Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF134 SP3 ZFAT ZNF562 ZNF274 ZNF157 ZNF175 ZNF521 ZNF571 ZNF397 ZNF251 OVOL2 ZNF419 ZNF776 ZNF526 OVOL1 ZNF100 FEZF1 ZNF382 ZNF728 ZNF253 ZNF66 ZNF506 PRDM15 GLIS1 ZNF345	1.05e-10	1244	96	26	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF134 SP3 ZFAT ZNF562 ZNF274 ZNF157 ZNF175 ZNF521 ZNF571 ZNF397 ZNF251 OVOL2 ZNF419 ZNF776 ZNF526 OVOL1 ZNF100 FEZF1 ZNF382 ZNF728 ZNF253 ZNF66 ZNF506 PRDM15 GLIS1 ZNF345	1.68e-10	1271	96	26	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF134 SP3 ZFAT ZNF562 ZNF274 ZNF157 ZNF175 ZNF521 ZNF571 ZNF397 ZNF251 OVOL2 ZNF419 ZNF776 ZNF526 OVOL1 ZNF100 FEZF1 ZNF382 ZNF728 ZNF253 ZNF66 ZNF506 PRDM15 ZNF614 GLIS1 ZNF345	3.08e-10	1412	96	27	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF134 SP3 ZFAT ZNF562 ZNF274 ZNF157 ZNF175 ZNF521 ZNF571 ZNF397 ZNF251 OVOL2 ZNF419 ZNF776 ZNF526 OVOL1 ZNF100 FEZF1 ZNF382 ZNF728 ZNF253 ZNF66 ZNF506 PRDM15 ZNF614 GLIS1 ZNF345	6.35e-10	1459	96	27	GO:0000977
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR2	1.36e-04	4	96	2	GO:0005219
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF134 SP3 ZNF175 OVOL2 OVOL1 FEZF1 ZNF382 GLIS1	1.56e-04	320	96	8	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF134 SP3 ZNF175 OVOL2 OVOL1 FEZF1 ZNF382 GLIS1	1.77e-04	326	96	8	GO:0001217
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR2	3.39e-04	6	96	2	GO:0048763
GeneOntologyMolecularFunction	ubiquitin-modified histone reader activity	RNF169 JARID2	4.73e-04	7	96	2	GO:0061649
Domain	zf-C2H2	BNC2 ZNF134 SP3 ZFAT ZNF562 ZNF274 ZNF157 ZNF175 ZNF521 ZNF407 ZNF571 ZNF397 ZNF230 ZNF251 OVOL2 ZNF419 ZNF776 ZNF526 OVOL1 ZNF100 FEZF1 ZNF382 ZNF728 ZNF253 ZNF506 ZNF542P PRDM15 ZNF614 ZNF653 GLIS1 ZNF345	2.45e-21	693	95	31	PF00096
Domain	ZINC_FINGER_C2H2_2	BNC2 ZNF134 SP3 ZFAT ZNF562 ZNF274 ZNF157 ZNF175 ZNF521 ZNF407 ZNF571 ZNF397 ZNF230 ZNF251 OVOL2 ZNF419 ZNF776 ZNF526 OVOL1 ZNF100 FEZF1 ZNF382 ZNF728 ZNF253 ZNF506 ZNF542P PRDM15 ZNF614 ZNF653 GLIS1 ZNF345	6.37e-20	775	95	31	PS50157
Domain	ZINC_FINGER_C2H2_1	BNC2 ZNF134 SP3 ZFAT ZNF562 ZNF274 ZNF157 ZNF175 ZNF521 ZNF407 ZNF571 ZNF397 ZNF230 ZNF251 OVOL2 ZNF419 ZNF776 ZNF526 OVOL1 ZNF100 FEZF1 ZNF382 ZNF728 ZNF253 ZNF506 ZNF542P PRDM15 ZNF614 ZNF653 GLIS1 ZNF345	6.86e-20	777	95	31	PS00028
Domain	Znf_C2H2	BNC2 ZNF134 SP3 ZFAT ZNF562 ZNF274 ZNF157 ZNF175 ZNF521 ZNF407 ZNF571 ZNF397 ZNF230 ZNF251 OVOL2 ZNF419 ZNF776 ZNF526 OVOL1 ZNF100 FEZF1 ZNF382 ZNF728 ZNF253 ZNF506 ZNF542P PRDM15 ZNF614 ZNF653 GLIS1 ZNF345	1.91e-19	805	95	31	IPR007087
Domain	ZnF_C2H2	BNC2 ZNF134 SP3 ZFAT ZNF562 ZNF274 ZNF157 ZNF175 ZNF521 ZNF407 ZNF571 ZNF397 ZNF230 ZNF251 OVOL2 ZNF419 ZNF776 ZNF526 OVOL1 ZNF100 FEZF1 ZNF382 ZNF728 ZNF253 ZNF506 ZNF542P PRDM15 ZNF614 ZNF653 GLIS1 ZNF345	2.12e-19	808	95	31	SM00355
Domain	-	ZNF134 SP3 ZFAT ZNF562 ZNF274 ZNF157 ZNF175 ZNF521 ZNF407 ZNF571 ZNF397 ZNF230 ZNF251 OVOL2 ZNF419 ZNF776 ZNF526 OVOL1 ZNF100 FEZF1 ZNF382 ZNF728 ZNF253 ZNF506 PRDM15 ZNF614 ZNF653 GLIS1 ZNF345	2.25e-19	679	95	29	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF134 SP3 ZFAT ZNF562 ZNF274 ZNF157 ZNF175 ZNF521 ZNF407 ZNF571 ZNF397 ZNF230 ZNF251 OVOL2 ZNF419 ZNF776 ZNF526 OVOL1 ZNF100 FEZF1 ZNF382 ZNF728 ZNF253 ZNF506 PRDM15 ZNF614 ZNF653 GLIS1 ZNF345	4.07e-19	694	95	29	IPR013087
