Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	peptide transmembrane transporter activity	SLC15A2 DISP1	1.07e-04	9	35	2	GO:1904680
GeneOntologyMolecularFunction	chromatin binding	ATRN MED1 KAT6B KLF4 NFAT5 ASH1L PRDM1	2.51e-04	739	35	7	GO:0003682
GeneOntologyMolecularFunction	promoter-specific chromatin binding	MED1 KLF4 PRDM1	4.12e-04	83	35	3	GO:1990841
GeneOntologyMolecularFunction	transcription coregulator binding	HIF1A MED1 KLF4	1.87e-03	140	35	3	GO:0001221
GeneOntologyBiologicalProcess	embryonic organ development	TPO HOXB3 HIF1A C2CD3 ACVR1 MED1 PLS1 PRDM1	3.51e-06	561	35	8	GO:0048568
GeneOntologyBiologicalProcess	embryo development	TPO HOXB3 HIF1A C2CD3 ACVR1 MED1 KLF4 PLS1 AMOT DISP1 PRDM1	1.58e-05	1437	35	11	GO:0009790
GeneOntologyBiologicalProcess	embryonic morphogenesis	HOXB3 HIF1A C2CD3 ACVR1 MED1 KLF4 PLS1 AMOT	2.02e-05	713	35	8	GO:0048598
GeneOntologyBiologicalProcess	embryonic hemopoiesis	TPO HIF1A MED1	2.15e-05	32	35	3	GO:0035162
GeneOntologyBiologicalProcess	embryonic heart tube development	HIF1A C2CD3 ACVR1 MED1	2.73e-05	103	35	4	GO:0035050
GeneOntologyBiologicalProcess	in utero embryonic development	HIF1A C2CD3 ACVR1 MED1 KLF4 AMOT PRDM1	5.40e-05	596	35	7	GO:0001701
GeneOntologyBiologicalProcess	chordate embryonic development	HOXB3 HIF1A C2CD3 ACVR1 MED1 KLF4 AMOT PRDM1	1.10e-04	906	35	8	GO:0043009
GeneOntologyBiologicalProcess	hormone metabolic process	TPO PLB1 HIF1A MED1 DISP1	1.14e-04	286	35	5	GO:0042445
GeneOntologyBiologicalProcess	formation of translation preinitiation complex	MCTS2 MCTS1	1.25e-04	10	35	2	GO:0001731
GeneOntologyBiologicalProcess	embryo development ending in birth or egg hatching	HOXB3 HIF1A C2CD3 ACVR1 MED1 KLF4 AMOT PRDM1	1.31e-04	929	35	8	GO:0009792
GeneOntologyBiologicalProcess	determination of left/right symmetry	HIF1A C2CD3 ACVR1 DISP1	1.31e-04	154	35	4	GO:0007368
GeneOntologyBiologicalProcess	cardiac ventricle development	HIF1A ACVR1 MED1 PRDM1	1.55e-04	161	35	4	GO:0003231
GeneOntologyBiologicalProcess	left/right pattern formation	HIF1A C2CD3 ACVR1 DISP1	1.59e-04	162	35	4	GO:0060972
GeneOntologyBiologicalProcess	determination of bilateral symmetry	HIF1A C2CD3 ACVR1 DISP1	1.70e-04	165	35	4	GO:0009855
GeneOntologyBiologicalProcess	specification of symmetry	HIF1A C2CD3 ACVR1 DISP1	1.70e-04	165	35	4	GO:0009799
GeneOntologyBiologicalProcess	maternal process involved in female pregnancy	MED1 ASH1L PRDM1	2.57e-04	73	35	3	GO:0060135
GeneOntologyBiologicalProcess	embryonic organ morphogenesis	HOXB3 HIF1A C2CD3 ACVR1 PLS1	2.96e-04	351	35	5	GO:0048562
GeneOntologyBiologicalProcess	hemoglobin biosynthetic process	HIF1A KLF4	3.31e-04	16	35	2	GO:0042541
GeneOntologyBiologicalProcess	placenta development	HIF1A MED1 ASH1L PRDM1	3.35e-04	197	35	4	GO:0001890
GeneOntologyBiologicalProcess	embryonic heart tube morphogenesis	HIF1A C2CD3 ACVR1	3.36e-04	80	35	3	GO:0003143
GeneOntologyBiologicalProcess	hormone biosynthetic process	TPO HIF1A MED1	3.75e-04	83	35	3	GO:0042446
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	HOXB3 HIF1A ACVR1 MED1 KAT6B KLF4 NFAT5 CDK7 ASH1L	3.98e-04	1390	35	9	GO:0045944
GeneOntologyBiologicalProcess	cardiac chamber development	HIF1A ACVR1 MED1 PRDM1	4.42e-04	212	35	4	GO:0003205
