Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	triacyl lipopeptide binding	TLR1 TLR2	3.58e-05	2	120	2	GO:0042497
GeneOntologyMolecularFunction	calcium ion binding	LPCAT1 CD248 SMOC1 DYSF ZZEF1 MICU1 THBD THBS2 EYS FBN2 HMCN2 SPOCK3 NCAN FBN3 NOTCH2	4.34e-05	749	120	15	GO:0005509
GeneOntologyCellularComponent	Toll-like receptor 1-Toll-like receptor 2 protein complex	TLR1 TLR2	3.32e-05	2	121	2	GO:0035354
GeneOntologyCellularComponent	external encapsulating structure	CD248 CHI3L1 SMOC1 PKHD1L1 THBS2 EYS FBN2 HMCN2 ADAMTS6 SPOCK3 NCAN FBN3 COL1A2	1.15e-04	658	121	13	GO:0030312
Domain	EGF_CA	CD248 THBD THBS2 EYS FBN2 HMCN2 NCAN FBN3 NOTCH2	8.51e-08	122	119	9	SM00179
Domain	EGF-like_Ca-bd_dom	CD248 THBD THBS2 EYS FBN2 HMCN2 NCAN FBN3 NOTCH2	9.79e-08	124	119	9	IPR001881
Domain	EGF_Ca-bd_CS	CD248 THBD EYS FBN2 HMCN2 NCAN FBN3 NOTCH2	1.93e-07	97	119	8	IPR018097
Domain	EGF_CA	CD248 THBD EYS FBN2 HMCN2 NCAN FBN3 NOTCH2	2.26e-07	99	119	8	PS01187
Domain	EGF-type_Asp/Asn_hydroxyl_site	CD248 THBD EYS FBN2 HMCN2 NCAN FBN3 NOTCH2	3.84e-07	106	119	8	IPR000152
Domain	EGF_CA	CD248 THBD THBS2 FBN2 HMCN2 FBN3 NOTCH2	1.26e-06	86	119	7	PF07645
Domain	EGF_3	CD248 THBD THBS2 EYS FBN2 HMCN2 NCAN TENM1 FBN3 NOTCH2	2.64e-06	235	119	10	PS50026
Domain	ASX_HYDROXYL	THBD EYS FBN2 HMCN2 NCAN FBN3 NOTCH2	3.50e-06	100	119	7	PS00010
Domain	EGF-like_dom	CD248 THBD THBS2 EYS FBN2 HMCN2 NCAN TENM1 FBN3 NOTCH2	4.41e-06	249	119	10	IPR000742
Domain	EGF_1	CD248 THBD THBS2 EYS FBN2 HMCN2 NCAN TENM1 FBN3 NOTCH2	5.45e-06	255	119	10	PS00022
Domain	EGF-like_CS	CD248 THBD THBS2 EYS FBN2 HMCN2 NCAN TENM1 FBN3 NOTCH2	6.69e-06	261	119	10	IPR013032
Domain	EGF_2	CD248 THBD THBS2 EYS FBN2 HMCN2 NCAN TENM1 FBN3 NOTCH2	7.64e-06	265	119	10	PS01186
Domain	EGF	CD248 THBD THBS2 EYS NCAN FBN3 NOTCH2	1.61e-05	126	119	7	PF00008
Domain	EGF	CD248 THBD THBS2 EYS FBN2 NCAN TENM1 FBN3 NOTCH2	1.97e-05	235	119	9	SM00181
Domain	hEGF	EYS FBN2 FBN3 NOTCH2	2.85e-05	28	119	4	PF12661
Domain	Growth_fac_rcpt_	CD248 THBD EYS FBN2 HMCN2 FBN3 NOTCH2	6.35e-05	156	119	7	IPR009030
Domain	Beta/gamma_crystallin	CRYBA2 CRYGN CRYBG3	1.09e-04	15	119	3	IPR001064
Domain	CRYSTALLIN_BETA_GAMMA	CRYBA2 CRYGN CRYBG3	1.09e-04	15	119	3	PS50915
Domain	Crystall	CRYBA2 CRYGN CRYBG3	1.09e-04	15	119	3	PF00030
Domain	XTALbg	CRYBA2 CRYGN CRYBG3	1.09e-04	15	119	3	SM00247
Domain	E1_4HB	UBA7 UBA6	1.20e-04	3	119	2	PF16191
Domain	E1_FCCH	UBA7 UBA6	1.20e-04	3	119	2	PF16190
Domain	UBQ-activ_enz_E1	UBA7 UBA6	1.20e-04	3	119	2	IPR018075
Domain	UBA_e1_C	UBA7 UBA6	1.20e-04	3	119	2	SM00985
Domain	Ub-activating_enz_E1_C	UBA7 UBA6	1.20e-04	3	119	2	IPR018965
Domain	E1_4HB	UBA7 UBA6	1.20e-04	3	119	2	IPR032420
Domain	E1_FCCH	UBA7 UBA6	1.20e-04	3	119	2	IPR032418
Domain	E1_UFD	UBA7 UBA6	1.20e-04	3	119	2	PF09358
Domain	FBN	FBN2 FBN3	1.20e-04	3	119	2	IPR011398
Domain	G_crystallin-rel	CRYBA2 CRYGN CRYBG3	1.92e-04	18	119	3	IPR011024
Domain	-	UBA7 UBA6	2.40e-04	4	119	2	1.10.3240.10
Domain	-	HNRNPUL1 HNRNPUL2 SAFB2	3.08e-04	21	119	3	1.10.720.30
Domain	SAP	HNRNPUL1 HNRNPUL2 SAFB2	3.56e-04	22	119	3	PF02037
Domain	UBIQUITIN_ACTIVAT_1	UBA7 UBA6	3.98e-04	5	119	2	PS00536
Domain	UBA_E1_Cys	UBA7 UBA6	3.98e-04	5	119	2	IPR019572
Domain	-	CHIA CHI3L1	3.98e-04	5	119	2	3.10.50.10
Domain	Toll-like_receptor	TLR1 TLR2	3.98e-04	5	119	2	IPR017241
Domain	Chitinase_insertion	CHIA CHI3L1	3.98e-04	5	119	2	IPR029070
Domain	UBIQUITIN_ACTIVAT_2	UBA7 UBA6	3.98e-04	5	119	2	PS00865
Domain	UBA_e1_thiolCys	UBA7 UBA6	3.98e-04	5	119	2	PF10585
Domain	SAP	HNRNPUL1 HNRNPUL2 SAFB2	4.07e-04	23	119	3	SM00513
Domain	SAP	HNRNPUL1 HNRNPUL2 SAFB2	5.24e-04	25	119	3	PS50800
Domain	SAP_dom	HNRNPUL1 HNRNPUL2 SAFB2	5.24e-04	25	119	3	IPR003034
Domain	cEGF	THBD FBN2 FBN3	5.89e-04	26	119	3	PF12662
Domain	cEGF	THBD FBN2 FBN3	5.89e-04	26	119	3	IPR026823
Domain	DCX	DCLK2 DCLK1	5.94e-04	6	119	2	SM00537
Domain	Glyco_hydro_18_chit_AS	CHIA CHI3L1	5.94e-04	6	119	2	IPR001579
Domain	UBQ/SUMO-activ_enz_E1-like	UBA7 UBA6	5.94e-04	6	119	2	IPR000011
Domain	Glyco_hydro18_cat	CHIA CHI3L1	8.28e-04	7	119	2	IPR001223
Domain	-	DCLK2 DCLK1	8.28e-04	7	119	2	3.10.20.230
Domain	TB	FBN2 FBN3	8.28e-04	7	119	2	PF00683
Domain	Notch_dom	PAPPA NOTCH2	8.28e-04	7	119	2	IPR000800
Domain	Glyco_hydro_18	CHIA CHI3L1	8.28e-04	7	119	2	PF00704
Domain	Chitinase_II	CHIA CHI3L1	8.28e-04	7	119	2	IPR011583
Domain	Glyco_18	CHIA CHI3L1	8.28e-04	7	119	2	SM00636
Domain	DCX	DCLK2 DCLK1	8.28e-04	7	119	2	PF03607
Domain	Notch	PAPPA NOTCH2	8.28e-04	7	119	2	PF00066
Domain	CHITINASE_18	CHIA CHI3L1	8.28e-04	7	119	2	PS01095
Domain	NL	PAPPA NOTCH2	8.28e-04	7	119	2	SM00004
Domain	TIG	CAMTA2 PLXND1 PKHD1L1	9.95e-04	31	119	3	PF01833
Domain	IPT	CAMTA2 PLXND1 PKHD1L1	1.09e-03	32	119	3	IPR002909
Domain	SPARC/Testican_Ca-bd-dom	SMOC1 SPOCK3	1.10e-03	8	119	2	IPR019577
Domain	-	FBN2 FBN3	1.10e-03	8	119	2	3.90.290.10
Domain	DC	DCLK2 DCLK1	1.10e-03	8	119	2	PS50309
Domain	GDA1_CD39_NTPase	ENTPD5 ENTPD8	1.10e-03	8	119	2	IPR000407
Domain	SPARC_Ca_bdg	SMOC1 SPOCK3	1.10e-03	8	119	2	PF10591
Domain	GDA1_CD39	ENTPD5 ENTPD8	1.10e-03	8	119	2	PF01150
Domain	GDA1_CD39_NTPASE	ENTPD5 ENTPD8	1.10e-03	8	119	2	PS01238
Domain	Doublecortin_dom	DCLK2 DCLK1	1.10e-03	8	119	2	IPR003533
Domain	TB_dom	FBN2 FBN3	1.41e-03	9	119	2	IPR017878
Domain	TB	FBN2 FBN3	1.41e-03	9	119	2	PS51364
Domain	ThiF_NAD_FAD-bd	UBA7 UBA6	1.75e-03	10	119	2	IPR000594
Domain	ThiF	UBA7 UBA6	1.75e-03	10	119	2	PF00899
Domain	EF-hand-dom_pair	CACNA1F SYNRG LPCAT1 SMOC1 ZZEF1 MICU1 SPOCK3	2.44e-03	287	119	7	IPR011992
Domain	KAZAL	SMOC1 SPOCK3 SPINK6	3.14e-03	46	119	3	SM00280
Domain	KAZAL_2	SMOC1 SPOCK3 SPINK6	3.97e-03	50	119	3	PS51465
Domain	Kazal_dom	SMOC1 SPOCK3 SPINK6	4.20e-03	51	119	3	IPR002350
Domain	-	SMOC1 SPOCK3	5.14e-03	17	119	2	4.10.800.10
Domain	Thyroglobulin_1	SMOC1 SPOCK3	5.14e-03	17	119	2	IPR000716
Domain	THYROGLOBULIN_1_1	SMOC1 SPOCK3	5.14e-03	17	119	2	PS00484
Domain	TY	SMOC1 SPOCK3	5.14e-03	17	119	2	SM00211
Domain	THYROGLOBULIN_1_2	SMOC1 SPOCK3	5.14e-03	17	119	2	PS51162
Domain	Thyroglobulin_1	SMOC1 SPOCK3	5.14e-03	17	119	2	PF00086
Domain	SUSHI	CD248 NCAN PAPPA	5.47e-03	56	119	3	PS50923
Domain	Sushi_SCR_CCP_dom	CD248 NCAN PAPPA	5.75e-03	57	119	3	IPR000436
