Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

2.21e-1437488GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

2.79e-1438488GO:0070001
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-6 LARP6 ERVK-8 ERVK-7 ERVK-10

1.28e-0921485GO:0035613
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-6 ERVK-8 ERVK-7 ERVK-10

9.58e-0911484GO:0004523
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-6 ERVK-8 ERVK-7 ERVK-10

2.89e-0814484GO:0003964
GeneOntologyMolecularFunctionzinc ion binding

ERVK-6 HIVEP1 DRP2 MYO9B ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ZNF90 ERVK-24

1.15e-078914813GO:0008270
GeneOntologyMolecularFunctiontransition metal ion binding

ERVK-6 HIVEP1 DRP2 MYO9B ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ZNF90 ERVK-24 F5

4.66e-0711894814GO:0046914
GeneOntologyMolecularFunctionendopeptidase activity

ERVK-6 USP8 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

7.30e-07430489GO:0004175
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-6 ERVK-8 ERVK-7 ERVK-10

1.83e-0637484GO:0016891
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-6 ERVK-8 ERVK-7 ERVK-10

2.04e-0638484GO:0034061
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-6 ERVK-8 ERVK-7 ERVK-10

4.45e-0646484GO:0016893
GeneOntologyMolecularFunctionpeptidase activity

ERVK-6 USP8 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

2.19e-05654489GO:0008233
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-6 ERVK-8 ERVK-7 ERVK-10

3.87e-0579484GO:0004521
GeneOntologyMolecularFunctionstructural molecule activity

ERVK-6 ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 EPB41

4.15e-058914810GO:0005198
GeneOntologyMolecularFunctionRNA nuclease activity

ERVK-6 ERVK-8 ERVK-7 ERVK-10

3.18e-04136484GO:0004540
GeneOntologyMolecularFunctionendonuclease activity

ERVK-6 ERVK-8 ERVK-7 ERVK-10

3.18e-04136484GO:0004519
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

ERVK-6 BPTF ERVK-8 ERVK-7 ERVK-10

4.04e-04262485GO:0140097
GeneOntologyMolecularFunctionG protein-coupled purinergic nucleotide receptor activity

P2RY14 PTAFR

4.34e-0413482GO:0045028
GeneOntologyMolecularFunctioncatalytic activity, acting on RNA

ERVK-6 ERVK-8 TRMT11 ERVK-7 ERVK-10 DDX10

4.68e-04417486GO:0140098
GeneOntologyMolecularFunctionnucleotidyltransferase activity

ERVK-6 ERVK-8 ERVK-7 ERVK-10

4.84e-04152484GO:0016779
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

ERVK-6 BPTF ERVK-8 TRMT11 ERVK-7 ERVK-10 DDX10

8.27e-04645487GO:0140640
GeneOntologyMolecularFunctionnucleotide receptor activity

P2RY14 PTAFR

1.27e-0322482GO:0016502
GeneOntologyMolecularFunctionpurinergic nucleotide receptor activity

P2RY14 PTAFR

1.27e-0322482GO:0001614
GeneOntologyMolecularFunctionnuclease activity

ERVK-6 ERVK-8 ERVK-7 ERVK-10

2.28e-03231484GO:0004518
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

ERVK-6 STK26 PRKAB1 ERVK-8 ERVK-7 ERVK-10 STK25

6.75e-03938487GO:0016772
GeneOntologyBiologicalProcessDNA integration

ERVK-6 ERVK-8 ERVK-7 ERVK-10

1.82e-0813484GO:0015074
GeneOntologyBiologicalProcessviral process

ERVK-6 ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

1.05e-06464489GO:0016032
GeneOntologyBiologicalProcesscell-cell fusion

ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9

1.57e-0685485GO:0140253
GeneOntologyBiologicalProcesssyncytium formation by plasma membrane fusion

ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9

1.57e-0685485GO:0000768
GeneOntologyBiologicalProcesssyncytium formation

ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9

1.98e-0689485GO:0006949
GeneOntologyBiologicalProcessDNA synthesis involved in DNA repair

