	PND14-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL23A1 FCGBP MUC5B CCKAR	9.34e-05	165	64	4	baff639a7046fb5cacb70f341b6d24cef3519f8e
ToppCell	Club_cells-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	CFH MUC5B NOTCH3 DDX11	9.56e-05	166	64	4	a440aa338aa0c6cd0b5800dfa7e83f8ca16fce1a
ToppCell	Club_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	CFH FCGBP MUC5B NOTCH3	9.78e-05	167	64	4	dbdaaeb3bd9139cb008d9fe24ec031fc5628f136
ToppCell	Adult-Mesenchymal-myofibroblast_cell\|Adult / Lineage, Cell type, age group and donor	CFH COL13A1 AFAP1L2 TNXB	9.78e-05	167	64	4	d584a8548a5317bd9686b3be8246ae6ed568796b
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RHPN1 COL21A1 MUC5B CFAP65	1.00e-04	168	64	4	9a8709d34865cfa668d8f3335dc34fc86fc32482
ToppCell	droplet-Spleen-nan-21m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPC1 OBSCN NOTCH3 HR	1.02e-04	169	64	4	7962165cab84af73d20b56eb70b1ed87c94025ef
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZIC5 EGFL7 TNXB HR	1.05e-04	170	64	4	6035c92cd39c5ac54e7ec57d94888ee19f574639
ToppCell	droplet-Spleen-nan-21m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FCGBP ADAM15 PGR	1.05e-04	170	64	4	03cb4e508356f85372a588c8d1c6babf2a012683
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZIC5 EGFL7 TNXB HR	1.05e-04	170	64	4	c8c42eda44b61440c96b202e7f54650046eb95d3
Drug	L-3,4-dehydroproline	COL23A1 COL13A1 COL21A1 COL22A1 IGFLR1	1.94e-06	73	64	5	CID000094284
Drug	GK-101	COL23A1 COL13A1 COL21A1 COL22A1	3.13e-06	36	64	4	CID000161853
Drug	candesartan cilexetil	COL23A1 CDSN COL13A1 COL21A1 MYO18A COL22A1	3.33e-06	145	64	6	CID000002540
Drug	(2S)-N-[4-(aminomethyl)-1,1-dioxothian-4-yl]-2-[1-(benzenesulfonamido)ethylideneamino]-3-(1-methylcyclopentyl)propanamide	CFH CFHR3	7.78e-06	2	64	2	CID011840931
Drug	Madecassol	COL23A1 COL13A1 COL21A1 COL22A1	8.48e-06	46	64	4	CID000108062
Drug	ticlopidine	COL23A1 CFH COL13A1 COL21A1 COL22A1	1.06e-05	103	64	5	CID000005472
Drug	d-indobufen	COL23A1 COL13A1 COL21A1 COL22A1	1.19e-05	50	64	4	CID000044562
Drug	ridogrel	COL23A1 COL13A1 COL21A1 COL22A1	1.39e-05	52	64	4	CID005362391
Drug	AC1L1C2F	COL23A1 COL13A1 EFS COL21A1 COL22A1	1.46e-05	110	64	5	CID000001711
Drug	NSC49633	COL23A1 COL13A1 COL21A1 COL22A1	1.50e-05	53	64	4	CID000023340
Drug	Sulfapyridine [144-83-2]; Up 200; 16uM; MCF7; HT_HG-U133A	COL13A1 EFS COL21A1 MUC5B PGR HR	1.87e-05	196	64	6	6101_UP
Drug	chondroitin sulfate	COL23A1 COL13A1 COL21A1 COL22A1 AGRN TNXB ARSG DDX11	2.00e-05	413	64	8	CID000024766
Drug	Selara	COL23A1 COL13A1 COL21A1 COL22A1 PGR	2.71e-05	125	64	5	CID000150310
Drug	AC1LAKND	COL23A1 COL13A1 COL21A1 COL22A1	2.80e-05	62	64	4	CID000470146
