Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalmodulin-dependent protein phosphatase activity

PPP3CA PPP3CC

7.68e-055562GO:0033192
GeneOntologyMolecularFunctionphosphatidylethanolamine flippase activity

ABCA4 ATP11A

1.61e-047562GO:0090555
GeneOntologyMolecularFunctioncalcium-dependent protein serine/threonine phosphatase activity

PPP3CA PPP3CC

2.14e-048562GO:0004723
GeneOntologyMolecularFunctiontranscription coactivator binding

GATA1 CREBBP EPAS1

4.68e-0454563GO:0001223
GeneOntologyMolecularFunctionglycerophospholipid flippase activity

ABCA4 ATP11A

6.88e-0414562GO:0140333
GeneOntologyCellularComponentcalcineurin complex

PPP3CA PPP3CC

1.13e-046582GO:0005955
DomainGAIN_dom_N

CELSR2 ADGRL2

5.12e-0411582IPR032471
DomainGAIN

CELSR2 ADGRL2

5.12e-0411582PF16489
DomainSer/Thr-sp_prot-phosphatase

PPP3CA PPP3CC

7.23e-0413582IPR006186
DomainSER_THR_PHOSPHATASE

PPP3CA PPP3CC

7.23e-0413582PS00125
DomainPP2Ac

PPP3CA PPP3CC

7.23e-0413582SM00156
DomainZinc_finger_PHD-type_CS

TRIM33 KDM7A KDM5D

1.08e-0365583IPR019786
DomainPHD

TRIM33 KDM7A KDM5D

1.64e-0375583PF00628
DomainZnf_PHD-finger

TRIM33 KDM7A KDM5D

1.90e-0379583IPR019787
DomainJmjC

KDM7A KDM5D

2.50e-0324582PF02373
DomainPHD

TRIM33 KDM7A KDM5D

2.67e-0389583SM00249
DomainHormR

CELSR2 ADGRL2

2.72e-0325582SM00008
DomainZnf_PHD

TRIM33 KDM7A KDM5D

2.84e-0391583IPR001965
DomainZF_PHD_2

TRIM33 KDM7A KDM5D

3.21e-0395583PS50016
DomainZF_PHD_1

TRIM33 KDM7A KDM5D

3.31e-0396583PS01359
DomainCalcineurin-like_PHP_ApaH

PPP3CA PPP3CC

3.40e-0328582IPR004843
DomainMetallophos

PPP3CA PPP3CC

3.40e-0328582PF00149
DomainHRM

CELSR2 ADGRL2

3.40e-0328582PF02793
DomainMetallo-depent_PP-like

PPP3CA PPP3CC

3.90e-0330582IPR029052
Domain-

PPP3CA PPP3CC

3.90e-03305823.60.21.10
DomainEGF_LAM_2

LAMB4 CELSR2

3.90e-0330582PS50027
DomainEGF_LAM_1

LAMB4 CELSR2

3.90e-0330582PS01248
DomainAbhydrolase_1

SERHL2 PPME1

4.16e-0331582PF00561
DomainJMJC

KDM7A KDM5D

4.43e-0332582PS51184
DomainJmjC_dom

KDM7A KDM5D

4.43e-0332582IPR003347
DomainJmjC

KDM7A KDM5D

4.70e-0333582SM00558
DomainAB_hydrolase_1

SERHL2 PPME1

4.70e-0333582IPR000073
DomainGPS

CELSR2 ADGRL2

4.99e-0334582SM00303
DomainGPS

CELSR2 ADGRL2

5.28e-0335582PF01825
DomainLaminin_EGF

LAMB4 CELSR2

5.28e-0335582PF00053
DomainEGF_Lam

LAMB4 CELSR2

5.28e-0335582SM00180
DomainGPS

CELSR2 ADGRL2

5.58e-0336582PS50221
DomainGPS

CELSR2 ADGRL2

5.89e-0337582IPR000203
DomainBROMODOMAIN_1

TRIM33 CREBBP

5.89e-0337582PS00633
DomainEGF

RELN FCGBP CELSR2 TNR

6.09e-03235584SM00181
DomainBromodomain

TRIM33 CREBBP

6.20e-0338582PF00439
DomainLAM_G_DOMAIN

CELSR2 COL27A1

6.20e-0338582PS50025
DomainLaminin_EGF

LAMB4 CELSR2

6.20e-0338582IPR002049
DomainG_PROTEIN_RECEP_F2_1

CELSR2 ADGRL2

6.85e-0340582PS00649
DomainGPCR_2_extracellular_dom

CELSR2 ADGRL2

