Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionSH3 domain binding

WIPF1 WASF2 ARHGAP27 BCAR1 UVRAG SHANK3

2.36e-05143806GO:0017124
GeneOntologyMolecularFunctiontranscription factor binding

CEBPA MED25 KLF14 MED14 PER1 DAZAP2 HES1 NR1H2 ZFPM1 SUFU TRIB1 RXRB

4.34e-057538012GO:0008134
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

SPTBN4 ZXDC BCL9L CITED4 AP2A2 VAMP2 MED14 STAP2 SYN1 SMARCC2 ZFPM1 ATG2A SUFU SHANK3 RXRB

4.97e-0511608015GO:0030674
GeneOntologyMolecularFunctioncytoskeletal protein-membrane anchor activity

SPTBN4 SYN1

9.46e-054802GO:0106006
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

CEBPA MED25 MED14 PER1 DAZAP2 HES1 NR1H2 ZFPM1 TRIB1 RXRB

1.08e-045828010GO:0140297
GeneOntologyMolecularFunctionprotein domain specific binding

ZXDC CEBPA WIPF1 AP2A2 WASF2 DAZAP2 HES1 ARHGAP27 BCAR1 CNTROB UVRAG SHANK3

1.80e-048758012GO:0019904
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

CEBPA MED25 MED14 HES1 NR1H2 ZFPM1 TRIB1 RXRB

2.64e-04417808GO:0061629
GeneOntologyMolecularFunctionmolecular adaptor activity

SPTBN4 ZXDC BCL9L CITED4 AP2A2 VAMP2 MED14 STAP2 SYN1 SMARCC2 ZFPM1 ATG2A SUFU SHANK3 RXRB

2.81e-0413568015GO:0060090
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

FOXP4 NEUROD2 CEBPA NKX2-4 KLF14 PER1 TPRX1 IRF5 HES1 NR1H2 ARID3C RXRB FOXD1 KLF2

3.88e-0412448014GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

FOXP4 NEUROD2 CEBPA NKX2-4 KLF14 PER1 TPRX1 IRF5 HES1 NR1H2 ARID3C RXRB FOXD1 KLF2

4.81e-0412718014GO:0000987
GeneOntologyMolecularFunctionchromatin DNA binding

CEBPA PER1 SMARCC2 NR1H2 RXRB

5.59e-04167805GO:0031490
GeneOntologyMolecularFunctionchromatin binding

TRIM33 CEBPA KLF14 PER1 SMARCC2 HES1 NR1H2 ARID3C CRAMP1 RXRB

7.20e-047398010GO:0003682
GeneOntologyMolecularFunctionprotein-membrane adaptor activity

SPTBN4 SYN1 ATG2A

7.78e-0445803GO:0043495
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

FOXP4 NEUROD2 CEBPA NKX2-4 KLF14 TPRX1 IRF5 HES1 NR1H2 ARID3C ZBED3 RXRB FOXD1 KLF2

1.34e-0314128014GO:0000981
GeneOntologyMolecularFunctiontranscription coactivator activity

ZXDC BCL9L CITED4 MED14 SMARCC2 RXRB

1.36e-03303806GO:0003713
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

MED25 NR1H2 RXRB

1.40e-0355803GO:0042974
GeneOntologyMolecularFunctionphospholipid binding

SPTBN4 GPAA1 AP2A2 VAMP2 KCNQ1 AMER3 ATG2A RPH3A

1.57e-03548808GO:0005543
GeneOntologyMolecularFunctionkinase binding

CEBPA AP2A2 PER1 SYN1 KCNQ1 DAZAP2 IRF5 HES1 BCAR1 SUFU TRIB1

1.62e-039698011GO:0019900
GeneOntologyMolecularFunctionphosphatidylinositol binding

GPAA1 AP2A2 KCNQ1 AMER3 ATG2A RPH3A

1.69e-03316806GO:0035091
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

FOXP4 NEUROD2 CEBPA NKX2-4 KLF14 PER1 TPRX1 IRF5 HES1 NR1H2 ARID3C RXRB FOXD1 KLF2

1.83e-0314598014GO:0000977
GeneOntologyMolecularFunctiontranscription coregulator activity

ZXDC BCL9L CITED4 MED14 SMARCC2 ZFPM1 SUFU RXRB

1.84e-03562808GO:0003712
GeneOntologyMolecularFunctionE-box binding

NEUROD2 PER1 HES1

1.89e-0361803GO:0070888
GeneOntologyMolecularFunctionnuclear vitamin D receptor binding

MED14 RXRB

2.33e-0318802GO:0042809
GeneOntologyMolecularFunctionactin binding

SPTBN4 WASL WIPF1 TPRN WASF2 SYN1 SHANK3

3.08e-03479807GO:0003779
GeneOntologyMolecularFunctionnuclear retinoid X receptor binding

MED25 NR1H2

3.80e-0323802GO:0046965
GeneOntologyMolecularFunctionprotein serine/threonine kinase binding

AP2A2 DAZAP2

4.13e-0324802GO:0120283
GeneOntologyMolecularFunctioncytoskeletal anchor activity

