Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionactin filament binding

FLNC ESPNL GSN SPTBN4 MYO1F CTNNA3 CTNNA1 CTNNA2 PLEC VCL

1.68e-0622712510GO:0051015
GeneOntologyMolecularFunctionankyrin binding

FLNC OBSCN SPTBN4 PLEC

1.18e-05231254GO:0030506
GeneOntologyCellularComponentintercalated disc

OBSCN SPTBN4 CTNNA3 CTNNA1 VCL

5.87e-05681275GO:0014704
GeneOntologyCellularComponentcell-cell contact zone

OBSCN SPTBN4 CTNNA3 CTNNA1 VCL

2.72e-04941275GO:0044291
GeneOntologyCellularComponentcostamere

FLNC PLEC VCL

3.10e-04221273GO:0043034
DomainVINCULIN_1

CTNNA3 CTNNA1 CTNNA2 VCL

1.91e-0941254PS00663
DomainVinculin_CS

CTNNA3 CTNNA1 CTNNA2 VCL

1.91e-0941254IPR000633
DomainVinculin

CTNNA3 CTNNA1 CTNNA2 VCL

9.51e-0951254PF01044
DomainVinculin/catenin

CTNNA3 CTNNA1 CTNNA2 VCL

6.59e-0871254IPR006077
DomainAlpha_catenin

CTNNA3 CTNNA1 CTNNA2

1.16e-0641253IPR001033
DomainCH

CFAP47 FLNC SPTBN4 ASPM PLEC

1.06e-04701255PF00307
Domain-

CFAP47 FLNC SPTBN4 ASPM PLEC

1.13e-047112551.10.418.10
DomainCH

CFAP47 FLNC SPTBN4 ASPM PLEC

1.29e-04731255PS50021
DomainCH-domain

CFAP47 FLNC SPTBN4 ASPM PLEC

1.47e-04751255IPR001715
DomainTyr_kinase_cat_dom

TNK1 SRMS PTK6 MAP3K9 FGFR3

3.11e-04881255IPR020635
DomainTyrKc

TNK1 SRMS PTK6 MAP3K9 FGFR3

3.11e-04881255SM00219
DomainSer-Thr/Tyr_kinase_cat_dom

TNK1 SRMS PTK6 NEK8 MAP3K9 FGFR3

3.33e-041381256IPR001245
DomainNEUZ

NEURL3 NEURL4

4.39e-0451252SM00588
DomainNHR

NEURL3 NEURL4

4.39e-0451252PS51065
DomainNHR_dom

NEURL3 NEURL4

4.39e-0451252IPR006573
DomainNeuralized

NEURL3 NEURL4

4.39e-0451252PF07177
DomainACTININ_2

FLNC SPTBN4 PLEC

4.70e-04231253PS00020
DomainACTININ_1

FLNC SPTBN4 PLEC

4.70e-04231253PS00019
DomainActinin_actin-bd_CS

FLNC SPTBN4 PLEC

4.70e-04231253IPR001589
DomainPROTEIN_KINASE_TYR

TNK1 OBSCN SRMS PTK6 FGFR3

4.88e-04971255PS00109
DomainTyr_kinase_AS

TNK1 OBSCN SRMS PTK6 FGFR3

4.88e-04971255IPR008266
DomainCH

FLNC SPTBN4 ASPM PLEC

9.44e-04651254SM00033
DomainIQ

OBSCN MYO1F ASPM CEP131

1.31e-03711254PF00612
DomainPH_dom-spectrin-type

PSD2 SPTBN4

1.55e-0391252IPR001605
DomainP-loop_NTPase

ERCC2 DHX37 DDX51 NDUFA10 PAPSS2 DIRAS3 SBNO2 SUPV3L1 KIF19 MYO1F ASPM GTPBP3 CHST7 ABCC10

1.62e-0384812514IPR027417
DomainAnkyrin_rpt

INHBC ESPNL ANKRD46 SOWAHA ANKRD34B ASB16 ANKRD52

1.93e-032621257IPR002110
DomainIQ

OBSCN MYO1F ASPM CEP131

2.14e-03811254SM00015
DomainTHAP

THAP8 THAP10

2.81e-03121252SM00980
DomainTHAP

THAP8 THAP10

2.81e-03121252PF05485
DomainZF_THAP

THAP8 THAP10

2.81e-03121252PS50950
DomainDM3

THAP8 THAP10

2.81e-03121252SM00692
DomainZnf_C2CH

THAP8 THAP10

2.81e-03121252IPR006612
DomainIQ_motif_EF-hand-BS

OBSCN MYO1F ASPM CEP131

3.14e-03901254IPR000048
DomainSH3

TNK1 OBSCN SRMS PTK6 MYO1F MAP3K9

3.35e-032161256SM00326
DomainSH3

TNK1 OBSCN SRMS PTK6 MYO1F MAP3K9

3.35e-032161256PS50002
DomainIQ

OBSCN MYO1F ASPM CEP131

3.53e-03931254PS50096
DomainSH3_domain

TNK1 OBSCN SRMS PTK6 MYO1F MAP3K9

3.66e-032201256IPR001452
DomainProtein_kinase_ATP_BS

TNK1 OBSCN SRMS PTK6 CLK2 NEK8 MAP3K9 FGFR3

4.01e-033791258IPR017441
Domain-

ERCC2 DHX37 DDX51 NDUFA10 PAPSS2 DIRAS3 SBNO2 SUPV3L1 MYO1F GTPBP3 CHST7 ABCC10

4.31e-03746125123.40.50.300
DomainAnk

ESPNL ANKRD46 SOWAHA ANKRD34B ASB16 ANKRD52

4.36e-032281256PF00023
PathwayBIOCARTA_CELL2CELL_PATHWAY

CTNNA3 CTNNA1 CTNNA2 VCL

7.07e-0712894M12851
PathwayBIOCARTA_CELL2CELL_PATHWAY

CTNNA1 CTNNA2 VCL