6.85e-0340582IPR001879
DomainG_PROTEIN_RECEP_F2_3

CELSR2 ADGRL2

6.85e-0340582PS50227
DomainBROMODOMAIN_2

TRIM33 CREBBP

7.19e-0341582PS50014
DomainEGF-like_dom

RELN FCGBP CELSR2 TNR

7.45e-03249584IPR000742
DomainBROMO

TRIM33 CREBBP

7.54e-0342582SM00297
PathwayBIOCARTA_MEF2D_PATHWAY

PPP3CA PPP3CC CABIN1

1.77e-0516463MM1483
PathwayBIOCARTA_MEF2D_PATHWAY

PPP3CA PPP3CC CABIN1

2.56e-0518463M5290
PathwayWP_CALCIUM_MEDIATED_TCELL_APOPTOSIS_INVOLVED_IN_INCLUSION_BODY_MYOSITIS

PPP3CA PPP3CC CABIN1

3.57e-0520463M48330
PathwayBIOCARTA_HDAC_PATHWAY

PPP3CA PPP3CC CABIN1

7.11e-0525463M1547
PathwayKEGG_LONG_TERM_POTENTIATION

CACNA1C PPP3CA PPP3CC CREBBP

7.77e-0570464M3115
PathwayBIOCARTA_HDAC_PATHWAY

PPP3CA PPP3CC CABIN1

8.02e-0526463MM1371
PathwayWP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR

PPP3CA PPP3CC CREBBP

1.51e-0432463M39521
PathwayKEGG_ECM_RECEPTOR_INTERACTION

LAMB4 RELN ITGA2B TNR

1.58e-0484464M7098
PathwayKEGG_MEDICUS_REFERENCE_LYSOSOMAL_CA2_RELEASE

PPP3CA PPP3CC

4.61e-0410462M47954
PathwayBIOCARTA_NFAT_PATHWAY

PPP3CA PPP3CC CREBBP

5.39e-0449463MM1442
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR

CREBBP EPAS1

5.62e-0411462M26924
PathwayBIOCARTA_NFAT_PATHWAY

PPP3CA PPP3CC CREBBP

6.07e-0451463M2288
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_CN_SIGNALING_PATHWAY

PPP3CA PPP3CC

6.73e-0412462M47956
PathwayPID_NFAT_3PATHWAY

PPP3CA CABIN1 CREBBP

6.80e-0453463M113
PathwayBIOCARTA_PGC1A_PATHWAY

PPP3CA PPP3CC

9.25e-0414462MM1473
PathwayBIOCARTA_PGC1A_PATHWAY

PPP3CA PPP3CC

1.06e-0315462M15181
PathwayBIOCARTA_NDKDYNAMIN_PATHWAY

PPP3CA PPP3CC

1.06e-0315462MM1387
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_CALCINEURIN_SIGNALING_PATHWAY

PPP3CA PPP3CC

1.21e-0316462M47449
PathwayREACTOME_ZYGOTIC_GENOME_ACTIVATION_ZGA

TUT4 CREBBP

1.37e-0317462M48025
PathwayKEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAQ_PLCB_G_CALCINEURIN

PPP3CA PPP3CC

1.37e-0317462M47560
PathwayBIOCARTA_NDKDYNAMIN_PATHWAY

PPP3CA PPP3CC

1.37e-0317462M5940
PathwayBIOCARTA_CALCINEURIN_PATHWAY

PPP3CA PPP3CC

1.54e-0318462M3430
PathwayKEGG_MEDICUS_REFERENCE_BCR_PLCG_CALCINEURIN_SIGNALING_PATHWAY

PPP3CA PPP3CC

1.54e-0318462M47580
PathwayBIOCARTA_CALCINEURIN_PATHWAY

PPP3CA PPP3CC

1.54e-0318462MM1385
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

PPP3CA PPP3CC

1.72e-0319462M47543
PathwayWP_ALZHEIMERS_DISEASE

CACNA1C PPP3CA PPP3CC

1.79e-0374463MM15962
PathwayBIOCARTA_NOS1_PATHWAY

PPP3CA PPP3CC

1.91e-0320462MM1445
PathwayWP_PYRIMIDINE_METABOLISM_AND_RELATED_DISEASES

AGXT2 OTC

1.91e-0320462M39765
Pubmed

Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells.

PPP3CA PPP3CC CABIN1

1.76e-08458311714752
Pubmed

Physical and functional interaction between calcineurin and the cardiac L-type Ca2+ channel.