SPTBN4 SYN1

4.13e-0324802GO:0008093
GeneOntologyMolecularFunctioncytoskeletal protein binding

SPTBN4 WASL GPAA1 REEP1 WIPF1 TPRN WASF2 VAMP2 SYN1 EML3 SHANK3

4.28e-0310998011GO:0008092
GeneOntologyMolecularFunctionprotein kinase A regulatory subunit binding

WASF2 KCNQ1

4.48e-0325802GO:0034237
GeneOntologyMolecularFunctiondelayed rectifier potassium channel activity

KCNC3 KCNQ1

5.60e-0328802GO:0005251
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

HJV BCL9L WASL NEUROD2 CEBPA MED25 KLF14 MED14 PER1 IRF5 HES1 NR1H2 ZFPM1 ARID3C ZBED3 RXRB FOXD1 KLF2

3.92e-0613907918GO:0045944
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

HJV TRIM33 FOXP4 CEBPA MED25 PER1 SMARCC2 HES1 NR1H2 ZFPM1 SUFU PLK3 SCAF4 KLF2

4.17e-0510537914GO:0000122
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

HJV ZMYND15 TRIM33 FOXP4 CEBPA MED25 PER1 SMARCC2 HES1 NR1H2 ZFPM1 SUFU PLK3 FOXD1 SCAF4 KLF2

6.75e-0513997916GO:0045892
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

HJV ZMYND15 TRIM33 FOXP4 CEBPA MED25 PER1 SMARCC2 HES1 NR1H2 ZFPM1 SUFU PLK3 FOXD1 SCAF4 KLF2

7.60e-0514137916GO:1902679
GeneOntologyCellularComponentchromatin

TRIM33 FOXP4 NEUROD2 CEBPA NKX2-4 CPSF6 KLF14 TPRX1 SMARCC2 IRF5 HES1 NR1H2 ZFPM1 ZBED3 PLK3 RXRB FOXD1 KLF2

1.13e-0514808118GO:0000785
GeneOntologyCellularComponentclathrin-sculpted glutamate transport vesicle membrane

VAMP2 SYN1

5.25e-049812GO:0060203
GeneOntologyCellularComponentclathrin-sculpted glutamate transport vesicle

VAMP2 SYN1

5.25e-049812GO:0060199
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

BCL9L CEBPA MED25 MED14 NR1H2 RXRB

6.59e-04272816GO:0090575
DomainWH2

WASL WIPF1 WASF2

2.37e-0514773SM00246
DomainWH2

WASL WIPF1 WASF2

3.63e-0516773PF02205
DomainWH2_dom

WASL WIPF1 WASF2

8.49e-0521773IPR003124
DomainWH2

WASL WIPF1 WASF2

1.28e-0424773PS51082
DomainSANT_dom

SMARCC2 CRAMP1

5.11e-0326772IPR017884
DomainCollagen

COL26A1 C1QL4 COL5A3

5.22e-0385773IPR008160
DomainCollagen

COL26A1 C1QL4 COL5A3

5.22e-0385773PF01391
DomainSANT

SMARCC2 CRAMP1

5.92e-0328772PS51293
DomainVG_K_chnl

KCNC3 KCNQ1

8.15e-0333772IPR028325
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ZXDC FAM193B INTS5 FBRSL1 MED14 PER1 IRF5 ZFPM1 ATG2A DMWD SUFU ZBED3 PRAG1 CNTROB UVRAG TRIB1 PLK3 EML3 CRAMP1

6.98e-121105811935748872
Pubmed

WW domains provide a platform for the assembly of multiprotein networks.

WASL WIPF1 CPSF6 WASF2 SMARCC2 KHSRP SCAF4

7.69e-0815481716055720
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

WASL WIPF1 MED14 KCNQ1 SMARCC2 BCAR1 SELENON SHANK3 KHSRP

7.80e-0832981917474147
Pubmed

Genetics of synaptic vesicle function: toward the complete functional anatomy of an organelle.

VAMP2 SYN1 RPH3A

1.21e-07581310099709
Pubmed

A census of human transcription factors: function, expression and evolution.

FOXP4 NEUROD2 NKX2-4 TPRX1 IRF5 HES1 NR1H2 ZFPM1 ZBED3 CRAMP1 RXRB KLF2

1.26e-06908811219274049
Pubmed

The transcription factor XBP1 is selectively required for eosinophil differentiation.

CEBPA ZFPM1 TRIB1 KLF2

1.70e-063781426147683
Pubmed

Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiation.

VAMP2 SYN1 SHANK3

3.42e-061381314622142
Pubmed

FOXD1 is required for 3D patterning of the kidney interstitial matrix.

COL26A1 COL5A3 FOXD1

3.42e-061381336335435
Pubmed

Association of KCNQ1 and KLF14 polymorphisms and risk of type 2 diabetes mellitus: A global meta-analysis.

KLF14 KCNQ1

5.36e-06281224486580
Pubmed

Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome.

WASL WIPF1

5.36e-06281212437929
Pubmed

Identification and in Vivo Evaluation of Liver X Receptor β-Selective Agonists for the Potential Treatment of Alzheimer's Disease.