1.99e-059893MM1366
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

VWA5B2 FLNC ERCC2 B4GALNT4 ITPRIPL2 LONRF1 OBSCN THAP8 HUWE1 SBNO2 PIKFYVE SLC38A10 MTOR KLHL21 NEK8 ZNF408 POLL CEP131 PLEC ABCC10

7.43e-0911051322035748872
Pubmed

An autoinhibited structure of α-catenin and its implications for vinculin recruitment to adherens junctions.

CTNNA1 CTNNA2 VCL

5.34e-083132323589308
Pubmed

Leucine zipper domain of HIV-1 gp41 interacted specifically with alpha-catenin.

CTNNA3 CTNNA1 CTNNA2

5.34e-083132311883950
Pubmed

The cytoplasmic domain of HIV-1 gp41 interacts with the carboxyl-terminal region of alpha-catenin.

CTNNA3 CTNNA1 CTNNA2

5.34e-083132310420987
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

CASC3 ASXL1 SRMS HUWE1 PXDN ARHGEF10 WDR6 FGFR3 CTNNA1 BMP8A PLEC

6.30e-083321321137433992
Pubmed

Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways.

CTNNA3 CTNNA1 CTNNA2 VCL

6.41e-0811132414657280
Pubmed

Heterocellular interaction enhances recruitment of alpha and beta-catenins and ZO-2 into functional gap-junction complexes and induces gap junction-dependant differentiation of mammary epithelial cells.

CTNNA3 CTNNA1 CTNNA2

2.13e-074132318775424
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

FLNC COPG1 DHX37 CAPN1 DDX51 HUWE1 MTOR WDR6 CTNNA1 PLEC ANKRD52 VCL RPL15

1.34e-066531321322586326
Pubmed

Adhesion protein VSIG1 is required for the proper differentiation of glandular gastric epithelia.

CTNNA3 CTNNA1 CTNNA2

1.85e-067132321991385
Pubmed

TGF-beta3 is required for the adhesion and intercalation of medial edge epithelial cells during palate fusion.

CTNNA1 CTNNA2 VCL

2.95e-068132312068957
Pubmed

Functional analysis of ectodermal β-catenin during external genitalia formation.

CTNNA3 CTNNA1 CTNNA2

2.95e-068132323480356
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

VWA5B2 PSD2 ZNF862 HSPA12B ZNF529 PTK6 PIKFYVE NEURL4

3.25e-06233132837704626
Pubmed

A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection.

COPG1 CAPN1 RALY SPTBN4 PIGR CEP131 VCL

8.32e-06189132731594818
Pubmed

Dimer asymmetry defines α-catenin interactions.

CTNNA1 VCL

1.43e-052132223292143
Pubmed

LTB4R Promotes the Occurrence and Progression of Clear Cell Renal Cell Carcinoma (ccRCC) by Regulating the AKT/mTOR Signaling Pathway.

LTB4R2 MTOR

1.43e-052132236429034
Pubmed

alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells.

CTNNA1 VCL

1.43e-05213229700171
Pubmed

Cell-cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas.

CTNNA3 CTNNA2

1.43e-052132224100690
Pubmed

A novel FLNC frameshift and an OBSCN variant in a family with distal muscular dystrophy.

FLNC OBSCN

1.43e-052132229073160
Pubmed

αE-catenin is an autoinhibited molecule that coactivates vinculin.

CTNNA3 CTNNA1

1.43e-052132222586082
Pubmed

Monomeric α-catenin links cadherin to the actin cytoskeleton.

CTNNA1 CTNNA2

1.43e-052132223417122
Pubmed

The cytoskeletal protein α-catenin unfurls upon binding to vinculin.

CTNNA1 VCL

1.43e-052132222493458
Pubmed

Identification of a novel cDNA clone encoding protein tyrosine kinase in murine skin.

SRMS PTK6

1.43e-05213227962951
Pubmed

Mechanical instability of adherens junctions overrides intrinsic quiescence of hair follicle stem cells.

CTNNA1 VCL

1.43e-052132233725480
Pubmed

Structural and functional characterization of Kv6.2 a new gamma-subunit of voltage-gated potassium channel.