Domain	ZF_ZZ_2	ZZEF1 EP300	5.76e-03	18	119	2	PS50135
Domain	ZF_ZZ_1	ZZEF1 EP300	5.76e-03	18	119	2	PS01357
Domain	Terpenoid_cyclase/PrenylTrfase	TCN2 RABGGTB	5.76e-03	18	119	2	IPR008930
Domain	ZZ	ZZEF1 EP300	5.76e-03	18	119	2	PF00569
Pubmed	TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS.	TLR1 TLR2 IL6	8.36e-07	6	122	3	32652111
Pubmed	Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue.	TLR1 TLR2 IL6	8.36e-07	6	122	3	18292749
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	SYNRG RANBP2 MIA3 HK2 RAB11FIP2 SCRN1 PSMD13 MICU1 EEF1G HNRNPUL2 TENM1 DCLK2 CRYBG3 CPNE4 DCLK1 HDAC2	2.51e-06	1139	122	16	36417873
Pubmed	Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis.	TLR1 TLR2 IL6	4.96e-06	10	122	3	19122641
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	HK2 TOR2A PPP1R12B POLR2A PLXND1 HARS2 ADAMTS6 UBA6 DMPK EP300 ENTPD8 HDAC2	1.06e-05	730	122	12	34857952
Pubmed	Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice.	TLR1 TLR2	1.22e-05	2	122	2	12091878
Pubmed	HDAC2-mediated upregulation of IL-6 triggers the migration of osteosarcoma cells.	IL6 HDAC2	1.22e-05	2	122	2	30706385
Pubmed	Mycobacterium tuberculosis lipoproteins directly regulate human memory CD4(+) T cell activation via Toll-like receptors 1 and 2.	TLR1 TLR2	1.22e-05	2	122	2	21078852
Pubmed	Toll-like receptor-2 and interleukin-6 mediate cardiomyocyte protection from apoptosis during Trypanosoma cruzi murine infection.	TLR2 IL6	1.22e-05	2	122	2	21984337
Pubmed	Cutaneous innate immune sensing of Toll-like receptor 2-6 ligands suppresses T cell immunity by inducing myeloid-derived suppressor cells.	TLR2 IL6	1.22e-05	2	122	2	25456159
Pubmed	Identification of microRNAs that regulate TLR2-mediated trophoblast apoptosis and inhibition of IL-6 mRNA.	TLR2 IL6	1.22e-05	2	122	2	24143215
Pubmed	Interleukin-6 and YKL-40 predicted recurrent stroke after ischemic stroke or TIA: analysis of 6 inflammation biomarkers in a prospective cohort study.	CHI3L1 IL6	1.22e-05	2	122	2	35761288
Pubmed	Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of toll-like receptors 1 and 2.	TLR1 TLR2	1.22e-05	2	122	2	15793154
Pubmed	Nasal airway epithelial cell IL-6 and FKBP51 gene expression and steroid sensitivity in asthmatic children.	FKBP5 IL6	1.22e-05	2	122	2	28493984
Pubmed	Association of Toll-like receptor 2 Arg753Gln and Toll-like receptor 1 Ile602Ser single-nucleotide polymorphisms with leptospirosis in an Argentine population.	TLR1 TLR2	1.22e-05	2	122	2	25784560
Pubmed	Association between risk of asthma and gene polymorphisms in CHI3L1 and CHIA: a systematic meta-analysis.	CHIA CHI3L1	1.22e-05	2	122	2	29233108
Pubmed	Brucella abortus inhibits major histocompatibility complex class II expression and antigen processing through interleukin-6 secretion via Toll-like receptor 2.	TLR2 IL6	1.22e-05	2	122	2	17984211
Pubmed	Prognostic Value of Combined Detection of Serum IL6, YKL-40, and C-reactive Protein in Patients with Unresectable Pancreatic Cancer.	CHI3L1 IL6	1.22e-05	2	122	2	31685562
Pubmed	Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide.	TLR1 TLR2	1.22e-05	2	122	2	17889651
Pubmed	The toll-like receptor 2/1 (TLR2/1) complex initiates human platelet activation via the src/Syk/LAT/PLCγ2 signalling cascade.	TLR1 TLR2	1.22e-05	2	122	2	24240055
Pubmed	Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling.	TLR1 TLR2	1.22e-05	2	122	2	16455995
Pubmed	Age-associated defect in human TLR-1/2 function.	TLR1 TLR2	1.22e-05	2	122	2	17202359
Pubmed	The oxidative stress product carboxyethylpyrrole potentiates TLR2/TLR1 inflammatory signaling in macrophages.	TLR1 TLR2	1.22e-05	2	122	2	25184331
Pubmed	Aftiphilin and gamma-synergin are required for secretagogue sensitivity of Weibel-Palade bodies in endothelial cells.	SYNRG AFTPH	1.22e-05	2	122	2	18815278
Pubmed	Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair.	HNRNPUL1 HNRNPUL2	1.22e-05	2	122	2	22365830
Pubmed	Toll-like receptor 2 is upregulated by hog confinement dust in an IL-6-dependent manner in the airway epithelium.	TLR2 IL6	1.22e-05	2	122	2	18359883
Pubmed	Toll- like receptor 2 polymorphism and IL-6 profile in relation to disease progression in chronic HBV infection: a case control study in Egyptian patients.	TLR2 IL6	1.22e-05	2	122	2	35119591
Pubmed	Immunohistochemical study of Toll-like receptors 1 and 2 expression in cutaneous lichen planus lesions.	TLR1 TLR2	1.22e-05	2	122	2	22842950
Pubmed	Toll-like receptors 1 and 2 heterodimers alter Borrelia burgdorferi gene expression in mice and ticks.	TLR1 TLR2	1.22e-05	2	122	2	19754309
Pubmed	Genetic Variants in CHIA and CHI3L1 Are Associated with the IgE Response to the Ascaris Resistance Marker ABA-1 and the Birch Pollen Allergen Bet v 1.	CHIA CHI3L1	1.22e-05	2	122	2	27977724
Pubmed	Establishment of a quantitative PCR system for discriminating chitinase-like proteins: catalytically inactive breast regression protein-39 and Ym1 are constitutive genes in mouse lung.	CHIA CHI3L1	1.22e-05	2	122	2	25294623
Pubmed	Carrying both COL1A2 and FBN2 gene heterozygous mutations results in a severe skeletal clinical phenotype: an affected family.	FBN2 COL1A2	1.22e-05	2	122	2	35804365
Pubmed	Diagnostic and Prognostic Impact of Circulating YKL-40, IL-6, and CA 19.9 in Patients with Pancreatic Cancer.	CHI3L1 IL6	1.22e-05	2	122	2	23840582
Pubmed	Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation.	DCLK2 DCLK1	1.22e-05	2	122	2	23385585
Pubmed	Campylobacter jejuni drives MyD88-independent interleukin-6 secretion via Toll-like receptor 2.	TLR2 IL6	1.22e-05	2	122	2	19139198
Pubmed	TLR1/TLR2 agonist induces tumor regression by reciprocal modulation of effector and regulatory T cells.	TLR1 TLR2	1.22e-05	2	122	2	21217015
Pubmed	TLR1/2 orchestrate human plasmacytoid predendritic cell response to gram+ bacteria.	TLR1 TLR2	1.22e-05	2	122	2	31017904
Pubmed	Prediction of Unresectability and Prognosis in Patients Undergoing Surgery on Suspicion of Pancreatic Cancer Using Carbohydrate Antigen 19-9, Interleukin 6, and YKL-40.	CHI3L1 IL6	1.22e-05	2	122	2	31856080
Pubmed	Recent insights into the role of Toll-like receptors in viral infection.	TLR1 TLR2	1.22e-05	2	122	2	20560984
