| GeneOntologyMolecularFunction | cysteine-type deubiquitinase activity | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 DESI2 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 2.93e-35 | 114 | 40 | 20 | GO:0004843 |
| GeneOntologyMolecularFunction | deubiquitinase activity | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 DESI2 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 1.81e-34 | 124 | 40 | 20 | GO:0101005 |
| GeneOntologyMolecularFunction | ubiquitin-like protein peptidase activity | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 DESI2 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 1.55e-33 | 137 | 40 | 20 | GO:0019783 |
| GeneOntologyMolecularFunction | cysteine-type peptidase activity | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 DESI2 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 1.93e-30 | 192 | 40 | 20 | GO:0008234 |
| GeneOntologyMolecularFunction | peptidase activity | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 DESI2 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 PREPL USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 3.53e-21 | 654 | 40 | 21 | GO:0008233 |
| GeneOntologyMolecularFunction | RNA polymerase II transcription regulatory region sequence-specific DNA binding | ZNF711 ZNF823 ZNF485 ZNF836 ZNF280B ZNF573 ZNF224 ZNF560 ZNF679 MTF1 ZNF335 ZIC1 ZIC2 ZIC3 | 4.42e-07 | 1459 | 40 | 14 | GO:0000977 |
| GeneOntologyMolecularFunction | DNA-binding transcription factor activity, RNA polymerase II-specific | ZNF711 ZNF823 ZNF485 ZNF836 ZNF280B ZNF573 ZNF224 ZNF560 ZNF679 MTF1 ZIC1 ZIC2 ZIC3 | 2.07e-06 | 1412 | 40 | 13 | GO:0000981 |
| GeneOntologyMolecularFunction | RNA polymerase II cis-regulatory region sequence-specific DNA binding | ZNF711 ZNF485 ZNF836 ZNF280B ZNF573 ZNF224 ZNF679 MTF1 ZNF335 ZIC1 ZIC2 ZIC3 | 3.54e-06 | 1244 | 40 | 12 | GO:0000978 |
| GeneOntologyMolecularFunction | cis-regulatory region sequence-specific DNA binding | ZNF711 ZNF485 ZNF836 ZNF280B ZNF573 ZNF224 ZNF679 MTF1 ZNF335 ZIC1 ZIC2 ZIC3 | 4.42e-06 | 1271 | 40 | 12 | GO:0000987 |
| GeneOntologyMolecularFunction | DNA-binding transcription activator activity, RNA polymerase II-specific | ZNF485 ZNF836 ZNF224 MTF1 ZIC1 ZIC2 ZIC3 | 1.10e-04 | 560 | 40 | 7 | GO:0001228 |
| GeneOntologyMolecularFunction | DNA-binding transcription activator activity | ZNF485 ZNF836 ZNF224 MTF1 ZIC1 ZIC2 ZIC3 | 1.17e-04 | 566 | 40 | 7 | GO:0001216 |
| GeneOntologyMolecularFunction | hyaluronic acid binding | STAB2 USP17L24 | 1.54e-03 | 29 | 40 | 2 | GO:0005540 |
| GeneOntologyBiologicalProcess | protein deubiquitination | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 DESI2 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 5.68e-35 | 125 | 39 | 20 | GO:0016579 |
| GeneOntologyBiologicalProcess | protein modification by small protein removal | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 DESI2 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 1.18e-33 | 144 | 39 | 20 | GO:0070646 |
| GeneOntologyBiologicalProcess | protein modification by small protein conjugation or removal | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 DESI2 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 1.46e-16 | 1009 | 39 | 20 | GO:0070647 |
| GeneOntologyBiologicalProcess | post-translational protein modification | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 DESI2 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 4.84e-16 | 1074 | 39 | 20 | GO:0043687 |
| GeneOntologyBiologicalProcess | central nervous system segmentation | ZIC2 ZIC3 | 3.47e-05 | 5 | 39 | 2 | GO:0035283 |
| GeneOntologyBiologicalProcess | axial mesoderm development | ZIC2 ZIC3 | 1.90e-04 | 11 | 39 | 2 | GO:0048318 |
| GeneOntologyBiologicalProcess | neural plate development | ZIC2 ZIC3 | 3.12e-04 | 14 | 39 | 2 | GO:0001840 |