KCNG2 KCNB1

1.43e-052132210551266
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

C11orf98 FLNC COPG1 DHX37 CAPN1 DDX51 HUWE1 PAPSS2 RALY WDR6 SUPV3L1 ASPM MRPS23 PLEC ANKRD52 VCL RPL15

1.53e-0513531321729467282
Pubmed

XPD codon 751 polymorphism, metabolism genes, smoking, and bladder cancer risk.

NAT2 ERCC2

4.28e-053132212376500
Pubmed

betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system.

SPTBN4 PTPRN2

4.28e-053132211086001
Pubmed

PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment.

PIKFYVE MTOR

4.28e-053132227623384
Pubmed

Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases.

SRMS PTK6

4.28e-053132212725532
Pubmed

Structure of the dimerization and beta-catenin-binding region of alpha-catenin.

CTNNA1 CTNNA2

4.28e-053132210882138
Pubmed

Loss of αT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia.

CTNNA3 CTNNA1

4.28e-053132222421363
Pubmed

α-Catenin and vinculin cooperate to promote high E-cadherin-based adhesion strength.

CTNNA1 VCL

4.28e-053132223266828
Pubmed

Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination.

HUWE1 POLL

4.28e-053132222203964
Pubmed

Polymorphisms at XPD and XRCC1 DNA repair loci and increased risk of oral leukoplakia and cancer among NAT2 slow acetylators.

NAT2 ERCC2

4.28e-053132217290401
Pubmed

Alpha-catenin is essential in intestinal adenoma formation.

CTNNA1 CTNNA2

4.28e-053132217989230
Pubmed

Novel interactions of ankyrins-G at the costameres: the muscle-specific Obscurin/Titin-Binding-related Domain (OTBD) binds plectin and filamin C.

FLNC PLEC

4.28e-053132221223964
Pubmed

CTNNA1 hypermethylation, a frequent event in acute myeloid leukemia, is independently associated with an adverse outcome.

ASXL1 CTNNA1

4.28e-053132227129146
Pubmed

α-Catenin-dependent cytoskeletal tension controls Yap activity in the heart.

CTNNA3 CTNNA1

4.28e-053132229467248
Pubmed

Regulation of oxidative DNA damage repair: the adenine:8-oxo-guanine problem.

HUWE1 POLL

4.28e-053132222370481
Pubmed

Alteration of E-cadherin and alpha N-catenin immunoreactivity in the mouse spinal cord following peripheral axotomy.

CTNNA1 CTNNA2

4.28e-05313229370228
Pubmed

Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.

FLNC OBSCN VCL

4.95e-0519132327171814
Pubmed

Loss of BAF Complex in Developing Cortex Perturbs Radial Neuronal Migration in a WNT Signaling-Dependent Manner.

CTNNA3 CTNNA1 CTNNA2

5.81e-0520132334220450
Pubmed

Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis.

CTNNA3 CTNNA1 CTNNA2

6.76e-0521132319129494
Pubmed

Genome-scale RNAi screen for host factors required for HIV replication.

TNK1 DOCK8-AS1 NR4A2 SRMS NDUFA10 MAP3K9 MED17 PPM1N

7.51e-05361132818976975
Pubmed

Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition.

CTNNA3 CTNNA1 CTNNA2

7.81e-0522132327913639
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

ERCC2 CAND2 COPG1 DCTN5 DHX37 CAPN1 DMAC2 HUWE1 RALY MTOR MRPS23

8.18e-057041321129955894
Pubmed

Aberrant mTOR/autophagy/Nurr1 signaling is critical for TSC-associated tumor development.

NR4A2 MTOR

8.54e-054132234463540
Pubmed

MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways.

MTOR FGFR3

8.54e-054132221383697
Pubmed

Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation.

MTOR VCL

8.54e-054132226359501
Pubmed

Bidirectional transcription from human LRRTM2/CTNNA1 and LRRTM1/CTNNA2 gene loci leads to expression of N-terminally truncated CTNNA1 and CTNNA2 isoforms.

CTNNA1 CTNNA2

8.54e-054132221708131
Pubmed

Identification of enzymes responsible for nitrazepam metabolism and toxicity in human.

NAT2 AOX1

8.54e-054132228606603
Pubmed

Mouse alpha N-catenin: two isoforms, specific expression in the nervous system, and chromosomal localization of the gene.

CTNNA1 CTNNA2

8.54e-05413228174789
Pubmed

Vinculin: a novel marker for quiescent and activated hepatic stellate cells in human and rat livers.

MTOR VCL

8.54e-054132212719976
Pubmed

HER2 regulates Brk/PTK6 stability via upregulating calpastatin, an inhibitor of calpain.

CAPN1 PTK6

8.54e-054132223707532
Pubmed

Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity.

CTNNA3 CTNNA1

8.54e-054132225305307
Pubmed

N-cadherin mediates cortical organization in the mouse brain.

CTNNA1 CTNNA2

8.54e-054132217222817
Pubmed

MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632.

MTOR CTNNA1

8.54e-054132214579029
Pubmed

Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.