Pubmed	Toll-like receptors 1 and 2 cooperatively mediate immune responses to curli, a common amyloid from enterobacterial biofilms.	TLR1 TLR2	1.22e-05	2	122	2	20497180
Pubmed	A triacylated lipoprotein from Mycoplasma genitalium activates NF-kappaB through Toll-like receptor 1 (TLR1) and TLR2.	TLR1 TLR2	1.22e-05	2	122	2	18474641
Pubmed	Increased levels of YKL-40 and interleukin 6 in patients with chronic pancreatitis and secondary diabetes.	CHI3L1 IL6	1.22e-05	2	122	2	22647735
Pubmed	Correlation of polymorphism in Toll-Like Receptor (TLR1 and TLR2) genes with susceptibility of pulmonary tuberculosis in Doda region of India.	TLR1 TLR2	1.22e-05	2	122	2	38296390
Pubmed	Altered tonsillar toll-like receptor (TLR)-1 and TLR-2 expression levels between periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA), and group A beta-hemolytic streptococcal (GAβHS) recurrent tonsillitis patients.	TLR1 TLR2	1.22e-05	2	122	2	33725589
Pubmed	TLR2/1 and sphingosine 1-phosphate modulate inflammation, myofibroblast differentiation and cell migration in fibroblasts.	TLR1 TLR2	1.22e-05	2	122	2	24440818
Pubmed	Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction.	TLR1 TLR2	1.22e-05	2	122	2	18461142
Pubmed	Toll-like receptor 2 signalling: Significance in megakaryocyte development through wnt signalling cross-talk and cytokine induction.	TLR2 IL6	1.22e-05	2	122	2	27179140
Pubmed	Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling.	TLR1 TLR2	1.22e-05	2	122	2	12975352
Pubmed	Regulation of toll-like receptor 1 and -2 in neonatal mice brains after hypoxia-ischemia.	TLR1 TLR2	1.22e-05	2	122	2	21569241
Pubmed	ATP-stimulated interleukin-6 synthesis through P2Y receptors on human osteoblasts.	LPAR6 IL6	1.22e-05	2	122	2	15582581
Pubmed	Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling.	TLR1 TLR2	1.22e-05	2	122	2	16893894
Pubmed	Neisseria lactamica attenuates TLR-1/2-induced cytokine responses in nasopharyngeal epithelial cells using PPAR-γ.	TLR1 TLR2	3.65e-05	3	122	2	21105983
Pubmed	Landscape of Cell Communication in Human Dental Pulp.	TLR1 TLR2	3.65e-05	3	122	2	34928049
Pubmed	Fungal exposure modulates the effect of polymorphisms of chitinases on emergency department visits and hospitalizations.	CHIA CHI3L1	3.65e-05	3	122	2	20538957
Pubmed	Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease.	TLR1 TLR2	3.65e-05	3	122	2	16081826
Pubmed	Sublethal infection of C57BL/6 mice with Salmonella enterica Serovar Typhimurium leads to an increase in levels of Toll-like receptor 1 (TLR1), TLR2, and TLR9 mRNA as well as a decrease in levels of TLR6 mRNA in infected organs.	TLR1 TLR2	3.65e-05	3	122	2	15731092
Pubmed	The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases.	CHIA CHI3L1	3.65e-05	3	122	2	19644363
Pubmed	Ureaplasma parvum lipoproteins, including MB antigen, activate NF-{kappa}B through TLR1, TLR2 and TLR6.	TLR1 TLR2	3.65e-05	3	122	2	18451040
Pubmed	TLR1- and TLR6-independent recognition of bacterial lipopeptides.	TLR1 TLR2	3.65e-05	3	122	2	16455646
Pubmed	Gender-dependent histone deacetylases injury may contribute to differences in liver recovery rates of male and female mice.	TLR2 HDAC2	3.65e-05	3	122	2	23498780
Pubmed	A dipalmitoylated lipoprotein from Mycoplasma pneumoniae activates NF-kappa B through TLR1, TLR2, and TLR6.	TLR1 TLR2	3.65e-05	3	122	2	16177110
Pubmed	Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2.	TLR1 TLR2	3.65e-05	3	122	2	18006661
Pubmed	Importance of Water Content of the Stratum Corneum in Mouse Models for Contact Hypersensitivity.	TLR1 TLR2	3.65e-05	3	122	2	27650608
Pubmed	Relationships between increased circulating YKL-40, IL-6 and TNF-α levels and phenotypes and disease activity of primary Sjögren's syndrome.	CHI3L1 IL6	3.65e-05	3	122	2	32791244
Pubmed	TWIST1-EP300 Expedites Gastric Cancer Cell Resistance to Apatinib by Activating the Expression of COL1A2.	EP300 COL1A2	3.65e-05	3	122	2	35242497
Pubmed	TLR expression on neutrophils at the pulmonary site of infection: TLR1/TLR2-mediated up-regulation of TLR5 expression in cystic fibrosis lung disease.	TLR1 TLR2	3.65e-05	3	122	2	18684966
Pubmed	Enteroendocrine cells express functional Toll-like receptors.	TLR1 TLR2	3.65e-05	3	122	2	17395901
Pubmed	TLR 2 induces vascular smooth muscle cell migration through cAMP response element-binding protein-mediated interleukin-6 production.	TLR2 IL6	3.65e-05	3	122	2	22995520
Pubmed	Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator.	EP300 COL1A2	3.65e-05	3	122	2	19395477
Pubmed	Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex.	OBSCN OBSL1	3.65e-05	3	122	2	20133654
Pubmed	Divergent roles of amino acid residues inside and outside the BB loop affect human Toll-like receptor (TLR)2/2, TLR2/1 and TLR2/6 responsiveness.	TLR1 TLR2	3.65e-05	3	122	2	23626692
Pubmed	Farnesol promotes epithelial cell defense against Candida albicans through Toll-like receptor 2 expression, interleukin-6 and human beta-defensin 2 production.	TLR2 IL6	3.65e-05	3	122	2	19121950
Pubmed	IL-6 and maturation govern TLR2 and TLR4 induced TLR agonist tolerance and cross-tolerance in dendritic cells.	TLR2 IL6	3.65e-05	3	122	2	17947654
Pubmed	ATRA activates and PDGF-BB represses the SM22α promoter through KLF4 binding to, or dissociating from, its cis-DNA elements.	EP300 HDAC2	3.65e-05	3	122	2	21252119
Pubmed	TLR2 expression in relation to IL-6 and IL-1beta and their natural regulators production by PMN and PBMC in patients with Lyme disease.	TLR2 IL6	3.65e-05	3	122	2	16864901
Pubmed	Toll-like receptor 2 subfamily gene polymorphisms are associated with Bacillus Calmette-Guérin osteitis following newborn vaccination.	TLR1 TLR2	3.65e-05	3	122	2	25605403
Pubmed	Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.	TLR1 TLR2	3.65e-05	3	122	2	14966134
Pubmed	Toll-like receptor 2 subfamily genotypes are not associated with severity of bronchiolitis or postbronchiolitis wheezing in infants.	TLR1 TLR2	3.65e-05	3	122	2	24112285
Pubmed	A role for TLR1, TLR2 and NOD2 in cytokine induction by Bacteroides fragilis.	TLR1 TLR2	3.65e-05	3	122	2	22998942
