Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	SAGA complex	SUPT20HL1 SUPT20HL2 TAF6	4.70e-05	25	59	3	GO:0000124
GeneOntologyCellularComponent	SAGA-type complex	SUPT20HL1 SUPT20HL2 TAF6	1.82e-04	39	59	3	GO:0070461
Domain	Cornifin	SPRR1A SPRR3	4.90e-05	4	54	2	IPR003302
Domain	SPRR/LCE	SPRR1A SPRR3 LCE3E	7.11e-05	28	54	3	IPR026075
Domain	DUF4599	SPATA31D4 SPATA31D3	5.32e-04	12	54	2	PF15371
Domain	DUF4599	SPATA31D4 SPATA31D3	5.32e-04	12	54	2	IPR027970
Domain	C2	CEP120 PCLO RGS3 RPH3A	5.57e-04	131	54	4	PF00168
Domain	C2	CEP120 PCLO RGS3 RPH3A	6.59e-04	137	54	4	SM00239
Domain	Pept_M10A_Zn_BS	MMP1 MMP8	8.41e-04	15	54	2	IPR021158
Domain	-	CEP120 PCLO RGS3 RPH3A	8.80e-04	148	54	4	2.60.40.150
Domain	Hemopexin_CS	MMP1 MMP8	1.09e-03	17	54	2	IPR018486
Domain	Pept_M10A_stromelysin-type	MMP1 MMP8	1.22e-03	18	54	2	IPR016293
Domain	C2_dom	CEP120 PCLO RGS3 RPH3A	1.29e-03	164	54	4	IPR000008
Domain	Synaptotagmin	PCLO RPH3A	1.51e-03	20	54	2	IPR001565
Domain	PG_binding_1	MMP1 MMP8	1.51e-03	20	54	2	PF01471
Domain	Peptidoglycan-bd-like	MMP1 MMP8	1.51e-03	20	54	2	IPR002477
Domain	Hemopexin-like_dom	MMP1 MMP8	2.00e-03	23	54	2	IPR000585
Domain	Hemopexin-like_repeat	MMP1 MMP8	2.00e-03	23	54	2	IPR018487
Domain	M10A_MMP	MMP1 MMP8	2.00e-03	23	54	2	IPR033739
Domain	Hemopexin	MMP1 MMP8	2.00e-03	23	54	2	PF00045
Domain	HEMOPEXIN	MMP1 MMP8	2.00e-03	23	54	2	PS00024
Domain	-	MMP1 MMP8	2.00e-03	23	54	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP1 MMP8	2.00e-03	23	54	2	PS51642
Domain	HX	MMP1 MMP8	2.00e-03	23	54	2	SM00120
Domain	Pept_M10A	MMP1 MMP8	2.00e-03	23	54	2	IPR021190
Domain	Peptidase_M10	MMP1 MMP8	2.17e-03	24	54	2	PF00413
Domain	ZnMc	MMP1 MMP8	3.17e-03	29	54	2	SM00235
Domain	Peptidase_Metallo	MMP1 MMP8	3.17e-03	29	54	2	IPR006026
Domain	CYSTEINE_SWITCH	MMP1 MMP8	6.26e-03	41	54	2	PS00546
Domain	Pept_M10_metallopeptidase	MMP1 MMP8	6.87e-03	43	54	2	IPR001818
Domain	C2	PCLO RGS3 RPH3A	8.04e-03	142	54	3	PS50004
Pubmed	Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues.	IVL SPRR1A SPRR3	1.01e-06	12	59	3	9888996
Pubmed	Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts.	SPRR1A SPRR3	2.83e-06	2	59	2	8018055
Pubmed	Matrix metalloproteinase-1 (MMP-1) and (MMP-8) gene polymorphisms promote increase and remodeling of the collagen III and V in posterior tibial tendinopathy.	MMP1 MMP8	2.83e-06	2	59	2	29532899
Pubmed	Serum Matrix Metalloproteinase-8 and Myeloperoxidase Predict Survival after Resection of Colorectal Liver Metastases.	MPO MMP8	2.83e-06	2	59	2	34571507
Pubmed	Matrix metalloproteinases gene polymorphism haplotype is a risk factor to implant loss: A case-control study.	MMP1 MMP8	2.83e-06	2	59	2	30328228
Pubmed	Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein.	PER2 SIK3	2.83e-06	2	59	2	29227248
Pubmed	Prevotella intermedia upregulates MMP-1 and MMP-8 expression in human periodontal ligament cells.	MMP1 MMP8	2.83e-06	2	59	2	19708869
Pubmed	Opposing effects of emphysema, hay fever, and select genetic variants on lung cancer risk.	MPO MMP1	2.83e-06	2	59	2	15718477
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ZNF462 GPR158 KSR2 SIK3 CDC42BPB AGRN RPH3A RAB3C GOLGA3 LDB2	4.65e-06	963	59	10	28671696
Pubmed	Differentially expressed late constituents of the epidermal cornified envelope.	IVL SPRR1A LCE3E	8.02e-06	23	59	3	11698679
Pubmed	Causal Effect of MMP-1 (Matrix Metalloproteinase-1), MMP-8, and MMP-12 Levels on Ischemic Stroke: A Mendelian Randomization Study.	MMP1 MMP8	8.48e-06	3	59	2	33902302
Pubmed	Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro.	IVL SPRR3	8.48e-06	3	59	2	11443109
Pubmed	Salivary Matrix Metalloproteinase-8 and -9 and Myeloperoxidase in Relation to Coronary Heart and Periodontal Diseases: A Subgroup Report from the PAROKRANK Study (Periodontitis and Its Relation to Coronary Artery Disease).	MPO MMP8	8.48e-06	3	59	2	26132583
Pubmed	Polymorphism +17 C/G in matrix metalloprotease MMP8 decreases lung cancer risk.	MMP1 MMP8	8.48e-06	3	59	2	19094243
Pubmed	The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation.	SPRR1A SPRR3	8.48e-06	3	59	2	7829876