GeneOntologyBiologicalProcess	intestinal epithelial cell development	HIF1A PRDM1	7.54e-04	24	35	2	GO:0060576
GeneOntologyBiologicalProcess	hemoglobin metabolic process	HIF1A KLF4	7.54e-04	24	35	2	GO:0020027
Domain	SET	ASH1L PRDM1	2.52e-03	41	34	2	PF00856
Domain	SET	ASH1L PRDM1	3.17e-03	46	34	2	SM00317
Domain	SET_dom	ASH1L PRDM1	3.73e-03	50	34	2	IPR001214
Domain	SET	ASH1L PRDM1	3.73e-03	50	34	2	PS50280
Domain	PHD	KAT6B ASH1L	8.21e-03	75	34	2	PF00628
Domain	Znf_PHD-finger	KAT6B ASH1L	9.08e-03	79	34	2	IPR019787
Domain	C_TYPE_LECTIN_1	ATRN MRC1	9.30e-03	80	34	2	PS00615
Domain	Lectin_C	ATRN MRC1	1.02e-02	84	34	2	PF00059
Domain	CLECT	ATRN MRC1	1.02e-02	84	34	2	SM00034
Domain	C_TYPE_LECTIN_2	ATRN MRC1	1.04e-02	85	34	2	PS50041
Domain	C-type_lectin-like	ATRN MRC1	1.07e-02	86	34	2	IPR001304
Domain	PHD	KAT6B ASH1L	1.14e-02	89	34	2	SM00249
Domain	Znf_PHD	KAT6B ASH1L	1.19e-02	91	34	2	IPR001965
Domain	ZF_PHD_2	KAT6B ASH1L	1.29e-02	95	34	2	PS50016
Domain	ZF_PHD_1	KAT6B ASH1L	1.32e-02	96	34	2	PS01359
Domain	-	ATRN MRC1	1.34e-02	97	34	2	3.10.100.10
Domain	C-type_lectin-like/link	ATRN MRC1	1.40e-02	99	34	2	IPR016186
Domain	Ig_E-set	NXPE2 NFAT5	1.53e-02	104	34	2	IPR014756
Pubmed	Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells.	KLF4 PRDM1	9.84e-07	2	35	2	26431332
Pubmed	HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.	HIF1A NFAT5	9.84e-07	2	35	2	30982460
Pubmed	Targeting cyclin-dependent kinase 7-association between CDK7 and pMED1 expression in prostate cancer tissue.	MED1 CDK7	9.84e-07	2	35	2	35512686
Pubmed	A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication.	MRC1 HOXB3 AFF2 AMOT PRDM1	2.57e-06	218	35	5	19460752
Pubmed	SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway.	HIF1A RPS6KB1	2.95e-06	3	35	2	15474452
Pubmed	Spatiotemporal expression of retrogene-host pair Mcts2/H13 in mouse embryo, and Mcts2 has no influence on H13 transcription pattern in NIH/3T3 cells.	MCTS2 MCTS1	2.95e-06	3	35	2	24063864
Pubmed	P70S6K 1 regulation of angiogenesis through VEGF and HIF-1alpha expression.	HIF1A RPS6KB1	2.95e-06	3	35	2	20599538
Pubmed	The N-terminal region of p27 inhibits HIF-1α protein translation in ribosomal protein S6-dependent manner by regulating PHLPP-Ras-ERK-p90RSK axis.	HIF1A RPS6KB1	2.95e-06	3	35	2	25412313
Pubmed	A case-by-case evolutionary analysis of four imprinted retrogenes.	MCTS2 MCTS1	5.90e-06	4	35	2	21166792
Pubmed	Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo.	RPS6KB1 CDK7	5.90e-06	4	35	2	12023960
Pubmed	Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells.	HIF1A RPS6KB1	5.90e-06	4	35	2	14729612
Pubmed	Loss of SNAIL inhibits cellular growth and metabolism through the miR-128-mediated RPS6KB1/HIF-1α/PKM2 signaling pathway in prostate cancer cells.	HIF1A RPS6KB1	9.82e-06	5	35	2	24859886
Pubmed	Human rhomboid family-1 suppresses oxygen-independent degradation of hypoxia-inducible factor-1α in breast cancer.	HIF1A RHBDF1	9.82e-06	5	35	2	24648344
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	HIF1A ZNF334 KAT6B KLF4 NFAT5 ASH1L PRDM1	1.36e-05	808	35	7	20412781
Pubmed	Tanshinone IIA inhibits HIF-1α and VEGF expression in breast cancer cells via mTOR/p70S6K/RPS6/4E-BP1 signaling pathway.	HIF1A RPS6KB1	1.47e-05	6	35	2	25659153