Pubmed	Polymorphisms of chitinases are not associated with asthma.	CHIA CHI3L1	3.65e-05	3	122	2	20226308
Pubmed	The tumor suppressor p53 abrogates Smad-dependent collagen gene induction in mesenchymal cells.	EP300 COL1A2	3.65e-05	3	122	2	15345715
Pubmed	Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins.	TLR1 TLR2	3.65e-05	3	122	2	12077222
Pubmed	Association of plasma YKL-40 with brain amyloid-β levels, memory performance, and sex in subjective memory complainers.	CHI3L1 IL6	3.65e-05	3	122	2	32920471
Pubmed	Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling.	TLR1 TLR2	3.65e-05	3	122	2	18056480
Pubmed	Acetylation inactivates the transcriptional repressor BCL6.	EP300 HDAC2	3.65e-05	3	122	2	12402037
Pubmed	TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes.	TLR1 TLR2	3.65e-05	3	122	2	21998742
Pubmed	Lactobacillus johnsonii alleviates colitis by TLR1/2-STAT3 mediated CD206+ macrophagesIL-10 activation.	TLR1 TLR2	3.65e-05	3	122	2	36398889
Pubmed	IL-6, but not TNF-α, increases plasma YKL-40 in human subjects.	CHI3L1 IL6	3.65e-05	3	122	2	21478032
Pubmed	Soluble Toll-like receptor 1 family members in the amniotic fluid of women with preterm prelabor rupture of the membranes.	TLR1 TLR2	3.65e-05	3	122	2	22280448
Pubmed	Serum IL6 as a Prognostic Biomarker and IL6R as a Therapeutic Target in Biliary Tract Cancers.	CHI3L1 IL6	3.65e-05	3	122	2	32933994
Pubmed	Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection.	OBSCN OBSL1	3.65e-05	3	122	2	27989621
Pubmed	Statins fail to improve outcome in experimental cerebral malaria and potentiate Toll-like receptor-mediated cytokine production by murine macrophages.	TLR2 IL6	3.65e-05	3	122	2	19815878
Pubmed	Chitinase effects on immune cell response in neuromyelitis optica and multiple sclerosis.	CHIA CHI3L1	3.65e-05	3	122	2	21159721
Pubmed	Associations of Toll-Like Receptor and β-Defensin Polymorphisms with Measures of Periodontal Disease (PD) in HIV+ North American Adults: An Exploratory Study.	TLR1 TLR2	3.65e-05	3	122	2	27727278
Pubmed	Cross-talk between 4-1BB and TLR1-TLR2 Signaling in CD8+ T Cells Regulates TLR2's Costimulatory Effects.	TLR1 TLR2	3.65e-05	3	122	2	27267778
Pubmed	CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the receptor complex of Toll-like receptors 2 and 1 without binding to the complex.	TLR1 TLR2	3.65e-05	3	122	2	16848791
Pubmed	CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha.	CITED4 EP300	3.65e-05	3	122	2	15342390
Pubmed	Thrombomodulin's lectin-like domain reduces myocardial damage by interfering with HMGB1-mediated TLR2 signalling.	THBD TLR2	3.65e-05	3	122	2	24323314
Pubmed	Evaluation of tool-like receptor-2 and 4 and interleukin-6 gene expressions in Turkish rheumatoid arthritis patients.	TLR2 IL6	3.65e-05	3	122	2	27108590
Pubmed	Recognition of Coxiella burnetii by toll-like receptors and nucleotide-binding oligomerization domain-like receptors.	TLR1 TLR2	3.65e-05	3	122	2	25246533
GeneFamily	Chitinases	CHIA CHI3L1	4.10e-04	7	81	2	816
GeneFamily	SPARC family	SMOC1 SPOCK3	5.45e-04	8	81	2	1278
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CD248 THBD NCAN	8.17e-04	41	81	3	1298
GeneFamily	CD molecules\|Toll like receptors	TLR1 TLR2	8.72e-04	10	81	2	948
GeneFamily	Ubiquitin like modifier activating enzymes	UBA7 UBA6	8.72e-04	10	81	2	100
GeneFamily	Doublecortin superfamily	DCLK2 DCLK1	8.72e-04	10	81	2	1369
GeneFamily	Beta-gamma crystallins	CRYBA2 CRYGN	2.00e-03	15	81	2	1359
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	ZZEF1 EP300	2.90e-03	18	81	2	91
Coexpression	NABA_CORE_MATRISOME	SMOC1 THBS2 EYS FBN2 HMCN2 SPOCK3 NCAN VWA3B FBN3 COL1A2	6.74e-07	275	122	10	M5884
CoexpressionAtlas	dev gonad_e11.5_M_GonadVasMes_Flk_top-relative-expression-ranked_1000	HK2 CD248 POLD2 RAB11FIP2 OBSL1 SCRN1 SMOC1 MICU1 RGL1 FBN2 SERINC5 CLSPN FKBP5 DCLK1 NOTCH2 COL1A2	1.38e-05	827	118	16	gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_1000
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CD248 TMPRSS6 THBD CPNE4 IL6 DCLK1 COL1A2	7.98e-07	185	122	7	d5f5866924648a3c14e2596218fd548a31777aa3
ToppCell	(1)_Control_(PBS)-(1)_VE-Cad+_vascular_cells\|World / Stress and Cell class	TCN2 ATP8B1 PLXND1 RGL1 THBD CRYGN LPAR6	1.13e-06	195	122	7	6b5d3ecec0c00ebfc889dc6235390ff53b5c0b6a
ToppCell	COVID-19-kidney-Technical/muscle\|kidney / Disease (COVID-19 only), tissue and cell type	NKAIN2 EYS FBN2 CPNE4 CLSPN DNAH8	3.38e-06	148	122	6	0dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(NPW+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RIMKLA ADH6 CRYBA2 AGBL4 EYS CPNE4	4.41e-06	155	122	6	498e52e2364ff44d3c0c707ba22468217031f5bd
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAMTA2 DYSF ALKBH1 UBE3D CRYGN DMPK	8.01e-06	172	122	6	574ebdf36e45222bcd907cd2c2ee7ff50ed4573a
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAMTA2 DYSF ALKBH1 UBE3D CRYGN DMPK	8.01e-06	172	122	6	1627fa7035b0e0bbc82a1c0f000d8231254c680a
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TMPRSS6 SMOC1 THBS2 CLSPN DCLK1 COL1A2	9.43e-06	177	122	6	4197cf2b1e743230c821f422836fa5991b155a52
ToppCell	P28-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HK2 CD248 HMCN2 IL6 DCLK1 COL1A2	1.04e-05	180	122	6	9adebde5f4ca6dcb90e9113622862e14298465ac
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1F OBSCN NKAIN2 PKHD1L1 FBN2 TENM1	1.18e-05	184	122	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1F OBSCN NKAIN2 PKHD1L1 FBN2 TENM1	1.18e-05	184	122	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1F OBSCN NKAIN2 PKHD1L1 FBN2 TENM1	1.18e-05	184	122	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 GRB10 THBD THBS2 IL6 COL1A2	1.21e-05	185	122	6	3cd0686a14e734a0f243070ab939adcb4c454478
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 GRB10 THBD THBS2 IL6 COL1A2	1.21e-05	185	122	6	00258f458cbf6d36449db95528a6b5038d731d2d
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 GRB10 THBD THBS2 IL6 COL1A2	1.21e-05	185	122	6	a94694e226856bc5b168464f52d76004145717a5
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1F SMOC1 DYSF NKAIN2 PKHD1L1 GJD3	1.21e-05	185	122	6	241ea1e178fffef9e7df971de739e794332d5173