Pubmed	Plasma MMP1 and MMP8 expression in breast cancer: protective role of MMP8 against lymph node metastasis.	MMP1 MMP8	8.48e-06	3	59	2	18366705
Pubmed	Relationship between plasma matrix metalloproteinase levels, pulmonary function, bronchodilator response, and emphysema severity.	MMP1 MMP8	8.48e-06	3	59	2	27313452
Pubmed	The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5.	SUPT20HL1 SUPT20HL2	8.48e-06	3	59	2	24220028
Pubmed	Collagenase expression and activity in the stromal cells from giant cell tumour of bone.	MMP1 MMP8	8.48e-06	3	59	2	19442604
Pubmed	[Matrix metalloproteinase-1, -8, -9 and the risk of cardiovascular complications in patients with CHD before and after myocardial revascularization].	MMP1 MMP8	8.48e-06	3	59	2	29215835
Pubmed	Salivary levels of MPO, MMP-8 and TIMP-1 are associated with gingival inflammation response patterns during experimental gingivitis.	MPO MMP8	8.48e-06	3	59	2	30626536
Pubmed	Serum matrix metalloproteinase-8, tissue inhibitor of metalloproteinase and myeloperoxidase in ischemic stroke.	MPO MMP8	8.48e-06	3	59	2	29453088
Pubmed	The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.	SUPT20HL1 SUPT20HL2 TAF6	1.47e-05	28	59	3	19114550
Pubmed	Gingival crevicular fluid levels of MMP-8, MMP-9, TIMP-2, and MPO decrease after periodontal therapy.	MPO MMP8	1.69e-05	4	59	2	19995403
Pubmed	Expression and Significance of Metalloproteinase and Collagen in Vaginal Wall Tissues of Patients with Pelvic Organ Prolapse.	MMP1 MMP8	1.69e-05	4	59	2	29263043
Pubmed	[The system of matrix metalloproteinases and their role in patients with pulmonary tuberculosis].	MMP1 MMP8	1.69e-05	4	59	2	27797337
Pubmed	Distribution of matrix metalloproteinases MMP-1, MMP-2, MMP-8 and tissue inhibitor of matrix metalloproteinases-2 in nasal polyposis and chronic rhinosinusitis.	MMP1 MMP8	1.69e-05	4	59	2	21432777
Pubmed	A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.	SUPT20HL1 SUPT20HL2 TAF6	1.82e-05	30	59	3	18206972
Pubmed	Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators.	IVL MMP8 LCE3E	2.02e-05	31	59	3	20930145
Pubmed	Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.	GPR158 PROX2 AUTS2 ABCC6 RAB3C	2.27e-05	199	59	5	23382691
Pubmed	Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.	SUPT20HL1 SUPT20HL2 TAF6	2.44e-05	33	59	3	11564863
Pubmed	Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain.	MMP1 MMP8	2.82e-05	5	59	2	9688535
Pubmed	S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes.	IVL SPRR1A	2.82e-05	5	59	2	9115270
Pubmed	Matrix metalloproteinases: structures, evolution, and diversification.	MMP1 MMP8	2.82e-05	5	59	2	9737711
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	ZNF462 GPR158 AUTS2 SIK3 CDC42BPB	4.08e-05	225	59	5	12168954
Pubmed	Piccolo, a presynaptic zinc finger protein structurally related to bassoon.	PCLO RPH3A	4.23e-05	6	59	2	10707984
Pubmed	Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype.	SPRR1A SPRR3	4.23e-05	6	59	2	27304082
Pubmed	Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes.	IVL SPRR1A	4.23e-05	6	59	2	10441742
Pubmed	Matrix metalloproteinase polymorphisms and bladder cancer risk.	MMP1 MMP8	4.23e-05	6	59	2	17178858
Pubmed	Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan.	MMP1 MMP8	4.23e-05	6	59	2	7998967
Pubmed	Matrix metalloproteinase polymorphisms are associated with bladder cancer invasiveness.	MMP1 MMP8	4.23e-05	6	59	2	17473191
Pubmed	ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors.	MMP1 MMP8	4.23e-05	6	59	2	12054629
Pubmed	Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3.	MMP1 MMP8	5.91e-05	7	59	2	8921407
Pubmed	Expression of extracellular matrix metalloproteinase inducer and matrix metalloproteinases during mouse embryonic development.	MMP1 MMP8	5.91e-05	7	59	2	17307908
Pubmed	Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction.	RPH3A RAB3C	5.91e-05	7	59	2	11359932
Pubmed	Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain.	MMP1 MMP8	5.91e-05	7	59	2	8216228
Pubmed	Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP).	MMP1 MMP8	5.91e-05	7	59	2	10922468