| GeneOntologyBiologicalProcess | positive regulation of transcription by RNA polymerase II | ZNF711 ZNF485 ZNF836 ZNF224 MTF1 ZNF335 ZIC1 ZIC2 ZIC3 | 9.35e-04 | 1390 | 39 | 9 | GO:0045944 |
| GeneOntologyBiologicalProcess | paraxial mesoderm development | ZIC2 ZIC3 | 9.37e-04 | 24 | 39 | 2 | GO:0048339 |
| GeneOntologyCellularComponent | endoplasmic reticulum membrane | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 4.81e-12 | 1293 | 40 | 18 | GO:0005789 |
| GeneOntologyCellularComponent | endoplasmic reticulum subcompartment | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 5.20e-12 | 1299 | 40 | 18 | GO:0098827 |
| GeneOntologyCellularComponent | nuclear outer membrane-endoplasmic reticulum membrane network | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 7.43e-12 | 1327 | 40 | 18 | GO:0042175 |
| MousePheno | increased trophectoderm apoptosis | USP17L2 USP17L15 USP17L13 | 8.33e-08 | 8 | 17 | 3 | MP:0012119 |
| MousePheno | decreased regulatory T cell number | USP17L2 USP17L15 ZNF335 USP17L13 | 9.09e-07 | 64 | 17 | 4 | MP:0004974 |
| MousePheno | increased thymus weight | USP17L2 USP17L15 USP17L13 | 2.98e-06 | 24 | 17 | 3 | MP:0004955 |
| MousePheno | abnormal regulatory T cell number | USP17L2 USP17L15 ZNF335 USP17L13 | 9.52e-06 | 115 | 17 | 4 | MP:0004972 |
| MousePheno | abnormal regulatory T cell morphology | USP17L2 USP17L15 ZNF335 USP17L13 | 1.02e-05 | 117 | 17 | 4 | MP:0004941 |
| MousePheno | abnormal embryonic tissue physiology | USP17L2 USP17L15 ZIC2 ZIC3 USP17L13 | 2.10e-05 | 297 | 17 | 5 | MP:0008932 |
| MousePheno | increased embryonic tissue cell apoptosis | USP17L2 USP17L15 ZIC2 USP17L13 | 2.94e-05 | 153 | 17 | 4 | MP:0013504 |
| MousePheno | abnormal thymus weight | USP17L2 USP17L15 USP17L13 | 4.90e-05 | 60 | 17 | 3 | MP:0004954 |
| MousePheno | abnormal embryonic tissue cell apoptosis | USP17L2 USP17L15 ZIC2 USP17L13 | 5.55e-05 | 180 | 17 | 4 | MP:0013503 |
| MousePheno | cerebellum vermis hypoplasia | ZIC1 ZIC3 | 6.23e-05 | 10 | 17 | 2 | MP:0000866 |
| MousePheno | embryonic lethality before implantation, complete penetrance | USP17L2 USP17L15 ZNF335 USP17L13 | 8.86e-05 | 203 | 17 | 4 | MP:0011094 |
| MousePheno | embryonic lethality before implantation | USP17L2 USP17L15 ZNF335 USP17L13 | 1.75e-04 | 242 | 17 | 4 | MP:0006204 |
| MousePheno | failure of blastocyst to hatch from the zona pellucida | USP17L2 USP17L15 USP17L13 | 2.74e-04 | 107 | 17 | 3 | MP:0003694 |
| MousePheno | abnormal blastocyst hatching | USP17L2 USP17L15 USP17L13 | 3.22e-04 | 113 | 17 | 3 | MP:0003693 |
| MousePheno | anencephaly | ZIC2 ZIC3 | 3.78e-04 | 24 | 17 | 2 | MP:0001890 |
| MousePheno | right pulmonary isomerism | ZIC2 ZIC3 | 4.11e-04 | 25 | 17 | 2 | MP:0000531 |
| MousePheno | abnormal neural plate morphology | ZIC2 ZIC3 | 4.45e-04 | 26 | 17 | 2 | MP:0005657 |
| MousePheno | hypotonia | PREPL ZIC1 | 4.80e-04 | 27 | 17 | 2 | MP:0004144 |
| MousePheno | abnormal left lung morphology | ZIC2 ZIC3 | 5.16e-04 | 28 | 17 | 2 | MP:0009569 |
| MousePheno | right-sided isomerism | ZIC2 ZIC3 | 5.94e-04 | 30 | 17 | 2 | MP:0000508 |
| MousePheno | right-sided stomach | ZIC2 ZIC3 | 6.34e-04 | 31 | 17 | 2 | MP:0010808 |
| MousePheno | delayed neural tube closure | ZIC2 ZIC3 | 6.34e-04 | 31 | 17 | 2 | MP:0002621 |
| MousePheno | abnormal CD8-positive, alpha-beta T cell number | USP17L2 USP17L15 ZNF335 USP17L13 | 7.25e-04 | 352 | 17 | 4 | MP:0008077 |
| MousePheno | abnormal stomach position or orientation | ZIC2 ZIC3 | 8.56e-04 | 36 | 17 | 2 | MP:0010807 |
| MousePheno | abnormal cerebellum vermis morphology | ZIC1 ZIC3 | 9.04e-04 | 37 | 17 | 2 | MP:0000864 |
| MousePheno | abnormal CD8-positive, alpha beta T cell morphology | USP17L2 USP17L15 ZNF335 USP17L13 | 9.56e-04 | 379 | 17 | 4 | MP:0005010 |
| MousePheno | abnormal CD4-positive, alpha-beta T cell number | USP17L2 USP17L15 ZNF335 USP17L13 | 1.07e-03 | 391 | 17 | 4 | MP:0008073 |