NR1H2 RXRB

5.36e-06281227011007
Pubmed

Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes in American Indians.

KLF14 KCNQ1

5.36e-06281223630301
Pubmed

Invadopodia proteins, cortactin, N-WASP and WIP differentially promote local invasiveness in ameloblastoma.

WASL WIPF1

5.36e-06281226752341
Pubmed

Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα.

CEBPA TRIB1

5.36e-06281226348894
Pubmed

A critical function for the actin cytoskeleton in targeted exocytosis of prefusion vesicles during myoblast fusion.

WASL WIPF1

5.36e-06281217419995
Pubmed

Identification of a novel DNA binding site for nuclear orphan receptor OR1.

NR1H2 RXRB

5.36e-06281210187832
Pubmed

Molecular Mechanism of CCAAT-Enhancer Binding Protein Recruitment by the TRIB1 Pseudokinase.

CEBPA TRIB1

5.36e-06281226455797
Pubmed

N-WASP and WAVE2 acting downstream of phosphatidylinositol 3-kinase are required for myogenic cell migration induced by hepatocyte growth factor.

WASL WASF2

5.36e-06281215496413
Pubmed

TRIB1 regulates LDL metabolism through CEBPα-mediated effects on the LDL receptor in hepatocytes.

CEBPA TRIB1

5.36e-06281234779419
Pubmed

Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.

WASL WIPF1 CPSF6 WASF2 SYN1

6.39e-0611181522558309
Pubmed

Suppressor of Fused restraint of Hedgehog activity level is critical for osteogenic proliferation and differentiation during calvarial bone development.

HES1 SUFU FOXD1

1.57e-052181328794157
Pubmed

RXR heterodimers orchestrate transcriptional control of neurogenesis and cell fate specification.

NR1H2 RXRB

1.60e-05381228778663
Pubmed

Waltzing with WASP.

WASL WIPF1

1.60e-05381210087612
Pubmed

COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1.

CEBPA TRIB1

1.60e-05381223884858
Pubmed

Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein.

WIPF1 WASF2

1.60e-05381210202051
Pubmed

Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion.

VAMP2 RPH3A

1.60e-05381216763567
Pubmed

WIP provides an essential link between Nck and N-WASP during Arp2/3-dependent actin polymerization.

WASL WIPF1

1.60e-05381223707428
Pubmed

Transcriptional regulation of homeostatic and disease-associated-microglial genes by IRF1, LXRβ, and CEBPα.

CEBPA NR1H2

1.60e-05381231301160
Pubmed

Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation.

PEAK3 PRAG1

1.60e-05381229503074
Pubmed

The WH1 and EVH1 domains of WASP and Ena/VASP family members bind distinct sequence motifs.

WASL WIPF1

1.60e-05381212372256
Pubmed

Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin.

WASL WASF2

1.60e-05381216483316
Pubmed

Cdc42 interacts with the exocyst complex to promote phagocytosis.

WASL WASF2

1.60e-05381223295348
Pubmed

WAVE2, N-WASP, and Mena facilitate cell invasion via phosphatidylinositol 3-kinase-dependent local accumulation of actin filaments.

WASL WASF2

1.60e-05381221769917
Pubmed

T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1.

CEBPA HES1

1.60e-05381224185616
Pubmed

Identification of the hypoxia-inducible factor 2α nuclear interactome in melanoma cells reveals master proteins involved in melanoma development.

TRIM33 MED25 MED14 SMARCC2

1.76e-056681423275444
Pubmed

Interaction network of human early embryonic transcription factors.

TRIM33 BCL9L FOXP4 SOBP FBRSL1 TPRX1 SMARCC2

1.84e-0535181738297188
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

TRIM33 FOXP4 WASF2 PER1 SMARCC2 SUFU TRIB1 RXRB FOXD1 KHSRP

3.03e-05857811025609649
Pubmed

FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors.

CEBPA ZFPM1

3.20e-05481222068055
Pubmed

WIP regulates N-WASP-mediated actin polymerization and filopodium formation.

WASL WIPF1

3.20e-05481211331876
Pubmed

Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin.

WASL WIPF1

3.20e-05481215684033
Pubmed

Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein.

WASL WASF2

3.20e-0548129950691
Pubmed

Collagen family of proteins.

COL26A1 COL5A3

3.20e-0548121916105
Pubmed

Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus.

FOXP4 PER1 HES1 NR1H2

3.25e-057781421525287
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

TRIM33 BCL9L FOXP4 CPSF6 MED14 SMARCC2

3.96e-0526881633640491
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

ZXDC FOXP4 CITED4 NEUROD2 CEBPA IRF5 NR1H2 RXRB KLF2

4.08e-0570981922988430
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

TRIM33 FOXP4 MED25 MED14 SMARCC2

4.59e-0516781520362541
Pubmed

Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.

CEBPA TRIB1

5.33e-05581220410507
Pubmed

Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells.

NR1H2 RXRB

5.33e-05581214993927
Pubmed

Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.

SMARCC2 SUFU

5.33e-05581221076395
Pubmed

Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1.