Pubmed	Matrix metalloproteinases cleave tissue factor pathway inhibitor. Effects on coagulation.	MMP1 MMP8	5.91e-05	7	59	2	10859319
Pubmed	Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation.	MMP1 MMP8	5.91e-05	7	59	2	11113146
Pubmed	Mono-ubiquitination of Rabphilin 3A by UBE3A serves a non-degradative function.	RPH3A RAB3C	5.91e-05	7	59	2	33542309
Pubmed	Matrix remodeling by MMPs during wound repair.	MMP1 MMP8	5.91e-05	7	59	2	25770908
Pubmed	Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes.	IVL SPRR1A	5.91e-05	7	59	2	10908733
Pubmed	Characterization of opticin digestion by proteases involved in osteoarthritis development.	MMP1 MMP8	7.87e-05	8	59	2	23845380
Pubmed	Crosstalk between Nodal/activin and MAPK p38 signaling is essential for anterior-posterior axis specification.	SUPT20HL1 SUPT20HL2	7.87e-05	8	59	2	21802298
Pubmed	Effect of combined genetic polymorphisms on lung cancer risk in northern Thai women.	MPO MMP1	7.87e-05	8	59	2	19963114
Pubmed	A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis.	MPO MMP8	7.87e-05	8	59	2	27579896
Pubmed	Mouse Sprr locus: a tandem array of coordinately regulated genes.	SPRR1A SPRR3	7.87e-05	8	59	2	12584609
Pubmed	Long-range comparison of human and mouse Sprr loci to identify conserved noncoding sequences involved in coordinate regulation.	SPRR1A SPRR3	7.87e-05	8	59	2	15574822
Pubmed	Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function.	SPRR1A SPRR3	1.01e-04	9	59	2	11279051
Pubmed	Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites.	MMP1 MMP8	1.01e-04	9	59	2	10986281
Pubmed	Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins.	SPRR1A SPRR3	1.26e-04	10	59	2	8325635
Pubmed	Loss of nidogen-1 and -2 results in syndactyly and changes in limb development.	BMP7 AGRN	1.54e-04	11	59	2	17023412
Pubmed	Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.	SUPT20HL1 SUPT20HL2	1.54e-04	11	59	2	24051374
Pubmed	The Vertebrate Genome Annotation browser 10 years on.	CFAP47 PCLO PMIS2 CDKL3	1.73e-04	163	59	4	24316575
Pubmed	Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo.	MMP1 MMP8	1.85e-04	12	59	2	12149192
Pubmed	Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.	SPRR1A SPRR3	1.85e-04	12	59	2	18643845
Pubmed	Fate and plasticity of the epidermis in response to congenital activation of BRAF.	IVL LCE3E	2.18e-04	13	59	2	25202828
Pubmed	Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope.	IVL SPRR3	2.18e-04	13	59	2	8999895
Pubmed	Appropriate Bmp7 levels are required for the differentiation of midline guidepost cells involved in corpus callosum formation.	BMP7 LDB2	2.18e-04	13	59	2	21485009
Pubmed	Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.	CDC42BPB RPH3A	2.54e-04	14	59	2	28263302
Pubmed	Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.	MMP1 MMP8	2.54e-04	14	59	2	16236725
Pubmed	WNT signals are required for the initiation of hair follicle development.	IVL BMP7	2.93e-04	15	59	2	12015971
Pubmed	Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.	CEP120 KSR2 PCDHA12 SIK3	3.30e-04	193	59	4	22589738
Pubmed	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	MPO BMP7 PPARGC1B PCLO	3.30e-04	193	59	4	20677014
Pubmed	Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families.	MMP1 MMP8	3.34e-04	16	59	2	20484597
Pubmed	p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis.	IVL LCE3E	3.34e-04	16	59	2	21930775
Pubmed	Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor.	MMP1 MMP8	3.34e-04	16	59	2	37701782
Pubmed	beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin.	IVL BMP7	3.79e-04	17	59	2	11371349
Pubmed	LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem.	BMP7 LDB2	4.75e-04	19	59	2	11165475
Pubmed	Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration.	IVL SPRR1A	5.82e-04	21	59	2	24198274
Pubmed	Bcl11b/Ctip2 is required for development of lingual papillae in mice.	IVL SPRR1A	5.82e-04	21	59	2	27287879
Pubmed	Sox2 modulates the function of two distinct cell lineages in mouse skin.	PCLO RAB3C	5.82e-04	21	59	2	23948231
Pubmed	Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.	IVL SPRR1A	5.82e-04	21	59	2	19601998