ERVK-6 ERVK-8 ERVK-7 ERVK-10

4.66e-0648484GO:0000731
GeneOntologyBiologicalProcessRNA-templated DNA biosynthetic process

ERVK-6 ERVK-8 ERVK-7 ERVK-10

4.14e-0583484GO:0006278
GeneOntologyBiologicalProcessDNA-templated DNA replication

ERVK-6 BRCA2 ERVK-8 ERVK-7 ERVK-10

5.74e-05178485GO:0006261
GeneOntologyBiologicalProcessG protein-coupled purinergic nucleotide receptor signaling pathway

P2RY14 PTAFR

4.07e-0413482GO:0035589
DomainETV3

ETV3 ETV3L

4.47e-062402IPR032929
Domainzf-CCHC

ERVK-6 ERVK-5

1.10e-0323402PF00098
DomainZINC_FINGER_C2H2_2

HIVEP1 ZNF273 ZNF804B ZNF347 ZFPM1 ZNF90 ZNF682

1.16e-03775407PS50157
DomainZINC_FINGER_C2H2_1

HIVEP1 ZNF273 ZNF804B ZNF347 ZFPM1 ZNF90 ZNF682

1.18e-03777407PS00028
DomainZnf_C2H2-like

HIVEP1 ZNF273 ZNF804B ZNF347 ZFPM1 ZNF90 ZNF682

1.36e-03796407IPR015880
DomainZnf_C2H2

HIVEP1 ZNF273 ZNF804B ZNF347 ZFPM1 ZNF90 ZNF682

1.45e-03805407IPR007087
DomainZnF_C2H2

HIVEP1 ZNF273 ZNF804B ZNF347 ZFPM1 ZNF90 ZNF682

1.48e-03808407SM00355
DomainEts

ETV3 ETV3L

1.63e-0328402PF00178
DomainETS_DOMAIN_1

ETV3 ETV3L

1.63e-0328402PS00345
DomainETS_DOMAIN_2

ETV3 ETV3L

1.63e-0328402PS00346
DomainETS

ETV3 ETV3L

1.63e-0328402SM00413
DomainEts_dom

ETV3 ETV3L

1.63e-0328402IPR000418
DomainETS_DOMAIN_3

ETV3 ETV3L

1.63e-0328402PS50061
DomainZF_CCHC

ERVK-6 ERVK-5

2.54e-0335402PS50158
Domain-

HIVEP1 ZNF273 ZNF347 ZFPM1 ZNF90 ZNF682

3.02e-036794063.30.160.60
Domainzf-C2H2

HIVEP1 ZNF273 ZNF347 ZFPM1 ZNF90 ZNF682

3.34e-03693406PF00096
DomainZnf_C2H2/integrase_DNA-bd

HIVEP1 ZNF273 ZNF347 ZFPM1 ZNF90 ZNF682

3.36e-03694406IPR013087
DomainZnF_C2HC

ERVK-6 ERVK-5

6.18e-0355402SM00343
DomainZnf_CCHC

ERVK-6 ERVK-5

6.18e-0355402IPR001878
DomainC1_1

MYO9B UNC13C

6.63e-0357402PF00130
DomainKRAB

ZNF273 ZNF347 ZNF90 ZNF682

7.04e-03358404PS50805
DomainKRAB

ZNF273 ZNF347 ZNF90 ZNF682

7.04e-03358404PF01352
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-6 ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

1.19e-149450921542922
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-6 ERVK-7 ERVK-10 ERVK-24

3.78e-12450410469592
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-6 ERVK-5 ERVK-19 ERVK-10

3.78e-1245047983737
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9

3.93e-121250514557543
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-19 ERVK-7 ERVK-21

1.89e-11550412629516
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-21 ERVK-9 ERVK-10 ERVK-24

1.14e-081850418664271
Pubmed

Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.