| MousePheno | abnormal preimplantation embryo development | USP17L2 USP17L15 USP17L13 | 1.08e-03 | 171 | 17 | 3 | MP:0009781 |
| MousePheno | increased CD8-positive, alpha-beta T cell number | USP17L2 USP17L15 USP17L13 | 1.57e-03 | 195 | 17 | 3 | MP:0008078 |
| MousePheno | abnormal CD4-positive, alpha beta T cell morphology | USP17L2 USP17L15 ZNF335 USP17L13 | 1.62e-03 | 437 | 17 | 4 | MP:0002432 |
| MousePheno | dextrocardia | ZIC2 ZIC3 | 1.71e-03 | 51 | 17 | 2 | MP:0000644 |
| MousePheno | abnormal digestive organ placement | ZIC2 ZIC3 | 2.14e-03 | 57 | 17 | 2 | MP:0003283 |
| MousePheno | abnormal lung position or orientation | ZIC2 ZIC3 | 2.14e-03 | 57 | 17 | 2 | MP:0010853 |
| MousePheno | right aortic arch | ZIC2 ZIC3 | 2.36e-03 | 60 | 17 | 2 | MP:0004158 |
| MousePheno | abnormal notochord morphology | ZIC2 ZIC3 | 2.60e-03 | 63 | 17 | 2 | MP:0002825 |
| MousePheno | increased CD4-positive, alpha-beta T cell number | USP17L2 USP17L15 USP17L13 | 2.88e-03 | 241 | 17 | 3 | MP:0008074 |
| MousePheno | abnormal muscle tone | PREPL ZIC1 | 3.02e-03 | 68 | 17 | 2 | MP:0004142 |
| MousePheno | abnormal inferior vena cava morphology | ZIC2 ZIC3 | 3.02e-03 | 68 | 17 | 2 | MP:0006063 |
| MousePheno | abnormal cerebellum lobule morphology | ZIC1 ZIC3 | 3.11e-03 | 69 | 17 | 2 | MP:0009964 |
| MousePheno | abnormal B cell number | USP17L2 USP17L15 ZNF335 USP17L13 | 3.19e-03 | 526 | 17 | 4 | MP:0002458 |
| MousePheno | abnormal alpha-beta T cell number | USP17L2 USP17L15 ZNF335 USP17L13 | 3.55e-03 | 542 | 17 | 4 | MP:0012763 |
| MousePheno | abnormal heart position or orientation | ZIC2 ZIC3 | 3.57e-03 | 74 | 17 | 2 | MP:0006065 |
| MousePheno | abnormal vena cava morphology | ZIC2 ZIC3 | 3.86e-03 | 77 | 17 | 2 | MP:0006062 |
| MousePheno | increased B cell number | USP17L2 USP17L15 USP17L13 | 4.01e-03 | 271 | 17 | 3 | MP:0005014 |
| MousePheno | decreased T cell number | USP17L2 USP17L15 ZNF335 USP17L13 | 4.15e-03 | 566 | 17 | 4 | MP:0005018 |
| MousePheno | abnormal embryo development | USP17L2 MTF1 USP17L15 ZIC2 ZIC3 USP17L13 | 4.19e-03 | 1370 | 17 | 6 | MP:0001672 |
| MousePheno | enlarged thymus | USP17L2 USP17L15 USP17L13 | 4.94e-03 | 292 | 17 | 3 | MP:0000709 |
| MousePheno | atrial septal defect | ZIC2 ZIC3 | 5.01e-03 | 88 | 17 | 2 | MP:0010403 |
| MousePheno | abnormal B cell morphology | USP17L2 USP17L15 ZNF335 USP17L13 | 5.02e-03 | 597 | 17 | 4 | MP:0004939 |
| MousePheno | heterotaxia | ZIC2 ZIC3 | 5.24e-03 | 90 | 17 | 2 | MP:0004133 |
| Domain | HABP4_PAIRBP1-bd | USP17L7 USP17L3 USP17L5 USP17L21 USP17L19 USP17L2 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18 | 2.52e-37 | 16 | 39 | 14 | IPR006861 |
| Domain | HABP4_PAI-RBP1 | USP17L7 USP17L3 USP17L5 USP17L21 USP17L19 USP17L2 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18 | 2.52e-37 | 16 | 39 | 14 | PF04774 |
| Domain | UCH | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L8 USP17L24 USP17L13 USP17L18 | 1.55e-34 | 71 | 39 | 18 | PF00443 |
| Domain | USP_2 | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L8 USP17L24 USP17L13 USP17L18 | 1.55e-34 | 71 | 39 | 18 | PS00973 |
| Domain | USP_dom | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L8 USP17L24 USP17L13 USP17L18 | 2.06e-34 | 72 | 39 | 18 | IPR028889 |
| Domain | Peptidase_C19_UCH | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L8 USP17L24 USP17L13 USP17L18 | 2.06e-34 | 72 | 39 | 18 | IPR001394 |
| Domain | USP_3 | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L8 USP17L24 USP17L13 USP17L18 | 2.06e-34 | 72 | 39 | 18 | PS50235 |
| Domain | USP_CS | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L8 USP17L24 USP17L13 USP17L18 | 1.06e-32 | 66 | 39 | 17 | IPR018200 |
| Domain | USP_1 | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L8 USP17L24 USP17L13 USP17L18 | 3.32e-32 | 70 | 39 | 17 | PS00972 |
| Domain | Znf_C2H2-like | ZNF711 ZNF823 ZNF485 ZNF836 ZNF280B ZMAT4 ZNF573 ZNF224 ZNF560 ZNF679 MTF1 ZNF335 ZIC1 ZNF222 ZIC2 ZIC3 | 1.54e-12 | 796 | 39 | 16 | IPR015880 |