Pubmed	Cripto is required for mesoderm and endoderm cell allocation during mouse gastrulation.	SUPT20HL1 SUPT20HL2	5.82e-04	21	59	2	23747598
Pubmed	Supt20 is required for development of the axial skeleton.	SUPT20HL1 SUPT20HL2	5.82e-04	21	59	2	27894818
Pubmed	Functional interactions between matrix metalloproteinases and glycosaminoglycans.	MMP1 MMP8	6.39e-04	22	59	2	23421805
Pubmed	p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.	SUPT20HL1 SUPT20HL2	6.39e-04	22	59	2	16751104
Pubmed	BMP signaling in the development of the mouse esophagus and forestomach.	IVL BMP7	6.39e-04	22	59	2	21068065
Pubmed	Matrix metalloproteinases.	MMP1 MMP8	6.39e-04	22	59	2	10419448
Pubmed	Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds.	FAM90A22 FAM90A23	7.00e-04	23	59	2	18602769
Pubmed	Transcription Factor MafB Coordinates Epidermal Keratinocyte Differentiation.	IVL SPRR1A	7.62e-04	24	59	2	27208706
Pubmed	Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18.	IVL LCE3E	8.28e-04	25	59	2	23132931
Pubmed	Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development.	IVL SPRR1A	8.28e-04	25	59	2	31410202
Pubmed	Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition.	IVL LCE3E	8.28e-04	25	59	2	23906066
Pubmed	Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events.	FAM90A22 FAM90A23	8.28e-04	25	59	2	17684299
Pubmed	Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.	RPH3A RAB3C	8.96e-04	26	59	2	17124501
Pubmed	Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation.	IVL BMP7	8.96e-04	26	59	2	12805214
Pubmed	Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.	MPO MMP1 MMP8	1.00e-03	115	59	3	20485444
Pubmed	Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling.	IVL BMP7 SPRR1A	1.05e-03	117	59	3	22682244
Pubmed	Global analysis of gene expression in the developing brain of Gtf2ird1 knockout mice.	AUTS2 TAF6	1.12e-03	29	59	2	21909369
Cytoband	9q21.32	SPATA31D4 SPATA31D3	2.74e-04	19	59	2	9q21.32
Cytoband	Xp22.11	SUPT20HL1 SUPT20HL2	3.36e-04	21	59	2	Xp22.11
Cytoband	1q21-q22	SPRR1A SPRR3	4.04e-04	23	59	2	1q21-q22
Cytoband	11q22.3	MMP1 MMP8	1.48e-03	44	59	2	11q22.3
Cytoband	Ensembl 112 genes in cytogenetic band chr1q21	IVL SPRR1A SPRR3 LCE3E	1.84e-03	404	59	4	chr1q21
GeneFamily	Small proline rich proteins	SPRR1A SPRR3	1.98e-04	11	35	2	1353
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP1 MMP8	9.78e-04	24	35	2	891
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PCLO RGS3	2.20e-03	36	35	2	823
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CFAP47 PRMT8 PCLO KSR2 ABCC6	4.35e-06	189	57	5	7659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Nxph2_Wls\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TBATA CMYA5 SSTR4 LDB2	2.33e-05	130	57	4	05d5a73acf1d7f75a79876b1a06d27c74a89b8a4
ToppCell	Bronchial_Brush-Epithelial-Ciliated_2\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	IVL SPRR1A SPRR3 LCE3E	2.48e-05	132	57	4	780a391924f776dc6fbe44ddcf4ae0583a1e2157
ToppCell	Bronchial_Brush-Epithelial-Ciliated_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	IVL SPRR1A SPRR3 LCE3E	2.71e-05	135	57	4	366a417f9ef7c0d86e9f262d97bf788f478315ee
ToppCell	10x5'-blood-Lymphocytic_T_CD4/8-lo-Tgd_CRTAM\|blood / Manually curated celltypes from each tissue	DUSP5 AUTS2 TSEN54 RGS3	2.79e-05	136	57	4	f024015bf60e64b8657e410e24995a1edec85196
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	CFAP47 PRMT8 PCLO PLXNB1	4.76e-05	156	57	4	10d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell	facs-Lung-24m\|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IVL MPO SPRR1A ITGAE	5.51e-05	162	57	4	4e418bea07e35038b32a78a1e6632b6ec1208cdc
ToppCell	NS-moderate-d_0-4-Epithelial-Squamous\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IVL SPRR1A SPRR3 DUSP5	6.50e-05	169	57	4	4a5d023ffcf83312d29b1d215eb6b744ef1a0777
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IVL SPRR1A PCLO RAB3C	6.50e-05	169	57	4	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	healthy_donor-Myeloid-Monocytic-Developing_Neutrophil\|healthy_donor / Disease condition, Lineage, Cell class and subclass	MPO RECQL4 MMP8 PLXNB1	6.65e-05	170	57	4	cfd7f29805b7c51666b0eaf269c36c96b8765a1a