ERVK-6 ERVK-5 ERVK-7

2.79e-08550311401426
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-19 ERVK-9

5.57e-08650315063128
Pubmed

Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

ERVK-6 ERVK-19 ERVK-21

3.33e-071050312970426
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

2.03e-0625029060628
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

2.03e-0625029460924
Pubmed

Structural basis for the unique heterodimeric assembly between cerebral cavernous malformation 3 and germinal center kinase III.

STK26 STK25

6.07e-06350223665169
Pubmed

Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.

ERVK-6 ERVK-19

6.07e-06350210516026
Pubmed

SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions.

STK26 STK25

6.07e-06350223889253
Pubmed

Differential expression of MST4, STK25 and PDCD10 between benign prostatic hyperplasia and prostate cancer.

STK26 STK25

6.07e-06350225550858
Pubmed

Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.

ERVK-6 ERVK-9

6.07e-0635029971820
Pubmed

CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization.

STK26 STK25

6.07e-06350221561863
Pubmed

Plasma osteoprotegerin and breast cancer risk in BRCA1 and BRCA2 mutation carriers.

BRCA2 TNFRSF11B

6.07e-06350227893411
Pubmed

Physical activity and Mediterranean diet as potential modulators of osteoprotegerin and soluble RANKL in gBRCA1/2 mutation carriers: results of the lifestyle intervention pilot study LIBRE-1.

BRCA2 TNFRSF11B

1.21e-05450234570303
Pubmed

YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta.

STK26 STK25

1.21e-05450215037601
Pubmed

Osteoprotegerin (OPG), The Endogenous Inhibitor of Receptor Activator of NF-κB Ligand (RANKL), is Dysregulated in BRCA Mutation Carriers.

BRCA2 TNFRSF11B

1.21e-05450226629528
Pubmed

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.

STK26 STK25

3.03e-05650221423148
Pubmed

CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation.

STK26 STK25

4.23e-05750220332113
Pubmed

Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress.

STK26 STK25

4.23e-05750222291017
Pubmed

STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development.

STK26 STK25

7.25e-05950234518307
Pubmed

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.

BPTF BRCA2

6.95e-042750223395962
Cytoband19p12

ZNF66 ZNF90 ZNF682

1.26e-049049319p12
CytobandEnsembl 112 genes in cytogenetic band chr19p12

ZNF66 ZNF90 ZNF682

3.09e-04122493chr19p12
CytobandEnsembl 112 genes in cytogenetic band chr7q21

SAMD9 SLC25A40 ZNF804B

9.26e-04178493chr7q21
GeneFamilyProtein phosphatase catalytic subunits|STRIPAK complex

STK26 STK25

4.96e-04203021371
GeneFamilyETS transcription factor family

ETV3 ETV3L

9.79e-0428302534
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

HIVEP1 ZNF273 ZNF347 ZFPM1 ZNF90 ZNF682

1.01e-0371830628
Diseasecerebral cavernous malformation (implicated_via_orthology)

STK26 STK25

1.03e-0411412DOID:0060669 (implicated_via_orthology)
Diseaselevel of triacylglycerol (56:6) in blood serum

ZNF90 ZNF682

2.23e-0416412OBA_2020007
Diseasenon-high density lipoprotein cholesterol measurement

BPTF HIVEP1 BRCA2 TMEM70 ZFPM1 ZNF90

4.26e-04713416EFO_0005689
Diseasenon-melanoma skin carcinoma

BRCA2 ACTR10 ZFPM1 EPB41

4.96e-04265414EFO_0009260
Diseaseinsulin sensitivity measurement, glucose homeostasis measurement

UNC13C DDX10

1.64e-0343412EFO_0004471, EFO_0006896
Diseaseidiopathic osteonecrosis of the femoral head