CEBPA TRIB1

5.33e-05581230254053
Pubmed

WIP modulates dendritic spine actin cytoskeleton by transcriptional control of lipid metabolic enzymes.

WASL WIPF1

5.33e-05581224698977
Pubmed

The pseudokinase TRIB1 toggles an intramolecular switch to regulate COP1 nuclear export.

CEBPA TRIB1

5.33e-05581230692133
Pubmed

Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly.

WASL WIPF1

5.33e-05581222966049
Pubmed

FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation.

WASL WASF2

5.33e-05581214697212
Pubmed

Early T-cell progenitors are the major granulocyte precursors in the adult mouse thymus.

CEBPA HES1

5.33e-05581223152541
Pubmed

IL-17 inhibits adipogenesis in part via C/EBPα, PPARγ and Krüppel-like factors.

CEBPA KLF2

5.33e-05581223332504
Pubmed

Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm.

PER1 HES1

5.33e-05581211260262
Pubmed

Human FOX gene family (Review).

FOXP4 FOXD1

5.33e-05581215492844
Pubmed

A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals.

AP2A2 SYN1

5.33e-0558128552632
Pubmed

Homozygous MED25 mutation implicated in eye-intellectual disability syndrome.

MED25 MED14

5.33e-05581225792360
Pubmed

A directed protein interaction network for investigating intracellular signal transduction.

SPTBN4 ZXDC FAM193B NEUROD2 SOBP DAZAP2 HES1 NR1H2 BTBD2 PRAG1 KHSRP

5.86e-051124811121900206
Pubmed

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

KLF14 KCNQ1 ZBED3

6.91e-053481320581827
Pubmed

Wiskott-Aldrich syndrome protein is involved in alphaIIb beta3-mediated cell adhesion.

WASL WIPF1

7.99e-05681216582881
Pubmed

Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis.

WIPF1 WASF2

7.99e-05681219798448
Pubmed

Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression.

VAMP2 SYN1

7.99e-05681216621800
Pubmed

Synaptic assembly of the brain in the absence of neurotransmitter secretion.

VAMP2 SYN1

1.12e-04781210657302
Pubmed

Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction.

SYN1 RPH3A

1.12e-04781211359932
Pubmed

Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein.

AP2A2 SYN1

1.12e-0478127671305
Pubmed

Circadian Dysfunction Induces Leptin Resistance in Mice.

CEBPA PER1

1.12e-04781226166747
Pubmed

The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response.

TRIM33 SMARCC2

1.12e-04781221382013
Pubmed

Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.

KLF14 KCNQ1 ZBED3

1.22e-044181320889853
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

TRIM33 CPSF6 FBRSL1 PER1 ATG2A DMWD NCKAP5L ZBED3 CNTROB UVRAG

1.48e-041038811026673895
Pubmed

Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex.

WASL WASF2

1.49e-04881210381382
Pubmed

Molecular determinants of synapsin targeting to presynaptic terminals.

VAMP2 SYN1

1.49e-04881215071120
Pubmed

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling.

WASL WASF2

1.49e-04881211130076
Pubmed

A single-cell transcriptomic landscape of cadmium-hindered brain development in mice.

NEUROD2 SYN1

1.49e-04881239147853
Pubmed

Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex.

WASL WASF2

1.49e-04881211146629
Pubmed

Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA.

NR1H2 RXRB

1.49e-04881229431742
Pubmed

Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development.

WASL HES1 FOXD1

1.72e-044681323555292
Pubmed

Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.

TRIM33 SMARCC2

2.38e-041081216751102
Pubmed

Physical map of 17p13 and the genes adjacent to p53.

NEUROD2 VAMP2

2.38e-041081210662545
Pubmed

Increased expression of angiogenic genes in the brains of mouse meg3-null embryos.

WASL HES1

2.38e-041081220392836
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TRIM33 INTS5 CASKIN2 FBRSL1 DAZAP2 ATG2A CRAMP1

2.38e-0452981714621295
Pubmed

Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.

ZXDC MED14 NR1H2 RXRB

2.71e-0413381415604093
Pubmed

Novel interactive partners of neuroligin 3: new aspects for pathogenesis of autism.

TRIM33 AP2A2 SPINT1

2.77e-045481325464930
Pubmed

CIN85 interacting proteins in B cells-specific role for SHIP-1.

WASL WIPF1 AP2A2

2.77e-045481321725061
Pubmed

Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.

INTS5 MED25 MED14

2.77e-045481316239144
Pubmed

Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis.

VAMP2 SYN1

2.91e-041181211753414
Pubmed

mTORC1 activity is essential for erythropoiesis and B cell lineage commitment.

CEBPA KLF2

2.91e-041181231729420
Pubmed

Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.

CEBPA MED14

2.91e-041181212037571
Pubmed

α3(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues.

VAMP2 COL5A3

2.91e-041181221293061
Pubmed

Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program.