Domain	Znf_C2H2-like	BNC2 ZNF134 SP3 ZFAT ZNF562 ZNF274 ZNF157 ZNF175 ZNF521 ZNF407 ZNF571 ZNF397 ZNF230 ZNF251 OVOL2 ZNF419 ZNF776 ZNF526 OVOL1 ZNF100 FEZF1 ZNF382 ZNF728 ZNF253 ZNF506 PRDM15 ZNF614 ZNF653 GLIS1 ZNF345	1.54e-18	796	95	30	IPR015880
Domain	KRAB	ZNF562 ZNF274 ZNF157 ZNF175 ZNF571 ZNF230 ZNF251 ZNF419 ZNF776 ZNF100 ZNF382 ZNF728 ZNF253 ZNF506 ZNF614	3.56e-10	358	95	15	PS50805
Domain	KRAB	ZNF562 ZNF274 ZNF157 ZNF175 ZNF571 ZNF230 ZNF251 ZNF419 ZNF776 ZNF100 ZNF382 ZNF728 ZNF253 ZNF506 ZNF614	3.56e-10	358	95	15	PF01352
Domain	KRAB	ZNF562 ZNF274 ZNF157 ZNF175 ZNF571 ZNF230 ZNF251 ZNF419 ZNF776 ZNF100 ZNF382 ZNF728 ZNF253 ZNF506 ZNF614	5.41e-10	369	95	15	SM00349
Domain	KRAB	ZNF562 ZNF274 ZNF157 ZNF175 ZNF571 ZNF230 ZNF251 ZNF419 ZNF776 ZNF100 ZNF382 ZNF728 ZNF253 ZNF506 ZNF614	5.61e-10	370	95	15	IPR001909
Domain	zf-C2H2_6	ZNF562 ZNF157 ZNF521 ZNF571 ZNF251 ZNF419 ZNF526 ZNF100 FEZF1 ZNF382 ZNF728 ZNF253 ZNF506 ZNF345	6.49e-10	314	95	14	PF13912
Domain	TF_Ovo-like	OVOL2 OVOL1	2.56e-05	2	95	2	IPR027755
Domain	Ryanrecept_TM4-6	RYR1 RYR2	7.65e-05	3	95	2	IPR009460
Domain	RyR	RYR1 RYR2	7.65e-05	3	95	2	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR2	7.65e-05	3	95	2	IPR003032
Domain	RR_TM4-6	RYR1 RYR2	7.65e-05	3	95	2	PF06459
Domain	Ryan_recept	RYR1 RYR2	7.65e-05	3	95	2	IPR013333
Domain	RIH_assoc	RYR1 RYR2	3.79e-04	6	95	2	PF08454
Domain	RIH_assoc-dom	RYR1 RYR2	3.79e-04	6	95	2	IPR013662
Domain	RIH_dom	RYR1 RYR2	3.79e-04	6	95	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR2	3.79e-04	6	95	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR2	3.79e-04	6	95	2	IPR015925
Domain	-	RYR1 RYR2	3.79e-04	6	95	2	1.25.10.30
Domain	RYDR_ITPR	RYR1 RYR2	3.79e-04	6	95	2	PF01365
Domain	Ins145_P3_rec	RYR1 RYR2	3.79e-04	6	95	2	PF08709
Domain	MIR	RYR1 RYR2	1.12e-03	10	95	2	PS50919
Domain	MIR	RYR1 RYR2	1.12e-03	10	95	2	PF02815
Domain	MIR	RYR1 RYR2	1.12e-03	10	95	2	SM00472
Domain	MIR_motif	RYR1 RYR2	1.12e-03	10	95	2	IPR016093
Domain	-	FEN1 MARF1	1.63e-03	12	95	2	3.40.50.1010
Domain	PIN_domain-like	FEN1 MARF1	2.24e-03	14	95	2	IPR029060
Domain	zf-H2C2_2	OVOL1 ZNF345	2.24e-03	14	95	2	PF13465
Domain	TPR_8	OGT TTC28 CTR9	2.48e-03	53	95	3	PF13181
Domain	C2H2_Znf_fam	OVOL2 OVOL1	6.57e-03	24	95	2	IPR027775
Domain	ZnF_U1	ZNF407 SNRPC	9.51e-03	29	95	2	SM00451
Domain	Znf_U1	ZNF407 SNRPC	9.51e-03	29	95	2	IPR003604
Domain	SPRY	TRIM22 RYR1 RYR2	9.93e-03	87	95	3	SM00449
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF562 ZNF274 ZNF157 ZNF175 ZNF521 ZNF571 ZNF230 FAS ZNF419 CCNT2 ZNF776 ZNF100 BRD2 CTR9 ZNF382 ZNF253 ZNF506 ZNF614	2.32e-05	1387	63	18	M734
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF562 ZNF274 ZNF419 ZNF776 ZNF100 ZNF728 ZNF253 ZNF614	4.86e-08	181	98	8	37372979
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	BNC2 SP3 ZNF274 ZNF175 ZNF397 OVOL2 ZNF419 JARID2 OVOL1 BRD2 ZNF506 ZNF653 GLIS1	4.56e-07	808	98	13	20412781