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IVL SPRR1A SPRR3 DUSP5	6.65e-05	170	57	4	13a225e32132e9717debb0d64d7c28ada974c3e6
ToppCell	TCGA-Head_and_Esophagus\|World / Sample_Type by Project: Shred V9	IVL SPRR1A SPRR3 LCE3E	6.96e-05	172	57	4	eb18aa179db1818f408c38e442ecfed8582d7dbc
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RECQL4 B3GNT3 SIK3 CDC42BPB	6.96e-05	172	57	4	8a6a2b4c6654bc976e60a02d0e7303a9071ed55f
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	IVL BMP7 SPRR1A SPRR3	7.44e-05	175	57	4	0cc215109d9915af47e4d0a120ce2e46910715fa
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR158 PCLO KSR2 GOLGA3	7.94e-05	178	57	4	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBATA PCLO RPH3A RAB3C	8.29e-05	180	57	4	f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Igfbp4-Inhibitory_Neuron.Gad1Gad2.Igfbp4.Adora1_(Striatum,_interneuron)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SPRR1A RECQL4 SSTR4	8.34e-05	66	57	3	d6b202d9f5bebaac23b34b689ad306549dec0593
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Igfbp4-Inhibitory_Neuron.Gad1Gad2.Igfbp4.Adora1_(Striatum,_interneuron)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SPRR1A RECQL4 SSTR4	8.34e-05	66	57	3	4a714cf035b22da103054098f85f9170c56e9e83
ToppCell	PSB-critical-LOC-Epithelial-Squamous\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IVL SPRR1A SPRR3 DUSP5	8.84e-05	183	57	4	2cf798a2371c61322484ea16fdfae0acfa94f102
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EECs\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFAP47 PCLO RAB3C PLXNB1	9.22e-05	185	57	4	d42f6722a6771752cd744146a09e2ead9b7252bc
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IVL SPRR1A SPRR3 DUSP5	9.22e-05	185	57	4	f3fbc3096f85397a959cee17c3c4fcf2d511f3d5
ToppCell	droplet-Lung-LUNG-1m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRR1A FAM178B CDKL3 PLXNB1	9.41e-05	186	57	4	e52cf44989c57c433bf82e9fa13b4643e88f3577
ToppCell	droplet-Lung-LUNG-1m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRR1A FAM178B CDKL3 PLXNB1	9.41e-05	186	57	4	4c0b59d845b79323e7a3287e7c4d249f5f322556
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	GPR158 PCLO KSR2 RAB3C	9.41e-05	186	57	4	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	wk_15-18-Endothelial-Lymph_endothelial-SCG3+_lymphatic_endothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PCLO DUSP5 B3GNT3 AGRN	1.00e-04	189	57	4	f0418851ad4042c4cd87c8729e4f0d43bdf8fccb
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	PRMT8 PCLO KSR2 PCDHA12	1.02e-04	190	57	4	6e92c78799f34b31d098854503c796edb0dc7f80
ToppCell	BL-critical-LOC-Epithelial-Squamous\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IVL SPRR1A SPRR3 DUSP5	1.04e-04	191	57	4	3f9b8c4fb72ae6f3167b187e6715c4dcb3159f98
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IVL SPRR1A SPRR3 DUSP5	1.04e-04	191	57	4	fbd8d337b4444fba8527a614e4a8bfb516ce0f66
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO GPR158 PCLO DUSP5	1.04e-04	191	57	4	3387b95a3f2445c672d407922fdce3a91eabaef8
ToppCell	(5)_Epithelial_cells-(5)_Epi_upper\|(5)_Epithelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	SPRR1A SPRR3 DUSP5 B3GNT3	1.06e-04	192	57	4	69b6b3ceaad6432c46d1bc2a00b8389069a8876e
ToppCell	NS-moderate-d_16-33-Epithelial-Squamous\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IVL SPRR1A SPRR3 DUSP5	1.06e-04	192	57	4	103496f428f59683ac3ae6147682c07c30663724
ToppCell	NS-critical-d_07-13-Epithelial-Squamous\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IVL SPRR1A SPRR3 DUSP5	1.11e-04	194	57	4	53a34843d529ef395deb27086f71f7049a087bab
ToppCell	NS-critical-d_0-4-Epithelial-Squamous\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IVL SPRR1A SPRR3 DUSP5	1.11e-04	194	57	4	614d0c25b56957c70f397abb169fd2a860eb1c06
ToppCell	10x5'-Liver-Lymphocytic_T_CD4/8-lo-Tgd_CRTAM\|Liver / Manually curated celltypes from each tissue	PER2 DUSP5 AUTS2 SIK3	1.13e-04	195	57	4	972b09697b7b66fb8a27dfc0c0b05a844121f055