FLNC COPG1 CAPN1 GSN RALY CTNNA1 PLEC VCL RPL15

1.08e-04488132931324722
Pubmed

The tale of the long tail: the cytoplasmic domain of HIV-1 gp41.

CTNNA3 CTNNA1 CTNNA2

1.30e-0426132323077317
Pubmed

Epidermal development requires ninein for spindle orientation and cortical microtubule organization.

CTNNA3 CTNNA1 CTNNA2

1.30e-0426132330923192
Pubmed

Differential expression of alpha-E-catenin and alpha-N-catenin in the developing cerebral cortex.

CTNNA1 CTNNA2

1.42e-045132216457793
Pubmed

Animal models of gene-environment interactions in schizophrenia.

DISC1 NR4A2

1.42e-045132219379776
Pubmed

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

CTNNA1 CTNNA2

1.42e-04513222788574
Pubmed

Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.

CTNNA1 CTNNA2

1.42e-04513222349235
Pubmed

Wnt-1-dependent regulation of local E-cadherin and alpha N-catenin expression in the embryonic mouse brain.

CTNNA1 CTNNA2

1.42e-04513227925023
Pubmed

Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase.

SRMS PTK6

1.42e-045132225897081
Pubmed

Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly.

CTNNA1 CTNNA2

1.42e-045132216325583
Pubmed

GDF15 regulates Kv2.1-mediated outward K+ current through the Akt/mTOR signalling pathway in rat cerebellar granule cells.

KCNB1 MTOR

1.42e-045132224597762
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

CAND2 DCTN5 NDUFA10 GSN TULP3 SOWAHA MTOR NEK8 POLL CEP131 CTNNA1 PLEC VPS51 NEURL4 VCL

1.54e-0413211321527173435
Pubmed

Deletion in Catna2, encoding alpha N-catenin, causes cerebellar and hippocampal lamination defects and impaired startle modulation.

CTNNA1 CTNNA2

2.12e-046132212089526
Pubmed

Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics.

PIKFYVE VCL

2.12e-046132220841379
Pubmed

Cadherin-dependent adhesion is required for muscle stem cell niche anchorage and maintenance.

CTNNA3 CTNNA1

2.12e-046132238456551
Pubmed

Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile.

LAMA2 VCL

2.12e-046132222925892
Pubmed

The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren's syndrome.

CTNNA1 CTNNA2

2.12e-046132224080911
Pubmed

Switching of alpha-catenin from alphaE-catenin in the cortical ventricular zone to alphaN-catenin II in the intermediate zone.

CTNNA1 CTNNA2

2.12e-046132216185771
Pubmed

Requirement for N-cadherin-catenin complex in heart development.

CTNNA3 CTNNA1

2.12e-046132221680756
Pubmed

Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1.

PIKFYVE MTOR

2.12e-046132222696681
Pubmed

The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility.

CTNNA1 CTNNA2

2.12e-046132212975353
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

FLNC COPG1 CAPN1 HUWE1 PAPSS2 GSN CTNNA1 PLEC CCDC9 VCL RPL15

2.67e-048071321130575818
Pubmed

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.

NAT2 ERCC2 WNT6 TULP3 NRXN2 FGFR3 VCL

2.83e-04331132720634891
Pubmed

Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.

FLNC COPG1 HUWE1 CTNNA1 CTNNA2 PLEC

2.88e-04235132628378594
Pubmed

The protein tyrosine kinase family of the human genome.

TNK1 SRMS PTK6 FGFR3

2.89e-0483132411114734
Pubmed

The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin.

CTNNA1 CTNNA2

2.97e-047132212808048
Pubmed

Expression and cell membrane localization of catenins during mouse preimplantation development.

CTNNA1 CTNNA2

2.97e-04713228853988
Pubmed

Alpha-E-catenin binds to dynamitin and regulates dynactin-mediated intracellular traffic.

CTNNA1 VCL

2.97e-047132219075109
Pubmed

The tumor-suppressor function of E-cadherin.

CTNNA1 CTNNA2

2.97e-04713229837810
Pubmed

The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration.

CTNNA1 CTNNA2

2.97e-047132212052883
Pubmed

alphaE-catenin is not a significant regulator of beta-catenin signaling in the developing mammalian brain.

CTNNA1 CTNNA2

2.97e-047132218397997
Pubmed

A unique and specific interaction between alphaT-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs.

CTNNA3 CTNNA1

2.97e-047132217535849
Pubmed

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.

ERCC2 HUWE1 DMAP1 CLK2 CEP131

3.43e-04157132530686591
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

DUSP12 FLNC CAND2 COPG1 HUWE1 GSN PTPRN2 MTOR WDR6 CTNNA1 ANKRD52 VCL

3.51e-049741321228675297
Pubmed

Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway.

OBSCN VCL

3.94e-048132228826662
Pubmed

The genes coding for alpha and beta catenin (Catna1 and Catnb) and plakoglobin (Jup) map to mouse chromosomes 18, 9, and 11, respectively.

CTNNA1 CTNNA2

3.94e-04813227626889
Pubmed

Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex.