| Domain | Znf_C2H2 | ZNF711 ZNF823 ZNF485 ZNF836 ZNF280B ZMAT4 ZNF573 ZNF224 ZNF560 ZNF679 MTF1 ZNF335 ZIC1 ZNF222 ZIC2 ZIC3 | 1.82e-12 | 805 | 39 | 16 | IPR007087 |
| Domain | ZnF_C2H2 | ZNF711 ZNF823 ZNF485 ZNF836 ZNF280B ZMAT4 ZNF573 ZNF224 ZNF560 ZNF679 MTF1 ZNF335 ZIC1 ZNF222 ZIC2 ZIC3 | 1.93e-12 | 808 | 39 | 16 | SM00355 |
| Domain | ZINC_FINGER_C2H2_2 | ZNF711 ZNF823 ZNF485 ZNF836 ZNF280B ZNF573 ZNF224 ZNF560 ZNF679 MTF1 ZNF335 ZIC1 ZNF222 ZIC2 ZIC3 | 1.62e-11 | 775 | 39 | 15 | PS50157 |
| Domain | ZINC_FINGER_C2H2_1 | ZNF711 ZNF823 ZNF485 ZNF836 ZNF280B ZNF573 ZNF224 ZNF560 ZNF679 MTF1 ZNF335 ZIC1 ZNF222 ZIC2 ZIC3 | 1.68e-11 | 777 | 39 | 15 | PS00028 |
| Domain | - | ZNF711 ZNF823 ZNF485 ZNF836 ZNF573 ZNF224 ZNF560 ZNF679 MTF1 ZNF335 ZIC1 ZNF222 ZIC2 ZIC3 | 4.01e-11 | 679 | 39 | 14 | 3.30.160.60 |
| Domain | zf-C2H2 | ZNF711 ZNF823 ZNF485 ZNF836 ZNF573 ZNF224 ZNF560 ZNF679 MTF1 ZNF335 ZIC1 ZNF222 ZIC2 ZIC3 | 5.26e-11 | 693 | 39 | 14 | PF00096 |
| Domain | Znf_C2H2/integrase_DNA-bd | ZNF711 ZNF823 ZNF485 ZNF836 ZNF573 ZNF224 ZNF560 ZNF679 MTF1 ZNF335 ZIC1 ZNF222 ZIC2 ZIC3 | 5.36e-11 | 694 | 39 | 14 | IPR013087 |
| Domain | KRAB | ZNF823 ZNF485 ZNF836 ZNF573 ZNF224 ZNF560 ZNF679 ZNF222 | 6.17e-07 | 358 | 39 | 8 | PS50805 |
| Domain | KRAB | ZNF823 ZNF485 ZNF836 ZNF573 ZNF224 ZNF560 ZNF679 ZNF222 | 6.17e-07 | 358 | 39 | 8 | PF01352 |
| Domain | KRAB | ZNF823 ZNF485 ZNF836 ZNF573 ZNF224 ZNF560 ZNF679 ZNF222 | 7.75e-07 | 369 | 39 | 8 | SM00349 |
| Domain | KRAB | ZNF823 ZNF485 ZNF836 ZNF573 ZNF224 ZNF560 ZNF679 ZNF222 | 7.91e-07 | 370 | 39 | 8 | IPR001909 |
| Domain | zf-C2H2_6 | ZNF823 ZNF836 ZNF573 ZNF224 ZNF560 | 4.69e-04 | 314 | 39 | 5 | PF13912 |
| Pathway | REACTOME_RAS_PROCESSING | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 3.92e-37 | 45 | 37 | 18 | MM15671 |
| Pathway | REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 1.48e-24 | 191 | 37 | 18 | MM15289 |
| Pathway | REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES | USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 2.21e-23 | 221 | 37 | 18 | M27578 |
| Pathway | REACTOME_DEUBIQUITINATION | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 5.02e-22 | 262 | 37 | 18 | MM15286 |
| Pathway | REACTOME_DEUBIQUITINATION | USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 5.57e-21 | 299 | 37 | 18 | M27574 |
| Pathway | REACTOME_MAPK_FAMILY_SIGNALING_CASCADES | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 1.70e-20 | 318 | 37 | 18 | MM15278 |
| Pathway | REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 1.96e-09 | 1389 | 37 | 18 | MM15307 |
| Pathway | REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION | USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 5.14e-09 | 1475 | 37 | 18 | M19806 |
| Pubmed | Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 1.75e-52 | 21 | 40 | 18 | 12447969 |
| Pubmed | DUB-1, a deubiquitinating enzyme with growth-suppressing activity. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 1.75e-52 | 21 | 40 | 18 | 8622927 |
| Pubmed | DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 1.75e-52 | 21 | 40 | 18 | 11468161 |
| Pubmed | DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 1.75e-52 | 21 | 40 | 18 | 14583620 |
| Pubmed | DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 1.75e-52 | 21 | 40 | 18 | 18980247 |
| Pubmed | The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 1.75e-52 | 21 | 40 | 18 | 8756639 |
| Pubmed | JAK2 is required for induction of the murine DUB-1 gene. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 9.60e-52 | 22 | 40 | 18 | 9154835 |
| Pubmed | DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 1.76e-50 | 24 | 40 | 18 | 8995226 |
| Pubmed | Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 6.30e-50 | 25 | 40 | 18 | 21115691 |