ToppCell	NS-moderate-d_07-13\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1A SPRR3 DUSP5 LCE3E	1.13e-04	195	57	4	088209505a68519ec89f50f0576096da6966bf17
ToppCell	10x5'-Liver-Lymphocytic_T_CD4/8-lo\|Liver / Manually curated celltypes from each tissue	PER2 DUSP5 AUTS2 SIK3	1.13e-04	195	57	4	c29c4ae95a756e3ced0f0747bbfe343590e5b8ab
ToppCell	facs-Heart-RA-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT3 CDC42BPB RGS3 LDB2	1.13e-04	195	57	4	30c75761079fa1e1a3b84d23c88a222f459d5ce5
ToppCell	NS-critical-d_16-33-Epithelial-Squamous\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IVL SPRR1A SPRR3 DUSP5	1.15e-04	196	57	4	97e16d9833e4083d719ca7058d5fc9b11edb37e3
ToppCell	NS-critical-LOC-Epithelial-Squamous\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IVL SPRR1A SPRR3 DUSP5	1.15e-04	196	57	4	453c809494ceffa2a28af283c4b5a4924fcf160f
ToppCell	Basal_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	BMP7 MMP1 CMYA5 PLXNB1	1.15e-04	196	57	4	3b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IVL BMP7 SPRR1A SPRR3	1.17e-04	197	57	4	fb272c9c60ee3d980e528044dc567b4925a23da6
ToppCell	critical-Epithelial-Squamous\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	IVL SPRR1A SPRR3 DUSP5	1.17e-04	197	57	4	cfbdaada7169afb68455724ae87032ff311b2d89
ToppCell	NS-control-d_0-4-Epithelial-Squamous\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IVL SPRR1A SPRR3 DUSP5	1.17e-04	197	57	4	ab965a0ba87efd3329d24a1ec123985f46fc17c0
ToppCell	moderate-Epithelial-Squamous\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	IVL SPRR1A SPRR3 DUSP5	1.17e-04	197	57	4	ab3c90a5b643b45d0b83939c6304b11f567c5d78
ToppCell	critical-Epithelial-Squamous\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	IVL SPRR1A SPRR3 DUSP5	1.17e-04	197	57	4	eccc80d6ab79c46b10108de1cff3abeacfc105cd
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PRMT8 RECQL4 KSR2 PIERCE2	1.17e-04	197	57	4	861e8df9bd74dc5e17bafdc1fb3fef546753c73a
ToppCell	Basal_cells\|World / lung cells shred on cell class, cell subclass, sample id	BMP7 MMP1 CMYA5 PLXNB1	1.17e-04	197	57	4	24360b660000bdfb999d58fbf4e29585a97e1785
ToppCell	Bronchus_Control_(B.)\|World / Sample group, Lineage and Cell type	PER2 SPRR3 SIK3 CMYA5	1.17e-04	197	57	4	b6dff2ee108813e18657e2d8cf850e2423f8c8e9
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IVL BMP7 SPRR1A SPRR3	1.17e-04	197	57	4	61c0d78b29dc4ad8a84172cbfcdab03f31351d0e
ToppCell	moderate-Epithelial-Squamous\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	IVL SPRR1A SPRR3 DUSP5	1.17e-04	197	57	4	2e13881f917d4f62a5b3e968e41c57e43300d988
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IVL BMP7 SPRR1A SPRR3	1.17e-04	197	57	4	dcabea5c50c133c9a4e294e447462d0393174ea7
ToppCell	control-Epithelial-Squamous\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	IVL SPRR1A SPRR3 DUSP5	1.20e-04	198	57	4	6ba669ac1ed275ae309054941b1457e315766faa
ToppCell	NS-moderate-d_07-13-Epithelial-Squamous\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IVL SPRR1A SPRR3 DUSP5	1.20e-04	198	57	4	b7495369baba203490c067a58fc8456a778a12e4
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IVL BMP7 SPRR1A SPRR3	1.20e-04	198	57	4	e06d41a7254a09e037ec404be2d8c352d5cbd7f4
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GPR158 PCLO KSR2 RAB3C	1.20e-04	198	57	4	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	control-Epithelial-Squamous\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	IVL SPRR1A SPRR3 DUSP5	1.22e-04	199	57	4	e13dca7a055cdca53dd6c26c04b2a46d58b419b6
ToppCell	COVID-19-COVID-19_Mild-Myeloid-immature_Neutrophil\|COVID-19_Mild / Disease, condition lineage and cell class	MPO RECQL4 MMP8 PLXNB1	1.22e-04	199	57	4	e222b90caf45904d8f763574e7b6aac13333df92
ToppCell	distal-1-Epithelial-Differentiating_Basal\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	BMP7 SPRR1A SPRR3 B3GNT3	1.22e-04	199	57	4	fe7d6f70fe337b91b0ad63ea33e5a714d2df87bd
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	PCLO AUTS2 CHM RAB3C	1.24e-04	200	57	4	ac0e023dbb383bbc46c5cc525431778be8f7ef46