CACNA1C PPP3CA

2.73e-06258219478199
Pubmed

Induction of hyperproliferative fetal megakaryopoiesis by an N-terminally truncated GATA1 mutant.

GATA1 ITGA2B

2.73e-06258219682090
Pubmed

Tachypacing-induced CREB/CD44 signaling contributes to the suppression of L-type calcium channel expression and the development of atrial remodeling.

CACNA1C CREBBP

8.19e-06358234023501
Pubmed

The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT.

PPP3CA CABIN1

8.19e-06358215671033
Pubmed

Physical and functional interaction between the transcriptional cofactor CBP and the KH domain protein Sam68.

GATA1 CREBBP

8.19e-06358212496368
Pubmed

TRIM33 protects osteoblasts from oxidative stress-induced apoptosis in osteoporosis by inhibiting FOXO3a ubiquitylation and degradation.

TRIM33 CREBBP

8.19e-06358234101965
Pubmed

Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods.

PPP3CA PPP3CC

8.19e-0635822162844
Pubmed

The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment.

CREBBP EPAS1

8.19e-06358225689462
Pubmed

Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes.

PPP3CA CABIN1

8.19e-0635829655484
Pubmed

The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding.

PPP3CA PPP3CC

8.19e-06358219154138
Pubmed

Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo.

GATA1 ITGA2B

8.19e-06358212393529
Pubmed

Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit.

PPP3CA PPP3CC

8.19e-0635821659808
Pubmed

The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine.

CREBBP EPAS1

1.64e-05458211983697
Pubmed

CREB binding protein is required for both short-term and long-term memory formation.

CREBBP EPAS1

1.64e-05458220881124
Pubmed

Linkage of the erythroid transcription factor gene (Gf-1) to the proximal region of the X chromosome of mice.

OTC GATA1

1.64e-0545822004781
Pubmed

Mapping acetylation sites in E2A identifies a conserved lysine residue in activation domain 1 that promotes CBP/p300 recruitment and transcriptional activation.

GATA1 CREBBP

1.64e-05458222207202
Pubmed

Molecular and phylogenetic analysis of calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit genes.

PPP3CA PPP3CC

1.64e-0545821318721
Pubmed

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway.

CREBBP EPAS1

1.64e-05458215261140
Pubmed

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

CREBBP EPAS1

1.64e-05458210202154
Pubmed

Partial inversion of gene order within a homologous segment on the X chromosome.

OTC GATA1

1.64e-0545828431636
Pubmed

The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling.

CREBBP EPAS1

2.72e-05558222807441
Pubmed

The mouse scurfy (sf) mutation is tightly linked to Gata1 and Tfe3 on the proximal X chromosome.

OTC GATA1

2.72e-0555827849405
Pubmed

Calcineurin: form and function.

PPP3CA PPP3CC

2.72e-05558211015619
Pubmed

Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults.

PPP3CA PPP3CC

2.72e-05558220593291
Pubmed

Elevated expression of calcineurin subunits during active mineralization of developing mouse molar teeth.

PPP3CA PPP3CC

2.72e-05558222984995
Pubmed

Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages.

GATA1 ITGA2B

2.72e-05558218371378
Pubmed

The mouse homolog of the Wiskott-Aldrich syndrome protein (WASP) gene is highly conserved and maps near the scurfy (sf) mutation on the X chromosome.

OTC GATA1

2.72e-0555828666397
Pubmed

Are calcineurin genes associated with endurance phenotype traits?

PPP3CA PPP3CC

2.72e-05558220107831
Pubmed

The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo.

GATA1 ITGA2B

2.72e-05558215882575
Pubmed

TET1 regulates hypoxia-induced epithelial-mesenchymal transition by acting as a co-activator.

CREBBP EPAS1

4.08e-05658225517638
Pubmed

Genetic analyses of tattered, an X-linked dominant, developmental mouse mutation.

OTC GATA1

4.08e-0565827613037
Pubmed

Mammalian brain phosphoproteins as substrates for calcineurin.

PPP3CA PPP3CC

4.08e-0565826330098
Pubmed

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.

PPP3CA PPP3CC

4.08e-05658210195903
Pubmed

CIB1 is a regulator of pathological cardiac hypertrophy.

CACNA1C PPP3CA

4.08e-05658220639889
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

TRIM33 RELN PPP3CA SPTBN2 PPME1 N4BP2L2 QRICH1 CABIN1 CREBBP NR1D2

4.75e-051285581035914814
Pubmed

The protein serine/threonine phosphatases PP2A, PP1 and calcineurin: A triple threat in the regulation of the neuronal cytoskeleton.