ToppCell	Tuft\|World / Class top	CHI3L1 SMOC1 CRYBA2 CITED4 GNB3 DCLK1	1.25e-05	186	122	6	f4d83f15ab7b49c0920a322cd832413ece7c9948
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 PKHD1L1 FBN2 CRYGN PAPPA COL1A2	1.29e-05	187	122	6	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 PKHD1L1 FBN2 CRYGN PAPPA COL1A2	1.29e-05	187	122	6	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 PKHD1L1 FBN2 CRYGN PAPPA COL1A2	1.29e-05	187	122	6	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	Tuft-tuft-2\|World / Class top	CHI3L1 SMOC1 CRYBA2 CITED4 GNB3 DCLK1	1.29e-05	187	122	6	4ec6eee866619dfe13c84f5d2e812bb380d37139
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	PPP1R12B OBSCN DYSF NKAIN2 AGBL4 ALPK2	1.33e-05	188	122	6	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	Fibroblast-C\|World / shred on cell class and cell subclass (v4)	CD248 GRB10 THBS2 FBN2 DCLK1 COL1A2	1.37e-05	189	122	6	58e0400fbab5a0755504275aef5cf7986149abab
ToppCell	RA-14._Fibroblast_III\|RA / Chamber and Cluster_Paper	RANBP2 GRB10 THBS2 PAPPA IL6 DCLK1	1.37e-05	189	122	6	46e9a58aacd79db5a02898a8c7244e1884adcfd1
ToppCell	RA-14._Fibroblast_III\|World / Chamber and Cluster_Paper	RANBP2 GRB10 THBS2 PAPPA IL6 DCLK1	1.37e-05	189	122	6	b6e12d24d2b0735730bdc625f8318c1c9c2a9b3b
ToppCell	ASK428-Epithelial-Transformed_epithelium\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	CD248 PKHD1L1 THBS2 PAPPA IL6 COL1A2	1.37e-05	189	122	6	87189275234b5d59484c58acbb14a09903f2b578
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPP1R12B SMOC1 THBS2 HMCN2 DCLK1 COL1A2	1.41e-05	190	122	6	2e88e366d377d74deb53a4ea870973ce5c6532e8
ToppCell	(2)_5-FU-(1)_VE-Cad+_vascular_cells\|World / Stress and Cell class	TCN2 PLXND1 RGL1 THBD CRYGN LPAR6	1.41e-05	190	122	6	6b391b8a3ffcbdec3acaf242bc52fc3fc9da77c8
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal-mesenchymal_stem_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HK2 CD248 TMPRSS6 THBD IL6 COL1A2	1.41e-05	190	122	6	d13fd234caa3fc69d8a59bc0060cdacdf716ee55
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPP1R12B SMOC1 THBS2 HMCN2 DCLK1 COL1A2	1.41e-05	190	122	6	0028f886c789ba238c031eae5d96acaed4af8c25
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CD248 GRB10 THBS2 FBN2 DCLK1 COL1A2	1.50e-05	192	122	6	ad48c941a3ddfd9a5146bafc2209da577bb50531
ToppCell	(1)_Control_(PBS)-(1)_VE-Cad+_vascular_cells\|(1)_Control_(PBS) / Stress and Cell class	ATP8B1 PLXND1 RGL1 THBD CRYGN LPAR6	1.50e-05	192	122	6	e16e49b302019474232ef4cc0ff217d33afe34cf
ToppCell	facs-Aorta-Heart-3m-Mesenchymal\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 THBS2 DMPK DCLK1 ALPK2 COL1A2	1.50e-05	192	122	6	0dc1f46e40346ed0b286e53b106a812441575100
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRB10 ATP8B1 DYSF THBD ADAMTS6 DCLK2	1.54e-05	193	122	6	6e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCell	(07)_Brush\|World / shred by cell type and Timepoint	CHI3L1 SMOC1 CRYBA2 CITED4 GNB3 DCLK1	1.54e-05	193	122	6	9af9d22a130ff97a9c37142a65e841b056d08640
ToppCell	LV-10._Endothelium_II\|LV / Chamber and Cluster_Paper	SLC26A3 GRB10 ATP8B1 PLXND1 SMOC1 PKHD1L1	1.59e-05	194	122	6	b6cc849fa08599bff9839ef382d190cc964e273e
ToppCell	COVID-19-Heart-Fib_2\|Heart / Disease (COVID-19 only), tissue and cell type	THBS2 HMCN2 PAPPA DCLK1 NOTCH2 COL1A2	1.59e-05	194	122	6	d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCell	(4)_Endothelial_cells-(42)_EC-sinusoidal\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	TCN2 PLXND1 RGL1 THBD CRYGN LPAR6	1.59e-05	194	122	6	4428b472c2042f88eae028b1770767512a515b75
ToppCell	facs-Aorta-Heart-3m-Endothelial-aorta_endothelial_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LPCAT1 TCN2 PLXND1 DYSF RGL1 FKBP5	1.63e-05	195	122	6	3969b8d5fcec8ef1831531a781f7bbcebab5a4ba
ToppCell	ASK428-Epithelial-Transformed_epithelium\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	CD248 PKHD1L1 THBS2 PAPPA IL6 COL1A2	1.63e-05	195	122	6	c750602c765a51075ba6ede78e3ba80b62374481
ToppCell	facs-Trachea\|facs / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HK2 CD248 TMPRSS6 THBS2 IL6 COL1A2	1.68e-05	196	122	6	8209f2b0f7efebaaf81d642d18a1aee8a9a8dcf6
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts-Subpleural_fibroblasts_L.2.1.5.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD248 THBS2 CRYGN PAPPA DCLK1 COL1A2	1.68e-05	196	122	6	46d665de09f8164690b9a3e0acf0b0afa3f81b3d
ToppCell	facs-Trachea\|facs / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HK2 CD248 TMPRSS6 THBS2 IL6 COL1A2	1.68e-05	196	122	6	34020d6553309daa269dff05de0a8567211ea4d2
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRB10 PLXND1 DYSF THBD ADAMTS6 DCLK2	1.68e-05	196	122	6	e224338490691d92c1f70b57112fabdcc92b06a9
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRB10 PLXND1 DYSF THBD ADAMTS6 DCLK2	1.73e-05	197	122	6	c10dd1aaec01fb662eac83dfde90e3e426665d65
ToppCell	distal-mesenchymal-Lipofibroblast-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CD248 THBS2 CRYGN PAPPA DCLK1 COL1A2	1.73e-05	197	122	6	865010edcd7e3f79f505fcef7b33882095994aa8
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARHGAP24 CD248 GRB10 THBS2 FBN2 COL1A2	1.73e-05	197	122	6	26475b9e4d6bfc0ae818dea13d139888ed7e92f1
ToppCell	distal-mesenchymal-Lipofibroblast\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CD248 THBS2 CRYGN PAPPA DCLK1 COL1A2	1.73e-05	197	122	6	ceb83bdef16b58ee16193413bfb006f7715728b2
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRB10 PLXND1 DYSF THBD ADAMTS6 DCLK2	1.73e-05	197	122	6	2844dbcd0a673ed81c99920aa45858651a00736d
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARHGAP24 CD248 GRB10 THBS2 FBN2 COL1A2	1.73e-05	197	122	6	155e63b33302a87393ace699b2f6d73abe9c5763
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARHGAP24 CD248 GRB10 THBS2 FBN2 COL1A2	1.78e-05	198	122	6	a4005a49cf6709b543994ceb51ecd5dc46197fa9
ToppCell	Non-neuronal-Postmitotic-Mural-Mural\|World / Primary Cells by Cluster	CD248 PLXND1 DYSF THBD LPAR6 COL1A2	1.78e-05	198	122	6	9fc1035ea447a4551a66944c869c4671e17cec61