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF462 BMP7 RPH3A RAB3C	1.24e-04	200	57	4	e90155498397524b812c46f2412320230b445bb6
ToppCell	tumor_Lung-Endothelial_cells-Tumor_ECs\|Endothelial_cells / Location, Cell class and cell subclass	MMP1 AGRN RGS3 RAB3C	1.24e-04	200	57	4	9c1b30fa96565515a7160f439cadcd51482c41e9
Drug	METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID	MMP1 MMP8	5.32e-06	2	53	2	DB08403
Drug	trimeprazine	IVL MPO SPRR1A	1.12e-05	19	53	3	CID000005574
Drug	5-mercapto-1,3,4-thiadiazole 13c	MMP1 MMP8	1.59e-05	3	53	2	CID010030894
Drug	Hydroxamate 44	MMP1 MMP8	1.59e-05	3	53	2	CID010027203
Drug	Hydroxamate 39	MMP1 MMP8	1.59e-05	3	53	2	CID011036991
Drug	(2S)-2-[(2-nitrobenzyl)-(1,1,2,2,3,3,4,4,4-nonafluorobutylsulfonyl)amino]propanehydroxamic acid	MMP1 MMP8	1.59e-05	3	53	2	CID010994933
Drug	Hydroxamate 36	MMP1 MMP8	1.59e-05	3	53	2	CID010500886
Drug	5-mercapto-1,3,4-thiadiazole 13b	MMP1 MMP8	1.59e-05	3	53	2	CID011757336
Drug	carbamoylphosphonic acid	MMP1 MMP8	3.18e-05	4	53	2	CID013879809
Drug	3-hydroxypicolinic acid	MMP1 MMP8	3.18e-05	4	53	2	ctd:C049246
Drug	(2S)-2-[(2-nitrobenzyl)-(2,3,4,5,6-pentafluorophenyl)sulfonyl-amino]propanehydroxamic acid	MMP1 MMP8	3.18e-05	4	53	2	CID011037999
Drug	1,2-DAA	MMP1 AGRN	5.29e-05	5	53	2	CID000015652
Drug	beta-sulfone 7f	MMP1 MMP8	5.29e-05	5	53	2	CID011526076
Drug	alpha-sulfone 27e	MMP1 MMP8	5.29e-05	5	53	2	CID011719408
Drug	MMP-3 inhibitor	MMP1 MMP8	5.29e-05	5	53	2	CID010549329
Drug	Hydroxamate 33	MMP1 MMP8	5.29e-05	5	53	2	CID010810684
Drug	beta-sulfone 7e	MMP1 MMP8	5.29e-05	5	53	2	CID011641261
Drug	beta-sulfone 7b	MMP1 MMP8	5.29e-05	5	53	2	CID009867183
Drug	Hydroxamate 31	MMP1 MMP8	5.29e-05	5	53	2	CID011799753
Drug	Hydroxysulfonamide 66	MMP1 MMP8	5.29e-05	5	53	2	CID012635073
Drug	CTS-1027	MMP1 MMP8	5.29e-05	5	53	2	CID003342298
Drug	CGS 25966	MMP1 MMP8	5.29e-05	5	53	2	CID009821883
Drug	SC-276	MMP1 MMP8	5.29e-05	5	53	2	CID009802768
Drug	alpha-sulfone 35g	MMP1 MMP8	5.29e-05	5	53	2	CID011705502
Drug	Hydroxamate 34	MMP1 MMP8	5.29e-05	5	53	2	CID010529602
Drug	beta-sulfone 7d	MMP1 MMP8	5.29e-05	5	53	2	CID011548264
Drug	alpha-sulfone 27d	MMP1 MMP8	5.29e-05	5	53	2	CID011532911
Drug	alpha-sulfone 27g	MMP1 MMP8	5.29e-05	5	53	2	CID011561491
Drug	glucothiose	MMP1 MMP8	5.29e-05	5	53	2	CID000175998
Drug	I01-10485	MMP1 MMP8	5.29e-05	5	53	2	CID011009332
Drug	alpha-sulfone 27b	MMP1 MMP8	5.29e-05	5	53	2	CID011697282
Drug	beta-sulfone 7c	MMP1 MMP8	5.29e-05	5	53	2	CID011613649
Drug	glutaraldehyde	MPO MMP1 MMP8 CHM	6.83e-05	94	53	4	CID000003485
Drug	Hydroxamate 32	MMP1 MMP8	7.93e-05	6	53	2	CID010671441
Drug	Hydroxamate 26	MMP1 MMP8	7.93e-05	6	53	2	CID010833334
Drug	NSC47818	MMP1 MMP8	7.93e-05	6	53	2	CID000240910
Drug	Hydroxysulfonamide 69	MMP1 MMP8	7.93e-05	6	53	2	CID010610114
Drug	NSC-139458	MMP1 MMP8	7.93e-05	6	53	2	CID000283995
Drug	Hydroxamate 35	MMP1 MMP8	7.93e-05	6	53	2	CID010456675
Drug	2-Amino-5-mercapto-1,3,4-thiadiazole	MMP1 MMP8	7.93e-05	6	53	2	CID002723847
Drug	Hydroxamate 28	MMP1 MMP8	7.93e-05	6	53	2	CID010792025
Drug	Hydroxamate 12	MMP1 MMP8	7.93e-05	6	53	2	CID010594000
Drug	(2S)-2-[benzyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]-N-hydroxy-3-methylbutanamide	MMP1 MMP8	7.93e-05	6	53	2	CID010694926
Drug	Hydroxamate 10	MMP1 MMP8	7.93e-05	6	53	2	CID010837740
Drug	Hydroxamate 29	MMP1 MMP8	7.93e-05	6	53	2	CID010766622
Drug	Hydroxamate 8	MMP1 MMP8	7.93e-05	6	53	2	CID010758013
Drug	Hydroxamate 14	MMP1 MMP8	7.93e-05	6	53	2	CID010042482
Drug	sulfoxamine	MMP1 MMP8	7.93e-05	6	53	2	CID003000415
Drug	(2S)-2-[benzyl(1,1,2,2,3,3,4,4,4-nonafluorobutylsulfonyl)amino]-N-hydroxy-3-methylbutanamide	MMP1 MMP8	7.93e-05	6	53	2	CID010696860
Drug	0317956-0000 [391210-11-0]; Down 200; 10uM; MCF7; HT_HG-U133A	BMP7 SPRR1A DUSP5 CDKL3 IKZF5	7.96e-05	190	53	5	3966_DN
Drug	Phenelzine sulfate [156-51-4]; Down 200; 17uM; PC3; HT_HG-U133A	BMP7 PER2 SSTR4 RPH3A PLXNB1	9.00e-05	195	53	5	3802_DN
Drug	hydroxamate 20	MMP1 MMP8	1.11e-04	7	53	2	CID011792968
Drug	CGS 27023A Analog 51	MMP1 MMP8	1.11e-04	7	53	2	CID010594938
Drug	Ro 32-3555	MMP1 MMP8	1.48e-04	8	53	2	CID000193987
