Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	NLS-bearing protein import into nucleus	RGPD8 RGPD1 RGPD5	8.12e-06	20	41	3	GO:0006607
GeneOntologyBiologicalProcess	protein import into nucleus	RGPD8 RGPD1 NUP188 SIX2 RGPD5	4.08e-05	195	41	5	GO:0006606
GeneOntologyBiologicalProcess	import into nucleus	RGPD8 RGPD1 NUP188 SIX2 RGPD5	4.71e-05	201	41	5	GO:0051170
GeneOntologyBiologicalProcess	establishment of protein localization to organelle	RGPD8 SREBF1 RGPD1 NUP188 SIX2 SORL1 RGPD5	6.25e-05	515	41	7	GO:0072594
GeneOntologyBiologicalProcess	regulation of animal organ morphogenesis	SP6 SIX1 SIX2 PTK7	6.66e-05	110	41	4	GO:2000027
GeneOntologyBiologicalProcess	protein localization to nucleus	RGPD8 RGPD1 NUP188 SIX1 SIX2 RGPD5	7.50e-05	362	41	6	GO:0034504
GeneOntologyBiologicalProcess	embryonic organ development	HSPG2 LPA PRICKLE2 PKDCC SIX1 SIX2 PTK7	1.07e-04	561	41	7	GO:0048568
GeneOntologyBiologicalProcess	positive regulation of glucokinase activity	RGPD8 RGPD1	1.38e-04	9	41	2	GO:0033133
GeneOntologyBiologicalProcess	chondrocyte differentiation	HSPG2 CHRDL2 PKDCC SIX2	1.39e-04	133	41	4	GO:0002062
GeneOntologyBiologicalProcess	positive regulation of hexokinase activity	RGPD8 RGPD1	1.72e-04	10	41	2	GO:1903301
GeneOntologyBiologicalProcess	mRNA transport	RGPD8 RGPD1 NPIPA1 NUP188	1.94e-04	145	41	4	GO:0051028
GeneOntologyBiologicalProcess	regulation of glucokinase activity	RGPD8 RGPD1	2.97e-04	13	41	2	GO:0033131
GeneOntologyBiologicalProcess	cardioblast proliferation	PIM1 SIX1	2.97e-04	13	41	2	GO:0003263
GeneOntologyBiologicalProcess	regulation of cardioblast proliferation	PIM1 SIX1	2.97e-04	13	41	2	GO:0003264
GeneOntologyBiologicalProcess	regulation of hexokinase activity	RGPD8 RGPD1	3.46e-04	14	41	2	GO:1903299
GeneOntologyBiologicalProcess	RNA transport	RGPD8 RGPD1 NPIPA1 NUP188	3.97e-04	175	41	4	GO:0050658
GeneOntologyBiologicalProcess	nucleic acid transport	RGPD8 RGPD1 NPIPA1 NUP188	3.97e-04	175	41	4	GO:0050657
GeneOntologyBiologicalProcess	establishment of RNA localization	RGPD8 RGPD1 NPIPA1 NUP188	4.23e-04	178	41	4	GO:0051236
GeneOntologyBiologicalProcess	kidney mesenchyme development	SIX1 SIX2	4.55e-04	16	41	2	GO:0072074
GeneOntologyBiologicalProcess	maintenance of postsynaptic specialization structure	PRICKLE2 SYNGAP1	5.14e-04	17	41	2	GO:0098880
GeneOntologyBiologicalProcess	connective tissue development	HSPG2 CHRDL2 PKDCC SIX2 SORL1	5.66e-04	343	41	5	GO:0061448
GeneOntologyBiologicalProcess	positive regulation of brown fat cell differentiation	PIM1 SIX1	5.78e-04	18	41	2	GO:0090336
GeneOntologyBiologicalProcess	negative regulation of triglyceride metabolic process	SREBF1 SORL1	7.16e-04	20	41	2	GO:0090209
GeneOntologyBiologicalProcess	regulation of cell proliferation involved in heart morphogenesis	PIM1 SIX1	7.90e-04	21	41	2	GO:2000136
GeneOntologyBiologicalProcess	negative regulation of cell adhesion	HSPG2 PTPN6 ZNF608 LPA JAM3	8.46e-04	375	41	5	GO:0007162
GeneOntologyBiologicalProcess	nuclear transport	RGPD8 RGPD1 NUP188 SIX2 RGPD5	8.77e-04	378	41	5	GO:0051169
GeneOntologyBiologicalProcess	nucleocytoplasmic transport	RGPD8 RGPD1 NUP188 SIX2 RGPD5	8.77e-04	378	41	5	GO:0006913
GeneOntologyBiologicalProcess	RNA localization	RGPD8 RGPD1 NPIPA1 NUP188	8.89e-04	217	41	4	GO:0006403
GeneOntologyBiologicalProcess	cell proliferation involved in heart morphogenesis	PIM1 SIX1	9.50e-04	23	41	2	GO:0061323
GeneOntologyCellularComponent	nuclear pore	RGPD8 RGPD1 NPIPA1 NUP188 RGPD5	3.11e-06	101	47	5	GO:0005643
GeneOntologyCellularComponent	nuclear envelope	RGPD8 SREBF1 RGPD1 PRICKLE2 NPIPA1 NPIPB3 NUP188 SORL1 RGPD5	3.66e-06	560	47	9	GO:0005635
GeneOntologyCellularComponent	cytoplasmic periphery of the nuclear pore complex	RGPD8 RGPD1	1.37e-04	8	47	2	GO:1990723
GeneOntologyCellularComponent	nuclear pore cytoplasmic filaments	RGPD8 RGPD1	2.20e-04	10	47	2	GO:0044614
GeneOntologyCellularComponent	annulate lamellae	RGPD8 RGPD1	4.43e-04	14	47	2	GO:0005642