Pubmed	The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy.	SLC15A2 RPS6KB1	2.06e-05	7	35	2	27553280
Pubmed	Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity.	HIF1A PRDM1	2.06e-05	7	35	2	32901017
Pubmed	A screen for retrotransposed imprinted genes reveals an association between X chromosome homology and maternal germ-line methylation.	MCTS2 MCTS1	2.74e-05	8	35	2	17291163
Pubmed	C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4.	MED1 KLF4	2.74e-05	8	35	2	26974661
Pubmed	mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3.	HIF1A RPS6KB1	2.74e-05	8	35	2	24931163
Pubmed	mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation.	HIF1A RPS6KB1	3.53e-05	9	35	2	28798047
Pubmed	HIF1 inhibitor acriflavine rescues early-onset preeclampsia phenotype in mice lacking placental prolyl hydroxylase domain protein 2.	HIF1A AMOT	7.62e-05	13	35	2	36227697
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	RHBDF1 KLF4 NFAT5 UBE2V1 AMOT RPS6KB1 ASH1L	8.78e-05	1084	35	7	11544199
Pubmed	Regulation of ubiquitin-proteasome system-mediated Tip110 protein degradation by USP15.	HIF1A AMOT	1.17e-04	16	35	2	24984263
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	AFF2 UBE2V1 DISP1 RPS6KB1 MCTS1 ASH1L	1.40e-04	807	35	6	30575818
Pubmed	The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification.	ACVR1 KLF4 PRDM1	1.41e-04	100	35	3	24859004
Pubmed	The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes.	KLF4 PRDM1	2.04e-04	21	35	2	21670299
Pubmed	ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.	UBE2V1 RPS6KB1	2.24e-04	22	35	2	22797923
Pubmed	Global gene expression analysis of murine limb development.	KAT6B NFAT5 PRDM1	2.24e-04	117	35	3	22174793
Pubmed	Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells.	HIF1A RPS6KB1	2.46e-04	23	35	2	24463367
Pubmed	A census of human transcription factors: function, expression and evolution.	HOXB3 HIF1A KLF4 NFAT5 ASH1L PRDM1	2.65e-04	908	35	6	19274049
Pubmed	An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets.	HIF1A PRDM1	3.15e-04	26	35	2	33238123
Pubmed	Unconventional myosin VI in the heart: Involvement in cardiac dysfunction progressing with age.	HIF1A RPS6KB1	3.40e-04	27	35	2	37169038
Pubmed	Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1α-glycolysis axis.	HIF1A NFAT5	4.49e-04	31	35	2	36127325
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-4\|TCGA-Thryoid / Sample_Type by Project: Shred V9	ACVR1 RHBDF1 LYST PLS1 AMOT	3.18e-07	184	35	5	d9659d1e4465fec68f48a22edef443f354f6c7cf
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Interstitial_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 RHBDF1 PPAT SLC15A2	1.15e-05	179	35	4	6eb84fe9691ad40127b2d1f1c672428333c8fab4
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-lung_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 RHBDF1 PPAT SLC15A2	1.15e-05	179	35	4	2c3abd646d2c8992e8ff76a824eab5beba8ba4c6
ToppCell	Macrophages-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	MRC1 KLF4 UBE2V1 MCTS1	1.61e-05	195	35	4	e48bf57e6da23fbb4637a02387155f825455c49f
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CFAP54 AFF2 SLC15A2 PRDM1	1.65e-05	196	35	4	fd18a9ae8401121ae276adff1a85d5f938e2df91