| Pubmed | Cdc25A and Dub3 in a high-stakes balancing act. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 6.76e-50 | 33 | 40 | 19 | 20228807 |
| Pubmed | The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 1.53e-49 | 34 | 40 | 19 | 15780755 |
| Pubmed | The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 1.53e-49 | 34 | 40 | 19 | 20388806 |
| Pubmed | DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 1.53e-49 | 34 | 40 | 19 | 14699124 |
| Pubmed | USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 1.53e-49 | 34 | 40 | 19 | 19188362 |
| Pubmed | The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 1.53e-49 | 34 | 40 | 19 | 20403174 |
| Pubmed | The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 1.53e-49 | 34 | 40 | 19 | 10936051 |
| Pubmed | Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 1.53e-49 | 34 | 40 | 19 | 20715989 |
| Pubmed | Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 1.53e-49 | 34 | 40 | 19 | 17109758 |
| Pubmed | Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 1.53e-49 | 34 | 40 | 19 | 11941478 |
| Pubmed | Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 1.53e-49 | 34 | 40 | 19 | 9806828 |
| Pubmed | The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 1.53e-49 | 34 | 40 | 19 | 21448158 |
| Pubmed | The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 1.53e-49 | 34 | 40 | 19 | 20368735 |
| Pubmed | Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 2.05e-49 | 26 | 40 | 18 | 35816173 |
| Pubmed | Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 3.35e-49 | 35 | 40 | 19 | 21239494 |
| Pubmed | Cytokine-regulated protein degradation by the ubiquitination system. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 3.35e-49 | 35 | 40 | 19 | 16611142 |
| Pubmed | The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 7.09e-49 | 36 | 40 | 19 | 20147298 |
| Pubmed | Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 1.46e-48 | 37 | 40 | 19 | 20228808 |
| Pubmed | Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 4.52e-48 | 29 | 40 | 18 | 32527007 |
| Pubmed | DUX is a non-essential synchronizer of zygotic genome activation. | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 2.33e-42 | 50 | 40 | 18 | 31806660 |
| Pubmed | USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. | USP17L7 ZNF711 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 2.01e-22 | 674 | 40 | 19 | 37196079 |
| Pubmed | High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency. | USP17L7 USP17L3 USP17L4 USP17L2 USP17L1 USP17L15 USP17L8 | 1.83e-19 | 10 | 40 | 7 | 24207026 |
| Pubmed | Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells. | USP17L7 USP17L3 USP17L4 USP17L2 USP17L1 USP17L15 USP17L8 | 1.20e-18 | 12 | 40 | 7 | 24695638 |
| Pubmed | ES cell neural differentiation reveals a substantial number of novel ESTs. | USP17L7 USP17L3 USP17L4 USP17L2 USP17L1 USP17L15 USP17L8 | 5.21e-18 | 14 | 40 | 7 | 11793228 |
| Pubmed | CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1. | USP17L7 USP17L3 USP17L4 USP17L2 USP17L1 USP17L15 USP17L8 | 7.62e-17 | 19 | 40 | 7 | 28067227 |
| Pubmed | Human and mouse proteases: a comparative genomic approach. | USP17L7 USP17L3 USP17L4 USP17L2 USP17L1 USP17L15 USP17L8 | 4.99e-12 | 81 | 40 | 7 | 12838346 |
| Pubmed | A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220. | USP17L21 USP17L19 USP17L12 USP17L17 USP17L20 USP17L11 USP17L18 | 7.80e-11 | 119 | 40 | 7 | 28625976 |
| Pubmed | Genetic variants in ZIC1, ZIC2, and ZIC3 are not major risk factors for neural tube defects in humans. | ZIC1 ZIC2 ZIC3 | 1.41e-09 | 3 | 40 | 3 | 14679585 |
| Pubmed | The role of Zic family zinc finger transcription factors in the proliferation and differentiation of retinal progenitor cells. | ZIC1 ZIC2 ZIC3 | 1.41e-09 | 3 | 40 | 3 | 22024047 |
| Pubmed | Overlapping and distinct expression domains of Zic2 and Zic3 during mouse gastrulation. | ZIC1 ZIC2 ZIC3 | 1.41e-09 | 3 | 40 | 3 | 15261827 |