GeneOntologyCellularComponent	nuclear pore nuclear basket	RGPD8 RGPD1	7.40e-04	18	47	2	GO:0044615
GeneOntologyCellularComponent	nuclear inclusion body	RGPD8 RGPD1	9.16e-04	20	47	2	GO:0042405
GeneOntologyCellularComponent	SUMO ligase complex	RGPD8 RGPD1	1.01e-03	21	47	2	GO:0106068
MousePheno	abnormal respiratory system morphology	HSPG2 PTPN6 RGPD8 MOGS LPA RGPD1 SP6 PKDCC SIX1 TRAPPC9 PTK7	1.37e-05	1027	33	11	MP:0002132
MousePheno	bradykinesia	SIX1 BAHCC1 SYNGAP1	9.56e-05	38	33	3	MP:0005156
MousePheno	increased acute phase protein level	PTPN6 LPA	1.13e-04	7	33	2	MP:0014499
MousePheno	increased diameter of humerus	HSPG2 PKDCC	1.13e-04	7	33	2	MP:0008160
Domain	NPIP	NPIPB13 NPIPA5 NPIPA1 NPIPB3 NPIPA3 NPIPB5 NPIPA7 NPIPA2 NPIPB2	4.37e-21	14	48	9	IPR009443
Domain	PIM1/2/3	PIM3 PIM2 PIM1	1.59e-08	3	48	3	IPR017348
Domain	GRIP	RGPD8 RGPD1 RGPD5	2.59e-06	11	48	3	PF01465
Domain	Grip	RGPD8 RGPD1 RGPD5	2.59e-06	11	48	3	SM00755
Domain	Ran_BP1	RGPD8 RGPD1 RGPD5	3.45e-06	12	48	3	PF00638
Domain	GRIP_dom	RGPD8 RGPD1 RGPD5	3.45e-06	12	48	3	IPR000237
Domain	GRIP	RGPD8 RGPD1 RGPD5	3.45e-06	12	48	3	PS50913
Domain	RANBD1	RGPD8 RGPD1 RGPD5	3.45e-06	12	48	3	PS50196
Domain	RanBD	RGPD8 RGPD1 RGPD5	4.47e-06	13	48	3	SM00160
Domain	Ran_bind_dom	RGPD8 RGPD1 RGPD5	4.47e-06	13	48	3	IPR000156
Domain	SIX1_SD	SIX1 SIX2	1.35e-04	7	48	2	PF16878
Domain	GCC2_Rab_bind	RGPD8 RGPD1	1.35e-04	7	48	2	IPR032023
Domain	Rab_bind	RGPD8 RGPD1	1.35e-04	7	48	2	PF16704
Domain	SIX1_SD	SIX1 SIX2	1.35e-04	7	48	2	IPR031701
Domain	-	RGPD8 RGPD1	2.87e-04	10	48	2	1.10.220.60
Domain	TPR_1	RGPD8 RGPD1 RGPD5	1.60e-03	90	48	3	PF00515
Domain	TPR_1	RGPD8 RGPD1 RGPD5	1.60e-03	90	48	3	IPR001440
Domain	Kringle-like	LPA LY75	3.05e-03	32	48	2	IPR013806
Domain	LDLR_class-A_CS	HSPG2 SORL1	4.74e-03	40	48	2	IPR023415
Domain	Ldl_recept_a	HSPG2 SORL1	5.97e-03	45	48	2	PF00057
Domain	-	HSPG2 SORL1	6.23e-03	46	48	2	4.10.400.10
Domain	TPR-contain_dom	RGPD8 RGPD1 RGPD5	6.74e-03	150	48	3	IPR013026
Domain	LDLRA_1	HSPG2 SORL1	6.77e-03	48	48	2	PS01209
Domain	LDrepeatLR_classA_rpt	HSPG2 SORL1	7.04e-03	49	48	2	IPR002172
Domain	LDLa	HSPG2 SORL1	7.04e-03	49	48	2	SM00192
Domain	LDLRA_2	HSPG2 SORL1	7.04e-03	49	48	2	PS50068
Domain	Prot_kinase_dom	PIM3 PIM2 PIM1 PKDCC PTK7	8.18e-03	489	48	5	IPR000719
Domain	PROTEIN_KINASE_DOM	PIM3 PIM2 PIM1 PKDCC PTK7	8.45e-03	493	48	5	PS50011
Domain	TPR	RGPD8 RGPD1 RGPD5	8.75e-03	165	48	3	PS50005
Domain	TPR_REGION	RGPD8 RGPD1 RGPD5	8.75e-03	165	48	3	PS50293
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_JAK_STAT_SIGNALING_PATHWAY	PIM2 PIM1	4.36e-05	5	30	2	M48986
Pathway	REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY	RGPD8 RGPD1 NUP188	8.15e-05	40	30	3	MM14945
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS	RGPD8 RGPD1 NUP188	8.78e-05	41	30	3	MM15200
Pathway	REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS	RGPD8 RGPD1 NUP188	9.44e-05	42	30	3	MM15039
Pathway	REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA	RGPD8 RGPD1 NUP188	1.01e-04	43	30	3	MM14609
Pathway	REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS	RGPD8 RGPD1 NUP188	1.32e-04	47	30	3	MM14939
Pathway	REACTOME_GENE_SILENCING_BY_RNA	RGPD8 RGPD1 NUP188	1.50e-04	49	30	3	MM14837
Pathway	REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS	RGPD8 RGPD1 NUP188	1.59e-04	50	30	3	MM14610
Pathway	REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS	RGPD8 RGPD1 NUP188	1.69e-04	51	30	3	MM15151
Pathway	REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN	RGPD8 RGPD1 NUP188	2.12e-04	55	30	3	MM14917
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	RGPD8 RGPD1 NUP188	2.48e-04	58	30	3	MM15149
Pathway	REACTOME_SNRNP_ASSEMBLY	RGPD8 RGPD1 NUP188	2.48e-04	58	30	3	MM14736
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	RGPD8 RGPD1 NUP188	3.48e-04	65	30	3	MM15147
Pathway	REACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE	RGPD8 RGPD1 NUP188	4.89e-04	73	30	3	MM14948
Pathway	BIOCARTA_RANBP2_PATHWAY	RGPD8 RGPD1	6.56e-04	18	30	2	MM1549