PPP3CA PPP3CC

5.71e-05758228126489
Pubmed

Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL.

GATA1 ITGA2B

5.71e-05758225995324
Pubmed

Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity.

PPP3CA PPP3CC

5.71e-0575828631904
Pubmed

Low affinity Ca2+-binding sites of calcineurin B mediate conformational changes in calcineurin A.

PPP3CA PPP3CC

5.71e-05758211123943
Pubmed

Characterization and mapping of the mouse NDP (Norrie disease) locus (Ndp).

OTC GATA1

5.71e-0575828835523
Pubmed

The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.

PPP3CA CREBBP

7.60e-05858215454081
Pubmed

AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling.

PPP3CA PPP3CC

7.60e-05858217640527
Pubmed

Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.

ABCA4 PPP3CA KDM7A

8.16e-055058324721909
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

TRIM33 EPC2 PPP3CA POLDIP3 GATA1 PPME1 QRICH1 FOXJ3 CREBBP

8.28e-05110358934189442
Pubmed

Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling.

PPP3CA PPP3CC

9.77e-05958222343722
Pubmed

SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.

PPP3CA PPP3CC

9.77e-05958234446558
Pubmed

Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.

RELN SLC12A1 ADGRL2

1.15e-045658323934736
Pubmed

Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.

TRIM33 CREBBP

1.22e-041058216751102
Pubmed

New insights into the man-mouse comparative map of the X chromosome.

OTC GATA1

1.49e-04115828188251
Pubmed

Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands.

GATA1 ITGA2B

1.49e-041158220660741
Pubmed

A forward genetic screen in mice identifies mutants with abnormal cortical patterning.

RELN EFR3A

1.49e-041158223968836
Pubmed

Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program.

TRIM33 CREBBP

1.49e-041158218003620
Pubmed

Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.

TRIM33 DDX50 ADGRL2 EFR3A

1.51e-0416058431678930
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

DDX50 POLDIP3 COL27A1 SPTBN2 RASGEF1C LOXL4

1.76e-0449658631343991
Pubmed

A reassessment of the inhibitory capacity of human FKBP38 on calcineurin.

PPP3CA PPP3CC

1.78e-041258215757646
Pubmed

Cell signaling directing the formation and function of hemogenic endothelium during murine embryogenesis.

GATA1 ITGA2B

1.78e-041258218684862
Pubmed

Identification of the hypoxia-inducible factor 2α nuclear interactome in melanoma cells reveals master proteins involved in melanoma development.

TRIM33 CREBBP EPAS1

1.87e-046658323275444
Pubmed

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

UGT1A1 ADGRL2

2.11e-041358222085899
Pubmed

Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions.

PPP3CA PPP3CC

2.46e-041458228826478
Pubmed

Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients.

PPP3CA PPP3CC

2.83e-041558221047202
Pubmed

Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets.

RELN ITGA2B

3.23e-041658226457609
Pubmed

The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ hematoendothelial progenitors.

GATA1 ITGA2B

3.23e-041658233454424
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

POLDIP3 RASGEF1C FOXJ3 CREBBP

3.34e-0419758420811636
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

PPP3CA PPP3CC DDX50 SPTBN2 PPME1 ADGRL2 CEP55 EFR3A

3.36e-04104958827880917
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

DDX50 POLDIP3 GEMIN5 C1orf94 FMNL1

3.42e-0436158526167880
Pubmed

Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure.

PPP3CA PPP3CC

3.66e-041758224086760
Pubmed

Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library.

OTC USP45

3.66e-04175827808216
Pubmed

Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell function.

GATA1 ITGA2B

4.11e-041858221483770
Pubmed

Smad4 and Trim33/Tif1γ redundantly regulate neural stem cells in the developing cortex.

TRIM33 RELN

4.11e-041858223765158
Pubmed

A genome-wide assessment of variability in human serum metabolism.

UGT1A1 ACAD11

4.59e-041958223281178
Pubmed

Genes, plasticity and mental retardation.

RELN CREBBP

4.59e-041958218329113
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

TRIM33 EPC2 TUT4 ACAD11 ZNRF3 ADGRL2 CREBBP TCTN2

5.06e-04111658831753913
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

TRIM33 ACAD11 POLDIP3 CREBBP

5.23e-0422258437071664
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

TRIM33 EPC2 GEMIN5 CEP76 CREBBP

5.33e-0439858535016035
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

TRIM33 EPC2 QRICH1 ADGRL2 CABIN1 FOXJ3 CREBBP

5.43e-0485758725609649
Pubmed

Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation.