CTNNA3 CTNNA1 CTNNA2

4.09e-0438132330240734
Pubmed

O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma.

COPG1 RALY SLC38A10 SUPV3L1 MRPS23 CTNNA1

4.35e-04254132636604567
Pubmed

Proteome analysis of the circadian clock protein PERIOD2.

FLNC GSN RALY PLEC

4.64e-0494132435122331
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

ASXL1 COPG1 DCTN5 PAPSS2 RALY PIGR ASPM CEP131 CTNNA1 RTN4RL2 NEURL4 CCDC9 VCL

4.68e-0411551321320360068
Pubmed

Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.

ERCC2 COPG1 WNT6 GSN CTNNA1 CTNNA2

4.82e-0425913269811942
Pubmed

Switching of α-Catenin From Epithelial to Neuronal Type During Lens Epithelial Cell Differentiation.

CTNNA1 CTNNA2

5.06e-049132228692740
Pubmed

Expression of catenins during mouse embryonic development and in adult tissues.

CTNNA1 CTNNA2

5.06e-04913228821035
InteractionMEX3A interactions

CASC3 ASXL1 LAMA2 SRMS HUWE1 PXDN ARHGEF10 WDR6 FGFR3 CTNNA1 BMP8A PLEC

4.91e-0638412512int:MEX3A
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

BRPF3 CAND2 TULP3 ZBTB45 PLEC GTPBP3 PPM1N

1.15e-061821317c98da2db197b1531204e116600ff51891e5c17af
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COPG1 TMPRSS6 HUWE1 PAPSS2 SLC38A10 PTPRN2 WDR6

1.77e-0619413170b023de48ed8a550d169bbe954881eb04bf4f981
ToppCelldroplet-Trachea|droplet / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS6 NR4A2 CAVIN3 PAPSS2 GSN KLHL21 PAM

2.09e-0619913171c7d30765ddb2291967da5d15664c6238c680c1d
ToppCelldroplet-Trachea|droplet / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMPRSS6 NR4A2 CAVIN3 PAPSS2 GSN KLHL21 PAM

2.09e-061991317b9038a1ccf3ef3123e2e39afbe6213c363437443
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AVPR2 P2RY8 SPTBN4 PRELID3A CTNNA2 ABCC10

6.65e-06155131651f6447945389649d99dcf7603b396195c631ead
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic-Mast_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AVPR2 P2RY8 SPTBN4 PRELID3A CTNNA2 ABCC10

6.65e-06155131623dc71cab28094ca0ac4d2baf4e24871ed107781
ToppCellLA-06._Ventricular_Cardiomyocyte_II|LA / Chamber and Cluster_Paper

AVPR2 ZBTB45 CTNNA3 PAM FGFR3

7.78e-06921315fad2e02ae858e3a9bbe51ad1c689f7e31d11ce0e
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|343B / Donor, Lineage, Cell class and subclass (all cells)

BRPF3 CAND2 TULP3 ZBTB45 GTPBP3 PPM1N

1.46e-051781316ec6364432d37a32f5152d36d89f5e96dddb72a9d
ToppCellLV-15._Ventricular_Cardiomyocyte_III|LV / Chamber and Cluster_Paper

FLNC OBSCN LAMA2 CTNNA3 PAM VCL

1.76e-051841316ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

BRPF3 CAND2 COPG1 TULP3 PTPRN2 PLEC

1.88e-051861316bbb8edea8d8bdc1a469faec1563e40b1f62d7f3d
ToppCelldroplet-Pancreas-Endocrine|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COPG1 TMPRSS6 PAPSS2 SLC38A10 PTPRN2 PAM

2.24e-0519213160dfd1e9896c34aee0f842f8de5d0e3af62a15f68
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COPG1 TMPRSS6 PAPSS2 SLC38A10 TRPM5 PTPRN2

2.31e-051931316471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COPG1 TMPRSS6 PAPSS2 SLC38A10 TRPM5 PTPRN2

2.31e-051931316fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCellfacs-Pancreas-Endocrine|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA5B2 COPG1 PAPSS2 PTPRN2 WDR6 PAM

2.31e-05193131615c86e20b97b6983410b36d308cddff56d141c98
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS6 HUWE1 PAPSS2 SLC38A10 KCNB1 PTPRN2

2.45e-0519513163e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS6 HUWE1 PAPSS2 SLC38A10 KCNB1 PTPRN2

2.45e-0519513167796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellfacs-SCAT-Fat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNC TMPRSS6 LAMA2 CAVIN3 GSN PAM

2.52e-05196131665f2f51e17f1869f3468813127b96d3048d8ad41
ToppCellfacs-SCAT-Fat-18m-Mesenchymal-mesenchymal_progenitor|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNC TMPRSS6 LAMA2 CAVIN3 GSN PAM

2.52e-051961316e4ed897900a6472738bc6be2fb4817192727225d
ToppCellfacs-SCAT-Fat-18m-Mesenchymal|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNC TMPRSS6 LAMA2 CAVIN3 GSN PAM