TRIM33 SMARCC2

2.91e-041181218003620
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

BCL9L REEP1 AP2A2 CPSF6 VAMP2 PER1 SMARCC2 RPH3A SHANK3 KHSRP

3.12e-041139811036417873
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

TRIM33 FOXP4 FBRSL1 SMARCC2 SUFU NCKAP5L

3.41e-0439881635016035
Pubmed

Cholesterol and cholesterol plus DHA diet-induced gene expression and fatty acid changes in mouse eye and brain.

CEBPA RXRB

3.48e-041281215589691
Pubmed

A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction.

MED25 MED14

3.48e-041281223563140
Pubmed

Ptch1 is essential for cochlear marginal cell differentiation and stria vascularis formation.

KCNQ1 SUFU

3.48e-041281238602877
Pubmed

Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family.

PEAK3 PRAG1

3.48e-041281235192416
Pubmed

A novel docking site on Mediator is critical for activation by VP16 in mammalian cells.

MED25 MED14

4.11e-041381214657022
Pubmed

POGZ Is Required for Silencing Mouse Embryonic β-like Hemoglobin and Human Fetal Hemoglobin Expression.

ZFPM1 KLF2

4.11e-041381229898395
InteractionTOP3B interactions

ZXDC FAM193B INTS5 FBRSL1 MED14 PER1 IRF5 ZFPM1 ATG2A DMWD SUFU ZBED3 PRAG1 CNTROB UVRAG TRIB1 PLK3 EML3 CRAMP1

2.33e-0614707819int:TOP3B
CytobandEnsembl 112 genes in cytogenetic band chr19p13

CCDC194 RGL3 STAP2 COL5A3 BTBD2 PEAK3 KHSRP KLF2

9.16e-05797828chr19p13
Cytoband19q13.3

MED25 NR1H2 DMWD

4.39e-048282319q13.3
Cytoband19p13.3

STAP2 BTBD2 PEAK3 KHSRP

8.84e-0423782419p13.3
CytobandEnsembl 112 genes in cytogenetic band chr12q13

PRR13 SMARCC2 DAZAP2 C1QL4 NCKAP5L

9.89e-04423825chr12q13
Cytoband17p13.1

VAMP2 PER1 CNTROB

1.26e-0311882317p13.1
CytobandEnsembl 112 genes in cytogenetic band chr19q13

SPTBN4 CEBPA KCNC3 OSCAR MED25 TPRX1 NR1H2 DMWD

1.32e-031192828chr19q13
Cytoband12q13.12

C1QL4 NCKAP5L

2.12e-033882212q13.12
Cytoband11q12.3

INTS5 EML3

2.12e-033882211q12.3
Cytoband12q12

PRR13 DAZAP2

3.23e-034782212q12
CytobandEnsembl 112 genes in cytogenetic band chr17p13

ZMYND15 VAMP2 PER1 CNTROB

3.49e-03346824chr17p13
GeneFamilyWiskott-Aldrich Syndrome protein family

WASL WASF2

9.13e-041651214
GeneFamilyZinc fingers C2H2-type|Kruppel like factors

KLF14 KLF2

1.16e-0318512624
CoexpressionGSE23925_DARK_ZONE_VS_NAIVE_BCELL_DN

CASKIN2 VAMP2 PER1 NR1H2 NCKAP5L TRIB1 PLK3

2.47e-06200797M7881
CoexpressionTRAVAGLINI_LUNG_NEUTROPHIL_CELL

ZDHHC18 PRR13 VAMP2 PER1 ATG2A TRIB1 PLK3 KLF2

1.47e-05366798M41688
CoexpressionSTARK_HYPPOCAMPUS_22Q11_DELETION_UP

AP2A2 VAMP2 UVRAG RPH3A

2.00e-0553794MM582
CoexpressionSTARK_HYPPOCAMPUS_22Q11_DELETION_UP

AP2A2 VAMP2 UVRAG RPH3A

2.16e-0554794M12050
CoexpressionGSE36476_CTRL_VS_TSST_ACT_72H_MEMORY_CD4_TCELL_YOUNG_UP

MAPK1IP1L PER1 DAZAP2 UVRAG PLK3 KLF2

3.03e-05198796M5293
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCL9L FOXP4 CEBPA PER1 NCKAP5L TRIB1

1.24e-06186826bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXP4 CEBPA PER1 WNT10A NCKAP5L TRIB1

1.36e-06189826965e0e388251e7318f8b463816dc96ccb4658677
ToppCellPBMC-Severe-cDC_5|Severe / Compartment, Disease Groups and Clusters

CITED4 VAMP2 PER1 HES1 ATG2A KLF2

1.59e-06194826b903e23eb75733ca516770727097fe74a9f8c1d1
ToppCelldroplet-Lung-30m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l33|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZMYND15 INTS5 CITED4 COL5A3 DMWD

5.31e-06136825a43b3db1754c619d328a26a2ba6af4756629a723
ToppCellTCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Spindle_Cell-1|TCGA-Uvea / Sample_Type by Project: Shred V9

C1QL4 ZFPM1 BTBD2 SELENON EML3

1.48e-05168825b427746929bb40e3d1b5f1c40d302b792d6b32a5
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CEBPA PER1 PLK3 KLF2 FAM149A