PPP3CA PPP3CC

5.62e-042158231696965
Pubmed

Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium.

GATA1 ITGA2B

6.18e-042258222863011
Pubmed

Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.

PPP3CA PPP3CC

6.76e-042358220379146
Pubmed

Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

TRIM33 ATP11A FOXJ3

7.11e-0410458310470851
Pubmed

Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models.

RELN AHI1

7.37e-042458221821099
Pubmed

Genetic link between renal birth defects and congenital heart disease.

QRICH1 PRDM1

1.00e-032858227002738
Pubmed

Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development.

SLC12A1 EPAS1

1.00e-032858228847650
Pubmed

High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.

LAMB4 RELN

1.15e-033058219401682
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

GATA1 QRICH1 FOXJ3 CREBBP EPAS1 NR1D2

1.16e-0370958622988430
Pubmed

Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.

AHI1 PPP3CA ADGRL2

1.30e-0312858330995482
Pubmed

Reevaluating human gene annotation: a second-generation analysis of chromosome 22.

SERHL2 POLDIP3

1.40e-033358212529303
Pubmed

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.

CELSR2 ADGRL2

1.40e-033358225713288
Pubmed

Joubert Syndrome

AHI1 TCTN2

1.48e-033458220301500
Pubmed

The DNA sequence of human chromosome 22.

SERHL2 ZNRF3 POLDIP3 CABIN1

1.60e-0330058410591208
InteractionNFATC4 interactions

PPP3CA PPP3CC POLDIP3 CREBBP

4.87e-0640574int:NFATC4
GeneFamilyProtein phosphatase catalytic subunits|EF-hand domain containing

PPP3CA PPP3CC

4.04e-0413422693
GeneFamilyPHD finger proteins

TRIM33 KDM7A KDM5D

1.19e-039042388
GeneFamilyPHD finger proteins|Lysine demethylases

KDM7A KDM5D

1.41e-0324422485
CoexpressionGARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP

RELN PPP3CC ZNRF3 N4BP2L2 KDM7A CREBBP

6.44e-07139586M11672
CoexpressionGSE32423_IL7_VS_IL7_IL4_NAIVE_CD8_TCELL_DN

EPC2 PPP3CC GATA1 LOXL4 ATP11A PRDM1

5.33e-06200586M5096
ToppCellCV-Mild-6|Mild / Virus stimulation, Condition and Cluster

ATG4A EPC2 AHI1 CREBBP PRDM1

3.26e-06175585c4d530dbb37942427c9cd0a1533faeb6a3a45381
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 FCGBP LOXL4 ADARB2

2.50e-051305847d4319aae42acc914757796877b8f0d874acbec4
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

UGT1A1 RELN LOXL4 VGLL1

5.77e-05161584da9eecf919866a9c579d7a707a996cf335213134
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

UGT1A1 RELN LOXL4 VGLL1

5.77e-05161584d431625c32f59a6b552191f3adc5198bd16ad5cf
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Cerebellum / BrainAtlas - Mouse McCarroll V32

SPTBN2 ADARB2 FMNL1 EFR3A

6.64e-051675849efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCellCerebellum-Neuronal-Inhibitory|Cerebellum / BrainAtlas - Mouse McCarroll V32

SPTBN2 ADARB2 FMNL1 EFR3A

6.64e-05167584904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 FCGBP ZNRF3 ADARB2

7.12e-051705845d5f208682be21ed58320f5fc083a7898f8712da
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LAMB4 LOXL4 ADARB2 EPAS1

7.12e-051705840cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTC GEMIN5 LOXL4 KDM5D

7.12e-0517058445de83a2231208b8e1f21061d0b91644b4a3ba93
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LAMB4 LOXL4 ADARB2 EPAS1

7.12e-051705842d880223d01bde4bf777bd6f50b7d2768489075f
ToppCellASK440-Epithelial-Transformed_epithelium|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

CELSR2 ZNRF3 POLDIP3 LOXL4

7.45e-05172584df3800bcd9777d02900eba0cfc26ab73de8a1d95
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ACAD11 PPME1 CEP76 TNR

7.62e-0517358412f779b8dce79431b2d1002ba524dd3f9566aeb0
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 FCGBP LOXL4 ADARB2

8.69e-0517958455bc69f107fc710db7617c428575792adfdbbcc1
ToppCell3'_v3-bone_marrow-Mast|bone_marrow / Manually curated celltypes from each tissue