Drug	DMSe	COL23A1 COL13A1 COL21A1 COL22A1 TNXB	3.52e-05	132	64	5	CID000020796
Drug	BAPN	COL23A1 COL13A1 COL21A1 COL22A1	4.79e-05	71	64	4	CID000001647
Drug	malotilate	COL23A1 COL13A1 COL21A1 COL22A1	4.79e-05	71	64	4	CID000004006
Drug	AC1NMZ1B	COL23A1 COL13A1 COL21A1 COL22A1	5.94e-05	75	64	4	CID005034185
Drug	strontium ranelate	COL23A1 COL13A1 COL21A1 COL22A1	6.59e-05	77	64	4	CID006918182
Drug	1zz2	CFH CDSN HUNK AGRN	8.42e-05	82	64	4	CID005287728
Drug	LMWH	COL23A1 CFH CDSN COL13A1 COL21A1 COL22A1 AGRN TNXB CFHR3	9.40e-05	663	64	9	CID000000772
Drug	hyaluronan	COL23A1 COL13A1 COL21A1 COL22A1 TNXB KRT36	9.60e-05	263	64	6	CID000024759
Drug	halofuginone lactate	COL23A1 COL13A1 COL21A1 COL22A1	9.69e-05	85	64	4	CID000062891
Drug	4-hydroxyproline	COL23A1 COL13A1 COL21A1 COL22A1	1.26e-04	91	64	4	CID000000825
Disease	ubiquitin-conjugating enzyme E2 G2 measurement	CFH TNXB NOTCH4	1.10e-06	10	63	3	EFO_0022035
Disease	Niemann-Pick disease, type C	NPC1 NPC2	4.49e-06	2	63	2	cv:C0220756
Disease	nuclear pore membrane glycoprotein 210-like measurement	CFH TNXB	4.49e-06	2	63	2	EFO_0802821
Disease	endoplasmic reticulum resident protein 29 measurement	EGFL7 TNXB NOTCH4	5.09e-06	16	63	3	EFO_0020346
Disease	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase measurement	CFH CFHR3	1.34e-05	3	63	2	EFO_0801568
Disease	anaphase-promoting complex subunit 7 measurement	CFH CFHR3	1.34e-05	3	63	2	EFO_0801381
Disease	HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1	CFH CFHR3	1.34e-05	3	63	2	C2749604
Disease	Sphingomyelin/cholesterol lipidosis	NPC1 NPC2	1.34e-05	3	63	2	cv:C0028064
Disease	HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1	CFH CFHR3	1.34e-05	3	63	2	235400
Disease	Hemolytic uremic syndrome, atypical, susceptibility to, 1	CFH CFHR3	1.34e-05	3	63	2	cv:C2749604
Disease	Myasthenic Syndromes, Congenital	COL13A1 COLQ AGRN	1.82e-05	24	63	3	C0751882
Disease	myeloperoxidase measurement	CFH TNXB NOTCH4	2.33e-05	26	63	3	EFO_0005243
Disease	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial measurement	CFH CFHR3	2.68e-05	4	63	2	EFO_0803292
Disease	Meningococcal Infections	CFH CFHR3	2.68e-05	4	63	2	C0025303
Disease	Niemann-Pick disease (implicated_via_orthology)	NPC1 NPC2	2.68e-05	4	63	2	DOID:14504 (implicated_via_orthology)
Disease	IGF-like family receptor 1 measurement	CFH IGFLR1	6.69e-05	6	63	2	EFO_0801687
Disease	Oral ulcer	CDSN KCP TNXB NOTCH4	8.26e-05	107	63	4	HP_0000155
Disease	alopecia (is_implicated_in)	CDSN HR	9.36e-05	7	63	2	DOID:987 (is_implicated_in)
Disease	ductal carcinoma in situ (is_implicated_in)	HOXB13 NOTCH4	9.36e-05	7	63	2	DOID:0060074 (is_implicated_in)
