Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF355P RLF ZNF506 ZNF727 ZNF676 TEAD1 TEAD4 TEAD3 ZNF236 SKI ZNF341

9.62e-0614123311GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF355P ZNF506 ZNF727 ZNF676 TEAD1 TEAD4 TEAD3 ZNF236 SKI ZNF341

2.10e-0512443310GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF355P ZNF506 ZNF727 ZNF676 TEAD1 TEAD4 TEAD3 ZNF236 SKI ZNF341

2.53e-0512713310GO:0000987
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF355P ZNF506 ZNF727 ZNF676 TEAD1 TEAD4 TEAD3 ZNF236 SKI ZNF341

8.20e-0514593310GO:0000977
GeneOntologyBiologicalProcesshippo signaling

TEAD1 TEAD4 TEAD3 FRMD6

1.75e-0655334GO:0035329
GeneOntologyBiologicalProcesspositive regulation of stem cell population maintenance

TEAD1 TEAD4 TEAD3

7.37e-0551333GO:1902459
DomainTEA

TEAD1 TEAD4 TEAD3

1.65e-084313PF01285
DomainTEA_1

TEAD1 TEAD4 TEAD3

1.65e-084313PS00554
DomainTEA/ATTS_dom

TEAD1 TEAD4 TEAD3

1.65e-084313IPR000818
DomainTEF_metazoa

TEAD1 TEAD4 TEAD3

1.65e-084313IPR016361
DomainTEA

TEAD1 TEAD4 TEAD3

1.65e-084313SM00426
DomainTEA_2

TEAD1 TEAD4 TEAD3

1.65e-084313PS51088
Domain-

RLF ZNF462 ZNF506 ZNF727 PRDM8 ZNF676 ZNF236 ZNF341

1.10e-056793183.30.160.60
Domainzf-C2H2

RLF ZNF462 ZNF506 ZNF727 PRDM8 ZNF676 ZNF236 ZNF341

1.28e-05693318PF00096
DomainZnf_C2H2/integrase_DNA-bd

RLF ZNF462 ZNF506 ZNF727 PRDM8 ZNF676 ZNF236 ZNF341

1.29e-05694318IPR013087
DomainZINC_FINGER_C2H2_2

RLF ZNF462 ZNF506 ZNF727 PRDM8 ZNF676 ZNF236 ZNF341

2.86e-05775318PS50157
DomainZINC_FINGER_C2H2_1

RLF ZNF462 ZNF506 ZNF727 PRDM8 ZNF676 ZNF236 ZNF341

2.91e-05777318PS00028
DomainZnf_C2H2-like

RLF ZNF462 ZNF506 ZNF727 PRDM8 ZNF676 ZNF236 ZNF341

3.46e-05796318IPR015880
DomainZnf_C2H2

RLF ZNF462 ZNF506 ZNF727 PRDM8 ZNF676 ZNF236 ZNF341

3.75e-05805318IPR007087
DomainZnF_C2H2

RLF ZNF462 ZNF506 ZNF727 PRDM8 ZNF676 ZNF236 ZNF341

3.85e-05808318SM00355
Domainzf-C2H2_6

ZNF506 ZNF727 ZNF676 ZNF236

1.72e-03314314PF13912
DomainRHOGAP

DEPDC1 CHN1

5.04e-0364312PS50238
DomainRhoGAP_dom

DEPDC1 CHN1

5.04e-0364312IPR000198
Domain-

DEPDC1 CHN1

5.04e-03643121.10.555.10
Domain4_helix_cytokine-like_core

ZNF506 ZNF236

6.69e-0374312IPR009079
DomainRho_GTPase_activation_prot

DEPDC1 CHN1

9.34e-0388312IPR008936
PathwayWP_TRANSCRIPTION_COFACTORS_SKI_AND_SKIL_PROTEIN_PARTNERS

TEAD1 TEAD4 TEAD3 SKI

1.62e-0818234M39825
PathwayREACTOME_RUNX3_REGULATES_YAP1_MEDIATED_TRANSCRIPTION

TEAD1 TEAD4 TEAD3

7.56e-086233MM15544
PathwayREACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION

TEAD1 TEAD4 TEAD3

2.11e-078233MM14816
PathwayREACTOME_RUNX3_REGULATES_YAP1_MEDIATED_TRANSCRIPTION

TEAD1 TEAD4 TEAD3

2.11e-078233M27823
PathwayREACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION

TEAD1 TEAD4 TEAD3

1.70e-0615233M603
PathwayWP_MIR5093P_ALTERATION_OF_YAP1ECM_AXIS

TEAD1 TEAD4 TEAD3

3.05e-0618233M39421
PathwayWP_HIPPOYAP_SIGNALING

TEAD1 TEAD4 TEAD3

5.73e-0622233M39821
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

PAXIP1 ZNF355P CCNA1 ZNF727 CBX4 TEAD1 TEAD4 TEAD3 SKI

1.72e-051022239MM15436
PathwayREACTOME_GENERIC_TRANSCRIPTION_PATHWAY

ZNF355P CCNA1 ZNF727 CBX4 TEAD1 TEAD4 TEAD3 SKI

1.76e-05768238MM14851
PathwayWP_LEUKOCYTEINTRINSIC_HIPPO_PATHWAY_FUNCTIONS

TEAD1 TEAD4 TEAD3

2.40e-0535233M39430
PathwayWP_MECHANOREGULATION_AND_PATHOLOGY_OF_YAPTAZ_VIA_HIPPO_AND_NONHIPPO_MECHANISMS

TEAD1 TEAD4 TEAD3

5.87e-0547233M39829
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

CCNA1 ZNF506 ZNF727 ZNF676 CBX4 TEAD1 TEAD4 TEAD3 SKI

1.91e-041387239M734
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3

TEAD1 TEAD4 TEAD3

2.47e-0476233MM15520
PathwayPID_CMYB_PATHWAY

CCNA1 CBX4 SKI

3.32e-0484233M195
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3

TEAD1 TEAD4 TEAD3

4.91e-0496233M27784
PathwayWP_HIPPO_SIGNALING_REGULATION

TEAD1 TEAD4 TEAD3

5.22e-0498233M39830
PathwayWP_HIPPOMERLIN_SIGNALING_DYSREGULATION

TEAD1 TEAD4 TEAD3

9.64e-04121233M39823
PathwayREACTOME_DNA_REPAIR

PAXIP1 CCNA1 FANCB NPLOC4

1.31e-03301234MM15433
PathwayREACTOME_DNA_REPAIR

PAXIP1 CCNA1 FANCB NPLOC4

1.88e-03332234M15434
Pubmed

A novel family of TEA domain-containing transcription factors with distinct spatiotemporal expression patterns.

TEAD1 TEAD4 TEAD3

7.78e-1033338920920
Pubmed

A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain.

TEAD1 TEAD4 TEAD3

3.11e-0943338702974
Pubmed

VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle.

TEAD1 TEAD4 TEAD3

3.11e-09433331138678
Pubmed

Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells.

TEAD1 TEAD4 TEAD3

3.11e-09433336516960
Pubmed

Transcription factor mTEAD-2 is selectively expressed at the beginning of zygotic gene expression in the mouse.

TEAD1 TEAD4 TEAD3

3.11e-0943339169843
Pubmed

Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis.

TEAD1 TEAD4 TEAD3

3.11e-0943339889009
Pubmed

YAP/TEAD-mediated transcription controls cellular senescence.

TEAD1 TEAD4 TEAD3

3.11e-09433323576552
Pubmed

The TEA domain: a novel, highly conserved DNA-binding motif.

TEAD1 TEAD4 TEAD3

3.11e-0943332070413
Pubmed

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.