Pathway	REACTOME_GLUCOSE_METABOLISM	RGPD8 RGPD1 NUP188	6.88e-04	82	30	3	MM15394
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	RGPD8 RGPD1 NUP188	7.38e-04	84	30	3	MM14929
Pathway	REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM	RGPD8 RGPD1 NUP188	7.90e-04	86	30	3	MM15413
Pathway	WP_IMATINIB_AND_CHRONIC_MYELOID_LEUKEMIA	PIM2 PIM1	8.12e-04	20	30	2	M39381
Pathway	REACTOME_FORMATION_OF_THE_URETERIC_BUD	SIX1 SIX2	8.97e-04	21	30	2	M48244
Pathway	REACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS	RGPD8 RGPD1 NUP188	9.61e-04	92	30	3	MM14951
Pathway	REACTOME_MITOTIC_PROPHASE	RGPD8 RGPD1 NUP188	1.78e-03	114	30	3	MM15361
Pathway	REACTOME_METABOLISM_OF_CARBOHYDRATES	RGPD8 CHST14 RGPD1 NUP188	2.47e-03	271	30	4	MM15406
Pubmed	Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling.	NPIPA5 NPIPA1 NPIPA3 NPIPA2	4.80e-12	4	53	4	18055785
Pubmed	A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.	PIM3 PIM2 PIM1	3.34e-09	3	53	3	19965690
Pubmed	Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells.	PIM3 PIM2 PIM1	3.34e-09	3	53	3	23495171
Pubmed	Developmental expression of pim kinases suggests functions also outside of the hematopoietic system.	PIM3 PIM2 PIM1	3.34e-09	3	53	3	10713710
Pubmed	Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene.	PIM3 PIM2 PIM1	3.34e-09	3	53	3	18042805
Pubmed	Patterns and Significance of PIM Kinases in Urothelial Carcinoma.	PIM3 PIM2 PIM1	3.34e-09	3	53	3	26551340
Pubmed	The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.	PIM3 PIM2 PIM1	3.34e-09	3	53	3	25238262
Pubmed	Expression of PIM kinases in Reed-Sternberg cells fosters immune privilege and tumor cell survival in Hodgkin lymphoma.	PIM3 PIM2 PIM1	3.34e-09	3	53	3	28698206
Pubmed	The essential role of PIM kinases in sarcoma growth and bone invasion.	PIM3 PIM2 PIM1	3.34e-09	3	53	3	22623646
Pubmed	Pim kinase inhibitors sensitize prostate cancer cells to apoptosis triggered by Bcl-2 family inhibitor ABT-737.	PIM3 PIM2 PIM1	3.34e-09	3	53	3	22080570
Pubmed	PIM kinases: an overview in tumors and recent advances in pancreatic cancer.	PIM3 PIM2 PIM1	3.34e-09	3	53	3	24799066
Pubmed	Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation.	PIM3 PIM2 PIM1	3.34e-09	3	53	3	23209281
Pubmed	Metabolic dysfunction consistent with premature aging results from deletion of Pim kinases.	PIM3 PIM2 PIM1	3.34e-09	3	53	3	24916111
Pubmed	Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice.	PIM3 PIM2 PIM1	3.34e-09	3	53	3	23360755
Pubmed	Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors.	PIM3 PIM2 PIM1	3.34e-09	3	53	3	15199164
Pubmed	PIM kinases as therapeutic targets against advanced melanoma.	PIM3 PIM2 PIM1	3.34e-09	3	53	3	27448973
Pubmed	Fighting tumor cell survival: advances in the design and evaluation of Pim inhibitors.	PIM3 PIM2 PIM1	3.34e-09	3	53	3	20939820
Pubmed	PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity.	PIM3 PIM2 PIM1	3.34e-09	3	53	3	29781812
Pubmed	PIM1 Promotes Survival of Cardiomyocytes by Upregulating c-Kit Protein Expression.	PIM3 PIM2 PIM1	1.34e-08	4	53	3	32878131
Pubmed	PIM kinases 1, 2 and 3 in intracellular LIF signaling, proliferation and apoptosis in trophoblastic cells.	PIM3 PIM2 PIM1	1.34e-08	4	53	3	28729093
Pubmed	Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL.	PIM3 PIM2 PIM1	3.33e-08	5	53	3	16403219
Pubmed	The Pim protein kinases regulate energy metabolism and cell growth.	PIM3 PIM2 PIM1	3.33e-08	5	53	3	21187426
Pubmed	Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.	PIM3 PIM2 PIM1	6.66e-08	6	53	3	18593906
Pubmed	Complex genomic rearrangements lead to novel primate gene function.	RGPD8 RGPD1 RGPD5	1.16e-07	7	53	3	15710750
Pubmed	Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc.	PIM2 PIM1	2.28e-06	2	53	2	9294606
Pubmed	The role of PIM1/PIM2 kinases in tumors of the male reproductive system.	PIM2 PIM1	2.28e-06	2	53	2	27901106
Pubmed	Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration.	PIM2 PIM1	2.28e-06	2	53	2	19687226