| Pubmed | The mouse zic gene family. Homologues of the Drosophila pair-rule gene odd-paired. | ZIC1 ZIC2 ZIC3 | 1.41e-09 | 3 | 40 | 3 | 8557628 |
| Pubmed | DNA sequence and analysis of human chromosome 8. | USP17L7 USP17L3 USP17L4 USP17L1 USP17L8 | 2.56e-09 | 48 | 40 | 5 | 16421571 |
| Pubmed | Zic4, a zinc-finger transcription factor, is expressed in the developing mouse nervous system. | ZIC1 ZIC2 ZIC3 | 5.63e-09 | 4 | 40 | 3 | 15895369 |
| Pubmed | An Evolutionarily Conserved Mesodermal Enhancer in Vertebrate Zic3. | ZIC1 ZIC2 ZIC3 | 5.63e-09 | 4 | 40 | 3 | 30297839 |
| Pubmed | Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. | ZIC1 ZIC2 ZIC3 | 5.63e-09 | 4 | 40 | 3 | 11053430 |
| Pubmed | A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. | ZIC1 ZIC2 ZIC3 | 5.63e-09 | 4 | 40 | 3 | 7931345 |
| Pubmed | Embryonic demise caused by targeted disruption of a cysteine protease Dub-2. | USP17L2 USP17L15 USP17L13 | 5.63e-09 | 4 | 40 | 3 | 22984479 |
| Pubmed | Myogenic repressor I-mfa interferes with the function of Zic family proteins. | ZIC1 ZIC2 ZIC3 | 1.41e-08 | 5 | 40 | 3 | 15207726 |
| Pubmed | Physical and functional interactions between Zic and Gli proteins. | ZIC1 ZIC2 ZIC3 | 2.81e-08 | 6 | 40 | 3 | 11238441 |
| Pubmed | Zic2 patterns binocular vision by specifying the uncrossed retinal projection. | ZIC1 ZIC2 ZIC3 | 4.92e-08 | 7 | 40 | 3 | 13678579 |
| Pubmed | The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation. | ZIC1 ZIC2 ZIC3 | 7.86e-08 | 8 | 40 | 3 | 9070329 |
| Pubmed | Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives. | ZIC1 ZIC2 ZIC3 | 1.68e-07 | 10 | 40 | 3 | 15136147 |
| Pubmed | A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis. | ZIC1 ZIC2 ZIC3 | 1.68e-07 | 10 | 40 | 3 | 21211521 |
| Pubmed | CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA. | ZIC1 ZIC2 ZIC3 | 1.68e-07 | 10 | 40 | 3 | 18298960 |
| Pubmed | Spatiotemporal expression of Zic genes during vertebrate inner ear development. | ZIC1 ZIC2 ZIC3 | 1.68e-07 | 10 | 40 | 3 | 23606270 |
| Pubmed | Fibroblast growth factor 8 organizes the neocortical area map and regulates sensory map topography. | ZIC1 ZIC2 ZIC3 | 2.31e-07 | 11 | 40 | 3 | 22623663 |
| Pubmed | Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo. | ZIC1 ZIC2 ZIC3 | 1.14e-06 | 18 | 40 | 3 | 17490632 |
| Pubmed | Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum. | ZIC1 ZIC2 | 1.29e-06 | 2 | 40 | 2 | 25849986 |
| Pubmed | Behavioral abnormalities of Zic1 and Zic2 mutant mice: implications as models for human neurological disorders. | ZIC1 ZIC2 | 1.29e-06 | 2 | 40 | 2 | 11699604 |
| Pubmed | Zic-Proteins Are Repressors of Dopaminergic Forebrain Fate in Mice and C. elegans. | ZIC1 ZIC2 | 1.29e-06 | 2 | 40 | 2 | 28972122 |
| Pubmed | Transcription factors Zic1 and Zic2 bind and transactivate the apolipoprotein E gene promoter. | ZIC1 ZIC2 | 1.29e-06 | 2 | 40 | 2 | 11038359 |
| Pubmed | Lack of association between ZIC2 and ZIC3 genes and the risk of neural tube defects (NTDs) in Hispanic populations. | ZIC2 ZIC3 | 1.29e-06 | 2 | 40 | 2 | 12522805 |
| Pubmed | ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency. | ZIC2 ZIC3 | 1.29e-06 | 2 | 40 | 2 | 39358345 |
| Pubmed | Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly. | ZIC1 ZIC2 ZIC3 | 2.14e-06 | 22 | 40 | 3 | 18448648 |
| Pubmed | Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors. | ZIC1 ZIC2 ZIC3 | 3.18e-06 | 25 | 40 | 3 | 17507568 |
| Pubmed | Expression of ZIC family genes in meningiomas and other brain tumors. | ZIC1 ZIC2 | 3.87e-06 | 3 | 40 | 2 | 20199689 |
| Pubmed | Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets. | ZIC1 ZIC2 | 3.87e-06 | 3 | 40 | 2 | 20676059 |
| Pubmed | SUMOylation Potentiates ZIC Protein Activity to Influence Murine Neural Crest Cell Specification. | ZIC2 ZIC3 | 7.73e-06 | 4 | 40 | 2 | 34638777 |