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	RNF169 SETX OGT ERCC6 FSIP2 ZNF776 BRD2 PIN4 FEN1 PRDM15 SENP7	1.21e-06	608	98	11	36089195
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RNF169 RTEL1 EXPH5 RNF213 ZNF407 FARP2 ZNF526 CEP152 FGD6 HERPUD1	1.38e-06	493	98	10	15368895
Pubmed	Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma.	OVOL2 OVOL1	7.86e-06	2	98	2	26873447
Pubmed	Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.	RYR1 RYR2	7.86e-06	2	98	2	17259277
Pubmed	Ryanodine receptor oligomeric interaction: identification of a putative binding region.	RYR1 RYR2	7.86e-06	2	98	2	14722100
Pubmed	Structural and functional interactions within ryanodine receptor.	RYR1 RYR2	7.86e-06	2	98	2	26009179
Pubmed	Strain-dependent perinatal lethality of Ovol1-deficient mice and identification of Ovol2 as a downstream target of Ovol1 in skin epidermis.	OVOL2 OVOL1	7.86e-06	2	98	2	17049212
Pubmed	Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.	RYR1 RYR2	7.86e-06	2	98	2	32899693
Pubmed	Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.	RYR1 RYR2	7.86e-06	2	98	2	30542613
Pubmed	Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.	RYR1 RYR2	7.86e-06	2	98	2	15280431
Pubmed	Expression of the ryanodine receptor isoforms in immune cells.	RYR1 RYR2	7.86e-06	2	98	2	11673493
Pubmed	B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.	RYR1 RYR2	7.86e-06	2	98	2	11673462
Pubmed	Senataxin Mutation Reveals How R-Loops Promote Transcription by Blocking DNA Methylation at Gene Promoters.	SETX BAMBI	7.86e-06	2	98	2	29395064
Pubmed	Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes.	APOB OVOL1	7.86e-06	2	98	2	7878058
Pubmed	Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.	RYR1 RYR2	7.86e-06	2	98	2	25370123
Pubmed	Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.	RYR1 RYR2	7.86e-06	2	98	2	15033925
Pubmed	Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.	RYR1 RYR2	7.86e-06	2	98	2	18618700
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SETX OGT TTC28 FARP2 CTR9 XRN1 MARF1 GALNT6 RIOK2 AP3D1	1.55e-05	650	98	10	38777146
Pubmed	Molecular phylogeny of OVOL genes illustrates a conserved C2H2 zinc finger domain coupled by hypervariable unstructured regions.	OVOL2 OVOL1	2.35e-05	3	98	2	22737237
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR2	2.35e-05	3	98	2	18403125
Pubmed	The ovo gene required for cuticle formation and oogenesis in flies is involved in hair formation and spermatogenesis in mice.	OVOL2 OVOL1	2.35e-05	3	98	2	9808631
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR2	2.35e-05	3	98	2	18434746
Pubmed	T cell-derived IFN-γ downregulates protective group 2 innate lymphoid cells in murine lupus erythematosus.	FAS IL33	2.35e-05	3	98	2	29671873
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR2	2.35e-05	3	98	2	9204703
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR2	2.35e-05	3	98	2	7876312
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR2	2.35e-05	3	98	2	21881589
Pubmed	Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.	RYR1 RYR2	2.35e-05	3	98	2	24123915