TEAD1 TEAD4 TEAD3

7.77e-09533322677547
Pubmed

Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments.

TEAD1 TEAD4 TEAD3

7.77e-09533321527258
Pubmed

Differential expression of the TEF family of transcription factors in the murine placenta and during differentiation of primary human trophoblasts in vitro.

TEAD1 TEAD4 TEAD3

7.77e-0953339671946
Pubmed

TEAD mediates YAP-dependent gene induction and growth control.

TEAD1 TEAD4 TEAD3

7.77e-09533318579750
Pubmed

TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition.

TEAD1 TEAD4 TEAD3

7.77e-09533319324877
Pubmed

TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation.

TEAD1 TEAD4 TEAD3

7.77e-09533310518497
Pubmed

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation.

TEAD1 TEAD4 TEAD3

7.77e-09533320516196
Pubmed

TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.

TEAD1 TEAD4 TEAD3

1.55e-08633311358867
Pubmed

Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor.

TEAD1 TEAD4 TEAD3

1.55e-08633325995450
Pubmed

Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3.

TEAD1 TEAD4 TEAD3

2.72e-08733314736747
Pubmed

Transcription enhancer factor 1 binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions.

TEAD1 TEAD4 TEAD3

2.72e-08733312861002
Pubmed

Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor.

TEAD1 TEAD4 TEAD3

2.72e-08733316207754
Pubmed

Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.

MYH9 TEAD1 TEAD4 TEAD3

5.99e-084033430865227
Pubmed

Expression pattern of transcriptional enhanced associate domain family member 1 (Tead1) in developing mouse molar tooth.

TEAD1 TEAD4 TEAD3

2.21e-071333333984529
Pubmed

Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors.

TEAD1 TEAD4 TEAD3

7.46e-071933320596238
Pubmed

TEAD transcription factors are required for normal primary myoblast differentiation in vitro and muscle regeneration in vivo.

TEAD1 TEAD4

8.73e-07233228178271
Pubmed

TEAD1 and TEAD3 Play Redundant Roles in the Regulation of Human Epidermal Proliferation.

TEAD1 TEAD3

8.73e-07233232142794
Pubmed

Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family.

TEAD1 TEAD4

8.73e-0723328921372
Pubmed

Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype.

TEAD1 TEAD4 TEAD3

8.77e-072033318978355
Pubmed

Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos.

TEAD1 TEAD4 TEAD3

1.36e-062333318083014
Pubmed

Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival.

TEAD1 TEAD4

2.62e-06333225628125
Pubmed

TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis.

TEAD1 TEAD4

2.62e-06333228759040
Pubmed

Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor.

TEAD1 TEAD4

2.62e-06333228077648
Pubmed

9p21.3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor-Dependent Transforming Growth Factor β Regulation of p16 Expression in Human Aortic Smooth Muscle Cells.

TEAD4 TEAD3

2.62e-06333226487755
Pubmed

Smooth muscle cells and myofibroblasts use distinct transcriptional mechanisms for smooth muscle alpha-actin expression.

TEAD1 TEAD4

2.62e-06333217823374
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF355P ZNF506 ZNF727

2.80e-062933314563677
Pubmed

Mechanosignalling via integrins directs fate decisions of pancreatic progenitors.

TEAD1 TEAD4 TEAD3

3.79e-063233330487608
Pubmed

Paraxis: a basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites.

TEAD4 TEAD3

5.23e-0643327729571
Pubmed

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.

TEAD1 TEAD4

5.23e-06433225751140
Pubmed

Tead transcription factors differentially regulate cortical development.

TEAD1 TEAD3

5.23e-06433232170161
Pubmed

cDNA cloning and characterization of mouse DTEF-1 and ETF, members of the TEA/ATTS family of transcription factors.

TEAD4 TEAD3

5.23e-0643329502435
Pubmed

Functional proteomics mapping of a human signaling pathway.