SAMD9 ZNF804B

2.39e-0352412EFO_1001930
DiseaseHeschl's gyrus morphology measurement

ZNF804B P2RY14

2.48e-0353412EFO_0005852
DiseaseMYELODYSPLASTIC SYNDROME

SAMD9 BRCA2

3.93e-0367412C3463824

Protein segments in the cluster

PeptideGeneStartEntry
KVLKISYKRSSFFIK

EPB41

436

P11171
RILHKTKGKRFTYKF

ETV3

101

P41162
KSSIYKTKCIKSHLR

GVINP1

581

Q7Z2Y8
FEFKHYKPKKRFTST

AIDA

241

Q96BJ3
FHLRTSYKKKTKSSK

BPTF

1171

Q12830
LPSYRKFVTKSSKKS

BPTF

1831

Q12830
KYKKALGTKTFRIHT

ACTR10

331

Q9NZ32
KSFKRTKKSYSSTLR

MTMR10

571

Q9NXD2
KFTKSKTVYSILRHV

EIF2S1

101

P05198
QKSKKSSTFKFYRRH

IL17RE

101

Q8NFR9
IKFSSLSTFIAHKKY

ZFPM1

981

Q8IX07
STHKSKKKIREYYRL

DNAJC28

41

Q9NX36
YVSVKLLTSFKKVKH

LARP6

126

Q9BRS8
SKIKSKYASYLSFIK

ERVK-10

6

P87889
SKIKSKYASYLSFIK

ERVK-19

6

Q9YNA8
SKIKSKYASYLSFIK

ERVK-21

6

P62683
SKIKSKYASYLSFIK

ERVK-24

6

P63145
SKTKSKYASYLSFIK

ERVK-5

6

Q9HDB9
SKIKSKYASYLSFIK

ERVK-6

6

Q7LDI9
SKIKSKYASYLSFIK

ERVK-7

6

P63130
SKIKSKYASYLSFIK

ERVK-8

6

P62685
SKIKSKYASYLSFIK

ERVK-9

6

P63126
SKIKSKYASYLSFIK

HERVK_113

6

P62684
STLKKKTNKFIYAIH

BRCA2

581

P51587
QVSKKHIIYSTFLSK

CLLU1

96

Q5K131
ISVLYSFLRSHLKKK

DDX10

301

Q13206
ILHKTKGKRFTYKFN

ETV3L

106

Q6ZN32
TTLKNKFRSKHYFSK

DRP2

671

Q13474
STYKIKIHTFNKTLT

TRMT11

106

Q7Z4G4
SKKFSYVELHRFVSK

SLC25A40

171

Q8TBP6
KKVVFRKYLDSTFTK

F5

1616

P12259
FIQYKHFSLFKKKTV

FER1L5

1866

A0AVI2
HKFIVKNSKKTSYLT

STK26

271

Q9P289
LTKKFRKHLTEKFYS

PTAFR

296

P25105
YLTKLKFSLKKSFDF

SAMD9

1256

Q5K651
KSKTLFSKAKSYYRR

ARHGAP5

1156

Q13017
YTAITKKIFKSHLKS

P2RY14

206

Q15391
KHKFITRYTKKTSFL

STK25

266

O00506
KDYSSFLSRKSKIKI

SNX31

411

Q8N9S9
SKIKSKYASYLSFIK

ERVK-9

6

P63128
LSATHRYKKKYVTTL

PRKAB1

251

Q9Y478
FKRSTTLTKHKRIYT

ZNF273

411

Q14593
KKTIRFLHSFTMYKL

TNFRSF11B

366

O00300
SFPSYISRFKKHKLI

ZNF804B

626

A4D1E1
KSPKFSYTFKSTVKK

UNC13C

51

Q8NB66
KVFKRFSYLTKHKRI

ZNF682

376

O95780
KTHISKKYLKDFISS

ZNF347

231

Q96SE7
KAFISSSLLYKHKIS

ZNF90

376

Q03938
KDFKYSSTLTRHKKI

ZNF66

516

Q6ZN08
KHVFTTFYAKTKSLL

TMEM70

206

Q9BUB7
ISTKSYVHSALKIFK

USP8

31

P40818
FSFKTKSNLYKHKKS

HIVEP1

441

P15822
DSKSTFKRLFLHKTK

MYO9B

1411

Q13459