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARHGAP24 CD248 GRB10 THBS2 FBN2 COL1A2	1.78e-05	198	122	6	a699b365d3b6149f13f02b2e2ae9b6fdce761848
ToppCell	Non-neuronal-Postmitotic-Mural\|World / Primary Cells by Cluster	CD248 PLXND1 DYSF THBD LPAR6 COL1A2	1.78e-05	198	122	6	dd38840a96171f58da243daa22b013e15a81db4a
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts-Subpleural_fibroblasts_L.2.1.5.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD248 CHI3L1 THBS2 IL6 DCLK1 COL1A2	1.78e-05	198	122	6	c66097ae9ba0b50561083c423565665958ef0bb8
ToppCell	Non-neuronal-Postmitotic-Mural-Mural-18\|World / Primary Cells by Cluster	CD248 PLXND1 DYSF THBD LPAR6 COL1A2	1.78e-05	198	122	6	21efb7bcd24f24d20791b34e75d6f9d46a129481
ToppCell	mLN-(4)_Monocyte\|mLN / shred on region, Cell_type, and subtype	TCN2 CHI3L1 DYSF THBD FBN2 TLR2	1.83e-05	199	122	6	6795ff31f92580195c9db776951f99d647484d24
ToppCell	mLN-Monocyte\|mLN / Region, Cell class and subclass	TCN2 CHI3L1 DYSF THBD FBN2 TLR2	1.83e-05	199	122	6	241f790cd5d8a9b2451333deecc826a673bae70a
ToppCell	mLN-Monocyte-Monocyte\|mLN / Region, Cell class and subclass	TCN2 CHI3L1 DYSF THBD FBN2 TLR2	1.83e-05	199	122	6	dcee372774c169a3048bdaed3734b3215bf8ffad
ToppCell	mLN-(4)_Monocyte-(40)_Monocyte\|mLN / shred on region, Cell_type, and subtype	TCN2 CHI3L1 DYSF THBD FBN2 TLR2	1.83e-05	199	122	6	bcbb1eee8d79bf670dbe113094c3a292b135ce2f
ToppCell	Biopsy_Other_PF-Mesenchymal-PLIN2+_Fibroblasts\|Biopsy_Other_PF / Sample group, Lineage and Cell type	CD248 THBS2 PAPPA IL6 DCLK1 COL1A2	1.89e-05	200	122	6	0aa316b71f195ecf17ee897e307f8928a755a637
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD248 THBS2 PAPPA IL6 DCLK1 COL1A2	1.89e-05	200	122	6	d64895354218ebd0217011bae0967a6883bbd1cd
ToppCell	Posterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CACNA1F WAS DENND1C TLR1 IL6	2.64e-05	127	122	5	0750743574c2fca8df07e11d73e8b94579209609
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Macroglial-Astrocyte\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	WAS CD248 CHI3L1 ADAMTS6 UBE3D	4.50e-05	142	122	5	85e573616e54d41391b4ad8c3d38e4ca92112673
ToppCell	COVID-19-kidney-Technical/muscle_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	NKAIN2 EYS FBN2 SPOCK3 CPNE4	5.13e-05	146	122	5	c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NKAIN2 EYS SPOCK3 CPNE4 DNAH8	5.48e-05	148	122	5	d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCell	frontal_cortex\|World / Per Region, Lineage, Cell class, Cell type, Cell subtype	DYSF PTPRO TENM1 VWA3B CPNE4	6.21e-05	152	122	5	f9c29d4568402ca07a717dbffb3ccc7f35c5fe56
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	WAS POLR2A ATP8B1 RGL1 PTPRO	6.61e-05	154	122	5	ba55a63cfa5e0fb9dfec794f80078a2f0d03d0ad
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Lypd1_Gpr88\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ATP8B1 PLXND1 CRYBA2 AGBL4 CPNE4	7.24e-05	157	122	5	5aee90ad7aaa65fdabc23597451da5e48db8f4e6
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	NKAIN2 EYS SPOCK3 CPNE4 DNAH8	7.69e-05	159	122	5	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	10x5'v1-week_17-19-Hematopoietic-HSC/MPP_and_pro-HSC/MPP\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CACNA1F OBSL1 NKAIN2 SPOCK3 C1QTNF4	8.16e-05	161	122	5	aee74a2e7a8acd2950341963f1c04b59c7862183
ToppCell	droplet-Fat-Scat-21m\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 TMPRSS6 POLR2A CITED4 FBN2	9.16e-05	165	122	5	3f0c2486ea357d10dad0b703cf75cc29bdd5b5cf
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D122\|Adult / Lineage, Cell type, age group and donor	PLXND1 RGL1 LPAR6 TLR1 FKBP5	9.42e-05	166	122	5	be284e2e596390f05305c7bcfc316f87b963fc0b
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(NPW+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMPRSS6 ADH6 CRYBA2 TENM1 CPNE4	9.96e-05	168	122	5	4e1b522c7400c9d87f63c00e4e1dd07136095cd6
ToppCell	mild_COVID-19-HSPC\|mild_COVID-19 / disease group, cell group and cell class (v2)	CHMP4C CACNA1F OBSL1 NKAIN2 C1QTNF4	9.96e-05	168	122	5	90b33962adb77d8326dee403712118398b4d1315
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 SCRN1 THBD THBS2 COL1A2	1.02e-04	169	122	5	bb43abad2c049b7f4d307737347290e01b3339a3
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GRB10 FBN2 PAPPA CRYBG3 COL1A2	1.02e-04	169	122	5	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THBS2 CPNE4 CLSPN DCLK1 COL1A2	1.02e-04	169	122	5	335619507857383c3b0b507cdf05d786ed59e585
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 SCRN1 THBD THBS2 COL1A2	1.02e-04	169	122	5	5f18e3f40a5b1b167903f37516ec8181e889c7c5
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 SCRN1 THBD THBS2 COL1A2	1.02e-04	169	122	5	8bfa2d3bb541d02f55d7c95b8fd156c8403befca
ToppCell	mild_COVID-19-HSPC\|World / disease group, cell group and cell class (v2)	CHMP4C CACNA1F OBSL1 NKAIN2 C1QTNF4	1.05e-04	170	122	5	85c476e0bc496445e868a88849960598d97bdea2
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP24 THBS2 CRYGN PAPPA NOTCH2	1.08e-04	171	122	5	4ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CHMP4C LPCAT1 ADAMTS6 TLR1 DCLK2	1.11e-04	172	122	5	1aecc98a3eadabae0f1f328091a9733d916017ec
ToppCell	facs-Marrow-KLS-18m-Hematologic-Unknown_Progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHMP4C TMPRSS6 LMTK3 NCAN C1QTNF4	1.14e-04	173	122	5	295bfe1efa648173c2d5981025bc61c576baf53f
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OBSCN FBN2 PAPPA CRYBG3 COL1A2	1.17e-04	174	122	5	f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HK2 CD248 TMPRSS6 DMPK COL1A2	1.17e-04	174	122	5	68a6ed81e7e1f95b61f7ee20403980fa3a8db4d0
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CD248 TMPRSS6 SCRN1 IL6 DCLK1	1.17e-04	174	122	5	1d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CD248 THBS2 SERINC5 GNB3 COL1A2	1.24e-04	176	122	5	b4a23d8d1414434adeb237a96f28c825f1aebd77
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CD248 THBS2 SERINC5 GNB3 COL1A2	1.24e-04	176	122	5	66c9c6b59030f67e8d746a9c6930e50923f2ded1
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAMTA2 ALKBH1 UBE3D CRYGN DMPK	1.24e-04	176	122	5	8e89471f838ea81235256cc2470f1c12c9b75f8a