1.52e-051698250867528101767fc65e93b3561480bf830c50368d
ToppCelldroplet-Marrow-nan-3m-Hematologic-proerythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRR13 ATG2A TRIB1 PLK3 KLF2

1.66e-05172825cfcfa7eeff1805bedf10a3c07826459914c3e872
ToppCellPBMC-Mild-cDC_8|Mild / Compartment, Disease Groups and Clusters

CEBPA VAMP2 HES1 ATG2A KLF2

2.35e-05185825891b39c20fe9858fbba90d9ef7a253f1a0870211
ToppCell18-Airway-Epithelial-Basal_cell|Airway / Age, Tissue, Lineage and Cell class

SPINT1 STAP2 WNT10A HES1 TRIB1

2.88e-051938255067b0db24f96e26cf3f9437736415f694e7a614
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CITED4 SPINT1 TPRN STAP2 ARHGAP27

2.95e-05194825550e61a40be2baa59520aaf5912bb99ad094ba15
ToppCellwk_20-22|World / Celltypes from embryonic and fetal-stage human lung

WIPF1 PRR13 DAZAP2 ARHGAP27 KLF2

3.25e-0519882556eb765773a1a27a44262a447df7cfae8a9db90d
ToppCellSevere-B_memory-0|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

PRR13 VAMP2 NR1H2 UVRAG KLF2

3.25e-051988259cc75d14f1220fe15e530115f6dff09c31f07f7c
ToppCellStriatum-Neuronal|Striatum / BrainAtlas - Mouse McCarroll V32

SPTBN4 VAMP2 SYN1 AMER3 RPH3A

3.41e-05200825c888fd487990cad482a4ca47601cdebc0ca3f3ce
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CEBPA WASF2 ARHGAP27 TRIB1 PLK3

3.41e-0520082580e0483d5ab0c6213aae0ec62619f57e6ec0e4c2
ToppCellTCGA-Ovary-Primary_Tumor|TCGA-Ovary / Sample_Type by Project: Shred V9

WASF2 SUFU NCKAP5L PRAG1

4.42e-0510682414f548be39cec604fbdae0382cbf434fa4049840
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma|TCGA-Ovary / Sample_Type by Project: Shred V9

WASF2 SUFU NCKAP5L PRAG1

4.42e-05106824939b80950d39cdc7149a05fdfb64c8810064cdb1
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma|TCGA-Ovary / Sample_Type by Project: Shred V9

WASF2 SUFU NCKAP5L PRAG1

4.42e-05106824e9e1b55f32b3d5b9eeec94a997912e5c21c1fb48
DrugCytisine (-) [485-35-8]; Down 200; 21uM; MCF7; HT_HG-U133A

ZXDC FAM193B ZDHHC18 CASKIN2 VAMP2 IRF5 NR1H2 SCAF4

4.20e-071977986217_DN
DrugOxamniquine [21738-42-1]; Down 200; 14.4uM; PC3; HT_HG-U133A

REEP1 WIPF1 CASKIN2 MED25 MED14 PER1 BTBD2

5.78e-061987974006_DN
DrugDiprophylline [479-18-5]; Up 200; 15.8uM; PC3; HT_HG-U133A

ZXDC FAM193B CASKIN2 MED14 PER1 RPH3A SCAF4

5.97e-061997971811_UP
Drugfullerene C60

HJV ZXDC NEUROD2 CEBPA CASKIN2 VAMP2 PER1 SYN1 KCNQ1 ZFPM1 BTBD2 ARHGAP27 BCAR1 TRIB1 PLK3 SHANK3 RXRB

1.19e-0514987917ctd:C069837
DrugAC1L1HRY

HJV PER1 NR1H2 RXRB

1.80e-0545794CID000004265
DrugN-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE

NR1H2 RXRB

3.56e-053792DB07080
DrugCantharidin [56-25-7]; Down 200; 20.4uM; HL60; HT_HG-U133A

TRIM33 CEBPA NR1H2 TRIB1 EML3 SCAF4

4.79e-051877963075_DN
Drug17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A_EA

ZXDC INTS5 CEBPA CASKIN2 HES1 BTBD2

4.93e-05188796986_DN
DrugBeta-Escin [11072-93-8]; Down 200; 3.2uM; MCF7; HT_HG-U133A

AP2A2 SOBP VAMP2 IRF5 PLK3 KLF2

5.39e-051917963890_DN
DrugZardaverine [101975-10-4]; Up 200; 15uM; MCF7; HT_HG-U133A

VAMP2 MED14 PER1 DMWD PLK3 EML3

5.87e-051947967347_UP
DrugGabexate mesilate [56974-61-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A

GPAA1 AP2A2 MED14 IRF5 EML3 KLF2

5.87e-051947964804_DN
DrugMinocycline hydrochloride [13614-98-7]; Down 200; 8uM; PC3; HT_HG-U133A

WIPF1 CASKIN2 VAMP2 MED14 PER1 EML3

6.04e-051957965077_DN
DrugLumicolchicine gamma [6901-14-0]; Up 200; 10uM; HL60; HT_HG-U133A