| Pubmed | Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family. | ZIC1 ZIC2 | 1.93e-05 | 6 | 40 | 2 | 15465018 |
| Pubmed | Distribution of a reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler mice. | ZIC1 ZIC3 | 2.70e-05 | 7 | 40 | 2 | 8863127 |
| Pubmed | Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors. | ZIC2 ZIC3 | 2.70e-05 | 7 | 40 | 2 | 35817961 |
| Pubmed | Localization of Tfap2β, Casq2, Penk, Zic1, and Zic3 Expression in the Developing Retina, Muscle, and Sclera of the Embryonic Mouse Eye. | ZIC1 ZIC3 | 3.60e-05 | 8 | 40 | 2 | 31638440 |
| Pubmed | Identification of reference genes suitable for RT-qPCR studies of murine gastrulation and patterning. | ZIC1 ZIC2 | 3.60e-05 | 8 | 40 | 2 | 30094508 |
| Pubmed | The role of Zic genes in inner ear development in the mouse: Exploring mutant mouse phenotypes. | ZIC1 ZIC2 | 4.62e-05 | 9 | 40 | 2 | 25178196 |
| Pubmed | Zic2 controls cerebellar development in cooperation with Zic1. | ZIC1 ZIC2 | 7.05e-05 | 11 | 40 | 2 | 11756505 |
| Pubmed | FGF8 signaling patterns the telencephalic midline by regulating putative key factors of midline development. | ZIC1 ZIC2 | 7.05e-05 | 11 | 40 | 2 | 18547559 |
| Pubmed | Role of Pax6 in development of the cerebellar system. | ZIC1 ZIC2 | 7.05e-05 | 11 | 40 | 2 | 10409504 |
| Pubmed | Deletion of CHD8 in cerebellar granule neuron progenitors leads to severe cerebellar hypoplasia, ataxia, and psychiatric behavior in mice. | ZIC1 ZIC2 | 1.16e-04 | 14 | 40 | 2 | 35231638 |
| Pubmed | New semidominant mutations that affect mouse development. | ZIC2 ZIC3 | 1.53e-04 | 16 | 40 | 2 | 15384171 |
| Pubmed | Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice. | ZIC1 ZIC2 | 1.73e-04 | 17 | 40 | 2 | 22578469 |
| Pubmed | Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain. | ZIC1 ZIC3 | 1.73e-04 | 17 | 40 | 2 | 26025376 |
| Pubmed | Ipsilateral and Contralateral Retinal Ganglion Cells Express Distinct Genes during Decussation at the Optic Chiasm. | ZIC1 ZIC2 | 1.95e-04 | 18 | 40 | 2 | 27957530 |
| Pubmed | Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip. | ZIC1 ZIC2 | 1.95e-04 | 18 | 40 | 2 | 31869353 |
| Pubmed | Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. | ZNF224 ZNF222 | 2.42e-04 | 20 | 40 | 2 | 12743021 |
| Pubmed | Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development. | ZIC1 ZIC3 | 3.21e-04 | 23 | 40 | 2 | 16893423 |
| Pubmed | Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord. | ZIC1 ZIC2 | 3.80e-04 | 25 | 40 | 2 | 15229182 |
| Pubmed | Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. | ZIC2 ZIC3 | 4.12e-04 | 26 | 40 | 2 | 22992956 |
| Pubmed | A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. | ZIC1 ZIC2 | 4.12e-04 | 26 | 40 | 2 | 19850029 |
| Pubmed | Integrative genomic analysis of early neurogenesis reveals a temporal genetic program for differentiation and specification of preplate and Cajal-Retzius neurons. | ZIC1 ZIC2 | 4.45e-04 | 27 | 40 | 2 | 33760820 |
| Pubmed | The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development. | ZIC1 ZIC3 | 4.78e-04 | 28 | 40 | 2 | 32868762 |
| Pubmed | Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. | ZMAT4 ZIC2 | 5.13e-04 | 29 | 40 | 2 | 23396134 |
| Pubmed | Identification of genes expressed preferentially in the developing peripheral margin of the optic cup. | ZIC1 ZIC2 | 1.08e-03 | 42 | 40 | 2 | 19449303 |
| Interaction | FLT3 interactions | USP17L21 USP17L19 USP17L12 USP17L17 USP17L20 USP17L11 USP17L18 | 8.51e-07 | 318 | 34 | 7 | int:FLT3 |
| Interaction | USP17L7 interactions | USP17L7 USP17L2 | 4.13e-05 | 6 | 34 | 2 | int:USP17L7 |
| Interaction | USP17L9P interactions | USP17L7 USP17L2 | 1.23e-04 | 10 | 34 | 2 | int:USP17L9P |
| Cytoband | 4p16.1 | USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18 | 4.75e-27 | 79 | 40 | 13 | 4p16.1 |