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages\|lymph-node_spleen / Manually curated celltypes from each tissue	TCN2 OBSL1 PLXND1 RGL1 THBD	1.27e-04	177	122	5	52c2ba74a8605260a2623e7d151286e504ac4d19
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLR2 UBA6 DMPK DCLK1 ALPK2	1.27e-04	177	122	5	14fb8d182775dfd0e49aa7e4e12543a85b3b8bd6
ToppCell	Dendritic_Cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	WAS GAL3ST2 FBN2 LPAR6 TLR1	1.31e-04	178	122	5	61ce3ec64c4cffceac08412e20c26e9c90ab8197
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SMOC1 HMCN2 ADAMTS6 SPOCK3 FBN3	1.31e-04	178	122	5	3c973aac16988e88f5677d3d695dd772ccfd6570
ToppCell	Posterior_cortex-Hematopoietic-MICROGLIA\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CACNA1F HK2 WAS DENND1C TLR2	1.34e-04	179	122	5	5122fc794509492afde4af8b1b76d51e3070ef05
ToppCell	TCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-1\|TCGA-Adrenal / Sample_Type by Project: Shred V9	RANBP2 CRYBA2 THBD SPOCK3 DCLK1	1.34e-04	179	122	5	431e1b29015ec817f778499106d24b19cfc825ae
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CD248 SMOC1 THBS2 DCLK1 COL1A2	1.38e-04	180	122	5	c2746092ef251e9d5910fe96461afdd0624a24c6
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CD248 SMOC1 THBS2 DCLK1 COL1A2	1.38e-04	180	122	5	32c6a3886428d82fb4355d987c6d2645f333447b
ToppCell	Neuroendocrine-neuroendo-1\|World / Class top	DENND1C CRYBA2 CITED4 SPOCK3 DMPK	1.38e-04	180	122	5	50fdd182a083380899b5943cb5f55ffd77e2a7d4
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(NPW+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RIMKLA TMPRSS6 SMOC1 CRYBA2 CPNE4	1.41e-04	181	122	5	2392af8c7f040c23a7d416c2e37419954970c8f4
ToppCell	Pericytes-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	CD248 THBS2 HMCN2 C1QTNF4 COL1A2	1.41e-04	181	122	5	35c470988a93381eefa300831aabb813fa1b90bd
Drug	PEMs	CHIA CD248 THBD TLR2 IL6	1.87e-06	39	120	5	CID003082702
Disease	type 1 diabetes mellitus (is_marker_for)	CHI3L1 THBD TLR2 IL6 HDAC2	1.06e-05	72	118	5	DOID:9744 (is_marker_for)
Disease	dyslexia (implicated_via_orthology)	DCLK2 DCLK1	1.59e-05	2	118	2	DOID:4428 (implicated_via_orthology)
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR1 TLR2 IL6	4.07e-05	17	118	3	DOID:8677 (biomarker_via_orthology)
Disease	connective tissue disease (implicated_via_orthology)	FBN2 FBN3	4.74e-05	3	118	2	DOID:65 (implicated_via_orthology)
Disease	Squamous cell carcinoma	UBA7 EP300 IL6 NOTCH2 HDAC2	1.45e-04	124	118	5	C0007137
Disease	coronary artery disease (is_marker_for)	CHI3L1 THBD PAPPA IL6	1.53e-04	67	118	4	DOID:3393 (is_marker_for)
Disease	small cell carcinoma (is_marker_for)	CHI3L1 IL6	2.35e-04	6	118	2	DOID:0050685 (is_marker_for)
Disease	Drug toxicity	TCN2 THBD TLR1 TLR2	3.66e-04	84	118	4	C0013221
Disease	Adverse reaction to drug	TCN2 THBD TLR1 TLR2	3.66e-04	84	118	4	C0041755
Disease	pulmonary tuberculosis (is_marker_for)	TLR1 TLR2 IL6	4.04e-04	36	118	3	DOID:2957 (is_marker_for)
Disease	multiple myeloma (is_marker_for)	RANBP2 CHI3L1 NOTCH2	4.04e-04	36	118	3	DOID:9538 (is_marker_for)
Disease	asthma (is_implicated_in)	CHIA CHI3L1 THBD TLR1 TLR2	4.32e-04	157	118	5	DOID:2841 (is_implicated_in)
Disease	gestational diabetes (is_implicated_in)	CDKAL1 IL6	4.37e-04	8	118	2	DOID:11714 (is_implicated_in)
Disease	Leprosy	TLR1 TLR2	4.37e-04	8	118	2	C0023343
Disease	leprosy (is_implicated_in)	TLR1 TLR2	4.37e-04	8	118	2	DOID:1024 (is_implicated_in)
Disease	insulin sensitivity measurement, insulin response measurement	GRB10 CDKAL1	4.37e-04	8	118	2	EFO_0004471, EFO_0008473
Disease	juvenile rheumatoid arthritis (is_marker_for)	THBD IL6	4.37e-04	8	118	2	DOID:676 (is_marker_for)
Disease	choroidal melanoma	RAB11FIP2 MIER3	5.60e-04	9	118	2	EFO_0009093
Disease	familial Mediterranean fever (is_marker_for)	THBD IL6	5.60e-04	9	118	2	DOID:2987 (is_marker_for)
Disease	insulin response measurement	GRB10 CDKAL1	5.60e-04	9	118	2	EFO_0008473
Disease	Myocardial Infarction	MIA3 THBD PAPPA IL6	5.84e-04	95	118	4	C0027051
Disease	ankylosing spondylitis (is_marker_for)	THBD IL6	6.99e-04	10	118	2	DOID:7147 (is_marker_for)
Disease	Alcoholic Intoxication, Chronic	NKAIN2 ADH6 EP300 FKBP5 IL6 HDAC2	7.48e-04	268	118	6	C0001973
Disease	severe acute respiratory syndrome (is_marker_for)	THBD TLR2 IL6	8.89e-04	47	118	3	DOID:2945 (is_marker_for)
Disease	birth weight, pelvic organ prolapse	FBN2 UBE3D NCAN	1.00e-03	49	118	3	EFO_0004344, EFO_0004710
Disease	acute myeloid leukemia (is_marker_for)	TCN2 CHI3L1 IL6	1.00e-03	49	118	3	DOID:9119 (is_marker_for)
Disease	Night blindness, congenital stationary, type 1	CACNA1F GNB3	1.02e-03	12	118	2	C3501847
Disease	Night Blindness, Congenital Stationary, Type 1A	CACNA1F GNB3	1.02e-03	12	118	2	C3495587
Disease	NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2B (disorder)	CACNA1F GNB3	1.02e-03	12	118	2	C1864877
Disease	NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B	CACNA1F GNB3	1.02e-03	12	118	2	C1850362
Disease	intracranial aneurysm (is_implicated_in)	IL6 COL1A2	1.02e-03	12	118	2	DOID:10941 (is_implicated_in)
Disease	X-Linked Csnb	CACNA1F GNB3	1.02e-03	12	118	2	C3711543
Disease	NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A	CACNA1F GNB3	1.02e-03	12	118	2	C1848172
Disease	aspartate aminotransferase measurement	WWC3 OBSCN ATP8B1 AGBL4 RGL1 HARS2 HMCN2 ADAMTS6 ENTPD5 C1QTNF4 ALPK2	1.02e-03	904	118	11	EFO_0004736
Disease	lung disease (implicated_via_orthology)	TLR2 IL6	1.20e-03	13	118	2	DOID:850 (implicated_via_orthology)
Disease	Cone-rod synaptic disorder, congenital nonprogressive	CACNA1F GNB3	1.20e-03	13	118	2	C4041558
Disease	hypertension (is_marker_for)	THBD PAPPA IL6	1.26e-03	53	118	3	DOID:10763 (is_marker_for)
Disease	Kuhnt-Junius degeneration (is_marker_for)	TLR2 IL6	1.40e-03	14	118	2	DOID:10873 (is_marker_for)
Disease	melanoma	RAB11FIP2 CDKAL1 EYS HMCN2	1.67e-03	126	118	4	EFO_0000756
Disease	asthma (is_marker_for)	CHIA CHI3L1 IL6 HDAC2	1.67e-03	126	118	4	DOID:2841 (is_marker_for)
Disease	cholesteatoma of middle ear (is_marker_for)	TLR2 IL6	1.83e-03	16	118	2	DOID:10964 (is_marker_for)