REEP1 SPINT1 VAMP2 KCNQ1 BTBD2 EML3

6.22e-051967961317_UP
DrugThiethylperazine malate [52239-63-1]; Down 200; 6uM; MCF7; HT_HG-U133A

ZXDC FAM193B CASKIN2 MED14 SMARCC2 SCAF4

6.40e-051977966232_DN
DrugProchlorperazine dimaleate [84-02-6]; Down 200; 6.6uM; MCF7; HT_HG-U133A

ZDHHC18 AP2A2 CASKIN2 MED25 MED14 SCAF4

6.40e-051977962641_DN
DrugPergolide mesylate [66104-23-2]; Down 200; 9.8uM; MCF7; HT_HG-U133A

CEBPA REEP1 AP2A2 MED14 BTBD2 EML3

6.58e-051987967031_DN
DrugDiprophylline [479-18-5]; Up 200; 15.8uM; MCF7; HT_HG-U133A

TRIM33 REEP1 SMARCC2 IRF5 PLK3 SCAF4

6.58e-051987961689_UP
Diseasebasophil percentage of granulocytes

ZDHHC18 CEBPA ZFPM1 TRIB1

7.45e-0583794EFO_0007995
Diseasehypertension

RGL3 KLF14 FBRSL1 IRF5 ARID3C BCAR1

1.78e-04307796EFO_0000537
Diseasefree cholesterol to total lipids in very large HDL percentage

NEUROD2 KLF14 TRIB1

4.38e-0455793EFO_0022288
Diseasetumor necrosis factor receptor superfamily member EDAR measurement

ZFPM1 SUFU

4.59e-0412792EFO_0008310
Diseasedickkopf‐related protein 1 measurement

ZFPM1 SUFU

4.59e-0412792EFO_0010620
Diseasevascular endothelial growth factor measurement

KCNC3 NR1H2 ZFPM1

4.62e-0456793EFO_0004762
Diseasenon-high density lipoprotein cholesterol measurement

LRFN2 CEBPA KLF14 FBRSL1 ZFPM1 TRIB1 RPH3A SCAF4

6.44e-04713798EFO_0005689
Diseasetriglyceride measurement, high density lipoprotein cholesterol measurement

ZMYND15 LRFN2 KLF14 UVRAG TRIB1

8.57e-04274795EFO_0004530, EFO_0004612
Diseasehigh density lipoprotein particle size measurement

ZDHHC18 KLF14 UVRAG TRIB1

1.14e-03170794EFO_0008592
DiseaseMeningioma

HES1 SUFU

1.18e-0319792C0025286
DiseaseC-reactive protein measurement

ZDHHC18 LRFN2 SMARCC2 IRF5 ZFPM1 PRAG1 UVRAG TRIB1 EML3 SCAF4

1.40e-0312067910EFO_0004458
DiseaseAgents acting on the renin-angiotensin system use measurement