Pubmed	PIM-2 is an independent regulator of chondrocyte survival and autophagy in the epiphyseal growth plate.	PIM2 PIM1	2.28e-06	2	53	2	17476689
Pubmed	Microenvironment-induced PIM kinases promote CXCR4-triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration.	PIM2 PIM1	2.28e-06	2	53	2	29665227
Pubmed	Analysis of the mutational status of SIX1/2 and microRNA processing genes in paired primary and relapsed Wilms tumors and association with relapse.	SIX1 SIX2	2.28e-06	2	53	2	33281191
Pubmed	Positive selection of a gene family during the emergence of humans and African apes.	NPIPA1 NPIPA8	2.28e-06	2	53	2	11586358
Pubmed	Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity.	PIM2 PIM1	2.28e-06	2	53	2	15721354
Pubmed	Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts.	PIM3 PIM1	2.28e-06	2	53	2	26075720
Pubmed	Self-renewal of murine embryonic stem cells is supported by the serine/threonine kinases Pim-1 and Pim-3.	PIM3 PIM1	2.28e-06	2	53	2	17717068
Pubmed	The Pim kinases control rapamycin-resistant T cell survival and activation.	PIM2 PIM1	2.28e-06	2	53	2	15642745
Pubmed	KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA.	PIM3 PIM1	2.28e-06	2	53	2	19266083
Pubmed	Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival.	PIM2 PIM1	6.83e-06	3	53	2	15705789
Pubmed	Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss.	SIX1 SIX2	6.83e-06	3	53	2	15735644
Pubmed	Pim kinase-dependent inhibition of c-Myc degradation.	PIM2 PIM1	6.83e-06	3	53	2	18438430
Pubmed	High Expression of NEK2 and PIM1, but Not PIM3, Is Linked to an Aggressive Phenotype of Bronchopulmonary Neuroendocrine Neoplasms.	PIM3 PIM1	6.83e-06	3	53	2	32504181
Pubmed	Divergent origins and concerted expansion of two segmental duplications on chromosome 16.	NPIPB3 NPIPB5	6.83e-06	3	53	2	11948212
Pubmed	PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation.	PIM3 PIM1	6.83e-06	3	53	2	31015445
Pubmed	Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2.	PIM2 PIM1	6.83e-06	3	53	2	7781606
Pubmed	Pim serine/threonine kinases regulate the stability of Socs-1 protein.	PIM2 PIM1	6.83e-06	3	53	2	11854514
Pubmed	Stabilization of PIM Kinases in Hypoxia Is Mediated by the Deubiquitinase USP28.	PIM2 PIM1	6.83e-06	3	53	2	35326457
Pubmed	Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome.	SIX1 SIX2	6.83e-06	3	53	2	11734542
Pubmed	Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma.	PIM2 PIM1	6.83e-06	3	53	2	21859846
Pubmed	PI3K-like kinases restrain Pim gene expression in endothelial cells.	PIM3 PIM1	6.83e-06	3	53	2	22282239
Pubmed	Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors.	SIX1 SIX2	1.36e-05	4	53	2	25670082
Pubmed	Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity.	HSPG2 PTPN6	1.36e-05	4	53	2	19789387
Pubmed	eIF4B phosphorylation by pim kinases plays a critical role in cellular transformation by Abl oncogenes.	PIM2 PIM1	1.36e-05	4	53	2	23749639
Pubmed	RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation.	PIM2 PIM1	1.36e-05	4	53	2	22201128
Pubmed	The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes.	PIM2 PIM1	1.36e-05	4	53	2	18216297
Pubmed	Zinc finger protein GFI-1 cooperates with myc and pim-1 in T-cell lymphomagenesis by reducing the requirements for IL-2.	PIM2 PIM1	1.36e-05	4	53	2	8622900
Pubmed	Six family genes control the proliferation and differentiation of muscle satellite cells.	SIX1 SIX2	1.36e-05	4	53	2	20696153
Pubmed	Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators.	SIX1 SIX2	1.36e-05	4	53	2	26884396
Pubmed	Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.	RGPD8 RGPD5	1.36e-05	4	53	2	9480752
Pubmed	A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB.	SIX1 SIX2	1.36e-05	4	53	2	30894749
Pubmed	Identification and characterization of collaborating oncogenes in compound mutant mice.	PIM2 PIM1	1.36e-05	4	53	2	10197595
Pubmed	Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors.	SIX1 SIX2	2.27e-05	5	53	2	25670083