Disease	depressive disorder (is_implicated_in)	GNB3 IL6	2.07e-03	17	118	2	DOID:1596 (is_implicated_in)
Disease	major depressive disorder (is_implicated_in)	FKBP5 IL6	2.07e-03	17	118	2	DOID:1470 (is_implicated_in)
Disease	Night blindness, congenital stationary	CACNA1F GNB3	2.07e-03	17	118	2	C0339535
Disease	dermatomyositis (is_marker_for)	THBD TLR2	2.07e-03	17	118	2	DOID:10223 (is_marker_for)
Disease	Colorectal Carcinoma	CD248 TCN2 OBSCN FBN2 TLR2 TENM1 DNAH8 EP300 DCLK1	2.08e-03	702	118	9	C0009402
Disease	pulmonary hypertension (is_marker_for)	THBD IL6 HDAC2	2.17e-03	64	118	3	DOID:6432 (is_marker_for)
Disease	type 2 diabetes mellitus (is_marker_for)	CHI3L1 THBD PAPPA IL6	2.21e-03	136	118	4	DOID:9352 (is_marker_for)
Disease	Coronary Arteriosclerosis	MIA3 PAPPA GNB3	2.27e-03	65	118	3	C0010054
Disease	Coronary Artery Disease	MIA3 PAPPA GNB3	2.27e-03	65	118	3	C1956346
Disease	Oral Submucous Fibrosis	IL6 COL1A2	2.33e-03	18	118	2	C0029172
Disease	sinusitis (is_marker_for)	CHIA TLR2	2.33e-03	18	118	2	DOID:0050127 (is_marker_for)
Disease	gestational age	PNMA6F EYS SPOCK3 VWA3B	2.33e-03	138	118	4	EFO_0005112
Disease	breast carcinoma	LPCAT1 ARHGAP24 CD248 MIER3 CDKAL1 RTKN2 CITED4 FBN2 TLR1 NOTCH2 COL1A2	2.62e-03	1019	118	11	EFO_0000305
Disease	Schizophrenia	CACNA1F GRB10 CHI3L1 RTKN2 NCAN TLR2 GNB3 IL6 DCLK1 HDAC2	2.92e-03	883	118	10	C0036341
Disease	Bipolar Disorder	NCAN TLR2 GNB3 DNAH8 FKBP5 IL6 DCLK1	3.12e-03	477	118	7	C0005586
Disease	prostate carcinoma (is_marker_for)	CHI3L1 HDAC2	3.80e-03	23	118	2	DOID:10286 (is_marker_for)
Disease	idiopathic pulmonary fibrosis (is_marker_for)	THBD EP300	3.80e-03	23	118	2	DOID:0050156 (is_marker_for)
Disease	response to clopidogrel, cardiovascular event measurement	DYSF R3HCC1L	3.80e-03	23	118	2	EFO_0006919, GO_1903493
Disease	Malignant neoplasm of breast	TMPRSS6 PPP1R12B OBSCN ATP8B1 DYSF RGL1 TENM1 CLSPN EP300 IL6 NOTCH2	3.90e-03	1074	118	11	C0006142

Protein segments in the cluster

Peptide	Gene	Start	Entry
DCFSVGSNVDIDFSG	VDAC3	121	Q9Y277
FAFEEIDGVDLCFFG	EP300	1361	Q09472
PFYNGGNCVTDEFEE	BAG5	111	Q9UL15
GFQGECIDFTEETSD	CRYBG3	2676	Q68DQ2
AGIDFCFEAIGNLDV	ADH6	261	P28332
ACGFEDFRAEAGILN	ALKBH1	206	Q13686
CFEAGDQGTCFDTID	ALPK2	806	Q86TB3
FVTCNDINEDDFGDF	AFTPH	421	Q6ULP2
DDFGEFGDINAVSCQ	AFTPH	476	Q6ULP2
CQFGFEGACPALQDE	CD248	156	Q9HCU0
GGEDEDRFDNCVTFT	GVINP1	1106	Q7Z2Y8
LAFDTEFVNIGGDFD	C1QTNF4	201	Q9BXJ3
AIDLDDFTGTFCNQG	CHIA	361	Q9BZP6
CFFIQDDDSGEELKG	CAMTA2	441	O94983
FEGDNFQGCKFDLVD	CRYBA2	111	P53672
QGFAGDGFFCEDRDE	FBN3	1351	Q75N90
FSDQFEQEITGCGAS	DENND1C	401	Q8IV53
SEAFSQRVGFGDDFD	CHMP4C	146	Q96CF2
LATFDGFIECEEPNN	ATP8B1	256	O43520
GDGSTCDAIEGFFND	ADAMTS6	711	Q9UKP5
GSPDGVFDQTCVDFE	R3HCC1L	271	Q7Z5L2
FETGLSEGNDECFQD	RAD51AP2	931	Q09MP3
ETNPVVFFDVCADGE	RANBP2	3061	P49792
FRIFCGDLGNEVNDD	RBM42	381	Q9BTD8
FFETRCKADNAEEGG	NTF4	136	P34130
EGGESAEFTCFSEDL	RGL1	221	Q9NZL6
DGSFVVCEANANVGF	RIMKLA	266	Q8IXN7
GGEFVCDAGDDSAFF	OBSL1	1056	O75147
ESDFGPGEEFTCGSN	CACNA1F	1401	O60840
FDCRDVAFTVGEGED	FKBP5	181	Q13451
DFTFECNCLPGFEGS	NOTCH2	241	Q04721
NGFCADFSPENSDAG	LPCAT1	511	Q8NF37
EVCDNLENFTSGSPF	ENTPD5	361	O75356
CLDEVLNAAFDGGFT	LONP2	826	Q86WA8
NSFICECDEQFSGPF	EYS	276	Q5T1H1
FSSCQGQEDCAFDGV	ENTPD8	326	Q5MY95
GFELDSQGAFCVDRD	HMCN2	4616	Q8NDA2
DVGFKEFENPEGEDC	LMTK3	66	Q96Q04
QDFFGDDDIFIACGP	DCLK1	246	O15075
LQDFFGDDDVFIACG	DCLK2	256	Q8N568
AFGDNGCLDDFRTEF	HK2	711	P52789
LDDFQGSFCGQDLRF	CHI3L1	356	P36222
VFALFDCDGNGELSN	MICU1	416	Q9BPX6
ACQPISFSGFGAEDD	POLD2	446	P49005
FSGREQPGCVEESFE	PNMA6F	256	A0A0J9YX94
FQGAALECSFGLEEI	PLXND1	781	Q9Y4D7
FSDGDCVDLNPEFGI	DNAH8	1931	Q96JB1
GENDVIGCFANFETE	HNRNPUL2	356	Q1KMD3
CITEEEDSFDFIGGF	NKAIN2	171	Q5VXU1
ESDINAICFFPNGEA	GNB3	226	P16520
GNNASEACFENFPEA	LPAR6	161	P43657
VLDFVQDPCFAQGDG	PSMD13	41	Q9UNM6
SNGESDCFNLFETGF	MIER3	446	Q7Z3K6
FNFDGGECCDPEITN	PAPPA	466	Q13219
PEACGELSNGFFIQD	PRADC1	71	Q9BSG0
AREFEIDFAGTDSGC	EXOC8	471	Q8IYI6
LEVFGDCDNFQDRGF	CRYGN	21	Q8WXF5
PDFEGATDTCNFDLV	DMPK	356	Q09013
EGVADFFEVFCQQVG	PTPRO	746	Q16827
GGGCEEEFVSFANQL	OTUD3	46	Q5T2D3
FADRGFFGCETPDDK	OBSCN	2051	Q5VST9
FILACQDEETGGFAD	RABGGTB	266	P53611
TTCPEQDFFGGNFED	ARHGAP24	576	Q8N264
DFGFDPNAQCEEGYV	GAL3ST2	196	Q9H3Q3
GADQEFFVDIGPVCF	COL1A2	1351	P08123
DIICGFPGETDQDFQ	CDKAL1	361	Q5VV42
DFAINFNEDNPECAG	CPNE4	376	Q96A23
FDACFESGNLGRVDQ	AGBL4	46	Q5VU57
GGAVFEDEQEEFVCN	GJD3	41	Q8N144
NNAFSDSFVDSCPEG	CCDC32	36	Q9BV29
VFSQGGQVDCGEFQD	SPINK6	21	Q6UWN8
PCEDDGQTFFSLDDG	GRB10	546	Q13322
FEGDDGFCVFESNAI	EEF1G	61	P26641
VIGSFECNCNEGFEP	FBN2	2231	P35556
NVGEDCPVFDGLFEF	HDAC2	96	Q92769
NVEAFEGLSDFCNTF	DYSF	1511	O75923
AEKDGCFQSGFNEET	IL6	96	P05231
CFADFECGNDVELSF	HNRNPUL1	331	Q9BUJ2
CFENVTIFNEAGPDF	RTKN2	156	Q8IZC4
GFICTDIDECENGGF	THBD	436	P07204
EFCQCDFDIAGQFDP	HARS2	171	P49590
QEVEDPFGFALEAGC	SUPT20HL1	331	Q3ZLR7
FDCGNDIFEEGDEPK	SLC9C1	891	Q4G0N8
TPNECSDDFGEFQSE	SYNRG	1016	Q9UMZ2
PTDETDFVCFDGGRD	MIA3	116	Q5JRA6
ENQPDNFFAGGEDCV	NCAN	1171	O14594
FEVVAGTGDQCLPFD	TENM1	1276	Q9UKZ4
VFTPDGNCNREAFDV	WDR45	336	Q9Y484
PDVETFQNTVGDCFG	SLC26A3	331	P40879
FGCSGADDREAQQQF	PROB1	121	E7EW31
GEGEFNFSEVFSPVE	SCRN1	216	Q12765
SCEFGAAFESAGEEE	SLX4	1721	Q8IY92
AGDNPFQCTCELGEF	TLR1	521	Q15399
QQCLLGSAFSEDDGD	TCN2	81	P20062
DQGFVGLIFSCFIED	BRCC3	146	P46736
FLGQSEFDCFSDLGS	CITED4	161	Q96RK1
TLFLGAGDFQFCLED	CLSPN	851	Q9HAW4
FITVDAVGCFEGDEE	CIZ1	731	Q9ULV3
NGVFLASELEDFECF	SPG11	946	Q96JI7
TFFPEDEQLFSSNGC	TOR2A	296	Q5JU69
FCDFGDEFEVLDTTG	UBA6	196	A0AVT1
EAVFVPECGEDGSFT	SMOC1	111	Q9H4F8
FQGDEGACPTRDFVV	ZCCHC3	171	Q9NUD5
GQLFCDFGEDFTVQD	UBA7	156	P41226
NAGFGDDLNCIFNDD	POLR2A	1236	P24928
PQENDCFIGDSFFLV	UBE3D	156	Q7Z6J8
NPGGVVQDFIFFCDA	TNPO2	831	O14787
CFCFSPGGEDTEEQQ	SERINC5	356	Q86VE9
TFAGDDCQAGLNFAD	WAS	116	P42768
DEGELCFGRQNDPFT	RAB11FIP2	291	Q7L804
DFGEDGTDGLLDSFC	SAFB2	146	Q14151
DGFDTGEFATQTCLQ	PKHD1L1	2411	Q86WI1
GVADCAIDFEISGDF	SPOCK3	376	Q9BQ16
SAFVVDEGCLSFTDG	TMEM174	191	Q8WUU8
ARGAGCSSEQFEEAF	ZZEF1	106	O43149
GTFACTECGQDFAQE	ZNF576	141	Q9H609
GDACSVDIDGDDVFN	THBS2	796	P35442
CVEFPAFSTKDGDNV	VWA3B	301	Q502W6
ELEFDDCTLNGVGNF	TLR2	281	O60603
GEEQVNFCESSNDFG	ZBTB22	371	O15209
QFCDAGSQTDIIGEF	WWC3	206	Q9ULE0
QEGVPCGTFTFQCED	TMPRSS6	526	Q8IU80
FEDGAVFLAACSSGD	PPP1R12B	56	O60237