Pubmed	Exophilin-5 regulates allergic airway inflammation by controlling IL-33-mediated Th2 responses.	EXPH5 IL33	2.35e-05	3	98	2	32240120
Pubmed	Potential role of the OVOL1-OVOL2 axis and c-Myc in the progression of cutaneous squamous cell carcinoma.	OVOL2 OVOL1	2.35e-05	3	98	2	28339425
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR2	2.35e-05	3	98	2	12213830
Pubmed	Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.	RYR1 RYR2	2.35e-05	3	98	2	23278119
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR2	2.35e-05	3	98	2	9242641
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR2	2.35e-05	3	98	2	22948152
Pubmed	Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.	RYR1 RYR2	2.35e-05	3	98	2	23454728
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR2	2.35e-05	3	98	2	10788707
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR2	2.35e-05	3	98	2	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR2	2.35e-05	3	98	2	7621815
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR2	2.35e-05	3	98	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR2	2.35e-05	3	98	2	11159936
Pubmed	Intracellular calcium release channel expression during embryogenesis.	RYR1 RYR2	2.35e-05	3	98	2	9986730
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR2	2.35e-05	3	98	2	10473538
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR2	2.35e-05	3	98	2	7959768
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR2	2.35e-05	3	98	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR2	2.35e-05	3	98	2	7635066
Pubmed	ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation.	ERCC6 BRD2 CTR9 GALNT6	2.40e-05	59	98	4	34108663
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR2	4.70e-05	4	98	2	18206662
Pubmed	Increase of ryanodine receptors by dopamine D1 receptors is negatively regulated by γ-aminobutyric acid type B receptors in primary cultures of mouse cerebral cortical neurons.	RYR1 RYR2	4.70e-05	4	98	2	22504960
Pubmed	Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release.	RYR1 RYR2	4.70e-05	4	98	2	23992453
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR2	4.70e-05	4	98	2	23413940
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR2	4.70e-05	4	98	2	9384575
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR2	4.70e-05	4	98	2	9607712
Pubmed	S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex.	RYR1 RYR2	4.70e-05	4	98	2	27226555
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	RYR1 RYR2	4.70e-05	4	98	2	19120137
Pubmed	FKBP binding characteristics of cardiac microsomes from diverse vertebrates.	RYR1 RYR2	4.70e-05	4	98	2	11237759
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR2	4.70e-05	4	98	2	23482488
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SP3 RNF169 SETX OGT ERCC6 FARP2 JARID2 CELSR1 SHANK2 BRD2 CTR9 STRN4 XRN1 ANKRD11	7.80e-05	1497	98	14	31527615
Pubmed	Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction.	RYR1 RYR2	7.82e-05	5	98	2	22939628
Pubmed	Intracellular calcium-release channels: regulators of cell life and death.	RYR1 RYR2	7.82e-05	5	98	2	9124414