Drug	Sc 40827	MMP1 MMP8	1.48e-04	8	53	2	CID000127918
Drug	hydroxamate 11	MMP1 MMP8	1.48e-04	8	53	2	CID010001582
Drug	Marimastat	MMP1 MMP8	1.48e-04	8	53	2	DB00786
Drug	(1R,2R,4S,5R)-6-methylolcyclohexane-1,2,3,4,5-pentol	MMP1 MMP8	1.89e-04	9	53	2	CID011321479
Drug	CGS 27023A	MMP1 MMP8	1.89e-04	9	53	2	ctd:C097658
Drug	delta-(l-alpha-aminoadipoyl)-l-cysteinyl-glycine	IVL MPO MMP1 MMP8 CHM	1.91e-04	229	53	5	CID004369448
Drug	C11536	MPO PER2 ABCC6	2.29e-04	51	53	3	CID000443249
Drug	desmosine	MPO MMP1 ABCC6	2.57e-04	53	53	3	CID000025435
Drug	benzoyl isothiocyanate	MMP1 MMP8	2.89e-04	11	53	2	CID000068284
Drug	eckol	MPO MMP1	2.89e-04	11	53	2	CID000145937
Drug	pirfenidone	MPO BMP7 MMP1 MMP8	3.00e-04	138	53	4	CID000040632
Drug	meloxicam	MPO MMP1 MMP8	3.03e-04	56	53	3	CID000004051
Drug	AC1L1H8O	IVL TBATA MMP1	3.71e-04	60	53	3	CID000005106
Disease	Major Depressive Disorder	MPO BMP7 PCLO MMP8 CMYA5	8.27e-05	243	54	5	C1269683
Disease	Abnormality of refraction	ZNF462 BMP7 PCLO KSR2 AUTS2 PCDHA12 RGS3	2.17e-04	673	54	7	HP_0000539
Disease	thoracic aortic aneurysm (is_marker_for)	MMP1 MMP8	2.95e-04	14	54	2	DOID:14004 (is_marker_for)
Disease	Pontoneocerebellar hypoplasia	PCLO TSEN54	3.88e-04	16	54	2	cv:C1261175
Disease	visceral adipose tissue measurement, body mass index	KSR2 PCDHA12 SIK3	5.51e-04	87	54	3	EFO_0004340, EFO_0004765
Disease	carotid artery disease (is_implicated_in)	MMP1 MMP8	7.42e-04	22	54	2	DOID:3407 (is_implicated_in)
Disease	waist circumference	SUPT20HL1 CEP120 FAM178B RPH3A LDB2	1.12e-03	429	54	5	EFO_0004342
Disease	chronic obstructive pulmonary disease (biomarker_via_orthology)	MPO MMP1	1.21e-03	28	54	2	DOID:3083 (biomarker_via_orthology)
Disease	Unipolar Depression	BMP7 PCLO MMP8 CMYA5	1.30e-03	259	54	4	C0041696
Disease	Alcoholic Intoxication	MPO PER2	1.57e-03	32	54	2	C0001969

Protein segments in the cluster

Peptide	Gene	Start	Entry
QTPNPPKEVEPSPVQ	nan	91	Q6ZRG5
VTIEPPNPINPSTNC	CDKL3	401	Q8IVW4
PQQPPKPCDSQPCFH	AGRN	1326	O00468
SQPPQPVVPAKPVQC	PRMT8	31	Q9NR22
ESTKPGPVCQPPVSQ	ANKRD40	201	Q6AI12
INPETVPKPCCAPTQ	BMP7	386	P18075
NPIQPTGPSTPKPCD	MMP8	266	P22894
QEICPNEDFCPPPPN	CHM	596	P24386
NTRLKETPPPPQPNC	RAB3C	211	Q96E17
TKGPAPAPQQCSEPE	RABL6	481	Q3YEC7
EEAQPQSPAPDPPCS	RILP	371	Q96NA2
SKDVPPCQEPPPAQD	RGS3	761	P49796
PCQEPPPAQDLSPCQ	RGS3	766	P49796
PQAQDKRPAVTPQPC	FAM90A23	256	A8MXZ1
PAPQNSNPAEEPRKP	GPR158	956	Q5T848
CPSQPPVFPAAKQCP	IL18BP	51	O95998
PTTETGKENNPVCPP	KSR2	171	Q6VAB6
PPATQETKSENPPPQ	LDB2	356	O43679
PQAQDKRPAVTPQPC	FAM90A22	256	A8MWA6
PPSPNIQCDDPQPVA	ITGAE	886	P38570
PSNPTKEPVEPQPSQ	PER2	11	O15055
PQPPCTAKPDQVEPG	PCLO	1321	Q9Y6V0
PPVMPDECPQAQPTN	PLXNB1	81	O43157
VQQPPCFPLKIPPND	MPO	286	P05164
KDPCPQVAQPIPQPQ	AUTS2	296	Q8WXX7
KSEQLPPCVNPGNPV	PIERCE2	21	H3BRN8
APQVCPIPPEQSKRP	CDC42BPB	1071	Q9Y5S2
PGPLVPPDQQDKVQC	GOLGA3	31	Q08378
PPENQNPASPDVVPC	IKZF5	266	Q9H5V7
NPASPDVVPCPDEKP	IKZF5	271	Q9H5V7
TPKPCQDPPANFPLT	PROX2	321	Q3B8N5
PSSQPDSQEKPAQPP	CEFIP	366	Q711Q0
QQKPSSLPPAPCPSE	CEP120	626	Q8N960
PESPEVTQNPPTQPK	CMYA5	2146	Q8N3K9
PPTCKVQEQPPAIPE	B3GNT3	31	Q9Y2A9
CPPKNPVQCLPPASS	LCE3E	21	Q5T5B0
QAPPPKSPPVVIQCQ	CFAP47	2891	Q6ZTR5
EILPSTPNPQPPSCQ	DUSP5	316	Q16690
PQAQDKRPAVTPQPC	FAM90A24P	256	P0C7X0
LPNPPPESAPAQCKV	PCARE	1056	A6NGG8
EDCLNPPSEPRQPNP	PCDHA12	781	Q9UN75
CQPAIPENPPPAPKE	TAF6	141	P49848
KPQQPVSEPAAPEQP	RPH3A	176	Q9Y2J0
SVKPQQEQSDCPPPP	SUPT20HL1	246	Q3ZLR7
PPPCSQPSQCPEEKP	TSEN54	231	Q7Z6J9
QPSQCPEEKPQESSP	TSEN54	236	Q7Z6J9
EQSQSQPCPQPSCPP	SSPOP	4201	A2VEC9
PVQPIGPQTPKACDS	MMP1	266	P03956
PFFPEDPQQSNPCPE	ABCC6	191	O95255
EPVQAQPPQPCSSPS	RECQL4	301	O94761
DSVPLPPCQEQQPKA	FAM178B	571	Q8IXR5
PQTPEPLPKACSNPS	PPARGC1B	306	Q86YN6
CPPLPCQQEALQPEP	SSTR4	361	P31391
PQPSPPLQAACENQP	SIK3	701	Q9Y2K2
TPKESPNPPNPSGQC	MRPS18A	56	Q9NVS2
PEVHEPPQEKQEPPC	TBATA	291	Q96M53
PPQEKQEPPCSQSPK	TBATA	296	Q96M53
QKSQEDFCPPAPNPV	SPATA31D4	641	Q6ZUB0
QPTPLPPPCQKVPVE	IVL	36	P07476
PAEVPQEPQEPTQTP	PMIS2	46	A0A1W2PS18
EPCPSTVTPGPAQQK	SPRR3	151	Q9UBC9
SVKPQQEQSDCPPPP	SUPT20HL2	246	P0C7V6
QKSQEDFCPPAPNPV	SPATA31D3	641	P0C874
PPPPCKIENSIPNPN	RLF	1691	Q13129
QPKVPEPCPSTVTPA	SPRR1A	66	P35321
PVNCENSIPTPFPEQ	ZNF462	1426	Q96JM2