Pubmed	Six1 and Six2 of the Sine Oculis Homeobox Subfamily are Not Functionally Interchangeable in Mouse Nephron Formation.	SIX1 SIX2	2.27e-05	5	53	2	35178390
Pubmed	Tissue and developmental distribution of Six family gene products.	SIX1 SIX2	2.27e-05	5	53	2	9551859
Pubmed	Characterization of the cDNA coding for mouse plasminogen and localization of the gene to mouse chromosome 17.	PIM1 LPA	2.27e-05	5	53	2	2081600
Pubmed	The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells.	PTPN6 SYNGAP1	2.27e-05	5	53	2	9405464
Pubmed	Identification and expression of six family genes in mouse retina.	SIX1 SIX2	2.27e-05	5	53	2	8814301
Pubmed	Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders.	SIX1 SIX2	2.27e-05	5	53	2	26034287
Pubmed	Peering through the pore: nuclear pore complex structure, assembly, and function.	RGPD8 RGPD1 NUP188	2.71e-05	38	53	3	12791264
Pubmed	Association of gene polymorphisms with chronic kidney disease in Japanese individuals.	LARGE2 PCSK2 TRAPPC9	2.94e-05	39	53	3	19724895
Pubmed	Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site.	SIX1 SIX2	3.40e-05	6	53	2	9826681
Pubmed	Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival.	PIM2 PIM1	3.40e-05	6	53	2	17942753
Pubmed	14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF).	PIM3 PIM1	3.40e-05	6	53	2	19166854
Pubmed	Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis.	SIX1 SIX2	3.40e-05	6	53	2	20074369
Pubmed	The expression profile and clinic significance of the SIX family in non-small cell lung cancer.	SIX1 SIX2	3.40e-05	6	53	2	27821176
Pubmed	Dynamic expression of Six family genes in the dental mesenchyme and the epithelial ameloblast stem/progenitor cells during murine tooth development.	SIX1 SIX2	3.40e-05	6	53	2	19900183
Pubmed	Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.	RGPD8 RGPD1	4.76e-05	7	53	2	30944974
Pubmed	Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.	RGPD8 RGPD1	4.76e-05	7	53	2	38838144
Pubmed	Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.	RGPD8 RGPD1	4.76e-05	7	53	2	21205196
Pubmed	Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.	RGPD8 RGPD1	4.76e-05	7	53	2	18949001
Pubmed	Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.	RGPD8 RGPD1	4.76e-05	7	53	2	25187515
Pubmed	Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.	RGPD8 RGPD1	4.76e-05	7	53	2	9037092
Pubmed	Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.	RGPD8 RGPD1	4.76e-05	7	53	2	23536549
Pubmed	Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.	RGPD8 RGPD1	4.76e-05	7	53	2	8603673
Pubmed	Retina-specifically expressed novel subtypes of bovine cyclophilin.	RGPD8 RGPD1	4.76e-05	7	53	2	7559465
Pubmed	Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).	RGPD8 RGPD1	4.76e-05	7	53	2	26632511
Pubmed	Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.	RGPD8 RGPD1	4.76e-05	7	53	2	17372272
Pubmed	Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.	RGPD8 RGPD1	4.76e-05	7	53	2	24403063
Pubmed	Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.	RGPD8 RGPD1	4.76e-05	7	53	2	23818861
Pubmed	Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.	RGPD8 RGPD1	4.76e-05	7	53	2	38657106
Pubmed	Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.	RGPD8 RGPD1	4.76e-05	7	53	2	11353387
Pubmed	Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein.	SIX1 SIX2	4.76e-05	7	53	2	12215533
Pubmed	Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base.	SIX1 SIX2	4.76e-05	7	53	2	20515681
Pubmed	Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.	RGPD8 RGPD1	4.76e-05	7	53	2	12191015
Pubmed	Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	RGPD8 RGPD1	4.76e-05	7	53	2	22821000
Pubmed	Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.	RGPD8 RGPD1	4.76e-05	7	53	2	20682751
Pubmed	The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.	RGPD8 RGPD1	6.34e-05	8	53	2	22262462
Pubmed	Six3 and Six6 activity is modulated by members of the groucho family.	SIX1 SIX2	6.34e-05	8	53	2	12441302