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR1 RYR2	7.82e-05	5	98	2	23918386
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR1 RYR2	7.82e-05	5	98	2	19011160
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR1 RYR2	1.17e-04	6	98	2	19549818
Pubmed	USP2 Inhibits Lung Cancer Pathogenesis by Reducing ARID2 Protein Degradation via Ubiquitination.	RTEL1 CCR8	1.17e-04	6	98	2	36567903
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR1 RYR2	1.17e-04	6	98	2	26025922
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 RYR2	1.17e-04	6	98	2	23463619
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR1 RYR2	1.17e-04	6	98	2	14592808
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 RYR2	1.17e-04	6	98	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 RYR2	1.17e-04	6	98	2	25966694
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR1 RYR2	1.17e-04	6	98	2	19009018
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 RYR2	1.17e-04	6	98	2	16844763
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	RYR2 FSIP2 ADAMTS15 ANKRD11 CLNK	1.17e-04	168	98	5	30631154
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	PDXK FSIP2 TBC1D4 BRD2 PIN4 STRN4 SNRPC	1.40e-04	399	98	7	35987950
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 RYR2	1.64e-04	7	98	2	11860456
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR1 RYR2	1.64e-04	7	98	2	20962236
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR1 RYR2	2.18e-04	8	98	2	19033399
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	RYR1 RYR2	2.18e-04	8	98	2	11784029
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	RYR1 CELSR1 OVOL1 SHANK2 BRD2 STRN4 ANKRD11 BAMBI ZNF614 AP3D1 ANKRD16	2.85e-04	1105	98	11	35748872
Pubmed	A genome-wide association study identifies three new risk loci for Kawasaki disease.	CENPU FAM167A	3.48e-04	10	98	2	22446962
Pubmed	OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-β type I receptor.	OVOL2 OVOL1	3.48e-04	10	98	2	35484112
Pubmed	AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.	RYR1 RYR2	3.48e-04	10	98	2	18434328
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	RNF169 ERCC6 RTEL1 BRD2 CTR9	4.25e-04	222	98	5	37071664
Pubmed	Binding of pRB to the PHD protein RBP2 promotes cellular differentiation.	BNC2 BRD2	4.25e-04	11	98	2	15949438
Pubmed	WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.	TTC28 ANKRD11 ANKRD16	4.34e-04	52	98	3	30655611
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	RYR1 RYR2	5.09e-04	12	98	2	19095005
Pubmed	Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression.	OVOL2 OVOL1	5.09e-04	12	98	2	15716349
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	TTC28 TBC1D4 CTR9 CEP152	5.13e-04	130	98	4	12421765
Pubmed	ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.	APOB RYR1 RYR2	5.68e-04	57	98	3	23788249
Pubmed	High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.	SP3 OGT	6.01e-04	13	98	2	17670746
Pubmed	Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system.	OGT ZNF521 FEZF1	6.61e-04	60	98	3	29055695