Disease	obesity (implicated_via_orthology)	SEC16A ADAMTS20 CCKAR NOTCH3 NOTCH4	9.77e-05	215	63	5	DOID:9970 (implicated_via_orthology)
Disease	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 measurement	CFH CCDC71L	1.25e-04	8	63	2	EFO_0802739
Disease	central serous retinopathy	CFH NOTCH4	1.25e-04	8	63	2	EFO_0009784
Disease	gdnf family receptor alpha-1 measurement	CFH TNXB	1.25e-04	8	63	2	EFO_0020400
Disease	atypical hemolytic-uremic syndrome (is_implicated_in)	CFH CFHR3	1.25e-04	8	63	2	DOID:0080301 (is_implicated_in)
Disease	kidney disease	CFH NOTCH4	1.25e-04	8	63	2	EFO_0003086
Disease	Squamous cell carcinoma	AFAP1L2 LGR6 NOTCH3 NOTCH4	1.46e-04	124	63	4	C0007137
Disease	Atypical hemolytic-uremic syndrome	CFH CFHR3	1.60e-04	9	63	2	cv:C2931788
Disease	Hemolytic-uremic syndrome	CFH CFHR3	1.60e-04	9	63	2	cv:C0019061
Disease	interleukin-36 alpha measurement	EGFL7 TNXB	1.60e-04	9	63	2	EFO_0021851
Disease	non-receptor tyrosine-protein kinase TYK2 measurement	CFH EGFL7	2.00e-04	10	63	2	EFO_0008251
Disease	Atypical Hemolytic Uremic Syndrome	CFH CFHR3	2.00e-04	10	63	2	C2931788
Disease	tonsillectomy risk measurement	TRAFD1 PXDNL EGFL7 TNXB NOTCH4	2.37e-04	260	63	5	EFO_0007924
Disease	UDP-glucuronic acid decarboxylase 1 measurement	CFH CCDC71L	2.44e-04	11	63	2	EFO_0803221
Disease	systemic lupus erythematosus, COVID-19	ADAM15 KCP TNXB	2.63e-04	58	63	3	MONDO_0007915, MONDO_0100096
Disease	systemic lupus erythematosus	CFH DRD4 TRAFD1 ADAM15 KCP EGFL7 TNXB NOTCH4	2.90e-04	799	63	8	MONDO_0007915
Disease	intracranial aneurysm (is_implicated_in)	PKD1 COL22A1	2.92e-04	12	63	2	DOID:10941 (is_implicated_in)
Disease	Myasthenic Syndromes, Congenital, Slow Channel	COL13A1 AGRN	5.28e-04	16	63	2	C0751885
Disease	carotid atherosclerosis	CCDC71L FMN2	5.28e-04	16	63	2	EFO_0009783
Disease	Congenital Myasthenic Syndromes, Postsynaptic	COL13A1 AGRN	5.98e-04	17	63	2	C0751883
Disease	asparaginase hypersensitivity	COL22A1 LGR6 DDX11	6.06e-04	77	63	3	EFO_0004881
Disease	Age-related macular degeneration	CFH CFHR3	6.71e-04	18	63	2	cv:C0242383
Disease	pulse pressure measurement	NPC1 COL23A1 CFH CCDC71L CDSN COL21A1 PXDNL PKD1 SSPOP NOTCH3	6.90e-04	1392	63	10	EFO_0005763
Disease	X-11470 measurement	TNXB NOTCH4	7.49e-04	19	63	2	EFO_0021241
Disease	Congenital Myasthenic Syndromes, Presynaptic	COL13A1 AGRN	7.49e-04	19	63	2	C0751884
Disease	systemic scleroderma	KCP CR2 NOTCH4	8.09e-04	85	63	3	EFO_0000717
Disease	age-related macular degeneration	CFH TNXB NOTCH4	9.24e-04	89	63	3	EFO_0001365
Disease	Carcinoma, Pancreatic Ductal	NOTCH3 NOTCH4	1.20e-03	24	63	2	C0887833
Disease	complement C4b measurement	TNXB NOTCH4	1.30e-03	25	63	2	EFO_0008092