| Cytoband | Ensembl 112 genes in cytogenetic band chr4p16 | USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18 | 5.94e-21 | 222 | 40 | 13 | chr4p16 |
| Cytoband | 8p23.1 | USP17L7 USP17L3 USP17L4 USP17L2 USP17L1 USP17L8 | 4.51e-09 | 154 | 40 | 6 | 8p23.1 |
| Cytoband | Ensembl 112 genes in cytogenetic band chr8p23 | USP17L7 USP17L3 USP17L4 USP17L2 USP17L1 USP17L8 | 5.46e-08 | 234 | 40 | 6 | chr8p23 |
| GeneFamily | Zinc fingers C2H2-type|ZF class homeoboxes and pseudogenes | ZNF711 ZNF823 ZNF485 ZNF836 ZNF573 ZNF224 ZNF560 ZNF679 ZNF335 ZIC1 ZNF222 ZIC2 ZIC3 | 1.20e-14 | 718 | 19 | 13 | 28 |
| Coexpression | MADAN_DPPA4_TARGETS | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 1.71e-35 | 86 | 39 | 18 | MM1312 |
| Coexpression | GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 3.11e-33 | 112 | 39 | 18 | MM1095 |
| Coexpression | GERY_CEBP_TARGETS | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 2.89e-30 | 160 | 39 | 18 | MM1155 |
| Coexpression | GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 3.53e-19 | 647 | 39 | 18 | MM981 |
| Coexpression | MARSON_BOUND_BY_FOXP3_STIMULATED | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 2.46e-15 | 1072 | 39 | 18 | MM1031 |
| Coexpression | BRUINS_UVC_RESPONSE_LATE | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 1.67e-14 | 1198 | 39 | 18 | MM1062 |
| Coexpression | GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L13 USP17L18 | 2.49e-14 | 1226 | 39 | 18 | MM979 |
| CoexpressionAtlas | FacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_100 | ZMAT4 ZIC1 ZIC2 | 8.49e-05 | 97 | 19 | 3 | Facebase_RNAseq_e8.5_Paraxial Mesoderm_100 |
| CoexpressionAtlas | FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_100 | ZIC1 ZIC2 ZIC3 | 9.30e-05 | 100 | 19 | 3 | Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_100 |
| CoexpressionAtlas | FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_100 | ZIC1 ZIC2 ZIC3 | 9.30e-05 | 100 | 19 | 3 | Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_100 |
| CoexpressionAtlas | DevelopingGonad_e11.5_testes_emap-3226_k-means-cluster#4_top-relative-expression-ranked_200 | ZIC1 ZIC3 | 1.43e-04 | 20 | 19 | 2 | gudmap_developingGonad_e11.5_testes_k4_200 |
| CoexpressionAtlas | DevelopingGonad_e11.5_ovary + mesonephros_emap-3226_k-means-cluster#4_top-relative-expression-ranked_200 | ZIC1 ZIC3 | 2.25e-04 | 25 | 19 | 2 | gudmap_developingGonad_e11.5_ovary + mesonephros_k4_200 |
| ToppCell | TCGA-Brain-Recurrent_Tumor-Low_Grade_Glioma-Oligoastrocytoma-3|TCGA-Brain / Sample_Type by Project: Shred V9 | USP17L7 USP17L3 USP17L2 ZIC3 | 1.05e-06 | 104 | 33 | 4 | 1360c9fcb9a68b385aa28dabd0715e71c4867a5b |
| ToppCell | 5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract | ZMAT4 STAB2 ZNF560 ZIC1 | 8.67e-06 | 177 | 33 | 4 | 76f5df101c693e5fa61554244d877fc8169ee66f |
| ToppCell | TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Mixed_Serous_and_Endometrioid-1|TCGA-Endometrium / Sample_Type by Project: Shred V9 | ZMAT4 ZNF560 ZIC3 | 8.39e-05 | 115 | 33 | 3 | c724e8b1fddcefdaa8d247aaff68c986538068f7 |
| ToppCell | Thalamus|World / BrainAtlas - Mouse McCarroll V32 | ZIC1 ZIC2 ZIC3 | 8.61e-05 | 116 | 33 | 3 | 5ddfb2dd5459ff6d7ae38163a38eae64fda283b7 |
| Disease | primary ovarian insufficiency (implicated_via_orthology) | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 7.72e-45 | 46 | 40 | 19 | DOID:5426 (implicated_via_orthology) |
| Disease | congenital heart disease (implicated_via_orthology) | USP17L7 USP17L3 USP17L5 USP17L21 USP17L10 USP17L4 USP17L19 USP17L2 USP17L12 USP17L1 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L8 USP17L24 USP17L13 USP17L18 | 8.47e-41 | 69 | 40 | 19 | DOID:1682 (implicated_via_orthology) |
| Disease | Anorectal Malformations | DESI2 ZIC3 | 1.42e-03 | 41 | 40 | 2 | C3495676 |
| Disease | cholesteryl esters to total lipids in medium VLDL percentage | TENT4A ZNF335 | 3.43e-03 | 64 | 40 | 2 | EFO_0022253 |