PAXIP1 RLF CBX4 SKI DNAJC7 ZNF341

1.76e-0559133615231748
Pubmed

ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.

PAXIP1 NPLOC4

1.83e-05733234144977
Pubmed

Interaction network of human early embryonic transcription factors.

PAXIP1 RLF ZNF462 TEAD1 SKI

1.91e-0535133538297188
Pubmed

Molecular architecture of lineage allocation and tissue organization in early mouse embryo.

TEAD1 TEAD4

2.44e-05833231391582
Pubmed

Meso1, a basic-helix-loop-helix protein involved in mammalian presomitic mesoderm development.

TEAD4 TEAD3

2.44e-0583327597044
Pubmed

AMPK modulates Hippo pathway activity to regulate energy homeostasis.

TEAD1 TEAD4

3.91e-051033225751139
Pubmed

The complex of Fas-associated factor 1 with Hsp70 stabilizes the adherens junction integrity by suppressing RhoA activation.

MYH9 NPLOC4

6.77e-051333235704671
Pubmed

Ski regulates Hippo and TAZ signaling to suppress breast cancer progression.

TEAD1 TEAD4 SKI

7.04e-058433325670202
Pubmed

Active conformation of the p97-p47 unfoldase complex.

MYH9 NPLOC4

9.10e-051533235552390
Pubmed

A High-Density Map for Navigating the Human Polycomb Complexome.

PAXIP1 RLF ZNF462 MYH9 CBX4

9.78e-0549533527705803
Pubmed

High-throughput mapping of a dynamic signaling network in mammalian cells.

SKI DNAJC7 CHN1 FBXO34

1.05e-0426033415761153
Pubmed

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

ZNF462 MYH9 TEAD1 DNAJC7 FBXO34

1.42e-0453633515840001
Pubmed

Exchangeable gene trap using the Cre/mutated lox system.

ZNF462 MYH9 TEAD1 DNAJC7 FBXO34

1.44e-0453833510512203
Pubmed

Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP.

TEAD1 TEAD3

2.18e-042333226933062
Pubmed

siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.

PAXIP1 FANCB

2.80e-042633223435420
Pubmed

Transcription factor TEAD1 is essential for vascular development by promoting vascular smooth muscle differentiation.

CCNA1 TEAD1

2.80e-042633231024075
Pubmed

Human transcription factor protein interaction networks.

PAXIP1 RLF ZNF462 TEAD1 TEAD3 SKI DNAJC7

3.25e-04142933735140242
Pubmed

Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6.

TEAD1 TEAD4

3.99e-043133221985497
Pubmed

Aerobic glycolysis tunes YAP/TAZ transcriptional activity.

TEAD1 TEAD4 TEAD3

4.88e-0416233325796446
Pubmed

Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking.

DNAJC7 NPLOC4

5.09e-043533222337587
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

RALGAPA1 MYH9 CRYBG3 DNAJC7 NPLOC4

5.10e-0470833539231216
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RLF ZNF462 MYH9 CRYBG3

6.39e-0441833434709266
Pubmed

Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse.

TEAD1 TEAD4

8.43e-044533226902285
Pubmed

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.

ZNF506 MYH9 ZNF236 NPLOC4

8.48e-0445133436168627
Pubmed

Hundreds of variants clustered in genomic loci and biological pathways affect human height.

ZNF462 TEAD1 ZNF341

8.74e-0419833320881960
InteractionTEAD1 interactions

PAXIP1 RLF ZNF462 TEAD1 TEAD4 SKI

3.71e-07176336int:TEAD1
InteractionVGLL1 interactions

TEAD1 TEAD4 TEAD3

2.68e-0617333int:VGLL1
InteractionVGLL4 interactions

TEAD1 TEAD4 TEAD3

1.01e-0526333int:VGLL4
InteractionVGLL2 interactions

TEAD1 TEAD3

2.59e-055332int:VGLL2
InteractionCRX interactions

PAXIP1 RLF ZNF462 TEAD1 SKI

5.44e-05254335int:CRX
CytobandEnsembl 112 genes in cytogenetic band chr14q22

FRMD6 FBXO34

2.10e-0394332chr14q22
GeneFamilyTEA domain transcription factors

TEAD1 TEAD4 TEAD3

1.05e-0842631183
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

RLF ZNF462 ZNF506 ZNF727 ZNF676 ZNF236 ZNF341

5.14e-0571826728
ToppCell343B-Lymphocytic-NK_cells-Proliferating_NK_cell|343B / Donor, Lineage, Cell class and subclass (all cells)