Pubmed	Lmx1b expression during joint and tendon formation: localization and evaluation of potential downstream targets.	SIX1 SIX2	6.34e-05	8	53	2	15183306
Pubmed	Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme.	SIX1 SIX2	6.34e-05	8	53	2	15634706
Pubmed	The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.	RGPD8 RGPD1	6.34e-05	8	53	2	21670213
Pubmed	Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.	RGPD8 RGPD1	6.34e-05	8	53	2	28745977
Interaction	NPIPB6 interactions	RGPD8 RGPD1 RGPD5	8.87e-06	18	46	3	int:NPIPB6
Interaction	RGPD4 interactions	RGPD8 RGPD1 RGPD5	1.66e-05	22	46	3	int:RGPD4
Interaction	RGPD2 interactions	RGPD8 RGPD1 RGPD5	3.13e-05	27	46	3	int:RGPD2
Cytoband	16p13.11	NPIPA5 NPIPA1 NPIPA3 NPIPA2	1.38e-08	23	53	4	16p13.11
Cytoband	Ensembl 112 genes in cytogenetic band chr16p13	NPIPA5 NPIPA1 NPIPA3 NPIPA7 NPIPA2 NPIPB2	9.79e-06	426	53	6	chr16p13
Cytoband	16p12.2	NPIPB4 NPIPB3 NPIPB5	1.10e-05	37	53	3	16p12.2
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	NPIPB4 NPIPB3 NPIPB5 NPIPA8	4.83e-05	172	53	4	chr16p12
Cytoband	2p13.1	MOGS DUSP11	7.16e-04	34	53	2	2p13.1
Cytoband	16p11.2	NPIPB13 NPIPB12 NPIPB11	1.42e-03	191	53	3	16p11.2
Cytoband	2p21	PKDCC SIX2	2.29e-03	61	53	2	2p21
Cytoband	2q13	RGPD8 RGPD5	2.84e-03	68	53	2	2q13
Cytoband	Ensembl 112 genes in cytogenetic band chr2p21	PKDCC SIX2	3.90e-03	80	53	2	chr2p21
Cytoband	Ensembl 112 genes in cytogenetic band chr16p11	NPIPB13 NPIPB12 NPIPB11	4.12e-03	278	53	3	chr16p11
Cytoband	11p11.2	LARGE2 ALKBH3	4.19e-03	83	53	2	11p11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr2p13	MOGS DUSP11	1.15e-02	140	53	2	chr2p13
Cytoband	Ensembl 112 genes in cytogenetic band chr11p11	LARGE2 ALKBH3	1.36e-02	153	53	2	chr11p11
GeneFamily	SINE class homeoboxes	SIX1 SIX2	3.71e-05	6	29	2	525
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RGPD8 RGPD1 RGPD5	8.12e-04	115	29	3	769
GeneFamily	Immunoglobulin like domain containing	HSPG2 JAM3 PTK7	3.57e-03	193	29	3	594
GeneFamily	Actins\|Deafness associated genes	ILDR1 SIX1	1.41e-02	113	29	2	1152
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NPIPB4 RGPD8 NPIPB3 NPIPB5 TRAPPC9	3.35e-06	193	53	5	779276e775cb2492e8dd36436295a536084a6415
ToppCell	Biopsy_IPF-Epithelial-Transitional_AT2\|Biopsy_IPF / Sample group, Lineage and Cell type	PCSK2 HSPG2 CYP4B1 PKDCC PTK7	3.89e-06	199	53	5	83ff8b7e472d1212324c05cc719b746d19e5e23b
ToppCell	COVID-19_Mild-Neu_4\|World / 5 Neutrophil clusters in COVID-19 patients	NPIPA5 NPIPA2 CRISPLD1 NPIPA8	1.45e-05	124	53	4	5ef9eb806fb2c8ee5aae0a75503d244b08ee10d4
ToppCell	ICU-SEP-Lymphocyte-T_NK-Treg\|ICU-SEP / Disease, Lineage and Cell Type	PIM2 RGPD1 SARDH RGPD5	2.68e-05	145	53	4	ee99b58462f955b96d036aa67e343db047d66f64
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CHRDL2 SP6 NPIPA3 SIX1	3.39e-05	154	53	4	30cb4bb297fa815adb829f3b5cafca56fcbcb810
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CHRDL2 SP6 NPIPA3 SIX1	3.39e-05	154	53	4	ade094e2947761a0a34daa8fcff3e9ea8437e4a5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CHRDL2 SP6 NPIPA3 SIX1	3.39e-05	154	53	4	42bd8f88fd075a2d4edde394785decad88a2660a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CHRDL2 SP6 NPIPA3 SIX1	3.39e-05	154	53	4	6425d9861148586466febd6eceae1b1f9b9a14c1
ToppCell	367C-Fibroblasts-Fibroblast-G-\|367C / Donor, Lineage, Cell class and subclass (all cells)	PCSK2 NPIPA5 PRICKLE2 NPIPA3	4.76e-05	168	53	4	b8c65542a0701ae31f49d332d87a64578e24b4e3
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Lymphocytic-T_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIM2 SARDH LY75 SORL1	4.76e-05	168	53	4	182f08106ac65ea501e2fb9139d3b44b7c4662c9
ToppCell	367C-Fibroblasts-Fibroblast-G\|367C / Donor, Lineage, Cell class and subclass (all cells)	PCSK2 NPIPA5 PRICKLE2 NPIPA3	4.76e-05	168	53	4	8c95093b1ea45826f62893edd3c410fe53b563a4