WIPF1 CPSF6 RGL3 KLF14 TRIB1

2.08e-03335795EFO_0009931

Protein segments in the cluster

PeptideGeneStartEntry
AAPAGEGGPPAPPPN

VAMP2

11

P63027
PPTPGQPAAPPGSQG

AMER3

521

Q8N944
SPAPHAAPCPGPPPG

FBRSL1

266

Q9HCM7
PAGPGPGPPATPAQP

BCAR1

71

P56945
GPGPAPPATQSSPGP

ARID3C

251

A6NKF2
GPDGAPASVPPFPPG

C1QL4

41

Q86Z23
PQPPQPPPGPASASG

DMWD

56

Q09019
PGAAGPASSPPPAGP

DMWD

71

Q09019
PASSPPPAGPGPGPA

DMWD

76

Q09019
SGAPPPSPPVGGPAG

ATG2A

1321

Q2TAZ0
AAPPAPAGPPPSSGG

AP2A2

666

O94973
APPPPRGPALPGAGS

HJV

126

Q6ZVN8
PPAGGSPAPPGPAPA

FOXD1

81

Q16676
TAGNIPPPPPGCPPN

DAZAP2

121

Q15038
PGAPGPAPPASPAAP

KCNQ1

56

P51787
PGQAGPQPPAPTPAP

NKX2-4

296

Q9H2Z4
PSRPSPTPQGPPFGG

NCKAP5L

1276

Q9HCH0
PGGAPGPSVPLPPSQ

GPAA1

406

O43292
APPQPPTPSGGGCSP

FAM149A

106

A5PLN7
PGANATAPPGDPPPG

CCDC194

51

A0A1B0GVG4
PSPGPPQHRPCPGPS

PER1

26

O15534
LQPPGPPGSPGPHAP

PEAK3

336

Q6ZS72
AAGAPPPPPPGHAPA

ZFPM1

751

Q8IX07
GPPGAPKPPPASQPS

MED25

331

Q71SY5
AQPPPGAPQGPPGAA

MED25

611

Q71SY5
GAPQGPPGAASGPPP

MED25

616

Q71SY5
GPPLGAPNPSASGPP

FOXP4

651

Q8IVH2
GGSPGGAQPPSPVPP

MSLNL

501

Q96KJ4
GAQPPSPVPPGGAPV

MSLNL

506

Q96KJ4
DPSPLAPPPGNPAGF

IRF5

196

Q13568
PGGSNPAHPPPINPP

PRR13

21

Q9NZ81
CPPPPGAPHGNPAFP

PRR13

41

Q9NZ81
PAGSPPASPGPQGPS

RGL3

566

Q3MIN7
GSPSSPAPGPPPGAP

CASKIN2

761

Q8WXE0
AGPSEPPGPPAPAGP

CASKIN2

911

Q8WXE0
SGGPPSAPAPPPPGA

MED14

21

O60244
PGMQAPGPPPSDPGA

OSCAR

231

Q8IYS5
GASAGPGPPLPPARP

PANO1

146

I0J062
AGPGGPPPPFPAGQT

CPSF6

221

Q16630
PPPPPSLEAGAGAGP

FAM193B

31

Q96PV7
GAGPAQPPAPPAAPE

CEBPA

36

P49715
ADGPPAPPGAPQAPS

CRAMP1

56

Q96RY5
PPPPPQGSGPGISNS

BCL9L

1126

Q86UU0
ALPGPGPPGPASVPQ

KLF14

51

Q8TD94
SPGPPGLSNGPPAPQ

EML3

96

Q32P44
AAAAPGPTPPAPPGP

BTBD2

51

Q9BX70
ASPPPPQAPFGFPGD

SCAF4

311

O95104
DTGPAGPPGPPGAPA

COL5A3

1476

P25940
GPPGPAGNPGPSPNS

COL26A1

256

Q96A83
NPPAPPAGPSSPGPQ

CNTROB

576

Q8N137
PGPGGPQHAPFAPPP

HES1

171

Q14469
APFPPSGPSCPPPGG

MAPK1IP1L

86

Q8NDC0
SGPSCPPPGGPYPAP

MAPK1IP1L

91

Q8NDC0
QPPGPVPGPAPAPAA

KHSRP

586

Q92945
GAPGREPPASPAPPG

FOXL3

171

A0A1W2PRP0
PPPPPGAHSPGATPG

SYN1

31

P17600
SVGGPVPQPPPGPAA

UVRAG

6

Q9P2Y5
PSAPGPGPAPCTGGP

STAP2

271

Q9UGK3
PASAPAPGPSAGPPP

TRIM33

101

Q9UPN9
APGPSAGPPPGPPAS

TRIM33

106

Q9UPN9
PAPPQPGQPGTPGGS

RPH3A

286

Q9Y2J0
TPLPGNGPPQPGAPS

NR1H2

11

P55055
GNPAAAAPPGPHPSP

ARHGAP27

71

Q6ZUM4
GDGAPAPSGPPPPGS

REEP1

161

Q9H902
DPPGAPGPPGPAPAT

INTS5

6

Q6P9B9
PGPPGPAPATHGPAP

INTS5

11

Q6P9B9
PPGSQPIPPTGAAGP

SMARCC2

966

Q8TAQ2
GSPGLPPPAPPGFSG

RXRB

141

P28702
AAPPNAPGGPPGPQP

CITED4

101

Q96RK1
APGGPPGPQPAPSAA

CITED4

106

Q96RK1
AGSSPPAAPCPPPPG

ZBED3

106

Q96IU2
AAAAPAPPAGPGPPP

PLK3

16

Q9H4B4
APPAGPGPPPSALRG

PLK3

21

Q9H4B4
PISGPFSGPNPGPIP

TPRX1

166

Q8N7U7
GPSGPAAPPGPGVAP

ZXDC

111

Q2QGD7
PCSPQPPPAAPGAGG

TRIB1

66

Q96RU8
PLPSPASGPGPGAPG

SHANK3

1641

Q9BYB0
PPPGGPRNLGPTSSP

SOBP

436

A7XYQ1
QGTQAGPPPAPPGLP

SPINT1

31

O43278
PGQRGPPSPGPAAQP

SELENON

6

Q9NZV5
PSGAPGPTAPPAPGP

SUFU

6

Q9UMX1
APAQGGSAPAPPPPP

SPTBN4

2401

Q9H254
RQPSPGPTPPPFPGN

WIPF1

211

O43516
GPGPAPAPAPAPAPA

PRAG1

1161

Q86YV5
GPPPPPFTGADGQPA

WASF2

401

Q9Y6W5
PAAPSPPAAPGPRGG

TPRN

171

Q4KMQ1
NSGPPPPPARGRGAP

WASL

296

O00401
EPGPAGAPSPAPGAP

WNT10A

311

Q9GZT5
QGSGARPAPGPPPPS

ZMYND15

701

Q9H091
GPAASPTPGPGPAPP

ZDHHC18

26

Q9NUE0
APGPRASFPPPFGGP

KLF2

186

Q9Y5W3
PGPAASPAGPPAPRG

KCNC3

46

Q14003
PPSSAPAGAPPQGPP

LRFN2

586

Q9ULH4
PPAPGPGAPGPARAA

NEUROD2

41

Q15784