PAXIP1 RLF FANCB DEPDC1

7.22e-0616933402fa66a91b8bd2bf971aec4f5ec58318b5bfdf14
ComputationalNeighborhood of NCAM1

ZNF462 RALGAPA1 CRYBG3 TEAD1

7.78e-05127204GCM_NCAM1
DrugMcat

TEAD1 TEAD4 TEAD3

1.60e-0535323CID003080785
Diseasehip circumference

RALGAPA1 MYH9 TEAD1

5.28e-03338313EFO_0005093
Diseasesexual dimorphism measurement

ZNF462 RALGAPA1 TEAD1 TEAD3 ZNF341

5.53e-031106315EFO_0021796

Protein segments in the cluster

PeptideGeneStartEntry
PMNLKVIIYEKPHFH

CRYBG3

2476

Q68DQ2
MHLKPYWKLQKKEHP

FBXO34

1

Q9NWN3
LKKKKMVPPHRALHF

PAXIP1

681

Q6ZW49
PHEYRKHFPIEMKDH

EXD2

436

Q9NVH0
EPPVKHMSFHAYIRK

NPLOC4

156

Q8TAT6
AGMPLRKHRQHFKKY

DEPDC1

26

Q5TB30
KKRHEMPPHIYAITD

MYH9

141

P35579
KYLLTFPKKKPIEHM

FANCB

631

Q8NB91
RGKDYILKHIPNMHK

FRMD6

191

Q96NE9
EAEIRHRPKAHYMKK

CCNA1

221

P78396
HRPKAHYMKKQPDIT

CCNA1

226

P78396
SKKHHPYQPDPKMYD

CBX4

156

O00257
EIKKAYRKRALMHHP

DNAJC7

396

Q99615
LNREPAYKKHMPVLK

CHN1

151

P15882
IMKKFVPPDYKIHRH

TATDN2

641

Q93075
YMHPKLPTLSEKKHQ

FER1L5

1346

A0AVI2
SHHKKEYAMEPLVKR

PRDM8

646

Q9NQV8
RLMYPPHKFVVHSHK

SKI

251

P12755
LIKHKRIHMEVRPYK

ZNF727

411

A8MUV8
KLKRHMLIHEPFKKY

ZNF341

636

Q9BYN7
LMEHKRIHTGEKPYK

ZNF676

296

Q8N7Q3
QMRPKPHYVVIKKDA

RALGAPA1

271

Q6GYQ0
MQKHLRKVHPYHFKP

RLF

971

Q13129
QVKHKYMPPRSLVAK

STPG2

366

Q8N412
MINFIHKLKHLPEKY

TEAD3

371

Q99594
NYFKKKHPSMLLIPH

TTC41P

356

Q6P2S7
INFIHKLKHLPEKYM

TEAD4

371

Q15561
YMKRHPGVFPKKQHA

ZNF462

1786

Q96JM2
RKTHMQFHYKPDPKK

ZNF236

1266

Q9UL36
MYQAIKPAHKKPILV

SEMA3E

411

O15041
FTKHMIIHRGEKPYK

ZNF355P

171

Q9NSJ1
YMINFIHKLKHLPEK

TEAD1

361

P28347
KRHEMIAKPPVMYSH

ZNF506

66

Q5JVG8
LAKEHKRAPMFIYKP

MYOT

341

Q9UBF9