2.52e-0519613162cd83176f2e8a9e6fa3c08cb33928a61e5fc43b6
ToppCellFibroblasts-DKK3+_Fibroblasts|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

FLNC LAMA2 CAVIN3 PXDN ARHGEF10 PAM

2.67e-0519813164f4632f26a2043c5e4ab89031b4229b5dca1bd48
ToppCellTracheal-10x3prime_v2-Stromal-Schwann-Schwann_nonmyelinating|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CAND2 WNT6 PRELID3A ARHGEF10 ANKRD52 VCL

2.74e-051991316a92718a3f1153b8d2196fd343ed5bc0ebc98cad7
ToppCellTracheal-10x3prime_v2-Stromal-Schwann|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CAND2 WNT6 PRELID3A ARHGEF10 ANKRD52 VCL

2.74e-0519913168dc65662c3ca1db2ba0091332f0658abc0afc5de
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Grp_(Neuron.Slc17a6.Grp)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

ESPNL TRPM5 PIGR BMP8A

4.05e-05651314b7bc23af54d6d2f7afd584f4df42c24d7c49e344
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Grp_(Neuron.Slc17a6.Grp)|Hippocampus / BrainAtlas - Mouse McCarroll V32

ESPNL TRPM5 PIGR BMP8A

4.05e-056513143b3630253f5713c4a688c74c4ea0f98c1fe42594
ToppCelldroplet-Fat-Gat-18m-Mesenchymal-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAND2 LONRF1 AOX1 MTOR PAM

4.46e-0513213154152529611eeacf0c547e2a134d5b98c45426b13
DiseaseSkin Abnormalities

ERCC2 ZNF469 SUPV3L1

2.11e-05131263C0037268
DiseaseNeoplasm of uncertain or unknown behavior of bladder

ERCC2 MTOR FGFR3

3.33e-05151263C0496930
DiseaseBenign neoplasm of bladder

ERCC2 MTOR FGFR3

3.33e-05151263C0154017
DiseaseCarcinoma in situ of bladder

ERCC2 MTOR FGFR3

3.33e-05151263C0154091
Diseaseautosomal recessive polycystic kidney disease (implicated_via_orthology)

DZIP1L MTOR NEK8

4.09e-05161263DOID:0110861 (implicated_via_orthology)
DiseaseCarcinoma of bladder

ERCC2 MTOR FGFR3

5.92e-05181263C0699885
Diseaseoral mucosa leukoplakia (is_implicated_in)

NAT2 ERCC2

2.68e-0461262DOID:9655 (is_implicated_in)
DiseaseBladder Neoplasm

NAT2 ERCC2 LAMA2 MTOR FGFR3

3.45e-041401265C0005695
DiseaseMalignant neoplasm of urinary bladder

NAT2 ERCC2 LAMA2 MTOR FGFR3

3.56e-041411265C0005684
Diseaseleft ventricular systolic function measurement

FLNC OBSCN PXDN

8.86e-04441263EFO_0008206
Diseasesenile cataract (is_implicated_in)

NAT2 ERCC2

9.70e-04111262DOID:9669 (is_implicated_in)
DiseaseN-acetylputrescine measurement

NAT2 HDAC10

1.16e-03121262EFO_0800127
Diseasecholesteryl esters to total lipids in large HDL percentage

NAT2 INHBC CYP26C1

2.08e-03591263EFO_0022248
Disease4-acetamidobutanoate measurement

NAT2 HDAC10

2.09e-03161262EFO_0021003
Diseaseneck circumference

ANKRD52 PPM1N

2.95e-03191262EFO_0011043
Diseasereasoning

MAP3K9 ANKRD52

2.95e-03191262EFO_0004350
Diseaseschizophrenia (implicated_via_orthology)

DISC1 NR4A2 MTOR

3.11e-03681263DOID:5419 (implicated_via_orthology)
Diseaseiron biomarker measurement, transferrin measurement

NAT2 TMPRSS6

3.27e-03201262EFO_0004461, EFO_0006341
Diseaseepilepsy (biomarker_via_orthology)

CAPN1 NR4A2

3.60e-03211262DOID:1826 (biomarker_via_orthology)
Diseasetransitional cell carcinoma (is_implicated_in)

NAT2 FGFR3

3.95e-03221262DOID:2671 (is_implicated_in)
Diseaseurinary bladder cancer (is_implicated_in)

NAT2 ERCC2 FGFR3

4.26e-03761263DOID:11054 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
SASVHGVDQRGRLLR