ToppCell	356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|356C / Donor, Lineage, Cell class and subclass (all cells)	CYP4B1 FAM181A ILDR1 SIX1	5.58e-05	175	53	4	4bfae78ac3a2cb9404382aae96d291504a9cfa14
ToppCell	356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	CYP4B1 FAM181A ILDR1 SIX1	5.58e-05	175	53	4	af9c5104c86231cfdb93a0f7d7032379efaa009e
ToppCell	wk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	PCSK2 HSPG2 NPIPA5 CRISPLD1	5.71e-05	176	53	4	52af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCell	Children_(3_yrs)-Epithelial-basal_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CYP4B1 LPA PRICKLE2 JAM3	5.96e-05	178	53	4	fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCell	390C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|390C / Donor, Lineage, Cell class and subclass (all cells)	CYP4B1 FAM181A ILDR1 SIX1	5.96e-05	178	53	4	fce60ce6b662f1bdaa3b4da43800c6c22fe89533
ToppCell	390C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	CYP4B1 FAM181A ILDR1 SIX1	5.96e-05	178	53	4	b19c906e067b07eadfd68934d9330b447e24c708
ToppCell	facs-Brain_Non-Myeloid-Striatum_\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LARGE2 PTPN6 CYP4B1 ILDR1	6.64e-05	183	53	4	824ecda1219fb596a01bf5cfeee29a6daa462098
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LARGE2 PTPN6 CYP4B1 ILDR1	6.64e-05	183	53	4	82b84ee065fb573688d59da97a327152a1ba294c
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D175\|Adult / Lineage, Cell type, age group and donor	ZNF608 SP6 PRICKLE2 JAM3	7.22e-05	187	53	4	f3548817f2fded5978137bb252cb628ac199e4f6
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HSPG2 ZNF608 CYP4B1 PKDCC	7.22e-05	187	53	4	4ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP4B1 PIM1 FAM181A JAM3	7.83e-05	191	53	4	4180521a8c5e0ad629cacdd22dc6a94e94b28816
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-basal_intermediate_\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CYP4B1 FAM181A SIX1 SIX2	8.15e-05	193	53	4	83d2dd823808a2b5ca1a6889eefb541ec042b24c
ToppCell	nucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-CD4_T\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NPIPB4 PIM2 NPIPB3 NPIPB5	8.15e-05	193	53	4	9c9434a3297b85774b4f0ecab6294f44d738e29f
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF608 CHST14 CYP4B1 PRICKLE2	8.65e-05	196	53	4	ed76eeb37400ca154feae9b7ebaddb6c434f8b81
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF608 CYP4B1 SIX1 SIX2	8.65e-05	196	53	4	7e19919eafd6ddf547dd4e8aa532a050e182c5cc
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-ciliated_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF608 CYP4B1 SIX1 SIX2	8.65e-05	196	53	4	d9426eba69047166ffa8179f1654e011c1020328
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HSPG2 CYP4B1 PRICKLE2 PKDCC	8.83e-05	197	53	4	17344464fdcc5ba0c03959696b97c195f11e644c
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal-mesenchymal_stem_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HSPG2 CYP4B1 PRICKLE2 PKDCC	8.83e-05	197	53	4	3bb92dd8a94e2be3b7fe51c9a21b241215477ac7
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HSPG2 CYP4B1 PRICKLE2 PKDCC	8.83e-05	197	53	4	5b8d0d7116b20d8e27541e88ec80c9f1f477e384
ToppCell	distal-Epithelial-Mucous-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CYP4B1 FAM181A ILDR1 SIX1	9.18e-05	199	53	4	35fb7bd35e53d8ca189fe8c7744211a5201081f6
ToppCell	distal-3-Epithelial-Mucous\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CYP4B1 FAM181A ILDR1 SIX1	9.18e-05	199	53	4	64dc8a9b25cd52935bd3f956b5c65d2fd1bf4bf5
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-OPC_related-Oligodendrocyte/OPC\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	MOGS CHST14 PKDCC NUP188	9.36e-05	200	53	4	4db894cfb80fd1f9e01133f345eefd78edd4bc43
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-OPC_related\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	MOGS CHST14 PKDCC NUP188	9.36e-05	200	53	4	d46a19274c2836ce7494790ce513764dedcadc79