SPTBN2 GATA1 ITGA2B EPAS1

8.88e-05180584b37ee81b792213d6595b4ec65d04bc35d83321c7
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RASGEF1C EXTL1 ADGRL2 FMNL1

9.07e-0518158458f76bb9ea1518c2b629a0256a3f6595a9278152
ToppCell3'_v3-bone_marrow-Mast-Mast_cells|bone_marrow / Manually curated celltypes from each tissue

SPTBN2 GATA1 ITGA2B EPAS1

9.07e-0518158430ec4635474ee0f0ea1415ec0ba7f008d97e8c1a
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D175|Adult / Lineage, Cell type, age group and donor

ITGA2B ADGRL2 TNR EPAS1

9.27e-051825848b4a07ebd7a133a33ef333cfa29d12c4f3d4d9ac
ToppCellPosterior_cortex-Neuronal-Excitatory|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PPP3CA SPTBN2 EXTL1 FMNL1

9.67e-0518458425ccf08a8a26d7e7827b6357f33a53aaf423577d
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN GATA1 RASGEF1C ITGA2B

9.67e-05184584e33bb572af9dfd11127105f1ac99bc958a7cafbb
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PPP3CA EXTL1 ADGRL2 FMNL1

1.01e-0418658456c139e679d640ea901ead657a8e8887e0fca098
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 FCGBP ZNRF3 ADARB2

1.03e-04187584c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 LOXL4 ITGA2B VGLL1

1.03e-041875849225caf66e06ebe57e90d677122acb6498607f36
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 ZNRF3 ATP11A ADARB2

1.05e-04188584af740fa78542438fdff627ea1f74f4eee43316be
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 FCGBP ZNRF3 ADARB2

1.09e-041905841cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 FCGBP ZNRF3 ADARB2

1.09e-0419058459bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCellControl-Fibroblasts-Vascular_smooth_muscle|Control / group, cell type (main and fine annotations)

CACNA1C ADGRL2 ADARB2 EPAS1

1.16e-0419358460e44aac8be0430ad35e20eb98b1b700d76a0427
ToppCellwk_08-11-Hematologic-Meg-ery-Definitive_erythroblast|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

RELN GATA1 KDM7A KDM5D

1.16e-04193584be75abfdf5301cf33df8ee9ed92504d44fdf19a6
ToppCellCOVID-19-kidney-FLT1+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

CACNA1C ADGRL2 EPAS1 PRDM1

1.16e-04193584479abb1cd2eb978b8a4fdb900069a6329fc8cade
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FCGBP CELSR2 SPTBN2 ATP11A

1.16e-0419358422ebc3f586eb0aabc5785e468c88d7416c624ff4
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FCGBP CELSR2 RASGEF1C ATP11A

1.19e-041945840ef63abcfd057079a9a6f8b27404ff521d44845d
ToppCellNS-control-d_0-4-Lymphoid-NKT|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PPP3CC FEM1A FMNL1

1.23e-047458397f456f67a698bbf18418d20fc348dbb3f716889
ToppCelldroplet-Mammary_Gland-nan-18m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FCGBP CELSR2 RASGEF1C ATP11A

1.26e-04197584ed3a37f532741764060d297a560eeeeec279d9c4
ToppCell10x5'v1-week_12-13-Hematopoietic|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

RELN GATA1 PPME1 ITGA2B

1.28e-04198584d02e1ff7f68dedaca1e367c7cade772e7b355f45
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 FCGBP SLC12A1 ATP11A

1.31e-041995842e7f517c0444b4f29ff11c26ab32e9cc0f7e99ef
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

TUT4 PPP3CA ADGRL2 EPAS1

1.33e-04200584dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellCOVID-19-Fibroblasts-Vascular_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

CACNA1C ADGRL2 ADARB2 EPAS1

1.33e-04200584c7f82196a0768ad96b1df8b8915bc541fb118a76
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