BEST4

111

Q8NFU0
ALVVCGGQGHRRVHR

ARHGEF10

1331

O15013
VQRLEANHGLLVARG

CAVIN3

106

Q969G5
NCLRQRRGFHHELVG

B4GALNT1

411

Q00973
RVVQCVDHRRGGARV

CLK2

176

P49760
VALGAHLRDARRGQR

GTPBP3

231

Q969Y2
VGGRAALHEACARAQ

ASB16

141

Q96NS5
GGAILRHARRQAENI

BRPF3

686

Q9ULD4
REGAEHERGNAILVR

PAM

441

P19021
NGRIRGIHRLGAAVA

DMAC2

16

Q9NW81
AGAALLLVHVRRRGH

DLL3

506

Q9NYJ7
LLVHVRRRGHSQDAG

DLL3

511

Q9NYJ7
AADLRGRTALHRGAV

ANKRD52

716

Q8NB46
RTGLHLAAARGNVDI

ANKRD46

46

Q86W74
QRARELGLGRHENAI

CAPN1

21

P07384
GHLAAQVQAALRRGA

DISC1

406

Q9NRI5
NFHLVRSAVRDLGGI

ASPM

1216

Q8IZT6
DIKARALQVRGARGH

ASXL1

616

Q8IXJ9
NKHGRAVRCVLERGE

AOX1

826

Q06278
AHVVRTGIGRARAEL

POLL

46

Q9UGP5
DRLLLHGNRLQGVHR

RTN4RL2

206

Q86UN3
QGVHRAAFRGLSRLT

RTN4RL2

216

Q86UN3
RHARAAVLGENGRVL

RALY

66

Q9UKM9
REGGAALANALRRHL

PTPRN2

141

Q92932
AHGREQRRRAVGLAA

P2RY8

226

Q86VZ1
RRNHAVLERRGSGAF

ANKRD34B

421

A5PLL1
LRGHIQRRHAGVAEG

DZIP1L

181

Q8IYY4
IAGELHRLRGHVAVR

ABCC10

646

Q5T3U5
HRLRGHVAVRGLSKG

ABCC10

651

Q5T3U5
FVLAHGGRRVAILRD

PAPSS2

316

O95340
VACRTLGARHAGLRG

ESPNL

761

Q6ZVH7
LGARHAGLRGQEAAR

ESPNL

766

Q6ZVH7
VAARVRVGGKHQIHR

INHBC

221

P55103
RVGGKHQIHRRGIDC

INHBC

226

P55103
HQIHRRGIDCQGGSR

INHBC

231

P55103
RARAAGRLGELLHQG

LONRF1

211

Q17RB8
LVAGSRQFCHGAERR

FER1L4

581

A9Z1Z3
RHRREVVGRSAIFGG

PCYOX1L

101

Q8NBM8
ARHVIINVGGCRVRL

KCNG2

16

Q9UJ96
IHAAGGTIRRRRVEG

PPM1N

211

Q8N819
VQLNGARGVIDARVH

FLNC

2431

Q14315
VRVTRNLRQHAGIGH

NRXN2

376

Q9P2S2
RIRVVGRGAFGIVHL

NEK8

6

Q86SG6
AMRHAAQCVGRAIRG

ERCC2

656

P18074
RHRRVNGTIFGGICE

LAMA2

741

P24043
NIGVEQIRVVHRDGR

MED17

496

Q9NVC6
QHAVQAALGARGLRV

HSPA12B

496

Q96MM6
RGRARLLVGNDDVHI

HUWE1

2601

Q7Z6Z7
RVVAAGAQRVRGIHS

NDUFA10

16

O95299
RRNEDIQVGGLIRGH

MEI1

871

Q5TIA1
RRAGGRLHLNEAVSF

PTK6

131

Q13882
HLQGVGDLRGRVARC

FAM81B

206

Q96LP2
ARGRQDRGDIRHIQA

KIF19

391

Q2TAC6
RHRLVLHNVGFADRG

OBSCN

2041

Q5VST9
RGARLTAARLGRAQH

CCDC105

131

Q8IYK2
TAARLGRAQHQINGR

CCDC105

136

Q8IYK2
AAGAIRGRAARVAHI

CTNNA3

536

Q9UI47
RNGHIATRAQAIAIG

PIKFYVE

396

Q9Y2I7
LDVAVRRGLSHGAQR

HDAC10

491

Q969S8
RRVRLNVGGLAHEVL

KCNB1

31

Q14721
AAQRFILRHVGELGA

KLHL21

156

Q9UJP4
QRGGRTGALHLRRVE

CASC3

51

O15234
SGGLARRRVAAEHAQ

DOCK8-AS1

156

Q5T8R8
GAIRGRAARVIHIIN

CTNNA2

541

P26232
TAGAIRGRAARVIHV

CTNNA1

541

P35221
LRHRHEALARAGVLG

DMAP1

391

Q9NPF5
GAHGRARALLERLQS

DDX51

26

Q8N8A6
VRCGLEHERQGRRAG

CCDC9

231

Q9Y3X0
GLGERVAAHVQRARA

BFSP1

46

Q12934
DVRGSHGRQVCRRHE

BMP8A

291

Q7Z5Y6
GIRARDQLHRHLEGA

CYP26C1

236

Q6V0L0
CIIRGDLANVRVGRH

DCTN5

46

Q9BTE1
GLEAIFDHIVRRNRG