Pubmed	MED12 regulates a transcriptional network of calcium-handling genes in the heart.	RYR1 RYR2	7.00e-04	14	98	2	28724790
Pubmed	Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.	GRM4 SHANK2	7.00e-04	14	98	2	21795692
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SETX TTC28 EXPH5 FSIP2 TBC1D4 XRN1 ANKRD11 CEP152 FGD6	7.40e-04	861	98	9	36931259
Pubmed	Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method.	RNF169 RTL5	8.06e-04	15	98	2	12056414
Pubmed	Germline genomic variants associated with childhood acute lymphoblastic leukemia.	ZNF230 RYR2	8.06e-04	15	98	2	19684603
Pubmed	Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy.	ERCC6 FAS	8.06e-04	15	98	2	18854777
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	TTC28 EXPH5 XRN1 SNRPC AP3D1	9.12e-04	263	98	5	34702444
Pubmed	A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.	CELSR1 ANKRD11	9.19e-04	16	98	2	10932191
Pubmed	Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.	RAD51C ERCC6 FEN1	9.52e-04	68	98	3	20496165
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SETX OGT RAE1 ZNF521 CCNT2 BRD2 PIN4 FEN1 SNRPC AP3D1	9.62e-04	1082	98	10	38697112
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF134 ZNF274 ZNF175 ZNF571 ZNF230 RYR1 ZNF419 ZNF776 ZNF526 ZNF382 STRN4 ZNF542P ZNF614 ZNF345	2.52e-07	1192	98	14	chr19q13
Cytoband	Xq13	OGT PIN4	3.46e-04	13	98	2	Xq13
Cytoband	19q13.12	ZNF571 ZNF382 ZNF345	5.06e-04	72	98	3	19q13.12
Cytoband	19q13.43	ZNF419 ZNF776 ZNF542P	8.78e-04	87	98	3	19q13.43
Cytoband	11p15.3	NRIP3 CTR9	9.22e-04	21	98	2	11p15.3
Cytoband	19p12	ZNF100 ZNF728 ZNF66	9.69e-04	90	98	3	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF100 ZNF728 ZNF66	2.32e-03	122	98	3	chr19p12
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	BNC2 ZNF134 SP3 ZFAT ZNF562 ZNF274 ZNF157 ZNF175 ZNF521 ZNF407 ZNF571 ZNF397 ZNF230 ZNF251 OVOL2 ZNF419 ZNF776 ZNF526 OVOL1 ZNF100 FEZF1 ZNF382 ZNF728 ZNF253 ZNF506 ZNF542P PRDM15 ZNF614 ZNF653 GLIS1 ZNF345	5.53e-25	718	71	31	28
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR2	4.55e-05	3	71	2	287
Coexpression	GSE14350_TREG_VS_TEFF_UP	RNF169 OGT RNF213 TBC1D4 ANKRD11 FGD6 PRDM15 HERPUD1	8.41e-07	199	98	8	M3417
Coexpression	GSE2770_UNTREATED_VS_ACT_CD4_TCELL_48H_DN	RNF169 ZNF562 ZNF571 ZNF251 ZNF419 ZNF776 GALNT6	9.15e-06	196	98	7	M6073
Coexpression	GSE3039_ALPHABETA_CD8_TCELL_VS_B1_BCELL_UP	OGT ZNF274 ZNF175 CCNT2 MARF1 PRDM15 FILIP1L	1.04e-05	200	98	7	M6447
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RYR1 MIPOL1 TBC1D4 PIN4 FEN1 CLNK	2.67e-06	179	97	6	9dea57494d59abd6e8abf34e31faf53462ea0fa0
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FAS TBC1D4 BRD2 CES4A CCR8 CLNK	4.77e-06	198	97	6	d021d0edb6aba2f15c51a3ec4e08c7233d0c1962
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BNC2 OGT RNF213 ZNF407 TRIM22 ANKRD11	4.91e-06	199	97	6	f0b0097df0026496470a80d8cc9375ffd8389b00
Disease	aortic valve stenosis (is_marker_for)	OGT JARID2 BAMBI	4.91e-06	11	93	3	DOID:1712 (is_marker_for)
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR2	2.94e-05	3	93	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR2	2.94e-05	3	93	2	DOID:8545 (implicated_via_orthology)