TUT4 PPP3CA ADGRL2 EPAS1

1.33e-04200584b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
DrugLX201

PPP3CA PPP3CC CABIN1

6.26e-084583CID006440291
Drugsuppressor of FK506 1

PPP3CA PPP3CC CABIN1

6.26e-084583CID000419462
Drugbotrydial

PPP3CA PPP3CC CABIN1

1.56e-075583CID000185781
Drug2,2,2-trifluoroethyl phosphate

PPP3CA PPP3CC CABIN1

5.45e-077583CID000151044
Drug1-benzothiophene-2-carboxamide

PPP3CA PPP3CC CABIN1

5.45e-077583CID000237073
Drugendothall thioanhydride

PPP3CA PPP3CC CABIN1

3.40e-0612583CID000176108
Drug1-norokadaone

PPP3CA PPP3CC CABIN1

3.40e-0612583CID003309928
DrugINCA-6

PPP3CA PPP3CC CABIN1

3.40e-0612583CID000230748
DrugNSC190421

CACNA1C PPP3CA PPP3CC CABIN1

1.01e-0553584CID000002545
Drugcreatinine

AGXT2 ABCA4 PPP3CA PPP3CC SLC12A1 ACAD11 CABIN1

1.14e-05302587CID000000588
Drug4-(fluoromethyl)phenyl phosphate

PPP3CA PPP3CC CABIN1

1.25e-0518583CID000192584
DrugAC1L1G32

PPP3CA PPP3CC CABIN1

1.48e-0519583CID000003504
DrugL-685-818

PPP3CA PPP3CC CABIN1

2.33e-0522583CID000003850
DrugAC1O5U0X

PPP3CA PPP3CC CABIN1

3.06e-0524583CID006440684
Drugh EIT

PPP3CA PPP3CC CABIN1

3.47e-0525583CID000452078
DrugLuveniq

PPP3CA PPP3CC CABIN1

3.47e-0525583CID006918486
Drugcantharidic acid

PPP3CA PPP3CC CABIN1

5.47e-0529583CID000002544
Drugirinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A

TRIM33 AHI1 ADGRL2 FOXJ3 CREBBP

8.13e-051745857530_DN
DrugH944

UGT1A1 PPP3CA PPP3CC CABIN1

8.96e-0592584CID000004271
Drug4-nitro-phen-yl

PPP3CA PPP3CC POLDIP3 CABIN1

9.35e-0593584CID000119211
Drugendothall

PPP3CA PPP3CC CABIN1

1.06e-0436583CID000003225
Drugfenvalerate

PPP3CA PPP3CC CABIN1 PRDM1

1.06e-0496584CID000003347
DrugAC1O5KXC

PPP3CA PPP3CC CABIN1

1.15e-0437583CID006436011
Diseaseschizophrenia (is_marker_for)

RELN PPP3CA PPP3CC

7.28e-0544543DOID:5419 (is_marker_for)
DiseaseN2,N2-dimethylguanosine measurement

AGXT2 LOXL4

9.14e-058542EFO_0021125
Diseasegranulins measurement

CELSR2 ITGA2B

2.14e-0412542EFO_0008141
DiseaseMeckel-Gruber syndrome

TCTN2 CEP55

3.40e-0415542C0265215
Diseasemyelodysplastic syndrome (implicated_via_orthology)

GATA1 CREBBP

3.40e-0415542DOID:0050908 (implicated_via_orthology)
DiseaseFamilial aplasia of the vermis

AHI1 TCTN2

6.12e-0420542cv:C0431399
DiseaseNeutropenia

UGT1A1 GATA1

6.75e-0421542C0027947
DiseaseJoubert syndrome 1

AHI1 TCTN2

6.75e-0421542C4551568
Diseaseosteoarthritis

RELN PPP3CA COL27A1 ADARB2

7.35e-04222544MONDO_0005178
Diseaseprogranulin measurement

CELSR2 ITGA2B

7.42e-0422542EFO_0004625
DiseaseHodgkin Disease

UGT1A1 RELN

7.42e-0422542C0019829
DiseaseInvolutional paraphrenia

CACNA1C RELN

9.60e-0425542C1571983
DiseasePsychosis, Involutional

CACNA1C RELN

9.60e-0425542C1571984
DiseaseInvolutional Depression

CACNA1C RELN

9.60e-0425542C0011574
Diseasethrombocytopenia (is_implicated_in)