NAT2

51

P11245
GPRRVNHAAVAVGHR

KLHDC3

11

Q9BQ90
GIRDNERSGRARVHV

GSN

246

P06396
AGVFRGGHDILVRSR

COPG1

831

Q9Y678
RIERTGIAAIAVHGR

DUS2

171

Q9NX74
RGEHRIGGIKLRHQQ

FGFR3

196

P22607
VLSRNHGLGRRQLVG

FAM237A

106

A0A1B0GTK4
RQAGHRLGAHLDRLV

CAND2

246

O75155
DGNRALQRHVIARGH

DIRAS3

96

O95661
RQIVTAGLGDHLARR

DHX37

926

Q8IY37
IGQARAEGRAVLVHC

DUSP12

101

Q9UNI6
AAGGALQVVHSRQLR

SLC38A10

1096

Q9HBR0
IRHANVIDLRIGGSA

CFAP47

1036

Q6ZTR5
HQVQRRGAGAARLEH

CEP131

281

Q9UPN4
RGGAHHRRCEVALLG

MAP3K9

741

P80192
HGSNVAAVRRVLDRG

NEURL4

1421

Q96JN8
RLEGLVHSQGARLAA

PTX4

156

Q96A99
VHSQGARLAALEGRL

PTX4

161

Q96A99
AHVSRIVGELVRAGR

ITPRIPL2

121

Q3MIP1
LGADRNEGRRHAAVL

MTOR

156

P42345
NGVVLHRLQCVRGFG

NR4A2

466

P43354
AAVRGLRHGQLVVFG

FREM3

471

P0C091
ILRRVGEARTQHGGS

MRPS23

131

Q9Y3D9
QQLHGESLLARARRG

THAP8

206

Q8NA92
GRHGARVGRLVSAIV

LTB4R2

216

Q9NPC1
RRHGRATFCALGRGI

FAM120AOS

76

Q5T036
VDVLQRRVDGRGRLH

PRELID3A

36

Q96N28
RTVAGVILENHLRGR

SBNO2

286

Q9Y2G9
IGESQAGGQHRTRLR

SBNO2

356

Q9Y2G9
RLPAGRQAGHRAAIC

SUPV3L1

11

Q8IYB8
RHERLIRLHAVCSGG

SRMS

281

Q9H3Y6
GLLDVGNIQHRAARA

SSBP3-AS1

31

Q7Z2R9
GNIQHRAARARGLTR

SSBP3-AS1

36

Q7Z2R9
ARHGGRFALLRIVNV

B4GALNT4

731

Q76KP1
QRGDRFHRVLLAHGV

CHST7

306

Q9NS84
RLRHRVVGAVIDQGL

C11orf98

31

E9PRG8
RVARERLGHHLQGLR

VPS51

401

Q9UID3
QRLGGHFCDVTVRIR

ZBTB45

26

Q96K62
SALRVGLARHVGQAV

TRPM5

106

Q9NZQ8
GHVVFDARQRRLAVG

SPEM3

1151

A0A1B0GUW6
VRLGAQVHVRDHSGR

SOWAHA

406

Q2M3V2
EAERRHRVRLAVGNG

SLC27A1

351

Q6PCB7
GHLRLVNGAHRCEGR

SSC4D

471

Q8WTU2
GCQGVSEAAHRLARR

PSD2

306

Q9BQI7
VAEERAGRHCGALRV

RPL15

101

P61313
QAVLLRQRHGSGTGR

VSTM2B

246

A6NLU5
FGLCGDVHVRLRQRI

TMC4

301

Q7Z404
CGRAFRQRGNLRGHL

ZNF408

501

Q9H9D4
SHRGLLRQGIVQRSG

PXDN

931

Q92626
QAAIRGLVAEGHRLA

VCL

516

P18206
VGARLLERFHGASRV

WNT6

246

Q9Y6F9
GEAVAAAGRLQRFLH

SPTBN4

1081

Q9H254
RGAQEVGERLQQRHG

PLEC

1291

Q15149
LAVGAVAVGVARARH

PIGR

651

P01833
QAFRGHQGRGIRAIA

WDR6

291

Q9NNW5
HQGRGIRAIAAHERQ

WDR6

296

Q9NNW5
GAQVRLDTRGCIAHR

NEURL3

26

Q96EH8
EAGVAILGRARGAHR

PRSS55

26

Q6UWB4
ALARHLQRVAEAGGQ

ZNF862

806

O60290
GSRELLRGHLQERHA

ZNF469

3126

Q96JG9
QIRRHERQLHGAGRS

ZNF853

611

P0CG23
EVLGRQHRAALAGRS

VWA5B2

741

Q8N398
LGARGLVHRDLATRN

TNK1

236

Q13470
GVCRELARHQRIHTG

ZNF529

376

Q6P280
AGRLDTRGELQAARH

THAP10

106

Q9P2Z0
LHQRIHRVRGGCVSP

ZNF777

591

Q9ULD5
ELIGQDAAGRRLHRA

VWA7

701

Q9Y334
RGLVGAAHTRQELAA

TULP3

291

O75386
GLVLAALARRGRRGH

AVPR2

56

P30518
VRGRHICGGALIADR

TMPRSS6

596

Q8IU80
VAEGRTRGRAIIHFA

XKR8

276

Q9H6D3
RGDERQGVQHLLRAV

MYO1F

646

O00160