ToppCell	distal-2-Epithelial-Basal\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CYP4B1 FAM181A SIX1 PTK7	9.36e-05	200	53	4	9beb128841c50241aa819261f21bf66f881ea125
Computational	B lymphoma expression clusters.	ZNF608 NPIPB3 PTK7 SORL1	1.40e-04	112	26	4	MODULE_456
Disease	triglycerides to total lipids in medium LDL percentage	LPA NPIPA1 NPIPA2	5.77e-05	50	44	3	EFO_0022334
Disease	triglycerides to total lipids in large LDL percentage	LPA NPIPA1 NPIPA2	6.13e-05	51	44	3	EFO_0022331
Disease	triglycerides to total lipids in small VLDL percentage	LPA NPIPA1 NPIPA2	9.01e-05	58	44	3	EFO_0022338
Disease	phosphatidylcholine 40:7 measurement	NPIPA1 NPIPA2	1.68e-04	13	44	2	EFO_0021477
Disease	total cholesterol measurement, very low density lipoprotein cholesterol measurement	LPA SP6 NPIPA1 NPIPA2	3.46e-04	224	44	4	EFO_0004574, EFO_0008317
Disease	cholesteryl ester measurement, very low density lipoprotein cholesterol measurement	LPA SP6 NPIPA1 NPIPA2	3.52e-04	225	44	4	EFO_0008317, EFO_0010351
Disease	total cholesterol measurement, intermediate density lipoprotein measurement	LPA NPIPA1 NPIPA2	4.39e-04	99	44	3	EFO_0004574, EFO_0008595
Disease	free cholesterol measurement, intermediate density lipoprotein measurement	LPA NPIPA1 NPIPA2	5.07e-04	104	44	3	EFO_0008591, EFO_0008595
Disease	Bilateral Wilms Tumor	SIX1 SIX2	8.60e-04	29	44	2	C2930471
Disease	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	LPA SP6 NPIPA1 NPIPA2	9.22e-04	291	44	4	EFO_0008317, EFO_0020946
Disease	Nephroblastoma	SIX1 SIX2	1.33e-03	36	44	2	C0027708
Disease	lysophosphatidylcholine 20:3 measurement	NPIPA1 NPIPA2	1.64e-03	40	44	2	EFO_0010362
Disease	Craniofacial Abnormalities	HSPG2 CHST14 SIX1	1.64e-03	156	44	3	C0376634
Disease	age-related macular degeneration, disease progression measurement	CYP4B1 TRAPPC9	1.72e-03	41	44	2	EFO_0001365, EFO_0008336
Disease	retinal nerve fibre layer thickness measurement	NPIPA1 NPIPA2	1.89e-03	43	44	2	EFO_0600004
Disease	cholesteryl ester 20:3 measurement	NPIPA1 NPIPA2	2.44e-03	49	44	2	EFO_0010347

Protein segments in the cluster

Peptide	Gene	Start	Entry
QIWFSHSHEAPGYPR	BAHCC1	111	Q9P281
YTYSRITMEPNPHWH	ALKBH3	141	Q96Q83
SPWHADDRHYNSRAP	DENND6B	106	Q8NEG7
EHRHSSGLPYWPYLT	NPIPB3	221	Q92617
HYFYWSREDGRPVPS	HSPG2	1706	P98160
ASRHRWPTENYGPDS	RGPD5	836	Q99666
ASRHRWPTENYGPDS	RGPD8	836	O14715
LYTFRYHEWPRGHAP	LARGE2	581	Q8N3Y3
YHEWPRGHAPTDYAR	LARGE2	586	Q8N3Y3
EHRHSSGLPYWPYLT	NPIPA1	221	Q9UND3
EHRHSSGLPYWPYLT	NPIPB12	221	F8W0I5
HSYPDTAQGLWHRSY	OR51J1	136	Q9H342
PWDLREGRSHHHYPD	ILDR1	361	Q86SU0
PIDDHFTYSRYPWHR	LY75	881	O60449
EHRHSSGLPYWPYLT	NPIPB5	221	A8MRT5
QESEGHPRPHYSWYR	JAM3	161	Q9BX67
EHRHSSGLPYWPYLT	NPIPA3	221	F8WFD2
HGKRYSPGESWHPYL	CHRDL2	36	Q6WN34
HRHSSGLPYWPYLTA	NPIPA2	241	E9PIF3
EHRHSSGLPYWPYLT	NPIPB4	221	C9JG80
SFYGQRNSEHDPPYW	MOGS	736	Q13724
EHRHSSGLPYWPYLT	NPIPB11	221	E5RHQ5
DPIWRSREEPYHYGN	PRICKLE2	391	Q7Z3G6
PPGEDYSHRRYSWNV	DUSP11	331	O75319
GAHWGRYRPPTFHVQ	CRISPLD1	121	Q9H336
TPHWHQRTTEYYPNG	LPA	1196	P08519
MTPHWHQRTTEYYPN	LPA	1301	P08519
YHNDFIYWLTPHGRR	CYP4B1	231	P13584
EHRHSSGLPYWPYLT	NPIPB13	221	A6NJU9
ASRHRWPTENYGPDS	RGPD1	821	P0DJD0
FWEEPRPTHSYHVGL	FAM181A	201	Q8N9Y4
EHRHSSGLPYWPYLT	NPIPA7	221	E9PJI5
EHRHSSGLPYWPYLT	NPIPA8	221	P0DM63
VYSPPEWIRYHRYHG	PIM1	206	P11309
REALPGPHYYTWGDH	SORL1	531	Q92673
TIPQEDYRCWPSYHH	PKDCC	416	Q504Y2
EHRHSSGLPYWPYLT	NPIPA5	221	E9PKD4
RVYSPPEWISRHQYH	PIM2	201	Q9P1W9
RGVLREWYAHNPYPS	SIX1	136	Q15475
SHHYESWFRPTHPGA	SP6	101	Q3SY56
GYRHWHADLRPDDSP	SARDH	776	Q9UL12
VTRPHSGPAVYFWRH	SREBF1	571	P36956
AWYRPASPESLHYHL	CHST14	326	Q8NCH0
RTQYVHSPYDRPGWN	SYNGAP1	31	Q96PV0
GTWHEFPSPHQPRYD	KBTBD13	236	C9JR72
PSYHKWRYNSHGVRE	NUP188	716	Q5SRE5
SPPEWIRYHRYHGRS	PIM3	211	Q86V86
EHRHSSGLPYWPYLT	NPIPB2	236	A6NJ64
RSVLREWYAHNPYPS	SIX2	136	Q9NPC8
HYQYLSWPDHGVPSE	PTPN6	411	P29350
DPDSRTWHHYVYQPK	ZNF608	1236	Q9ULD9
RYRHHYPPENNEWGD	TRAPPC9	56	Q96Q05
HIDGHPRPTYQWFRD	PTK7	151	Q13308
PRERSARGHWYPYNE	ZBTB34	356	Q8NCN2
PYPRYTDDWFNSHGT	PCSK2	196	P16519