Disease	complement factor H-related protein 2 measurement	CFH DDX11	1.76e-03	29	63	2	EFO_0600055
Disease	Age related macular degeneration	CFH CFHR3	1.88e-03	30	63	2	C0242383

Protein segments in the cluster

Peptide	Gene	Start	Entry
PSPAAGPTKLPPCCH	BAHCC1	981	Q9P281
CVPKGGPPRVAPNPT	EGFL7	176	Q9UHF1
PGNSCPCPGPAPAKT	ADAM15	361	Q13444
GQCVCPRCEHPPPGP	AGRN	616	O00468
SGPGPTPDEPCIKCP	AFAP1L2	576	Q8N4X5
PPCPACPQGDGPSRN	ARSG	176	Q96EG1
SSPPQCEGLPCKSPP	CFH	921	P08603
QCKDSTGKCGPPPPI	CFH	1101	P08603
PCCPNPGPPGARGEV	CCKAR	386	P32238
GSCPPCGPCPIPKPA	ANKRD24	21	Q8TF21
PPCSNGGLPGKPCPP	CDSN	271	Q15517
SKPPELQQCGPGPCP	ADAMTS20	1346	P59510
PGLEGCYPKCPPSQP	MUC5B	1191	Q9HC84
GSPCPPCPGPIAGQA	IRX5	356	P78411
PIPEPDGCKSGINCP	NPC2	86	P61916
GGHKACCLLTPPPPP	COLQ	46	Q9Y215
CKPPVPLSPCPGGTP	KRBA1	676	A5PL33
PQPGPGPTACPAPCH	LGR6	26	Q9HBX8
PSVQCSPTPGPFKPC	LGR6	541	Q9HBX8
IEPCTQKGQCPPPPG	CD320	91	Q9NPF0
QKGQCPPPPGLPCPC	CD320	96	Q9NPF0
GACPGPEAPNPVPLC	CFAP65	661	Q6ZU64
EAPSECVCPPGPPGR	COL23A1	111	Q86Y22
CGPACPPRCGPLMPE	HR	111	O43593
VPAACLSPCGPPNPT	FAM83D	11	Q9H4H8
GPLCENPAVPCAPSP	NOTCH3	191	Q9UM47
PKCGPCRPEGCPAPA	IGFBPL1	36	Q8WX77
CRPEGCPAPAPCPAP	IGFBPL1	41	Q8WX77
PAAPPPAGGCPARCE	LINGO3	16	P0C6S8
RSAPGPAICPAPCPG	DDX11	856	Q96FC9
PPAPGLPPDPCGSNC	DRD4	296	P21917
GLPCPCTICQMPPPP	OLIG3	236	Q7RTU3
QDCSIVCGPKPQPPP	NPC1	241	O15118
CPPGSFPPGSCKEAP	OBSCN	7056	Q5VST9
QQGPFAPPPCKAPGA	PGR	471	P06401
CPPAPCPSPELVKGT	PXDNL	1431	A1KZ92
PGASQPCILEPCPGP	GALR2	356	O43603
PICINSSEKCGPPPP	CFHR3	201	Q02985
KAFIGCPPPPKTPNG	CR2	846	P20023
CGPPCPASCPSPAPL	FCGBP	4361	Q9Y6R7
PVPAKGHCPLTPGNP	IGFLR1	116	Q9H665
PKEEGLCCPPPVPSN	HUNK	631	P57058
PAPCICPPGKPGLQG	COL21A1	441	Q96P44
PARPCPTSGPPAGPC	EFS	106	O43281
KDVCNDCPPGPPGLP	COL22A1	1111	Q8NFW1
CPAKPVAPGPCFGGR	CCDC71L	161	Q8N9Z2
PKTSPGCNCPPGPPG	COL13A1	111	Q5TAT6
SAEPPKQCHPCPGVP	HOXB13	56	Q92826
KQCHPCPGVPQGTSP	HOXB13	61	Q92826
RPPCPPGAESGPQTK	FMN2	766	Q9NZ56
GSPTVPIKPPCIPNG	CAMK2D	471	Q13557
PCVPSVPCTPAPQVG	KRT36	426	O76013
GPCEPPCLCGPAPGA	PKD1	31	P98161
RSCVDPPPKNGGAPC	SSPOP	2581	A2VEC9
GPRPGCQPSSPCVPK	TRAFD1	471	O14545
RQSPGPPKGEGSCPC	TMEM132A	911	Q24JP5
PPVPCRHPGKIPGQC	KCP	351	Q6ZWJ8
PCPPAPCAHPRQGPC	KCP	706	Q6ZWJ8
GCPPSQLLPPGPQHC	KCP	1066	Q6ZWJ8
LTPPAPKGCGPPSPC	NOTCH4	1126	Q99466
TGGCPQPCAPVKPAP	RHPN1	646	Q8TCX5
SSSPGLPCQGPCAPP	C11orf87	151	Q6NUJ2
PQSFCPGCPCPGSPG	TMC8	671	Q8IU68
PGCPCPGSPGHQAPR	TMC8	676	Q8IU68
PCPEGPVPSGVPCAT	SEC16A	231	O15027
PSTGCGCPPGTEPPV	TNXB	81	P22105
VGGGCCPCPCPPQPP	SOCS7	76	O14512
AAAPAPGCCPPTPNP	VPS9D1	306	Q9Y2B5
PASQPGPCPAPGHCP	TTLL10	51	Q6ZVT0
KCVCGPSAPPAPTPP	MYO18A	51	O95411
PPPPAGGAKPCSKTF	ZIC5	421	Q96T25
SAGLGPKCPSVCPPG	KRT72	81	Q14CN4
PKCPSVCPPGGIPQV	KRT72	86	Q14CN4