Disease	clonorchiasis (is_marker_for)	FAS IL33	2.94e-05	3	93	2	DOID:13767 (is_marker_for)
Disease	Pilomatrixoma	OVOL2 OVOL1	5.87e-05	4	93	2	C0206711
Disease	Autism Spectrum Disorders	RYR2 JARID2 LRRN3 ANKRD11	1.54e-04	85	93	4	C1510586
Disease	lipoprotein-associated phospholipase A(2) measurement	RNF213 APOB HERPUD1	2.75e-04	40	93	3	EFO_0004746
Disease	level of Phosphatidylcholine (O-18:2_16:0) in blood serum	FEN1 HERPUD1	4.35e-04	10	93	2	OBA_2045132
Disease	phospholipids in very small VLDL measurement	APOB HERPUD1 PMFBP1	5.66e-04	51	93	3	EFO_0022300
Disease	total lipids in medium LDL	APOB FEN1 HERPUD1	5.99e-04	52	93	3	EFO_0022180
Disease	integral membrane protein 2B measurement	APOB HERPUD1	6.35e-04	12	93	2	EFO_0802634
Disease	wet macular degeneration	FGD6 HERPUD1	8.72e-04	14	93	2	EFO_0004683
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	APOB HERPUD1 PMFBP1	9.56e-04	61	93	3	EFO_0008317, EFO_0008596, EFO_0020946
Disease	triglycerides to total lipids in chylomicrons and extremely large VLDL percentage	APOB HERPUD1	1.00e-03	15	93	2	EFO_0022328
Disease	level of Sterol ester (27:1/18:0) in blood serum	FEN1 HERPUD1	1.15e-03	16	93	2	OBA_2045196
Disease	cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	APOB HERPUD1	1.30e-03	17	93	2	EFO_0022232
Disease	very low density lipoprotein cholesterol measurement, esterified cholesterol measurement	APOB HERPUD1	1.45e-03	18	93	2	EFO_0008317, EFO_0008589
Disease	sodium-coupled monocarboxylate transporter 1 measurement	APOB HERPUD1	1.62e-03	19	93	2	EFO_0802076
Disease	serum alanine aminotransferase measurement	EXPH5 APOB ZNF251 JARID2 FEN1 MARF1 CCR8 PMFBP1 SENP7	1.69e-03	869	93	9	EFO_0004735
Disease	mucocutaneous lymph node syndrome	CENPU SHANK2 FAM167A	1.80e-03	76	93	3	EFO_0004246
Disease	sphingomyelin measurement	APOB FEN1 ANKRD11 GALNT6 HERPUD1	1.89e-03	278	93	5	EFO_0010118
Disease	cholesteryl esters to total lipids in chylomicrons and extremely large VLDL percentage	APOB HERPUD1	1.98e-03	21	93	2	EFO_0022246
Disease	Hodgkins lymphoma	ENTHD1 ZNF526 SHANK2	2.24e-03	82	93	3	EFO_0000183
Disease	sphingomyelin 24:1 measurement	ZNF397 CELSR1	2.38e-03	23	93	2	EFO_0010398
Disease	eosinophil percentage of leukocytes	BNC2 ZFAT ENTHD1 FARP2 MIPOL1 CELSR1 SNRPC IL33	2.48e-03	746	93	8	EFO_0007991
Disease	sexual dimorphism measurement	ZFAT APOB GRM4 FARP2 SPTBN5 OVOL1 ANKRD11 SNRPC HERPUD1 AP3D1	2.55e-03	1106	93	10	EFO_0021796
Disease	asthma	RTEL1 CFHR5 GRM4 OVOL1 BRD2 ANKRD11 IL33 SENP7	2.58e-03	751	93	8	MONDO_0004979
Disease	Behcet Syndrome	APOB FAS	2.59e-03	24	93	2	C0004943
Disease	Eczema	BNC2 TTC28 RTEL1 OVOL1 ANKRD16	3.03e-03	310	93	5	HP_0000964
Disease	macular degeneration (is_marker_for)	ERCC6 FAS	3.04e-03	26	93	2	DOID:4448 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QARKLEHVIKVAHAC	CCNT2	96	O60583
KGKLEKCCRHLQHLE	CEP152	1186	O94986
IRKCFGIQQHHKITK	ASB9	266	Q96DX5
HGHLEAVKVLLKRCQ	ANKRD16	181	Q6P6B7
HKHKNKEKGQCSISQ	ANKRD11	636	Q6UB99
DETLGHSKHCRNKQK	TBC1D32	401	Q96NH3
NAVHLKIKHRCTIEG	BNC2	461	Q6ZN30