GATA1 ITGA2B

1.12e-0327542DOID:1588 (is_implicated_in)
DiseaseThrombocytopenia

GATA1 ITGA2B

1.29e-0329542C0040034
DiseaseFamilial aplasia of the vermis

AHI1 TCTN2

1.38e-0330542C0431399
Diseaseserum metabolite measurement

UGT1A1 AGXT2 LAMB4 PPP3CA CELSR2 COL27A1 LOXL4

1.61e-03945547EFO_0005653

Protein segments in the cluster

PeptideGeneStartEntry
QHFNTFGGNPMACAI

AGXT2

376

Q9BYV1
QHCFSAMTNIFQPLA

EPAS1

561

Q99814
PMNNSCLTNAVHLNN

EPC2

721

Q52LR7
NDQTFHCLQSPQRMN

ATG4A

296

Q8WYN0
NISEVHQNMGYCPQF

ABCA4

2006

P78363
HPFENMVAFCAFGQN

AHI1

896

Q8N157
APNCFNSSINNIHEM

CEP55

156

Q53EZ4
TGPGICMNANFNQTH

CREBBP

171

Q92793
CMNANFNQTHPGLLN

CREBBP

176

Q92793
PNLGAGHQLQMCYQI

ADGRL2

1411

O95490
IGCVFNHQMFLGNCQ

CEP76

456

Q8TAP6
NHQMFLGNCQPSDAV

CEP76

461

Q8TAP6
GKSCAQEMANPQHFL

CELSR2

1606

Q9HCU4
QALHPQLGCYSQQVM

C1orf94

496

Q6P1W5
NFVSQMIAVPAFCQH

EFR3A

606

Q14156
FNCQAPDTGNMEVLH

ACAD11

466

Q709F0
AQFMNGNIHIPVAVQ

QRICH1

386

Q2TAL8
QFPNACQAHLAMGGG

ADARB2

191

Q9NS39
QGKFQMQVLPQCGHA

PPME1

336

Q9Y570
DCMAFGGNFLHNLNI

KDM7A

361

Q6ZMT4
AAVRCNVPNMGFQNQ

LOXL4

406

Q96JB6
MFQSGANHVQCNTHP

KDM5D

166

Q9BY66
MSTLNFCGPNVINHF

OR3A1

166

P47881
NGHNFMVRNFRCGQP

OTC

16

P00480
AQGTCVSNVPNHNEM

RELN

1436

P78509
MERNHNPDNCNVLNF

OR1L1

1

Q8NH94
NACGLYHKMNGQNRP

GATA1

226

P15976
CHQQQLQNPAEEGMS

CABIN1

866

Q9Y6J0
AHANMNANAAAGLAP

CACNA1C

26

Q13936
LCGNMDRNPNNDQVF

FCGBP

4216

Q9Y6R7
SNVQQNVCHGAMHPT

FOXJ3

526

Q9UPW0
HIAAQNNCPAIMNAL

FEM1A

586

Q9BSK4
AMNPHIKQNAQCLHG

DDX50

406

Q9BQ39
KMNPHAVQFEGALCQ

COL27A1

201

Q8IZC6
QSGFSLVMNHPACVN

FMNL1

241

O95466
QLHNCVEIASAMGPQ

LAMB4

731

A4D0S4
QFQFVEVPGNHCVHM

SERHL2

276

Q9H4I8
MNQQFLCVHGGLSPE

PPP3CA

191

Q08209
NNVMNIRQFNCSPHP

PPP3CA

326

Q08209
CNLHMNGNVITSDQP

POLDIP3

346

Q9BY77
PNGHAICIANGHCMN

NR1D2

331

Q14995
NCGAFQAHQMRLAQN

TRIM33

581

Q9UPN9
RHEPCQYGLMNNFQV

SLC12A1

471

Q13621
HSPREQNLAACQNGM

PRDM1

166

O75626
FNIQMCVGATGHNIP

ITGA2B

516

P08514
APDCINQIAAAFGHM

EXTL1

631

Q92935
ADNAMNQCPVHFIQH

ATP11A

121

P98196
ENNVMNIRQFNCSPH

PPP3CC

321

P48454
IQQGMVAHACNPNTL

ZNF714

501

Q96N38
GNTCFFNAVMQNLAQ

USP45

196

Q70EL2
CQMKTAGYPNVNVHN

SPTBN2

186

O15020
FILEHQMDPTGNFCN

RASGEF1C

326

Q8N431
RSHFPGCLAQEMQQQ

GEMIN5

1471

Q8TEQ6
VFPHPQDCAQHLMNG

TNR

1131

Q92752
NMVFVGGINCLHQNP

UGT1A1

271

P22309
GEIVQMHPLGLCNNN

ZNRF3

96

Q9ULT6
LHQNFMHQGNARFQP

TUT4

1601

Q5TAX3
NCNLHVPGPMAVNQF

VGLL1

101

Q99990
AGQCMQNAPVAFLHN

TCTN2

301

Q96GX1
FPVPNNLHMAQNACE

ZNF891

281

A8MT65
NKAMPSHCDYQQNLG

N4BP2L2

226

Q92802