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_plasma\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CFAP54 AFF2 SLC15A2 PRDM1	1.71e-05	198	35	4	567fcf882c8612356946240843525b786f3c8dbe
Disease	type 2 diabetes mellitus (implicated_via_orthology)	AFF2 RPS6KB1 CDK7	2.42e-04	105	34	3	DOID:9352 (implicated_via_orthology)
Disease	Pilocytic Astrocytoma	HIF1A ACVR1	3.80e-04	25	34	2	C0334583
Disease	Cerebral Astrocytoma	HIF1A ACVR1	3.80e-04	25	34	2	C0750935
Disease	Intracranial Astrocytoma	HIF1A ACVR1	3.80e-04	25	34	2	C0750936
Disease	Astrocytoma	HIF1A ACVR1	3.80e-04	25	34	2	C0004114
Disease	Juvenile Pilocytic Astrocytoma	HIF1A ACVR1	3.80e-04	25	34	2	C0280783
Disease	Diffuse Astrocytoma	HIF1A ACVR1	3.80e-04	25	34	2	C0280785
Disease	Grade I Astrocytoma	HIF1A ACVR1	3.80e-04	25	34	2	C1704230
Disease	Subependymal Giant Cell Astrocytoma	HIF1A ACVR1	3.80e-04	25	34	2	C0205768
Disease	Mixed oligoastrocytoma	HIF1A ACVR1	3.80e-04	25	34	2	C0547065
Disease	Childhood Cerebral Astrocytoma	HIF1A ACVR1	3.80e-04	25	34	2	C0338070
Disease	Gemistocytic astrocytoma	HIF1A ACVR1	4.12e-04	26	34	2	C0334581
Disease	Protoplasmic astrocytoma	HIF1A ACVR1	4.12e-04	26	34	2	C0334580
Disease	Fibrillary Astrocytoma	HIF1A ACVR1	4.12e-04	26	34	2	C0334582
Disease	Anaplastic astrocytoma	HIF1A ACVR1	4.44e-04	27	34	2	C0334579
Disease	Congenital Heart Defects	HIF1A KLF4	1.18e-03	44	34	2	C0018798
Disease	Gastrointestinal Stromal Sarcoma	C2CD3 DISP1	1.35e-03	47	34	2	C3179349
Disease	Gastrointestinal Stromal Tumors	C2CD3 DISP1	1.52e-03	50	34	2	C0238198
Disease	Diffuse Large B-Cell Lymphoma	RPS6KB1 PRDM1	1.84e-03	55	34	2	C0079744
Disease	melanoma	ACVR1 FHIP2A SLC15A2	2.90e-03	248	34	3	C0025202
Disease	hepatocellular carcinoma (is_marker_for)	HIF1A KLF4 PRDM1	4.98e-03	301	34	3	DOID:684 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EYPFKGMPPQSVVCK	AMOT	241	Q4VCS5
KQPPVYCTSPDFKMG	ASH1L	521	Q9NR48
QIFYGKNMPCPIPAG	CFAP54	2136	Q96N23
KNMPCPIPAGYKATG	CFAP54	2141	Q96N23
YKQATMGPCLVPRPG	ACBD4	46	Q8NC06
PPGLYCKTSMGQQKP	AFF2	271	P51816
QGKMTCKTPPSPGQA	ACVR1	76	Q04771
GGAYIVCINPKMKLP	DISP1	731	Q96F81
KYKVTPQMGTPSPGK	KAT6B	636	Q8WYB5
YNGGPPRTCPKIKQE	KLF4	266	O43474
IMCPGLTSPGAKLYP	MCTS1	111	Q9ULC4
IMCPGLTSPGAKLYP	MCTS2	111	A0A3B3IRV3
NQPQCGYKKPPMTCL	HIF1A	206	Q16665
CIEGSYKGPVKMPSQ	ATRN	1016	O75882
YKGPVKMPSQAPTGN	ATRN	1021	O75882
PPYPALGGNMKKIEN	PLS1	446	Q14651
YMLPPKCPNTCLANK	TPO	136	P07202
PNSGPYKKQAFPMIS	RPS6KB1	501	P23443
TGVKKSPMLCGQYPV	NFAT5	261	O94916
SPMLCGQYPVKSEGK	NFAT5	266	O94916
QMTPGKKSYAGPPPK	C2CD3	556	Q4AC94
KMKYFSNRPGPTPGC	CDK7	291	P50613
SNYQPPLKGCGAPQK	HOXB3	306	P14651
PYCKMIGPTIPTDQK	C17orf80	26	Q9BSJ5
PNHTSVMPCKYGKPV	LYST	1691	Q99698
LYTLGKADCPPGMKQ	FHIP2A	91	Q5W0V3
AMGSKIYNKPPPEGN	SLC15A2	236	Q16348
VKKNLPPASSPGYGM	MED1	536	Q15648
PLGYICKMKSRSQGP	MRC1	481	P22897
KNCQIGMKTPFPSGY	NXPE2	316	Q96DL1
PPLYVGPCQLGMQKI	RHBDF1	141	Q96CC6
PKFLLPPYGMNCNGL	PRDM1	411	O75626
KHGRPMKCPSQESPY	PLB1	326	Q6P1J6
PPNLAPLCVSYKNMK	UHRF1BP1L	1091	A0JNW5
PAGQKECFYQPMPLK	TMED5	41	Q9Y3A6
SVPSRKMPYKCNPGG	ZNF334	126	Q9HCZ1
KMPYKCNPGGNSLKT	ZNF334	131	Q9HCZ1
GGKLKCPYCPMEQNP	RMND5B	371	Q96G75
PIKYPCFMGINIPTK	PPAT	421	Q06203
KENMKLPQPPEGQCY	UBE2V1	131	Q13404
IPPYVMKCPSNGLCS	TM2D3	61	Q9BRN9