RHALKKGSHVKKCTN	GRM4	376	Q14833
THLEHQQRIESKVCK	CENPU	261	Q71F23
HCVLNQEVRKHLKGV	CELSR1	2701	Q9NYQ6
KKEKLIRDVAHCHGI	ERCC6	606	Q03468
KGACVERHNLNKHRV	ADAMTS15	501	Q8TE58
IQGHHVCLLVKKGEN	AP3D1	1111	O14617
LKHQHRCVAIFKDKQ	RAE1	211	P78406
CIQHLQLIAEKHKGE	RAD51C	176	O43502
QEKRHVLHLVCNVKS	HERPUD1	76	Q15011
LIKNGSKKVIQHCRE	ENTHD1	81	Q8IYW4
KCKRLEQELHHVKEQ	MIPOL1	276	Q8TD10
IAGFIIKHICQKHLQ	FSIP2	4576	Q5CZC0
NAVKVRHILCEKHGK	PIN4	36	Q9Y237
LKVAKKVAHLAGCNH	CES4A	261	Q5XG92
RGKGKIRHHISCIEK	EXPH5	971	Q8NEV8
QRCSLESHLKKIHGV	OVOL2	186	Q9BRP0
RCSLESHLKKIHGVQ	OVOL1	186	O14753
KDHLGHINECLKVLQ	FAM81B	326	Q96LP2
NLRKNKAGVVIHCNH	SRD5A3	226	Q9H8P0
AKRKHVAEAICKEQH	APOB	251	P04114
VKVTKQHNDECKHLL	FEN1	131	P39748
KTGRKHKRHLVLAAC	IL33	71	O95760
HHSKKGQVAKLDLEC	BAMBI	201	Q13145
ICHLQGDHSVLQKKL	FILIP1L	736	Q4L180
ILHQLKRCQNHNKTK	CCR8	221	P51685
HNIAKQLCLHVSKGA	GALNT6	546	Q8NCL4
GKLQECKQTLLKARH	CTR9	731	Q6PD62
HQLKRCKIAGVNIKT	CFHR5	326	Q9BXR6
IKGHGHKRIVVLKND	MARF1	1546	Q9Y4F3
HSAKEQQVRKKLHAG	GLIS1	346	Q8NBF1
CLEKILEFHQKHVGQ	FARP2	196	O94887
KHGRNHKVLDVLCSL	RYR1	591	P21817
LDKHGRNHKVLDVLC	RYR2	601	Q92736
RHGNLCLDKINVLHK	OGT	526	O15294
QRLACIKKHLKSQGI	JARID2	626	Q92833
GDINKLKIEHTCRLH	FAM167A	146	Q96KS9
CVDRLGLKEHVKSHK	NRIP3	136	Q9NQ35
IKHQHREQGSIKCKL	PMFBP1	591	Q8TBY8
KKQESNHLQIHLCRK	RTEL1	151	Q9NZ71
VAKKAIRKLKQGHCT	RTL5	236	Q5HYW3
VISLDHKNKKHIRGC	SENP7	71	Q9BQF6
RKTHCSGRKHKENVK	SNRPC	21	P09234
KNRKKCVNVTTKGLH	LRRN3	601	Q9H3W5
QKVNMLKHCKRHTGI	PRDM15	1151	P57071
HKIIHTQEKPHKCNQ	FEZF1	306	A0PJY2
NLDGKLHQHVVKCTV	PIP4P2	66	Q8N4L2
EICAKLSHVIKKQHR	SETX	786	Q7Z333
GRKRHCKTKHLEQNG	RNF169	621	Q8NCN4
HKHPNNLKVACEKTV	PDXK	246	O00764
CLNGAQSLHRKHKEL	SPTBN5	1551	Q9NRC6
KTNLKKCMDHIQHRL	SHANK2	161	Q9UPX8
KHCNGILKELLSKKH	BRD2	351	P25440
DGKDKTGVHRKQCHL	CLNK	401	Q7Z7G1
IHVLKALNRCQLKHT	RNF213	5061	Q63HN8
NVIHQKGCFHKLLKI	TSPAN16	196	Q9UKR8
KVHKEHDNKLNQCLI	ZNF100	156	Q8IYN0
HLKQCVAVHTGKKSE	ZNF562	246	Q6V9R5
NHVNLVHRKGKTKVC	ZNF653	486	Q96CK0
MQLTLHKRNHTQKKC	ZNF542P	111	Q5EBM4
KRHVIQKHSNILLKC	ZFAT	786	Q9P243
KKSLCQHRRTHTGEK	ZNF157	426	P51786
QGLLKVLHKQCHHKR	ROPN1L	76	Q96C74
QKTCRKHRKENQGSH	FAS	196	P25445
RGTNLGKKKQHICHI	SP3	611	Q02447
VKHNHLENQGKVHKC	ZNF521	771	Q96K83
KHNSRVKIHQKSCER	ZNF274	461	Q96GC6
CIHKLGHRENLCVKQ	FGD6	116	Q6ZV73
KCSNSKRHKIRHTGK	ZNF728	156	P0DKX0
CNHSLKKEERKRNQH	XRN1	581	Q8IZH2
HGGCNKVLRELVKHK	RIOK2	46	Q9BVS4
LHLRQLCEAKQKTHV	TBC1D4	516	O60343
QLKKGCKSVGEHKVH	ZNF253	111	O75346
CHEQHLKIAKDLGNK	TTC28	376	Q96AY4
QHQKVHSGETRKCRK	ZNF251	506	Q9BRH9
LIRHRKIHTGEKACK	ZNF397	356	Q8NF99
RAILQVHCKLHTGEK	ZNF230	236	Q9UIE0
QKLILRRHKKCGHDN	ZNF66	96	Q6ZN08
RRHKKCGHDNLQLKK	ZNF66	101	Q6ZN08
VCGKGFKKLIHVRNH	ZNF526	476	Q8TF50
KTCVQEITAHRKKHE	STRN4	711	Q9NRL3
QHKKSHNGKKLCELE	ZNF345	471	Q14585
RHCATKKHKGRVEIE	ZNF407	896	Q9C0G0
KELCLNHKRAEIQGK	WHAMMP3	81	Q1A5X7
QKICLIQHERCHTGK	ZNF614	466	Q8N883
CKSNLIVHQKTHKVE	ZNF382	531	Q96SR6
QHQKQHCGEKPLKRQ	ZNF419	126	Q96HQ0
GQKRDVCEHHGKKLQ	TRIM22	91	Q8IYM9
HNIEKCSEVKKHRNT	ZNF571	161	Q7Z3V5
GGCQQKAIHSKRKTH	ZNF134	146	P52741
ALNKHKKIHIRQKPC	ZNF506	411	Q5JVG8
QCRKVCGHKQSLKQH	ZNF175	256	Q9Y473
CFRQKGNLIKHQRVH	ZNF776	496	Q68DI1